3MKA

crystal structure of mycobacterium tuberculosis proteasome with propetide and an t1a mutation at beta-subunit

• Total interactions analyzed: 378
• Total true interactions: 92
• Strongest Interaction:
  • Chains: G-2
  • Int. Res.: 53
  • Norm. En. per Res.: -4.6442
• Hub Node: D(8)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-40.7463	-32.0514	-237.779	-310.5767	101	32	8	11602	2	26	27
A-H	-54.5463	-91.065	-200.059	-345.6703	76	8	4	8146	12	46	39
A-I	0.0	0.0	-7.968	-7.968	8	0	0	424	0	0	0
A-O	-26.4812	-63.0442	-118.796	-208.3213	86	19	1	6525	6	24	23
A-P	-20.1205	-50.051	-136.743	-206.9145	55	6	3	5558	3	20	25
A-S	0.0	0.0	-0.1253	-0.1253	4	0	0	39	0	0	0
A-1	0.0	0.0	-0.7264	-0.7264	2	0	0	70	0	0	0
B-C	-54.217	-58.0637	-189.734	-302.0147	74	14	4	7874	12	43	39
B-H	-16.759	-50.0802	-139.833	-206.6722	55	8	3	5600	3	21	25
B-I	-28.4375	-17.7286	-146.638	-192.8041	87	8	3	6946	2	24	26
B-O	0.0	0.0	-4.7179	-4.7179	14	6	0	673	0	0	0
B-S	0.0	0.0	-3.5253	-3.5253	10	0	0	199	0	0	0
B-1	0.0	0.0	-0.4673	-0.4673	3	0	0	54	0	0	0
C-E	-58.1579	-129.7875	-150.697	-338.6423	82	9	2	6148	10	26	18
C-H	-5.7332	-44.4327	-92.4207	-142.5867	91	19	8	5929	4	25	16
C-I	-10.781	-49.5002	-159.417	-219.6982	58	8	3	6066	2	23	27
C-J	-3.6715	-38.2214	-69.4993	-111.3922	93	18	6	6296	3	25	17
C-R	-56.32	-112.3565	-95.9937	-264.6702	58	10	1	4625	12	28	25
D-E	-38.1749	-22.3692	-184.126	-244.6701	72	7	5	7884	12	43	38
D-F	0.0	0.0	58.9404	58.9404	4	12	0	230	0	0	0
D-K	-29.9636	-25.7583	-136.247	-191.9688	86	21	3	6871	3	24	26
D-M	0.0	0.0	-38.8684	-38.8684	27	12	3	2382	0	0	0
D-Q	-53.307	-18.1011	-227.846	-299.2541	97	30	8	10516	2	24	26
D-R	-15.521	-17.4058	-126.042	-158.9688	52	5	3	5198	2	17	20
D-W	0.0	0.0	-3.5051	-3.5051	10	0	1	266	0	0	0
D-Y	0.0	0.0	-26.7428	-26.7428	20	1	1	1456	0	0	0
E-H	-47.3554	-106.0044	-96.2016	-249.5614	56	6	1	4413	12	28	24
E-K	-8.8018	-43.8459	-141.434	-194.0818	56	5	3	5408	2	20	24
E-L	0.0	-4.5807	-104.775	-109.3556	87	5	7	5563	2	25	17
E-R	-18.1988	-51.1857	-96.2224	-165.6069	80	16	7	5671	5	25	16
F-G	-52.8546	-52.9702	-196.482	-302.3068	73	9	4	7878	12	43	39
F-K	0.0	0.0	-11.5639	-11.5639	8	0	0	533	0	0	0
F-M	-20.2958	-13.0569	-130.478	-163.8307	84	10	3	6439	2	24	27
F-N	-11.9499	-42.8351	-139.764	-194.549	56	8	3	5589	3	20	24
F-Q	0.0	0.0	-3.1672	-3.1672	2	0	0	137	0	0	0
F-W	-21.2477	1.9415	-226.459	-245.7652	100	21	7	10209	2	23	27
F-Y	0.0	0.0	-0.4224	-0.4224	7	0	0	91	0	0	0
G-N	-4.3176	-43.5141	-107.455	-155.2867	85	4	6	5588	3	23	17
G-V	-74.0965	-95.7477	-163.475	-333.3191	83	15	2	6502	11	26	18
G-W	-12.6368	-46.846	-143.487	-202.9699	55	10	3	5624	2	21	25
G-X	-8.941	-52.2543	-114.884	-176.0792	89	13	7	6413	6	25	16
G-2	-44.5519	-110.6756	-90.9131	-246.1406	53	7	1	4406	11	28	23
H-L	-75.3517	-96.3644	-161.701	-333.4171	80	7	2	6367	13	26	19
H-P	-6.1096	-16.221	-102.29	-124.6206	86	17	6	5651	2	26	18
I-J	-45.2979	-47.482	-187.634	-280.4139	73	12	4	8010	13	45	39
I-S	-38.5306	-10.266	-203.312	-252.1087	93	13	5	8981	2	24	25
I-U	0.0	0.0	-8.1152	-8.1152	5	0	0	238	0	0	0
I-1	0.0	0.0	-2.4331	-2.4331	6	0	0	125	0	0	0
J-R	-55.0049	-27.5262	-140.332	-222.8631	76	9	2	5843	11	26	16
J-S	-8.9767	-49.0139	-146.46	-204.4506	55	7	3	5716	2	20	24
J-T	-41.1874	-89.8638	-96.2053	-227.2565	93	17	6	6325	7	24	16
J-Z	-48.23	-107.7682	-95.0162	-251.0144	55	5	1	4428	11	28	26
K-L	-59.7881	-47.1861	-185.837	-292.8112	73	14	4	7826	12	44	38
K-M	-37.3243	-4.5473	-233.534	-275.4056	97	28	8	10483	3	23	28
K-Q	0.0	0.0	-25.7354	-25.7354	11	5	1	1009	0	0	0
K-W	0.0	0.0	12.947	12.947	15	21	1	1057	0	0	0
L-M	-11.2753	-25.0943	-143.582	-179.9516	56	10	3	5726	2	21	26
L-N	-14.6434	-57.4109	-106.136	-178.1903	90	12	6	5810	7	24	17
L-P	-47.1026	-106.8593	-97.0607	-251.0225	57	8	1	4502	11	28	25
M-N	-62.6046	-48.5329	-215.009	-326.1464	76	15	4	8276	13	45	40
M-Q	0.0	0.0	-26.7202	-26.7202	18	0	1	1000	0	0	0
M-W	0.0	0.0	-34.0188	-34.0188	25	19	2	2525	0	0	0
M-Y	0.0	0.0	-0.0036	-0.0036	2	0	0	3	0	0	0
N-P	-77.1977	-101.3173	-158.856	-337.371	82	11	2	6270	12	26	18
N-V	-47.8989	-108.5185	-96.8039	-253.2213	56	6	1	4451	12	28	24
O-P	-52.5276	-53.1476	-183.126	-288.8013	73	10	4	7664	13	42	39
O-U	-12.6152	12.8108	-149.413	-149.2175	88	13	4	7276	2	24	27
O-V	-14.0037	-49.0595	-138.078	-201.1412	56	7	3	5414	2	20	26
O-1	0.0	0.0	-10.1979	-10.1979	7	0	0	518	0	0	0
P-V	-27.5809	-68.5928	-114.494	-210.6677	87	9	8	6619	9	25	16
Q-R	-45.1891	-21.0737	-172.322	-238.5848	71	6	4	7693	12	43	36
Q-Y	-18.6384	-13.9231	-164.105	-196.6665	90	16	3	7382	3	25	29
Q-Z	-23.0449	-48.4355	-138.808	-210.2884	52	6	3	5548	2	20	23
R-Z	-29.5291	-58.0737	-90.6991	-178.3019	80	18	3	5046	5	25	16
S-T	-50.0759	-22.1201	-187.657	-259.8529	74	4	4	7811	13	42	38
S-U	0.0	0.0	-18.7545	-18.7545	17	5	2	968	0	0	0
S-1	-5.3607	-1.2962	-126.035	-132.6919	81	12	3	6191	3	23	25
T-X	-37.2017	-105.1043	-88.7628	-231.0688	52	5	1	4238	11	28	24
T-Z	-72.0585	-47.9035	-159.945	-279.907	77	7	2	6188	11	26	17
T-1	-15.6476	-52.1809	-147.253	-215.0815	55	7	3	5678	3	20	25
T-2	-9.9539	-64.6517	-96.4898	-171.0954	86	12	7	5532	5	25	17
U-V	-47.6731	-49.3672	-194.003	-291.0433	73	6	4	7827	13	43	38
U-1	-30.5639	2.3947	-213.02	-241.1893	96	26	11	10092	2	24	27
U-2	-16.7488	-56.1501	-146.062	-218.9609	57	10	3	5623	3	20	27
V-2	-5.5901	-47.6037	-100.04	-153.2338	83	9	5	5263	4	23	16
W-X	-45.5569	-70.0588	-178.501	-294.1167	72	10	4	7500	11	44	36
W-Y	-9.3655	-24.8017	-101.77	-135.9372	76	7	3	5550	2	24	23
X-Y	-12.8856	-47.8355	-139.389	-200.11	56	9	3	5430	2	18	22
X-Z	-3.4463	-60.7904	-81.8022	-146.0389	80	7	2	4794	5	22	16
X-2	-74.3537	-98.4542	-158.809	-331.6169	78	7	2	6191	12	27	17
Y-Z	-46.019	-59.4575	-189.177	-294.6536	74	5	4	7680	12	43	37
1-2	-43.9055	-61.8505	-190.259	-296.015	73	7	4	7760	12	43	37

Interface residues

• A-B: ALA100B, ALA104B, ALA115A, ALA12A, ALA12B, ALA148B, ALA20A, ARG135B, ARG140B, ARG14A, ARG14B, ARG16A, ARG16B, ARG21A, ARG224A, ARG26A, ARG48A, ARG75A, ARG76A, ARG85B, ARG97B, ASN101B, ASN69A, ASN73A, ASP144B, ASP149B, ASP72A, GLN105B, GLN114A, GLN114B, GLN11A, GLN11B, GLN51A, GLN98B, GLU10A, GLU10B, GLU113A, GLU113B, GLU119A, GLU126B, GLU137B, GLU150B, GLU15A, GLU15B, GLU18A, GLU70A, GLY108B, GLY145B, GLY77A, GLY96B, ILE110A, ILE141B, ILE147B, ILE7A, ILE7B, LEU107B, LEU138B, LEU19A, LEU50A, LEU74A, LYS116A, LYS134B, LYS22A, LYS28A, LYS67A, MET13A, MET13B, PHE111A, PHE111B, PHE68A, PHE6A, PHE6B, PHE71A, PHE81B, PRO117A, PRO136B, PRO151B, PRO46A, PRO4A, PRO9A, PRO9B, SER146B, SER17A, SER47A, SER49A, SER54A, SER8A, SER8B, THR106B, THR109B, THR112A, THR112B, THR142B, THR95B, TYR103B, TYR118A, TYR139B, TYR143B, TYR5A, TYR5B, VAL102B
