3MB2

kinetic and structural characterization of a heterohexamer 4- oxalocrotonate tautomerase from chloroflexus aurantiacus j-10-fl: implications for functional and structural diversity in the tautomerase superfamily

• Total interactions analyzed: 66
• Total true interactions: 36
• Strongest Interaction:
  • Chains: A-D
  • Int. Res.: 90
  • Norm. En. per Res.: -5.4727
• Hub Node: A(7)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	0.0	0.0	-0.2746	-0.2746	4	0	0	39	0	2	0
A-C	-46.4136	-10.3433	-124.763	-181.5199	51	6	2	5549	1	8	10
A-D	-89.867	-98.3455	-304.331	-492.5435	90	14	19	12357	4	9	10
A-E	-46.8015	-8.5913	-113.22	-168.6128	52	7	1	5442	1	8	10
A-F	-5.2635	23.1667	-47.5156	-29.6125	24	2	0	1948	3	3	1
A-I	-7.9624	18.8534	-26.6882	-15.7972	15	12	0	1129	0	6	10
A-K	0.0	16.1904	-3.2064	12.984	21	0	0	447	0	7	6
B-C	-7.4966	19.8939	-56.6882	-44.2909	26	2	0	2002	4	3	1
B-D	-27.703	-31.1225	-132.139	-190.9645	55	8	8	5854	3	6	2
B-E	-100.2513	-83.3716	-290.566	-474.1889	92	11	18	12010	5	10	9
B-F	-32.2378	-46.5529	-99.7491	-178.5399	47	9	5	4554	4	3	2
C-D	0.0	0.0	-0.1982	-0.1982	7	0	0	32	0	2	0
C-E	-42.6227	-7.9277	-116.708	-167.2584	51	7	1	5543	1	8	10
C-F	-89.6756	-74.4023	-292.975	-457.0529	92	9	19	12141	5	9	9
C-G	0.0	16.7203	-36.0745	-19.3542	14	5	0	1050	0	6	9
C-I	0.0	15.2884	-3.1954	12.0931	18	0	0	437	0	6	5
D-E	-4.3956	11.5924	-39.4404	-32.2436	26	6	0	1747	3	3	1
D-F	-19.3517	0.0	-129.496	-148.8477	52	2	8	5795	0	5	2
E-F	0.0	0.0	-0.2068	-0.2068	6	0	0	38	0	2	0
E-G	0.0	16.5647	-2.8806	13.6841	18	0	0	409	0	6	6
E-K	-2.8719	18.0276	-30.0599	-14.9042	14	11	0	1087	0	6	9
G-H	0.0	0.0	-0.199	-0.199	5	0	0	31	0	2	0
G-I	-50.5594	-11.3054	-124.136	-186.0008	50	7	2	5528	1	8	10
G-J	-86.3804	-100.7252	-297.525	-484.6306	92	14	19	12408	6	10	8
G-K	-44.4661	-11.293	-114.009	-169.7681	51	7	1	5489	1	8	10
G-L	-3.702	26.9298	-42.7098	-19.482	24	4	0	1877	3	3	1
H-I	-7.3318	13.5863	-34.1675	-27.9129	27	12	0	2097	4	3	1
H-J	-41.3335	-42.764	-137.835	-221.9325	53	7	8	5922	3	5	2
H-K	-105.1081	-94.0671	-288.964	-488.1392	91	11	18	12059	5	9	9
H-L	-58.5406	-40.8725	-113.234	-212.6471	46	5	6	4507	2	3	2
I-J	0.0	0.0	-0.2077	-0.2077	8	0	0	38	0	2	0
I-K	-56.6148	-13.9667	-123.372	-193.9535	51	7	2	5548	1	8	10
I-L	-99.8138	-99.9695	-308.774	-508.5573	93	9	19	12482	7	10	9
J-K	-7.8093	12.8725	-40.9911	-35.9279	25	2	0	1854	4	3	1
