3LUB

crystal structure of putative creatinine amidohydrolase (yp_211512.1) from bacteroides fragilis nctc 9343 at 2.11 a resolution

• Total interactions analyzed: 66
• Total true interactions: 26
• Strongest Interaction:
  • Chains: A-F
  • Int. Res.: 190
  • Norm. En. per Res.: -4.8159
• Hub Node: A(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-114.4429	-119.3249	-604.617	-838.3848	200	26	17	24803	6	46	33
A-C	0.0	0.0	-0.071	-0.071	4	0	0	31	0	2	5
A-E	0.0	0.0	-0.1063	-0.1063	4	0	0	34	0	2	5
A-F	-172.0594	-36.1257	-706.835	-915.02	190	28	36	26438	2	54	54
A-H	0.0	-8.4186	-33.9939	-42.4125	37	4	0	1936	0	28	30
B-C	-160.5442	-45.6558	-690.769	-896.969	191	30	37	26537	2	53	56
B-D	0.0	0.0	-0.1189	-0.1189	7	0	0	41	0	2	5
B-F	0.0	0.0	-0.0434	-0.0434	3	0	0	21	0	2	5
C-D	-109.1453	-121.3248	-613.628	-844.0982	205	26	17	25175	6	46	33
C-E	0.0	0.0	-0.0996	-0.0996	4	0	0	32	0	2	5
D-E	-155.9956	-41.8636	-693.34	-891.1993	192	23	38	26185	2	52	53
D-F	0.0	0.0	-0.0959	-0.0959	3	0	0	35	0	2	5
E-F	-112.672	-125.7204	-597.672	-836.0643	204	24	18	24931	5	47	34
F-I	0.0	-23.8101	-40.1232	-63.9333	35	0	0	1638	4	25	30
G-H	-116.2085	-122.8772	-605.852	-844.9377	205	29	18	25106	4	48	34
G-I	0.0	0.0	-0.0867	-0.0867	4	0	0	33	0	2	5
G-K	0.0	0.0	-0.0716	-0.0716	4	0	0	31	0	2	5
G-L	-148.4329	-30.0522	-680.392	-858.8771	190	26	35	25970	2	53	55
H-I	-175.0166	-33.4407	-698.339	-906.7963	191	25	36	26434	2	52	54
H-J	0.0	0.0	-0.097	-0.097	5	0	0	34	0	2	5
H-L	0.0	0.0	-0.0934	-0.0934	4	0	0	35	0	2	5
I-J	-127.6696	-126.9049	-606.058	-860.6325	200	22	17	25215	4	46	32
I-K	0.0	0.0	-0.0854	-0.0854	4	0	0	34	0	2	5
J-K	-159.222	-27.3482	-688.434	-875.0042	191	25	36	26415	2	52	55
J-L	0.0	0.0	-0.0868	-0.0868	6	0	0	33	0	2	5
K-L	-127.8579	-119.2995	-606.633	-853.7905	201	20	18	24944	5	46	32

Interface residues

• A-B: ALA184A, ALA184B, ALA29A, ALA29B, ALA92A, ALA92B, ALA96A, ALA96B, ARG64A, ARG64B, ARG81A, ARG81B, ARG90A, ARG90B, ASN180A, ASN180B, ASN34A, ASN34B, ASP100A, ASP100B, ASP214A, ASP214B, ASP21A, ASP21B, ASP6A, ASP6B, CYS11A, CYS11B, CYS43A, CYS43B, CYS65A, CYS65B, CYS86A, CYS86B, GLN108A, GLN108B, GLN80A, GLN80B, GLN94A, GLN94B, GLN95A, GLN95B, GLU134A, GLU177A, GLU177B, GLU17A, GLU17B, GLU183A, GLU183B, GLU31A, GLU31B, GLU4A, GLU4B, GLU82A, GLU82B, GLU99A, GLU99B, GLY109A, GLY109B, GLY13A, GLY13B, GLY216A, GLY216B, GLY74A, GLY74B, GLY79A, GLY79B, HIS106A, HIS106B, HIS162A, HIS162B, HIS175A, HIS175B, HIS33A, HIS33B, HIS36A, HIS36B, HIS47A, HIS47B, HIS76A, HIS76B, HIS88A, HIS88B, ILE101A, ILE101B, ILE23A, ILE23B, ILE24A, ILE24B, ILE44A, ILE44B, ILE87A, ILE87B, ILE97A, ILE97B, LEU105A, LEU105B, LEU113B, LEU12A, LEU12B, LEU131A, LEU131B, LEU178A, LEU178B, LEU18A, LEU18B, LEU25A, LEU25B, LEU35A, LEU35B, LEU37A, LEU37B, LEU40A, LEU40B, LEU7A, LEU7B, LEU83A, LEU83B, LEU98A, LEU98B, LYS14A, LYS14B, LYS16A, LYS16B, LYS19A, LYS19B, LYS3A, LYS3B, PHE110A, PHE110B, PHE73A, PHE73B, PHE85A, PHE85B, PRO176A, PRO176B, PRO26A, PRO26B, PRO32A, PRO32B, PRO38A, PRO38B, PRO69A, PRO69B, PRO70A, PRO70B, PRO72A, PRO72B, PRO84A, PRO84B, SER103A, SER103B, SER104A, SER104B, SER10A, SER10B, SER215A, SER215B, SER8A, SER8B, THR30A, THR30B, THR41A, THR41B, THR89A, THR89B, THR93A, THR93B, TRP208A, TRP208B, TRP27A, TRP27B, TYR135A, TYR135B, TYR20A, TYR20B, TYR39A, TYR39B, TYR91A, TYR91B, VAL102A, VAL102B, VAL107A, VAL107B, VAL15A, VAL15B, VAL179A, VAL179B, VAL213A, VAL213B, VAL22A, VAL22B, VAL5A, VAL5B, VAL67A, VAL67B, VAL71A, VAL71B, VAL9A, VAL9B
• A-C: PHE133C, SER103A, SER104A, VAL107A
• A-E: PHE133A, SER103E, SER104E, VAL107E
• A-F: ALA132A, ALA132F, ALA141A, ALA141F, ALA142A, ALA142F, ALA143A, ALA143F, ALA193A, ALA193F, ALA195A, ALA195F, ALA202A, ALA202F, ALA211A, ALA211F, ALA240A, ALA240F, ALA247A, ALA247F, ALA75A, ALA75F, ALA92A, ALA92F, ARG129A, ARG129F, ARG206A, ARG206F, ARG81A, ARG81F, ARG90A, ARG90F, ASN122A, ASN122F, ASN123A, ASN123F, ASN144A, ASN144F, ASN198A, ASN198F, ASN77A, ASN77F, ASP130A, ASP130F, ASP137A, ASP137F, ASP209A, ASP209F, ASP250A, ASP250F, CYS86A, CYS86F, GLN248A, GLN248F, GLN80A, GLN80F, GLN94A, GLN94F, GLN95A, GLN95F, GLU134A, GLU134F, GLU147A, GLU147F, GLU199A, GLU199F, GLU237A, GLU237F, GLU244A, GLU244F, GLU245A, GLU245F, GLU253A, GLU253F, GLU82A, GLU82F, GLU99A, GLU99F, GLY120A, GLY120F, GLY121A, GLY121F, GLY126A, GLY126F, GLY241A, GLY241F, GLY74A, GLY74F, GLY79A, GLY79F, HIS119A, HIS119F, HIS207A, HIS207F, HIS249A, HIS249F, HIS76A, HIS76F, HIS88A, HIS88F, ILE115A, ILE115F, ILE128A, ILE128F, ILE140A, ILE140F, ILE194A, ILE194F, ILE235A, ILE235F, LEU113A, LEU113F, LEU114A, LEU114F, LEU116A, LEU116F, LEU131A, LEU131F, LEU139A, LEU139F, LEU197A, LEU197F, LEU239A, LEU239F, LEU242A, LEU242F, LEU251A, LEU251F, LYS112A, LYS112F, LYS125A, LYS125F, LYS190A, LYS190F, LYS200A, LYS200F, LYS210A, LYS210F, LYS238A, LYS238F, PHE124A, PHE124F, PHE133A, PHE133F, PHE138A, PHE138F, PHE192A, PHE192F, PHE243A, PHE243F, PRO136A, PRO136F, PRO191A, PRO191F, PRO205A, PRO205F, PRO234A, PRO234F, PRO78A, PRO78F, SER189A, SER189F, SER196A, SER196F, THR212A, THR212F, THR89A, THR89F, THR93A, THR93F, TRP145A, TRP145F, TRP203A, TRP203F, TRP208A, TRP208F, TYR135A, TYR135F, TYR252A, TYR252F, TYR91A, TYR91F, VAL148A, VAL148F, VAL149A, VAL149F, VAL201A, VAL201F, VAL204A, VAL204F
• A-H: ARG230A, ARG230H, ARG60A, GLU156A, GLU156H, GLU158H, GLU226A, GLU226H, GLU229A, GLU237A, GLU237H, GLY153A, GLY153H, LEU56A, LYS152A, LYS152H, LYS222A, LYS222H, LYS227A, LYS227H, LYS233A, LYS233H, LYS238A, LYS238H, PHE155A, PHE155H, PRO151H, PRO234A, PRO234H, SER150H, THR224A, TYR154A, TYR154H, TYR231A, TYR231H, VAL149A, VAL149H
