3M1A

the crystal structure of a short-chain dehydrogenase from streptomyces avermitilis to 2a

• Total interactions analyzed: 45
• Total true interactions: 20
• Strongest Interaction:
  • Chains: A-B
  • Int. Res.: 312
  • Norm. En. per Res.: -5.5478
• Hub Node: A(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-320.8529	-319.3386	-1090.72	-1730.9115	312	47	29	40607	28	102	96
A-C	-100.7478	-111.5381	-294.839	-507.1249	121	13	5	10979	6	62	54
A-E	0.0	-25.466	-17.5227	-42.9887	14	2	0	630	2	9	8
A-F	0.0	15.3555	-29.7772	-14.4217	17	3	0	1118	2	12	11
B-C	-2.1836	13.8691	-29.6615	-17.976	16	2	0	1112	2	12	10
B-D	0.0	34.3528	-24.099	10.2538	20	0	0	1159	0	14	10
B-E	-93.127	-53.7328	-272.504	-419.3639	114	12	6	9908	3	58	42
C-F	-299.443	-315.817	-1016.93	-1632.19	312	51	28	39077	28	105	95
C-I	0.0	-18.6801	-13.6026	-32.2827	14	0	0	718	0	9	8
D-E	-295.3031	-313.3814	-1042.82	-1651.5044	310	50	29	39429	26	104	93
D-H	-109.0378	-91.1074	-302.212	-502.3571	124	28	5	11747	6	63	52
D-J	0.0	-33.0475	-20.8934	-53.9409	17	0	0	998	2	12	10
E-H	-18.5077	-25.5932	-20.218	-64.3189	15	4	0	944	1	10	9
F-G	0.0	-32.1546	-11.6391	-43.7937	19	0	0	666	0	14	11
F-I	-76.3836	-38.4367	-247.199	-362.0193	117	11	5	9034	3	59	49
G-H	0.0	-12.9953	-9.3085	-22.3038	15	2	0	807	0	14	8
G-I	-282.6418	-304.8689	-1020.46	-1607.9707	310	48	28	39257	29	101	94
G-J	-91.3536	-42.9955	-248.431	-382.7801	116	21	5	9622	4	58	50
H-J	-257.2812	-342.4899	-1000.6	-1600.3711	307	56	30	38500	29	104	96
I-J	-2.7724	-28.4033	-20.3989	-51.5746	17	1	0	1035	2	13	9

Interface residues

• A-B: ALA115A, ALA115B, ALA120A, ALA120B, ALA146A, ALA146B, ALA150A, ALA150B, ALA153A, ALA153B, ALA156A, ALA156B, ALA157A, ALA157B, ALA166A, ALA166B, ALA170A, ALA170B, ALA183A, ALA183B, ALA202A, ALA202B, ALA204A, ALA204B, ALA226A, ALA226B, ALA228A, ALA228B, ALA229A, ALA229B, ALA230A, ALA230B, ALA231A, ALA231B, ALA235A, ALA235B, ALA246A, ALA246B, ALA251A, ALA251B, ALA264A, ALA264B, ALA94A, ALA94B, ARG101A, ARG101B, ARG104A, ARG104B, ARG116A, ARG116B, ARG119A, ARG119B, ARG126A, ARG126B, ARG185A, ARG185B, ARG233A, ARG233B, ARG244A, ARG244B, ARG263A, ARG263B, ARG274A, ARG274B, ASN135A, ASN135B, ASN187A, ASN187B, ASN200A, ASN200B, ASN85A, ASP105A, ASP105B, ASP167A, ASP167B, ASP224A, ASP224B, ASP237A, ASP237B, ASP250A, ASP250B, ASP253A, ASP253B, ASP260A, ASP260B, ASP277A, ASP277B, ASP62A, ASP62B, GLN124A, GLN124B, GLN142A, GLN142B, GLN160A, GLN160B, GLN221B, GLN91A, GLU100A, GLU100B, GLU102A, GLU102B, GLU108A, GLU108B, GLU127B, GLU159A, GLU159B, GLU163A, GLU163B, GLU168A, GLU168B, GLU180A, GLU180B, GLU205A, GLU205B, GLU239A, GLU239B, GLU265A, GLU265B, GLU268A, GLU268B, GLU270A, GLU270B, GLU64A, GLU64B, GLU96A, GLU96B, GLU97A, GLU97B, GLY113A, GLY113B, GLY140A, GLY140B, GLY141A, GLY