• A-H: ALA-25H, ALA356H, ALA360H, ALA82A, ALA88A, ARG-27H, ARG217A, ARG219A, ARG220A, ARG224A, ARG357H, ARG75A, ARG76A, ARG85A, ARG91A, ARG92A, ASN73A, ASP-31H, ASP-37H, ASP338H, ASP339H, ASP58A, ASP72A, ASP83A, ASP90A, GLN-26H, GLN51A, GLN80A, GLU-23H, GLU354H, GLU362H, GLU364H, GLU367H, GLU370H, GLU55A, GLY371H, GLY77A, GLY78A, GLY86A, HIS365H, ILE336H, ILE79A, LEU-21H, LEU-22H, LEU-29H, LEU-36H, LEU358H, LEU363H, LEU369H, LEU56A, LYS368H, MET386H, PHE-30H, PHE-33H, PHE222A, PHE355H, PHE81A, PRO-20H, PRO373H, SER-34H, SER-35H, SER49A, SER54A, THR-32H, THR337H, THR84A, TYR359H, TYR366H, TYR57A, TYR87A, TYR89A, VAL353H, VAL361H, VAL372H, VAL60A, VAL94A
• A-I: GLU10I, ILE7I, PHE6A, PHE6I, PRO4A, PRO9I, SER8I, TYR5A
• A-O: ALA100A, ALA104A, ALA115O, ALA12A, ALA12O, ALA148A, ALA20O, ARG135A, ARG14A, ARG14O, ARG16A, ARG16O, ARG21O, ARG26O, ARG48O, ARG75O, ARG76O, ARG85A, ARG97A, ASN101A, ASN69O, ASN73O, ASP144A, ASP149A, ASP72O, GLN105A, GLN114A, GLN114O, GLN11A, GLN11O, GLN51O, GLN98A, GLU10A, GLU113A, GLU113O, GLU119O, GLU126A, GLU137A, GLU150A, GLU15O, GLU18O, GLU70O, GLY108A, GLY145A, GLY77O, ILE110O, ILE141A, ILE147A, ILE7A, ILE7O, LEU107A, LEU138A, LEU19O, LEU50O, LEU74O, LYS116O, LYS134A, LYS22O, LYS67O, MET13A, MET13O, PHE111A, PHE68O, PHE6A, PHE71O, PHE81A, PRO117O, PRO136A, PRO151A, PRO46O, PRO9A, SER146A, SER17O, SER47O, SER49O, SER54O, SER8A, THR106A, THR109A, THR112A, THR142A, TYR103A, TYR118O, TYR139A, TYR143A, VAL102A
• A-P: ALA-39P, ALA377P, ALA82A, ALA88A, ARG382P, ARG388P, ARG85A, ARG91A, ARG92A, ARG97A, ASN101A, ASN381P, ASP-31P, ASP-37P, ASP83A, ASP90A, ASP93A, GLN105A, GLN80A, GLN98A, GLU132A, GLU362P, GLU370P, GLY371P, GLY378P, GLY77A, GLY86A, HIS129A, HIS365P, HIS410P, ILE380P, ILE385P, LEU-36P, LEU363P, LEU369P, LEU374P, LEU383P, LYS379P, PHE-33P, PHE376P, PHE81A, PRO373P, SER-34P, SER-35P, THR-32P, THR375P, THR84A, THR95A, TYR366P, TYR87A, TYR89A, VAL-38P, VAL102A, VAL372P, VAL94A
• A-S: ILE7S, PHE6A, PHE6S, PRO4A
• A-1: PHE61, PHE6A
• B-C: ALA-25C, ALA356C, ALA360C, ALA82B, ALA88B, ARG-27C, ARG219B, ARG220B, ARG224B, ARG357C, ARG75B, ARG76B, ARG85B, ARG91B, ARG92B, ASN73B, ASP-31C, ASP-37C, ASP338C, ASP339C, ASP58B, ASP72B, ASP83B, ASP90B, ASP93B, GLN-26C, GLN51B, GLN80B, GLU-23C, GLU354C, GLU362C, GLU364C, GLU367C, GLU370C, GLU55B, GLY371C, GLY77B, GLY78B, GLY86B, HIS365C, ILE336C, ILE79B, LEU-21C, LEU-22C, LEU-29C, LEU-36C, LEU358C, LEU363C, LEU369C, LEU56B, LYS368C, MET386C, PHE-30C, PHE-33C, PHE222B, PHE355C, PHE81B, PRO-20C, PRO373C, SER-34C, SER-35C, SER54B, THR-32C, THR337C, THR84B, TYR359C, TYR366C, TYR57B, TYR87B, TYR89B, VAL353C, VAL361C, VAL60B, VAL94B
• B-H: ALA-39H, ALA377H, ALA82B, ALA88B, ARG382H, ARG388H, ARG85B, ARG91B, ARG92B, ARG97B, ASN101B, ASN381H, ASP-31H, ASP-37H, ASP83B, ASP90B, ASP93B, GLN80B, GLN98B, GLU132B, GLU362H, GLU370H, GLY371H, GLY378H, GLY77B, GLY86B, HIS129B, HIS365H, HIS410H, ILE380H, ILE385H, LEU-36H, LEU363H, LEU369H, LEU374H, LEU383H, LYS368H, LYS379H, PHE-33H, PHE376H, PHE81B, PRO373H, SER-34H, SER-35H, THR-32H, THR375H, THR84B, THR95B, TYR366H, TYR87B, TYR89B, VAL-38H, VAL102B, VAL372H, VAL94B
• B-I: ALA100I, ALA104I, ALA115B, ALA12B, ALA12I, ALA148I, ALA20B, ARG135I, ARG140I, ARG14B, ARG14I, ARG16B, ARG16I, ARG224B, ARG26B, ARG48B, ARG75B, ARG76B, ARG85I, ARG97I, ASN101I, ASN45B, ASN69B, ASN73B, ASP144I, ASP149I, ASP72B, GLN105I, GLN114B, GLN114I, GLN11B, GLN11I, GLN51B, GLN98I, GLU10I, GLU113B, GLU113I, GLU119B, GLU137I, GLU150I, GLU15B, GLU18B, GLU70B, GLY108I, GLY145I, GLY77B, HIS152I, ILE110B, ILE141I, ILE147I, ILE7B, ILE7I, LEU107I, LEU138I, LEU19B, LEU50B, LEU74B, LYS116B, LYS22B, LYS67B, MET13B, MET13I, PHE111I, PHE68B, PHE6I, PHE71B, PHE81I, PRO117B, PRO136I, PRO151I, PRO46B, PRO9I, SER146I, SER17B, SER47B, SER49B, SER54B, SER8I, THR106I, THR109I, THR112I, THR142I, TYR103I, TYR118B, TYR139I, TYR143I, VAL102I
• B-O: ALA115O, ALA12O, ARG14O, ARG16O, GLN114O, GLN11O, GLU15O, ILE7O, LEU19O, LYS116O, PHE6B, PRO117O, SER8O, TYR5B
• B-S: ALA115B, ALA12B, ARG16B, GLN114B, GLU15B, ILE7B, LEU19B, LYS116B, PHE6S, PRO117B
• B-1: PHE61, TYR51, TYR5B
• C-E: ALA301C, ALA301E, ALA474C, ALA474E, ALA475C, ALA475E, ALA480C, ALA480E, ARG319C, ARG319E, ARG329C, ARG329E, ARG488C, ARG488E, ARG515C, ARG521C, ARG521E, ASN324C, ASN324E, ASP473C, ASP473E, ASP476C, ASP476E, ASP477C, ASP477E, ASP478C, ASP478E, ASP485C, ASP485E, GLN-5C, GLN322C, GLN322E, GLU519C, GLU519E, GLY-1C, GLY-1E, GLY323C, GLY323E, GLY442C, GLY442E, GLY482C, GLY489C, GLY489E, GLY523E, HIS-2C, HIS-2E, ILE326C, ILE326E, ILE517C, ILE517E, ILE518C, ILE518E, LEU444C, LEU444E, LEU486C, LEU486E, MET325C, MET325E, PHE445C, PHE445E, PRO484C, PRO484E, SER320C, SER320E, SER327C, SER327E, SER441C, SER441E, SER479C, SER479E, SER520C, SER520E, SER522C, SER522E, THR321C, THR321E, THR481C, THR481E, TYR472C, TYR472E, VAL487C, VAL487E
• C-H: ALA-19C, ALA-25C, ALA-39H, ALA349C, ALA350C, ALA352C, ALA377H, ALA384H, ALA392H, ALA393C, ALA393H, ALA394H, ALA425H, ALA426H, ARG-27C, ARG-28H, ARG318C, ARG329C, ARG332C, ARG357C, ARG382H, ARG388H, ARG488C, ASN381H, ASN430H, ASP-31H, ASP-37H, ASP330C, ASP424H, GLN-26C, GLN-5C, GLN322C, GLN396C, GLN437H, GLU-23C, GLU354C, GLU432H, GLU433H, GLU434H, GLY328C, GLY378H, GLY389H, GLY397C, GLY427H, GLY428H, HIS-2C, ILE-17C, ILE326C, ILE380H, ILE385H, ILE431H, ILE490C, LEU-21C, LEU-21H, LEU-22C, LEU-29C, LEU-36H, LEU-4C, LEU358C, LEU391H, LEU398C, LEU401H, LEU444H, LYS447H, LYS451H, MET325C, MET386H, MET395H, PHE-30C, PHE-33C, PHE355C, PHE423H, PRO-20C, PRO-24C, PRO-3C, SER-18C, SER-34H, SER320C, SER327C, SER422H, THR-32H, THR348C, TRP429H, TYR335C, TYR436H, VAL-38H, VAL331C, VAL351C, VAL353C, VAL387H, VAL487C
• C-I: ALA-39C, ALA377C, ALA411C, ALA82I, ALA88I, ARG382C, ARG388C, ARG85I, ARG91I, ARG92I, ARG97I, ASN101I, ASN381C, ASP-31C, ASP-37C, ASP83I, ASP90I, ASP93I, GLN105I, GLN80I, GLN98I, GLU132I, GLU362C, GLU370C, GLY371C, GLY378C, GLY77I, GLY86I, HIS129I, HIS365C, HIS410C, ILE380C, ILE385C, LEU-36C, LEU363C, LEU369C, LEU374C, LEU383C, LYS368C, LYS379C, PHE-33C, PHE376C, PHE81I, PRO373C, SER-34C, SER-35C, THR-32C, THR375C, THR84I, THR95I, TYR359C, TYR366C, TYR87I, TYR89I, VAL-38C, VAL102I, VAL372C, VAL94I
• C-J: ALA-19J, ALA-25J, ALA-39C, ALA349J, ALA350J, ALA377C, ALA384C, ALA392C, ALA393C, ALA393J, ALA394C, ALA425C, ALA426C, ARG-27C, ARG-27J, ARG-28C, ARG318J, ARG329J, ARG332J, ARG357J, ARG382C, ARG388C, ARG488J, ASN381C, ASN390C, ASN430C, ASP-31C, ASP-37C, ASP330J, ASP424C, GLN-26J, GLN-5J, GLN322J, GLN396C, GLN396J, GLN437C, GLU-23J, GLU354J, GLU432C, GLU433C, GLU434C, GLY-15J, GLY328J, GLY378C, GLY389C, GLY397J, GLY427C, GLY428C, HIS-2J, ILE-17J, ILE326J, ILE385C, ILE431C, ILE490J, LEU-21C, LEU-21J, LEU-22J, LEU-29J, LEU-36C, LEU-4J, LEU358J, LEU391C, LEU398J, LEU401C, LEU444C, LYS447C, LYS451C, MET325J, MET395C, PHE-30C, PHE-30J, PHE-33J, PHE355J, PHE423C, PRO-20J, PRO-24J, PRO-3J, SER-16J, SER-18J, SER-34C, SER320J, SER327J, SER422C, THR-32C, THR348J, TRP429C, TYR335J, TYR436C, VAL-38C, VAL331J, VAL351J, VAL353J, VAL387C
