3M6S

crystal structure of h1n1pdm hemagglutinin

• Total interactions analyzed: 66
• Total true interactions: 27
• Strongest Interaction:
  • Chains: J-L
  • Int. Res.: 129
  • Norm. En. per Res.: -3.7443
• Hub Node: C(6)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-255.3586	-17.6697	-180.163	-453.1913	222	45	30	29798	3	59	40
A-C	-5.2502	-9.6215	-74.4334	-89.3051	47	2	1	3787	0	21	28
A-D	-36.5604	-44.3134	-91.4961	-172.3699	52	9	0	3756	2	28	20
A-E	-22.0467	-9.943	-93.1548	-125.1445	48	4	1	4304	0	23	31
A-F	0.0	12.6757	-52.117	-39.4413	40	1	0	2628	0	9	10
B-C	0.0	12.6938	-79.9447	-67.2509	40	4	0	3254	0	11	11
B-D	-89.9365	-106.6172	-254.69	-451.2437	122	22	3	12257	11	47	51
B-E	-37.0053	-37.5144	-65.9964	-140.516	50	8	0	3339	2	29	17
B-F	-59.2894	-104.0097	-212.113	-375.412	111	14	3	11191	11	44	49
C-D	-214.8313	-9.1903	-51.5568	-275.5785	219	36	32	30361	3	56	39
C-E	-7.8356	-8.4768	-83.9057	-100.2182	47	6	1	4049	0	24	27
C-F	-37.207	-40.2013	-83.0618	-160.4701	50	7	0	3410	2	28	18
C-G	-9.7415	-3.1401	-25.0198	-37.9013	35	1	0	1403	0	15	13
C-K	-5.2773	-25.3314	-102.075	-132.6837	66	11	1	5061	2	25	22
C-L	0.0	0.0	-0.1148	-0.1148	2	0	0	23	0	0	0
D-E	0.0	15.71	-64.0244	-48.3144	40	2	0	2952	0	10	11
D-F	-72.7373	-107.675	-226.624	-407.0363	111	21	3	11497	10	45	51
E-F	-231.832	-13.1381	-176.036	-421.006	219	43	32	30917	3	54	39
E-K	-6.5772	0.0	-14.5167	-21.0939	16	2	0	818	0	8	9
G-H	-212.4213	-21.5704	-72.3019	-306.2936	216	35	30	29048	4	52	40
G-I	0.0	0.0	-2.2814	-2.2814	16	0	0	264	0	4	4
I-J	-177.7643	-17.9822	-406.814	-602.5606	228	87	31	30938	3	56	40
I-K	-15.5019	-4.4108	-78.8273	-98.7399	47	2	1	3909	0	23	27
I-L	0.0	10.9309	-66.3279	-55.397	40	3	0	3082	0	10	12
J-K	-30.9991	-40.0797	-60.5865	-131.6653	48	8	0	2853	2	26	17
J-L	-103.9021	-119.4254	-259.692	-483.0195	129	24	3	12763	11	51	57
K-L	-187.8463	-21.4495	137.465	-71.8308	213	62	34	30147	3	50	37

Interface residues

• A-B: ALA130B, ALA261A, ALA315A, ALA35B, ALA36B, ALA44B, ALA5B, ALA65B, ALA7B, ALA96B, ALA9A, ARG102A, ARG106B, ARG123B, ARG313A, ARG319A, ARG45A, ASN104B, ASN10A, ASN114B, ASN117B, ASN11A, ASN135B, ASN169B, ASN23A, ASN260A, ASN28B, ASN294A, ASN31A, ASN320A, ASN53B, ASN60B, ASN71B, ASN81B, ASN95B, ASP-2A, ASP109B, ASP112B, ASP145B, ASP17A, ASP19B, ASP1A, ASP37B, ASP85B, ASP86B, ASP90B, ASP94A, ASP97A, CYS137B, CYS144B, CYS148B, CYS279A, CYS303A, CYS4A, GLN27B, GLN280A, GLN293A, GLN30B, GLN62B, GLU100A, GLU103A, GLU103B, GLU105B, GLU11B, GLU120B, GLU139B, GLU150B, GLU21A, GLU29B, GLU57B, GLU69B, GLU74B, GLU81A, GLU97B, GLU99A, GLY0A, GLY12B, GLY134B, GLY136B, GLY13B, GLY16B, GLY20B, GLY23B, GLY262A, GLY264A, GLY301A, GLY317A, GLY31B, GLY33B, GLY67B, GLY6A, GLY8B, HIS111B, HIS142B, HIS25B, HIS26B, HIS28A, HIS296A, HIS72B, HIS8A, ILE10B, ILE133B, ILE265A, ILE266A, ILE267A, ILE298A, ILE300A, ILE45B, ILE48B, ILE56B, ILE57A, ILE5A, ILE6B, ILE77B, ILE91B, ILE96A, LEU