3M3R

crystal structure of the m113f alpha-hemolysin mutant complexed with beta-cyclodextrin

• Total interactions analyzed: 21
• Total true interactions: 18
• Strongest Interaction:
  • Chains: B-C
  • Int. Res.: 260
  • Norm. En. per Res.: -4.8235
• Hub Node: A(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-301.294	-94.1545	-801.218	-1196.6665	258	62	14	30850	10	75	79
A-C	-14.3313	5.4505	-31.7598	-40.6406	32	1	0	1235	0	4	3
A-D	0.0	0.0	-0.0842	-0.0842	2	0	0	12	0	0	0
A-F	-20.6933	6.7174	-33.485	-47.4609	32	2	0	1286	0	5	3
A-G	-366.0247	-95.588	-786.624	-1248.2367	262	80	14	31125	10	73	80
B-C	-362.8377	-101.4895	-789.795	-1254.1222	260	68	15	30767	9	73	79
B-D	-20.3852	6.6872	-34.8257	-48.5237	35	0	0	1327	0	5	2
B-F	0.0	0.0	-0.0007	-0.0007	2	0	0	2	0	0	0
B-G	-19.0067	6.5487	-34.6659	-47.1239	31	2	0	1348	0	6	3
C-D	-319.1636	-90.7783	-800.868	-1210.8099	262	72	13	31053	10	74	79
C-E	-22.0765	6.6373	-30.5122	-45.9514	31	2	0	1237	0	4	3
C-G	0.0	0.0	-0.0231	-0.0231	2	0	0	6	0	0	0
D-E	-329.3939	-99.855	-764.524	-1193.7728	254	68	15	30363	10	73	80
D-F	-12.6424	6.6935	-30.5314	-36.4803	31	1	0	1149	0	6	3
D-G	0.0	0.0	-0.1813	-0.1813	2	0	0	20	0	0	0
E-F	-312.2006	-95.941	-806.15	-1214.2916	254	73	13	31007	8	73	79
E-G	-11.8272	6.5882	-37.5807	-42.8196	34	2	0	1440	0	7	3
F-G	-310.3071	-94.46	-789.921	-1194.6881	263	73	14	30691	9	74	79

Interface residues

• A-B: ALA138A, ALA138B, ALA1A, ALA1B, ALA216B, ALA229B, ALA62B, ALA83A, ALA96A, ARG104A, ARG104B, ARG184A, ARG236A, ARG251B, ARG56B, ASN105A, ASN121A, ASN121B, ASN123A, ASN123B, ASN139A, ASN139B, ASN172A, ASN172B, ASN173A, ASN173B, ASN176B, ASN178B, ASN17B, ASN193A, ASN214B, ASN293B, ASN47A, ASN49A, ASN6A, ASP100A, ASP100B, ASP108A, ASP127A, ASP127B, ASP128A, ASP13A, ASP13B, ASP152B, ASP162A, ASP183A, ASP185A, ASP212B, ASP227B, ASP24B, ASP272A, ASP29B, ASP2A, ASP2B, ASP45A, ASP45B, ASP4A, ASP92A, GLN150A, GLN150B, GLN177B, GLN64B, GLN97A, GLU111A, GLU111B, GLU158A, GLU289B, GLU290B, GLY10A, GLY10B, GLY119A, GLY119B, GLY122A, GLY122B, GLY126A, GLY126B, GLY130A, GLY130B, GLY133A, GLY133B, GLY134A, GLY134B, GLY137A, GLY137B, GLY143A, GLY143B, GLY15A, GLY15B, GLY166A, GLY180B, GLY223B, GLY23B, GLY33B, GLY59B, GLY63B, HIS144A, HIS144B, HIS35B, HIS48A, HIS48B, ILE107A, ILE132B, ILE136A, ILE136B, ILE142A, ILE142B, ILE14A, ILE14B, ILE156A, ILE170A, ILE170B, ILE232A, ILE232B, ILE43B, ILE55B, ILE5A, ILE61B, ILE7A, ILE