• C-R: ALA446C, ALA446R, ALA470C, ALA470R, ALA474C, ALA474R, ALA475C, ALA475R, ARG465C, ARG465R, ARG521C, ARG521R, ASP473C, ASP473R, ASP476C, ASP476R, ASP477C, ASP477R, ASP478C, ASP478R, GLN456C, GLN456R, GLU434R, GLU469C, GLU469R, GLY442C, GLY442R, ILE517C, ILE517R, LEU444C, LEU444R, LEU453C, LEU453R, LYS447C, LYS447R, LYS451C, LYS451R, LYS452C, LYS452R, MET450C, MET450R, PHE445C, PHE445R, SER441C, SER441R, SER443C, SER443R, SER448C, SER448R, SER449C, SER449R, TYR436C, TYR454C, TYR454R, TYR472C, TYR472R, VAL466C, VAL466R
• D-E: ALA-25E, ALA356E, ALA360E, ALA82D, ALA88D, ARG-27E, ARG219D, ARG220D, ARG224D, ARG357E, ARG75D, ARG76D, ARG85D, ARG91D, ARG92D, ASP-31E, ASP-37E, ASP338E, ASP339E, ASP58D, ASP72D, ASP83D, ASP90D, GLN-26E, GLN51D, GLN80D, GLU-23E, GLU354E, GLU362E, GLU364E, GLU367E, GLU370E, GLU55D, GLY371E, GLY77D, GLY78D, GLY86D, HIS365E, ILE79D, LEU-21E, LEU-22E, LEU-29E, LEU-36E, LEU358E, LEU363E, LEU369E, LEU56D, LYS368E, MET386E, PHE-30E, PHE-33E, PHE222D, PHE355E, PHE81D, PRO-20E, PRO-24E, PRO373E, SER-34E, SER-35E, SER54D, THR-32E, THR337E, THR84D, TYR359E, TYR366E, TYR57D, TYR87D, TYR89D, VAL353E, VAL361E, VAL60D, VAL94D
• D-F: PHE3D, PHE6F, TYR5D, TYR5F
• D-K: ALA100K, ALA104K, ALA115D, ALA12D, ALA12K, ALA148K, ALA20D, ARG135K, ARG140K, ARG14D, ARG14K, ARG16D, ARG16K, ARG224D, ARG26D, ARG48D, ARG75D, ARG76D, ARG85K, ARG97K, ASN101K, ASN69D, ASN73D, ASP144K, ASP149K, ASP72D, GLN105K, GLN114D, GLN114K, GLN11D, GLN11K, GLN51D, GLN98K, GLU10K, GLU113D, GLU113K, GLU119D, GLU137K, GLU150K, GLU15D, GLU18D, GLU70D, GLY108K, GLY145K, GLY23D, GLY77D, ILE110D, ILE141K, ILE147K, ILE7D, ILE7K, LEU107K, LEU138K, LEU19D, LEU50D, LEU74D, LYS116D, LYS22D, LYS67D, MET13D, MET13K, PHE111K, PHE3D, PHE68D, PHE6K, PHE71D, PHE81K, PRO117D, PRO151K, PRO46D, PRO9K, SER146K, SER17D, SER47D, SER49D, SER54D, SER8K, THR106K, THR109K, THR112K, THR142K, TYR103K, TYR118D, TYR139K, TYR143K, VAL102K
• D-M: ALA115D, ALA12D, ARG14D, ARG16D, GLN114D, GLN11D, GLU10D, GLU113D, GLU15D, ILE110D, ILE7D, LEU19D, LYS116D, MET13D, PHE111D, PHE3D, PHE3M, PHE6D, PHE6M, PRO117D, PRO4M, PRO9D, SER17D, SER2M, SER8D, THR112D, TYR5M
• D-Q: ALA100D, ALA104D, ALA115Q, ALA12D, ALA12Q, ALA148D, ALA20Q, ARG135D, ARG140D, ARG14D, ARG14Q, ARG16D, ARG16Q, ARG224Q, ARG26Q, ARG48Q, ARG75Q, ARG76Q, ARG85D, ARG97D, ASN101D, ASN69Q, ASN73Q, ASP144D, ASP149D, ASP72Q, GLN105D, GLN114Q, GLN11D, GLN11Q, GLN51Q, GLN98D, GLU10D, GLU10Q, GLU113D, GLU113Q, GLU119Q, GLU137D, GLU150D, GLU15D, GLU15Q, GLU18Q, GLU70Q, GLY108D, GLY145D, GLY23Q, GLY77Q, ILE110Q, ILE141D, ILE147D, ILE7D, ILE7Q, LEU107D, LEU138D, LEU19Q, LEU50Q, LEU74Q, LYS116Q, LYS134D, LYS22Q, LYS67Q, MET13D, MET13Q, PHE111D, PHE3D, PHE3Q, PHE68Q, PHE6D, PHE6Q, PHE71Q, PHE81D, PRO117Q, PRO136D, PRO151D, PRO46Q, PRO4D, PRO4Q, PRO9D, PRO9Q, SER146D, SER17Q, SER47Q, SER49Q, SER54Q, SER8D, SER8Q, THR106D, THR109D, THR112D, THR142D, TYR103D, TYR118Q, TYR139D, TYR143D, TYR5D, TYR5Q, VAL102D
• D-R: ALA-39R, ALA377R, ALA82D, ALA88D, ARG382R, ARG388R, ARG85D, ARG91D, ARG92D, ARG97D, ASN101D, ASN381R, ASP-31R, ASP-37R, ASP83D, ASP90D, ASP93D, GLN105D, GLN80D, GLN98D, GLU362R, GLU370R, GLY371R, GLY378R, GLY77D, GLY86D, HIS365R, HIS410R, ILE380R, ILE385R, LEU-36R, LEU363R, LEU369R, LEU374R, LYS379R, PHE-33R, PHE376R, PHE81D, PRO373R, SER-34R, SER-35R, THR-32R, THR375R, THR84D, THR95D, TYR366R, TYR87D, TYR89D, VAL-38R, VAL102D, VAL372R, VAL94D
• D-W: ALA115W, ALA12W, ARG16W, GLU15W, ILE7W, LEU19W, LYS116W, PHE3D, PRO4D, TYR5D
• D-Y: ALA115Y, ALA12Y, ARG14Y, ARG16Y, GLN114Y, GLN11Y, GLU10Y, GLU15Y, ILE7Y, LEU19Y, LYS116Y, MET13Y, PHE3D, PHE6D, PHE6Y, PRO117Y, PRO4D, PRO9Y, SER8Y, TYR5D
• E-H: ALA446E, ALA446H, ALA470E, ALA470H, ALA474E, ALA474H, ALA475E, ALA475H, ARG521E, ARG521H, ASP473E, ASP473H, ASP476E, ASP476H, ASP477E, ASP477H, ASP478E, ASP478H, GLN456E, GLN456H, GLU434H, GLU469E, GLU469H, GLY442E, GLY442H, ILE517E, ILE517H, LEU444E, LEU444H, LEU453E, LEU453H, LYS447E, LYS447H, LYS451E, LYS451H, LYS452E, LYS452H, MET450E, MET450H, PHE445E, PHE445H, SER441E, SER441H, SER443E, SER443H, SER448E, SER448H, SER449E, SER449H, TYR436H, TYR454E, TYR454H, TYR472E, TYR472H, VAL466E, VAL466H
• E-K: ALA-39E, ALA377E, ALA411E, ALA82K, ALA88K, ARG382E, ARG388E, ARG85K, ARG91K, ARG92K, ARG97K, ASN101K, ASN381E, ASP-31E, ASP-37E, ASP83K, ASP90K, ASP93K, GLN105K, GLN80K, GLN98K, GLU132K, GLU362E, GLU370E, GLY371E, GLY378E, GLY77K, GLY86K, HIS129K, HIS365E, HIS410E, ILE380E, ILE385E, LEU-36E, LEU363E, LEU369E, LEU374E, LEU383E, LYS379E, PHE-33E, PHE376E, PHE81K, PRO373E, SER-34E, SER-35E, THR-32E, THR375E, THR84K, THR95K, TYR366E, TYR87K, TYR89K, VAL-38E, VAL102K, VAL372E, VAL94K
• E-L: ALA-19L, ALA-25L, ALA-39E, ALA349L, ALA350L, ALA377E, ALA384E, ALA392E, ALA393L, ALA394E, ALA425E, ALA426E, ARG-27E, ARG-27L, ARG-28E, ARG318L, ARG329L, ARG332L, ARG357L, ARG382E, ARG388E, ARG488L, ASN381E, ASN430E, ASP-31E, ASP-37E, ASP330L, ASP424E, GLN-26L, GLN-5L, GLN322L, GLN396E, GLN396L, GLN437E, GLU-23L, GLU354L, GLU432E, GLU433E, GLU434E, GLY328L, GLY378E, GLY389E, GLY397L, GLY427E, GLY428E, HIS-2L, ILE-17L, ILE326L, ILE385E, ILE431E, ILE490L, LEU-21L, LEU-22L, LEU-29L, LEU-36E, LEU-4L, LEU358L, LEU391E, LEU398L, LEU401E, LEU444E, LYS447E, LYS451E, MET325L, MET395E, PHE-30L, PHE-33L, PHE355L, PHE423E, PRO-20L, PRO-24L, PRO-3L, SER-18L, SER-34E, SER320L, SER327L, SER422E, THR-32E, THR348L, TRP429E, TYR335L, TYR436E, VAL-38E, VAL331L, VAL351L, VAL353L, VAL387E
• E-R: ALA-19E, ALA-25E, ALA-39R, ALA349E, ALA350E, ALA377R, ALA384R, ALA392R, ALA393E, ALA425R, ALA426R, ARG-27E, ARG-27R, ARG-28R, ARG318E, ARG329E, ARG332E, ARG357E, ARG382R, ARG388R, ARG488E, ASN381R, ASN390R, ASN430R, ASP-31R, ASP-37R, ASP330E, ASP424R, GLN-26E, GLN322E, GLN396E, GLN437R, GLU-23E, GLU354E, GLU432R, GLU433R, GLU434R, GLY328E, GLY378R, GLY389R, GLY397E, GLY427R, GLY428R, ILE326E, ILE385R, ILE431R, ILE490E, LEU-21E, LEU-22E, LEU-29E, LEU-36R, LEU-4E, LEU358E, LEU391R, LEU398E, LEU401R, LEU444R, LYS447R, LYS451R, MET325E, MET395R, PHE-30E, PHE-33E, PHE423R, PRO-20E, PRO-24E, PRO-3E, SER-34R, SER320E, SER327E, SER422R, THR-32R, THR348E, TRP429R, TYR335E, TYR436R, VAL-38R, VAL331E, VAL351E, VAL353E
• F-G: ALA-25G, ALA356G, ALA360G, ALA82F, ALA88F, ARG219F, ARG220F, ARG224F, ARG357G, ARG75F, ARG76F, ARG85F, ARG91F, ARG92F, ASN73F, ASP-31G, ASP-37G, ASP338G, ASP339G, ASP58F, ASP72F, ASP83F, ASP90F, ASP93F, GLN-26G, GLN51F, GLN80F, GLU-23G, GLU354G, GLU362G, GLU364G, GLU367G, GLU370G, GLU55F, GLY371G, GLY77F, GLY78F, GLY86F, HIS365G, ILE336G, ILE79F, LEU-21G, LEU-22G, LEU-29G, LEU-36G, LEU358G, LEU363G, LEU369G, LEU56F, LYS368G, MET386G, PHE-30G, PHE-33G, PHE222F, PHE355G, PHE81F, PRO-20G, PRO373G, SER-34G, SER-35G, SER54F, THR-32G, THR337G, THR84F, TYR359G, TYR366G, TYR57F, TYR87F, TYR89F, VAL353G, VAL361G, VAL60F, VAL94F
