3LUE

model of alpha-actinin ch1 bound to f-actin

• Total interactions analyzed: 190
• Total true interactions: 35
• Strongest Interaction:
  • Chains: J-S
  • Int. Res.: 52
  • Norm. En. per Res.: -0.2036
• Hub Node: C(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	0.0	7.8096	-17.1385	-9.3289	50	5	0	1796	0	25	15
A-C	-225.5901	-8.1312	10602.5	10368.7787	131	1352	19	30120	2	40	37
A-K	-58.3504	-1.1345	2276.69	2217.2052	104	344	10	14822	2	30	36
B-C	0.0	7.8076	-17.1459	-9.3383	50	5	0	1795	0	25	15
B-D	-225.3684	-8.1315	10601.6	10368.1001	131	1351	19	30126	2	40	37
B-M	-57.7694	-1.0054	2271.24	2212.4652	104	344	10	14834	2	30	36
C-D	0.0	7.8099	-17.1559	-9.346	50	5	0	1795	0	25	15
C-E	-225.3931	-8.1226	10753.0	10519.4844	131	1352	19	30127	2	40	37
C-K	-48.679	14.4457	64.035	29.8017	52	46	3	3661	0	19	12
C-L	-57.2194	-0.8691	2263.48	2205.3915	104	344	10	14842	2	30	36
D-E	0.0	7.8075	-17.1253	-9.3178	50	5	0	1796	0	25	15
D-F	-225.4747	-8.1393	10747.6	10513.9861	131	1352	19	30124	2	40	37
D-M	-50.2654	14.4958	47.9086	12.139	52	45	3	3651	0	19	12
D-O	-56.5829	-0.7253	2264.97	2207.6618	104	344	10	14855	2	30	36
E-F	0.0	7.8089	-17.1293	-9.3204	50	5	0	1795	0	25	15
E-G	-225.4508	-8.1264	10746.5	10512.9228	131	1351	19	30125	2	40	37
E-L	-51.8947	14.5576	45.9984	8.6613	52	44	3	3637	0	19	12
E-N	-56.0199	-0.6026	2264.87	2208.2475	105	344	10	14871	2	30	36
F-G	0.0	7.8088	-17.1464	-9.3376	50	5	0	1795	0	25	15
F-H	-225.2182	-8.1336	10600.6	10367.2481	131	1351	19	30128	2	40	37
F-O	-53.3323	14.6097	43.2393	4.5167	52	44	3	3627	0	19	12
F-Q	-55.4439	-0.48	2282.79	2226.8661	105	343	10	14887	2	29	36
G-H	0.0	7.8086	-17.1244	-9.3158	50	5	0	1795	0	25	15
G-I	-225.3948	-8.1284	10747.4	10513.8768	131	1351	19	30125	2	40	37
G-N	-54.9574	14.6651	40.8696	0.5773	52	44	3	3611	0	19	12
G-P	-54.9285	-0.3276	2272.95	2217.6939	105	344	10	14899	2	29	36
H-I	0.0	7.8089	-17.1651	-9.3562	50	5	0	1795	0	25	15
H-J	-225.4803	-8.1311	10744.3	10510.6886	131	1351	19	30122	2	40	37
H-Q	-56.3024	14.726	38.5604	-3.016	52	44	3	3599	0	19	12
H-S	-54.3053	-0.2093	2276.35	2221.8355	105	344	10	14897	2	29	36
I-J	0.0	7.8092	-17.1752	-9.366	50	5	0	1796	0	25	15
I-P	-57.7606	14.78	36.2394	-6.7412	52	44	3	3595	0	19	12
I-R	-56.7935	-0.0674	2285.61	2228.7492	105	345	10	14922	2	29	36
J-S	-59.202	14.8353	33.7787	-10.588	52	44	3	3589	0	19	12
J-T	-56.1918	0.0535	2310.39	2254.2516	105	346	10	14943	2	29	36

Interface residues

• A-B: ALA114B, ALA174B, ARG177B, ARG196A, ARG206A, ARG256A, ARG290B, ARG372B, ASN111B, ASN252A, ASP179B, ASP286B, ASP288B, CYS285B, GLU195A, GLU205A, GLU253A, GLU270A, GLU270B, GLY197A, GLY268A, GLY268B, GLY63A, HIS173B, ILE175B, ILE192A, LEU110B, LEU176B, LEU193A, LEU267A, LYS113B, LYS191A, LYS284B, MET227A, MET269A, MET269B, MET283B, PHE200A, PHE266A, PRO112B, PRO172B, SER265A, SER271B, THR194A, THR201A, THR202A, THR203A, TYR188A, TYR198A, VAL287B
• A-C: ALA138C, ALA144C, ALA170C, ALA174C, ALA204A, ALA295C, ALA321C, ALA58A, ARG147C, ARG206A, ARG290C, ARG37A, ARG39A, ARG62A, ASN296C, ASP154C, ASP244A, ASP286C, ASP288C, ASP292C, ASP51A, ASP56A, CYS285C, GLN137C, GLN246A, GLN353C, GLN354C, GLN41A, GLN49A, GLN59A, GLU167C, GLU205A, GLU207A, GLU241A, GLU57A, GLY146C, GLY150C, GLY168C, GLY245A, GLY342C, GLY36A, GLY42A, GLY46A, GLY48A, GLY55A, GLY63A, HIS173C, HIS40A, ILE151C, ILE165C, ILE208A, ILE248A, ILE282C, ILE289C, ILE317C, ILE327C, ILE330C, ILE345C, ILE34A, ILE64A, LEU140C, LEU142C, LEU171C, LEU242A, LEU293C, LEU299C, LEU320C, LEU346C, LEU349C, LEU65A, LEU67A, LYS284C, LYS291C, LYS326C, LYS50A, LYS61A, MET153C, MET190A, MET283C, MET325C, MET355C, MET44A, MET47A, PHE200A, PHE279C, PHE352C, PHE375C, PRO164C, PRO172C, PRO243A, PRO322C, PRO332C, PRO38A, SER141C, SER145C, SER199A, SER300C, SER323C, SER338C, SER350C, SER52A, SER60A, THR148C, THR149C, THR201A, THR202A, THR203A, THR297C, THR318C, THR324C, THR351C, THR66A, TYR133C, TYR143C, TYR166C, TYR169C, TYR240A, TYR294C, TYR53A, VAL139C, VAL152C, VAL163C, VAL209A, VAL247A, VAL287C, VAL298C, VAL339C, VAL35A, VAL43A, VAL45A, VAL54A