101B, LEU102B, LEU108B, LEU118B, LEU126B, LEU20A, LEU290A, LEU2B, LEU312A, LEU314A, LEU318A, LEU32A, LEU33A, LEU3A, LEU44A, LEU73B, LEU89B, LEU98B, LEU99B, LYS116B, LYS121B, LYS131B, LYS143B, LYS153B, LYS22A, LYS302A, LYS305A, LYS308A, LYS311A, LYS51B, LYS58B, LYS68B, MET149B, MET17B, MET59B, PHE138B, PHE140B, PHE292A, PHE63B, PHE70B, PHE88B, PHE95A, PHE9B, PRO-1A, PRO282A, PRO291A, PRO297A, PRO304A, PRO322A, SER106A, SER107A, SER12A, SER263A, SER289A, SER29A, SER309A, SER32B, SER54B, SER77A, THR107B, THR15A, THR15B, THR18A, THR25A, THR277A, THR278A, THR27A, THR288A, THR299A, THR2A, THR310A, THR316A, THR41B, THR49B, THR61B, THR64B, THR93B, TRP14B, TRP21B, TRP92B, TYR110B, TYR119B, TYR141B, TYR22B, TYR24B, TYR306A, TYR34B, TYR78A, TYR7A, TYR94B, TYR98A, VAL100B, VAL115B, VAL122B, VAL152B, VAL16A, VAL18B, VAL19A, VAL24A, VAL26A, VAL307A, VAL30A, VAL321A, VAL52B, VAL55B, VAL66B
• A-C: ALA215C, ARG217C, ARG221C, ARG226C, ASN228C, ASP238A, ASP94C, GLU213C, GLU224C, GLU243A, GLY202A, GLY93C, HIS181C, ILE166A, ILE214C, ILE216C, ILE240A, LYS160A, LYS205A, LYS208A, LYS209A, LYS211A, LYS211C, LYS219C, LYS239A, PHE200A, PHE210A, PHE242A, PRO212C, PRO218C, PRO92C, SER162A, SER164A, SER183C, SER185C, SER204A, SER207A, THR184C, THR203A, THR241A, TYR165A, TYR198A, TYR206A, VAL199A, VAL201A, VAL220C, VAL234A
• A-D: ALA261A, ARG102A, ARG259A, ARG76D, ASN71D, ASN79D, ASP86D, ASP90D, ASP97A, CYS303A, GLN104A, GLU100A, GLU103A, GLU172A, GLU235A, GLU74D, GLU78D, GLU99A, GLY262A, GLY264A, GLY87D, HIS72D, ILE265A, ILE298A, ILE77D, ILE91D, ILE96A, LEU101A, LEU105A, LEU233A, LEU32A, LEU73D, LEU80D, LEU89D, LEU98D, LYS205A, LYS305A, LYS75D, LYS82D, LYS83D, PHE292A, PHE88D, PRO291A, PRO297A, SER106A, SER263A, THR203A, THR232A, TRP231A, TYR206A, TYR94D, TYR98A
• A-E: ALA215A, ARG217A, ARG221A, ARG226A, ASN228A, ASP238E, ASP94A, GLU213A, GLU224A, GLU243E, GLY202E, GLY225A, GLY93A, HIS181A, ILE166E, ILE214A, ILE216A, ILE240E, LYS160E, LYS205E, LYS208E, LYS209E, LYS211A, LYS211E, LYS219A, LYS239E, PHE200E, PHE210E, PHE242E, PRO212A, PRO218A, PRO92A, SER162E, SER164E, SER183A, SER185A, SER204E, SER207E, THR184A, THR203E, THR241E, TYR165E, TYR198E, TYR206E, VAL199E, VAL201E, VAL220A, VAL234E
• A-F: ALA44F, ARG106F, ARG319A, ASN114F, ASN23A, ASN43F, ASN50F, ASN53F, ASN60F, ASP17A, ASP46F, GLN62F, GLU103F, GLU21A, GLU47F, GLU57F, ILE48F, LEU20A, LEU312A, LEU99F, LYS22A, LYS308A, LYS311A, LYS51F, LYS58F, PRO297A, SER309A, SER54F, THR107F, THR18A, THR310A, THR49F, THR61F, TYR110F, TYR306A, VAL19A, VAL24A, VAL307A, VAL52F, VAL55F
• B-C: ALA44B, ARG106B, ARG319C, ASN114B, ASN23C, ASN43B, ASN50B, ASN53B, ASN60B, ASP17C, ASP46B, GLN62B, GLU103B, GLU21C, GLU47B, GLU57B, ILE48B, LEU20C, LEU312C, LEU99B, LYS22C, LYS308C, LYS311C, LYS51B, LYS58B, PRO297C, SER309C, SER54B, THR107B, THR18C, THR310C, THR49B, THR61B, TYR110B, TYR306C, VAL19C, VAL24C, VAL307C, VAL52B, VAL55B