• B-C: ALA132B, ALA132C, ALA141B, ALA141C, ALA142B, ALA142C, ALA143B, ALA143C, ALA193B, ALA193C, ALA195B, ALA195C, ALA202B, ALA202C, ALA211B, ALA211C, ALA240B, ALA240C, ALA247B, ALA247C, ALA75B, ALA75C, ALA92B, ALA92C, ARG129B, ARG129C, ARG206B, ARG206C, ARG81B, ARG81C, ARG90B, ARG90C, ASN122B, ASN122C, ASN123B, ASN123C, ASN144B, ASN144C, ASN198B, ASN198C, ASN77B, ASN77C, ASP130B, ASP130C, ASP137B, ASP137C, ASP209B, ASP209C, ASP250B, ASP250C, CYS86B, CYS86C, GLN248B, GLN248C, GLN80B, GLN80C, GLN94B, GLN94C, GLN95B, GLN95C, GLU134B, GLU134C, GLU147B, GLU147C, GLU199B, GLU199C, GLU237B, GLU237C, GLU244B, GLU244C, GLU245B, GLU245C, GLU253B, GLU253C, GLU82B, GLU82C, GLU99B, GLU99C, GLY120B, GLY120C, GLY121B, GLY121C, GLY126B, GLY126C, GLY241B, GLY241C, GLY74B, GLY74C, GLY79B, GLY79C, HIS119B, HIS119C, HIS207B, HIS207C, HIS249B, HIS249C, HIS76B, HIS76C, HIS88B, HIS88C, ILE115B, ILE115C, ILE128B, ILE128C, ILE140B, ILE140C, ILE194B, ILE194C, ILE235B, ILE235C, LEU113B, LEU113C, LEU114B, LEU114C, LEU116B, LEU116C, LEU131B, LEU131C, LEU139B, LEU139C, LEU197B, LEU197C, LEU239B, LEU239C, LEU242B, LEU242C, LEU251B, LEU251C, LYS112B, LYS112C, LYS125B, LYS125C, LYS190B, LYS190C, LYS200B, LYS200C, LYS210B, LYS210C, LYS238B, LYS238C, PHE124B, PHE124C, PHE133B, PHE133C, PHE138B, PHE138C, PHE192B, PHE192C, PHE243B, PHE243C, PRO136B, PRO136C, PRO191B, PRO191C, PRO205B, PRO205C, PRO234B, PRO234C, PRO78B, PRO78C, SER189B, SER189C, SER196B, SER196C, THR212B, THR212C, THR89B, THR89C, THR93B, THR93C, TRP145B, TRP145C, TRP203B, TRP203C, TRP208B, TRP208C, TYR135B, TYR135C, TYR252B, TYR252C, TYR91B, TYR91C, VAL148B, VAL148C, VAL149B, VAL149C, VAL201B, VAL201C, VAL204B, VAL204C, VAL22C
• B-D: ASP100D, ASP130B, GLU134B, PHE133B, SER103D, SER104D, VAL107D
• B-F: PHE133F, SER103B, VAL107B
• C-D: ALA184C, ALA184D, ALA29C, ALA29D, ALA92C, ALA92D, ALA96C, ALA96D, ARG64C, ARG64D, ARG81C, ARG81D, ARG90C, ARG90D, ASN180C, ASN180D, ASN2D, ASN34C, ASN34D, ASP100C, ASP100D, ASP214C, ASP214D, ASP21C, ASP21D, ASP6C, ASP6D, CYS11C, CYS11D, CYS43C, CYS43D, CYS65C, CYS65D, CYS86C, CYS86D, GLN108C, GLN108D, GLN80C, GLN80D, GLN94C, GLN94D, GLN95C, GLN95D, GLU134C, GLU134D, GLU177C, GLU177D, GLU17C, GLU17D, GLU183C, GLU183D, GLU31C, GLU31D, GLU4C, GLU4D, GLU82C, GLU82D, GLU99C, GLU99D, GLY109C, GLY109D, GLY13C, GLY13D, GLY185C, GLY185D, GLY216C, GLY216D, GLY74C, GLY74D, GLY79C, GLY79D, HIS106C, HIS106D, HIS162C, HIS162D, HIS175C, HIS175D, HIS33C, HIS33D, HIS36C, HIS36D, HIS47C, HIS47D, HIS76C, HIS76D, HIS88C, HIS88D, ILE101C, ILE101D, ILE23C, ILE23D, ILE24C, ILE24D, ILE44C, ILE44D, ILE87C, ILE87D, ILE97C, ILE97D, LEU105C, LEU105D, LEU113C, LEU113D, LEU12C, LEU12D, LEU131C, LEU131D, LEU178C, LEU178D, LEU18C, LEU18D, LEU25C, LEU25D, LEU35C, LEU35D, LEU37C, LEU37D, LEU40C, LEU40D, LEU7C, LEU7D, LEU83C, LEU83D, LEU98C, LEU98D, LYS14C, LYS14D, LYS16C, LYS16D, LYS19C, LYS19D, LYS3C, LYS3D, PHE110C, PHE110D, PHE73C, PHE73D, PHE85C, PHE85D, PRO176C, PRO176D, PRO26C, PRO26D, PRO32C, PRO32D, PRO38C, PRO38D, PRO69C, PRO69D, PRO70C, PRO70D, PRO72C, PRO72D, PRO84C, PRO84D, SER103C, SER103D, SER104C, SER104D, SER10C, SER10D, SER215C, SER215D, SER8C, SER8D, THR30C, THR30D, THR41C, THR41D, THR89C, THR89D, THR93C, THR93D, TRP208C, TRP208D, TRP27C, TRP27D, TYR135C, TYR135D, TYR20C, TYR20D, TYR39C, TYR39D, TYR91C, TYR91D, VAL102C, VAL102D, VAL107C, VAL107D, VAL15C, VAL15D, VAL179C, VAL179D, VAL213C, VAL213D, VAL22C, VAL22D, VAL5C, VAL5D, VAL67C, VAL67D, VAL71C, VAL71D, VAL9C, VAL9D