• A-K: ALA105K, ALA115K, ALA126K, ALA29A, ALA58A, ALA97A, ARG100K, ARG147K, ARG28A, ARG37A, ARG48K, ARG95A, ASN108K, ASN133K, ASN92A, ASP112K, ASP131K, ASP51A, ASP56A, ASP80A, ASP81A, GLN41A, GLN46K, GLN47K, GLN49A, GLN59A, GLU100A, GLU127K, GLU128K, GLU44K, GLU57A, GLU83A, GLU93A, GLU99A, GLY118K, GLY125K, GLY139K, GLY36A, GLY46A, GLY48A, GLY55A, HIS101A, HIS102K, HIS87A, HIS88A, ILE104K, ILE114K, ILE124K, ILE129K, ILE141K, ILE144K, ILE145K, ILE150K, ILE34A, ILE69K, ILE85A, LEU111K, LEU121K, LEU138K, LEU146K, LEU65A, LEU67A, LEU94A, LYS103K, LYS120K, LYS135K, LYS50A, LYS61A, LYS68A, LYS84A, MET136K, MET140K, MET44A, MET47A, MET82A, PHE101K, PHE127A, PHE51K, PHE90A, PRO98A, SER116K, SER123K, SER52A, THR126A, THR137K, THR143K, THR50K, THR52K, THR89A, TRP142K, TRP43K, TRP54K, TRP86A, TYR53A, TYR69A, TYR91A, VAL107K, VAL119K, VAL122K, VAL130K, VAL35A, VAL43A, VAL54A, VAL96A
• B-C: ALA114C, ALA174C, ARG177C, ARG196B, ARG206B, ARG256B, ARG290C, ARG372C, ASN111C, ASN252B, ASP179C, ASP286C, ASP288C, CYS285C, GLU195B, GLU205B, GLU253B, GLU270B, GLU270C, GLY197B, GLY268B, GLY268C, GLY63B, HIS173C, ILE175C, ILE192B, LEU110C, LEU176C, LEU193B, LEU267B, LYS113C, LYS191B, LYS284C, MET227B, MET269B, MET269C, MET283C, PHE200B, PHE266B, PRO112C, PRO172C, SER265B, SER271C, THR194B, THR201B, THR202B, THR203B, TYR188B, TYR198B, VAL287C
• B-D: ALA138D, ALA144D, ALA170D, ALA174D, ALA204B, ALA295D, ALA321D, ALA58B, ARG147D, ARG206B, ARG290D, ARG37B, ARG39B, ARG62B, ASN296D, ASP154D, ASP244B, ASP286D, ASP288D, ASP292D, ASP51B, ASP56B, CYS285D, GLN137D, GLN246B, GLN353D, GLN354D, GLN41B, GLN49B, GLN59B, GLU167D, GLU205B, GLU207B, GLU241B, GLU57B, GLY146D, GLY150D, GLY168D, GLY245B, GLY342D, GLY36B, GLY42B, GLY46B, GLY48B, GLY55B, GLY63B, HIS173D, HIS40B, ILE151D, ILE165D, ILE208B, ILE248B, ILE282D, ILE289D, ILE317D, ILE327D, ILE330D, ILE345D, ILE34B, ILE64B, LEU140D, LEU142D, LEU171D, LEU242B, LEU293D, LEU299D, LEU320D, LEU346D, LEU349D, LEU65B, LEU67B, LYS284D, LYS291D, LYS326D, LYS50B, LYS61B, MET153D, MET190B, MET283D, MET325D, MET355D, MET44B, MET47B, PHE200B, PHE279D, PHE352D, PHE375D, PRO164D, PRO172D, PRO243B, PRO322D, PRO332D, PRO38B, SER141D, SER145D, SER199B, SER300D, SER323D, SER338D, SER350D, SER52B, SER60B, THR148D, THR149D, THR201B, THR202B, THR203B, THR297D, THR318D, THR324D, THR351D, THR66B, TYR133D, TYR143D, TYR166D, TYR169D, TYR240B, TYR294D, TYR53B, VAL139D, VAL152D, VAL163D, VAL209B, VAL247B, VAL287D, VAL298D, VAL339D, VAL35B, VAL43B, VAL45B, VAL54B
• B-M: ALA105M, ALA115M, ALA126M, ALA29B, ALA58B, ALA97B, ARG100M, ARG147M, ARG28B, ARG37B, ARG48M, ARG95B, ASN108M, ASN133M, ASN92B, ASP112M, ASP131M, ASP51B, ASP56B, ASP80B, ASP81B, GLN41B, GLN46M, GLN47M, GLN49B, GLN59B, GLU100B, GLU127M, GLU128M, GLU44M, GLU57B, GLU83B, GLU93B, GLU99B, GLY118M, GLY125M, GLY139M, GLY36B, GLY46B, GLY48B, GLY55B, HIS101B, HIS102M, HIS87B, HIS88B, ILE104M, ILE114M, ILE124M, ILE129M, ILE141M, ILE144M, ILE145M, ILE150M, ILE34B, ILE69M, ILE85B, LEU111M, LEU121M, LEU138M, LEU146M, LEU65B, LEU67B, LEU94B, LYS103M, LYS120M, LYS135M, LYS50B, LYS61B, LYS68B, LYS84B, MET136M, MET140M, MET44B, MET47B, MET82B, PHE101M, PHE127B, PHE51M, PHE90B, PRO98B, SER116M, SER123M, SER52B, THR126B, THR137M, THR143M, THR50M, THR52M, THR89B, TRP142M, TRP43M, TRP54M, TRP86B, TYR53B, TYR69B, TYR91B, VAL107M, VAL119M, VAL122M, VAL130M, VAL35B, VAL43B, VAL54B, VAL96B
