3LOS

atomic model of mm-cpn in the closed state

• Total interactions analyzed: 120
• Total true interactions: 60
• Strongest Interaction:
  • Chains: B-C
  • Int. Res.: 259
  • Norm. En. per Res.: -2.512
• Hub Node: A(10)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-40.8947	-11.1147	-592.093	-644.1024	259	142	11	27225	8	130	133
A-C	0.0	0.0	-3.6373	-3.6373	14	0	0	425	0	2	5
A-D	0.0	0.0	-0.0265	-0.0265	3	0	0	21	0	1	1
A-E	0.0	0.0	-0.0103	-0.0103	2	0	0	8	0	0	0
A-F	0.0	0.0	-0.0102	-0.0102	3	0	0	10	0	0	1
A-G	0.0	0.0	-3.6493	-3.6493	14	0	0	426	0	2	5
A-H	-48.5651	-10.729	-590.768	-650.062	259	139	11	27208	8	130	133
A-M	0.0	0.0	-0.0009	-0.0009	2	0	0	3	0	0	0
A-N	-8.7147	9.8605			18
A-O	0.0	4.8128			2
B-C	-48.5124	-10.7565	-591.33	-650.5989	259	138	11	27203	8	130	133
B-D	0.0	0.0	-3.3557	-3.3557	14	0	0	412	0	2	5
B-E	0.0	0.0	-0.0102	-0.0102	3	0	0	10	0	0	1
B-F	0.0	0.0	-0.0011	-0.0011	2	0	0	3	0	0	0
B-G	0.0	0.0	-0.0266	-0.0266	3	0	0	21	0	1	1
B-H	0.0	0.0	-3.3645	-3.3645	14	0	0	413	0	2	5
B-O	-8.7128	9.8894			18
B-P	0.0	4.8092			2
C-D	-40.9855	-11.0726	-591.426	-643.4842	259	142	11	27232	8	130	133
C-E	0.0	0.0	-3.6262	-3.6262	14	0	0	425	0	2	5
C-F	0.0	0.0	-0.0264	-0.0264	3	0	0	21	0	1	1
C-G	0.0	0.0	-0.0103	-0.0103	2	0	0	8	0	0	0
C-H	0.0	0.0	-0.0103	-0.0103	3	0	0	10	0	0	1
C-I	0.0	4.8093	-34.5564	-29.7471	28	1	0	1279	0	10	5
C-P	-8.73	9.8758			18
D-E	-48.6211	-10.7408	-591.069	-650.4308	259	139	11	27196	8	130	133
D-F	0.0	0.0	-3.3479	-3.3479	14	0	0	412	0	2	5
D-G	0.0	0.0	-0.0102	-0.0102	3	0	0	10	0	0	1
D-H	0.0	0.0	-0.0011	-0.0011	2	0	0	3	0	0	0
D-I	-8.7322	9.8988	-140.012	-138.8455	106	2	0	6592	2	50	52
D-J	0.0	4.8093	-34.5579	-29.7486	28	1	0	1279	0	10	5
E-F	-40.9639	-11.0793	-591.386	-643.4292	259	142	11	27232	8	130	133
E-G	0.0	0.0	-3.6403	-3.6403	14	0	0	426	0	2	5
E-H	0.0	0.0	-0.0264	-0.0264	3	0	0	21	0	1	1
E-I	0.0	0.0	-14.9593	-14.9593	12	11	1	846	0	0	3
E-J	-8.73	9.8754	-140.121	-138.9756	106	2	0	6582	2	50	52
E-K	0.0	4.8093	-34.5564	-29.7471	28	1	0	1279	0	10	5
F-G	-48.631	-10.7229	-591.18	-650.5339	259	138	11	27197	8	130	133
F-H	0.0	0.0	-3.3532	-3.3532	14	0	0	412	0	2	5
F-J	0.0	0.0	-14.9593	-14.9593	12	11	1	846	0	0	3
F-K	-8.7322	9.8988	-140.012	-138.8455	106	2	0	6592	2	50	52
F-L	0.0	4.8093	-34.5579	-29.7486	28	1	0	1279	0	10	5
G-H	-40.9469	-11.0714	-591.547	-643.5653	259	142	11	27231	8	130	133
G-K	0.0	0.0	-14.9593	-14.9593	12	11	1	846	0	0	3