141B, GLY147A, GLY147B, GLY164A, GLY164B, GLY182A, GLY182B, GLY223A, GLY223B, GLY248A, GLY248B, GLY249A, GLY249B, GLY257A, GLY257B, GLY275A, GLY275B, GLY63A, GLY63B, GLY93A, GLY93B, HIS258A, HIS258B, ILE174A, ILE174B, ILE178A, ILE178B, ILE232A, ILE232B, ILE66A, ILE66B, LEU103A, LEU103B, LEU106A, LEU106B, LEU117A, LEU117B, LEU121A, LEU121B, LEU122A, LEU122B, LEU143A, LEU143B, LEU158A, LEU158B, LEU161A, LEU161B, LEU165A, LEU165B, LEU177A, LEU177B, LEU188B, LEU234A, LEU234B, LEU236A, LEU236B, LEU243A, LEU243B, LEU245A, LEU245B, LEU247A, LEU247B, LEU255A, LEU255B, LEU259A, LEU259B, LEU266A, LEU266B, LEU83B, LYS155A, LYS155B, LYS206A, LYS206B, LYS227A, LYS227B, LYS240A, LYS240B, LYS271A, LYS271B, PHE107A, PHE107B, PHE112A, PHE112B, PHE139A, PHE139B, PHE145A, PHE145B, PHE148A, PHE148B, PHE172A, PHE172B, PHE17A, PHE17B, PHE184A, PHE184B, PHE189B, PHE254A, PHE254B, PHE278A, PHE278B, PHE95A, PHE95B, PRO114A, PRO114B, PRO123A, PRO123B, PRO171A, PRO171B, PRO181A, PRO181B, PRO201A, PRO201B, PRO222A, PRO222B, PRO225A, PRO225B, PRO242A, PRO242B, SER144A, SER144B, SER149A, SER149B, SER152A, SER152B, SER162A, SER162B, SER261A, SER261B, SER273A, SER273B, THR118A, THR118B, THR154A, THR154B, THR186A, THR210A, THR210B, THR238A, THR238B, THR241A, THR241B, THR256A, THR256B, THR267A, THR267B, THR276A, THR276B, THR61A, THR61B, THR98A, THR98B, THR99A, THR99B, TRP269A, TRP269B, TYR151A, TYR151B, TYR203A, TYR203B, VAL111A, VAL111B, VAL133A, VAL133B, VAL169A, VAL169B, VAL179A, VAL179B, VAL207A, VAL207B, VAL252A, VAL252B, VAL262A, VAL262B, VAL272A, VAL272B, VAL60A, VAL60B, VAL92A, VAL92B
• A-C: ALA13A, ALA13C, ALA193A, ALA193C, ALA194A, ALA194C, ALA202A, ALA202C, ALA204A, ALA204C, ALA36A, ALA36C, ALA41A, ALA41C, ALA87A, ALA87C, ALA94A, ALA94C, ARG101A, ARG101C, ARG19A, ARG19C, ARG211A, ARG211C, ARG37A, ARG37C, ARG38A, ARG38C, ARG89A, ARG89C, ASN187A, ASN187C, ASN200A, ASN200C, ASN86A, ASN86C, ASP105A, ASP43A, ASP43C, ASP44A, ASP44C, ASP59A, GLN212A, GLN212C, GLN215A, GLN215C, GLN91A, GLN91C, GLU100A, GLU100C, GLU102A, GLU102C, GLU198A, GLU198C, GLU199A, GLU199C, GLU205A, GLU205C, GLU40A, GLU40C, GLU96A, GLU96C, GLU97A, GLU97C, GLY12A, GLY12C, GLY16A, GLY16C, GLY190A, GLY190C, GLY192A, GLY192C, GLY208A, GLY208C, GLY216A, GLY216C, GLY88A, GLY88C, LEU109A, LEU109C, LEU188A, LEU188C, LEU42A, LEU42C, LEU45A, LEU45C, LYS191A, LYS191C, PHE189A, PHE189C, PHE196A, PHE196C, PHE95A, PHE95C, PRO201A, PRO201C, SER14A, SER14C, SER15A, SER15C, SER197A, SER197C, THR186A, THR186C, THR35A, THR90A, THR90C, THR98A, THR98C, THR99A, THR99C, TYR195A, TYR195C, TYR203A, TYR203C, VAL207A, VAL207C, VAL214A, VAL214C, VAL92A, VAL92C
• A-E: ALA41E, ALA47E, ARG119A, ARG126A, ARG38E, ASP43E, GLU127A, GLU40E, LEU122A, LEU42E, PHE172A, PRO123A, THR39E, VAL169A