• C-D: ALA114D, ALA174D, ARG177D, ARG196C, ARG206C, ARG256C, ARG290D, ARG372D, ASN111D, ASN252C, ASP179D, ASP286D, ASP288D, CYS285D, GLU195C, GLU205C, GLU253C, GLU270C, GLU270D, GLY197C, GLY268C, GLY268D, GLY63C, HIS173D, ILE175D, ILE192C, LEU110D, LEU176D, LEU193C, LEU267C, LYS113D, LYS191C, LYS284D, MET227C, MET269C, MET269D, MET283D, PHE200C, PHE266C, PRO112D, PRO172D, SER265C, SER271D, THR194C, THR201C, THR202C, THR203C, TYR188C, TYR198C, VAL287D
• C-E: ALA138E, ALA144E, ALA170E, ALA174E, ALA204C, ALA295E, ALA321E, ALA58C, ARG147E, ARG206C, ARG290E, ARG37C, ARG39C, ARG62C, ASN296E, ASP154E, ASP244C, ASP286E, ASP288E, ASP292E, ASP51C, ASP56C, CYS285E, GLN137E, GLN246C, GLN353E, GLN354E, GLN41C, GLN49C, GLN59C, GLU167E, GLU205C, GLU207C, GLU241C, GLU57C, GLY146E, GLY150E, GLY168E, GLY245C, GLY342E, GLY36C, GLY42C, GLY46C, GLY48C, GLY55C, GLY63C, HIS173E, HIS40C, ILE151E, ILE165E, ILE208C, ILE248C, ILE282E, ILE289E, ILE317E, ILE327E, ILE330E, ILE345E, ILE34C, ILE64C, LEU140E, LEU142E, LEU171E, LEU242C, LEU293E, LEU299E, LEU320E, LEU346E, LEU349E, LEU65C, LEU67C, LYS284E, LYS291E, LYS326E, LYS50C, LYS61C, MET153E, MET190C, MET283E, MET325E, MET355E, MET44C, MET47C, PHE200C, PHE279E, PHE352E, PHE375E, PRO164E, PRO172E, PRO243C, PRO322E, PRO332E, PRO38C, SER141E, SER145E, SER199C, SER300E, SER323E, SER338E, SER350E, SER52C, SER60C, THR148E, THR149E, THR201C, THR202C, THR203C, THR297E, THR318E, THR324E, THR351E, THR66C, TYR133E, TYR143E, TYR166E, TYR169E, TYR240C, TYR294E, TYR53C, VAL139E, VAL152E, VAL163E, VAL209C, VAL247C, VAL287E, VAL298E, VAL339E, VAL35C, VAL43C, VAL45C, VAL54C
• C-K: ALA105K, ALA126K, ALA144C, ALA22C, ALA26C, ARG100K, ARG147C, ARG93K, ASN106K, ASN108K, ASP112K, ASP131K, ASP24C, ASP25C, ASP2C, ASP95K, GLU127K, GLU128K, GLU167C, GLY125K, GLY146C, GLY168C, GLY23C, GLY342C, GLY97K, HIS102K, ILE104K, ILE341C, ILE345C, LEU142C, LEU346C, LEU349C, LYS103K, LYS109K, LYS96K, LYS98K, MET99K, PHE101K, PRO92K, SER123K, SER145C, SER344C, SER348C, SER350C, THR148C, THR149C, THR351C, TRP340C, TYR143C, TYR166C, TYR169C, VAL130K
• C-L: ALA105L, ALA115L, ALA126L, ALA29C, ALA58C, ALA97C, ARG100L, ARG147L, ARG28C, ARG37C, ARG48L, ARG95C, ASN108L, ASN133L, ASN92C, ASP112L, ASP131L, ASP51C, ASP56C, ASP80C, ASP81C, GLN41C, GLN46L, GLN47L, GLN49C, GLN59C, GLU100C, GLU127L, GLU128L, GLU44L, GLU57C, GLU83C, GLU93C, GLU99C, GLY118L, GLY125L, GLY139L, GLY36C, GLY46C, GLY48C, GLY55C, HIS101C, HIS102L, HIS87C, HIS88C, ILE104L, ILE114L, ILE124L, ILE129L, ILE141L, ILE144L, ILE145L, ILE150L, ILE34C, ILE69L, ILE85C, LEU111L, LEU121L, LEU138L, LEU146L, LEU65C, LEU67C, LEU94C, LYS103L, LYS120L, LYS135L, LYS50C, LYS61C, LYS68C, LYS84C, MET136L, MET140L, MET44C, MET47C, MET82C, PHE101L, PHE127C, PHE51L, PHE90C, PRO98C, SER116L, SER123L, SER52C, THR126C, THR137L, THR143L, THR50L, THR52L, THR89C, TRP142L, TRP43L, TRP54L, TRP86C, TYR53C, TYR69C, TYR91C, VAL107L, VAL119L, VAL122L, VAL130L, VAL35C, VAL43C, VAL54C, VAL96C
• D-E: ALA114E, ALA174E, ARG177E, ARG196D, ARG206D, ARG256D, ARG290E, ARG372E, ASN111E, ASN252D, ASP179E, ASP286E, ASP288E, CYS285E, GLU195D, GLU205D, GLU253D, GLU270D, GLU270E, GLY197D, GLY268D, GLY268E, GLY63D, HIS173E, ILE175E, ILE192D, LEU110E, LEU176E, LEU193D, LEU267D, LYS113E, LYS191D, LYS284E, MET227D, MET269D, MET269E, MET283E, PHE200D, PHE266D, PRO112E, PRO172E, SER265D, SER271E, THR194D, THR201D, THR202D, THR203D, TYR188D, TYR198D, VAL287E
