3MA2

complex membrane type-1 matrix metalloproteinase (mt1-mmp) with tissue inhibitor of metalloproteinase-1 (timp-1)

• Total interactions analyzed: 6
• Total true interactions: 5
• Strongest Interaction:
  • Chains: D-C
  • Int. Res.: 88
  • Norm. En. per Res.: -3.8131
• Hub Node: D(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
D-A	0.0	-6.555	-5.4031	-11.958	19	0	0	785	0	3	4
D-B	-24.9556	-22.0185	-133.114	-180.0881	63	11	0	6024	0	23	22
D-C	-80.1891	-17.6099	-237.752	-335.5509	88	7	3	9225	1	9	6
A-B	-61.1336	-13.9767	-234.206	-309.3163	83	13	4	9338	1	9	6
B-C	0.0	-15.4291	-8.302	-23.731	21	0	0	476	1	7	8

Interface residues

• D-A: ASN122D, GLN115D, GLN120D, GLN281A, GLU248A, GLY116D, GLY246A, HIS121D, HIS249A, LEU117A, LEU117D, LEU282A, LYS118A, LYS118D, PHE204A, PRO207D, PRO259A, SER250A, SER251A
• D-B: ALA255D, ALA258D, ALA365B, ARG276D, ARG277D, ARG337B, ARG375B, ARG379B, ASN378B, ASP252D, ASP273D, ASP274D, ASP275D, GLN115D, GLN280D, GLN281D, GLN331B, GLN336B, GLU248D, GLU328B, GLU339B, GLU367B, GLU381B, GLY116D, GLY246D, GLY278D, GLY284D, GLY285D, GLY325B, GLY371B, HIS243D, HIS249D, HIS374B, HIS377B, ILE279D, LEU117D, LEU247D, LEU282D, LEU398B, LYS118D, MET257D, MET366B, PHE204D, PHE323B, PHE360B, PHE373B, PRO156D, PRO253D, PRO259D, PRO327B, SER250D, SER251D, SER254D, SER368B, SER376B, SER380B, THR326B, THR363B, TYR283D, TYR338B, TYR372B, VAL324B, VAL329B
• D-C: ALA200D, ALA202D, ALA237D, ALA244D, ALA258D, ALA304C, ALA365C, ASN208D, ASN231D, ASN314C, ASP188D, ASP193D, ASP212D, ASP216D, ASP232D, ASP391C, CYS301C, CYS303C, CYS370C, CYS399C, GLN262D, GLN390C, GLU195D, GLU219D, GLU240D, GLU248D, GLU367C, GLY194D, GLY196D, GLY197D, GLY210D, GLY211D, GLY242D, GLY246D, GLY371C, HIS186D, HIS201D, HIS214D, HIS239D, HIS243D, HIS249D, HIS395C, ILE209D, ILE256D, ILE396C, LEU117D, LEU199D, LEU235D, LEU247D, LEU334C, LEU398C, LYS388C, MET257D, MET366C, PHE185D, PHE192D, PHE198D, PHE204D, PHE215D, PHE260D, PHE373C, PHE401C, PRO191D, PRO205D, PRO220D, PRO259D, PRO305C, PRO364C, SER189D, SER250D, SER368C, SER400C, THR190D, THR213D, THR302C, THR332C, THR333C, THR363C, THR397C, TRP221D, TRP263D, TYR203D, TYR261D, TYR335C, VAL236D, VAL306C, VAL369C, VAL402C
• A-B: ALA200A, ALA202A, ALA237A, ALA244A, ALA258A, ALA304B, ALA365B, ASN231A, ASN314B, ASP188A, ASP193A, ASP212A, ASP216A, ASP232A, CYS301B, CYS303B, CYS370B, CYS399B, GLN262A, GLN390B, GLU195A, GLU219A, GLU240A, GLU248A, GLU367B, GLY194A, GLY196A, GLY197A, GLY210A, GLY242A, GLY246A, GLY371B, HIS186A, HIS201A, HIS214A, HIS239A, HIS243A, HIS249A, HIS307B, HIS395B, ILE209A, ILE256A, ILE396B, LEU199A, LEU235A, LEU247A, LEU334B, LEU398B, LYS388B, MET257A, MET366B, PHE185A, PHE192A, PHE198A, PHE204A, PHE215A, PHE260A, PHE401B, PRO191A, PRO220A, PRO259A, PRO305B, PRO364B, SER189A, SER250A, SER368B, SER400B, THR190A, THR213A, THR302B, THR332B, THR333B, THR363B, THR397B, TRP221A, TRP263A, TYR203A, TYR261A, TYR335B, VAL236A, VAL306B, VAL369B, VAL402B
• B-C: ARG375C, ARG379C, ARG413B, ASN378B, ASN378C, ASN406B, GLU367C, GLU381B, GLU381C, GLU382B, HIS374C, HIS377B, LEU398C, LEU410B, PHE373C, PRO404B, SER368C, SER376B, SER376C, SER380B, SER407B