• A-F: ALA120F, ALA41A, ALA47A, ARG119F, ARG126F, ARG37A, ARG38A, ASP43A, ASP44A, GLN124F, GLU127F, GLU40A, LEU122F, LEU42A, PHE172F, PRO123F, THR39A
• B-C: ALA120B, ALA41C, ALA47C, ARG119B, ARG126B, ARG38C, ASP43C, ASP44C, GLN124B, GLU127B, GLU40C, LEU122B, LEU42C, PHE172B, PRO123B, THR39C
• B-D: ALA120D, ALA41B, ALA47B, ALA71D, ARG119D, ARG126D, ARG19B, ARG37B, ARG38B, ASP43B, ASP44B, GLN124D, GLU127D, GLU40B, LEU121D, LEU122D, LEU42B, LEU74D, PRO123D, THR39B
• B-E: ALA13E, ALA193B, ALA193E, ALA194B, ALA194E, ALA202B, ALA202E, ALA204B, ALA204E, ALA36B, ALA36E, ALA41B, ALA41E, ALA87B, ALA87E, ALA94B, ALA94E, ARG101B, ARG101E, ARG185B, ARG19B, ARG19E, ARG211B, ARG211E, ARG37B, ARG37E, ARG38B, ARG38E, ARG89B, ARG89E, ASN187B, ASN187E, ASN200B, ASN200E, ASN86E, ASP105E, ASP44B, ASP44E, ASP59E, GLN212B, GLN212E, GLN215B, GLN215E, GLN221B, GLN221E, GLN91B, GLN91E, GLU102B, GLU102E, GLU198B, GLU198E, GLU199B, GLU199E, GLU205E, GLU23B, GLU23E, GLU40B, GLU40E, GLU96B, GLU96E, GLU97B, GLU97E, GLY12B, GLY12E, GLY16B, GLY16E, GLY190B, GLY190E, GLY192B, GLY192E, GLY208B, GLY208E, GLY216B, GLY88B, GLY88E, LEU109E, LEU188B, LEU188E, LEU42B, LEU42E, LYS191B, LYS191E, PHE189B, PHE189E, PHE196B, PHE196E, PHE95B, PHE95E, PRO201B, PRO201E, SER14B, SER14E, SER15B, SER15E, SER197B, SER197E, THR186B, THR186E, THR61E, THR90B, THR90E, THR98B, THR98E, THR99B, THR99E, TYR195B, TYR195E, TYR203B, TYR203E, VAL207B, VAL214B, VAL214E, VAL92B, VAL92E
• C-F: ALA115C, ALA115F, ALA120C, ALA120F, ALA146C, ALA146F, ALA150C, ALA150F, ALA153C, ALA153F, ALA156C, ALA156F, ALA157C, ALA157F, ALA166C, ALA166F, ALA170C, ALA170F, ALA183C, ALA183F, ALA202C, ALA202F, ALA204C, ALA204F, ALA226C, ALA226F, ALA228C, ALA228F, ALA229C, ALA229F, ALA230C, ALA230F, ALA231C, ALA231F, ALA235C, ALA235F, ALA246C, ALA246F, ALA251C, ALA251F, ALA264C, ALA264F, ALA94C, ALA94F, ARG101C, ARG101F, ARG104C, ARG104F, ARG116C, ARG116F, ARG119C, ARG119F, ARG126C, ARG126F, ARG185C, ARG185F, ARG233C, ARG233F, ARG244C, ARG244F, ARG263C, ARG263F, ARG274C, ARG274F, ASN135C, ASN135F, ASN187F, ASN200C, ASN200F, ASN85C, ASP105C, ASP105F, ASP167C, ASP167F, ASP224C, ASP224F, ASP237C, ASP237F, ASP250C, ASP250F, ASP253C, ASP253F, ASP260C, ASP260F, ASP277C, ASP277F, ASP62C, ASP62F, GLN124C, GLN124F, GLN142C, GLN142F, GLN160C, GLN160F, GLN221F, GLN91F, GLU100C, GLU100F, GLU102C, GLU102F, GLU108C, GLU108F, GLU127F, GLU159C, GLU159F, GLU163C, GLU163F, GLU168C, GLU168F, GLU180C, GLU180F, GLU205C, GLU205F, GLU239C, GLU239F, GLU265C, GLU265F, GLU268C, GLU268F, GLU270C, GLU270F, GLU64C, GLU64F, GLU96C, GLU96F, GLU97C, GLU97F, GLY113C, GLY113F, GLY140C, GLY140F, GLY141C, GLY141F, GLY147C, GLY147F, GLY164C, GLY164F, GLY182C, GLY182F, GLY223C, GLY223F, GLY248C, GLY248