• D-F: ALA138F, ALA144F, ALA170F, ALA174F, ALA204D, ALA295F, ALA321F, ALA58D, ARG147F, ARG206D, ARG290F, ARG37D, ARG39D, ARG62D, ASN296F, ASP154F, ASP244D, ASP286F, ASP288F, ASP292F, ASP51D, ASP56D, CYS285F, GLN137F, GLN246D, GLN353F, GLN354F, GLN41D, GLN49D, GLN59D, GLU167F, GLU205D, GLU207D, GLU241D, GLU57D, GLY146F, GLY150F, GLY168F, GLY245D, GLY342F, GLY36D, GLY42D, GLY46D, GLY48D, GLY55D, GLY63D, HIS173F, HIS40D, ILE151F, ILE165F, ILE208D, ILE248D, ILE282F, ILE289F, ILE317F, ILE327F, ILE330F, ILE345F, ILE34D, ILE64D, LEU140F, LEU142F, LEU171F, LEU242D, LEU293F, LEU299F, LEU320F, LEU346F, LEU349F, LEU65D, LEU67D, LYS284F, LYS291F, LYS326F, LYS50D, LYS61D, MET153F, MET190D, MET283F, MET325F, MET355F, MET44D, MET47D, PHE200D, PHE279F, PHE352F, PHE375F, PRO164F, PRO172F, PRO243D, PRO322F, PRO332F, PRO38D, SER141F, SER145F, SER199D, SER300F, SER323F, SER338F, SER350F, SER52D, SER60D, THR148F, THR149F, THR201D, THR202D, THR203D, THR297F, THR318F, THR324F, THR351F, THR66D, TYR133F, TYR143F, TYR166F, TYR169F, TYR240D, TYR294F, TYR53D, VAL139F, VAL152F, VAL163F, VAL209D, VAL247D, VAL287F, VAL298F, VAL339F, VAL35D, VAL43D, VAL45D, VAL54D
• D-M: ALA105M, ALA126M, ALA144D, ALA22D, ALA26D, ARG100M, ARG147D, ARG93M, ASN106M, ASN108M, ASP112M, ASP131M, ASP24D, ASP25D, ASP2D, ASP95M, GLU127M, GLU128M, GLU167D, GLY125M, GLY146D, GLY168D, GLY23D, GLY342D, GLY97M, HIS102M, ILE104M, ILE341D, ILE345D, LEU142D, LEU346D, LEU349D, LYS103M, LYS109M, LYS96M, LYS98M, MET99M, PHE101M, PRO92M, SER123M, SER145D, SER344D, SER348D, SER350D, THR148D, THR149D, THR351D, TRP340D, TYR143D, TYR166D, TYR169D, VAL130M
• D-O: ALA105O, ALA115O, ALA126O, ALA29D, ALA58D, ALA97D, ARG100O, ARG147O, ARG28D, ARG37D, ARG48O, ARG95D, ASN108O, ASN133O, ASN92D, ASP112O, ASP131O, ASP51D, ASP56D, ASP80D, ASP81D, GLN41D, GLN46O, GLN47O, GLN49D, GLN59D, GLU100D, GLU127O, GLU128O, GLU44O, GLU57D, GLU83D, GLU93D, GLU99D, GLY118O, GLY125O, GLY139O, GLY36D, GLY46D, GLY48D, GLY55D, HIS101D, HIS102O, HIS87D, HIS88D, ILE104O, ILE114O, ILE124O, ILE129O, ILE141O, ILE144O, ILE145O, ILE150O, ILE34D, ILE69O, ILE85D, LEU111O, LEU121O, LEU138O, LEU146O, LEU65D, LEU67D, LEU94D, LYS103O, LYS120O, LYS135O, LYS50D, LYS61D, LYS68D, LYS84D, MET136O, MET140O, MET44D, MET47D, MET82D, PHE101O, PHE127D, PHE51O, PHE90D, PRO98D, SER116O, SER123O, SER52D, THR126D, THR137O, THR143O, THR50O, THR52O, THR89D, TRP142O, TRP43O, TRP54O, TRP86D, TYR53D, TYR69D, TYR91D, VAL107O, VAL119O, VAL122O, VAL130O, VAL35D, VAL43D, VAL54D, VAL96D
• E-F: ALA114F, ALA174F, ARG177F, ARG196E, ARG206E, ARG256E, ARG290F, ARG372F, ASN111F, ASN252E, ASP179F, ASP286F, ASP288F, CYS285F, GLU195E, GLU205E, GLU253E, GLU270E, GLU270F, GLY197E, GLY268E, GLY268F, GLY63E, HIS173F, ILE175F, ILE192E, LEU110F, LEU176F, LEU193E, LEU267E, LYS113F, LYS191E, LYS284F, MET227E, MET269E, MET269F, MET283F, PHE200E, PHE266E, PRO112F, PRO172F, SER265E, SER271F, THR194E, THR201E, THR202E, THR203E, TYR188E, TYR198E, VAL287F