• F-K: ILE7F, PHE6F, PHE6K, PRO4K, PRO9F, SER8F, TYR5F, TYR5K
• F-M: ALA100F, ALA104F, ALA115M, ALA12F, ALA12M, ALA148F, ARG135F, ARG140F, ARG14M, ARG16F, ARG16M, ARG224M, ARG26M, ARG48M, ARG75M, ARG76M, ARG85F, ARG97F, ASN101F, ASN45M, ASN69M, ASN73M, ASP144F, ASP149F, ASP72M, GLN105F, GLN114M, GLN11F, GLN11M, GLN51M, GLN98F, GLU10F, GLU113F, GLU113M, GLU119M, GLU137F, GLU150F, GLU15M, GLU18M, GLU70M, GLY108F, GLY145F, GLY77M, GLY96F, ILE110M, ILE141F, ILE147F, ILE7F, ILE7M, LEU107F, LEU138F, LEU19M, LEU50M, LEU74M, LYS116M, LYS134F, LYS22M, LYS67M, MET13F, MET13M, PHE111F, PHE68M, PHE6F, PHE71M, PHE81F, PRO117M, PRO151F, PRO46M, PRO9F, SER146F, SER47M, SER49M, SER54M, SER8F, THR106F, THR109F, THR112F, THR142F, TYR103F, TYR118M, TYR139F, TYR143F, TYR5M, VAL102F
• F-N: ALA-39N, ALA377N, ALA82F, ALA88F, ARG382N, ARG388N, ARG85F, ARG91F, ARG92F, ARG97F, ASN101F, ASN381N, ASP-31N, ASP-37N, ASP83F, ASP90F, ASP93F, GLN105F, GLN80F, GLN98F, GLU132F, GLU362N, GLU370N, GLY371N, GLY378N, GLY77F, GLY86F, HIS129F, HIS365N, HIS410N, ILE380N, ILE385N, LEU-36N, LEU363N, LEU369N, LEU374N, LEU383N, LYS368N, LYS379N, PHE-33N, PHE376N, PHE81F, PRO373N, SER-34N, SER-35N, THR-32N, THR375N, THR84F, THR95F, TYR366N, TYR87F, TYR89F, VAL-38N, VAL102F, VAL372N, VAL94F
• F-Q: PHE6F, PHE6Q
• F-W: ALA100W, ALA104W, ALA115F, ALA12F, ALA12W, ALA148W, ALA206F, ALA20F, ARG135W, ARG140W, ARG14F, ARG14W, ARG16F, ARG16W, ARG224F, ARG26F, ARG48F, ARG75F, ARG76F, ARG85W, ARG97W, ASN101W, ASN45F, ASN69F, ASN73F, ASP144W, ASP149W, ASP72F, GLN105W, GLN114F, GLN11F, GLN11W, GLN51F, GLN98W, GLU10F, GLU10W, GLU113F, GLU113W, GLU119F, GLU137W, GLU150W, GLU15F, GLU15W, GLU18F, GLU70F, GLY108W, GLY145W, GLY77F, HIS152W, ILE110F, ILE141W, ILE147W, ILE7F, ILE7W, LEU107W, LEU138W, LEU19F, LEU50F, LEU74F, LYS116F, LYS134W, LYS22F, LYS28F, LYS67F, MET13F, MET13W, PHE111W, PHE3W, PHE68F, PHE6F, PHE6W, PHE71F, PHE81W, PRO117F, PRO136W, PRO151W, PRO46F, PRO4W, PRO9F, PRO9W, SER146W, SER17F, SER17W, SER47F, SER49F, SER54F, SER8F, SER8W, THR106W, THR109W, THR112F, THR112W, THR142W, TYR103W, TYR118F, TYR139W, TYR143W, TYR5F, TYR5W, VAL102W
• F-Y: PHE3Y, PHE6F, PHE6Y, PRO9Y, SER2Y, SER8Y, TYR5F
• G-N: ALA-19G, ALA-25G, ALA-39N, ALA-6G, ALA349G, ALA350G, ALA377N, ALA384N, ALA392N, ALA393G, ALA425N, ALA426N, ARG-27G, ARG-27N, ARG-28N, ARG318G, ARG329G, ARG332G, ARG357G, ARG382N, ARG388N, ARG488G, ASN381N, ASN430N, ASP-31N, ASP-37N, ASP330G, ASP424N, GLN-26G, GLN-5G, GLN322G, GLN396G, GLN437N, GLU-23G, GLU354G, GLU432N, GLU433N, GLU434N, GLY328G, GLY378N, GLY389N, GLY397G, GLY427N, GLY428N, HIS-2G, ILE-17G, ILE326G, ILE385N, ILE431N, ILE490G, LEU-21G, LEU-21N, LEU-22G, LEU-29G, LEU-36N, LEU-4G, LEU391N, LEU398G, LEU399N, LEU401N, LEU444N, LYS447N, LYS451N, MET325G, MET395N, PHE-30G, PHE-33G, PHE423N, PRO-20G, PRO-24G, PRO-3G, SER-18G, SER-34N, SER320G, SER327G, SER422N, THR-32N, THR348G, TRP429N, TYR335G, TYR436N, VAL-38N, VAL331G, VAL351G, VAL353G
• G-V: ALA301G, ALA301V, ALA474G, ALA474V, ALA475G, ALA475V, ALA480G, ALA480V, ARG319G, ARG319V, ARG329G, ARG329V, ARG488G, ARG488V, ARG515G, ARG521G, ARG521V, ASN324G, ASN324V, ASP473G, ASP473V, ASP476G, ASP476V, ASP477G, ASP477V, ASP478G, ASP478V, ASP485G, ASP485V, GLN-5G, GLN-5V, GLN322G, GLN322V, GLU519G, GLU519V, GLY-1G, GLY-1V, GLY323G, GLY323V, GLY442G, GLY442V, GLY482G, GLY489G, GLY489V, GLY523V, HIS-2G, HIS-2V, ILE326G, ILE326V, ILE517G, ILE517V, ILE518G, ILE518V, LEU444G, LEU444V, LEU486G, LEU486V, MET325G, MET325V, PHE445G, PHE445V, PRO484G, PRO484V, SER320G, SER320V, SER327G, SER327V, SER441G, SER441V, SER479G, SER479V, SER520G, SER520V, SER522G, SER522V, THR321G, THR321V, THR481G, THR481V, TYR472G, TYR472V, VAL487G, VAL487V
• G-W: ALA-39G, ALA377G, ALA82W, ALA88W, ARG382G, ARG388G, ARG85W, ARG91W, ARG92W, ARG97W, ASN101W, ASN381G, ASP-31G, ASP-37G, ASP83W, ASP90W, ASP93W, GLN105W, GLN80W, GLN98W, GLU132W, GLU362G, GLU370G, GLY371G, GLY378G, GLY77W, GLY86W, HIS129W, HIS365G, HIS410G, ILE380G, ILE385G, LEU-36G, LEU363G, LEU369G, LEU374G, LEU383G, LYS368G, LYS379G, PHE-33G, PHE376G, PHE81W, PRO373G, SER-34G, SER-35G, THR375G, THR84W, THR95W, TYR366G, TYR87W, TYR89W, VAL-38G, VAL102W, VAL372G, VAL94W
• G-X: ALA-19X, ALA-25X, ALA-39G, ALA349X, ALA350X, ALA352X, ALA377G, ALA384G, ALA392G, ALA393X, ALA394G, ALA425G, ALA426G, ARG-27G, ARG-27X, ARG-28G, ARG318X, ARG329X, ARG332X, ARG357X, ARG382G, ARG388G, ARG488X, ASN381G, ASN430G, ASP-31G, ASP-37G, ASP330X, ASP424G, GLN-26X, GLN-5X, GLN322X, GLN396X, GLN437G, GLU-23X, GLU354X, GLU432G, GLU433G, GLU434G, GLY328X, GLY378G, GLY389G, GLY397X, GLY427G, GLY428G, ILE-17G, ILE-17X, ILE326X, ILE385G, ILE431G, ILE490X, LEU-21X, LEU-22X, LEU-29X, LEU-36G, LEU-4X, LEU358X, LEU391G, LEU398X, LEU399G, LEU401G, LEU444G, LYS447G, LYS451G, MET325X, MET386G, MET395G, PHE-30X, PHE-33X, PHE355X, PHE423G, PRO-20X, PRO-24X, PRO-3X, SER-18X, SER-34G, SER320X, SER327X, SER422G, THR-32G, THR348X, TRP429G, TYR335X, TYR436G, VAL-38G, VAL331X, VAL351X, VAL353X, VAL387G
• G-2: ALA4462, ALA446G, ALA4702, ALA470G, ALA4742, ALA474G, ALA4752, ALA475G, ARG465G, ARG5212, ARG521G, ASP4732, ASP473G, ASP4762, ASP476G, ASP4772, ASP477G, ASP4782, GLN4562, GLN456G, GLU4342, GLU434G, GLU4692, GLU469G, GLY442G, ILE5172, ILE517G, LEU4442, LEU444G, LEU4532, LEU453G, LYS4472, LYS447G, LYS4512, LYS451G, LYS4522, LYS452G, MET4502, MET450G, PHE4452, PHE445G, SER4432, SER443G, SER4482, SER448G, SER4492, SER449G, TYR4362, TYR436G, TYR4722, TYR472G, VAL4662, VAL466G
• H-L: ALA301H, ALA301L, ALA474H, ALA474L, ALA475H, ALA475L, ALA480H, ALA480L, ARG319H, ARG319L, ARG329H, ARG329L, ARG488H, ARG488L, ARG515H, ARG521H, ARG521L, ASN324H, ASN324L, ASP473H, ASP473L, ASP476H, ASP476L, ASP477H, ASP477L, ASP478H, ASP478L, ASP485H, ASP485L, GLN-5H, GLN322H, GLN322L, GLU519H, GLU519L, GLY-1H, GLY-1L, GLY323H, GLY323L, GLY442H, GLY442L, GLY482H, GLY489H, GLY489L, GLY523L, HIS-2H, HIS-2L, ILE326H, ILE326L, ILE517H, ILE517L, ILE518H, ILE518L, LEU444H, LEU444L, LEU486H, LEU486L, MET325H, MET325L, PHE445H, PHE445L, SER320H, SER320L, SER327H, SER327L, SER441H, SER441L, SER479H, SER479L, SER520H, SER520L, SER522H, SER522L, THR321H, THR321L, THR481H, THR481L, TYR472H, TYR472L, VAL487H, VAL487L
