3MFM

crystal structures and mutational analyses of acyl-coa carboxylase subunit of streptomyces coelicolor

• Total interactions analyzed: 15
• Total true interactions: 15
• Strongest Interaction:
  • Chains: A-B
  • Int. Res.: 406
  • Norm. En. per Res.: -4.304
• Hub Node: C(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
C-F	-213.2128	-222.7202	-1314.37	-1750.303	410	80	61	56979	16	109	120
C-A	-28.4504	-64.7075	-334.984	-428.1419	138	14	6	14142	7	51	50
C-B	0.0	5.8202	-5.6863	0.1339	20	2	0	490	0	9	12
C-D	-87.4568	-71.0573	-338.345	-496.8591	141	20	6	14518	9	51	49
C-E	0.0	0.0	-5.7116	-5.7116	15	0	0	542	0	0	3
F-A	0.0	0.0	-6.4807	-6.4807	12	0	0	580	0	1	3
F-B	-66.5013	-53.1689	-337.9	-457.5702	138	26	5	14918	6	51	49
F-D	0.0	8.1771	-4.3342	3.8429	16	2	0	461	0	11	12
F-E	-56.9107	-67.3049	-327.071	-451.2866	140	20	6	14494	6	52	48
A-B	-184.7439	-239.7252	-1322.96	-1747.4292	406	108	62	57103	20	109	121
A-D	-56.1512	-52.7729	-330.461	-439.3851	139	38	6	14741	1	49	48
A-E	-6.3379	-29.9205	-14.1977	-50.4561	22	1	0	757	4	12	12
B-D	0.0	0.0	-7.7439	-7.7439	13	0	0	492	0	0	2
B-E	-55.3808	-52.761	-324.6	-432.7419	137	39	6	15016	5	48	46
D-E	-180.9249	-200.9927	-1292.21	-1674.1276	410	69	60	56519	18	108	119

Interface residues

• C-F: ALA144C, ALA144F, ALA151C, ALA151F, ALA155C, ALA155F, ALA166C, ALA166F, ALA181F, ALA184C, ALA184F, ALA189C, ALA189F, ALA237C, ALA237F, ALA319C, ALA352C, ALA352F, ALA356C, ALA356F, ALA357C, ALA357F, ALA365C, ALA365F, ALA395C, ALA395F, ALA400C, ALA400F, ALA402C, ALA402F, ALA404C, ALA404F, ALA416C, ALA416F, ALA420C, ALA420F, ALA431C, ALA431F, ALA443C, ALA443F, ALA450C, ALA450F, ALA480F, ALA487C, ALA487F, ALA488C, ALA488F, ARG145C, ARG145F, ARG161C, ARG161F, ARG162C, ARG162F, ARG358C, ARG358F, ARG361C, ARG361F, ARG392C, ARG392F, ARG393C, ARG393F, ARG456C, ARG456F, ARG490C, ARG490F, ARG517C, ARG517F, ARG71C, ARG71F, ASN163C, ASN163F, ASN261C, ASN262C, ASN262F, ASN367C, ASN367F, ASN422C, ASN422F, ASN452C, ASN452F, ASN483C, ASN483F, ASN527C, ASN527F, ASN74C, ASN74F, ASP192C, ASP192F, ASP209C, ASP209F, ASP218C, ASP218F, ASP349C, ASP349F, ASP364C, ASP364F, ASP384C, ASP384F, ASP388C, ASP388F, CYS180C, CYS180F, CYS363C, CYS363F, GLN119C, GLN119F, GLN147C, GLN147F, GLN172C, GLN172F, GLN315C, GLN315F, GLN385C, GLN385F, GLN441C, GLN441F, GLN448C, GLN448F, GLU115C, GLU115F, GLU148C, GLU148F, GLU158C, GLU158F, GLU217C, GLU217F, GLU222C, GLU222F, GLU223C, GLU223F, GLU354C, GLU354F, GLU386C, GLU386F, GLU403C, GLU403F, GLU489C, GLU489F, GLU518C, GLU518F, GLY143C, GLY143F, GLY149C, GLY149F, GLY154C, GLY154F