• E-G: ALA138G, ALA144G, ALA170G, ALA174G, ALA204E, ALA295G, ALA321G, ALA58E, ARG147G, ARG206E, ARG290G, ARG37E, ARG39E, ARG62E, ASN296G, ASP154G, ASP244E, ASP286G, ASP288G, ASP292G, ASP51E, ASP56E, CYS285G, GLN137G, GLN246E, GLN353G, GLN354G, GLN41E, GLN49E, GLN59E, GLU167G, GLU205E, GLU207E, GLU241E, GLU57E, GLY146G, GLY150G, GLY168G, GLY245E, GLY342G, GLY36E, GLY42E, GLY46E, GLY48E, GLY55E, GLY63E, HIS173G, HIS40E, ILE151G, ILE165G, ILE208E, ILE248E, ILE282G, ILE289G, ILE317G, ILE327G, ILE330G, ILE345G, ILE34E, ILE64E, LEU140G, LEU142G, LEU171G, LEU242E, LEU293G, LEU299G, LEU320G, LEU346G, LEU349G, LEU65E, LEU67E, LYS284G, LYS291G, LYS326G, LYS50E, LYS61E, MET153G, MET190E, MET283G, MET325G, MET355G, MET44E, MET47E, PHE200E, PHE279G, PHE352G, PHE375G, PRO164G, PRO172G, PRO243E, PRO322G, PRO332G, PRO38E, SER141G, SER145G, SER199E, SER300G, SER323G, SER338G, SER350G, SER52E, SER60E, THR148G, THR149G, THR201E, THR202E, THR203E, THR297G, THR318G, THR324G, THR351G, THR66E, TYR133G, TYR143G, TYR166G, TYR169G, TYR240E, TYR294G, TYR53E, VAL139G, VAL152G, VAL163G, VAL209E, VAL247E, VAL287G, VAL298G, VAL339G, VAL35E, VAL43E, VAL45E, VAL54E
• E-L: ALA105L, ALA126L, ALA144E, ALA22E, ALA26E, ARG100L, ARG147E, ARG93L, ASN106L, ASN108L, ASP112L, ASP131L, ASP24E, ASP25E, ASP2E, ASP95L, GLU127L, GLU128L, GLU167E, GLY125L, GLY146E, GLY168E, GLY23E, GLY342E, GLY97L, HIS102L, ILE104L, ILE341E, ILE345E, LEU142E, LEU346E, LEU349E, LYS103L, LYS109L, LYS96L, LYS98L, MET99L, PHE101L, PRO92L, SER123L, SER145E, SER344E, SER348E, SER350E, THR148E, THR149E, THR351E, TRP340E, TYR143E, TYR166E, TYR169E, VAL130L
• E-N: ALA105N, ALA115N, ALA126N, ALA29E, ALA58E, ALA97E, ARG100N, ARG147N, ARG28E, ARG37E, ARG48N, ARG95E, ASN108N, ASN133N, ASN92E, ASP112N, ASP131N, ASP51E, ASP56E, ASP80E, ASP81E, GLN41E, GLN46N, GLN47N, GLN49E, GLN59E, GLU100E, GLU127N, GLU128N, GLU44N, GLU57E, GLU83E, GLU93E, GLU99E, GLY118N, GLY125N, GLY139N, GLY36E, GLY46E, GLY48E, GLY55E, HIS101E, HIS102N, HIS87E, HIS88E, ILE104N, ILE114N, ILE124N, ILE129N, ILE141N, ILE144N, ILE145N, ILE150N, ILE34E, ILE69N, ILE85E, LEU111N, LEU121N, LEU138N, LEU146N, LEU65E, LEU67E, LEU94E, LYS103N, LYS120N, LYS135N, LYS50E, LYS61E, LYS68E, LYS84E, MET136N, MET140N, MET44E, MET47E, MET82E, PHE101N, PHE127E, PHE31E, PHE51N, PHE90E, PRO98E, SER116N, SER123N, SER52E, THR126E, THR137N, THR143N, THR50N, THR52N, THR89E, TRP142N, TRP43N, TRP54N, TRP86E, TYR53E, TYR69E, TYR91E, VAL107N, VAL119N, VAL122N, VAL130N, VAL35E, VAL43E, VAL54E, VAL96E
• F-G: ALA114G, ALA174G, ARG177G, ARG196F, ARG206F, ARG256F, ARG290G, ARG372G, ASN111G, ASN252F, ASP179G, ASP286G, ASP288G, CYS285G, GLU195F, GLU205F, GLU253F, GLU270F, GLU270G, GLY197F, GLY268F, GLY268G, GLY63F, HIS173G, ILE175G, ILE192F, LEU110G, LEU176G, LEU193F, LEU267F, LYS113G, LYS191F, LYS284G, MET227F, MET269F, MET269G, MET283G, PHE200F, PHE266F, PRO112G, PRO172G, SER265F, SER271G, THR194F, THR201F, THR202F, THR203F, TYR188F, TYR198F, VAL287G
• F-H: ALA138H, ALA144H, ALA170H, ALA174H, ALA204F, ALA295H, ALA321H, ALA58F, ARG147H, ARG206F, ARG290H, ARG37F, ARG39F, ARG62F, ASN296H, ASP154H, ASP244F, ASP286H, ASP288H, ASP292H, ASP51F, ASP56F, CYS285H, GLN137H, GLN246F, GLN353H, GLN354H, GLN41F, GLN49F, GLN59F, GLU167H, GLU205F, GLU207F, GLU241F, GLU57F, GLY146H, GLY150H, GLY168H, GLY245F, GLY342H, GLY36F, GLY42F, GLY46F, GLY48F, GLY55F, GLY63F, HIS173H, HIS40F, ILE151H, ILE165H, ILE208F, ILE248F, ILE282H, ILE289H, ILE317H, ILE327H, ILE330H, ILE345H, ILE34F, ILE64F, LEU140H, LEU142H, LEU171H, LEU242F, LEU293H, LEU299H, LEU320H, LEU346H, LEU349H, LEU65F, LEU67F, LYS284H, LYS291H, LYS326H, LYS50F, LYS61F, MET153H, MET190F, MET283H, MET325H, MET355H, MET44F, MET47F, PHE200F, PHE279H, PHE352H, PHE375H, PRO164H, PRO172H, PRO243F, PRO322H, PRO332H, PRO38F, SER141H, SER145H, SER199F, SER300H, SER323H, SER338H, SER350H, SER52F, SER60F, THR148H, THR149H, THR201F, THR202F, THR203F, THR297H, THR318H, THR324H, THR351H, THR66F, TYR133H, TYR143H, TYR166H, TYR169H, TYR240F, TYR294H, TYR53F, VAL139H, VAL152H, VAL163H, VAL209F, VAL247F, VAL287H, VAL298H, VAL339H, VAL35F, VAL43F, VAL45F, VAL54F
