3M9D

crystal structure of the prokaryotic ubiquintin-like protein pup complexed with the hexameric proteasomal atpase mpa which includes the amino terminal coiled coil domain and the inter domain

• Total interactions analyzed: 153
• Total true interactions: 29
• Strongest Interaction:
  • Chains: F-J
  • Int. Res.: 17
  • Norm. En. per Res.: -4.2784
• Hub Node: B(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-32.5926	-22.3448	-366.806	-421.7434	189	15	26	19158	3	68	67
A-D	-53.928	-18.5825	-195.573	-268.0835	103	36	4	9478	3	42	40
A-G	-5.7497	-19.1819	-57.7476	-82.6792	45	18	0	3449	0	24	11
B-E	-57.6756	-23.3001	-206.374	-287.3497	101	30	5	9741	3	39	37
B-G	-4.2334	-10.2585	-61.1108	-75.6027	48	6	0	3366	1	20	19
B-J	0.0	-2.2569	-20.7147	-22.9716	23	1	1	1110	0	4	5
B-K	0.0	0.0	-0.0019	-0.0019	2	0	0	2	0	0	0
C-D	-31.8389	-27.8759	-373.224	-432.9388	191	22	26	19297	5	65	67
C-F	-65.0917	-19.9685	-197.148	-282.2082	101	36	4	9894	3	41	38
C-I	-7.1753	-20.423	-50.9543	-78.5527	42	14	0	3133	0	21	10
D-I	-6.6399	-4.3594	-59.9382	-70.9375	50	10	0	3482	1	20	18
E-F	-23.7052	-18.9806	-375.48	-418.1658	190	16	26	19294	1	67	67
E-H	-2.8715	-11.2076	-58.9311	-73.0102	44	8	0	3041	0	21	10
E-J	-6.1633	-50.6478	-96.1689	-152.98	49	5	1	4731	4	25	25
E-K	0.0	0.0	-0.0747	-0.0747	12	0	0	33	0	0	3
F-H	-4.02	-6.9665	-56.1847	-67.1712	44	5	0	3057	1	19	16
F-J	-9.4818	-22.1685	-41.0824	-72.7327	17	2	0	1398	3	8	9
J-K	-31.0704	-22.9647	-358.134	-412.1691	189	23	24	19044	4	64	67
J-M	-50.1193	-14.6624	-203.616	-268.3976	101	32	6	9818	4	40	38
J-P	-4.0847	-18.8696	-62.0281	-84.9824	43	9	0	3291	0	24	10
K-N	-69.9236	-21.9768	-208.878	-300.7784	102	22	6	9800	3	38	38
K-P	-10.567	5.0321	-57.0483	-62.5832	49	15	0	3680	3	21	19
L-M	-28.5583	-18.6969	-368.13	-415.3852	187	30	24	19074	4	66	67
L-O	-48.9523	-13.7052	-196.411	-259.0684	103	34	4	9475	4	39	38
L-R	-3.9623	-17.7925	-55.5364	-77.2912	42	3	0	2978	0	22	9
M-R	-4.6997	-7.4726	-49.1566	-61.3289	47	11	0	3213	1	19	19
N-O	-38.6319	-19.6928	-375.663	-433.9877	186	28	25	19637	5	66	68
N-Q	-2.8601	-17.2998	-62.7193	-82.8792	46	5	0	3303	0	25	10
O-Q	-3.0944	0.9748	-58.2561	-60.3757	46	6	0	3205	1	20	19

Interface residues

• A-B: ALA106B, ALA132B, ALA146B, ALA157A, ALA169B, ALA174B, ALA180A, ALA180B, ALA226B, ALA53B, ALA61A, ALA61B, ALA67A, ALA67B, ALA68A, ALA68B, ALA80A, ALA80B, ALA86A, ALA86B, ARG120B, ARG123B, ARG142A, ARG165B, ARG173B, ARG184B, ARG232A, ARG62A, ARG62B, ARG69A, ARG69B, ARG81A, ARG81B, ARG88A, ARG88B, ARG93A, ASN129B, ASN144B, ASN70A, ASN70B, ASP110B, ASP111B, ASP114B, ASP170B, ASP181A, ASP181B, ASP223A, ASP55A, ASP55B, ASP64A, ASP64B, ASP92A, CYS126B, GLN58A, GLN58B, GLN82A, GLN82B, GLN83A, GLN83B, GLN96A, GLU151A, GLU156A, GLU160A, GLU166B, GLU182B, GLU183B, GLU231A, GLU60A, GLU60B, GLU75A, GLU75B, GLU79A, GLU79B, GLU89A, GLU89B, GLU90A, GLU90B, GLY100A, GLY102A, GLY119A, GLY