• B-D: ALA5D, ALA65B, ALA96B, ALA96D, ARG106B, ARG106D, ARG123B, ARG123D, ARG170D, ARG76B, ARG76D, ASN104D, ASN114B, ASN117B, ASN128B, ASN135D, ASN43B, ASN50B, ASN53B, ASN60B, ASN71B, ASN79B, ASN79D, ASN81B, ASN81D, ASN95B, ASN95D, ASP109B, ASP109D, ASP112B, ASP112D, ASP85B, ASP85D, ASP86B, ASP86D, ASP90D, GLN125B, GLN62B, GLU103B, GLU103D, GLU105D, GLU120B, GLU120D, GLU132D, GLU171D, GLU47B, GLU57B, GLU69B, GLU74B, GLU78B, GLU78D, GLU97D, GLY134D, GLY4D, GLY67B, GLY87B, GLY87D, GLY8D, HIS111B, ILE133D, ILE56B, ILE77B, ILE77D, ILE84B, ILE84D, ILE91B, ILE91D, LEU101D, LEU102B, LEU102D, LEU2B, LEU2D, LEU80B, LEU80D, LEU89D, LEU98D, LEU99B, LEU99D, LYS116B, LYS116D, LYS121B, LYS127B, LYS131D, LYS167B, LYS39B, LYS51B, LYS58B, LYS68B, LYS75D, LYS82B, LYS82D, LYS83B, LYS83D, MET59B, PHE3B, PHE3D, PHE63B, PHE70B, PHE88B, PHE88D, PHE9D, PRO160B, SER113B, SER113D, SER124B, SER54B, THR107B, THR107D, THR61B, THR64B, THR93D, TRP92B, TRP92D, TYR110B, TYR119D, TYR141D, TYR159B, TYR94D, VAL100D, VAL52B, VAL55B, VAL66B
• B-E: ALA261E, ARG102E, ARG259E, ARG76B, ASN71B, ASN79B, ASP86B, ASP90B, ASP97E, CYS303E, GLN104E, GLU100E, GLU103E, GLU172E, GLU235E, GLU74B, GLU78B, GLU99E, GLY262E, GLY264E, GLY87B, HIS72B, ILE265E, ILE298E, ILE77B, ILE91B, ILE96E, LEU101E, LEU233E, LEU32E, LEU73B, LEU80B, LEU89B, LEU98B, LYS205E, LYS305E, LYS75B, LYS82B, LYS83B, PHE292E, PRO291E, PRO297E, SER106E, SER263E, THR232E, THR299E, TRP231E, TYR206E, TYR94B, TYR98E
• B-F: ALA5B, ALA65F, ALA96B, ALA96F, ARG106B, ARG106F, ARG123B, ARG123F, ARG76B, ARG76F, ASN114F, ASN117F, ASN135B, ASN43F, ASN50F, ASN53F, ASN60F, ASN71F, ASN79B, ASN79F, ASN81B, ASN81F, ASN95B, ASN95F, ASP109B, ASP109F, ASP112B, ASP85B, ASP85F, ASP86B, ASP86F, ASP90B, GLN62F, GLU103B, GLU103F, GLU105B, GLU120B, GLU120F, GLU132B, GLU47F, GLU57F, GLU69F, GLU74F, GLU78B, GLU78F, GLU97B, GLY134B, GLY4B, GLY67F, GLY87B, GLY87F, GLY8B, ILE133B, ILE56F, ILE77B, ILE77F, ILE84B, ILE84F, ILE91B, ILE91F, LEU101B, LEU102B, LEU102F, LEU2B, LEU2F, LEU80B, LEU80F, LEU89B, LEU89F, LEU98B, LEU99F, LYS116B, LYS116F, LYS121F, LYS127F, LYS131B, LYS51F, LYS58F, LYS68F, LYS75B, LYS82B, LYS82F, LYS83B, LYS83F, MET59F, PHE3B, PHE3F, PHE63F, PHE70F, PHE88B, PHE88F, PHE9B, SER113B, SER113F, SER124F, SER54F, THR107B, THR61F, THR64F, THR93B, TRP92B, TRP92F, TYR110F, TYR119B, TYR141B, TYR159F, TYR94B, VAL100B, VAL52F, VAL55F, VAL66F
• C-D: ALA130D, ALA261C, ALA315C, ALA35D, ALA36D, ALA44D, ALA5D, ALA65D, ALA7D, ALA96D, ALA9C, ARG102C, ARG106D, ARG123D, ARG313C, ARG319C, ARG45C, ASN104D, ASN10C, ASN114D, ASN117D, ASN11C, ASN135D, ASN169D, ASN23C, ASN260C, ASN28D, ASN294C, ASN31C, ASN320C, ASN53D, ASN60D, ASN71D, ASN81D, ASN95D, ASP109D, ASP112D, ASP145D, ASP17C, ASP19D, ASP1C, ASP37D, ASP85D, ASP86D, ASP90D, ASP94C, ASP97C, CYS137D, CYS144D, CYS148D, CYS279C, CYS303C, CYS4C, GLN125D, GLN27D, GLN280C, GLN293C