J-L	-27.5374	-36.9972	-129.198	-193.7326	53	6	8	5878	2	6	2
K-L	0.0	0.0	-0.1931	-0.1931	6	0	0	32	0	2	0

Interface residues

• A-B: ARG5A, GLU4B, MET2B, PHE6B
• A-C: ALA18A, ALA21A, ALA23A, ALA26A, ALA29A, ALA37A, ARG22A, ARG40A, ARG5A, ARG5C, GLN44A, GLN44C, GLU10A, GLU19A, GLU38A, GLU45A, GLU45C, GLU60C, GLY54C, GLY55C, HIS50C, ILE42A, ILE43A, ILE56C, ILE6A, ILE6C, LEU20A, LEU24A, LEU2A, LEU36A, LEU3A, LEU41A, LEU4A, LEU9C, LYS17A, MET58C, MET8A, MET8C, PRO35A, PRO47C, SER25A, SER57C, THR14A, THR49C, THR52C, THR7A, THR7C, TRP51C, VAL39A, VAL46C, VAL53C
• A-D: ALA18A, ALA20D, ALA21A, ALA22D, ALA23A, ALA23D, ALA25D, ALA26A, ALA27A, ALA27D, ALA28A, ALA29A, ALA30A, ALA31A, ALA54D, ARG11D, ARG12A, ARG17D, ARG22A, ARG31D, ARG39D, ARG40A, ARG5A, ASN51D, ASP10D, ASP14D, ASP33A, GLN16A, GLN19D, GLN30D, GLN41D, GLN44A, GLN45D, GLU15A, GLU19A, GLU24D, GLU4D, GLY34D, GLY9D, ILE28D, ILE33D, ILE42A, ILE43A, ILE43D, ILE44D, ILE46D, ILE6A, LEU20A, LEU24A, LEU2A, LEU3A, LEU3D, LEU40D, LEU41A, LEU42D, LEU4A, LEU53D, LEU9A, LYS17A, LYS18D, MET1A, MET2D, MET58A, MET8A, PHE21D, PHE29D, PHE32A, PHE6D, PRO12D, PRO13D, PRO1D, PRO36D, PRO49D, SER13A, SER25A, SER26D, SER8D, THR16D, THR35D, THR52D, THR7A, TRP51A, TYR7D, VAL32D, VAL34A, VAL39A, VAL46A, VAL47D, VAL53A, VAL5D
• A-E: ALA18E, ALA21E, ALA23E, ALA26E, ALA29E, ALA37E, ARG12E, ARG22E, ARG40E, ARG5A, ARG5E, GLN44A, GLN44E, GLU10E, GLU19E, GLU38E, GLU45A, GLU45E, GLU60A, GLY54A, GLY55A, HIS50A, ILE42E, ILE43E, ILE56A, ILE6A, ILE6E, LEU20E, LEU24E, LEU36E, LEU3E, LEU41E, LEU4E, LEU9A, LYS17E, MET58A, MET8A, MET8E, PRO35E, PRO47A, SER13E, SER25E, SER57A, THR14E, THR49A, THR52A, THR7A, TRP51A, VAL39E, VAL46A, VAL46E, VAL53A
• A-F: ALA37A, ARG39F, ARG40A, ARG5A, GLN41F, GLU38A, GLU4F, GLY38F, ILE42A, ILE43F, ILE44F, LEU2A, LEU3A, LEU3F, LEU40F, LEU42F, LEU4A, MET1A, MET2F, PHE6F, PRO1F, PRO36F, THR35F, VAL39A
• A-I: ARG12A, ARG12I, GLN16A, GLN16I, GLU15A, GLU15I, GLU45I, GLY11A, GLY11I, LYS17A, LYS17I, SER13A, SER13I, THR14A, THR14I
• A-K: ALA59A, ALA59K, ARG12A, ARG12K, ARG62K, GLU10A, GLU10K, GLY11A, GLY11K, LEU61A, LEU61K, LYS17A, LYS17K, PRO47A, PRO47K, PRO48A, PRO48K, SER13A, SER13K, THR49A, THR49K
• B-C: ALA37C, ARG39B, ARG40C, ARG5C, GLN41B, GLN44C, GLU38C, GLU4B, GLY38B, ILE42C, ILE43B, ILE44B, LEU2C, LEU3B, LEU3C, LEU40B, LEU41C, LEU42B, LEU4C, MET1C, MET2B, PHE6B, PRO1B, PRO36B, THR35B, VAL39C