G-L	-8.73	9.8754	-140.121	-138.9756	106	2	0	6582	2	50	52
G-M	0.0	4.8093	-23.6354	-18.8261	23	0	0	916	0	8	4
H-L	0.0	0.0	-14.9593	-14.9593	12	11	1	846	0	0	3
H-M	-8.7322	9.8978	-100.811	-99.6454	81	1	0	4817	2	34	37
H-N	0.0	4.8102			2
I-J	-40.9698	-11.0871	-590.427	-642.4839	260	145	11	27209	8	130	133
I-K	0.0	0.0	-3.2929	-3.2929	14	0	0	407	0	2	5
I-L	0.0	0.0	-0.0229	-0.0229	3	0	0	17	0	1	1
I-P	-48.6318	-10.7368			52
J-K	-48.6318	-10.7368	-590.358	-649.7266	260	141	11	27174	8	130	133
J-L	0.0	0.0	-3.5404	-3.5404	14	0	0	420	0	2	5
K-L	-40.9698	-11.0871	-590.427	-642.4839	260	145	11	27209	8	130	133
L-M	-48.6318	-10.7368	-86.9919	-146.3605	134	16	1	5422	5	37	34
M-N	-40.9503	-11.0865			51
N-O	-48.6314	-10.7364			52
O-P	-40.9698	-11.0871			51

Interface residues

• A-B: ALA128A, ALA163B, ALA166B, ALA201B, ALA20A, ALA221B, ALA248A, ALA248B, ALA256B, ALA294B, ALA299B, ALA318A, ALA334A, ALA445B, ALA448B, ALA503A, ALA517A, ALA518A, ALA524A, ALA74A, ALA75A, ARG14A, ARG18A, ARG218B, ARG251A, ARG251B, ARG346B, ARG370B, ARG425A, ARG493A, ARG511A, ARG522A, ARG66B, ASN114A, ASN11A, ASN11B, ASN24A, ASN324A, ASN328A, ASN447B, ASN474B, ASP183A, ASP189A, ASP191A, ASP204B, ASP247A, ASP247B, ASP254A, ASP254B, ASP271A, ASP291B, ASP292B, ASP331A, ASP351B, ASP45B, ASP50B, ASP513A, ASP514A, ASP51B, ASP526A, ASP529A, ASP54B, CYS393A, GLN125A, GLN129A, GLN132A, GLN21A, GLN222B, GLN264A, GLN295B, GLN335A, GLN3B, GLN497A, GLN4B, GLN500A, GLN85A, GLU10A, GLU164B, GLU185A, GLU243A, GLU243B, GLU245A, GLU249A, GLU249B, GLU260A, GLU263B, GLU265A, GLU265B, GLU266B, GLU301B, GLU315A, GLU33B, GLU374B, GLU378B, GLU379B, GLU426A, GLU446B, GLU504A, GLU507A, GLU519A, GLU67B, GLU71A, GLU71B, GLU80A, GLU86A, GLU88A, GLY162B, GLY17A, GLY186A, GLY200B, GLY350B, GLY371B, GLY424A, GLY43B, GLY523A, GLY528A, GLY531A, GLY532A, GLY53B, GLY6B, HIS116A, HIS296B, HIS375B, HIS72A, ILE119A, ILE203B, ILE241A, ILE250A, ILE250B, ILE252A, ILE252B, ILE262A, ILE262B, ILE303B, ILE30B, ILE31B, ILE326A, ILE329A, ILE348B, ILE377B, ILE512A, ILE516A, ILE64B, LEU258A, LEU258B, LEU293B, LEU332A, LEU39B, LEU450B, LEU473B, LEU48B, LEU509A, LEU510A, LEU521A, LEU52B, LEU65B, LEU78A, LEU8B, LYS122A, LYS13A, LYS161B, LYS165B, LYS187A, LYS190A, LYS198B, LYS225B, LYS226B, LYS257A, LYS257B, LYS267A, LYS267B, LYS270B, LYS300B, LYS319A, LYS330A, LYS347B, LYS42B, LYS46B, LYS520A, LYS76A, LYS83