• C-E: PHE133E, SER103C, SER104C, VAL107C
• D-E: ALA132D, ALA132E, ALA141D, ALA141E, ALA142D, ALA142E, ALA143D, ALA143E, ALA193D, ALA193E, ALA195D, ALA195E, ALA202D, ALA202E, ALA211D, ALA211E, ALA240D, ALA240E, ALA247D, ALA247E, ALA75D, ALA75E, ALA92D, ALA92E, ARG129D, ARG129E, ARG206D, ARG206E, ARG60D, ARG60E, ARG81D, ARG81E, ARG90D, ARG90E, ASN122D, ASN122E, ASN123D, ASN123E, ASN144D, ASN144E, ASN198D, ASN198E, ASN77D, ASN77E, ASP130D, ASP130E, ASP137D, ASP137E, ASP209D, ASP209E, ASP250D, ASP250E, CYS86D, CYS86E, GLN248D, GLN248E, GLN80D, GLN80E, GLN94D, GLN94E, GLN95D, GLN95E, GLU134D, GLU134E, GLU147D, GLU147E, GLU199D, GLU199E, GLU237D, GLU237E, GLU244D, GLU244E, GLU245D, GLU245E, GLU253D, GLU253E, GLU82D, GLU82E, GLU99D, GLU99E, GLY120D, GLY120E, GLY121D, GLY121E, GLY126D, GLY126E, GLY241D, GLY241E, GLY74D, GLY74E, GLY79D, GLY79E, HIS119D, HIS119E, HIS207D, HIS207E, HIS249D, HIS249E, HIS76D, HIS76E, HIS88D, HIS88E, ILE115D, ILE115E, ILE128D, ILE128E, ILE140D, ILE140E, ILE194D, ILE194E, ILE235D, ILE235E, LEU113D, LEU113E, LEU114D, LEU114E, LEU116D, LEU116E, LEU131D, LEU131E, LEU139D, LEU139E, LEU197D, LEU197E, LEU239D, LEU239E, LEU242D, LEU242E, LEU251D, LEU251E, LYS112D, LYS112E, LYS125D, LYS125E, LYS190D, LYS190E, LYS200D, LYS200E, LYS210D, LYS210E, LYS238D, LYS238E, PHE124D, PHE124E, PHE133D, PHE133E, PHE138D, PHE138E, PHE192D, PHE192E, PHE243D, PHE243E, PRO136D, PRO136E, PRO191D, PRO191E, PRO205D, PRO205E, PRO234D, PRO234E, PRO78D, PRO78E, SER189D, SER189E, SER196D, SER196E, THR212D, THR212E, THR89D, THR89E, THR93D, THR93E, TRP145D, TRP145E, TRP203D, TRP203E, TRP208D, TRP208E, TYR135D, TYR135E, TYR252D, TYR252E, TYR91D, TYR91E, VAL148D, VAL148E, VAL149D, VAL149E, VAL201D, VAL201E, VAL204D, VAL204E
• D-F: PHE133D, SER103F, VAL107F
• E-F: ALA184E, ALA184F, ALA29E, ALA29F, ALA92E, ALA92F, ALA96E, ALA96F, ARG64E, ARG64F, ARG81E, ARG81F, ARG90E, ARG90F, ASN180E, ASN180F, ASN2F, ASN34E, ASN34F, ASP100E, ASP100F, ASP214E, ASP214F, ASP21E, ASP21F, ASP6E, ASP6F, CYS11E, CYS11F, CYS43E, CYS43F, CYS65E, CYS65F, CYS86E, CYS86F, GLN108E, GLN108F, GLN80E, GLN80F, GLN94E, GLN94F, GLN95E, GLN95F, GLU134E, GLU134F, GLU177E, GLU177F, GLU17E, GLU17F, GLU183E, GLU183F, GLU31E, GLU31F, GLU4E, GLU4F, GLU82E, GLU82F, GLU99E, GLU99F, GLY109E, GLY109F, GLY13E, GLY13F, GLY185E, GLY216E, GLY216F, GLY74E, GLY74F, GLY79E, GLY79F, HIS106E, HIS106F, HIS162E, HIS162F, HIS175E, HIS175F, HIS33E, HIS33F, HIS36E, HIS36F, HIS47E, HIS47F, HIS76E, HIS76F, HIS88E, HIS88F, ILE101E, ILE101F, ILE23E, ILE23F, ILE24E, ILE24F, ILE