• B-D: ALA20D, ALA22D, ALA23D, ALA25D, ALA27D, ALA54B, ARG15D, ARG17D, ARG39D, ASN51B, ASP14D, ASP57B, ASP59B, GLN19D, GLN41D, GLN45B, GLN45D, GLU24D, GLU4B, GLU4D, GLU50B, GLY38D, ILE43B, ILE43D, ILE44D, ILE46B, ILE46D, ILE56B, LEU3D, LEU40D, LEU42D, LEU53B, LEU58B, LYS18D, MET2D, PHE21D, PHE29D, PHE6B, PHE6D, PRO13D, PRO36D, PRO37D, PRO49B, SER26D, SER48B, SER8B, THR16D, THR35D, THR52B, TYR7B, VAL47B, VAL47D, VAL55B, VAL5B, VAL5D
• B-E: ALA18E, ALA20B, ALA21E, ALA22B, ALA23E, ALA25B, ALA26E, ALA27B, ALA27E, ALA28E, ALA29E, ALA30E, ALA31E, ALA54B, ARG11B, ARG12E, ARG17B, ARG22E, ARG31B, ARG39B, ARG40E, ARG5E, ASN51B, ASP10B, ASP14B, ASP33E, GLN16E, GLN19B, GLN30B, GLN41B, GLN44E, GLN45B, GLU15E, GLU19E, GLU24B, GLU38E, GLU4B, GLY34B, GLY9B, ILE28B, ILE33B, ILE42E, ILE43B, ILE43E, ILE44B, ILE46B, ILE6E, LEU20E, LEU24E, LEU2E, LEU3B, LEU3E, LEU40B, LEU41E, LEU42B, LEU4E, LEU53B, LEU9E, LYS17E, LYS18B, MET1E, MET2B, MET58E, MET8E, PHE21B, PHE29B, PHE32E, PHE6B, PRO12B, PRO13B, PRO1B, PRO35E, PRO36B, PRO49B, SER13E, SER25E, SER26B, SER48B, SER8B, THR16B, THR35B, THR52B, THR7E, TRP51E, TYR7B, VAL32B, VAL34E, VAL39E, VAL46E, VAL47B, VAL53E, VAL5B
• B-F: ALA22B, ALA23B, ALA25B, ALA27B, ALA54F, ARG15B, ARG39B, ASN51F, ASP14B, GLN19B, GLN41B, GLN45B, GLN45F, GLU24B, GLU4B, GLU4F, GLU50F, GLY38B, ILE43B, ILE44B, ILE46B, ILE46F, LEU3B, LEU40B, LEU42B, LEU53F, LYS18B, MET2B, PHE21B, PHE29B, PHE6B, PHE6F, PRO13B, PRO36B, PRO37B, PRO49F, SER26B, SER48F, SER8F, THR16B, THR52F, TYR7B, TYR7F, VAL47B, VAL47F, VAL5B, VAL5F
• C-D: ARG5C, ASN51D, GLN45D, GLU4D, PHE32C, PHE6D, VAL55D
• C-E: ALA18C, ALA21C, ALA23C, ALA26C, ALA29C, ALA37C, ARG12C, ARG22C, ARG40C, ARG5C, ARG5E, GLN44C, GLN44E, GLU10C, GLU19C, GLU38C, GLU45C, GLU45E, GLU60E, GLY54E, GLY55E, HIS50E, ILE42C, ILE43C, ILE56E, ILE6C, ILE6E, LEU20C, LEU24C, LEU2C, LEU36C, LEU3C, LEU41C, LEU4C, LEU9E, LYS17C, MET58E, MET8C, MET8E, PRO35C, PRO47E, SER25C, SER57E, THR14C, THR49E, THR52E, THR7E, TRP51E, VAL39C, VAL46E, VAL53E