• F-O: ALA105O, ALA126O, ALA144F, ALA22F, ALA26F, ARG100O, ARG147F, ARG93O, ASN106O, ASN108O, ASP112O, ASP131O, ASP24F, ASP25F, ASP2F, ASP95O, GLU127O, GLU128O, GLU167F, GLY125O, GLY146F, GLY168F, GLY23F, GLY342F, GLY97O, HIS102O, ILE104O, ILE341F, ILE345F, LEU142F, LEU346F, LEU349F, LYS103O, LYS109O, LYS96O, LYS98O, MET99O, PHE101O, PRO92O, SER123O, SER145F, SER344F, SER348F, SER350F, THR148F, THR149F, THR351F, TRP340F, TYR143F, TYR166F, TYR169F, VAL130O
• F-Q: ALA105Q, ALA115Q, ALA126Q, ALA29F, ALA58F, ALA97F, ARG100Q, ARG147Q, ARG28F, ARG37F, ARG48Q, ARG95F, ASN108Q, ASN133Q, ASN92F, ASP112Q, ASP131Q, ASP51F, ASP56F, ASP80F, ASP81F, GLN41F, GLN46Q, GLN47Q, GLN49F, GLN59F, GLU100F, GLU127Q, GLU128Q, GLU44Q, GLU57F, GLU83F, GLU93F, GLU99F, GLY118Q, GLY125Q, GLY139Q, GLY36F, GLY46F, GLY48F, GLY55F, HIS101F, HIS102Q, HIS87F, HIS88F, ILE104Q, ILE114Q, ILE124Q, ILE129Q, ILE141Q, ILE144Q, ILE145Q, ILE150Q, ILE34F, ILE69Q, ILE85F, LEU111Q, LEU121Q, LEU138Q, LEU146Q, LEU65F, LEU67F, LEU94F, LYS103Q, LYS120Q, LYS135Q, LYS50F, LYS61F, LYS68F, LYS84F, MET136Q, MET140Q, MET44F, MET47F, MET82F, PHE101Q, PHE127F, PHE31F, PHE51Q, PHE90F, PRO98F, SER116Q, SER123Q, SER52F, THR126F, THR137Q, THR143Q, THR50Q, THR52Q, THR89F, TRP142Q, TRP43Q, TRP54Q, TRP86F, TYR53F, TYR69F, TYR91F, VAL107Q, VAL119Q, VAL122Q, VAL130Q, VAL35F, VAL43F, VAL54F, VAL96F
• G-H: ALA114H, ALA174H, ARG177H, ARG196G, ARG206G, ARG256G, ARG290H, ARG372H, ASN111H, ASN252G, ASP179H, ASP286H, ASP288H, CYS285H, GLU195G, GLU205G, GLU253G, GLU270G, GLU270H, GLY197G, GLY268G, GLY268H, GLY63G, HIS173H, ILE175H, ILE192G, LEU110H, LEU176H, LEU193G, LEU267G, LYS113H, LYS191G, LYS284H, MET227G, MET269G, MET269H, MET283H, PHE200G, PHE266G, PRO112H, PRO172H, SER265G, SER271H, THR194G, THR201G, THR202G, THR203G, TYR188G, TYR198G, VAL287H
• G-I: ALA138I, ALA144I, ALA170I, ALA174I, ALA204G, ALA295I, ALA321I, ALA58G, ARG147I, ARG206G, ARG290I, ARG37G, ARG39G, ARG62G, ASN296I, ASP154I, ASP244G, ASP286I, ASP288I, ASP292I, ASP51G, ASP56G, CYS285I, GLN137I, GLN246G, GLN353I, GLN354I, GLN41G, GLN49G, GLN59G, GLU167I, GLU205G, GLU207G, GLU241G, GLU57G, GLY146I, GLY150I, GLY168I, GLY245G, GLY342I, GLY36G, GLY42G, GLY46G, GLY48G, GLY55G, GLY63G, HIS173I, HIS40G, ILE151I, ILE165I, ILE208G, ILE248G, ILE282I, ILE289I, ILE317I, ILE327I, ILE330I, ILE345I, ILE34G, ILE64G, LEU140I, LEU142I, LEU171I, LEU242G, LEU293I, LEU299I, LEU320I, LEU346I, LEU349I, LEU65G, LEU67G, LYS284I, LYS291I, LYS326I, LYS50G, LYS61G, MET153I, MET190G, MET283I, MET325I, MET355I, MET44G, MET47G, PHE200G, PHE279I, PHE352I, PHE375I, PRO164I, PRO172I, PRO243G, PRO322I, PRO332I, PRO38G, SER141I, SER145I, SER199G, SER300I, SER323I, SER338I, SER350I, SER52G, SER60G, THR148I, THR149I, THR201G, THR202G, THR203G, THR297I, THR318I, THR324I, THR351I, THR66G, TYR133I, TYR143I, TYR166I, TYR169I, TYR240G, TYR294I, TYR53G, VAL139I, VAL152I, VAL163I, VAL209G, VAL247G, VAL287I, VAL298I, VAL339I, VAL35G, VAL43G, VAL45G, VAL54G
• G-N: ALA105N, ALA126N, ALA144G, ALA22G, ALA26G, ARG100N, ARG147G, ARG93N, ASN106N, ASN108N, ASP112N, ASP131N, ASP24G, ASP25G, ASP2G, ASP95N, GLU127N, GLU128N, GLU167G, GLY125N, GLY146G, GLY168G, GLY23G, GLY342G, GLY97N, HIS102N, ILE104N, ILE341G, ILE345G, LEU142G, LEU346G, LEU349G, LYS103N, LYS109N, LYS96N, LYS98N, MET99N, PHE101N, PRO92N, SER123N, SER145G, SER344G, SER348G, SER350G, THR148G, THR149G, THR351G, TRP340G, TYR143G, TYR166G, TYR169G, VAL130N