, GLN30D, GLN62D, GLU100C, GLU103C, GLU103D, GLU105D, GLU11D, GLU120D, GLU132D, GLU139D, GLU150D, GLU21C, GLU29D, GLU57D, GLU69D, GLU74D, GLU81C, GLU97D, GLU99C, GLY0C, GLY12D, GLY134D, GLY136D, GLY13D, GLY16D, GLY20D, GLY23D, GLY262C, GLY264C, GLY301C, GLY317C, GLY33D, GLY67D, GLY6C, GLY8D, HIS111D, HIS142D, HIS25D, HIS26D, HIS28C, HIS296C, HIS72D, HIS8C, ILE10D, ILE133D, ILE265C, ILE266C, ILE267C, ILE298C, ILE300C, ILE45D, ILE48D, ILE56D, ILE57C, ILE5C, ILE6D, ILE91D, ILE96C, LEU101D, LEU102D, LEU108D, LEU118D, LEU126D, LEU20C, LEU290C, LEU2D, LEU312C, LEU314C, LEU318C, LEU32C, LEU33C, LEU3C, LEU44C, LEU89D, LEU98D, LEU99D, LYS116D, LYS121D, LYS131D, LYS143D, LYS153D, LYS22C, LYS302C, LYS305C, LYS308C, LYS311C, LYS51D, LYS58D, LYS68D, MET149D, MET17D, MET59D, PHE138D, PHE140D, PHE292C, PHE63D, PHE70D, PHE88D, PHE9D, PRO282C, PRO291C, PRO297C, PRO304C, PRO322C, SER106C, SER107C, SER12C, SER263C, SER289C, SER29C, SER309C, SER32D, SER54D, SER77C, THR107D, THR15C, THR15D, THR18C, THR25C, THR277C, THR278C, THR27C, THR288C, THR299C, THR2C, THR310C, THR316C, THR41D, THR49D, THR61D, THR64D, THR93D, TRP14D, TRP21D, TRP92D, TYR110D, TYR119D, TYR141D, TYR157D, TYR22D, TYR24D, TYR306C, TYR34D, TYR78C, TYR7C, TYR94D, TYR98C, VAL100D, VAL115D, VAL122D, VAL152D, VAL16C, VAL18D, VAL19C, VAL24C, VAL26C, VAL307C, VAL30C, VAL321C, VAL52D, VAL55D, VAL66D
• C-E: ALA215E, ARG217E, ARG221E, ARG226E, ASN228E, ASP238C, ASP94E, GLU213E, GLU224E, GLU243C, GLY202C, GLY225E, GLY93E, HIS181E, ILE166C, ILE214E, ILE216E, ILE240C, LYS160C, LYS205C, LYS208C, LYS209C, LYS211C, LYS211E, LYS219E, LYS239C, PHE200C, PHE210C, PHE242C, PRO212E, PRO218E, PRO92E, SER162C, SER164C, SER183E, SER204C, SER207C, THR184E, THR203C, THR241C, TYR165C, TYR198C, TYR206C, VAL199C, VAL201C, VAL220E, VAL234C
• C-F: ALA261C, ARG102C, ARG259C, ARG76F, ASN71F, ASN79F, ASP86F, ASP90F, ASP97C, CYS303C, GLN104C, GLU100C, GLU103C, GLU172C, GLU235C, GLU74F, GLU78F, GLU99C, GLY262C, GLY264C, GLY87F, HIS72F, ILE265C, ILE298C, ILE77F, ILE91F, ILE96C, LEU101C, LEU105C, LEU233C, LEU32C, LEU73F, LEU80F, LEU89F, LEU98F, LYS205C, LYS305C, LYS75F, LYS82F, LYS83F, PHE292C, PRO291C, PRO297C, SER106C, SER263C, THR232C, TRP231C, TYR206C, TYR94F, TYR98C
• C-G: ALA139C, ALA141C, ALA261G, ARG259G, ARG45G, ASN129C, ASN156C, ASN167G, ASN260G, ASP127C, ASP168G, GLU172G, GLU235G, GLU258G, GLY140C, GLY155C, GLY170G, GLY237G, GLY262G, ILE166G, LYS130C, LYS142C, LYS153C, LYS169G, LYS171G, PRO236G, SER107G, SER109G, SER110G, SER143C, SER190C, VAL108G, VAL132C, VAL152C, VAL47G
• C-K: ALA256K, ALA261K, ALA48K, ALA73K, ARG259K, ARG45K, ASN125C, ASN167C, ASN167K, ASN260K, ASN276K, ASP168C, ASP168K, ASP238C, ASP238K, GLU112K, GLU172K, GLU235C, GLU235K, GLU243C, GLU258K, GLY170C, GLY170K, GLY237C, GLY237K, GLY46K, HIS126C, ILE116C, ILE166C, ILE240C, LEU161C, LEU44K, LYS160C, LYS163C, LYS169C, LYS169K, LYS171C, LYS171K, LYS239C, LYS302K, LYS43K, MET257K, PHE111K, PHE117C, PHE242C, PRO124C, PRO159C, PRO236C, PRO236K, SER107K, SER109K, SER110K, SER121C, SER122C, SER162C, SER164C, SER74K, SER75K, SER77K, THR241C, THR278K, TRP123C, TRP76K, TYR165C, VAL108K, VAL47K