F, GLY249C, GLY249F, GLY257C, GLY257F, GLY275C, GLY275F, GLY63C, GLY63F, GLY93C, GLY93F, HIS258C, HIS258F, ILE174C, ILE174F, ILE178C, ILE178F, ILE232C, ILE232F, ILE66C, ILE66F, LEU103C, LEU103F, LEU106C, LEU106F, LEU117C, LEU117F, LEU121C, LEU121F, LEU122C, LEU122F, LEU143C, LEU143F, LEU158C, LEU158F, LEU161C, LEU161F, LEU165C, LEU165F, LEU177C, LEU177F, LEU188F, LEU234C, LEU234F, LEU236C, LEU236F, LEU243C, LEU243F, LEU245C, LEU245F, LEU247C, LEU247F, LEU255C, LEU255F, LEU259C, LEU259F, LEU266C, LEU266F, LEU83C, LEU83F, LYS155C, LYS155F, LYS206C, LYS206F, LYS227C, LYS227F, LYS240C, LYS240F, LYS271C, LYS271F, PHE107C, PHE107F, PHE112C, PHE112F, PHE139C, PHE139F, PHE145C, PHE145F, PHE148C, PHE148F, PHE172C, PHE172F, PHE17C, PHE17F, PHE184C, PHE184F, PHE189F, PHE254C, PHE254F, PHE278C, PHE95C, PHE95F, PRO114C, PRO114F, PRO123C, PRO123F, PRO171C, PRO171F, PRO181C, PRO181F, PRO201C, PRO201F, PRO222C, PRO222F, PRO225C, PRO225F, PRO242C, PRO242F, SER144C, SER144F, SER149C, SER149F, SER152C, SER152F, SER162C, SER162F, SER197C, SER261C, SER261F, SER273C, SER273F, THR118C, THR118F, THR154C, THR154F, THR186F, THR210C, THR210F, THR238C, THR238F, THR241C, THR241F, THR256C, THR256F, THR267C, THR267F, THR276C, THR276F, THR61C, THR61F, THR98C, THR98F, THR99C, THR99F, TRP269C, TRP269F, TYR151C, TYR151F, TYR203C, TYR203F, VAL111C, VAL111F, VAL133C, VAL133F, VAL169C, VAL169F, VAL179C, VAL179F, VAL207C, VAL207F, VAL252C, VAL252F, VAL262C, VAL262F, VAL272C, VAL272F, VAL60C, VAL60F, VAL92C, VAL92F
• C-I: ALA120C, ALA41I, ARG119C, ARG126C, ARG38I, ASP43I, ASP44I, GLN124C, GLU127C, GLU40I, LEU122C, LEU42I, PRO123C, THR39I
• D-E: ALA115D, ALA115E, ALA120D, ALA120E, ALA146D, ALA146E, ALA150D, ALA150E, ALA153D, ALA153E, ALA156D, ALA156E, ALA157D, ALA157E, ALA166D, ALA166E, ALA170D, ALA170E, ALA183D, ALA183E, ALA202D, ALA202E, ALA204D, ALA204E, ALA226D, ALA226E, ALA228D, ALA228E, ALA229D, ALA229E, ALA230D, ALA230E, ALA231D, ALA231E, ALA235D, ALA235E, ALA246D, ALA246E, ALA251D, ALA251E, ALA264D, ALA264E, ALA94D, ALA94E, ARG101D, ARG101E, ARG104D, ARG104E, ARG116D, ARG116E, ARG119D, ARG119E, ARG126D, ARG126E, ARG185D, ARG185E, ARG233D, ARG233E, ARG244D, ARG244E, ARG263D, ARG263E, ARG274D, ARG274E, ASN135D, ASN135E, ASN187D, ASN200D, ASN200E, ASN85D, ASN85E, ASP105D, ASP105E, ASP167D, ASP167E, ASP224D, ASP224E, ASP237D, ASP237E, ASP250D, ASP250E, ASP253D, ASP253E, ASP260D, ASP260E, ASP277D, ASP277E, ASP62D, ASP62E, GLN124D, GLN124E, GLN142D, GLN142E, GLN160D, GLN160E, GLN221D, GLN221E, GLU100D, GLU100E, GLU102D, GLU102E, GLU108D, GLU108E, GLU127D, GLU159D, GLU159E, GLU163D, GLU163E, GLU168D, GLU168E, GLU180D, GLU180E, GLU198E, GLU205D, GLU205E, GLU239D, GLU239E, GLU265D, GLU265E, GLU268D, GLU268E, GLU270D, GLU270E, GLU64D, GLU96D, GLU96E, GLU97D, GLU97E, GLY113D, GLY113E, GLY140D, GLY140E, GLY141D, GLY141E, GLY147D, GLY147E, GLY164D, GLY164E, GLY182D, GLY182E, GLY223D, GLY223E, GLY248D, GLY248E, GLY249D, GLY249E, GLY257D, GLY257E, GLY275D, GLY275E, GLY63D, GLY63E, GLY93D, GLY93E, HIS258D, HIS258E, ILE174D, ILE174E, ILE178D, ILE178E, ILE232D, ILE232E, ILE66D, ILE66E, LEU103D, LEU103E, LEU106D, LEU106E, LEU117D, LEU117E, LEU121D, LEU121E, LEU122D, LEU122E, LEU143D, LEU143E, LEU158D, LEU158E, LEU161D, LEU161E, LEU165D, LEU165E, LEU177D, LEU177E, LEU234D, LEU234E, LEU236D, LEU236E, LEU243D, LEU243E, LEU245D, LEU245E, LEU247D, LEU247E, LEU255D, LEU255E, LEU259D, LEU259E, LEU266D, LEU266E, LEU83D, LEU83E, LYS155D, LYS155E, LYS206D, LYS206E, LYS227D, LYS227E, LYS240D, LYS240E, LYS271D, LYS271E, PHE107D, PHE107E, PHE112D, PHE112E, PHE139D, PHE139E, PHE145D, PHE145E, PHE148D, PHE148E, PHE172D, PHE172E, PHE17D, PHE17E, PHE184D, PHE184E, PHE254D, PHE254E, PHE278E, PHE95D, PHE95E, PRO114D, PRO114E, PRO123D, PRO123E, PRO171D, PRO171E, PRO181D, PRO181E, PRO201D, PRO201E, PRO222D, PRO222E, PRO225D, PRO225E, PRO242D, PRO242E, SER144D, SER144E, SER149D, SER149E, SER152D, SER152E, SER162D, SER162E, SER197E, SER261D, SER261E, SER273D, SER273E, THR118D, THR118E, THR154D, THR154E, THR210D, THR210E, THR238D, THR238E, THR241D, THR241E, THR256D, THR256E, THR267D, THR267E, THR276D, THR276E, THR61D, THR61E, THR98D, THR98E, THR99D, THR99E, TRP269D, TRP269E, TYR151D, TYR151E, TYR203D, TYR203E, VAL111D, VAL111E, VAL133D, VAL133E, VAL169D, VAL169E, VAL179D, VAL179E, VAL207D, VAL207E, VAL252D, VAL252E, VAL262D, VAL262E, VAL272D, VAL272E, VAL60D, VAL60E, VAL92D, VAL92E
• D-H: ALA13D, ALA13H, ALA193D, ALA193H, ALA194D, ALA194H, ALA202D, ALA202H, ALA204D, ALA204H, ALA20D, ALA36D, ALA36H, ALA41D, ALA41H, ALA87H, ALA94D, ALA94H, ARG185D, ARG185H, ARG19D, ARG19H, ARG211D, ARG211H, ARG37D, ARG37H, ARG38D, ARG38H, ARG89D, ARG89H, ASN187D, ASN187H, ASN200D, ASN200H, ASN86D, ASP43D, ASP43H, ASP44D, ASP44H, GLN212D, GLN212H, GLN215D, GLN215H, GLN91D, GLN91H, GLU100D, GLU102D, GLU102H, GLU198D, GLU198H, GLU199D, GLU199H, GLU205D, GLU205H, GLU23D, GLU40D, GLU40H, GLU96D, GLU96H, GLU97D, GLU97H, GLY12D, GLY12H, GLY16D, GLY16H, GLY190D, GLY190H, GLY192D, GLY192H, GLY208D, GLY208H, GLY216D, GLY216H, GLY88D, GLY88H, LEU109H, LEU188D, LEU188H, LEU42D, LEU42H, LEU45D, LEU45H, LYS191D, LYS191H, PHE184D, PHE184H, PHE189D, PHE189H, PHE196D, PHE196H, PHE95D, PHE95H, PRO201D, PRO201H, PRO209D, PRO209H, SER14D, SER14H, SER15D, SER15H, SER197D, SER197H, SER217D, THR186D, THR186H, THR35D, THR39D, THR39H, THR90D, THR90H, THR98D, THR98H, THR99D, THR99H, TYR195D, TYR195H, TYR203D, TYR203H, VAL207D, VAL207H, VAL214D, VAL214H, VAL92D, VAL92H