, GLY157C, GLY157F, GLY168C, GLY168F, GLY182C, GLY182F, GLY183C, GLY183F, GLY207C, GLY207F, GLY216C, GLY216F, GLY220C, GLY220F, GLY225C, GLY225F, GLY226C, GLY226F, GLY235C, GLY235F, GLY378C, GLY378F, GLY382C, GLY382F, GLY389C, GLY389F, GLY394C, GLY394F, GLY418C, GLY418F, GLY419C, GLY419F, GLY430C, GLY430F, GLY446C, GLY446F, GLY449C, GLY449F, GLY526C, GLY526F, GLY76F, HIS165C, HIS165F, HIS202C, HIS202F, HIS230C, HIS230F, HIS238C, HIS238F, HIS387C, HIS387F, HIS428C, HIS428F, HIS455C, HIS455F, HIS525C, HIS525F, ILE146C, ILE146F, ILE159C, ILE159F, ILE170C, ILE170F, ILE190C, ILE190F, ILE205C, ILE205F, ILE211C, ILE211F, ILE350C, ILE350F, ILE390C, ILE390F, ILE391C, ILE391F, ILE398C, ILE398F, ILE442C, ILE442F, ILE453C, ILE453F, ILE528C, ILE528F, LEU113C, LEU113F, LEU129C, LEU129F, LEU153C, LEU153F, LEU224C, LEU224F, LEU263C, LEU263F, LEU348C, LEU348F, LEU380C, LEU380F, LEU397C, LEU397F, LEU429C, LEU429F, LEU454C, LEU454F, LEU473C, LEU481C, LEU481F, LEU482C, LEU482F, LEU520C, LEU520F, LEU530C, LEU530F, LEU77F, LYS130C, LYS130F, LYS212C, LYS212F, LYS355C, LYS355F, LYS396C, LYS396F, LYS427C, LYS427F, LYS516C, LYS516F, LYS523C, LYS523F, LYS524C, LYS524F, MET196C, MET196F, MET203C, MET203F, MET445C, MET445F, PHE160C, PHE160F, PHE193C, PHE193F, PHE204C, PHE204F, PHE221F, PHE318C, PHE318F, PHE359C, PHE359F, PHE366C, PHE366F, PHE379C, PHE379F, PHE399C, PHE399F, PHE417C, PHE417F, PHE75C, PHE75F, PRO171C, PRO171F, PRO188C, PRO188F, PRO208C, PRO208F, PRO381C, PRO381F, PRO407C, PRO407F, PRO484C, PRO484F, PRO521C, PRO521F, PRO522C, PRO522F, PRO529C, PRO529F, SER152C, SER152F, SER167C, SER167F, SER187C, SER187F, SER232C, SER234C, SER234F, SER353C, SER353F, SER426C, SER426F, SER519C, SER519F, SER72C, SER72F, THR164C, THR164F, THR191C, THR191F, THR194C, THR194F, THR206C, THR206F, THR213C, THR213F, THR215C, THR215F, THR229C, THR229F, THR233C, THR233F, THR351C, THR351F, THR362C, THR362F, THR405C, THR405F, THR486C, THR486F, THR73C, THR73F, TYR156C, TYR156F, TYR186C, TYR186F, TYR401C, TYR401F, TYR421C, TYR421F, TYR477C, TYR477F, TYR485C, TYR485F, TYR492C, TYR492F, VAL116F, VAL150C, VAL150F, VAL169C, VAL169F, VAL176C, VAL176F, VAL185C, VAL185F, VAL210C, VAL210F, VAL214C, VAL214F, VAL219C, VAL219F, VAL236C, VAL236F, VAL360C, VAL360F, VAL368C, VAL368F, VAL383C, VAL383F, VAL406C, VAL406F, VAL423C, VAL423F, VAL444C, VAL444F, VAL451C, VAL451F, VAL493C, VAL493F