• C-L: ASP168C, PHE63L
• D-E: ALA44D, ARG106D, ARG319E, ASN114D, ASN23E, ASN43D, ASN50D, ASN53D, ASN60D, ASP17E, ASP46D, GLN62D, GLU103D, GLU21E, GLU47D, GLU57D, ILE48D, LEU20E, LEU312E, LEU99D, LYS22E, LYS308E, LYS311E, LYS51D, LYS58D, PRO297E, SER309E, SER54D, THR107D, THR18E, THR310E, THR49D, THR61D, TYR110D, TYR306E, VAL19E, VAL24E, VAL307E, VAL52D, VAL55D
• D-F: ALA5F, ALA65D, ALA96D, ALA96F, ARG106D, ARG106F, ARG123D, ARG123F, ARG76D, ARG76F, ASN114D, ASN117D, ASN135F, ASN43D, ASN50D, ASN53D, ASN60D, ASN71D, ASN79D, ASN79F, ASN81D, ASN81F, ASN95D, ASN95F, ASP109D, ASP109F, ASP112F, ASP85D, ASP85F, ASP86D, ASP86F, ASP90F, GLN62D, GLU103D, GLU103F, GLU105F, GLU120D, GLU120F, GLU132F, GLU47D, GLU57D, GLU69D, GLU74D, GLU78D, GLU78F, GLU97F, GLY134F, GLY4F, GLY67D, GLY87D, GLY87F, GLY8F, ILE133F, ILE56D, ILE77D, ILE77F, ILE84D, ILE84F, ILE91D, ILE91F, LEU101F, LEU102D, LEU102F, LEU2D, LEU2F, LEU80D, LEU80F, LEU89F, LEU98F, LEU99D, LEU99F, LYS116D, LYS116F, LYS121D, LYS127D, LYS131F, LYS51D, LYS58D, LYS68D, LYS75F, LYS82D, LYS82F, LYS83D, LYS83F, MET59D, PHE3D, PHE3F, PHE63D, PHE70D, PHE88D, PHE88F, PHE9F, SER113D, SER113F, SER124D, SER54D, THR107D, THR61D, THR64D, THR93F, TRP92D, TRP92F, TYR110D, TYR119F, TYR141F, TYR159D, TYR94F, VAL100F, VAL52D, VAL55D, VAL66D
• E-F: ALA130F, ALA261E, ALA315E, ALA35F, ALA36F, ALA44F, ALA5F, ALA65F, ALA7F, ALA96F, ALA9E, ARG102E, ARG106F, ARG123F, ARG313E, ARG319E, ARG45E, ASN104F, ASN10E, ASN114F, ASN117F, ASN11E, ASN135F, ASN169F, ASN23E, ASN260E, ASN28F, ASN294E, ASN31E, ASN320E, ASN53F, ASN60F, ASN71F, ASN81F, ASN95F, ASP109F, ASP112F, ASP145F, ASP17E, ASP19F, ASP1E, ASP37F, ASP85F, ASP86F, ASP90F, ASP94E, ASP97E, CYS137F, CYS144F, CYS148F, CYS279E, CYS303E, CYS4E, GLN125F, GLN27F, GLN280E, GLN293E, GLN30F, GLN62F, GLU100E, GLU103E, GLU103F, GLU105F, GLU11F, GLU120F, GLU139F, GLU150F, GLU21E, GLU29F, GLU57F, GLU69F, GLU74F, GLU81E, GLU97F, GLU99E, GLY0E, GLY12F, GLY134F, GLY136F, GLY13F, GLY16F, GLY20F, GLY23F, GLY262E, GLY264E, GLY301E, GLY317E, GLY31F, GLY33F, GLY67F, GLY6E, GLY8F, HIS111F, HIS142F, HIS25F, HIS26F, HIS28E, HIS296E, HIS72F, HIS8E, ILE10F, ILE133F, ILE265E, ILE266E, ILE267E, ILE298E, ILE300E, ILE45F, ILE48F, ILE56F, ILE57E, ILE5E, ILE6F, ILE91F, ILE96E, LEU101F, LEU102F, LEU108F, LEU118F, LEU126F, LEU20E, LEU290E, LEU2F, LEU312E, LEU314E, LEU318E, LEU32E, LEU33E, LEU3E, LEU44E, LEU89F, LEU98F, LEU99F, LYS116F, LYS121F, LYS131F, LYS143F, LYS153F, LYS22E, LYS302E, LYS305E, LYS308E, LYS311E, LYS51F, LYS58F, LYS68F, MET149F, MET17F, MET59F, PHE138F, PHE140F, PHE292E, PHE63F, PHE70F, PHE88F, PHE9F, PRO282E, PRO291E, PRO297E, PRO304E, PRO322E, SER106E, SER107E, SER12E, SER263E, SER289E, SER29E, SER309E, SER32F, SER54F, SER77E, THR107F, THR15E, THR15F, THR18E, THR25E, THR277E, THR278E, THR27E, THR288E, THR299E, THR2E, THR310E, THR316E, THR41F, THR49F, THR61F, THR64F, THR93F, TRP14F, TRP21F, TRP92F, TYR110F, TYR119F, TYR141F, TYR157F, TYR22F, TYR24F, TYR306E, TYR34F, TYR78E, TYR7E, TYR94F, TYR98E, VAL100F, VAL115F, VAL122F, VAL152F, VAL16E, VAL18F, VAL19E, VAL24E, VAL26E, VAL307E, VAL30E, VAL321E, VAL52F, VAL55F, VAL66F
• E-K: ALA73K, ARG217E, ARG221E, ASP222E, ASP274K, GLU112K, GLU224E, ILE216E, LYS219E, PHE111K, PRO218E, SER71K, SER74K, SER75K, THR184E, THR72K
• G-H: ALA130H, ALA261G, ALA315G, ALA35H, ALA36H, ALA44H, ALA5H, ALA65H, ALA7H, ALA96H, ALA9G, ARG102G, ARG106H, ARG123H, ARG313G, ARG319G, ARG45G, ASN104H, ASN10G, ASN114H, ASN117H, ASN11G, ASN135H, ASN169H, ASN23G, ASN260G, ASN28H, ASN294G, ASN31G, ASN320G, ASN53H, ASN60H, ASN71H, ASN81H, ASN95H, ASP109H, ASP112H, ASP145H, ASP17G, ASP19H, ASP1G, ASP37H, ASP85H, ASP86H, ASP90H, ASP94G, ASP97G, CYS137H, CYS144H, CYS148H, CYS279G, CYS303G, CYS4G, GLN27H, GLN280G, GLN293G, GLN30H, GLN62H, GLU100G, GLU103G, GLU103H, GLU105H, GLU11H, GLU120H, GLU139H, GLU150H, GLU21G, GLU29H, GLU57H, GLU69H, GLU74H, GLU81G, GLU97H, GLU99G, GLY12H, GLY134H, GLY136H, GLY13H, GLY16H, GLY20H, GLY23H, GLY262G, GLY264G, GLY301G, GLY317G, GLY31H, GLY33H, GLY67H, GLY6G, GLY8H, HIS111H, HIS142H, HIS25H, HIS26H, HIS28G, HIS296G, HIS72H, HIS8G, ILE10H, ILE133H, ILE265G, ILE266G, ILE267G, ILE298G, ILE300G, ILE45H, ILE48H, ILE56H, ILE57G, ILE5G, ILE6H, ILE91H, ILE96G, LEU101H, LEU102H, LEU108H, LEU118H, LEU126H, LEU20G, LEU290G, LEU2H, LEU312G, LEU314G, LEU318G, LEU32G, LEU33G, LEU3G, LEU44G, LEU89H, LEU98H, LEU99H, LYS116H, LYS121H, LYS131H, LYS143H, LYS153H, LYS22G, LYS302G, LYS305G, LYS308G, LYS311G, LYS51H, LYS58H, LYS68H, MET149H, MET17H, MET59H, PHE138H, PHE140H, PHE292G, PHE63H, PHE70H, PHE88H, PHE9H, PRO282G, PRO291G, PRO297G, PRO304G, PRO322G, SER106G, SER107G, SER263G, SER289G, SER29G, SER309G, SER32H, SER54H, SER77G, THR107H, THR15G, THR15H, THR18G, THR25G, THR277G, THR278G, THR27G, THR281G, THR288G, THR299G, THR2G, THR310G, THR316G, THR41H, THR49H, THR61H, THR64H, THR93H, TRP14H, TRP21H, TRP92H, TYR110H, TYR119H, TYR141H, TYR22H, TYR24H, TYR306G, TYR34H, TYR78G, TYR7G, TYR94H, TYR98G, VAL100H, VAL115H, VAL122H, VAL152H, VAL16G, VAL18H, VAL19G, VAL24G, VAL26G, VAL307G, VAL30G, VAL321G, VAL52H, VAL55H, VAL66H
• G-I: ALA134I, ALA139I, ALA141I, ARG252G, ASP274G, GLU115G, GLY140I, HIS138I, HIS273I, LYS119G, LYS142I, LYS146G, PRO137I, PRO271I, THR120G, TYR253G