119B, GLY153A, GLY159A, GLY178A, GLY178B, GLY227B, GLY95A, HIS108B, HIS172B, HIS179A, HIS179B, HIS57A, HIS57B, ILE130B, ILE161A, ILE167B, ILE233A, ILE56A, ILE56B, ILE63A, ILE63B, LEU105B, LEU124B, LEU143A, LEU143B, LEU147A, LEU147B, LEU168B, LEU175B, LEU188B, LEU221A, LEU235A, LEU59A, LEU59B, LEU66A, LEU66B, LEU73A, LEU73B, LEU77A, LEU77B, LEU84A, LEU84B, LEU85A, LEU85B, LEU87A, LEU87B, LEU94A, LEU94B, LYS121B, LYS225A, LYS225B, LYS72A, LYS72B, LYS78A, LYS78B, MET122B, MET74A, MET74B, PHE116B, PHE155A, PHE230A, PRO128B, PRO234A, PRO237A, PRO97A, PRO98A, SER118A, SER118B, SER127B, SER162A, SER219A, SER52A, SER52B, SER65A, SER65B, SER71A, SER71B, SER99A, THR112B, THR117A, THR125B, THR140A, THR148B, THR154A, THR163A, THR209A, THR224A, THR224B, THR76A, THR76B, TRP187B, TYR101A, TYR228B, VAL103A, VAL113B, VAL115B, VAL141A, VAL149B, VAL150A, VAL150B, VAL158A, VAL176B, VAL177B, VAL185B, VAL186B, VAL222A, VAL236A, VAL91A, VAL91B
• A-D: ALA106A, ALA146A, ALA152D, ALA157D, ALA169A, ALA174A, ALA180A, ALA180D, ALA226A, ARG120A, ARG123A, ARG142D, ARG165A, ARG173A, ARG184A, ARG232D, ASN144A, ASN144D, ASP109A, ASP110A, ASP111A, ASP114A, ASP170A, ASP181A, ASP181D, ASP207D, ASP223D, CYS126A, GLN96D, GLU145A, GLU145D, GLU151D, GLU156D, GLU160D, GLU166A, GLU182A, GLU183A, GLU231D, GLY100D, GLY102D, GLY119D, GLY153D, GLY159D, GLY178D, GLY227A, GLY95D, HIS108A, HIS172A, HIS179D, ILE161D, ILE167A, ILE233D, LEU105A, LEU124A, LEU143A, LEU143D, LEU147A, LEU147D, LEU168A, LEU175A, LEU188A, LEU220D, LEU221D, LEU235D, LYS121A, LYS225A, LYS225D, MET122A, PHE116A, PHE155D, PHE230D, PRO234D, PRO237D, PRO97D, PRO98D, SER118D, SER162D, SER219D, SER99D, THR112A, THR117D, THR125A, THR140D, THR148A, THR154D, THR163D, THR209D, THR224A, THR224D, TRP187A, TYR101D, TYR228A, VAL113A, VAL115A, VAL149A, VAL150D, VAL158D, VAL176A, VAL177A, VAL185A, VAL186A, VAL222D, VAL236D
• A-G: ALA51G, ALA80A, ARG29G, ARG81A, ARG88A, ARG93A, ASN50G, ASN70A, ASP37G, ASP38G, ASP44G, ASP45G, ASP92A, GLN26G, GLN96A, GLU145A, GLU30G, GLU34G, GLU35G, GLU42G, GLU48G, GLU75A, GLU89A, GLY25G, GLY95A, ILE43G, LEU32G, LEU39G, LEU40G, LEU47G, LEU73A, LEU77A, LEU84A, LEU85A, LEU94A, LYS78A, MET74A, PRO97A, PRO98A, SER21G, SER71A, THR33G, THR36G, VAL46G, VAL91A
• B-E: ALA106E, ALA146E, ALA152B, ALA157B, ALA169E, ALA174E, ALA180B, ALA180E, ALA226E, ARG120E, ARG123E, ARG142B, ARG165E, ARG173E, ARG184E, ARG232B, ASN144B, ASN144E, ASP110E, ASP111E, ASP114E, ASP170E, ASP181B, ASP181E, ASP207B, ASP223B, CYS126E, GLN96B, GLU145B, GLU145E, GLU151B, GLU156B, GLU160B, GLU166E, GLU182E, GLU183E, GLU231B, GLY100B, GLY102B, GLY119B, GLY153B, GLY159B, GLY178B, GLY178E, GLY227E, GLY95B, HIS108E, HIS172E, HIS179B, ILE161B, ILE167E, ILE233B, LEU105E, LEU124E, LEU143B, LEU143E, LEU147B, LEU147E, LEU168E, LEU175E, LEU188E, LEU221B, LEU235B, LYS121E, LYS225E, MET122E, PHE116E, PHE155B, PHE230B, PRO216E, PRO234B, PRO237B, PRO97B, PRO98B, SER118B, SER162B, SER219B, SER99B, THR112E, THR117B, THR125E, THR140B, THR148E, THR154B, THR163B, THR209B, THR224B, THR224E, TRP187E, TYR101B, TYR228E, VAL113E, VAL115E, VAL150B, VAL158B, VAL176E, VAL177E, VAL185E, VAL186E, VAL222B, VAL236B
