3LWW

structure of an open and closed conformation of human importin beta bound to the snurportin1 ibb-domain trapped in the same crystallographic asymmetric unit

• Total interactions analyzed: 6
• Total true interactions: 5
• Strongest Interaction:
  • Chains: C-D
  • Int. Res.: 130
  • Norm. En. per Res.: -2.9822
• Hub Node: A(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-57.8133	-203.6774	-360.954	-622.4448	209	46	1	19075	13	80	53
A-C	-24.8083	-88.5802	-185.397	-298.7855	157	16	2	10174	3	92	70
A-D	0.0	0.0	-0.001	-0.001	4	0	0	3	0	2	1
B-C	0.0	1.5633	-2.3348	-0.7715	8	0	0	129	0	10	4
C-D	-19.185	-148.6822	-219.817	-387.6842	130	21	2	11277	9	69	57

Interface residues

• A-B: ALA347A, ALA348A, ALA428A, ALA429A, ALA467A, ALA473A, ALA528A, ALA586A, ALA62B, ALA631A, ALA669A, ALA670A, ALA680A, ALA721A, ALA723A, ALA768A, ALA816A, ALA819A, ALA858A, ALA862A, ALA865A, ARG27B, ARG425A, ARG434A, ARG43B, ARG44B, ARG45B, ARG465A, ARG46B, ARG525A, ARG55B, ARG593A, ARG63B, ARG64B, ARG679A, ASN285A, ASN343A, ASN469A, ASN522A, ASN523A, ASN538A, ASN590A, ASN60B, ASP288A, ASP337A, ASP338A, ASP339A, ASP340A, ASP341A, ASP384A, ASP426A, ASP579A, ASP57B, ASP627A, ASP676A, ASP719A, ASP779A, ASP824A, CYS287A, CYS345A, CYS351A, CYS392A, CYS471A, CYS585A, CYS678A, CYS817A, CYS826A, GLN278A, GLN30B, GLN333A, GLN40B, GLN51B, GLN581A, GLN589A, GLN625A, GLN665A, GLN682A, GLN712A, GLN774A, GLU281A, GLU289A, GLU395A, GLU39B, GLU42B, GLU437A, GLU479A, GLU49B, GLU530A, GLU534A, GLU626A, GLU637A, GLU760A, GLU763A, GLU767A, GLU868A, GLY349A, GLY391A, GLY433A, GLY672A, GLY675A, GLY718A, GLY771A, GLY775A, GLY778A, GLY813A, GLY820A, GLY823A, HIS61B, ILE280A, ILE720A, ILE772A, ILE822A, LEU277A, LEU28B, LEU330A, LEU354A, LEU38B, LEU438A, LEU47B, LEU48B, LEU50B, LEU524A, LEU56B, LEU583A, LEU584A, LEU629A, LEU668A, LEU673A, LEU677A, LEU714A, LEU722A, LEU766A, LEU821A, LEU825A, LEU861A, LYS32B, LYS346A, LYS34B, LYS52B, LYS537A, LYS54B, LYS777A, LYS857A, LYS859A, LYS867A, MET291A, MET353A, MET388A, MET533A, MET630A, PHE282A, PHE717A, PRO26B, PRO464A, PRO711A, SER246A, SER284A, SER29B, SER33B, SER36B, SER37B, SER41B, SER468A, SER475A, SER476A, SER526A, SER527A, SER531A, SER53B, SER582A, SER633A, SER715A, SER764A, THR427A, THR431A, THR587A, THR634A, THR770A, THR827A, THR860A, THR863A, THR866A, TRP283A, TRP342A, TRP430A, TRP472A, TRP864A, TYR31B, TYR35B, TYR529A, TYR58B, TYR769A, VAL242A, VAL286A, VAL350A, VAL387A, VAL423A, VAL424A, VAL466A, VAL470A, VAL59B, VAL632A, VAL636A, VAL666A, VAL671A, VAL674A, VAL716A, VAL773A, VAL814A