• C-A: ALA100C, ALA128C, ALA15C, ALA166C, ALA19C, ALA282A, ALA292A, ALA431A, ALA436A, ALA440A, ALA480A, ALA487A, ALA488A, ALA495A, ALA68C, ARG22C, ARG23C, ARG24C, ARG414A, ARG472A, ARG490A, ARG504A, ARG508A, ARG511A, ARG514A, ARG517A, ARG69C, ARG71C, ARG81C, ARG97C, ASN261C, ASN262C, ASN434A, ASN483A, ASP20C, ASP285A, ASP290A, ASP432A, ASP479A, ASP494A, ASP501A, ASP57C, ASP65C, ASP85C, CYS133C, GLN119C, GLN441A, GLN475A, GLN512A, GLU115C, GLU476A, GLU478A, GLU489A, GLU518A, GLU58C, GLU63C, GLU66C, GLY132C, GLY16C, GLY430A, GLY491A, GLY509A, GLY59C, GLY84C, GLY90C, GLY92C, GLY96C, HIS12C, HIS505A, HIS70C, ILE11C, ILE170C, ILE25C, ILE287A, ILE409A, ILE497A, ILE506A, LEU129C, LEU18C, LEU21C, LEU263C, LEU275A, LEU284A, LEU408A, LEU433A, LEU435A, LEU482A, LEU510A, LEU513A, LEU64C, LYS120C, LYS123C, LYS130C, LYS17C, LYS427A, LYS516A, MET498A, PHE127C, PHE61C, PHE67C, PRO134C, PRO289A, PRO407A, PRO438A, PRO484A, PRO499A, PRO98C, SER260C, SER264C, SER291A, SER500A, SER519A, SER60C, THR131C, THR13C, THR14C, THR286A, THR405A, THR439A, THR486A, THR515A, THR93C, TRP437A, TYR485A, TYR492A, TYR83C, TYR91C, VAL101C, VAL116C, VAL169C, VAL288A, VAL406A, VAL493A, VAL496A, VAL507A, VAL62C, VAL94C, VAL99C
• C-B: ALA151B, ALA151C, ARG161B, ARG71B, ARG71C, ARG81B, ARG81C, ASN74B, ASN74C, ASP78B, ASP78C, GLN119B, GLN119C, GLU115B, GLU115C, LYS130C, SER72B, SER72C, THR73B, THR73C
• C-D: ALA100D, ALA128D, ALA15D, ALA166D, ALA19D, ALA282C, ALA292C, ALA431C, ALA436C, ALA440C, ALA480C, ALA487C, ALA488C, ALA495C, ALA68D, ARG22D, ARG23D, ARG24D, ARG414C, ARG472C, ARG490C, ARG504C, ARG508C, ARG511C, ARG514C, ARG517C, ARG69D, ARG71D, ARG81D, ARG97D, ASN261D, ASN262D, ASN434C, ASN483C, ASP10D, ASP126D, ASP20D, ASP285C, ASP290C, ASP432C, ASP479C, ASP494C, ASP501C, ASP57D, ASP65D, ASP85D, CYS133D, GLN119D, GLN441C, GLN475C, GLN512C, GLU115D, GLU476C, GLU478C, GLU489C, GLU518C, GLU58D, GLU63D, GLU66D, GLY132D, GLY168D, GLY16D, GLY430C, GLY491C, GLY509C, GLY59D, GLY84D, GLY90D, GLY92D, GLY96D, HIS12D, HIS505C, HIS70D, ILE11D, ILE170D, ILE25D, ILE287C, ILE409C, ILE474C, ILE497C, ILE506C, LEU129D, LEU18D, LEU21D, LEU263D, LEU275C, LEU284C, LEU408C, LEU433C, LEU435C, LEU482C, LEU510C, LEU513C, LEU56D, LEU64D, LYS120D, LYS123D, LYS130D, LYS17D, LYS427C, LYS516C, MET498C, PHE127D, PHE61D, PHE67D, PRO289C, PRO407C, PRO438C, PRO484C, PRO499C, PRO98D, SER260D, SER291C, SER500C, SER519C, SER60D, THR131D, THR13D, THR14D, THR286C, THR405C, THR413C, THR439C, THR486C, THR515C, THR93D, TRP437C, TYR485C, TYR492C, TYR83D, TYR91D, VAL116D, VAL169D, VAL288C, VAL406C, VAL493C, VAL496C, VAL507C, VAL62D, VAL94D, VAL99D
• C-E: ARG490C, ARG490E, ARG517C, ARG517E, GLU518C, GLU518E, LEU520C, LEU520E, LYS523E, PRO521C, PRO521E, PRO522C, PRO522E, SER519C, SER519E