• B-G: ALA146B, ALA51G, ALA68B, ALA80B, ALA86B, ARG28G, ARG29G, ARG69B, ARG81B, ARG93B, ASN144B, ASN50G, ASN70B, ASP38G, ASP45G, GLN82B, GLN83B, GLU145B, GLU35G, GLU42G, GLU48G, GLU49G, GLU75B, GLU79B, GLU89B, GLU90B, GLY25G, ILE43G, LEU147B, LEU32G, LEU39G, LEU40G, LEU47G, LEU66B, LEU73B, LEU77B, LEU87B, LEU94B, LYS72B, SER21G, SER65B, SER71B, THR148B, THR22G, THR33G, THR36G, THR76B, VAL46G
• B-J: ALA204B, ALA61J, ALA67J, ALA68J, ARG69J, ASN206B, ASP207B, ASP64J, GLU60J, GLU75J, ILE63J, LEU205B, LEU235B, LEU66J, LEU73J, LYS72J, LYS78J, MET74J, PRO237B, SER65J, SER71J, THR76J, VAL236B
• B-K: ARG62K, PRO237B
• C-D: ALA106D, ALA132D, ALA146D, ALA152C, ALA157C, ALA169D, ALA174D, ALA180C, ALA180D, ALA226D, ALA53D, ALA61C, ALA61D, ALA67C, ALA67D, ALA68C, ALA68D, ALA80C, ALA80D, ALA86C, ALA86D, ARG120D, ARG123D, ARG142C, ARG165D, ARG173D, ARG184D, ARG232C, ARG62C, ARG62D, ARG69C, ARG69D, ARG81C, ARG81D, ARG88C, ARG88D, ARG93C, ASN129D, ASN144C, ASN144D, ASN70C, ASN70D, ASP110D, ASP111D, ASP114D, ASP170D, ASP181D, ASP223C, ASP55C, ASP55D, ASP64C, ASP64D, ASP92C, CYS126D, GLN58C, GLN58D, GLN82C, GLN82D, GLN83C, GLN83D, GLN96C, GLU145D, GLU151C, GLU156C, GLU160C, GLU166D, GLU182D, GLU183D, GLU231C, GLU60C, GLU60D, GLU75C, GLU75D, GLU79C, GLU79D, GLU89C, GLU89D, GLU90C, GLU90D, GLY100C, GLY102C, GLY119C, GLY119D, GLY153C, GLY159C, GLY178C, GLY178D, GLY227D, GLY95C, HIS108D, HIS172D, HIS179C, HIS179D, HIS57C, HIS57D, ILE130D, ILE161C, ILE167D, ILE233C, ILE56C, ILE56D, ILE63C, ILE63D, LEU105D, LEU124D, LEU143C, LEU143D, LEU147C, LEU147D, LEU168D, LEU175D, LEU188D, LEU221C, LEU235C, LEU59C, LEU59D, LEU66C, LEU66D, LEU73C, LEU73D, LEU77C, LEU77D, LEU84C, LEU84D, LEU85C, LEU85D, LEU87C, LEU87D, LEU94C, LEU94D, LYS121D, LYS225C, LYS225D, LYS72C, LYS72D, LYS78C, LYS78D, MET122D, MET74C, MET74D, PHE116D, PHE155C, PHE230C, PRO128D, PRO234C, PRO237C, PRO97C, PRO98C, SER118C, SER118D, SER127D, SER162C, SER219C, SER52C, SER52D, SER65C, SER65D, SER71C, SER71D, SER99C, THR112D, THR117C, THR125D, THR140C, THR148D, THR154C, THR163C, THR209C, THR224C, THR224D, THR76C, THR76D, TRP187D, TYR101C, TYR228D, VAL103C, VAL113D, VAL115D, VAL141C, VAL149D, VAL150C, VAL150D, VAL158C, VAL176D, VAL177D, VAL185D, VAL186D, VAL222C, VAL236C, VAL91C, VAL91D