• C-F: ALA18C, ALA20F, ALA21C, ALA22F, ALA23C, ALA23F, ALA25F, ALA26C, ALA27C, ALA27F, ALA28C, ALA29C, ALA30C, ALA31C, ALA54F, ARG11F, ARG12C, ARG15F, ARG17F, ARG22C, ARG31F, ARG39F, ARG40C, ARG5C, ASN51F, ASP10F, ASP14F, ASP33C, GLN16C, GLN19F, GLN30F, GLN41F, GLN44C, GLN45F, GLU15C, GLU19C, GLU24F, GLU4F, GLY34F, GLY54C, GLY9F, ILE28F, ILE33F, ILE42C, ILE43C, ILE43F, ILE44F, ILE46F, ILE6C, LEU20C, LEU24C, LEU2C, LEU3C, LEU3F, LEU40F, LEU41C, LEU42F, LEU4C, LEU53F, LEU9C, LYS17C, LYS18F, MET1C, MET2F, MET58C, MET8C, PHE21F, PHE29F, PHE32C, PHE6F, PRO12F, PRO13F, PRO1F, PRO36F, PRO49F, SER13C, SER25C, SER26F, SER8F, THR16F, THR35F, THR52F, THR7C, TRP51C, TYR7F, VAL32F, VAL34C, VAL39C, VAL46C, VAL47F, VAL53C, VAL5F
• C-G: ARG12C, ARG12G, GLN16C, GLN16G, GLU15C, GLU15G, GLY11C, GLY11G, LYS17C, LYS17G, SER13C, SER13G, THR14C, THR14G
• C-I: ALA59C, ALA59I, ARG12C, ARG12I, GLU10C, GLU10I, GLY11C, GLY11I, LYS17C, LYS17I, PRO47C, PRO47I, PRO48C, PRO48I, SER13C, SER13I, THR49C, THR49I
• D-E: ARG39D, ARG40E, ARG5E, GLN41D, GLN44E, GLN45D, GLU38E, GLU4D, GLY38D, ILE42E, ILE43D, ILE44D, LEU2E, LEU3D, LEU3E, LEU40D, LEU41E, LEU42D, LEU4E, MET1E, MET2D, PHE6D, PRO1D, PRO36D, THR35D, VAL39E
• D-F: ALA20F, ALA22F, ALA23F, ALA25F, ALA27F, ALA54D, ARG15F, ARG17F, ARG39F, ASN51D, ASP14F, ASP57D, GLN19F, GLN41F, GLN45D, GLN45F, GLU24F, GLU4D, GLU4F, GLU50D, GLY38F, ILE43F, ILE44F, ILE46D, ILE46F, ILE56D, LEU3F, LEU40F, LEU42F, LEU53D, LEU58D, LYS18F, MET2F, PHE21F, PHE29F, PHE6D, PHE6F, PRO12F, PRO13F, PRO36F, PRO37F, PRO49D, SER26F, SER48D, SER8D, THR16F, THR52D, TYR7D, VAL47D, VAL55D, VAL5D, VAL5F
• E-F: ARG5E, ASN51F, GLU4F, MET2F, PHE32E, PHE6F
• E-G: ALA59E, ALA59G, ARG12E, ARG12G, GLU10E, GLU10G, GLY11E, GLY11G, LYS17E, LYS17G, PRO47E, PRO47G, PRO48E, PRO48G, SER13E, SER13G, THR49E, THR49G
• E-K: ARG12E, ARG12K, GLN16E, GLN16K, GLU15E, GLU15K, GLY11E, GLY11K, LYS17E, LYS17K, SER13E, SER13K, THR14E, THR14K
• G-H: ARG5G, ASN51H, GLU4H, PHE32G, PHE6H
• G-I: ALA18G, ALA21G, ALA23G, ALA26G, ALA29G, ALA37G, ARG22G, ARG40G, ARG5G, ARG5I, GLN44G, GLN44I, GLU10G, GLU19G, GLU38G, GLU45G, GLU45I, GLU60I, GLY54I, GLY55I, HIS50I, ILE42G, ILE43G, ILE56I, ILE6G, ILE6I, LEU20G, LEU24G, LEU2G, LEU36G, LEU3G, LEU41G, LEU4G, LEU9I, LYS17G, MET58I, MET8G, MET8I, PRO35G, PRO47I, SER25G, SER57I, THR14G, THR49I, THR52I, THR7I, TRP51I, VAL39G, VAL46I, VAL53I