• F-A: ARG517A, ARG517F, GLU518F, LEU520A, LEU520F, LYS523A, PRO521A, PRO521F, PRO522A, PRO522F, SER519A, SER519F
• F-B: ALA100B, ALA128B, ALA15B, ALA166B, ALA19B, ALA282F, ALA431F, ALA436F, ALA440F, ALA480F, ALA487F, ALA488F, ALA495F, ALA68B, ARG22B, ARG23B, ARG24B, ARG414F, ARG490F, ARG504F, ARG508F, ARG511F, ARG514F, ARG517F, ARG69B, ARG71B, ARG81B, ARG97B, ASN261B, ASN262B, ASN434F, ASN483F, ASP10B, ASP126B, ASP20B, ASP285F, ASP290F, ASP432F, ASP479F, ASP494F, ASP501F, ASP57B, ASP65B, ASP85B, CYS133B, GLN119B, GLN294F, GLN441F, GLN475F, GLN512F, GLU115B, GLU476F, GLU478F, GLU489F, GLU518F, GLU58B, GLU63B, GLU66B, GLY132B, GLY16B, GLY430F, GLY491F, GLY509F, GLY59B, GLY84B, GLY90B, GLY92B, GLY96B, HIS12B, HIS505F, HIS70B, ILE11B, ILE170B, ILE25B, ILE287F, ILE409F, ILE497F, ILE506F, LEU129B, LEU18B, LEU21B, LEU263B, LEU275F, LEU284F, LEU408F, LEU433F, LEU435F, LEU482F, LEU510F, LEU513F, LEU64B, LYS120B, LYS123B, LYS130B, LYS17B, LYS427F, LYS516F, MET498F, PHE127B, PHE61B, PHE67B, PRO134B, PRO289F, PRO407F, PRO438F, PRO484F, PRO499F, PRO98B, SER260B, SER264B, SER291F, SER500F, SER519F, SER60B, THR131B, THR13B, THR14B, THR286F, THR405F, THR439F, THR486F, THR515F, THR93B, TRP437F, TYR485F, TYR492F, TYR83B, TYR91B, VAL116B, VAL169B, VAL288F, VAL406F, VAL493F, VAL496F, VAL507F, VAL62B, VAL94B, VAL99B
• F-D: ALA151D, ALA151F, ARG71D, ARG71F, ARG81D, ASN74D, ASP78D, ASP78F, GLN119D, GLN119F, GLU115D, GLU115F, SER72D, SER72F, THR73D, THR73F
• F-E: ALA100F, ALA128F, ALA15F, ALA166F, ALA19F, ALA282E, ALA292E, ALA431E, ALA436E, ALA440E, ALA480E, ALA487E, ALA488E, ALA495E, ALA68F, ARG22F, ARG23F, ARG24F, ARG414E, ARG490E, ARG504E, ARG508E, ARG511E, ARG514E, ARG517E, ARG69F, ARG71F, ARG81F, ARG97F, ASN261F, ASN262F, ASN434E, ASN483E, ASP10F, ASP126F, ASP20F, ASP285E, ASP290E, ASP432E, ASP479E, ASP494E, ASP501E, ASP57F, ASP65F, ASP85F, CYS133F, GLN119F, GLN441E, GLN475E, GLN512E, GLU115F, GLU283E, GLU476E, GLU478E, GLU489E, GLU518E, GLU58F, GLU63F, GLU66F, GLY132F, GLY16F, GLY430E, GLY491E, GLY509E, GLY59F, GLY84F, GLY90F, GLY92F, GLY96F, HIS12F, HIS505E, HIS70F, ILE11F, ILE170F, ILE25F, ILE287E, ILE409E, ILE497E, ILE506E, LEU129F, LEU18F, LEU21F, LEU263F, LEU275E, LEU284E, LEU408E, LEU433E, LEU435E, LEU482E, LEU510E, LEU513E, LEU56F, LEU64F, LYS120F, LYS123F, LYS130F, LYS17F, LYS427E, LYS516E, MET498E, PHE127F, PHE61F, PHE67F, PRO134F, PRO289E, PRO407E, PRO438E, PRO484E, PRO499E, PRO98F, SER260F, SER264F, SER291E, SER500E, SER60F, THR131F, THR13F, THR14F, THR286E, THR405E, THR439E, THR486E, THR515E, THR93F, TRP437E, TYR485E, TYR492E, TYR83F, TYR91F, VAL101F, VAL116F, VAL169F, VAL288E, VAL406E, VAL493E, VAL496E, VAL507E, VAL62F, VAL94F, VAL99F