• I-J: ALA130J, ALA261I, ALA315I, ALA35J, ALA36J, ALA44J, ALA5J, ALA65J, ALA7J, ALA96J, ALA9I, ARG102I, ARG106J, ARG123J, ARG313I, ARG319I, ARG45I, ASN104J, ASN10I, ASN114J, ASN117J, ASN11I, ASN135J, ASN146J, ASN154J, ASN169J, ASN23I, ASN260I, ASN28J, ASN294I, ASN31I, ASN320I, ASN53J, ASN60J, ASN71J, ASN81J, ASN95J, ASP109J, ASP112J, ASP145J, ASP17I, ASP19J, ASP1I, ASP37J, ASP85J, ASP86J, ASP90J, ASP94I, ASP97I, CYS137J, CYS144J, CYS148J, CYS279I, CYS303I, CYS4I, GLN125J, GLN27J, GLN280I, GLN293I, GLN30J, GLN62J, GLU100I, GLU103I, GLU103J, GLU105J, GLU11J, GLU120J, GLU139J, GLU150J, GLU21I, GLU29J, GLU57J, GLU69J, GLU74J, GLU81I, GLU97J, GLU99I, GLY0I, GLY12J, GLY136J, GLY13J, GLY155J, GLY16J, GLY20J, GLY23J, GLY262I, GLY264I, GLY301I, GLY317I, GLY31J, GLY33J, GLY67J, GLY6I, GLY8J, HIS111J, HIS142J, HIS25J, HIS26J, HIS28I, HIS296I, HIS72J, HIS8I, ILE10J, ILE133J, ILE265I, ILE266I, ILE267I, ILE298I, ILE300I, ILE45J, ILE48J, ILE56J, ILE57I, ILE5I, ILE6J, ILE77J, ILE79I, ILE91J, ILE96I, LEU101I, LEU101J, LEU102J, LEU108J, LEU118J, LEU126J, LEU20I, LEU290I, LEU2J, LEU312I, LEU314I, LEU318I, LEU32I, LEU33I, LEU3I, LEU44I, LEU73J, LEU89J, LEU98J, LEU99J, LYS116J, LYS121J, LYS131J, LYS143J, LYS153J, LYS22I, LYS302I, LYS305I, LYS308I, LYS311I, LYS51J, LYS58J, LYS68J, LYS82J, MET149J, MET17J, MET59J, PHE138J, PHE140J, PHE292I, PHE63J, PHE70J, PHE88J, PHE95I, PHE9J, PRO282I, PRO291I, PRO297I, PRO304I, SER106I, SER107I, SER12I, SER151J, SER263I, SER289I, SER29I, SER309I, SER32J, SER40J, SER54J, SER77I, THR107J, THR15I, THR15J, THR18I, THR25I, THR277I, THR278I, THR27I, THR288I, THR299I, THR2I, THR310I, THR316I, THR41J, THR49J, THR61J, THR64J, THR93J, TRP14J, TRP21J, TRP92J, TYR110J, TYR119J, TYR141J, TYR157J, TYR22J, TYR24J, TYR306I, TYR34J, TYR78I, TYR7I, TYR94J, TYR98I, VAL100J, VAL115J, VAL122J, VAL152J, VAL16I, VAL18J, VAL19I, VAL24I, VAL26I, VAL307I, VAL30I, VAL321I, VAL52J, VAL55J, VAL66J
• I-K: ALA215I, ARG217I, ARG221I, ARG226I, ASN228I, ASP238K, ASP94I, GLU213I, GLU224I, GLU243K, GLY202K, GLY93I, HIS181I, ILE166K, ILE214I, ILE216I, ILE240K, LYS160K, LYS205K, LYS208K, LYS209K, LYS211I, LYS211K, LYS219I, LYS239K, PHE200K, PHE210K, PHE242K, PRO212I, PRO218I, PRO92I, SER162K, SER164K, SER183I, SER185I, SER204K, SER207K, THR184I, THR203K, THR241K, TYR165K, TYR198K, TYR206K, VAL199K, VAL201K, VAL220I, VAL234K
• I-L: ALA44L, ARG106L, ARG319I, ASN114L, ASN23I, ASN43L, ASN50L, ASN53L, ASN60L, ASP17I, ASP46L, GLN62L, GLU103L, GLU21I, GLU47L, GLU57L, ILE48L, LEU20I, LEU312I, LEU99L, LYS22I, LYS308I, LYS311I, LYS51L, LYS58L, PRO297I, SER309I, SER54L, THR107L, THR18I, THR310I, THR49L, THR61L, TYR110L, TYR306I, VAL19I, VAL24I, VAL307I, VAL52L, VAL55L
• J-K: ALA261K, ARG102K, ARG259K, ARG76J, ASN71J, ASN79J, ASP86J, ASP90J, ASP97K, CYS303K, GLN104K, GLU100K, GLU103K, GLU74J, GLU78J, GLU99K, GLY262K, GLY264K, GLY87J, HIS72J, ILE298K, ILE77J, ILE91J, ILE96K, LEU101K, LEU233K, LEU32K, LEU73J, LEU80J, LEU89J, LEU98J, LYS205K, LYS305K, LYS75J, LYS82J, LYS83J, PHE292K, PHE88J, PRO291K, PRO297K, SER106K, SER263K, THR232K, THR299K, TRP231K, TYR206K, TYR94J, TYR98K