44E, ILE44F, ILE87E, ILE87F, ILE97E, ILE97F, LEU105E, LEU105F, LEU113E, LEU12E, LEU12F, LEU131E, LEU131F, LEU178E, LEU178F, LEU181E, LEU18E, LEU18F, LEU25E, LEU25F, LEU35E, LEU35F, LEU37E, LEU37F, LEU40E, LEU40F, LEU7E, LEU7F, LEU83E, LEU83F, LEU98E, LEU98F, LYS14E, LYS14F, LYS16E, LYS16F, LYS19E, LYS19F, LYS3E, LYS3F, PHE110E, PHE110F, PHE73E, PHE73F, PHE85E, PHE85F, PRO176E, PRO176F, PRO26E, PRO26F, PRO32E, PRO32F, PRO38E, PRO38F, PRO69E, PRO69F, PRO70E, PRO70F, PRO72E, PRO72F, PRO84E, PRO84F, SER103E, SER103F, SER104E, SER104F, SER10E, SER10F, SER215E, SER215F, SER8E, SER8F, THR30E, THR30F, THR41E, THR41F, THR89E, THR89F, THR93E, THR93F, TRP208E, TRP208F, TRP27E, TRP27F, TYR135E, TYR135F, TYR20E, TYR20F, TYR39E, TYR39F, TYR91E, TYR91F, VAL102E, VAL102F, VAL107E, VAL107F, VAL15E, VAL15F, VAL179E, VAL179F, VAL213E, VAL213F, VAL22E, VAL22F, VAL5E, VAL5F, VAL67E, VAL67F, VAL71E, VAL71F, VAL9E, VAL9F
• F-I: ALA225I, ARG230F, ARG230I, ARG60I, GLU156F, GLU156I, GLU158F, GLU226F, GLU226I, GLU229I, GLU237I, GLY153F, GLY153I, LEU56I, LYS152F, LYS152I, LYS222F, LYS227F, LYS227I, LYS233F, LYS233I, LYS238F, LYS238I, PHE155F, PRO151F, PRO234F, PRO234I, SER150F, THR224I, TYR154F, TYR154I, TYR231F, TYR231I, VAL149F, VAL149I
• G-H: ALA184G, ALA184H, ALA29G, ALA29H, ALA92G, ALA92H, ALA96G, ALA96H, ARG64G, ARG64H, ARG81G, ARG81H, ARG90G, ARG90H, ASN180G, ASN180H, ASN2H, ASN34G, ASN34H, ASP100G, ASP100H, ASP214G, ASP214H, ASP21G, ASP21H, ASP6G, ASP6H, CYS11G, CYS11H, CYS43G, CYS43H, CYS65G, CYS65H, CYS86G, CYS86H, GLN108G, GLN108H, GLN80G, GLN80H, GLN94G, GLN94H, GLN95G, GLN95H, GLU134G, GLU134H, GLU177G, GLU177H, GLU17G, GLU17H, GLU183G, GLU183H, GLU31G, GLU31H, GLU4G, GLU4H, GLU82G, GLU82H, GLU99G, GLU99H, GLY109G, GLY109H, GLY13G, GLY13H, GLY185G, GLY185H, GLY216G, GLY216H, GLY74G, GLY74H, GLY79G, GLY79H, HIS106G, HIS106H, HIS162G, HIS162H, HIS175G, HIS175H, HIS33G, HIS33H, HIS36G, HIS36H, HIS47G, HIS47H, HIS76G, HIS76H, HIS88G, HIS88H, ILE101G, ILE101H, ILE23G, ILE23H, ILE24G, ILE24H, ILE44G, ILE44H, ILE87G, ILE87H, ILE97G, ILE97H, LEU105G, LEU105H, LEU113G, LEU113H, LEU12G, LEU12H, LEU131G, LEU131H, LEU178G, LEU178H, LEU18G, LEU18H, LEU25G, LEU25H, LEU35G, LEU35H, LEU37G, LEU37H, LEU40G, LEU40H, LEU7G, LEU7H, LEU83G, LEU83H, LEU98G, LEU98H, LYS14G, LYS14H, LYS16G, LYS16H, LYS19G, LYS19H, LYS3G, LYS3H, PHE110G, PHE110H, PHE73G, PHE73H, PHE85G, PHE85H, PRO176G, PRO176H, PRO26G, PRO26H, PRO32G, PRO32H, PRO38G, PRO38H, PRO69G, PRO69H, PRO70G, PRO70H, PRO72G, PRO72H, PRO84G, PRO84H, SER103G, SER103H, SER104G, SER104H, SER10G, SER10H, SER215G, SER215H, SER8G, SER8H, THR30G, THR30H, THR41G, THR41H, THR89G, THR89H, THR93G, THR93H, TRP208G, TRP208H, TRP27G, TRP27H, TYR135G, TYR135H, TYR20G, TYR20H, TYR39G, TYR39H, TYR91G, TYR91H, VAL102G, VAL102H, VAL107G, VAL107H, VAL15G, VAL15H, VAL179G, VAL179H, VAL213G, VAL213H, VAL22G, VAL22H, VAL5G, VAL5H, VAL67G, VAL67H, VAL71G, VAL71H, VAL9G, VAL9H