• D-J: ALA120J, ALA41D, ALA47D, ARG119J, ARG126J, ARG38D, ASP43D, ASP44D, GLN124J, GLU127J, GLU40D, LEU122J, LEU42D, LEU74J, PHE172J, PRO123J, THR39D
• E-H: ALA120E, ALA41H, ALA47H, ARG119E, ARG126E, ARG38H, ASP43H, ASP44H, GLN124E, GLU127E, GLU40H, LEU122E, LEU42H, PRO123E, THR39H
• F-G: ALA120G, ALA41F, ALA47F, ARG119G, ARG126G, ARG19F, ARG37F, ARG38F, ASP43F, ASP44F, GLN124G, GLU127G, GLU40F, LEU121G, LEU122G, LEU42F, LEU74G, PRO123G, THR39F
• F-I: ALA13F, ALA13I, ALA193F, ALA193I, ALA194F, ALA194I, ALA202F, ALA202I, ALA204F, ALA204I, ALA36F, ALA36I, ALA41F, ALA41I, ALA87F, ALA87I, ALA94F, ARG101F, ARG101I, ARG185F, ARG19F, ARG19I, ARG211F, ARG211I, ARG37F, ARG37I, ARG38F, ARG38I, ARG89F, ARG89I, ASN187F, ASN187I, ASN200F, ASN200I, ASN86F, ASN86I, ASP105I, ASP43F, ASP43I, ASP44F, ASP44I, ASP59F, ASP59I, GLN212F, GLN212I, GLN215F, GLN215I, GLN221F, GLN91I, GLU100I, GLU102F, GLU102I, GLU198F, GLU198I, GLU199F, GLU199I, GLU205I, GLU23F, GLU40F, GLU40I, GLU96F, GLU96I, GLU97F, GLU97I, GLY12F, GLY12I, GLY16F, GLY16I, GLY190F, GLY190I, GLY192F, GLY192I, GLY208F, GLY208I, GLY88F, GLY88I, LEU106I, LEU109F, LEU109I, LEU188F, LEU188I, LEU42F, LEU42I, LEU45I, LYS191F, LYS191I, PHE189F, PHE189I, PHE196F, PHE196I, PHE95F, PRO201F, PRO201I, SER14F, SER14I, SER15F, SER15I, SER197F, SER197I, THR186F, THR186I, THR61I, THR90F, THR90I, THR98F, THR98I, THR99F, THR99I, TYR195F, TYR195I, TYR203F, TYR203I, VAL207F, VAL214F, VAL214I, VAL92F, VAL92I
• G-H: ALA120H, ALA41G, ALA47G, ARG119H, ARG126H, ARG37G, ARG38G, ASP43G, ASP44G, GLN124H, GLU127H, GLU40G, LEU122H, LEU42G, PRO123H
• G-I: ALA115G, ALA115I, ALA120G, ALA120I, ALA146G, ALA146I, ALA150G, ALA150I, ALA153G, ALA153I, ALA156G, ALA156I, ALA157G, ALA157I, ALA166G, ALA166I, ALA170G, ALA170I, ALA183G, ALA183I, ALA202G, ALA202I, ALA204G, ALA204I, ALA226G, ALA226I, ALA228G, ALA228I, ALA229G, ALA229I, ALA230G, ALA230I, ALA231G, ALA231I, ALA235G, ALA235I, ALA246G, ALA246I, ALA251G, ALA251I, ALA264G, ALA264I, ALA94G, ALA94I, ARG101G, ARG101I, ARG104G, ARG104I, ARG116G, ARG116I, ARG119G, ARG119I, ARG126G, ARG126I, ARG185G, ARG185I, ARG233G, ARG233I, ARG244G, ARG244I, ARG263G, ARG263I, ARG274G, ARG274I, ASN135G, ASN135I, ASN187G, ASN200G, ASN200I, ASN85G, ASN85I, ASP105G, ASP105I, ASP167G, ASP167I, ASP224G, ASP224I, ASP237G, ASP237I, ASP250G, ASP250I, ASP253G, ASP253I, ASP260G, ASP260I, ASP277G, ASP277I, ASP62G, ASP62I, GLN124G, GLN124I, GLN142G, GLN142I, GLN160G, GLN160I, GLN221G, GLN221I, GLU100G, GLU100I, GLU102G, GLU102I, GLU108G, GLU108I, GLU159G, GLU159I, GLU163G, GLU163I, GLU168G, GLU168I, GLU180G, GLU180I, GLU205G, GLU205I, GLU239G, GLU239I, GLU265G, GLU265I, GLU268G, GLU268I, GLU270G, GLU270I, GLU64G, GLU64I, GLU96G, GLU96I, GLU97G, GLU97I, GLY113G, GLY113I, GLY140G, GLY140