98A, LEU116A, LEU116B, LEU135A, LEU135B, LEU146A, LEU146B, LEU157A, LEU211B, LEU219B, LEU220B, LEU25B, LEU52A, LEU52B, LEU53B, LYS110A, LYS131A, LYS131B, LYS147A, LYS147B, LYS154A, LYS154B, LYS163A, LYS164A, LYS168A, LYS198B, LYS215B, LYS21B, LYS271A, LYS30B, LYS36B, LYS37B, LYS46A, LYS50A, LYS51A, LYS58B, LYS85A, LYS8A, MET174B, MET234A, MET291B, MET34B, PHE113A, PHE113B, PHE120A, PHE120B, PHE153B, PHE171A, PHE171B, PHE224B, PHE228B, PHE39B, PHE42B, PHE84B, PRO103A, PRO103B, PRO151B, PRO160A, PRO181A, PRO181B, PRO213B, PRO226B, SER106A, SER114A, SER141A, SER141B, SER159A, SER16A, SER16B, SER186A, SER217B, SER218B, SER221B, SER222B, SER225B, SER3A, SER41B, SER82A, SER99A, SER99B, THR109A, THR115A, THR115B, THR117A, THR117B, THR11A, THR125A, THR125B, THR129A, THR129B, THR12A, THR12B, THR145A, THR145B, THR155A, THR155B, THR161A, THR18B, THR199B, THR19B, THR22B, THR230B, THR233A, THR27B, THR292B, THR60B, THR9A, THR9B, TRP167A, TRP167B, TRP179B, TYR101A, TYR101B, TYR102A, TYR102B, TYR112A, TYR112B, TYR118A, TYR148A, TYR148B, TYR182A, TYR182B, TYR249B, TYR28B, TYR40B, VAL124A, VAL124B, VAL140A, VAL140B, VAL149B, VAL165A, VAL169A, VAL169B, VAL175B, VAL20B, VAL231A, VAL231B, VAL26B, VAL38B, VAL54B
• A-C: ALA229C, ARG56C, ASN178C, ASN6A, ASP227C, ASP24C, ASP2A, ASP4A, GLN177C, GLY180C, HIS144A, ILE142A, ILE5A, ILE7A, LEU116A, LEU146A, LYS147C, LYS37C, LYS58C, PHE113A, PHE39C, PRO181C, SER114A, SER3A, SER41C, THR115A, THR22C, TRP179C, TYR112A, TYR40C, VAL175C, VAL54C
• A-D: TRP179D, TYR118A
• A-F: ALA229A, ARG56A, ASN178A, ASN6F, ASP227A, ASP24A, ASP2F, ASP4F, GLN177A, GLY180A, HIS144F, ILE142F, ILE5F, ILE7F, LEU116F, LEU146F, LYS147A, LYS37A, LYS58A, PHE113F, PHE39A, PRO181A, SER114F, SER3F, SER41A, THR115F, THR22A, TRP179A, TYR112F, TYR40A, VAL175A, VAL54A
• A-G: ALA138A, ALA138G, ALA1G, ALA216A, ALA229A, ALA62A, ALA83G, ALA96G, ARG104A, ARG104G, ARG184G, ARG236G, ARG251A, ARG56A, ARG66A, ASN105G, ASN121A, ASN121G, ASN123A, ASN123G, ASN139A, ASN139G, ASN172A, ASN172G, ASN173A, ASN173G, ASN176A, ASN178A, ASN17A, ASN193G, ASN214A, ASN293A, ASN47G, ASN49G, ASN6G, ASP100A, ASP100G, ASP108G, ASP127A, ASP127G, ASP128G, ASP13A, ASP13G, ASP152A, ASP162G, ASP183G, ASP185G, ASP212A, ASP227A, ASP235G, ASP24A, ASP272G, ASP29A, ASP2A, ASP2G, ASP45A, ASP45G, ASP4G, GLN150A, GLN150G, GLN177A, GLN64A, GLN97G, GLU111A, GLU111G, GLU158G, GLU289A, GLU290A, GLY10A, GLY10