• C-F: ALA106C, ALA146C, ALA152F, ALA157F, ALA169C, ALA174C, ALA180C, ALA180F, ALA226C, ARG120C, ARG123C, ARG142F, ARG165C, ARG173C, ARG184C, ARG232F, ASN144F, ASP110C, ASP111C, ASP114C, ASP170C, ASP181C, ASP181F, ASP207F, ASP223F, CYS126C, GLN96F, GLU145C, GLU145F, GLU151F, GLU156F, GLU160F, GLU166C, GLU182C, GLU183C, GLU231F, GLY100F, GLY102F, GLY119F, GLY153F, GLY159F, GLY178F, GLY227C, GLY95F, HIS108C, HIS172C, HIS179F, ILE161F, ILE167C, ILE233F, LEU105C, LEU124C, LEU143C, LEU143F, LEU147C, LEU147F, LEU168C, LEU175C, LEU188C, LEU220F, LEU221F, LEU235F, LYS121C, LYS225C, MET122C, PHE116C, PHE155F, PHE230F, PRO216C, PRO234F, PRO237F, PRO97F, PRO98F, SER118F, SER162F, SER219F, SER99F, THR112C, THR117F, THR125C, THR140F, THR148C, THR154F, THR163F, THR209F, THR224C, THR224F, TRP187C, TYR101F, TYR228C, VAL113C, VAL115C, VAL149C, VAL150F, VAL158F, VAL176C, VAL177C, VAL185C, VAL186C, VAL222F, VAL236F
• C-I: ALA51I, ALA80C, ARG29I, ARG81C, ARG88C, ASN50I, ASN70C, ASP37I, ASP38I, ASP44I, ASP45I, ASP92C, GLN26I, GLN96C, GLU30I, GLU34I, GLU35I, GLU42I, GLU48I, GLU75C, GLU89C, GLY95C, ILE43I, LEU32I, LEU39I, LEU40I, LEU47I, LEU73C, LEU77C, LEU84C, LEU85C, LEU94C, LYS78C, MET74C, PRO97C, PRO98C, SER21I, SER71C, THR33I, THR36I, VAL46I, VAL91C
• D-I: ALA146D, ALA51I, ALA68D, ALA80D, ALA86D, ARG28I, ARG29I, ARG69D, ARG81D, ARG93D, ASN144D, ASN50I, ASN70D, ASP38I, ASP45I, GLN82D, GLN83D, GLU145D, GLU35I, GLU42I, GLU48I, GLU49I, GLU75D, GLU79D, GLU89D, GLU90D, GLY25I, ILE43I, LEU147D, LEU32I, LEU39I, LEU40I, LEU47I, LEU66D, LEU73D, LEU77D, LEU84D, LEU87D, LEU94D, LYS72D, MET74D, SER21I, SER65D, SER71D, THR148D, THR22I, THR33I, THR36I, THR76D, VAL46I
• E-F: ALA106F, ALA132F, ALA146F, ALA157E, ALA169F, ALA174F, ALA180E, ALA180F, ALA226F, ALA53F, ALA61E, ALA61F, ALA67E, ALA67F, ALA68E, ALA68F, ALA80E, ALA80F, ALA86E, ALA86F, ARG120E, ARG120F, ARG123F, ARG142E, ARG165F, ARG173F, ARG184F, ARG232E, ARG62E, ARG62F, ARG69E, ARG69F, ARG81E, ARG81F, ARG88E, ARG88F, ARG93E, ASN129F, ASN144F, ASN70E, ASN70F, ASP110F, ASP111F, ASP114F, ASP170F, ASP181E, ASP181F, ASP223E, ASP55E, ASP55F, ASP64E, ASP64F, ASP92E, CYS126F, GLN58E, GLN58F, GLN82E, GLN82F, GLN83E, GLN83F, GLN96E, GLU145F, GLU151E, GLU156E, GLU160E, GLU166F, GLU182F, GLU183F, GLU231E, GLU60E, GLU60F, GLU75E, GLU75F, GLU79E, GLU79F, GLU89E, GLU89F, GLU90E, GLU90F, GLY100E, GLY102E, GLY119E, GLY119F, GLY159E, GLY178E, GLY178F, GLY227F, GLY95E, HIS108F, HIS172F, HIS179E, HIS179F, HIS57E, HIS57F, ILE130F, ILE161E, ILE167F, ILE233E, ILE56E, ILE56F, ILE63E, ILE63F, LEU105F, LEU124F, LEU143E, LEU143F, LEU147E, LEU147F, LEU168F, LEU175F, LEU188F, LEU221E, LEU235E, LEU59E, LEU59F, LEU66E, LEU66F, LEU73E, LEU73F, LEU77E, LEU77F, LEU84E, LEU84F, LEU85E, LEU85F, LEU87E, LEU87F, LEU94E, LEU94F, LYS121F, LYS225E, LYS225F, LYS72E, LYS72F, LYS78E, LYS78F, MET122F, MET74E, MET74F, PHE116F, PHE155E, PHE230E, PRO128F, PRO234E, PRO237E, PRO97E, PRO98E, SER118E, SER118F, SER127F, SER162E, SER219E, SER52E, SER52F, SER65E, SER65F, SER71E, SER71F, SER99E, THR112F, THR117E, THR125F, THR140E, THR148F, THR154E, THR163E, THR209E, THR224E, THR224F, THR76E, THR76F, TRP187F, TYR101E, TYR228F, VAL103E, VAL113F, VAL115F, VAL141E, VAL149F, VAL150E, VAL150F, VAL158E, VAL176F, VAL177F, VAL185F, VAL186F, VAL222E, VAL236E, VAL91E, VAL91F