I, GLY141G, GLY141I, GLY147G, GLY147I, GLY164G, GLY164I, GLY182G, GLY182I, GLY223G, GLY223I, GLY248G, GLY248I, GLY249G, GLY249I, GLY257G, GLY257I, GLY275G, GLY275I, GLY63G, GLY63I, GLY93G, GLY93I, HIS258G, HIS258I, ILE174G, ILE174I, ILE178G, ILE178I, ILE232G, ILE232I, ILE66G, ILE66I, LEU103G, LEU103I, LEU106G, LEU106I, LEU117G, LEU117I, LEU121G, LEU121I, LEU122G, LEU122I, LEU143G, LEU143I, LEU158G, LEU158I, LEU161G, LEU161I, LEU165G, LEU165I, LEU177G, LEU177I, LEU188G, LEU234G, LEU234I, LEU236G, LEU236I, LEU243G, LEU243I, LEU245G, LEU245I, LEU247G, LEU247I, LEU255G, LEU255I, LEU259G, LEU259I, LEU266G, LEU266I, LEU83I, LYS155G, LYS155I, LYS206G, LYS206I, LYS227G, LYS227I, LYS240G, LYS240I, LYS271G, LYS271I, PHE107G, PHE107I, PHE112G, PHE112I, PHE139G, PHE139I, PHE145G, PHE145I, PHE148G, PHE148I, PHE172G, PHE172I, PHE17G, PHE17I, PHE184G, PHE184I, PHE189G, PHE254G, PHE254I, PHE278I, PHE95G, PHE95I, PRO114G, PRO114I, PRO123G, PRO123I, PRO171G, PRO171I, PRO181G, PRO181I, PRO201G, PRO201I, PRO222G, PRO222I, PRO225G, PRO225I, PRO242G, PRO242I, SER144G, SER144I, SER149G, SER149I, SER152G, SER152I, SER162G, SER162I, SER197G, SER197I, SER261G, SER261I, SER273G, SER273I, THR118G, THR118I, THR154G, THR154I, THR186G, THR210G, THR210I, THR238G, THR238I, THR241G, THR241I, THR256G, THR256I, THR267G, THR267I, THR276G, THR276I, THR61G, THR61I, THR98G, THR98I, THR99G, THR99I, TRP269G, TRP269I, TYR151G, TYR151I, TYR203G, TYR203I, VAL111G, VAL111I, VAL133G, VAL133I, VAL169G, VAL169I, VAL179G, VAL207G, VAL207I, VAL252G, VAL252I, VAL262G, VAL262I, VAL272G, VAL272I, VAL60G, VAL60I, VAL92G
• G-J: ALA13G, ALA13J, ALA193G, ALA193J, ALA194G, ALA194J, ALA202G, ALA202J, ALA204G, ALA204J, ALA20G, ALA20J, ALA36G, ALA36J, ALA41G, ALA41J, ALA87J, ALA94G, ALA94J, ARG185G, ARG19G, ARG19J, ARG211G, ARG211J, ARG37G, ARG37J, ARG38G, ARG38J, ARG89G, ARG89J, ASN187G, ASN187J, ASN200G, ASN200J, ASN86J, ASP43J, ASP44G, ASP44J, GLN212G, GLN212J, GLN215G, GLN215J, GLN91J, GLU100G, GLU100J, GLU102G, GLU102J, GLU198G, GLU198J, GLU199G, GLU199J, GLU205G, GLU205J, GLU23G, GLU40G, GLU40J, GLU96G, GLU96J, GLU97G, GLU97J, GLY12J, GLY16G, GLY16J, GLY18J, GLY190G, GLY190J, GLY192G, GLY192J, GLY208G, GLY208J, GLY88G, GLY88J, LEU109J, LEU188G, LEU188J, LEU42G, LEU42J, LEU45G, LEU45J, LYS191G, LYS191J, PHE184G, PHE189G, PHE189J, PHE196G, PHE196J, PHE95G, PHE95J, PRO201G, PRO201J, PRO209G, PRO209J, SER14G, SER14J, SER15G, SER15J, SER197G, SER197J, THR186G, THR186J, THR90G, THR90J, THR98G, THR98J, THR99G, THR99J, TYR195G, TYR195J, TYR203G, TYR203J, VAL207G, VAL207J, VAL214G, VAL214J, VAL92G, VAL92J