• A-B: ALA144A, ALA144B, ALA151A, ALA151B, ALA155A, ALA155B, ALA166A, ALA166B, ALA181A, ALA181B, ALA184A, ALA184B, ALA189A, ALA189B, ALA237A, ALA237B, ALA319B, ALA352B, ALA356A, ALA356B, ALA357A, ALA357B, ALA365A, ALA365B, ALA395A, ALA395B, ALA400A, ALA400B, ALA402A, ALA402B, ALA404A, ALA404B, ALA416A, ALA416B, ALA420A, ALA420B, ALA431A, ALA431B, ALA443A, ALA443B, ALA450A, ALA450B, ALA480B, ALA487A, ALA487B, ALA488A, ALA488B, ARG145A, ARG145B, ARG161A, ARG161B, ARG162A, ARG162B, ARG358A, ARG358B, ARG361A, ARG361B, ARG392A, ARG392B, ARG393A, ARG393B, ARG490A, ARG490B, ARG517A, ARG71A, ARG71B, ASN163A, ASN163B, ASN262A, ASN262B, ASN367A, ASN367B, ASN422A, ASN422B, ASN452A, ASN452B, ASN483A, ASN483B, ASN527A, ASN527B, ASN74A, ASN74B, ASP192A, ASP192B, ASP209A, ASP209B, ASP218A, ASP218B, ASP349A, ASP349B, ASP364A, ASP364B, ASP384A, ASP384B, ASP388A, ASP388B, CYS180A, CYS180B, CYS347B, CYS363A, CYS363B, GLN119A, GLN119B, GLN147A, GLN147B, GLN172A, GLN172B, GLN315A, GLN315B, GLN385A, GLN385B, GLN441A, GLN441B, GLN448A, GLN448B, GLU115A, GLU115B, GLU148A, GLU148B, GLU158A, GLU158B, GLU217A, GLU217B, GLU222A, GLU222B, GLU223A, GLU223B, GLU354A, GLU354B, GLU386A, GLU386B, GLU403A, GLU403B, GLU476B, GLU489A, GLU489B, GLU518A, GLU518B, GLY143B, GLY149A, GLY149B, GLY154A, GLY154B, GLY157A, GLY157B, GLY168A, GLY168B, GLY182A, GLY182B, GLY183A, GLY183B, GLY207A, GLY207B, GLY216A, GLY216B, GLY220A, GLY220B, GLY225A, GLY225B, GLY226A, GLY226B, GLY235A, GLY235B, GLY378A, GLY378B, GLY382A, GLY382B, GLY389A, GLY389B, GLY394A, GLY394B, GLY418A, GLY418B, GLY419A, GLY419B, GLY430A, GLY430B, GLY446A, GLY446B, GLY449A, GLY449B, GLY526A, GLY526B, HIS165A, HIS165B, HIS202A, HIS230A, HIS230B, HIS238A, HIS238B, HIS387A, HIS387B, HIS428A, HIS428B, HIS455A, HIS455B, HIS525A, HIS525B, HIS70A, ILE146A, ILE146B, ILE159A, ILE159B, ILE170A, ILE170B, ILE190A, ILE190B, ILE205A, ILE205B, ILE211A, ILE211B, ILE350A, ILE350B, ILE390A, ILE390B, ILE391A, ILE391B, ILE398A, ILE398B, ILE442A, ILE442B, ILE453A, ILE453B, ILE528A, ILE528B, LEU113A, LEU113B, LEU129A, LEU129B, LEU153A, LEU153B, LEU224A, LEU224B, LEU263A, LEU263B, LEU348A, LEU348B, LEU380A, LEU380B, LEU397A, LEU397B, LEU429A, LEU429B, LEU454A, LEU454B, LEU473B, LEU481A, LEU481B, LEU482B, LEU520A, LEU520B, LEU530A, LEU530B, LEU77A, LEU77B, LYS130A, LYS130B, LYS212A, LYS212B, LYS355A, LYS355B, LYS396A, LYS396B, LYS415A, LYS427A, LYS427B, LYS516A