• E-H: ALA51H, ALA80E, ARG29H, ARG81E, ARG88E, ARG93E, ASN50H, ASN70E, ASP37H, ASP38H, ASP44H, ASP45H, ASP92E, GLN26H, GLN96E, GLU145E, GLU30H, GLU34H, GLU35H, GLU42H, GLU48H, GLU75E, GLU89E, GLY25H, GLY95E, ILE43H, LEU32H, LEU39H, LEU40H, LEU47H, LEU73E, LEU77E, LEU84E, LEU85E, LEU94E, LYS78E, MET74E, PRO97E, PRO98E, SER21H, THR33H, THR36H, VAL46H, VAL91E
• E-J: ALA180E, ALA53J, ALA61J, ALA68J, ARG165E, ARG212E, ARG215E, ARG232E, ARG54J, ARG62J, ARG69J, ASN206E, ASP181E, ASP208E, ASP218E, ASP55J, ASP64J, GLN58J, GLU166E, GLU182E, GLU183E, GLU203E, GLU60J, GLY178E, GLY217E, HIS179E, HIS57J, ILE161E, ILE167E, ILE233E, ILE56J, ILE63J, LEU164E, LEU175E, LEU220E, LEU235E, LEU59J, LEU66J, PRO216E, PRO234E, PRO237E, SER162E, SER219E, SER52J, SER65J, THR163E, VAL176E, VAL177E, VAL236E
• E-K: ALA204E, ALA67K, ASP64K, GLU203E, GLU60K, GLY217E, ILE56K, ILE63K, LEU235E, PRO202E, PRO237E, SER71K
• F-H: ALA146F, ALA51H, ALA68F, ALA80F, ALA86F, ARG28H, ARG29H, ARG69F, ARG81F, ARG93F, ASN144F, ASN50H, ASN70F, ASP45H, GLN83F, GLU145F, GLU35H, GLU42H, GLU48H, GLU49H, GLU75F, GLU79F, GLU90F, GLY25H, ILE43H, LEU147F, LEU32H, LEU39H, LEU47H, LEU66F, LEU73F, LEU77F, LEU87F, LEU94F, LYS72F, SER21H, SER65F, SER71F, THR148F, THR22H, THR33H, THR36H, THR76F, VAL46H
• F-J: ALA180F, ALA53J, ARG165F, ARG184F, ARG54J, ASP181F, ASP55J, GLU166F, GLU182F, GLU183F, GLY178F, HIS57J, ILE56J, LEU175F, SER52J, VAL177F, VAL185F
• J-K: ALA106K, ALA132K, ALA146K, ALA152J, ALA157J, ALA169K, ALA174K, ALA180J, ALA180K, ALA226K, ALA53K, ALA61J, ALA61K, ALA67J, ALA67K, ALA68J, ALA68K, ALA80J, ALA80K, ALA86J, ALA86K, ARG120K, ARG123K, ARG142J, ARG165K, ARG173K, ARG184K, ARG232J, ARG62J, ARG62K, ARG69J, ARG69K, ARG81J, ARG81K, ARG88J, ARG88K, ARG93J, ASN129K, ASN144J, ASN144K, ASN70J, ASN70K, ASP110K, ASP111K, ASP114K, ASP170K, ASP181K, ASP223J, ASP55J, ASP55K, ASP64J, ASP64K, ASP92J, CYS126K, GLN58J, GLN58K, GLN82J, GLN82K, GLN83J, GLN83K, GLN96J, GLU145K, GLU151J, GLU156J, GLU160J, GLU166K, GLU182K, GLU183K, GLU231J, GLU60J, GLU60K, GLU75J, GLU75K, GLU79J, GLU79K, GLU89J, GLU89K, GLU90J, GLU90K, GLY100J, GLY102J, GLY119J, GLY119K, GLY159J, GLY178J, GLY178K, GLY227K, GLY95J, HIS108K, HIS179J, HIS179K, HIS57J, HIS57K, ILE130K, ILE161J, ILE167K, ILE233J, ILE56J, ILE56K, ILE63J, ILE63K, LEU105K, LEU124K, LEU143J, LEU143K, LEU147J, LEU147K, LEU168K, LEU175K, LEU188K, LEU221J, LEU235J, LEU59J, LEU59K, LEU66J, LEU66K, LEU73J, LEU73K, LEU77J, LEU77K, LEU84J, LEU84K, LEU85J, LEU85K, LEU87J, LEU87K, LEU94J, LEU94K, LYS121K, LYS225J, LYS225K, LYS72J, LYS72K, LYS78J, LYS78K, MET122K, MET74J, MET74K, PHE116K, PHE155J, PHE230J, PRO128K, PRO234J, PRO237J, PRO97J, PRO98J, SER118J, SER118K, SER127K, SER162J, SER219J, SER52J, SER52K, SER65J, SER65K, SER71J, SER71K, SER99J, THR112K, THR117J, THR125K, THR140J, THR148K, THR154J, THR163J, THR209J, THR224J, THR224K, THR76J, THR76K, TRP187K, TYR101J, TYR228K, VAL103J, VAL113K, VAL115K, VAL141J, VAL149K, VAL150J, VAL150K, VAL158J, VAL176K, VAL177K, VAL185K, VAL186K, VAL222J, VAL236J, VAL91J, VAL91K