• H-J: ALA115H, ALA115J, ALA120H, ALA120J, ALA146H, ALA146J, ALA150H, ALA150J, ALA153H, ALA153J, ALA156H, ALA156J, ALA157H, ALA157J, ALA166H, ALA166J, ALA170H, ALA170J, ALA183H, ALA183J, ALA202H, ALA202J, ALA204H, ALA204J, ALA226H, ALA226J, ALA228H, ALA228J, ALA229H, ALA229J, ALA230H, ALA230J, ALA231H, ALA231J, ALA235H, ALA235J, ALA246H, ALA246J, ALA251H, ALA251J, ALA264H, ALA264J, ALA94H, ALA94J, ARG101H, ARG101J, ARG104H, ARG104J, ARG116H, ARG116J, ARG119H, ARG119J, ARG126H, ARG126J, ARG185H, ARG185J, ARG233H, ARG233J, ARG244H, ARG244J, ARG263H, ARG263J, ARG274H, ARG274J, ASN135H, ASN135J, ASN200H, ASN200J, ASN85H, ASN85J, ASP105H, ASP105J, ASP167H, ASP167J, ASP224H, ASP224J, ASP237H, ASP237J, ASP250H, ASP250J, ASP253H, ASP253J, ASP260H, ASP260J, ASP277H, ASP277J, ASP62H, ASP62J, GLN124H, GLN124J, GLN142H, GLN142J, GLN160H, GLN160J, GLU100H, GLU100J, GLU102H, GLU102J, GLU108H, GLU108J, GLU159H, GLU159J, GLU163H, GLU163J, GLU168H, GLU168J, GLU180H, GLU180J, GLU198J, GLU205H, GLU205J, GLU239H, GLU239J, GLU265H, GLU265J, GLU268H, GLU268J, GLU270H, GLU270J, GLU64H, GLU64J, GLU96H, GLU96J, GLU97H, GLU97J, GLY113H, GLY113J, GLY140H, GLY140J, GLY141H, GLY141J, GLY147H, GLY147J, GLY164H, GLY164J, GLY182H, GLY182J, GLY223H, GLY223J, GLY248H, GLY248J, GLY249H, GLY249J, GLY257H, GLY257J, GLY275H, GLY275J, GLY63H, GLY63J, GLY93H, GLY93J, HIS258H, HIS258J, ILE174H, ILE174J, ILE178H, ILE178J, ILE232H, ILE232J, ILE66H, ILE66J, LEU103H, LEU103J, LEU106H, LEU106J, LEU117H, LEU117J, LEU121H, LEU121J, LEU122H, LEU122J, LEU143H, LEU143J, LEU158H, LEU158J, LEU161H, LEU161J, LEU165H, LEU165J, LEU177H, LEU177J, LEU234H, LEU234J, LEU236H, LEU236J, LEU243H, LEU243J, LEU245H, LEU245J, LEU247H, LEU247J, LEU255H, LEU255J, LEU259H, LEU259J, LEU266H, LEU266J, LEU83H, LEU83J, LYS155H, LYS155J, LYS206H, LYS206J, LYS227H, LYS227J, LYS240H, LYS240J, LYS271H, LYS271J, PHE107H, PHE107J, PHE112H, PHE112J, PHE139H, PHE139J, PHE145H, PHE145J, PHE148H, PHE148J, PHE172H, PHE172J, PHE17H, PHE17J, PHE184H, PHE184J, PHE254H, PHE254J, PHE95H, PHE95J, PRO114H, PRO114J, PRO123H, PRO123J, PRO171H, PRO171J, PRO181H, PRO181J, PRO201H, PRO201J, PRO222H, PRO222J, PRO225H, PRO225J, PRO242H, PRO242J, SER144H, SER144J, SER149H, SER149J, SER152H, SER152J, SER162H, SER162J, SER197H, SER197J, SER261H, SER261J, SER273H, SER273J, THR118H, THR118J, THR154H, THR154J, THR210H, THR210J, THR238H, THR238J, THR241H, THR241J, THR256H, THR256J, THR267H, THR267J, THR276H, THR276J, THR61H, THR61J, THR98H, THR98J, THR99H, THR99J, TRP269H, TRP269J, TYR151H, TYR151J, TYR203H, TYR203J, VAL111H, VAL111J, VAL133H, VAL133J, VAL169H, VAL169J, VAL179H, VAL179J, VAL207H, VAL207J, VAL252H, VAL252J, VAL262H, VAL262J, VAL272H, VAL272J, VAL60H, VAL60J, VAL92H, VAL92J
• I-J: ALA120I, ALA41J, ALA47J, ARG119I, ARG126I, ARG19J, ARG38J, ASP43J, ASP44J, GLN124I, GLU127I, GLU40J, LEU122I, LEU42J, LEU45J, PRO123I, THR39J