, LYS516B, LYS523A, LYS523B, LYS524A, LYS524B, MET196A, MET203A, MET203B, MET445A, MET445B, PHE160A, PHE160B, PHE193A, PHE193B, PHE204A, PHE204B, PHE221A, PHE221B, PHE318A, PHE318B, PHE359A, PHE359B, PHE366A, PHE366B, PHE379A, PHE379B, PHE399A, PHE399B, PHE417A, PHE417B, PHE75A, PHE75B, PRO171A, PRO171B, PRO188A, PRO188B, PRO208A, PRO208B, PRO381A, PRO381B, PRO407A, PRO407B, PRO484A, PRO484B, PRO521A, PRO521B, PRO522A, PRO522B, PRO529A, PRO529B, SER152A, SER152B, SER167A, SER167B, SER187A, SER187B, SER234A, SER234B, SER353A, SER353B, SER426A, SER426B, SER519A, SER519B, SER72A, SER72B, THR164A, THR164B, THR191A, THR191B, THR194A, THR194B, THR206A, THR206B, THR213A, THR213B, THR215A, THR215B, THR229A, THR229B, THR233A, THR233B, THR351A, THR351B, THR362A, THR362B, THR405A, THR405B, THR486A, THR486B, THR73A, THR73B, TYR156A, TYR156B, TYR186A, TYR186B, TYR401A, TYR401B, TYR421A, TYR421B, TYR477A, TYR477B, TYR485A, TYR485B, TYR492A, TYR492B, VAL116A, VAL116B, VAL150A, VAL150B, VAL169A, VAL169B, VAL176A, VAL185A, VAL185B, VAL210A, VAL210B, VAL214A, VAL214B, VAL219A, VAL219B, VAL236A, VAL236B, VAL360A, VAL360B, VAL368A, VAL368B, VAL383A, VAL383B, VAL406A, VAL406B, VAL423A, VAL423B, VAL444A, VAL444B, VAL451A, VAL451B, VAL493A, VAL493B
• A-D: ALA100A, ALA128A, ALA15A, ALA166A, ALA19A, ALA282D, ALA292D, ALA431D, ALA436D, ALA440D, ALA480D, ALA487D, ALA488D, ALA495D, ALA68A, ARG22A, ARG23A, ARG24A, ARG414D, ARG472D, ARG490D, ARG504D, ARG508D, ARG511D, ARG514D, ARG517D, ARG69A, ARG71A, ARG81A, ARG97A, ASN261A, ASN262A, ASN434D, ASN483D, ASP10A, ASP126A, ASP20A, ASP285D, ASP290D, ASP432D, ASP479D, ASP494D, ASP501D, ASP57A, ASP65A, ASP85A, CYS133A, GLN119A, GLN441D, GLN475D, GLN512D, GLU476D, GLU478D, GLU489D, GLU518D, GLU58A, GLU63A, GLU66A, GLY132A, GLY16A, GLY430D, GLY491D, GLY509D, GLY59A, GLY84A, GLY90A, GLY92A, GLY96A, HIS12A, HIS505D, HIS70A, ILE11A, ILE170A, ILE25A, ILE287D, ILE409D, ILE497D, ILE506D, LEU129A, LEU18A, LEU21A, LEU263A, LEU275D, LEU284D, LEU408D, LEU433D, LEU435D, LEU482D, LEU510D, LEU513D, LEU56A, LEU64A, LYS120A, LYS123A, LYS130A, LYS17A, LYS427D, LYS516D, MET498D, PHE127A, PHE61A, PHE67A, PRO134A, PRO289D, PRO407D, PRO438D, PRO484D, PRO499D, PRO98A, SER260A, SER264A, SER291D, SER500D, SER60A, THR131A, THR13A, THR14A, THR286D, THR405D, THR413D, THR439D, THR486D, THR515D, THR93A, TRP437D, TYR485D, TYR492D, TYR83A, TYR91A, VAL116A, VAL169A, VAL288D, VAL406D, VAL493D, VAL496D, VAL507D, VAL62A, VAL94A, VAL99A