• J-M: ALA146J, ALA152M, ALA157M, ALA169J, ALA174J, ALA180J, ALA180M, ALA226J, ARG120J, ARG123J, ARG142M, ARG165J, ARG173J, ARG184J, ARG232M, ASN144J, ASN144M, ASP110J, ASP111J, ASP114J, ASP170J, ASP181J, ASP223M, CYS126J, GLN96M, GLU145J, GLU145M, GLU151M, GLU156M, GLU160M, GLU166J, GLU182J, GLU183J, GLU231M, GLY100M, GLY102M, GLY119J, GLY119M, GLY153M, GLY159M, GLY178J, GLY178M, GLY227J, GLY95M, HIS108J, HIS179J, HIS179M, ILE161M, ILE167J, ILE233M, LEU105J, LEU124J, LEU143J, LEU143M, LEU147J, LEU147M, LEU168J, LEU175J, LEU188J, LEU220M, LEU221M, LEU235M, LYS121J, LYS225J, LYS225M, MET122J, PHE116J, PHE155M, PHE230M, PRO234M, PRO237M, PRO97M, PRO98M, SER118M, SER162M, SER219M, SER99M, THR112J, THR117M, THR125J, THR140M, THR148J, THR154M, THR163M, THR209M, THR224J, THR224M, TRP187J, TYR101M, TYR228J, VAL113J, VAL115J, VAL149J, VAL150M, VAL158M, VAL176J, VAL177J, VAL185J, VAL186J, VAL222M, VAL236M
• J-P: ALA51P, ALA80J, ARG29P, ARG81J, ARG88J, ASN50P, ASN70J, ASP37P, ASP38P, ASP44P, ASP45P, ASP92J, GLN26P, GLN96J, GLU30P, GLU34P, GLU35P, GLU42P, GLU48P, GLU75J, GLU89J, GLY25P, GLY95J, ILE43P, LEU32P, LEU39P, LEU40P, LEU47P, LEU73J, LEU77J, LEU84J, LEU85J, LEU94J, LYS78J, MET74J, PRO97J, PRO98J, SER21P, SER71J, THR33P, THR36P, VAL46P, VAL91J
• K-N: ALA106N, ALA146N, ALA152K, ALA157K, ALA169N, ALA174N, ALA180K, ALA180N, ALA226N, ARG120N, ARG123N, ARG142K, ARG165N, ARG173N, ARG184N, ARG232K, ASN144K, ASN144N, ASP110N, ASP111N, ASP114N, ASP170N, ASP181N, ASP223K, CYS126N, GLN96K, GLU145K, GLU145N, GLU151K, GLU156K, GLU160K, GLU166N, GLU182N, GLU183N, GLU231K, GLY100K, GLY102K, GLY119K, GLY119N, GLY153K, GLY159K, GLY178K, GLY227N, GLY95K, HIS108N, HIS172N, HIS179K, ILE161K, ILE167N, ILE233K, LEU105N, LEU124N, LEU143K, LEU143N, LEU147K, LEU147N, LEU168N, LEU175N, LEU188N, LEU220K, LEU221K, LEU235K, LYS121N, LYS225N, MET122N, PHE116N, PHE155K, PHE230K, PRO216N, PRO234K, PRO237K, PRO97K, PRO98K, SER118K, SER118N, SER162K, SER219K, SER99K, THR112N, THR117K, THR125N, THR140K, THR148N, THR154K, THR163K, THR209K, THR224K, THR224N, TRP187N, TYR101K, TYR228N, VAL103K, VAL113N, VAL115N, VAL150K, VAL158K, VAL176N, VAL177N, VAL185N, VAL186N, VAL222K, VAL236K
• K-P: ALA146K, ALA51P, ALA68K, ALA80K, ALA86K, ARG28P, ARG29P, ARG69K, ARG81K, ARG93K, ASN144K, ASN50P, ASN70K, ASP38P, ASP45P, GLN82K, GLN83K, GLU145K, GLU35P, GLU42P, GLU48P, GLU49P, GLU75K, GLU79K, GLU89K, GLU90K, GLY25P, ILE43P, LEU147K, LEU32P, LEU39P, LEU40P, LEU47P, LEU66K, LEU73K, LEU77K, LEU84K, LEU87K, LEU94K, LYS72K, SER21P, SER65K, SER71K, THR148K, THR22P, THR33P, THR36P, THR76K, VAL46P
