3LTF

crystal structure of the drosophila epidermal growth factor receptor ectodomain in complex with spitz

• Total interactions analyzed: 6
• Total true interactions: 3
• Strongest Interaction:
  • Chains: C-D
  • Int. Res.: 166
  • Norm. En. per Res.: -3.7641
• Hub Node: A(2)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-C	-80.7466	-52.2184	-405.645	-538.61	184	24	13	17046	9	37	43
A-B	-46.2496	-41.2951	-411.419	-498.9637	148	23	9	17100	2	37	32
C-D	-129.3995	-48.1645	-447.276	-624.8399	166	43	14	19599	5	44	36

Interface residues

• A-C: ALA191A, ALA191C, ALA258A, ALA258C, ALA261A, ALA261C, ALA277A, ALA277C, ARG194A, ARG201A, ARG201C, ARG240A, ARG240C, ARG273A, ARG273C, ARG280A, ARG280C, ARG396C, ARG81A, ARG81C, ARG83A, ARG83C, ASN225A, ASN225C, ASN243A, ASN243C, ASN275A, ASN275C, ASN297A, ASN297C, ASN36C, ASP219A, ASP274A, ASP274C, ASP285A, ASP285C, ASP325C, ASP34A, ASP34C, CYS186A, CYS186C, CYS190A, CYS190C, CYS195A, CYS203A, CYS203C, CYS204A, CYS208A, CYS232A, CYS236A, CYS236C, CYS263C, CYS267A, CYS267C, CYS278A, CYS278C, CYS282A, CYS282C, CYS293A, CYS293C, CYS296A, CYS296C, GLN189A, GLN189C, GLN217A, GLN217C, GLN284A, GLN284C, GLN397A, GLN397C, GLU202A, GLU202C, GLU234A, GLU234C, GLU235A, GLU235C, GLU250A, GLU250C, GLY192A, GLY192C, GLY193A, GLY193C, GLY214A, GLY260A, GLY260C, GLY276A, GLY276C, GLY298A, GLY298C, GLY35A, GLY35C, GLY60A, GLY60C, GLY82A, GLY82C, HIS205A, HIS205C, HIS270A, HIS270C, ILE2A, ILE2C, ILE4A, LEU206A, LEU206C, LEU249A, LEU249C, LEU271A, LEU271C, LEU272A, LEU272C, LEU85A, LYS199A, LYS199C, LYS218A, LYS224A, LYS224C, LYS233A, LYS233C, LYS241A, LYS241C, LYS286A, LYS286C, LYS7A, MET239A, MET239C, PHE207A, PHE207C, PHE226A, PHE226C, PRO188A, PRO188C, PRO198C, PRO200A, PRO200C, PRO215A, PRO215C, PRO237A, PRO238A, PRO238C, PRO244A, PRO244C, PRO268A, PRO268C, PRO283A, PRO283C, PRO295A, PRO295C, PRO299C, SER187A, SER187C, SER281A, SER281C, THR216A, THR245A, THR245C, THR246A, THR246C, THR251A, THR262A, THR262C, THR59A, THR59C, THR84A, THR84C, TYR196A, TYR242A, TYR242C, TYR247A, TYR247C, TYR257A, TYR257C, TYR259A, TYR259C, TYR32A, TYR32C, VAL248A, VAL248C, VAL264A, VAL264C, VAL279A, VAL279C, VAL294A, VAL294C, VAL33A