• G-J: ALA18G, ALA20J, ALA21G, ALA22J, ALA23G, ALA23J, ALA25J, ALA26G, ALA27G, ALA27J, ALA28G, ALA29G, ALA30G, ALA31G, ALA54J, ARG11J, ARG12G, ARG15J, ARG17J, ARG22G, ARG31J, ARG39J, ARG40G, ARG5G, ASN51J, ASP10J, ASP14J, ASP33G, GLN16G, GLN19J, GLN30J, GLN41J, GLN44G, GLN45J, GLU15G, GLU19G, GLU24J, GLU4J, GLY34J, GLY9J, ILE28J, ILE33J, ILE42G, ILE43G, ILE43J, ILE44J, ILE46J, ILE6G, LEU20G, LEU24G, LEU2G, LEU3G, LEU3J, LEU40J, LEU41G, LEU42J, LEU4G, LEU53J, LEU9G, LYS17G, LYS18J, MET1G, MET2J, MET58G, MET8G, PHE21J, PHE29J, PHE32G, PHE6J, PRO12J, PRO13J, PRO1J, PRO36J, PRO49J, SER13G, SER25G, SER26J, SER48J, SER8J, THR16J, THR35J, THR52J, THR7G, TRP51G, TYR7J, VAL32J, VAL34G, VAL39G, VAL46G, VAL47J, VAL53G, VAL5J
• G-K: ALA18K, ALA21K, ALA23K, ALA26K, ALA29K, ALA37K, ARG12K, ARG22K, ARG40K, ARG5G, ARG5K, GLN44G, GLN44K, GLU10K, GLU19K, GLU38K, GLU45G, GLU45K, GLU60G, GLY54G, GLY55G, HIS50G, ILE42K, ILE43K, ILE56G, ILE6G, ILE6K, LEU20K, LEU24K, LEU36K, LEU3K, LEU41K, LEU4K, LEU9G, LYS17K, MET58G, MET8G, MET8K, PRO35K, PRO47G, SER13K, SER25K, SER57G, THR14K, THR49G, THR52G, THR7G, TRP51G, VAL39K, VAL46G, VAL53G
• G-L: ALA37G, ARG39L, ARG40G, ARG5G, GLN41L, GLU38G, GLU4L, GLY38L, ILE42G, ILE43L, ILE44L, LEU2G, LEU3G, LEU3L, LEU40L, LEU42L, LEU4G, MET1G, MET2L, PHE6L, PRO1L, PRO36L, THR35L, VAL39G
• H-I: ALA37I, ARG39H, ARG40I, ARG5I, GLN41H, GLN44I, GLU38I, GLU4H, GLY38H, ILE42I, ILE43H, ILE44H, ILE6I, LEU2I, LEU3H, LEU3I, LEU40H, LEU41I, LEU42H, LEU4I, MET1I, MET2H, PHE6H, PRO1H, PRO36H, THR35H, VAL39I
• H-J: ALA20J, ALA22J, ALA23J, ALA25J, ALA27J, ALA54H, ARG15J, ARG17J, ARG39J, ASN51H, ASP14J, ASP57H, GLN19J, GLN41J, GLN45H, GLN45J, GLU24J, GLU4H, GLU4J, GLU50H, GLY38J, ILE43H, ILE43J, ILE44J, ILE46H, ILE46J, ILE56H, LEU3J, LEU40J, LEU42J, LEU53H, LEU58H, LYS18J, MET2J, PHE21J, PHE6H, PHE6J, PRO12J, PRO13J, PRO36J, PRO37J, PRO49H, SER26J, SER48H, SER8H, THR16J, THR35J, THR52H, TYR7H, VAL47H, VAL55H, VAL5H, VAL5J
• H-K: ALA18K, ALA20H, ALA21K, ALA22H, ALA23K, ALA25H, ALA26K, ALA27H, ALA27K, ALA28K, ALA29K, ALA30K, ALA31K, ALA54H, ARG11H, ARG12K, ARG17H, ARG22K, ARG31H, ARG39H, ARG40K, ARG5K, ASN51H, ASP10H, ASP14H, ASP33K, GLN16K, GLN19H, GLN30H, GLN41H, GLN44K, GLN45H, GLU15K, GLU19K, GLU24H, GLU4H, GLY34H, GLY9H, ILE28H, ILE33H, ILE42K, ILE43H, ILE43K, ILE44H, ILE46H, ILE6K, LEU20K, LEU24K, LEU2K, LEU3H, LEU3K, LEU40H, LEU41K, LEU42H, LEU4K, LEU53H, LEU61K, LEU9K, LYS17K, LYS18H, MET1K, MET2H, MET58K, MET8K, PHE21H, PHE29H, PHE32K, PHE6H, PRO12H, PRO13H, PRO1H, PRO35K, PRO36H, PRO49H, SER13K, SER25K, SER26H, SER8H, THR16H, THR35H, THR52H, THR7K, TRP51K, TYR7H, VAL32H, VAL34K, VAL39K, VAL46K, VAL47H, VAL53K, VAL5H