• A-C: ALA193C, ALA197C, ALA236C, ALA347C, ALA53C, ALA56C, ALA662C, ALA723A, ALA839A, ARG105C, ARG15C, ARG232C, ARG54C, ARG574C, ARG707C, ARG793A, ARG840A, ARG851A, ARG870A, ASN188C, ASN189C, ASN196C, ASN200C, ASN336C, ASN343C, ASN578C, ASN63C, ASN660C, ASN782A, ASP14C, ASP230C, ASP271C, ASP273C, ASP334C, ASP337C, ASP338C, ASP339C, ASP340C, ASP341C, ASP579C, ASP753C, ASP779A, ASP786A, ASP802A, ASP832A, GLN111C, GLN159C, GLN22C, GLN239C, GLN278C, GLN51C, GLN625C, GLN665C, GLN682A, GLN740A, GLN780A, GLN791A, GLU144C, GLU148C, GLU152C, GLU17C, GLU19C, GLU274C, GLU335C, GLU663C, GLU727A, GLU733A, GLU781A, GLU795A, GLU838A, GLU845A, GLU868A, GLU8C, GLY155C, GLY622C, GLY726A, GLY778A, HIS145C, HIS520C, HIS706C, HIS784A, HIS844A, ILE272C, ILE575C, ILE724A, ILE772A, ILE797A, ILE843A, LEU16C, LEU18C, LEU192C, LEU199C, LEU277C, LEU59C, LEU681A, LEU732A, LEU736A, LEU776A, LEU789A, LEU798A, LEU7C, LEU834A, LEU836A, LEU869A, LEU872A, LYS62C, LYS68C, LYS729A, LYS730A, LYS831A, LYS835A, LYS859A, LYS867A, LYS871A, LYS873A, LYS9C, MET788A, MET842A, PHE728A, PHE796A, PHE829A, PRO106C, PRO13C, PRO344C, PRO785A, PRO792A, PRO841A, SER12C, SER570C, SER572C, SER683A, SER799A, THR103C, THR10C, THR231C, THR571C, THR848A, THR863A, THR866A, TRP342C, TRP864A, TYR104C, TYR156C, TYR664C, TYR731A, TYR752C, VAL11C, VAL235C, VAL275C, VAL52C, VAL55C, VAL666C, VAL734A, VAL783A, VAL790A, VAL794A, VAL837A
• A-D: ARG44D, ASP779A, GLN40D, GLN780A
• B-C: ALA62B, ARG64B, ASP338C, GLN521C, GLN576C, HIS520C, HIS61B, ILE575C
• C-D: ALA528C, ALA586C, ALA62D, ALA631C, ALA669C, ALA670C, ALA680C, ALA723C, ALA768C, ALA816C, ALA819C, ALA858C, ALA862C, ALA865C, ARG43D, ARG44D, ARG45D, ARG46D, ARG55D, ARG593C, ARG63D, ARG64D, ARG679C, ASN590C, ASN60D, ASN856C, ASP339C, ASP340C, ASP57D, ASP627C, ASP676C, ASP719C, ASP779C, ASP824C, CYS585C, CYS678C, CYS817C, GLN40D, GLN51D, GLN589C, GLN665C, GLN682C, GLN712C, GLN774C, GLU39D, GLU42D, GLU479C, GLU530C, GLU534C, GLU626C, GLU637C, GLU760C, GLU763C, GLU767C, GLU868C, GLY640C, GLY672C, GLY675C, GLY718C, GLY771C, GLY775C, GLY778C, GLY813C, GLY820C, GLY823C, HIS61D, ILE713C, ILE720C, ILE724C, ILE822C, LEU47D, LEU48D, LEU50D, LEU56D, LEU583C, LEU584C, LEU588C, LEU629C, LEU635C, LEU668C, LEU673C, LEU677C, LEU714C, LEU722C, LEU766C, LEU821C, LEU825C, LEU861C, LYS52D, LYS537C, LYS54D, LYS777C, LYS857C, LYS867C, LYS871C, MET533C, MET630C, PHE717C, PRO711C, SER41D, SER476C, SER526C, SER527C, SER53D, SER582C, SER633C, SER683C, SER708C, SER715C, SER764C, THR587C, THR634C, THR770C, THR827C, THR860C, THR863C, TRP472C, TRP864C, TYR529C, TYR58D, TYR664C, TYR769C, VAL59D, VAL632C, VAL636C, VAL638C, VAL671C, VAL674C, VAL716C, VAL773C