G, GLY119A, GLY119G, GLY122A, GLY122G, GLY126A, GLY126G, GLY130A, GLY130G, GLY133A, GLY133G, GLY134A, GLY134G, GLY137A, GLY137G, GLY143A, GLY143G, GLY15A, GLY15G, GLY166G, GLY180A, GLY180G, GLY223A, GLY23A, GLY33A, GLY59A, GLY63A, HIS144A, HIS144G, HIS35A, HIS48A, HIS48G, ILE107G, ILE132A, ILE132G, ILE136A, ILE136G, ILE142A, ILE142G, ILE14A, ILE14G, ILE156G, ILE170A, ILE170G, ILE232A, ILE232G, ILE43A, ILE55A, ILE5G, ILE61A, ILE7G, ILE98G, LEU116A, LEU116G, LEU135A, LEU135G, LEU146A, LEU146G, LEU157G, LEU211A, LEU219A, LEU220A, LEU25A, LEU52A, LEU52G, LEU53A, LYS110G, LYS131A, LYS131G, LYS147A, LYS147G, LYS154A, LYS154G, LYS163G, LYS164G, LYS168G, LYS198A, LYS215A, LYS21A, LYS271G, LYS30A, LYS36A, LYS37A, LYS46G, LYS50G, LYS51G, LYS58A, LYS85G, LYS8G, MET174A, MET234G, MET291A, MET34A, PHE113A, PHE113G, PHE120A, PHE120G, PHE153A, PHE171A, PHE171G, PHE224A, PHE228A, PHE39A, PHE42A, PHE84A, PRO103A, PRO103G, PRO151A, PRO160G, PRO181A, PRO181G, PRO213A, PRO226A, SER106G, SER114A, SER114G, SER141A, SER141G, SER159G, SER16A, SER16G, SER186G, SER217A, SER218A, SER221A, SER222A, SER225A, SER3G, SER41A, SER82G, SER99A, SER99G, THR109G, THR115A, THR115G, THR117A, THR117G, THR11A, THR11G, THR125A, THR125G, THR129A, THR129G, THR12A, THR12G, THR145A, THR145G, THR155A, THR155G, THR161G, THR18A, THR199A, THR19A, THR22A, THR230A, THR233G, THR27A, THR292A, THR60A, THR9A, THR9G, TRP167A, TRP167G, TRP179A, TYR101A, TYR101G, TYR102A, TYR102G, TYR112A, TYR112G, TYR118A, TYR118G, TYR148A, TYR148G, TYR182A, TYR182G, TYR249A, TYR28A, TYR40A, VAL124A, VAL124G, VAL140A, VAL140G, VAL149A, VAL165G, VAL169A, VAL175A, VAL20A, VAL231A, VAL231G, VAL26A, VAL38A, VAL54A
• B-C: ALA138B, ALA138C, ALA1B, ALA216C, ALA229C, ALA62C, ALA83B, ALA96B, ARG104B, ARG104C, ARG184B, ARG236B, ARG251C, ARG56C, ARG66C, ASN105B, ASN121B, ASN121C, ASN123B, ASN123C, ASN139B, ASN139C, ASN172B, ASN172C, ASN173B, ASN173C, ASN176C, ASN178C, ASN17C, ASN193B, ASN214C, ASN293C, ASN47B, ASN49B, ASN6B, ASP100B, ASP100C, ASP108B, ASP127B, ASP127C, ASP128B, ASP13B, ASP13C, ASP152C, ASP162B, ASP183B, ASP183C, ASP185B, ASP212C, ASP227C, ASP235B, ASP24C, ASP272B, ASP29C, ASP2B, ASP2C, ASP45B, ASP45C, ASP4B, ASP92B, GLN150B, GLN150C, GLN177C, GLN64C, GLN97B, GLU111B, GLU111C, GLU158B, GLU289C, GLU290C, GLY10B, GLY10C, GLY119B, GLY119C, GLY122B, GLY122C, GLY126B, GLY126C, GLY130B, GLY130C, GLY133B, GLY133C, GLY134