• H-P: ALA-19H, ALA-25H, ALA-39P, ALA-6H, ALA349H, ALA350H, ALA377P, ALA384P, ALA393H, ALA394P, ALA425P, ALA426P, ARG-27H, ARG-27P, ARG-28P, ARG318H, ARG329H, ARG332H, ARG357H, ARG382P, ARG388P, ARG488H, ASN381P, ASN430P, ASP-31P, ASP-37P, ASP330H, ASP424P, GLN-26H, GLN-5H, GLN322H, GLN396H, GLN437P, GLU-23H, GLU354H, GLU432P, GLU433P, GLU434P, GLY328H, GLY378P, GLY389P, GLY397H, GLY427P, GLY428P, HIS-2H, ILE326H, ILE385P, ILE431P, ILE490H, LEU-21H, LEU-21P, LEU-22H, LEU-29H, LEU-36P, LEU-4H, LEU358H, LEU391P, LEU398H, LEU399P, LEU401P, LEU444P, LYS447P, LYS451P, MET325H, MET395P, PHE-30H, PHE-33H, PHE355H, PHE423P, PRO-20H, PRO-24H, PRO-3H, SER-34P, SER320H, SER327H, SER422P, THR-32P, THR348H, TRP429P, TYR335H, TYR436P, VAL-38P, VAL331H, VAL351H, VAL353H, VAL387P
• I-J: ALA-25J, ALA356J, ALA360J, ALA82I, ALA88I, ARG-27J, ARG219I, ARG220I, ARG224I, ARG357J, ARG75I, ARG76I, ARG85I, ARG91I, ARG92I, ASN73I, ASP-31J, ASP-37J, ASP338J, ASP339J, ASP58I, ASP72I, ASP83I, ASP90I, GLN-26J, GLN51I, GLN80I, GLU-23J, GLU354J, GLU362J, GLU364J, GLU367J, GLU370J, GLU55I, GLY371J, GLY77I, GLY78I, GLY86I, HIS365J, ILE336J, ILE79I, LEU-21J, LEU-22J, LEU-29J, LEU-36J, LEU358J, LEU363J, LEU369J, LEU56I, LYS368J, MET386J, PHE-30J, PHE-33J, PHE222I, PHE355J, PHE81I, PRO-20J, PRO373J, SER-34J, SER-35J, SER49I, SER54I, THR337J, THR84I, TYR359J, TYR366J, TYR57I, TYR87I, TYR89I, VAL353J, VAL361J, VAL60I, VAL94I
• I-S: ALA100S, ALA104S, ALA115I, ALA12I, ALA12S, ALA148S, ALA20I, ARG135S, ARG140S, ARG14I, ARG14S, ARG16I, ARG16S, ARG21I, ARG224I, ARG26I, ARG48I, ARG75I, ARG76I, ARG85S, ARG97S, ASN101S, ASN69I, ASN73I, ASP144S, ASP149S, ASP72I, GLN105S, GLN114I, GLN11I, GLN11S, GLN51I, GLN98S, GLU10I, GLU10S, GLU113I, GLU113S, GLU119I, GLU137S, GLU150S, GLU15I, GLU15S, GLU18I, GLU70I, GLY108S, GLY145S, GLY23I, GLY77I, ILE110I, ILE141S, ILE147S, ILE7I, ILE7S, LEU107S, LEU138S, LEU19I, LEU50I, LEU74I, LYS116I, LYS134S, LYS22I, LYS67I, MET13I, MET13S, PHE111S, PHE68I, PHE6I, PHE6S, PHE71I, PHE81S, PRO117I, PRO151S, PRO46I, PRO9I, PRO9S, SER146S, SER17I, SER47I, SER49I, SER54I, SER8I, SER8S, THR106S, THR109S, THR112I, THR112S, THR142S, TYR103S, TYR118I, TYR139S, TYR143S, TYR5I, VAL102S
• I-U: ILE7I, ILE7U, PHE6I, TYR5I, TYR5U
• I-1: GLN111, ILE71, PHE61, PHE6I, SER81, TYR5I
• J-R: ALA301J, ALA301R, ALA474J, ALA474R, ALA475J, ALA475R, ALA480J, ALA480R, ARG319J, ARG319R, ARG329J, ARG329R, ARG488J, ARG488R, ARG521J, ARG521R, ASN324J, ASN324R, ASP473J, ASP473R, ASP476J, ASP476R, ASP477J, ASP477R, ASP478J, ASP478R, ASP485J, ASP485R, GLN-5J, GLN322J, GLN322R, GLU519J, GLU519R, GLY-1J, GLY-1R, GLY323J, GLY323R, GLY442J, GLY442R, GLY489J, HIS-2J, HIS-2R, ILE326J, ILE326R, ILE517J, ILE517R, ILE518J, ILE518R, LEU444J, LEU486J, LEU486R, MET325J, MET325R, PHE445J, PHE445R, PRO484J, SER320J, SER320R, SER327J, SER327R, SER441J, SER441R, SER479J, SER479R, SER520J, SER520R, SER522J, SER522R, THR321J, THR321R, THR481J, THR481R, TYR472J, TYR472R, VAL487J, VAL487R
• J-S: ALA-39J, ALA377J, ALA82S, ALA88S, ARG382J, ARG388J, ARG85S, ARG91S, ARG92S, ARG97S, ASN101S, ASN381J, ASP-31J, ASP-37J, ASP83S, ASP90S, ASP93S, GLN80S, GLN98S, GLU132S, GLU362J, GLU370J, GLY371J, GLY378J, GLY77S, GLY86S, HIS129S, HIS365J, HIS410J, ILE380J, ILE385J, LEU-36J, LEU363J, LEU369J, LEU374J, LEU383J, LYS368J, LYS379J, PHE-33J, PHE376J, PHE81S, PRO373J, SER-34J, SER-35J, THR-32J, THR375J, THR84S, THR95S, TYR366J, TYR87S, TYR89S, VAL-38J, VAL102S, VAL372J, VAL94S
• J-T: ALA-19T, ALA-25T, ALA-39J, ALA349T, ALA350T, ALA377J, ALA384J, ALA392J, ALA393J, ALA393T, ALA394J, ALA425J, ALA426J, ARG-27J, ARG-27T, ARG-28J, ARG318T, ARG329T, ARG332T, ARG357T, ARG382J, ARG388J, ARG488T, ASN381J, ASN430J, ASP-31J, ASP-37J, ASP330T, ASP424J, GLN-26T, GLN-5T, GLN322T, GLN396J, GLN396T, GLN437J, GLU-23T, GLU354T, GLU432J, GLU433J, GLU434J, GLY-15J, GLY328T, GLY378J, GLY389J, GLY397T, GLY427J, GLY428J, ILE-17J, ILE-17T, ILE326T, ILE385J, ILE431J, ILE490T, LEU-21J, LEU-21T, LEU-22T, LEU-29T, LEU-36J, LEU-4T, LEU358T, LEU391J, LEU398T, LEU401J, LEU444J, LYS447J, LYS451J, MET325T, MET386J, MET395J, PHE-30J, PHE-30T, PHE-33T, PHE355T, PHE423J, PRO-20T, PRO-24T, PRO-3T, SER-16J, SER-16T, SER-18T, SER-34J, SER320T, SER327T, SER422J, THR-32J, THR348T, TRP429J, TYR335T, TYR436J, VAL-38J, VAL331T, VAL351T, VAL353T
• J-Z: ALA446J, ALA446Z, ALA470J, ALA470Z, ALA474J, ALA474Z, ALA475J, ALA475Z, ARG465J, ARG521J, ARG521Z, ASP473J, ASP473Z, ASP476J, ASP476Z, ASP477J, ASP477Z, ASP478J, GLN456J, GLN456Z, GLU434J, GLU434Z, GLU469J, GLU469Z, GLY442J, GLY442Z, ILE517J, LEU444J, LEU444Z, LEU453J, LEU453Z, LYS447J, LYS447Z, LYS451J, LYS451Z, LYS452J, LYS452Z, MET450J, MET450Z, PHE445J, PHE445Z, SER441J, SER441Z, SER443J, SER443Z, SER448J, SER448Z, SER449J, SER449Z, TYR436Z, TYR454Z, TYR472J, TYR472Z, VAL466J, VAL466Z
• K-L: ALA-25L, ALA356L, ALA360L, ALA82K, ALA88K, ARG-27L, ARG219K, ARG220K, ARG224K, ARG357L, ARG75K, ARG76K, ARG85K, ARG91K, ARG92K, ASN73K, ASP-31L, ASP-37L, ASP338L, ASP339L, ASP58K, ASP72K, ASP83K, ASP90K, GLN-26L, GLN51K, GLN80K, GLU-23L, GLU354L, GLU362L, GLU364L, GLU367L, GLU370L, GLU55K, GLY371L, GLY77K, GLY78K, GLY86K, HIS365L, ILE79K, LEU-21L, LEU-22L, LEU-29L, LEU-36L, LEU358L, LEU363L, LEU369L, LEU56K, LYS368L, MET386L, PHE-30L, PHE-33L, PHE222K, PHE355L, PHE81K, PRO-20L, PRO373L, SER-34L, SER-35L, SER54K, THR-32L, THR337L, THR84K, TYR359L, TYR366L, TYR57K, TYR87K, TYR89K, VAL353L, VAL361L, VAL372L, VAL60K, VAL94K
• K-M: ALA100M, ALA104M, ALA115K, ALA12K, ALA12M, ALA148M, ALA20K, ARG135M, ARG140M, ARG14K, ARG14M, ARG16K, ARG16M, ARG21K, ARG224K, ARG48K, ARG75K, ARG76K, ARG85M, ARG97M, ASN101M, ASN69K, ASN73K, ASP144M, ASP149M, ASP72K, GLN105M, GLN114K, GLN11K, GLN11M, GLN51K, GLN98M, GLU10K, GLU10M, GLU113K, GLU113M, GLU119K, GLU137M, GLU150M, GLU15K, GLU15M, GLU18K, GLU70K, GLY108M, GLY145M, GLY77K, HIS152M, ILE110K, ILE141M, ILE147M, ILE7K, ILE7M, LEU107M, LEU138M, LEU19K, LEU50K, LEU74K, LYS116K, LYS22K, LYS67K, MET13K, MET13M, PHE111K, PHE111M, PHE3M, PHE68K, PHE6K, PHE6M, PHE71K, PHE81M, PRO117K, PRO136M, PRO151M, PRO46K, PRO4K, PRO4M, PRO9K, PRO9M, SER146M, SER17K, SER47K, SER49K, SER54K, SER8K, SER8M, THR106M, THR109M, THR112K, THR112M, THR142M, TYR103M, TYR118K, TYR139M, TYR143M, TYR5K, TYR5M, VAL102M
• K-Q: GLN11K, ILE7K, PHE3Q, PHE6K, PHE6Q, PRO4K, PRO4Q, PRO9K, SER8K, TYR5K, TYR5Q
• K-W: ALA115K, ARG16K, GLN114K, ILE7K, ILE7W, LEU19K, LYS116K, PHE3W, PHE6K, PHE6W, PRO117K, PRO4K, PRO4W, TYR5K, TYR5W
• L-M: ALA377L, ALA384L, ALA82M, ALA88M, ARG382L, ARG388L, ARG85M, ARG91M, ARG92M, ARG97M, ASN101M, ASN381L, ASP-31L, ASP-37L, ASP83M, ASP90M, ASP93M, GLN105M, GLN80M, GLN98M, GLU132M, GLU362L, GLU370L, GLY371L, GLY378L, GLY77M, GLY86M, HIS129M, HIS365L, HIS410L, ILE380L, ILE385L, LEU-36L, LEU363L, LEU369L, LEU374L, LEU383L, LYS368L, LYS379L, PHE-33L, PHE376L, PHE81M, PRO373L, SER-34L, SER-35L, THR-32L, THR375L, THR84M, THR95M, TYR366L, TYR87M, TYR89M, VAL-38L, VAL102M, VAL372L, VAL94M