• G-P: ALA105P, ALA115P, ALA126P, ALA29G, ALA58G, ALA97G, ARG100P, ARG147P, ARG28G, ARG37G, ARG48P, ARG95G, ASN108P, ASN133P, ASN92G, ASP112P, ASP131P, ASP51G, ASP56G, ASP80G, ASP81G, GLN41G, GLN46P, GLN47P, GLN49G, GLN59G, GLU100G, GLU127P, GLU128P, GLU44P, GLU57G, GLU83G, GLU93G, GLU99G, GLY118P, GLY125P, GLY139P, GLY36G, GLY46G, GLY48G, GLY55G, HIS101G, HIS102P, HIS87G, HIS88G, ILE104P, ILE114P, ILE124P, ILE129P, ILE141P, ILE144P, ILE145P, ILE150P, ILE34G, ILE69P, ILE85G, LEU111P, LEU121P, LEU138P, LEU146P, LEU65G, LEU67G, LEU94G, LYS103P, LYS120P, LYS135P, LYS50G, LYS61G, LYS68G, LYS84G, MET136P, MET140P, MET44G, MET47G, MET82G, PHE101P, PHE127G, PHE31G, PHE51P, PHE90G, PRO98G, SER116P, SER123P, SER52G, THR126G, THR137P, THR143P, THR50P, THR52P, THR89G, TRP142P, TRP43P, TRP54P, TRP86G, TYR53G, TYR69G, TYR91G, VAL107P, VAL119P, VAL122P, VAL130P, VAL35G, VAL43G, VAL54G, VAL96G
• H-I: ALA114I, ALA174I, ARG177I, ARG196H, ARG206H, ARG256H, ARG290I, ARG372I, ASN111I, ASN252H, ASP179I, ASP286I, ASP288I, CYS285I, GLU195H, GLU205H, GLU253H, GLU270H, GLU270I, GLY197H, GLY268H, GLY268I, GLY63H, HIS173I, ILE175I, ILE192H, LEU110I, LEU176I, LEU193H, LEU267H, LYS113I, LYS191H, LYS284I, MET227H, MET269H, MET269I, MET283I, PHE200H, PHE266H, PRO112I, PRO172I, SER265H, SER271I, THR194H, THR201H, THR202H, THR203H, TYR188H, TYR198H, VAL287I
• H-J: ALA138J, ALA144J, ALA170J, ALA174J, ALA204H, ALA295J, ALA321J, ALA58H, ARG147J, ARG206H, ARG290J, ARG37H, ARG39H, ARG62H, ASN296J, ASP154J, ASP244H, ASP286J, ASP288J, ASP292J, ASP51H, ASP56H, CYS285J, GLN137J, GLN246H, GLN353J, GLN354J, GLN41H, GLN49H, GLN59H, GLU167J, GLU205H, GLU207H, GLU241H, GLU57H, GLY146J, GLY150J, GLY168J, GLY245H, GLY342J, GLY36H, GLY42H, GLY46H, GLY48H, GLY55H, GLY63H, HIS173J, HIS40H, ILE151J, ILE165J, ILE208H, ILE248H, ILE282J, ILE289J, ILE317J, ILE327J, ILE330J, ILE345J, ILE34H, ILE64H, LEU140J, LEU142J, LEU171J, LEU242H, LEU293J, LEU299J, LEU320J, LEU346J, LEU349J, LEU65H, LEU67H, LYS284J, LYS291J, LYS326J, LYS50H, LYS61H, MET153J, MET190H, MET283J, MET325J, MET355J, MET44H, MET47H, PHE200H, PHE279J, PHE352J, PHE375J, PRO164J, PRO172J, PRO243H, PRO322J, PRO332J, PRO38H, SER141J, SER145J, SER199H, SER300J, SER323J, SER338J, SER350J, SER52H, SER60H, THR148J, THR149J, THR201H, THR202H, THR203H, THR297J, THR318J, THR324J, THR351J, THR66H, TYR133J, TYR143J, TYR166J, TYR169J, TYR240H, TYR294J, TYR53H, VAL139J, VAL152J, VAL163J, VAL209H, VAL247H, VAL287J, VAL298J, VAL339J, VAL35H, VAL43H, VAL45H, VAL54H
• H-Q: ALA105Q, ALA126Q, ALA144H, ALA22H, ALA26H, ARG100Q, ARG147H, ARG93Q, ASN106Q, ASN108Q, ASP112Q, ASP131Q, ASP24H, ASP25H, ASP2H, ASP95Q, GLU127Q, GLU128Q, GLU167H, GLY125Q, GLY146H, GLY168H, GLY23H, GLY342H, GLY97Q, HIS102Q, ILE104Q, ILE341H, ILE345H, LEU142H, LEU346H, LEU349H, LYS103Q, LYS109Q, LYS96Q, LYS98Q, MET99Q, PHE101Q, PRO92Q, SER123Q, SER145H, SER344H, SER348H, SER350H, THR148H, THR149H, THR351H, TRP340H, TYR143H, TYR166H, TYR169H, VAL130Q
• H-S: ALA105S, ALA115S, ALA126S, ALA29H, ALA58H, ALA97H, ARG100S, ARG147S, ARG28H, ARG37H, ARG48S, ARG95H, ASN108S, ASN133S, ASN92H, ASP112S, ASP131S, ASP51H, ASP56H, ASP80H, ASP81H, GLN41H, GLN46S, GLN47S, GLN49H, GLN59H, GLU100H, GLU127S, GLU128S, GLU44S, GLU57H, GLU83H, GLU93H, GLU99H, GLY118S, GLY125S, GLY139S, GLY36H, GLY46H, GLY48H, GLY55H, HIS101H, HIS102S, HIS87H, HIS88H, ILE104S, ILE114S, ILE124S, ILE129S, ILE141S, ILE144S, ILE145S, ILE150S, ILE34H, ILE69S, ILE85H, LEU111S, LEU121S, LEU138S, LEU146S, LEU65H, LEU67H, LEU94H, LYS103S, LYS120S, LYS135S, LYS50H, LYS61H, LYS68H, LYS84H, MET136S, MET140S, MET44H, MET47H, MET82H, PHE101S, PHE127H, PHE31H, PHE51S, PHE90H, PRO98H, SER116S, SER123S, SER52H, THR126H, THR137S, THR143S, THR50S, THR52S, THR89H, TRP142S, TRP43S, TRP54S, TRP86H, TYR53H, TYR69H, TYR91H, VAL107S, VAL119S, VAL122S, VAL130S, VAL35H, VAL43H, VAL54H, VAL96H