• A-B: ALA13B, ALA20B, ALA24B, ALA28B, ALA343A, ALA38B, ALA404A, ALA407A, ARG21A, ARG24A, ARG329A, ARG444A, ARG45B, ARG9A, ASN124A, ASN15A, ASN18B, ASN22A, ASN344A, ASN373A, ASN459A, ASN461A, ASN53B, ASP25A, ASP29B, ASP332A, ASP340A, ASP52B, CYS22B, CYS35B, CYS37B, CYS46B, CYS7B, GLN333A, GLN339A, GLN432A, GLN449A, GLN44B, GLN454A, GLU17A, GLU36B, GLU375A, GLU400A, GLU460A, GLU47B, GLU50B, GLU92A, GLY337A, GLY348A, GLY376A, GLY40B, GLY43B, HIS123A, HIS18A, HIS19A, HIS21B, HIS433A, HIS66A, ILE27B, ILE330A, ILE374A, ILE39B, ILE408A, ILE431A, ILE443A, ILE51B, LEU10A, LEU17B, LEU23A, LEU30B, LEU310A, LEU331A, LEU56B, LEU88A, LYS103A, LYS16A, LYS26B, LYS410A, LYS455A, LYS49B, LYS58B, LYS7A, MET347A, MET399A, MET402A, MET42B, PHE11B, PHE23B, PHE2B, PHE338A, PHE403A, PHE41B, PHE86A, PHE98A, PRO13A, PRO31B, PRO349A, PRO3B, PRO446A, PRO57B, SER11A, SER14A, SER336A, SER34B, SER401A, SER411A, SER412A, SER428A, SER441A, SER65A, SER89A, SER8A, THR100A, THR10B, THR308A, THR346A, THR377A, THR4B, THR54B, TRP14B, TRP41A, TRP445A, TRP457A, TYR101A, TYR126A, TYR15B, TYR20A, TYR33B, TYR342A, TYR345A, TYR351A, TYR371A, TYR48B, TYR55B, TYR5B, TYR95A, VAL12A, VAL25B, VAL307A, VAL309A, VAL32B, VAL341A, VAL409A, VAL429A, VAL430A, VAL440A, VAL456A, VAL458A
• C-D: ALA13D, ALA20D, ALA24D, ALA28D, ALA38D, ALA404C, ALA407C, ARG21C, ARG26C, ARG329C, ARG350C, ARG444C, ARG45D, ARG9C, ASN124C, ASN15C, ASN18D, ASN22C, ASN344C, ASN373C, ASN434C, ASN442C, ASN459C, ASN461C, ASN53D, ASP12D, ASP19D, ASP25C, ASP29D, ASP332C, ASP340C, ASP52D, ASP68C, CYS16D, CYS22D, CYS35D, CYS37D, CYS46D, CYS7D, GLN333C, GLN339C, GLN432C, GLN44D, GLN454C, GLU36D, GLU375C, GLU38C, GLU400C, GLU460C, GLU47D, GLU50D, GLU91C, GLU92C, GLU93C, GLU9D, GLY337C, GLY348C, GLY376C, GLY40D, GLY43D, HIS123C, HIS18C, HIS19C, HIS21D, HIS378C, HIS433C, HIS66C, ILE27D, ILE330C, ILE374C, ILE39D, ILE408C, ILE431C, ILE443C, ILE51D, LEU10C, LEU17D, LEU30D, LEU331C, LEU56D, LEU63C, LEU88C, LYS103C, LYS16C, LYS1C, LYS26D, LYS410C, LYS455C, LYS49D, LYS58D, LYS7C, MET347C, MET399C, MET402C, MET42D, PHE11D, PHE122C, PHE23D, PHE2D, PHE335C, PHE338C, PHE403C, PHE41D, PHE86C, PHE98C, PRO13C, PRO31D, PRO3D, PRO43C, PRO446C, PRO57D, PRO8D, SER102C, SER11C, SER14C, SER336C, SER34D, SER401C, SER411C, SER412C, SER428C, SER441C, SER65C, SER87C, SER89C, SER8C, THR100C, THR10D, THR308C, THR334C, THR346C, THR377C, THR40C, THR4D, THR54D, THR6C, TRP14D, TRP41C, TRP445C, TRP457C, TYR101C, TYR126C, TYR15D, TYR33D, TYR342C, TYR345C, TYR351C, TYR371C, TYR48D, TYR55D, TYR5D, TYR61C, TYR95C, VAL12C, VAL25D, VAL309C, VAL32D, VAL341C, VAL409C, VAL429C, VAL430C, VAL440C, VAL456C, VAL458C, VAL90C, VAL99C