• L-N: ALA-19N, ALA-25N, ALA349N, ALA350N, ALA377L, ALA384L, ALA392L, ALA393L, ALA393N, ALA425L, ALA426L, ARG-27N, ARG-28L, ARG318N, ARG329N, ARG332N, ARG357N, ARG382L, ARG388L, ARG488N, ASN381L, ASN390L, ASN430L, ASP-31L, ASP-37L, ASP330N, ASP424L, ASP485N, GLN-26N, GLN-5N, GLN322N, GLN396N, GLN437L, GLU-23N, GLU354N, GLU432L, GLU433L, GLU434L, GLY328N, GLY378L, GLY389L, GLY397N, GLY427L, GLY428L, HIS-2N, ILE-17N, ILE326N, ILE385L, ILE431L, ILE490N, LEU-21L, LEU-21N, LEU-22N, LEU-29N, LEU-36L, LEU-4N, LEU358N, LEU391L, LEU398N, LEU401L, LEU444L, LYS447L, LYS451L, MET325N, MET386L, MET395L, PHE-30N, PHE-33N, PHE355N, PHE423L, PRO-20N, PRO-24N, PRO-3N, SER-16N, SER-18L, SER-18N, SER-34L, SER320N, SER327N, SER422L, THR-32L, THR348N, TRP429L, TYR335N, TYR436L, VAL-38L, VAL331N, VAL351N, VAL353N, VAL387L
• L-P: ALA446L, ALA446P, ALA470L, ALA470P, ALA474L, ALA474P, ALA475L, ALA475P, ARG465P, ARG521L, ARG521P, ASP473L, ASP473P, ASP476L, ASP476P, ASP477L, ASP477P, ASP478L, ASP478P, GLN456L, GLN456P, GLU434L, GLU469L, GLU469P, GLY442L, GLY442P, ILE517L, ILE517P, LEU444L, LEU444P, LEU453L, LEU453P, LYS447L, LYS447P, LYS451L, LYS451P, LYS452L, LYS452P, MET450L, MET450P, PHE445L, PHE445P, SER441L, SER441P, SER443L, SER443P, SER448L, SER448P, SER449L, SER449P, TYR436P, TYR454L, TYR454P, TYR472L, TYR472P, VAL466L, VAL466P
• M-N: ALA-19N, ALA-25N, ALA356N, ALA360N, ALA82M, ALA88M, ARG-27N, ARG219M, ARG220M, ARG224M, ARG357N, ARG75M, ARG76M, ARG85M, ARG91M, ARG92M, ASN73M, ASP-31N, ASP-37N, ASP338N, ASP339N, ASP58M, ASP72M, ASP83M, ASP90M, ASP93M, GLN-26N, GLN51M, GLN80M, GLU-23N, GLU354N, GLU362N, GLU364N, GLU367N, GLU370N, GLU55M, GLY371N, GLY77M, GLY78M, GLY86M, HIS365N, ILE336N, ILE79M, LEU-21N, LEU-22N, LEU-29N, LEU-36N, LEU358N, LEU363N, LEU369N, LEU56M, LYS368N, MET386N, PHE-30N, PHE-33N, PHE222M, PHE355N, PHE81M, PRO-20N, PRO-24N, PRO373N, SER-34N, SER-35N, SER49M, SER54M, THR337N, THR84M, TYR359N, TYR366N, TYR57M, TYR87M, TYR89M, VAL353N, VAL361N, VAL60M, VAL94M
• M-Q: ALA115Q, ARG16Q, GLN114Q, GLU113Q, ILE7M, LEU19Q, LYS116Q, PHE3M, PHE6M, PHE6Q, PRO117Q, PRO4M, PRO4Q, SER2M, SER8M, THR112Q, TYR5M, TYR5Q
• M-W: ALA115M, ALA12M, ARG14M, ARG16M, GLN114M, GLN11M, GLU10M, GLU113M, GLU15M, ILE110M, ILE7M, LEU19M, LYS116M, MET13M, PHE111M, PHE3W, PHE6M, PHE6W, PRO117M, PRO4W, PRO9M, SER8M, THR112M, TYR5M, TYR5W
• M-Y: ALA115Y, SER2M
• N-P: ALA301N, ALA301P, ALA474N, ALA474P, ALA475N, ALA475P, ALA480N, ALA480P, ARG319N, ARG319P, ARG329N, ARG329P, ARG488N, ARG488P, ARG521N, ARG521P, ASN324N, ASN324P, ASP473N, ASP473P, ASP476N, ASP476P, ASP477N, ASP477P, ASP478N, ASP478P, ASP485N, ASP485P, GLN-5N, GLN-5P, GLN322N, GLN322P, GLU519N, GLU519P, GLY-1N, GLY-1P, GLY323N, GLY323P, GLY442N, GLY442P, GLY482P, GLY489N, GLY489P, GLY523N, HIS-2N, HIS-2P, ILE326N, ILE326P, ILE517N, ILE517P, ILE518N, ILE518P, LEU444N, LEU444P, LEU486N, LEU486P, MET325N, MET325P, PHE445N, PHE445P, PRO484N, PRO484P, SER320N, SER320P, SER327N, SER327P, SER441N, SER441P, SER479N, SER479P, SER520N, SER520P, SER522N, SER522P, THR321N, THR321P, THR481N, THR481P, TYR472N, TYR472P, VAL487N, VAL487P
• N-V: ALA446N, ALA446V, ALA470N, ALA470V, ALA474N, ALA474V, ALA475N, ALA475V, ARG465V, ARG521N, ARG521V, ASP473N, ASP473V, ASP476N, ASP476V, ASP477N, ASP477V, ASP478N, ASP478V, GLN456N, GLN456V, GLU434N, GLU434V, GLU469N, GLU469V, GLY442N, GLY442V, ILE517N, ILE517V, LEU444N, LEU444V, LEU453N, LEU453V, LYS447N, LYS447V, LYS451N, LYS451V, LYS452N, LYS452V, MET450N, MET450V, PHE445N, PHE445V, SER441N, SER443N, SER443V, SER448N, SER448V, SER449N, SER449V, TYR436V, TYR454V, TYR472N, TYR472V, VAL466N, VAL466V
• O-P: ALA-25P, ALA356P, ALA360P, ALA82O, ALA88O, ARG-27P, ARG219O, ARG220O, ARG224O, ARG357P, ARG75O, ARG76O, ARG85O, ARG91O, ARG92O, ASN73O, ASP-31P, ASP-37P, ASP338P, ASP339P, ASP58O, ASP72O, ASP83O, ASP90O, ASP93O, GLN-26P, GLN51O, GLN80O, GLU-23P, GLU354P, GLU362P, GLU364P, GLU367P, GLU370P, GLU55O, GLY371P, GLY77O, GLY78O, GLY86O, HIS365P, ILE79O, LEU-21P, LEU-22P, LEU-29P, LEU-36P, LEU358P, LEU363P, LEU369P, LEU56O, LYS368P, MET386P, PHE-30P, PHE-33P, PHE222O, PHE355P, PHE81O, PRO-20P, PRO373P, SER-34P, SER-35P, SER54O, THR-32P, THR337P, THR84O, TYR359P, TYR366P, TYR57O, TYR87O, TYR89O, VAL353P, VAL361P, VAL60O, VAL94O
• O-U: ALA100O, ALA104O, ALA115U, ALA12O, ALA12U, ALA148O, ALA20U, ARG135O, ARG140O, ARG14O, ARG14U, ARG16O, ARG16U, ARG224U, ARG26U, ARG48U, ARG75U, ARG76U, ARG85O, ARG97O, ASN101O, ASN45U, ASN69U, ASN73U, ASP144O, ASP149O, ASP72U, GLN105O, GLN114U, GLN11O, GLN11U, GLN51U, GLN98O, GLU10O, GLU113O, GLU113U, GLU119U, GLU126O, GLU137O, GLU150O, GLU15U, GLU18U, GLU70U, GLY108O, GLY145O, GLY23U, GLY77U, GLY96O, ILE110U, ILE141O, ILE147O, ILE7O, ILE7U, LEU107O, LEU138O, LEU19U, LEU50U, LEU74U, LYS116U, LYS22U, LYS67U, MET13O, MET13U, PHE111O, PHE68U, PHE71U, PHE81O, PRO117U, PRO151O, PRO46U, PRO9O, SER146O, SER17U, SER47U, SER49U, SER54U, SER8O, SER8U, THR106O, THR109O, THR112O, THR142O, THR95O, TYR103O, TYR118U, TYR139O, TYR143O, VAL102O
• O-V: ALA-39V, ALA377V, ALA82O, ALA88O, ARG382V, ARG388V, ARG85O, ARG91O, ARG92O, ARG97O, ASN101O, ASN381V, ASP-31V, ASP-37V, ASP83O, ASP90O, ASP93O, GLN105O, GLN80O, GLN98O, GLU132O, GLU362V, GLU370V, GLY371V, GLY378V, GLY77O, GLY86O, HIS129O, HIS365V, HIS410V, ILE380V, ILE385V, LEU-36V, LEU363V, LEU369V, LEU374V, LEU383V, LYS368V, LYS379V, PHE-33V, PHE376V, PHE81O, PRO373V, SER-34V, SER-35V, THR-32V, THR375V, THR84O, THR95O, TYR366V, TYR87O, TYR89O, VAL-38V, VAL102O, VAL372V, VAL94O
• O-1: GLN11O, GLU10O, ILE7O, PHE61, PRO9O, SER8O, TYR51
• P-V: ALA-19P, ALA-25P, ALA-39V, ALA349P, ALA350P, ALA377V, ALA384V, ALA392V, ALA393P, ALA393V, ALA425V, ALA426V, ARG-27P, ARG-27V, ARG-28V, ARG318P, ARG329P, ARG332P, ARG357P, ARG382V, ARG388V, ARG488P, ASN381V, ASN390V, ASN430V, ASP-31V, ASP-37V, ASP330P, ASP424V, GLN-26P, GLN-5P, GLN322P, GLN396P, GLN437V, GLU-23P, GLU354P, GLU362V, GLU432V, GLU433V, GLU434V, GLY328P, GLY378V, GLY389V, GLY397P, GLY427V, GLY428V, ILE-17P, ILE326P, ILE385V, ILE431V, ILE490P, LEU-21P, LEU-22P, LEU-29P, LEU-36V, LEU-4P, LEU358P, LEU391V, LEU398P, LEU401V, LEU444V, LYS447V, LYS451V, MET325P, MET386V, MET395V, PHE-30P, PHE-33P, PHE355P, PHE423V, PRO-20P, PRO-24P, PRO-3P, SER-18P, SER-34V, SER320P, SER327P, SER422V, THR-32V, THR348P, TRP429V, TYR335P, TYR436V, VAL-38V, VAL331P, VAL351P, VAL353P