• I-J: ALA114J, ALA174J, ARG177J, ARG196I, ARG206I, ARG256I, ARG290J, ARG372J, ASN111J, ASN252I, ASP179J, ASP286J, ASP288J, CYS285J, GLU195I, GLU205I, GLU253I, GLU270I, GLU270J, GLY197I, GLY268I, GLY268J, GLY63I, HIS173J, ILE175J, ILE192I, LEU110J, LEU176J, LEU193I, LEU267I, LYS113J, LYS191I, LYS284J, MET227I, MET269I, MET269J, MET283J, PHE200I, PHE266I, PRO112J, PRO172J, SER265I, SER271J, THR194I, THR201I, THR202I, THR203I, TYR188I, TYR198I, VAL287J
• I-P: ALA105P, ALA126P, ALA144I, ALA22I, ALA26I, ARG100P, ARG147I, ARG93P, ASN106P, ASN108P, ASP112P, ASP131P, ASP24I, ASP25I, ASP2I, ASP95P, GLU127P, GLU128P, GLU167I, GLY125P, GLY146I, GLY168I, GLY23I, GLY342I, GLY97P, HIS102P, ILE104P, ILE341I, ILE345I, LEU142I, LEU346I, LEU349I, LYS103P, LYS109P, LYS96P, LYS98P, MET99P, PHE101P, PRO92P, SER123P, SER145I, SER344I, SER348I, SER350I, THR148I, THR149I, THR351I, TRP340I, TYR143I, TYR166I, TYR169I, VAL130P
• I-R: ALA105R, ALA115R, ALA126R, ALA29I, ALA58I, ALA97I, ARG100R, ARG147R, ARG28I, ARG37I, ARG48R, ARG95I, ASN108R, ASN133R, ASN92I, ASP112R, ASP131R, ASP51I, ASP56I, ASP80I, ASP81I, GLN41I, GLN46R, GLN47R, GLN49I, GLN59I, GLU100I, GLU127R, GLU128R, GLU44R, GLU57I, GLU83I, GLU93I, GLU99I, GLY118R, GLY125R, GLY139R, GLY36I, GLY46I, GLY48I, GLY55I, HIS101I, HIS102R, HIS87I, HIS88I, ILE104R, ILE114R, ILE124R, ILE129R, ILE141R, ILE144R, ILE145R, ILE150R, ILE34I, ILE69R, ILE85I, LEU111R, LEU121R, LEU138R, LEU146R, LEU65I, LEU67I, LEU94I, LYS103R, LYS120R, LYS135R, LYS50I, LYS61I, LYS68I, LYS84I, MET136R, MET140R, MET44I, MET47I, MET82I, PHE101R, PHE127I, PHE31I, PHE51R, PHE90I, PRO98I, SER116R, SER123R, SER52I, THR126I, THR137R, THR143R, THR50R, THR52R, THR89I, TRP142R, TRP43R, TRP54R, TRP86I, TYR53I, TYR69I, TYR91I, VAL107R, VAL119R, VAL122R, VAL130R, VAL35I, VAL43I, VAL54I, VAL96I
• J-S: ALA105S, ALA126S, ALA144J, ALA22J, ALA26J, ARG100S, ARG147J, ARG93S, ASN106S, ASN108S, ASP112S, ASP131S, ASP24J, ASP25J, ASP2J, ASP95S, GLU127S, GLU128S, GLU167J, GLY125S, GLY146J, GLY168J, GLY23J, GLY342J, GLY97S, HIS102S, ILE104S, ILE341J, ILE345J, LEU142J, LEU346J, LEU349J, LYS103S, LYS109S, LYS96S, LYS98S, MET99S, PHE101S, PRO92S, SER123S, SER145J, SER344J, SER348J, SER350J, THR148J, THR149J, THR351J, TRP340J, TYR143J, TYR166J, TYR169J, VAL130S
• J-T: ALA105T, ALA115T, ALA126T, ALA29J, ALA58J, ALA97J, ARG100T, ARG147T, ARG28J, ARG37J, ARG48T, ARG95J, ASN108T, ASN133T, ASN92J, ASP112T, ASP131T, ASP51J, ASP56J, ASP80J, ASP81J, GLN41J, GLN46T, GLN47T, GLN49J, GLN59J, GLU100J, GLU127T, GLU128T, GLU44T, GLU57J, GLU83J, GLU93J, GLU99J, GLY118T, GLY125T, GLY139T, GLY36J, GLY46J, GLY48J, GLY55J, HIS101J, HIS102T, HIS87J, HIS88J, ILE104T, ILE114T, ILE124T, ILE129T, ILE141T, ILE144T, ILE145T, ILE150T, ILE34J, ILE69T, ILE85J, LEU111T, LEU121T, LEU138T, LEU146T, LEU65J, LEU67J, LEU94J, LYS103T, LYS120T, LYS135T, LYS50J, LYS61J, LYS68J, LYS84J, MET136T, MET140T, MET44J, MET47J, MET82J, PHE101T, PHE127J, PHE31J, PHE51T, PHE90J, PRO98J, SER116T, SER123T, SER52J, THR126J, THR137T, THR143T, THR50T, THR52T, THR89J, TRP142T, TRP43T, TRP54T, TRP86J, TYR53J, TYR69J, TYR91J, VAL107T, VAL119T, VAL122T, VAL130T, VAL35J, VAL43J, VAL54J, VAL96J