B, GLY134C, GLY137B, GLY137C, GLY143B, GLY143C, GLY15B, GLY15C, GLY166B, GLY180B, GLY180C, GLY223C, GLY23C, GLY33C, GLY59C, GLY63C, HIS144B, HIS144C, HIS35C, HIS48B, HIS48C, ILE107B, ILE132B, ILE132C, ILE136B, ILE136C, ILE142C, ILE14B, ILE14C, ILE156B, ILE170B, ILE170C, ILE232B, ILE232C, ILE43C, ILE55C, ILE5B, ILE61C, ILE7B, ILE98B, LEU116B, LEU116C, LEU135B, LEU135C, LEU146B, LEU146C, LEU157B, LEU211C, LEU219C, LEU220C, LEU25C, LEU52B, LEU52C, LEU53C, LYS110B, LYS131B, LYS131C, LYS147B, LYS147C, LYS154B, LYS154C, LYS163B, LYS164B, LYS168B, LYS198C, LYS215C, LYS21C, LYS271B, LYS30C, LYS36C, LYS37C, LYS46B, LYS50B, LYS51B, LYS58C, LYS8B, LYS8C, MET174C, MET234B, MET291C, MET34C, PHE113B, PHE113C, PHE120B, PHE153C, PHE171B, PHE171C, PHE224C, PHE228C, PHE39C, PHE42C, PHE84C, PRO103B, PRO103C, PRO151C, PRO160B, PRO181B, PRO181C, PRO213C, PRO226C, SER106B, SER114B, SER141B, SER141C, SER159B, SER16B, SER16C, SER186B, SER217C, SER218C, SER221C, SER222C, SER225C, SER3B, SER41C, SER82B, SER99B, SER99C, THR109B, THR115B, THR115C, THR117B, THR117C, THR11B, THR11C, THR125B, THR125C, THR129B, THR129C, THR12B, THR12C, THR145B, THR145C, THR155B, THR155C, THR161B, THR18C, THR19C, THR22C, THR230C, THR233B, THR27C, THR292C, THR60C, THR9B, THR9C, TRP167B, TRP167C, TRP179C, TYR101B, TYR101C, TYR102B, TYR102C, TYR112B, TYR112C, TYR118B, TYR118C, TYR148B, TYR148C, TYR182B, TYR182C, TYR249C, TYR28C, TYR40C, VAL124B, VAL124C, VAL140B, VAL140C, VAL149C, VAL165B, VAL169C, VAL175C, VAL20C, VAL231B, VAL231C, VAL26C, VAL38C, VAL54C
• B-D: ALA229D, ARG56D, ASN178D, ASN188D, ASN6B, ASP227D, ASP24D, ASP2B, ASP4B, GLN177D, GLY180D, HIS144B, ILE142B, ILE5B, ILE7B, LEU116B, LYS147D, LYS37D, LYS58D, LYS8B, PHE113B, PHE39D, PRO181D, SER114B, SER3B, SER41D, THR115B, THR22D, TRP179D, TYR112B, TYR118B, TYR40D, VAL175D, VAL20D, VAL54D
• B-F: TRP179B, TYR118F
• B-G: ALA229B, ARG56B, ASN178B, ASN6G, ASP227B, ASP24B, ASP2G, ASP4G, GLN177B, GLY180B, HIS144G, ILE142G, ILE5G, ILE7G, LEU116G, LYS147B, LYS37B, LYS58B, PHE113G, PHE39B, PRO181B, SER114G, SER3G, SER41B, THR115G, THR22B, TRP179B, TYR112G, TYR40B, VAL175B, VAL54B