• Q-R: ALA-25R, ALA356R, ALA360R, ALA82Q, ALA88Q, ARG-27R, ARG219Q, ARG220Q, ARG224Q, ARG357R, ARG75Q, ARG76Q, ARG85Q, ARG91Q, ARG92Q, ASP-31R, ASP-37R, ASP338R, ASP339R, ASP58Q, ASP72Q, ASP83Q, ASP90Q, GLN-26R, GLN51Q, GLN80Q, GLU-23R, GLU354R, GLU362R, GLU364R, GLU367R, GLU370R, GLU55Q, GLY371R, GLY77Q, GLY78Q, GLY86Q, HIS365R, ILE79Q, LEU-21R, LEU-22R, LEU-29R, LEU-36R, LEU358R, LEU363R, LEU369R, LEU56Q, LYS368R, MET386R, PHE-30R, PHE-33R, PHE222Q, PHE355R, PHE81Q, PRO-20R, PRO373R, SER-34R, SER-35R, SER54Q, THR-32R, THR337R, THR84Q, TYR359R, TYR366R, TYR57Q, TYR87Q, TYR89Q, VAL353R, VAL361R, VAL60Q, VAL94Q
• Q-Y: ALA100Q, ALA104Q, ALA115Y, ALA12Q, ALA12Y, ALA148Q, ALA20Y, ARG135Q, ARG140Q, ARG14Q, ARG14Y, ARG16Q, ARG16Y, ARG21Y, ARG224Y, ARG26Y, ARG48Y, ARG75Y, ARG76Y, ARG85Q, ARG97Q, ASN101Q, ASN69Y, ASN73Y, ASP144Q, ASP149Q, ASP72Y, GLN105Q, GLN114Q, GLN114Y, GLN11Q, GLN11Y, GLN51Y, GLN98Q, GLU10Q, GLU113Q, GLU113Y, GLU119Y, GLU137Q, GLU150Q, GLU15Y, GLU18Y, GLU70Y, GLY108Q, GLY145Q, GLY77Y, ILE110Y, ILE141Q, ILE147Q, ILE7Q, ILE7Y, LEU107Q, LEU19Y, LEU50Y, LEU74Y, LYS116Y, LYS22Y, LYS28Y, LYS67Y, MET13Q, MET13Y, PHE111Q, PHE68Y, PHE6Q, PHE6Y, PHE71Y, PHE81Q, PRO117Y, PRO151Q, PRO46Y, PRO9Q, PRO9Y, SER146Q, SER17Y, SER47Y, SER49Y, SER54Y, SER8Q, SER8Y, THR106Q, THR109Q, THR112Q, THR142Q, TYR103Q, TYR118Y, TYR139Q, TYR143Q, TYR5Q, TYR5Y, VAL102Q
• Q-Z: ALA377Z, ALA82Q, ALA88Q, ARG382Z, ARG388Z, ARG85Q, ARG91Q, ARG92Q, ARG97Q, ASN101Q, ASN381Z, ASP-31Z, ASP-37Z, ASP83Q, ASP90Q, ASP93Q, GLN80Q, GLN98Q, GLU362Z, GLU370Z, GLY371Z, GLY378Z, GLY77Q, GLY78Q, GLY86Q, HIS129Q, HIS365Z, HIS410Z, ILE380Z, ILE385Z, LEU-36Z, LEU363Z, LEU369Z, LEU374Z, LYS379Z, PHE-33Z, PHE376Z, PHE81Q, PRO373Z, SER-34Z, SER-35Z, THR-32Z, THR375Z, THR84Q, THR95Q, TYR366Z, TYR87Q, TYR89Q, VAL-38Z, VAL102Q, VAL372Z, VAL94Q
• R-Z: ALA-19R, ALA-25R, ALA349R, ALA350R, ALA377Z, ALA384Z, ALA393R, ALA425Z, ALA426Z, ARG-27R, ARG-27Z, ARG-28Z, ARG318R, ARG329R, ARG332R, ARG357R, ARG382Z, ARG388Z, ARG488R, ASN381Z, ASN430Z, ASP-31Z, ASP-37Z, ASP330R, ASP424Z, GLN-26R, GLN322R, GLN396R, GLN437Z, GLU-23R, GLU354R, GLU432Z, GLU433Z, GLU434Z, GLY328R, GLY378Z, GLY389Z, GLY397R, GLY427Z, GLY428Z, ILE326R, ILE385Z, ILE431Z, ILE490R, LEU-21R, LEU-21Z, LEU-22R, LEU-29R, LEU-36Z, LEU358R, LEU391Z, LEU398R, LEU401Z, LEU444Z, LYS447Z, LYS451Z, MET325R, MET386Z, MET395Z, PHE-30R, PHE-30Z, PHE-33R, PHE355R, PHE423Z, PRO-20R, PRO-24R, PRO-3R, SER-34Z, SER320R, SER327R, SER422Z, THR-32Z, THR348R, TRP429Z, TYR335R, TYR436Z, VAL-38Z, VAL331R, VAL351R, VAL353R
• S-T: ALA-25T, ALA356T, ALA360T, ALA82S, ALA88S, ARG-27T, ARG217S, ARG219S, ARG220S, ARG224S, ARG357T, ARG75S, ARG76S, ARG85S, ARG91S, ARG92S, ASN73S, ASP-31T, ASP-37T, ASP338T, ASP339T, ASP58S, ASP72S, ASP83S, ASP90S, ASP93S, GLN-26T, GLN51S, GLN80S, GLU-23T, GLU354T, GLU362T, GLU364T, GLU367T, GLU370T, GLU55S, GLY371T, GLY77S, GLY78S, GLY86S, HIS365T, ILE79S, LEU-21T, LEU-22T, LEU-29T, LEU-36T, LEU358T, LEU363T, LEU369T, LEU56S, LYS368T, MET386T, PHE-30T, PHE-33T, PHE222S, PHE355T, PHE81S, PRO-20T, PRO373T, SER-34T, SER-35T, SER54S, THR-32T, THR337T, THR84S, TYR359T, TYR366T, TYR57S, TYR87S, TYR89S, VAL353T, VAL361T, VAL60S, VAL94S
• S-U: ALA115S, ALA12S, ARG14S, ARG16S, GLN114S, GLN11S, GLU10S, GLU15S, ILE7S, LEU19S, LYS116S, PHE6S, PHE6U, PRO117S, PRO9S, SER8S, TYR5U
• S-1: ALA1001, ALA1041, ALA115S, ALA121, ALA12S, ALA1481, ALA20S, ARG1351, ARG1401, ARG141, ARG14S, ARG161, ARG16S, ARG48S, ARG75S, ARG76S, ARG851, ARG971, ASN1011, ASN69S, ASN73S, ASP1441, ASP1491, ASP72S, GLN1051, GLN111, GLN1141, GLN114S, GLN11S, GLN51S, GLN981, GLU101, GLU1131, GLU113S, GLU119S, GLU1371, GLU1501, GLU15S, GLU18S, GLU70S, GLY1081, GLY1451, GLY77S, ILE110S, ILE1411, ILE1471, ILE71, ILE7S, LEU1071, LEU1381, LEU19S, LEU50S, LEU74S, LYS116S, LYS22S, LYS67S, MET131, MET13S, PHE1111, PHE61, PHE68S, PHE71S, PHE811, PRO117S, PRO1511, PRO46S, PRO91, SER1461, SER17S, SER47S, SER49S, SER81, THR1061, THR1091, THR1121, THR1421, TYR1031, TYR118S, TYR1391, TYR1431, VAL1021
• T-X: ALA446T, ALA446X, ALA470T, ALA470X, ALA474T, ALA474X, ALA475T, ALA475X, ARG521T, ARG521X, ASP473T, ASP473X, ASP476T, ASP476X, ASP477T, ASP477X, ASP478T, ASP478X, GLN456T, GLN456X, GLU434T, GLU434X, GLU469T, GLU469X, GLY442X, ILE517X, LEU444T, LEU444X, LEU453T, LEU453X, LYS447T, LYS447X, LYS451T, LYS451X, LYS452T, LYS452X, MET450T, MET450X, PHE445T, PHE445X, SER443T, SER443X, SER448T, SER448X, SER449T, SER449X, TYR436X, TYR454X, TYR472T, TYR472X, VAL466T, VAL466X
• T-Z: ALA301T, ALA301Z, ALA474T, ALA474Z, ALA475T, ALA475Z, ALA480T, ALA480Z, ARG319T, ARG319Z, ARG329T, ARG329Z, ARG488T, ARG488Z, ARG521T, ARG521Z, ASN324T, ASN324Z, ASP473T, ASP473Z, ASP476T, ASP476Z, ASP477T, ASP477Z, ASP478T, ASP478Z, ASP485T, ASP485Z, GLN322T, GLN322Z, GLU519T, GLU519Z, GLY-1T, GLY-1Z, GLY323T, GLY323Z, GLY442T, GLY442Z, GLY482Z, GLY489Z, HIS-2T, HIS-2Z, ILE326T, ILE326Z, ILE517T, ILE517Z, ILE518T, ILE518Z, LEU444T, LEU444Z, LEU486T, LEU486Z, MET325T, MET325Z, PHE445T, PHE445Z, PRO484T, SER320T, SER320Z, SER327T, SER327Z, SER441T, SER441Z, SER479T, SER479Z, SER520T, SER520Z, SER522T, SER522Z, THR321T, THR321Z, THR481T, THR481Z, TYR472T, TYR472Z, VAL487T, VAL487Z
• T-1: ALA377T, ALA821, ALA881, ARG382T, ARG388T, ARG851, ARG911, ARG921, ARG971, ASN1011, ASN381T, ASP-31T, ASP-37T, ASP831, ASP901, ASP931, GLN1051, GLN801, GLN981, GLU1321, GLU362T, GLU370T, GLY371T, GLY378T, GLY771, GLY861, HIS1291, HIS365T, HIS410T, ILE380T, ILE385T, LEU-36T, LEU363T, LEU369T, LEU374T, LEU383T, LYS368T, LYS379T, PHE-33T, PHE376T, PHE811, PRO373T, SER-34T, SER-35T, THR-32T, THR375T, THR841, THR951, TYR366T, TYR871, TYR891, VAL-38T, VAL1021, VAL372T, VAL941
• T-2: ALA-252, ALA3492, ALA3502, ALA3522, ALA377T, ALA384T, ALA392T, ALA3932, ALA394T, ALA425T, ALA426T, ARG-272, ARG-27T, ARG-28T, ARG3182, ARG3292, ARG3322, ARG3572, ARG382T, ARG388T, ARG4882, ASN381T, ASN390T, ASN430T, ASP-31T, ASP-37T, ASP3302, ASP424T, GLN-262, GLN-52, GLN3222, GLN3962, GLN437T, GLU-232, GLU3542, GLU432T, GLU433T, GLU434T, GLY3282, GLY378T, GLY389T, GLY3972, GLY427T, GLY428T, ILE3262, ILE385T, ILE431T, ILE4902, LEU-212, LEU-21T, LEU-222, LEU-292, LEU-36T, LEU-42, LEU3582, LEU391T, LEU3982, LEU399T, LEU401T, LEU444T, LYS447T, LYS451T, MET3252, MET386T, MET395T, PHE-302, PHE-332, PHE3552, PHE423T, PRO-202, PRO-242, PRO-32, SER-34T, SER3202, SER3272, SER422T, THR-32T, THR3482, TRP429T, TYR3352, TYR436T, VAL-38T, VAL3312, VAL3512, VAL3532, VAL387T
• U-V: ALA-25V, ALA356V, ALA360V, ALA82U, ALA88U, ARG-27V, ARG217U, ARG219U, ARG220U, ARG224U, ARG357V, ARG75U, ARG76U, ARG85U, ARG91U, ARG92U, ASN73U, ASP-31V, ASP-37V, ASP338V, ASP339V, ASP58U, ASP72U, ASP83U, ASP90U, GLN-26V, GLN51U, GLN80U, GLU-23V, GLU354V, GLU362V, GLU364V, GLU367V, GLU370V, GLU55U, GLY371V, GLY77U, GLY78U, GLY86U, HIS365V, ILE336V, ILE79U, LEU-21V, LEU-22V, LEU-29V, LEU-36V, LEU358V, LEU363V, LEU369V, LEU56U, LYS368V, MET386V, PHE-30V, PHE-33V, PHE222U, PHE355V, PHE81U, PRO-20V, PRO373V, SER-34V, SER-35V, SER54U, THR337V, THR84U, TYR359V, TYR366V, TYR57U, TYR87U, TYR89U, VAL353V, VAL361V, VAL60U, VAL94U