• A-E: ALA151A, ALA151E, ARG71A, ARG71E, ARG81A, ASN74A, ASN74E, ASP78A, ASP78E, GLN119A, GLN119E, GLU115A, GLU115E, GLU148E, HIS70A, HIS70E, SER72A, SER72E, THR73A, THR73E, VAL116E, VAL150E
• B-D: ARG517B, ARG517D, GLU518B, GLU518D, LEU520B, LEU520D, LYS523D, PRO521B, PRO521D, PRO522B, PRO522D, SER519B, SER519D
• B-E: ALA100E, ALA128E, ALA15E, ALA166E, ALA19E, ALA282B, ALA292B, ALA431B, ALA436B, ALA440B, ALA480B, ALA487B, ALA488B, ALA495B, ALA68E, ARG22E, ARG23E, ARG24E, ARG414B, ARG490B, ARG504B, ARG508B, ARG511B, ARG514B, ARG517B, ARG69E, ARG71E, ARG81E, ARG97E, ASN261E, ASN262E, ASN434B, ASN483B, ASP10E, ASP20E, ASP285B, ASP290B, ASP432B, ASP479B, ASP494B, ASP501B, ASP57E, ASP65E, ASP85E, CYS133E, GLN119E, GLN441B, GLN475B, GLN512B, GLU115E, GLU283B, GLU476B, GLU478B, GLU489B, GLU518B, GLU58E, GLU63E, GLU66E, GLY132E, GLY168E, GLY16E, GLY430B, GLY491B, GLY509B, GLY59E, GLY90E, GLY92E, GLY96E, HIS12E, HIS505B, HIS70E, ILE11E, ILE170E, ILE25E, ILE287B, ILE409B, ILE497B, ILE506B, LEU129E, LEU18E, LEU21E, LEU263E, LEU275B, LEU284B, LEU408B, LEU433B, LEU435B, LEU482B, LEU510B, LEU513B, LEU64E, LYS120E, LYS123E, LYS130E, LYS17E, LYS427B, LYS516B, MET498B, PHE127E, PHE61E, PHE67E, PRO134E, PRO289B, PRO407B, PRO438B, PRO484B, PRO499B, PRO98E, SER260E, SER291B, SER500B, SER519B, SER60E, THR131E, THR13E, THR14E, THR286B, THR405B, THR413B, THR439B, THR486B, THR515B, THR93E, TRP437B, TYR485B, TYR492B, TYR83E, TYR91E, VAL116E, VAL169E, VAL288B, VAL406B, VAL493B, VAL496B, VAL507B, VAL62E, VAL99E
• D-E: ALA144D, ALA144E, ALA151D, ALA151E, ALA155D, ALA155E, ALA166D, ALA166E, ALA181D, ALA181E, ALA184D, ALA184E, ALA189D, ALA189E, ALA237D, ALA237E, ALA319D, ALA352D, ALA356D, ALA356E, ALA357D, ALA357E, ALA365D, ALA365E, ALA395D, ALA395E, ALA400D, ALA400E, ALA402D, ALA402E, ALA404D, ALA404E, ALA416D, ALA416E, ALA420D, ALA420E, ALA431D, ALA431E, ALA443D, ALA443E, ALA450D, ALA450E, ALA480D, ALA487D, ALA487E, ALA488D, ALA488E, ARG145D, ARG145E, ARG161D, ARG161E, ARG162D, ARG162E, ARG358D, ARG358E, ARG361D, ARG361E, ARG392D, ARG392E, ARG393D, ARG393E, ARG470E, ARG490D, ARG490E, ARG517D, ARG517E, ARG71D, ARG71E, ASN163D, ASN163E, ASN261D, ASN261E, ASN262D, ASN262E, ASN367D, ASN367E, ASN422D, ASN422E, ASN452D, ASN452E, ASN483D, ASN483E, ASN527D, ASN527E, ASN74D, ASN74E, ASP192D, ASP192E, ASP209D, ASP209E, ASP218D, ASP218E, ASP349D, ASP349E, ASP364D, ASP364E, ASP384D, ASP384E, ASP388D, ASP388E, CYS180D, CYS180E, CYS347D, CYS363D, CYS363E, GLN119D, GLN147D, GLN147E, GLN172D, GLN172E, GLN315D, GLN315E, GLN385D, GLN385E, GLN441D, GLN441E, GLN448D, GLN448E, GLU115D, GLU115E, GLU148D, GLU148E, GLU158D, GLU158E, GLU217D, GLU