• C-D: ALA138C, ALA138D, ALA1C, ALA1D, ALA216D, ALA229D, ALA62D, ALA83C, ARG104C, ARG104D, ARG184C, ARG236C, ARG251D, ARG56D, ASN105C, ASN121C, ASN121D, ASN123C, ASN123D, ASN139C, ASN139D, ASN172C, ASN172D, ASN173C, ASN173D, ASN176D, ASN178D, ASN17C, ASN17D, ASN193C, ASN214D, ASN293D, ASN47C, ASN49C, ASN6C, ASP100C, ASP100D, ASP108C, ASP127C, ASP127D, ASP128C, ASP13C, ASP13D, ASP152D, ASP162C, ASP183C, ASP185C, ASP212D, ASP227D, ASP24D, ASP272C, ASP29D, ASP2C, ASP2D, ASP45C, ASP45D, ASP4C, ASP92C, GLN150C, GLN150D, GLN177D, GLN64D, GLN97C, GLU111C, GLU111D, GLU158C, GLU289D, GLU290D, GLY10C, GLY10D, GLY119C, GLY119D, GLY122C, GLY122D, GLY126C, GLY126D, GLY130C, GLY130D, GLY133C, GLY133D, GLY134C, GLY134D, GLY137C, GLY137D, GLY143C, GLY143D, GLY15C, GLY15D, GLY166C, GLY180C, GLY180D, GLY223D, GLY23D, GLY33D, GLY59D, GLY63D, HIS144C, HIS144D, HIS35D, HIS48C, HIS48D, ILE107C, ILE132C, ILE132D, ILE136D, ILE142D, ILE14C, ILE14D, ILE156C, ILE170C, ILE170D, ILE232C, ILE232D, ILE43D, ILE55D, ILE5C, ILE61D, ILE7C, ILE98C, LEU116C, LEU116D, LEU135C, LEU135D, LEU146C, LEU146D, LEU157C, LEU211D, LEU219D, LEU220D, LEU25D, LEU52C, LEU52D, LEU53D, LYS110C, LYS110D, LYS131C, LYS131D, LYS147C, LYS147D, LYS154C, LYS154D, LYS163C, LYS164C, LYS168C, LYS198D, LYS215D, LYS21D, LYS271C, LYS30D, LYS36D, LYS37D, LYS46C, LYS50C, LYS51C, LYS58D, LYS85C, LYS8C, MET174D, MET234C, MET291D, MET34D, PHE113C, PHE113D, PHE120C, PHE120D, PHE153D, PHE171C, PHE171D, PHE224D, PHE228D, PHE39D, PHE42D, PHE84D, PRO103C, PRO103D, PRO151D, PRO160C, PRO181C, PRO181D, PRO213D, PRO226D, SER106C, SER114C, SER114D, SER141C, SER141D, SER159C, SER16C, SER16D, SER186C, SER217D, SER218D, SER221D, SER222D, SER225D, SER3C, SER41D, SER82C, SER99C, SER99D, THR109C, THR115C, THR115D, THR117C, THR117D, THR11C, THR125C, THR125D, THR129C, THR129D, THR12C, THR12D, THR145C, THR145D, THR155C, THR155D, THR161C, THR18D, THR199D, THR19D, THR22D, THR230D, THR233C, THR233D, THR27D, THR292D, THR60D, THR9C, THR9D, TRP167C, TRP167D, TRP179D, TYR101C, TYR101D, TYR102C, TYR102D, TYR112C, TYR112D, TYR118C, TYR118D, TYR148C, TYR148D, TYR182C, TYR182D, TYR249D, TYR28D, TYR40D, TYR65D, VAL124C, VAL124D, VAL140C, VAL140D, VAL149D, VAL165C, VAL169D, VAL175D, VAL20D, VAL231C, VAL231D, VAL26D, VAL38D, VAL54D
• C-E: ALA229E, ARG56E, ASN178E, ASN6C, ASP227E, ASP24E, ASP2C, ASP4C, GLN177E, GLY180E, HIS144C, ILE142C, ILE5C, ILE7C, LEU116C, LYS147E, LYS37E, LYS58E, PHE113C, PHE39E, PRO181E, SER114C, SER3C, SER41E, THR115C, THR22E, TRP179E, TYR112C, TYR40E, VAL175E, VAL54E
• C-G: TRP179C, TYR118G