• H-L: ALA22H, ALA23H, ALA25H, ALA27H, ALA54L, ARG15H, ARG39H, ASN51L, ASP14H, GLN19H, GLN41H, GLN45H, GLN45L, GLU24H, GLU4H, GLU4L, GLU50L, GLY38H, ILE43H, ILE44H, ILE46H, ILE46L, LEU3H, LEU40H, LEU42H, LEU53L, LYS18H, MET2H, PHE21H, PHE29H, PHE6H, PHE6L, PRO13H, PRO36H, PRO37H, PRO49L, SER26H, SER48L, SER8L, THR16H, THR35H, THR52L, TYR7L, VAL47L, VAL5H, VAL5L
• I-J: ARG5I, ASN51J, GLN45J, GLU4J, MET2J, PHE32I, PHE6J, VAL55J
• I-K: ALA18I, ALA21I, ALA23I, ALA26I, ALA29I, ALA37I, ARG22I, ARG40I, ARG5I, ARG5K, GLN44I, GLN44K, GLU10I, GLU19I, GLU38I, GLU45I, GLU45K, GLU60K, GLY54K, GLY55K, HIS50K, ILE42I, ILE43I, ILE56K, ILE6I, ILE6K, LEU20I, LEU24I, LEU2I, LEU36I, LEU3I, LEU41I, LEU4I, LEU9K, LYS17I, MET58K, MET8I, MET8K, PRO35I, PRO47K, SER13I, SER25I, SER57K, THR14I, THR49K, THR52K, THR7K, TRP51K, VAL39I, VAL46K, VAL53K
• I-L: ALA18I, ALA20L, ALA21I, ALA22L, ALA23I, ALA23L, ALA25L, ALA26I, ALA27I, ALA27L, ALA28I, ALA29I, ALA30I, ALA31I, ALA54L, ARG11L, ARG12I, ARG15L, ARG17L, ARG22I, ARG31L, ARG39L, ARG40I, ARG5I, ASN51L, ASP10L, ASP14L, ASP33I, GLN16I, GLN19L, GLN30L, GLN41L, GLN44I, GLN45L, GLU15I, GLU19I, GLU24L, GLU38I, GLU4L, GLY34L, GLY9L, ILE28L, ILE33L, ILE42I, ILE43I, ILE43L, ILE44L, ILE46L, ILE6I, LEU20I, LEU24I, LEU2I, LEU3I, LEU3L, LEU40L, LEU41I, LEU42L, LEU4I, LEU53L, LEU9I, LYS17I, LYS18L, MET1I, MET2L, MET58I, MET8I, PHE21L, PHE29L, PHE32I, PHE6L, PRO12L, PRO13L, PRO1L, PRO35I, PRO36L, PRO49L, SER13I, SER25I, SER26L, SER8L, THR16L, THR35L, THR52L, THR7I, TRP51I, TYR7L, VAL32L, VAL34I, VAL39I, VAL46I, VAL47L, VAL53I, VAL5L
• J-K: ALA37K, ARG39J, ARG40K, ARG5K, GLN41J, GLN45J, GLU38K, GLU4J, GLY38J, ILE42K, ILE43J, ILE44J, LEU2K, LEU3J, LEU3K, LEU40J, LEU42J, LEU4K, MET1K, MET2J, PHE6J, PRO1J, PRO36J, THR35J, VAL39K
• J-L: ALA20L, ALA22L, ALA23L, ALA25L, ALA27L, ALA54J, ARG15L, ARG17L, ARG39L, ASN51J, ASP14L, ASP57J, GLN19L, GLN41L, GLN45J, GLN45L, GLU24L, GLU4J, GLU4L, GLU50J, GLY38L, ILE43L, ILE44L, ILE46J, ILE46L, ILE56J, LEU3L, LEU40L, LEU42L, LEU53J, LEU58J, LYS18L, MET2L, PHE21L, PHE29L, PHE6J, PHE6L, PRO13L, PRO36L, PRO37L, PRO49J, SER26L, SER48J, SER8J, THR16L, THR35L, THR52J, TYR7J, TYR7L, VAL47J, VAL55J, VAL5J, VAL5L
• K-L: ARG5K, ASN51L, GLU4L, MET2L, PHE32K, PHE6L