• G-I: PHE133I, SER103G, SER104G, VAL107G
• G-K: PHE133G, SER103K, SER104K, VAL107K
• G-L: ALA132G, ALA132L, ALA141G, ALA141L, ALA142G, ALA142L, ALA143G, ALA143L, ALA193G, ALA193L, ALA195G, ALA195L, ALA202G, ALA202L, ALA211G, ALA211L, ALA240G, ALA240L, ALA247G, ALA247L, ALA75G, ALA75L, ALA92G, ALA92L, ARG129G, ARG129L, ARG206G, ARG206L, ARG81G, ARG81L, ARG90G, ARG90L, ASN122G, ASN122L, ASN123G, ASN123L, ASN144G, ASN144L, ASN198G, ASN198L, ASN77G, ASN77L, ASP130G, ASP130L, ASP137G, ASP137L, ASP209G, ASP209L, ASP250G, ASP250L, CYS86G, CYS86L, GLN248G, GLN248L, GLN80G, GLN80L, GLN94G, GLN94L, GLN95G, GLN95L, GLU134G, GLU134L, GLU147G, GLU147L, GLU199G, GLU199L, GLU237G, GLU237L, GLU244G, GLU244L, GLU245G, GLU245L, GLU253G, GLU253L, GLU82G, GLU82L, GLU99G, GLU99L, GLY120G, GLY120L, GLY121G, GLY121L, GLY126G, GLY126L, GLY241G, GLY241L, GLY74G, GLY74L, GLY79G, GLY79L, HIS119G, HIS119L, HIS207G, HIS207L, HIS249G, HIS249L, HIS76G, HIS76L, HIS88G, HIS88L, ILE115G, ILE115L, ILE128G, ILE128L, ILE140G, ILE140L, ILE194G, ILE194L, ILE235G, ILE235L, LEU113G, LEU113L, LEU114G, LEU114L, LEU116G, LEU116L, LEU131G, LEU131L, LEU139G, LEU139L, LEU197G, LEU197L, LEU239G, LEU239L, LEU242G, LEU242L, LEU251G, LEU251L, LYS112G, LYS112L, LYS125G, LYS125L, LYS190G, LYS190L, LYS200G, LYS200L, LYS210G, LYS210L, LYS238G, LYS238L, PHE124G, PHE124L, PHE133G, PHE133L, PHE138G, PHE138L, PHE192G, PHE192L, PHE243G, PHE243L, PRO136G, PRO136L, PRO191G, PRO191L, PRO205G, PRO205L, PRO234G, PRO234L, PRO78G, PRO78L, SER189G, SER189L, SER196G, SER196L, THR212G, THR212L, THR89G, THR89L, THR93G, THR93L, TRP145G, TRP145L, TRP203G, TRP203L, TRP208G, TRP208L, TYR135G, TYR135L, TYR252G, TYR252L, TYR91G, TYR91L, VAL148G, VAL148L, VAL149G, VAL149L, VAL201G, VAL201L, VAL204G, VAL204L
• H-I: ALA132H, ALA132I, ALA141H, ALA141I, ALA142H, ALA142I, ALA143H, ALA143I, ALA193H, ALA193I, ALA195H, ALA195I, ALA202H, ALA202I, ALA211H, ALA211I, ALA240H, ALA240I, ALA247H, ALA247I, ALA75H, ALA75I, ALA92H, ALA92I, ARG129H, ARG129I, ARG206H, ARG206I, ARG81H, ARG81I, ARG90H, ARG90I, ASN122H, ASN122I, ASN123H, ASN123I, ASN144H, ASN144I, ASN198H, ASN198I, ASN77H, ASN77I, ASP130H, ASP130I, ASP137H, ASP137I, ASP209H, ASP209I, ASP250H, ASP250I, CYS86H, CYS86I, GLN248H, GLN248I, GLN80H, GLN80I, GLN94H, GLN94I, GLN95H, GLN95I, GLU134H, GLU134I, GLU147H, GLU147I, GLU199H, GLU199I, GLU237H, GLU237I, GLU244H, GLU244I, GLU245H, GLU245I, GLU253H, GLU253I, GLU82H, GLU82I, GLU99H, GLU99I, GLY120H, GLY120I, GLY121H, GLY121I, GLY126H, GLY126I, GLY241H, GLY241I, GLY74H, GLY74I, GLY79H, GLY79I, HIS119H, HIS119I, HIS207H, HIS207I, HIS249H, HIS249I, HIS76H, HIS76I, HIS88H, HIS88I, ILE115H, ILE115I, ILE128H, ILE128I, ILE140H, ILE140I, ILE194H, ILE194I, ILE235H, ILE235I, LEU113H, LEU113I, LEU114H, LEU114I, LEU116H, LEU116I, LEU131H, LEU131I, LEU139H, LEU139I, LEU197H, LEU197I, LEU239H, LEU239I, LEU242H, LEU242I, LEU251H, LEU251I, LYS112H, LYS112I, LYS125H, LYS125I, LYS190H, LYS190I, LYS200H, LYS200I, LYS210H, LYS210I, LYS238H, LYS238I, PHE124H, PHE124I, PHE133H, PHE133I, PHE138H, PHE138I, PHE192H, PHE192I, PHE243H, PHE243I, PRO136H, PRO136I, PRO191H, PRO191I, PRO205H, PRO205I, PRO234H, PRO234I, PRO78H, PRO78I, SER189H, SER189I, SER196H, SER196I, THR212H, THR212I, THR89H, THR89I, THR93H, THR93I, TRP145H, TRP145I, TRP203H, TRP203I, TRP208H, TRP208I, TYR135H, TYR135I, TYR252H, TYR252I, TYR91H, TYR91I, VAL148H, VAL148I, VAL149H, VAL149I, VAL201H, VAL201I, VAL204H, VAL204I, VAL22I
• H-J: ASP100J, ASP130H, PHE133H, SER103J, VAL107J
• H-L: PHE133L, SER103H, SER104H, VAL107H
• I-J: ALA184I, ALA184J, ALA29I, ALA29J, ALA92I, ALA92J, ALA96I, ALA96J, ARG64I, ARG64J, ARG81I, ARG81J, ARG90I, ARG90J, ASN180I, ASN180J, ASN2J, ASN34I, ASN34J, ASP100I, ASP100J, ASP214I, ASP214J, ASP21I, ASP21J, ASP6I, ASP6J, CYS11I, CYS11J, CYS43I, CYS43J, CYS65I, CYS65J, CYS86I, CYS86J, GLN108I, GLN108J, GLN80I, GLN80J, GLN94I, GLN94J, GLN95I, GLN95J, GLU134I, GLU177I, GLU177J, GLU17I, GLU17J, GLU183I, GLU183J, GLU31I, GLU31J, GLU4I, GLU4J, GLU82I, GLU82J, GLU99I, GLU99J, GLY109I, GLY109J, GLY13I, GLY13J, GLY216I, GLY216J, GLY74I, GLY74J, GLY79I, GLY79J, HIS106I, HIS106J, HIS162I, HIS162J, HIS175J, HIS33I, HIS33J, HIS36I, HIS36J, HIS47I, HIS47J, HIS76I, HIS76J, HIS88I, HIS88J, ILE101I, ILE101J, ILE23I, ILE23J, ILE24I, ILE24J, ILE44I, ILE44J, ILE87I, ILE87J, ILE97I, ILE97J, LEU105I, LEU105J, LEU113I, LEU12I, LEU12J, LEU131I, LEU131J, LEU178I, LEU178J, LEU18I, LEU18J, LEU25I, LEU25J, LEU35I, LEU35J, LEU37I, LEU37J, LEU40I, LEU40J, LEU7I, LEU7J, LEU83I, LEU83J, LEU98I, LEU98J, LYS14I, LYS14J, LYS16I, LYS16J, LYS19I, LYS19J, LYS3I, LYS3J, PHE110I, PHE110J, PHE73I, PHE73J, PHE85I, PHE85J, PRO176I, PRO176J, PRO26I, PRO26J, PRO32I, PRO32J, PRO38I, PRO38J, PRO69I, PRO69J, PRO70I, PRO70J, PRO72I, PRO72J, PRO84I, PRO84J, SER103I, SER103J, SER104I, SER104J, SER10I, SER10J, SER215I, SER215J, SER8I, SER8J, THR30I, THR30J, THR41I, THR41J, THR89I, THR89J, THR93I, THR93J, TRP208I, TRP208J, TRP27I, TRP27J, TYR135I, TYR135J, TYR20I, TYR20J, TYR39I, TYR39J, TYR91I, TYR91J, VAL102I, VAL102J, VAL107I, VAL107J, VAL15I, VAL15J, VAL179I, VAL179J, VAL213I, VAL213J, VAL22I, VAL22J, VAL5I, VAL5J, VAL67I, VAL67J, VAL71I, VAL71J, VAL9I, VAL9J
• I-K: GLU134K, PHE133K, SER103I, VAL107I
• J-K: ALA132J, ALA132K, ALA141J, ALA141K, ALA142J, ALA142K, ALA143J, ALA143K, ALA193J, ALA193K, ALA195J, ALA195K, ALA202J, ALA202K, ALA211J, ALA211K, ALA240J, ALA240K, ALA247J, ALA247K, ALA75J, ALA75K, ALA92J, ALA92K, ARG129J, ARG129K, ARG206J, ARG206K, ARG60J, ARG81J, ARG81K, ARG90J, ARG90K, ASN122J, ASN122K, ASN123J, ASN123K, ASN144J, ASN144K, ASN198J, ASN198K, ASN77J, ASN77K, ASP130J, ASP130K, ASP137J, ASP137K, ASP209J, ASP209K, ASP250J, ASP250K, CYS86J, CYS86K, GLN248J, GLN248K, GLN80J, GLN80K, GLN94J, GLN94K, GLN95J, GLN95K, GLU134J, GLU134K, GLU147J, GLU147K, GLU199J, GLU199K, GLU237J, GLU237K, GLU244J, GLU244K, GLU245J, GLU245K, GLU253J, GLU253K, GLU82J, GLU82K, GLU99J, GLU99K, GLY120J, GLY120K, GLY121J, GLY121K, GLY126J, GLY126K, GLY241J, GLY241K, GLY74J, GLY74K, GLY79J, GLY79K, HIS119J, HIS119K, HIS207J, HIS207K, HIS249J, HIS249K, HIS76J, HIS76K, HIS88J, HIS88K, ILE115J, ILE115K, ILE128J, ILE128K, ILE140J, ILE140K, ILE194J, ILE194K, ILE235J, ILE235K, LEU113J, LEU113K, LEU114J, LEU114K, LEU116J, LEU116K, LEU131J, LEU131K, LEU139J, LEU139K, LEU197J, LEU197K, LEU239J, LEU239K, LEU242J, LEU242K, LEU251J, LEU251K, LYS112J, LYS112K, LYS125J, LYS125K, LYS190J, LYS190K, LYS200J, LYS200K, LYS210J, LYS210K, LYS238J, LYS238K, PHE124J, PHE124K, PHE133J, PHE133K, PHE138J, PHE138K, PHE192J, PHE192K, PHE243J, PHE243K, PRO136J, PRO136K, PRO191J, PRO191K, PRO205J, PRO205K, PRO234J, PRO234K, PRO78J, PRO78K, SER189J, SER189K, SER196J, SER196K, THR212J, THR212K, THR89J, THR89K, THR93J, THR93K, TRP145J, TRP145K, TRP203J, TRP203K, TRP208J, TRP208K, TYR135J, TYR135K, TYR252J, TYR252K, TYR91J, TYR91K, VAL148J, VAL148K, VAL149J, VAL149K, VAL201J, VAL201K, VAL204J, VAL204K
• J-L: ASP100L, ASP130J, GLU134J, PHE133J, SER103L, VAL107L
• K-L: ALA184K, ALA184L, ALA29K, ALA29L, ALA92K, ALA92L, ALA96K, ALA96L, ARG64K, ARG64L, ARG81K, ARG81L, ARG90K, ARG90L, ASN180K, ASN180L, ASN34K, ASN34L, ASP100K, ASP100L, ASP214K, ASP214L, ASP21K, ASP21L, ASP6K, ASP6L, CYS11K, CYS11L, CYS43K, CYS43L, CYS65K, CYS65L, CYS86K, CYS86L, GLN108K, GLN108L, GLN80K, GLN80L, GLN94K, GLN94L, GLN95K, GLN95L, GLU134L, GLU177K, GLU177L, GLU17K, GLU17L, GLU183K, GLU183L, GLU31K, GLU31L, GLU4K, GLU4L, GLU82K, GLU82L, GLU99K, GLU99L, GLY109K, GLY109L, GLY13K, GLY13L, GLY185K, GLY216K, GLY216L, GLY74K, GLY74L, GLY79K, GLY79L, HIS106K, HIS106L, HIS162K, HIS162L, HIS175K, HIS175L, HIS33K, HIS33L, HIS36K, HIS36L, HIS47K, HIS47L, HIS76K, HIS76L, HIS88K, HIS88L, ILE101K, ILE101L, ILE23K, ILE23L, ILE24K, ILE24L, ILE44K, ILE44L, ILE87K, ILE87L, ILE97K, ILE97L, LEU105K, LEU105L, LEU113K, LEU12K, LEU12L, LEU131K, LEU131L, LEU178K, LEU178L, LEU18K, LEU18L, LEU25K, LEU25L, LEU35K, LEU35L, LEU37K, LEU37L, LEU40K, LEU40L, LEU7K, LEU7L, LEU83K, LEU83L, LEU98K, LEU98L, LYS14K, LYS14L, LYS16K, LYS16L, LYS19K, LYS19L, LYS3K, LYS3L, PHE110K, PHE110L, PHE73K, PHE73L, PHE85K, PHE85L, PRO176K, PRO176L, PRO26K, PRO26L, PRO32K, PRO32L, PRO38K, PRO38L, PRO69K, PRO69L, PRO70K, PRO70L, PRO72K, PRO72L, PRO84K, PRO84L, SER103K, SER103L, SER104K, SER104L, SER10K, SER10L, SER215K, SER215L, SER8K, SER8L, THR30K, THR30L, THR41K, THR41L, THR89K, THR89L, THR93K, THR93L, TRP208K, TRP208L, TRP27K, TRP27L, TYR135K, TYR135L, TYR20K, TYR20L, TYR39K, TYR39L, TYR91K, TYR91L, VAL102K, VAL102L, VAL107K, VAL107L, VAL15K, VAL15L, VAL179K, VAL179L, VAL213K, VAL213L, VAL22K, VAL22L, VAL5K, VAL5L, VAL67K, VAL67L, VAL71K, VAL71L, VAL9K, VAL9L