217E, GLU222D, GLU222E, GLU223D, GLU223E, GLU354D, GLU354E, GLU386D, GLU386E, GLU403D, GLU403E, GLU489D, GLU489E, GLU518D, GLU518E, GLY143E, GLY149D, GLY149E, GLY154D, GLY154E, GLY157D, GLY157E, GLY168D, GLY168E, GLY182D, GLY182E, GLY183D, GLY183E, GLY207D, GLY207E, GLY216D, GLY216E, GLY220D, GLY220E, GLY225D, GLY225E, GLY226D, GLY226E, GLY235D, GLY235E, GLY378D, GLY378E, GLY382D, GLY382E, GLY389D, GLY389E, GLY394D, GLY394E, GLY418D, GLY418E, GLY419D, GLY419E, GLY430D, GLY430E, GLY446D, GLY446E, GLY449D, GLY449E, GLY491E, GLY526D, GLY526E, GLY76D, GLY76E, HIS165D, HIS165E, HIS202D, HIS202E, HIS230D, HIS230E, HIS238D, HIS238E, HIS387D, HIS387E, HIS428D, HIS428E, HIS455D, HIS455E, HIS525D, HIS525E, ILE146D, ILE146E, ILE159D, ILE159E, ILE170D, ILE170E, ILE190D, ILE190E, ILE205D, ILE205E, ILE211D, ILE211E, ILE350D, ILE350E, ILE390D, ILE390E, ILE391D, ILE391E, ILE398D, ILE398E, ILE442D, ILE442E, ILE453D, ILE453E, ILE528D, ILE528E, LEU113D, LEU129D, LEU129E, LEU153D, LEU153E, LEU224D, LEU224E, LEU263D, LEU263E, LEU348D, LEU348E, LEU380D, LEU380E, LEU397D, LEU397E, LEU429D, LEU429E, LEU454D, LEU454E, LEU473D, LEU473E, LEU481D, LEU481E, LEU482D, LEU482E, LEU520D, LEU520E, LEU530D, LEU530E, LEU77D, LEU77E, LYS130D, LYS130E, LYS212D, LYS212E, LYS355D, LYS355E, LYS396D, LYS396E, LYS427D, LYS427E, LYS516D, LYS516E, LYS523D, LYS523E, LYS524D, LYS524E, MET196D, MET196E, MET203D, MET203E, MET445D, MET445E, PHE160D, PHE160E, PHE193D, PHE193E, PHE204D, PHE204E, PHE221D, PHE221E, PHE318D, PHE318E, PHE359D, PHE359E, PHE366D, PHE366E, PHE379D, PHE379E, PHE399D, PHE399E, PHE417D, PHE417E, PHE75D, PHE75E, PRO188D, PRO188E, PRO208D, PRO208E, PRO369E, PRO381D, PRO381E, PRO407D, PRO407E, PRO484D, PRO484E, PRO521D, PRO521E, PRO522D, PRO522E, PRO529D, PRO529E, SER152D, SER152E, SER167D, SER167E, SER187D, SER187E, SER234D, SER234E, SER353D, SER353E, SER426D, SER426E, SER519D, SER519E, SER72D, SER72E, THR164D, THR164E, THR191D, THR191E, THR194D, THR194E, THR206D, THR206E, THR213D, THR213E, THR215D, THR215E, THR229D, THR229E, THR233D, THR233E, THR351D, THR351E, THR362D, THR362E, THR405D, THR405E, THR486D, THR486E, THR73D, THR73E, TYR156D, TYR156E, TYR186D, TYR186E, TYR401D, TYR401E, TYR421D, TYR421E, TYR477D, TYR477E, TYR485D, TYR485E, TYR492D, TYR492E, VAL116D, VAL150D, VAL150E, VAL169D, VAL169E, VAL176D, VAL185D, VAL185E, VAL210D, VAL210E, VAL214D, VAL214E, VAL219D, VAL219E, VAL236D, VAL236E, VAL360D, VAL360E, VAL368D, VAL368E, VAL383D, VAL383E, VAL406D, VAL406E, VAL423D, VAL423E, VAL444D, VAL444E, VAL451D, VAL451E, VAL493D, VAL493E