• D-E: ALA138D, ALA138E, ALA1D, ALA216E, ALA229E, ALA62E, ALA83D, ALA96D, ARG104D, ARG104E, ARG184D, ARG236D, ARG251E, ARG56E, ASN105D, ASN121D, ASN121E, ASN123D, ASN123E, ASN139D, ASN139E, ASN172D, ASN172E, ASN173D, ASN173E, ASN176E, ASN178E, ASN17E, ASN214E, ASN293E, ASN47D, ASN49D, ASN6D, ASP100D, ASP100E, ASP108D, ASP127D, ASP127E, ASP128D, ASP13D, ASP13E, ASP152E, ASP162D, ASP183D, ASP185D, ASP212E, ASP227E, ASP24E, ASP272D, ASP29E, ASP2D, ASP2E, ASP45D, ASP45E, ASP4D, ASP92D, GLN150D, GLN150E, GLN177E, GLN64E, GLN97D, GLU111D, GLU111E, GLU158D, GLU289E, GLU290E, GLY10D, GLY10E, GLY119D, GLY119E, GLY122D, GLY126D, GLY130D, GLY130E, GLY133D, GLY133E, GLY134D, GLY134E, GLY137D, GLY137E, GLY143D, GLY143E, GLY15D, GLY15E, GLY166D, GLY180D, GLY180E, GLY223E, GLY23E, GLY33E, GLY59E, GLY63E, HIS144D, HIS144E, HIS35E, HIS48D, HIS48E, ILE107D, ILE132D, ILE132E, ILE136D, ILE136E, ILE142E, ILE14D, ILE14E, ILE156D, ILE170D, ILE170E, ILE232D, ILE232E, ILE43E, ILE55E, ILE5D, ILE61E, ILE7D, ILE98D, LEU116D, LEU116E, LEU135D, LEU135E, LEU146D, LEU146E, LEU157D, LEU211E, LEU219E, LEU220E, LEU25E, LEU52D, LEU52E, LEU53E, LYS110D, LYS131D, LYS131E, LYS147D, LYS147E, LYS154D, LYS154E, LYS163D, LYS164D, LYS168D, LYS198E, LYS215E, LYS21E, LYS271D, LYS30E, LYS36E, LYS37E, LYS46D, LYS50D, LYS51D, LYS58E, LYS8D, MET174E, MET234D, MET291E, MET34E, PHE113D, PHE113E, PHE120D, PHE120E, PHE153E, PHE171D, PHE171E, PHE224E, PHE228E, PHE39E, PHE42E, PHE84E, PRO103D, PRO103E, PRO151E, PRO160D, PRO181D, PRO181E, PRO213E, PRO226E, SER106D, SER114D, SER114E, SER141D, SER141E, SER159D, SER16D, SER16E, SER186D, SER217E, SER218E, SER221E, SER222E, SER225E, SER3D, SER41E, SER82D, SER99D, SER99E, THR109D, THR115D, THR115E, THR117D, THR117E, THR11D, THR125D, THR125E, THR129D, THR129E, THR12D, THR12E, THR145D, THR145E, THR155D, THR155E, THR161D, THR18E, THR199E, THR19E, THR22E, THR230E, THR233D, THR27E, THR292E, THR60E, THR9D, TRP167D, TRP167E, TRP179E, TYR101D, TYR101E, TYR102D, TYR102E, TYR112D, TYR112E, TYR118D, TYR118E, TYR148D, TYR148E, TYR182E, TYR249E, TYR28E, TYR40E, TYR65E, VAL124D, VAL124E, VAL140D, VAL140E, VAL149E, VAL165D, VAL169E, VAL175E, VAL20E, VAL231D, VAL231E, VAL26E, VAL38E, VAL54E
• D-F: ALA229F, ARG200F, ARG56F, ASN178F, ASN6D, ASP227F, ASP24F, ASP2D, ASP4D, GLN177F, GLY180F, HIS144D, ILE142D, ILE5D, ILE7D, LYS147F, LYS37F, LYS58F, PHE113D, PHE39F, PRO181F, SER114D, SER3D, SER41F, THR115D, THR22F, TRP179F, TYR112D, TYR40F, VAL175F, VAL54F
• D-G: TRP179G, TYR118D