• J-L: ALA130J, ALA5J, ALA65L, ALA96J, ALA96L, ARG106J, ARG106L, ARG123J, ARG123L, ARG170J, ARG76J, ARG76L, ASN104J, ASN114L, ASN117L, ASN128J, ASN128L, ASN135J, ASN43L, ASN50L, ASN53L, ASN60L, ASN71L, ASN79J, ASN79L, ASN81J, ASN81L, ASN95J, ASN95L, ASP109J, ASP109L, ASP112J, ASP112L, ASP85J, ASP85L, ASP86J, ASP86L, ASP90J, CYS137J, GLN125L, GLN62L, GLU103J, GLU103L, GLU105J, GLU120J, GLU120L, GLU132J, GLU139J, GLU171J, GLU47L, GLU57L, GLU69L, GLU74L, GLU78J, GLU78L, GLU97J, GLY134J, GLY136J, GLY4J, GLY67L, GLY87J, GLY87L, GLY8J, HIS111L, ILE133J, ILE48L, ILE56L, ILE77J, ILE77L, ILE84J, ILE84L, ILE91J, ILE91L, LEU101J, LEU102J, LEU102L, LEU118L, LEU2J, LEU2L, LEU80J, LEU80L, LEU89J, LEU98J, LEU99J, LEU99L, LYS116J, LYS116L, LYS121L, LYS127L, LYS131J, LYS167L, LYS39L, LYS51L, LYS58L, LYS68L, LYS75J, LYS82J, LYS82L, LYS83J, LYS83L, MET59L, PHE3J, PHE3L, PHE63L, PHE70L, PHE88J, PHE88L, PHE9J, PRO160L, SER113J, SER113L, SER124L, SER54L, THR107J, THR107L, THR61L, THR64L, THR93J, TRP92J, TRP92L, TYR110L, TYR119J, TYR141J, TYR159L, TYR94J, VAL100J, VAL52L, VAL55L, VAL66L
• K-L: ALA130L, ALA261K, ALA315K, ALA35L, ALA36L, ALA44L, ALA5L, ALA65L, ALA7L, ALA96L, ALA9K, ARG102K, ARG106L, ARG123L, ARG313K, ARG319K, ARG45K, ASN104L, ASN10K, ASN114L, ASN117L, ASN11K, ASN135L, ASN23K, ASN260K, ASN28L, ASN294K, ASN31K, ASN320K, ASN53L, ASN60L, ASN71L, ASN81L, ASN95L, ASP109L, ASP112L, ASP17K, ASP19L, ASP37L, ASP85L, ASP86L, ASP90L, ASP94K, ASP97K, CYS137L, CYS144L, CYS148L, CYS279K, CYS303K, CYS4K, GLN125L, GLN27L, GLN280K, GLN293K, GLN62L, GLU100K, GLU103K, GLU103L, GLU105L, GLU11L, GLU120L, GLU132L, GLU139L, GLU150L, GLU21K, GLU57L, GLU69L, GLU74L, GLU81K, GLU97L, GLU99K, GLY12L, GLY134L, GLY136L, GLY13L, GLY16L, GLY20L, GLY23L, GLY262K, GLY264K, GLY301K, GLY317K, GLY4L, GLY67L, GLY6K, GLY8L, HIS111L, HIS142L, HIS25L, HIS26L, HIS28K, HIS296K, HIS72L, HIS8K, ILE10L, ILE133L, ILE265K, ILE266K, ILE267K, ILE298K, ILE300K, ILE45L, ILE48L, ILE56L, ILE57K, ILE5K, ILE6L, ILE91L, ILE96K, LEU101K, LEU101L, LEU102L, LEU108L, LEU118L, LEU126L, LEU20K, LEU290K, LEU2L, LEU312K, LEU314K, LEU318K, LEU32K, LEU33K, LEU3K, LEU44K, LEU89L, LEU98L, LEU99L, LYS116L, LYS121L, LYS131L, LYS143L, LYS153L, LYS22K, LYS302K, LYS305K, LYS308K, LYS311K, LYS51L, LYS58L, LYS68L, MET149L, MET17L, MET59L, PHE138L, PHE140L, PHE292K, PHE63L, PHE70L, PHE88L, PHE9L, PRO282K, PRO291K, PRO297K, PRO304K, PRO322K, SER106K, SER107K, SER12K, SER263K, SER289K, SER29K, SER309K, SER54L, SER77K, THR107L, THR15K, THR15L, THR18K, THR25K, THR277K, THR278K, THR27K, THR288K, THR299K, THR2K, THR310K, THR316K, THR41L, THR49L, THR61L, THR64L, THR93L, TRP14L, TRP21L, TRP92L, TYR110L, TYR119L, TYR141L, TYR157L, TYR22L, TYR24L, TYR306K, TYR34L, TYR78K, TYR7K, TYR94L, TYR98K, VAL100L, VAL115L, VAL122L, VAL152L, VAL16K, VAL18L, VAL19K, VAL24K, VAL26K, VAL307K, VAL30K, VAL321K, VAL52L, VAL55L, VAL66L