• L-M: ALA106M, ALA132M, ALA146M, ALA152L, ALA157L, ALA169M, ALA174M, ALA180L, ALA180M, ALA226M, ALA53M, ALA61L, ALA61M, ALA67L, ALA67M, ALA68L, ALA68M, ALA80L, ALA80M, ALA86L, ALA86M, ARG120L, ARG120M, ARG123M, ARG142L, ARG165M, ARG173M, ARG184M, ARG232L, ARG62L, ARG62M, ARG69L, ARG69M, ARG81L, ARG81M, ARG88L, ARG88M, ARG93L, ASN129M, ASN144M, ASN70L, ASN70M, ASP110M, ASP111M, ASP114M, ASP170M, ASP181M, ASP223L, ASP55L, ASP55M, ASP64L, ASP64M, ASP92L, CYS126M, GLN58L, GLN58M, GLN82L, GLN82M, GLN83L, GLN83M, GLN96L, GLU145M, GLU151L, GLU156L, GLU160L, GLU166M, GLU182M, GLU183M, GLU231L, GLU60L, GLU60M, GLU75L, GLU75M, GLU79L, GLU79M, GLU89L, GLU89M, GLU90L, GLU90M, GLY100L, GLY102L, GLY119L, GLY119M, GLY159L, GLY178L, GLY227M, GLY95L, HIS108M, HIS179L, HIS179M, HIS57L, HIS57M, ILE130M, ILE161L, ILE167M, ILE233L, ILE56L, ILE56M, ILE63L, ILE63M, LEU105M, LEU124M, LEU143L, LEU143M, LEU147L, LEU147M, LEU168M, LEU175M, LEU188M, LEU221L, LEU235L, LEU59L, LEU59M, LEU66L, LEU66M, LEU73L, LEU73M, LEU77L, LEU77M, LEU84L, LEU84M, LEU85L, LEU85M, LEU87L, LEU87M, LEU94L, LEU94M, LYS121M, LYS225L, LYS225M, LYS72L, LYS72M, LYS78L, LYS78M, MET122M, MET74L, MET74M, PHE116M, PHE155L, PHE230L, PRO128M, PRO234L, PRO237L, PRO97L, PRO98L, SER118L, SER118M, SER127M, SER162L, SER219L, SER52L, SER52M, SER65L, SER65M, SER71L, SER71M, SER99L, THR112M, THR117L, THR125M, THR140L, THR148M, THR154L, THR209L, THR224L, THR224M, THR76L, THR76M, TRP187M, TYR101L, TYR228M, VAL103L, VAL113M, VAL115M, VAL141L, VAL149M, VAL150L, VAL150M, VAL158L, VAL176M, VAL177M, VAL185M, VAL186M, VAL222L, VAL236L, VAL91L, VAL91M
• L-O: ALA106L, ALA146L, ALA152O, ALA157O, ALA169L, ALA174L, ALA180L, ALA180O, ALA226L, ARG120L, ARG123L, ARG142O, ARG165L, ARG173L, ARG184L, ARG232O, ASN144O, ASP110L, ASP111L, ASP114L, ASP170L, ASP181L, ASP181O, ASP207O, ASP223O, CYS126L, GLN96O, GLU145L, GLU145O, GLU151O, GLU156O, GLU160O, GLU166L, GLU182L, GLU183L, GLU231O, GLY100O, GLY102O, GLY119O, GLY153O, GLY159O, GLY178L, GLY178O, GLY227L, GLY95O, HIS108L, HIS172L, HIS179O, ILE161O, ILE167L, ILE233O, LEU105L, LEU124L, LEU143L, LEU143O, LEU147L, LEU147O, LEU168L, LEU175L, LEU188L, LEU220O, LEU221O, LEU235O, LYS121L, LYS225L, MET122L, PHE116L, PHE155O, PHE230O, PRO216L, PRO234O, PRO237O, PRO97O, PRO98O, SER118O, SER162O, SER219O, SER99O, THR112L, THR117O, THR125L, THR140O, THR148L, THR154O, THR163O, THR209O, THR224L, THR224O, TRP187L, TYR101O, TYR228L, VAL113L, VAL115L, VAL141O, VAL149L, VAL150O, VAL158O, VAL176L, VAL177L, VAL185L, VAL186L, VAL222O, VAL236O
• L-R: ALA51R, ARG29R, ARG81L, ARG88L, ASN50R, ASN70L, ASP37R, ASP38R, ASP44R, ASP45R, ASP92L, GLN26R, GLN96L, GLU145L, GLU30R, GLU34R, GLU35R, GLU42R, GLU48R, GLU75L, GLU89L, GLY25R, GLY95L, ILE43R, LEU32R, LEU39R, LEU40R, LEU47R, LEU73L, LEU77L, LEU84L, LEU85L, LEU94L, LYS78L, MET74L, PRO97L, PRO98L, SER21R, THR33R, THR36R, VAL46R, VAL91L