• U-1: ALA100U, ALA104U, ALA1151, ALA121, ALA12U, ALA148U, ALA201, ARG135U, ARG140U, ARG141, ARG14U, ARG161, ARG16U, ARG211, ARG261, ARG481, ARG751, ARG761, ARG85U, ARG97U, ASN101U, ASN691, ASN731, ASP144U, ASP149U, ASP721, GLN105U, GLN111, GLN1141, GLN114U, GLN11U, GLN511, GLN98U, GLU101, GLU10U, GLU1131, GLU113U, GLU1191, GLU126U, GLU137U, GLU150U, GLU151, GLU15U, GLU181, GLU701, GLY108U, GLY145U, GLY771, ILE1101, ILE141U, ILE147U, ILE71, ILE7U, LEU107U, LEU138U, LEU191, LEU501, LEU741, LYS1161, LYS134U, LYS221, LYS671, MET131, MET13U, PHE1111, PHE111U, PHE61, PHE681, PHE6U, PHE711, PHE81U, PRO1171, PRO136U, PRO151U, PRO461, PRO91, PRO9U, SER146U, SER171, SER471, SER491, SER81, SER8U, THR106U, THR109U, THR1121, THR112U, THR142U, THR95U, TYR103U, TYR1181, TYR139U, TYR143U, TYR51, TYR5U, VAL102U
• U-2: ALA3772, ALA3842, ALA4112, ALA82U, ALA88U, ARG3822, ARG3882, ARG85U, ARG91U, ARG92U, ARG97U, ASN101U, ASN3812, ASP-312, ASP-372, ASP83U, ASP90U, ASP93U, GLN105U, GLN80U, GLN98U, GLU132U, GLU3622, GLU3702, GLY3712, GLY3782, GLY77U, GLY86U, HIS129U, HIS3652, HIS4102, ILE3802, ILE3852, LEU-362, LEU3632, LEU3692, LEU3742, LEU3832, LYS3792, PHE-332, PHE3762, PHE81U, PRO3732, SER-342, SER-352, SER4122, THR-322, THR3752, THR84U, THR95U, TYR3662, TYR87U, TYR89U, VAL-382, VAL102U, VAL3722, VAL94U
• V-2: ALA-19V, ALA-25V, ALA349V, ALA350V, ALA3772, ALA3842, ALA393V, ALA3942, ALA4252, ALA4262, ARG-272, ARG-27V, ARG-282, ARG318V, ARG329V, ARG332V, ARG357V, ARG3822, ARG3882, ARG488V, ASN3812, ASN4302, ASP-312, ASP-372, ASP330V, ASP4242, GLN-26V, GLN-5V, GLN322V, GLN396V, GLN4372, GLU-23V, GLU354V, GLU4322, GLU4332, GLU4342, GLY328V, GLY3782, GLY3892, GLY397V, GLY4272, GLY4282, HIS-2V, ILE326V, ILE3852, ILE4312, ILE490V, LEU-212, LEU-21V, LEU-22V, LEU-29V, LEU-362, LEU-4V, LEU358V, LEU3912, LEU398V, LEU3992, LEU4012, LEU4442, LYS4472, LYS4512, MET325V, MET3952, PHE-30V, PHE-33V, PHE355V, PHE4232, PRO-20V, PRO-24V, PRO-3V, SER-342, SER320V, SER327V, SER4222, THR-322, THR348V, TRP4292, TYR335V, TYR4362, VAL-382, VAL331V, VAL351V, VAL353V
• W-X: ALA-25X, ALA356X, ALA360X, ALA82W, ALA88W, ARG-27X, ARG217W, ARG219W, ARG220W, ARG224W, ARG357X, ARG75W, ARG76W, ARG85W, ARG91W, ARG92W, ASP-31X, ASP-37X, ASP338X, ASP339X, ASP58W, ASP72W, ASP83W, ASP90W, ASP93W, GLN-26X, GLN51W, GLN80W, GLU-23X, GLU354X, GLU362X, GLU364X, GLU367X, GLU370X, GLU55W, GLY371X, GLY77W, GLY78W, GLY86W, HIS365X, ILE79W, LEU-21X, LEU-22X, LEU-29X, LEU-36X, LEU358X, LEU363X, LEU369X, LEU56W, LYS368X, PHE-30X, PHE-33X, PHE222W, PHE355X, PHE81W, PRO-20X, PRO373X, SER-34X, SER-35X, SER54W, THR-32X, THR337X, THR84W, TYR359X, TYR366X, TYR57W, TYR87W, TYR89W, VAL353X, VAL361X, VAL60W, VAL94W
• W-Y: ALA100Y, ALA104Y, ALA115W, ALA12W, ALA148Y, ARG135Y, ARG140Y, ARG14Y, ARG16W, ARG16Y, ARG224W, ARG26W, ARG48W, ARG75W, ARG76W, ARG85Y, ARG97Y, ASN101Y, ASN69W, ASN73W, ASP144Y, ASP149Y, ASP72W, GLN105Y, GLN114W, GLN114Y, GLN11W, GLN11Y, GLN51W, GLN98Y, GLU10Y, GLU113W, GLU113Y, GLU119W, GLU137Y, GLU15W, GLU18W, GLU70W, GLY108Y, GLY145Y, GLY77W, ILE110W, ILE141Y, ILE147Y, ILE7W, LEU107Y, LEU138Y, LEU19W, LEU50W, LEU74W, LYS116W, LYS22W, LYS67W, MET13Y, PHE111Y, PHE68W, PHE71W, PHE81Y, PRO117W, PRO151Y, PRO46W, PRO9Y, SER146Y, SER47W, SER49W, SER54W, SER8Y, THR106Y, THR109Y, THR112Y, THR142Y, TYR103Y, TYR118W, TYR139Y, TYR143Y, VAL102Y
• X-Y: ALA377X, ALA384X, ALA82Y, ALA88Y, ARG382X, ARG388X, ARG85Y, ARG91Y, ARG92Y, ARG97Y, ASN101Y, ASN381X, ASP-31X, ASP-37X, ASP83Y, ASP90Y, ASP93Y, GLN105Y, GLN80Y, GLN98Y, GLU132Y, GLU362X, GLU370X, GLY371X, GLY378X, GLY77Y, GLY86Y, HIS129Y, HIS365X, HIS410X, ILE380X, ILE385X, LEU-36X, LEU363X, LEU369X, LEU374X, LEU383X, LYS379X, PHE-33X, PHE376X, PHE81Y, PRO373X, SER-34X, SER-35X, SER412X, THR-32X, THR375X, THR84Y, THR95Y, TYR366X, TYR87Y, TYR89Y, VAL-38X, VAL102Y, VAL372X, VAL94Y
• X-Z: ALA-19Z, ALA-25Z, ALA349Z, ALA350Z, ALA377X, ALA384X, ALA393Z, ALA425X, ALA426X, ARG-27X, ARG-27Z, ARG-28X, ARG318Z, ARG329Z, ARG332Z, ARG357Z, ARG382X, ARG388X, ARG488Z, ASN381X, ASN390X, ASN430X, ASP-31X, ASP-37X, ASP330Z, ASP424X, GLN-26Z, GLN322Z, GLN396Z, GLN437X, GLU-23Z, GLU354Z, GLU432X, GLU433X, GLU434X, GLY328Z, GLY378X, GLY389X, GLY397Z, GLY427X, GLY428X, ILE326Z, ILE385X, ILE431X, ILE490Z, LEU-21Z, LEU-22Z, LEU-29Z, LEU-36X, LEU358Z, LEU391X, LEU398Z, LEU401X, LEU444X, LYS447X, LYS451X, MET325Z, MET386X, MET395X, PHE-30Z, PHE-33Z, PHE355Z, PHE423X, PRO-20Z, PRO-24Z, PRO-3Z, SER-34X, SER320Z, SER327Z, SER422X, THR-32X, THR348Z, THR375X, TRP429X, TYR335Z, TYR436X, VAL-38X, VAL331Z, VAL351Z, VAL353Z
• X-2: ALA3012, ALA301X, ALA4742, ALA474X, ALA4752, ALA475X, ALA4802, ALA480X, ARG3192, ARG319X, ARG3292, ARG329X, ARG4882, ARG488X, ARG5212, ARG521X, ASN3242, ASN324X, ASP4732, ASP473X, ASP4762, ASP476X, ASP4772, ASP477X, ASP4782, ASP478X, ASP4852, ASP485X, GLN-5X, GLN3222, GLN322X, GLU5192, GLU519X, GLY-12, GLY-1X, GLY3232, GLY323X, GLY4422, GLY442X, GLY482X, GLY489X, HIS-22, HIS-2X, ILE3262, ILE326X, ILE5172, ILE517X, ILE5182, ILE518X, LEU4442, LEU444X, LEU4862, LEU486X, MET3252, MET325X, PHE4452, PHE445X, PRO4842, SER3202, SER320X, SER3272, SER327X, SER4412, SER441X, SER4792, SER479X, SER5202, SER520X, SER5222, SER522X, THR3212, THR321X, THR4812, THR481X, TYR4722, TYR472X, VAL4872, VAL487X
• Y-Z: ALA-19Z, ALA-25Z, ALA356Z, ALA360Z, ALA82Y, ALA88Y, ARG-27Z, ARG219Y, ARG220Y, ARG224Y, ARG357Z, ARG75Y, ARG76Y, ARG85Y, ARG91Y, ARG92Y, ASN73Y, ASP-31Z, ASP-37Z, ASP338Z, ASP339Z, ASP58Y, ASP72Y, ASP83Y, ASP90Y, ASP93Y, GLN-26Z, GLN51Y, GLN80Y, GLU-23Z, GLU354Z, GLU362Z, GLU364Z, GLU367Z, GLU370Z, GLU55Y, GLY371Z, GLY77Y, GLY78Y, GLY86Y, HIS365Z, ILE79Y, LEU-21Z, LEU-22Z, LEU-29Z, LEU-36Z, LEU358Z, LEU363Z, LEU369Z, LEU56Y, LYS368Z, MET386Z, PHE-30Z, PHE-33Z, PHE222Y, PHE355Z, PHE81Y, PRO-20Z, PRO373Z, SER-34Z, SER-35Z, SER54Y, THR-32Z, THR337Z, THR84Y, TYR359Z, TYR366Z, TYR57Y, TYR87Y, TYR89Y, VAL353Z, VAL361Z, VAL60Y, VAL94Y
• 1-2: ALA-252, ALA3562, ALA3602, ALA821, ALA881, ARG-272, ARG2191, ARG2201, ARG2241, ARG3572, ARG751, ARG761, ARG851, ARG911, ARG921, ASN731, ASP-312, ASP-372, ASP3382, ASP3392, ASP581, ASP721, ASP831, ASP901, GLN-262, GLN511, GLN801, GLU-232, GLU3542, GLU3622, GLU3642, GLU3672, GLU3702, GLU551, GLY3712, GLY771, GLY781, GLY861, HIS3652, ILE791, LEU-212, LEU-222, LEU-292, LEU-362, LEU3582, LEU3632, LEU3692, LEU561, LYS3682, MET3862, PHE-302, PHE-332, PHE2221, PHE3552, PHE811, PRO-202, PRO-242, PRO3732, SER-342, SER-352, SER541, THR-322, THR3372, THR841, TYR3592, TYR3662, TYR571, TYR871, TYR891, VAL3532, VAL3612, VAL601, VAL941