• E-F: ALA138E, ALA138F, ALA1E, ALA216F, ALA229F, ALA62F, ALA83E, ALA96E, ARG104E, ARG104F, ARG184E, ARG236E, ARG251F, ARG56F, ASN105E, ASN121E, ASN121F, ASN123E, ASN123F, ASN139E, ASN139F, ASN172E, ASN172F, ASN173E, ASN173F, ASN176F, ASN178F, ASN17F, ASN214F, ASN293F, ASN47E, ASN49E, ASN6E, ASP100E, ASP100F, ASP108E, ASP127E, ASP127F, ASP128E, ASP13E, ASP13F, ASP152F, ASP162E, ASP183E, ASP185E, ASP212F, ASP227F, ASP235E, ASP24F, ASP272E, ASP29F, ASP2E, ASP2F, ASP45E, ASP45F, ASP4E, ASP92E, GLN150E, GLN150F, GLN177F, GLN64F, GLN97E, GLU111E, GLU111F, GLU158E, GLU289F, GLU290F, GLY10E, GLY10F, GLY119E, GLY119F, GLY122E, GLY126E, GLY126F, GLY130E, GLY130F, GLY133E, GLY133F, GLY134E, GLY134F, GLY137E, GLY137F, GLY143E, GLY143F, GLY15E, GLY15F, GLY166E, GLY180F, GLY223F, GLY23F, GLY33F, GLY59F, GLY63F, HIS144E, HIS144F, HIS35F, HIS48E, HIS48F, ILE107E, ILE132F, ILE136F, ILE142E, ILE142F, ILE14E, ILE14F, ILE156E, ILE170E, ILE170F, ILE232E, ILE232F, ILE43F, ILE55F, ILE5E, ILE61F, ILE7E, ILE98E, LEU116E, LEU116F, LEU135E, LEU135F, LEU146E, LEU146F, LEU157E, LEU211F, LEU219F, LEU220F, LEU25F, LEU52E, LEU52F, LEU53F, LYS110E, LYS131E, LYS131F, LYS147E, LYS147F, LYS154E, LYS154F, LYS163E, LYS164E, LYS168E, LYS198F, LYS215F, LYS21F, LYS271E, LYS30F, LYS36F, LYS37F, LYS46E, LYS50E, LYS51E, LYS58F, LYS85E, LYS8E, MET174F, MET234E, MET291F, MET34F, PHE113E, PHE113F, PHE120E, PHE120F, PHE153F, PHE171E, PHE171F, PHE224F, PHE228F, PHE39F, PHE42F, PHE84F, PRO103E, PRO103F, PRO151F, PRO160E, PRO181E, PRO181F, PRO213F, PRO226F, SER106E, SER114E, SER114F, SER141E, SER141F, SER159E, SER16E, SER16F, SER186E, SER217F, SER218F, SER221F, SER222F, SER225F, SER3E, SER41F, SER82E, SER99E, SER99F, THR109E, THR115E, THR115F, THR117E, THR117F, THR11E, THR125E, THR125F, THR129E, THR129F, THR12E, THR12F, THR145E, THR145F, THR155E, THR155F, THR161E, THR18F, THR19F, THR22F, THR230F, THR233E, THR27F, THR292F, THR60F, THR9E, THR9F, TRP167E, TRP179F, TYR101E, TYR101F, TYR102E, TYR102F, TYR112E, TYR112F, TYR118E, TYR118F, TYR148E, TYR148F, TYR182F, TYR249F, TYR28F, TYR40F, TYR65F, VAL124E, VAL124F, VAL140E, VAL140F, VAL149F, VAL165E, VAL169F, VAL175F, VAL20F, VAL231E, VAL231F, VAL26F, VAL38F, VAL54F
• E-G: ALA229G, ARG200G, ARG56G, ASN178G, ASN188G, ASN6E, ASP227G, ASP24G, ASP2E, ASP4E, GLN177G, GLY180G, HIS144E, ILE142E, ILE5E, ILE7E, LEU116E, LYS147G, LYS37G, LYS58G, PHE113E, PHE39G, PRO181G, SER114E, SER3E, SER41G, THR115E, THR22G, TRP179G, TYR112E, TYR118E, TYR40G, VAL175G, VAL54G