• M-R: ALA146M, ALA51R, ALA68M, ALA80M, ALA86M, ARG28R, ARG29R, ARG69M, ARG81M, ARG93M, ASN144M, ASN50R, ASN70M, ASP45R, GLN82M, GLN83M, GLU145M, GLU35R, GLU42R, GLU48R, GLU49R, GLU75M, GLU79M, GLU90M, GLY25R, ILE43R, LEU147M, LEU32R, LEU39R, LEU40R, LEU47R, LEU66M, LEU73M, LEU77M, LEU87M, LEU94M, LYS72M, MET74M, SER21R, SER65M, SER71M, THR148M, THR22R, THR33R, THR36R, THR76M, VAL46R
• N-O: ALA106O, ALA132O, ALA146O, ALA157N, ALA169O, ALA174O, ALA180N, ALA180O, ALA226O, ALA53O, ALA61N, ALA61O, ALA67N, ALA67O, ALA68N, ALA68O, ALA80N, ALA80O, ALA86N, ALA86O, ARG120O, ARG123O, ARG142N, ARG165O, ARG173O, ARG184O, ARG232N, ARG62N, ARG62O, ARG69N, ARG69O, ARG81N, ARG81O, ARG88N, ARG88O, ARG93N, ASN129O, ASN144O, ASN70N, ASN70O, ASP110O, ASP111O, ASP114O, ASP170O, ASP181O, ASP223N, ASP55N, ASP55O, ASP64N, ASP64O, ASP92N, CYS126O, GLN58N, GLN58O, GLN82N, GLN82O, GLN83N, GLN83O, GLN96N, GLU145O, GLU151N, GLU156N, GLU160N, GLU166O, GLU182O, GLU183O, GLU231N, GLU60N, GLU60O, GLU75N, GLU75O, GLU79N, GLU79O, GLU89N, GLU89O, GLU90N, GLU90O, GLY100N, GLY102N, GLY119N, GLY119O, GLY153N, GLY159N, GLY178N, GLY227O, GLY95N, HIS108O, HIS179N, HIS179O, HIS57N, HIS57O, ILE130O, ILE161N, ILE167O, ILE233N, ILE56N, ILE56O, ILE63N, ILE63O, LEU105O, LEU124O, LEU143N, LEU143O, LEU147N, LEU147O, LEU168O, LEU175O, LEU188O, LEU221N, LEU235N, LEU59N, LEU59O, LEU66N, LEU66O, LEU73N, LEU73O, LEU77N, LEU77O, LEU84N, LEU84O, LEU85N, LEU85O, LEU87N, LEU87O, LEU94N, LEU94O, LYS121O, LYS225N, LYS225O, LYS72N, LYS72O, LYS78N, LYS78O, MET122O, MET74N, MET74O, PHE116O, PHE155N, PHE230N, PRO128O, PRO234N, PRO237N, PRO97N, PRO98N, SER118N, SER118O, SER127O, SER162N, SER219N, SER52N, SER52O, SER65N, SER65O, SER71N, SER71O, SER99N, THR112O, THR117N, THR125O, THR140N, THR148O, THR154N, THR209N, THR224N, THR224O, THR76N, THR76O, TRP187O, TYR101N, TYR228O, VAL103N, VAL113O, VAL115O, VAL141N, VAL149O, VAL150N, VAL150O, VAL158N, VAL176O, VAL177O, VAL185O, VAL186O, VAL222N, VAL236N, VAL91N, VAL91O
• N-Q: ALA51Q, ALA80N, ARG29Q, ARG81N, ARG88N, ARG93N, ASN50Q, ASN70N, ASP37Q, ASP38Q, ASP44Q, ASP45Q, ASP92N, GLN26Q, GLN96N, GLU145N, GLU30Q, GLU34Q, GLU35Q, GLU42Q, GLU48Q, GLU75N, GLU89N, GLY25Q, GLY95N, ILE43Q, LEU32Q, LEU39Q, LEU40Q, LEU47Q, LEU73N, LEU77N, LEU84N, LEU85N, LEU94N, LYS31Q, LYS78N, MET74N, PRO97N, PRO98N, SER21Q, SER71N, THR33Q, THR36Q, VAL46Q, VAL91N
• O-Q: ALA146O, ALA51Q, ALA68O, ALA80O, ALA86O, ARG28Q, ARG29Q, ARG69O, ARG81O, ARG93O, ASN144O, ASN50Q, ASN70O, ASP45Q, GLN82O, GLN83O, GLU145O, GLU35Q, GLU42Q, GLU48Q, GLU49Q, GLU75O, GLU79O, GLU90O, GLY25Q, ILE43Q, LEU147O, LEU32Q, LEU39Q, LEU40Q, LEU47Q, LEU66O, LEU73O, LEU77O, LEU84O, LEU87O, LEU94O, LYS72O, SER21Q, SER65O, THR148O, THR22Q, THR33Q, THR36Q, THR76O, VAL46Q