• F-G: ALA138F, ALA138G, ALA1F, ALA1G, ALA216G, ALA229G, ALA62G, ALA83F, ALA96F, ARG104F, ARG104G, ARG184F, ARG236F, ARG251G, ARG56G, ASN105F, ASN121F, ASN121G, ASN123F, ASN123G, ASN139F, ASN139G, ASN172F, ASN172G, ASN173F, ASN173G, ASN176G, ASN178G, ASN17F, ASN17G, ASN193F, ASN214G, ASN293G, ASN47F, ASN49F, ASN6F, ASP100F, ASP100G, ASP108F, ASP127F, ASP127G, ASP128F, ASP13F, ASP13G, ASP152G, ASP162F, ASP183F, ASP185F, ASP212G, ASP227G, ASP24G, ASP272F, ASP29G, ASP2F, ASP2G, ASP45F, ASP45G, ASP4F, GLN150F, GLN150G, GLN177G, GLN64G, GLN97F, GLU111F, GLU111G, GLU158F, GLU289G, GLU290G, GLY10F, GLY10G, GLY119F, GLY119G, GLY122F, GLY126F, GLY126G, GLY130F, GLY130G, GLY133F, GLY133G, GLY134F, GLY134G, GLY137F, GLY137G, GLY143F, GLY143G, GLY15F, GLY15G, GLY166F, GLY180F, GLY180G, GLY223G, GLY23G, GLY33G, GLY59G, GLY63G, HIS144F, HIS144G, HIS35G, HIS48F, HIS48G, ILE107F, ILE132F, ILE132G, ILE136F, ILE136G, ILE142F, ILE142G, ILE14F, ILE14G, ILE156F, ILE170F, ILE170G, ILE232F, ILE232G, ILE43G, ILE55G, ILE5F, ILE61G, ILE7F, ILE98F, LEU116F, LEU116G, LEU135F, LEU135G, LEU146F, LEU146G, LEU157F, LEU211G, LEU219G, LEU220G, LEU25G, LEU52F, LEU52G, LEU53G, LYS110F, LYS131F, LYS131G, LYS147F, LYS147G, LYS154F, LYS154G, LYS163F, LYS164F, LYS168F, LYS198G, LYS215G, LYS21G, LYS271F, LYS30G, LYS36G, LYS37G, LYS46F, LYS50F, LYS51F, LYS58G, LYS85F, LYS8F, MET174G, MET234F, MET291G, MET34G, PHE113F, PHE113G, PHE120F, PHE120G, PHE153G, PHE171F, PHE171G, PHE224G, PHE228G, PHE39G, PHE42G, PHE84G, PRO103F, PRO103G, PRO151G, PRO160F, PRO181F, PRO181G, PRO213G, PRO226G, SER106F, SER114F, SER141F, SER141G, SER159F, SER16F, SER16G, SER186F, SER217G, SER218G, SER221G, SER222G, SER225G, SER3F, SER41G, SER82F, SER99F, SER99G, THR109F, THR115F, THR115G, THR117F, THR117G, THR11F, THR11G, THR125F, THR125G, THR129F, THR129G, THR12F, THR12G, THR145F, THR145G, THR155F, THR155G, THR161F, THR18G, THR199G, THR19G, THR22G, THR230G, THR233F, THR27G, THR292G, THR60G, THR9F, THR9G, TRP167F, TRP167G, TRP179G, TYR101F, TYR101G, TYR102F, TYR102G, TYR112F, TYR112G, TYR118F, TYR118G, TYR148F, TYR148G, TYR182F, TYR182G, TYR249G, TYR28G, TYR40G, TYR65G, VAL124F, VAL124G, VAL140F, VAL140G, VAL149G, VAL165F, VAL169F, VAL169G, VAL175G, VAL20G, VAL231F, VAL231G, VAL26G, VAL38G, VAL54G, VAL95F