A, LYS87A, MET12A, MET12B, MET16A, MET1B, MET223B, MET259B, MET268A, MET272A, MET353B, MET44B, MET47B, MET508A, MET527A, MET530A, MET68B, MET77A, PHE261A, PHE261B, PHE476B, PRO117A, PRO255A, PRO255B, PRO41B, PRO525A, PRO525B, PRO5B, PRO73A, PRO9B, SER199B, SER202B, SER2B, SER333A, SER349B, SER352B, SER37B, SER423A, SER501A, SER505A, SER69A, SER69B, THR118A, THR244A, THR246A, THR246B, THR253A, THR253B, THR321A, THR327A, THR34B, THR372B, THR373B, THR38B, THR496A, THR58B, THR63B, THR84A, TYR15A, TYR297B, VAL115A, VAL121A, VAL188A, VAL304B, VAL325A, VAL35B, VAL376B, VAL380B, VAL475B, VAL494A, VAL49B, VAL515A, VAL55B, VAL56B, VAL57B, VAL70A, VAL70B, VAL7B, VAL81A
• A-C: ALA248A, ARG251A, ARG251C, ASP254C, ASP51C, GLU249A, ILE250A, ILE250C, ILE252C, LEU52C, MET527A, PRO255C, THR253A, THR253C
• A-D: ILE250A, ILE250D, THR253D
• A-E: ILE250A, ILE250E
• A-F: ILE250A, ILE250F, THR253A
• A-G: ALA248G, ARG251A, ARG251G, ASP254A, ASP51A, GLU249G, ILE250A, ILE250G, ILE252A, LEU52A, MET527G, PRO255A, THR253A, THR253G
• A-H: ALA128H, ALA163A, ALA166A, ALA201A, ALA20H, ALA221A, ALA248A, ALA248H, ALA256A, ALA294A, ALA299A, ALA318H, ALA334H, ALA445A, ALA448A, ALA503H, ALA517H, ALA518H, ALA524H, ALA74H, ALA75H, ARG14H, ARG18H, ARG218A, ARG251A, ARG251H, ARG346A, ARG370A, ARG425H, ARG493H, ARG511H, ARG522H, ARG66A, ASN114H, ASN11A, ASN11H, ASN24H, ASN324H, ASN328H, ASN447A, ASN474A, ASP183H, ASP189H, ASP191H, ASP204A, ASP247A, ASP247H, ASP254A, ASP254H, ASP271H, ASP291A, ASP292A, ASP331H, ASP351A, ASP45A, ASP50A, ASP513H, ASP514H, ASP51A, ASP526H, ASP529H, ASP54A, CYS393H, GLN125H, GLN129H, GLN132H, GLN21H, GLN222A, GLN264H, GLN295A, GLN335H, GLN3A, GLN497H, GLN4A, GLN500H, GLN85H, GLU10H, GLU164A, GLU185H, GLU243A, GLU243H, GLU245H, GLU249A, GLU249H, GLU260H, GLU263A, GLU265A, GLU265H, GLU266A, GLU301A, GLU315H, GLU33A, GLU374A, GLU378A, GLU379A, GLU426H, GLU446A, GLU504H, GLU507H, GLU519H, GLU67A, GLU71A, GLU71H, GLU80H, GLU86H, GLU88H, GLY162A, GLY17H, GLY186H, GLY200A, GLY350A, GLY371A, GLY424H, GLY43A, GLY523H, GLY528H, GLY531H, GLY532H, GLY53A, GLY6A, HIS116H, HIS296A, HIS375A, HIS72H, ILE119H, ILE203A, ILE241H, ILE250A, ILE250H, ILE252A, ILE252H, ILE262A, ILE262H, ILE303A, ILE30A, ILE31A, ILE326H, ILE329H, ILE348A, ILE377A, ILE512H, ILE516H, ILE64A, LEU258A, LEU258H, LEU293A, LEU332H, LEU39A, LEU450A, LEU473A, LEU48A, LEU509H, LEU510H, LEU521H, LEU52A, LEU65A, LEU78H, LEU8A, LYS122H, LYS13H, LYS161A, LYS165A, LYS187H, LYS190H, LYS198A, LYS225A, LYS226A, LYS257A, LYS257H, LYS267A, LYS267H, LYS270A, LYS300A, LYS319H, LYS330H, LYS347A, LYS42A, LYS46A, LYS520H, LYS76H, LYS83H, LYS87H, MET12A, MET12H, MET16H, MET1A, MET223A, MET259A, MET268H, MET272H, MET353A, MET44A, MET47A, MET508H, MET527H, MET530H, MET68A, MET77H, PHE261A, PHE261H, PHE476A, PRO117H, PRO255A, PRO255H, PRO41A, PRO525A, PRO525H, PRO5A, PRO73H, PRO9A, SER199A, SER202A, SER2A, SER333H, SER349A, SER352A, SER37A, SER423H, SER501H, SER505H, SER69A, SER69H, THR118H, THR244H, THR246A, THR246H, THR253A, THR253H, THR321H, THR327H, THR34A, THR372A, THR373A, THR38A, THR496H, THR58A, THR63A, THR84H, TYR15H, TYR297A, VAL115H, VAL121H, VAL188H, VAL304A, VAL325H, VAL35A, VAL376A, VAL380A, VAL475A, VAL494H, VAL49A, VAL515H, VAL55A, VAL56A, VAL57A, VAL70A, VAL70H, VAL7A, VAL81H
• A-M: MET1A, MET1M
• A-N: ARG105A, ARG105N, ASP112A, ASP112N, ASP19A, ASP19N, ASP451A, ASP451N, GLU102A, GLU102N, GLU109A, GLU109N, HIS116A, HIS116N, LYS106A, LYS106N, MET1A, MET1N
• A-O: ARG18A, ARG18O
• B-C: ALA128B, ALA163C, ALA166C, ALA201C, ALA20B, ALA221C, ALA248B, ALA248C, ALA256C, ALA294C, ALA299C, ALA318B, ALA334B, ALA445C, ALA448C, ALA503B, ALA517B, ALA518B, ALA524B, ALA74B, ALA75B, ARG14B, ARG18B, ARG218C, ARG251B, ARG251C, ARG346C, ARG370C, ARG425B, ARG493B, ARG511B, ARG522B, ARG66C, ASN114B, ASN11B, ASN11C, ASN24B, ASN324B, ASN328B, ASN447C, ASN474C, ASP183B, ASP189B, ASP191B, ASP204C, ASP247B, ASP247C, ASP254B, ASP254C, ASP271B, ASP291C, ASP292C, ASP331B, ASP351C, ASP45C, ASP50C, ASP513B, ASP514B, ASP51C, ASP526B, ASP529B, ASP54C, CYS393B, GLN125B, GLN129B, GLN132B, GLN21B, GLN222C, GLN264B, GLN295C, GLN335B, GLN3C, GLN497B, GLN4C, GLN500B, GLN85B, GLU10B, GLU164C, GLU185B, GLU243B, GLU243C, GLU245B, GLU249B, GLU249C, GLU260B, GLU263C, GLU265B, GLU265C, GLU266C, GLU301C, GLU315B, GLU33C, GLU374C, GLU378C, GLU379C, GLU426B, GLU446C, GLU504B, GLU507B, GLU519B, GLU67C, GLU71B, GLU71C, GLU80B, GLU86B, GLU88B, GLY162C, GLY17B, GLY186B, GLY200C, GLY350C, GLY371C, GLY424B, GLY43C, GLY523B, GLY528B, GLY531B, GLY532B, GLY53C, GLY6C, HIS116B, HIS296C, HIS375C, HIS72B, ILE119B, ILE203C, ILE241B, ILE250B, ILE250C, ILE252B, ILE252C, ILE262B, ILE262C, ILE303C, ILE30C, ILE31C, ILE326B, ILE329B, ILE348C, ILE377C, ILE512B, ILE516B, ILE64C, LEU258B, LEU258C, LEU293C, LEU332B, LEU39C, LEU450C, LEU473C, LEU48C, LEU509B, LEU510B, LEU521B, LEU52C, LEU65C, LEU78B, LEU8C, LYS122B, LYS13B, LYS161C, LYS165C, LYS187B, LYS190B, LYS198C, LYS225C, LYS226C, LYS257B, LYS257C, LYS267B, LYS267C, LYS270C, LYS300C, LYS319B, LYS330B, LYS347C, LYS42C, LYS46C, LYS520B, LYS76B, LYS83B, LYS87B, MET12B, MET12C, MET16B, MET1C, MET223C, MET259C, MET268B, MET272B, MET353C, MET44C, MET47C, MET508B, MET527B, MET530B, MET68C, MET77B, PHE261B, PHE261C, PHE476C, PRO117B, PRO255B, PRO255C, PRO41C, PRO525B, PRO525C, PRO5C, PRO73B, PRO9C, SER199C, SER202C, SER2C, SER333B, SER349C, SER352C, SER37C, SER423B, SER501B, SER505B, SER69B, SER69C, THR118B, THR244B, THR246B, THR246C, THR253B, THR253C, THR321B, THR327B, THR34C, THR372C, THR373C, THR38C, THR496B, THR58C, THR63C, THR84B, TYR15B, TYR297C, VAL115B, VAL121B, VAL188B, VAL304C, VAL325B, VAL35C, VAL376C, VAL380C, VAL475C, VAL494B, VAL49C, VAL515B, VAL55C, VAL56C, VAL57C, VAL70B, VAL70C, VAL7C, VAL81B
• B-D: ALA248B, ARG251B, ARG251D, ASP254D, ASP51D, GLU249B, ILE250B, ILE250D, ILE252D, LEU52D, MET527B, PRO255D, THR253B, THR253D
• B-E: ILE250B, ILE250E, THR253E
• B-F: ILE250B, ILE250F
• B-G: ILE250B, ILE250G, THR253B
• B-H: ALA248H, ARG251B, ARG251H, ASP254B, ASP51B, GLU249H, ILE250B, ILE250H, ILE252B, LEU52B, MET527H, PRO255B, THR253B, THR253H
• B-O: ARG105B, ARG105O, ASP112B, ASP112O, ASP19B, ASP19O, ASP451B, ASP451O, GLU102B, GLU102O, GLU109B, GLU109O, HIS116B, HIS116O, LYS106B, LYS106O, MET1B, MET1O
• B-P: ARG18B, ARG18P
• C-D: ALA128C, ALA163D, ALA166D, ALA201D, ALA20C, ALA221D, ALA248C, ALA248D, ALA256D, ALA294D, ALA299D, ALA318C, ALA334C, ALA445D, ALA448D, ALA503C, ALA517C, ALA518C, ALA524C, ALA74C, ALA75C, ARG14C, ARG18C, ARG218D, ARG251C, ARG251D, ARG346D, ARG370D, ARG425C, ARG493C, ARG511C, ARG522C, ARG66D, ASN114C, ASN11C, ASN11D, ASN24C, ASN324C, ASN328C, ASN447D, ASN474D, ASP183C, ASP189C, ASP191C, ASP204D, ASP247C, ASP247D, ASP254C, ASP254D, ASP271C, ASP291D, ASP292D, ASP331C, ASP351D, ASP45D, ASP50D, ASP513C, ASP514C, ASP51D, ASP526C, ASP529C, ASP54D, CYS393C, GLN125C, GLN129C, GLN132C, GLN21C, GLN222D, GLN264C, GLN295D, GLN335C, GLN3D, GLN497C, GLN4D, GLN500C, GLN85C, GLU10C, GLU164D, GLU185C, GLU243C, GLU243D, GLU245C, GLU249C, GLU249D, GLU260C, GLU263D, GLU265C, GLU265D, GLU266D, GLU301D, GLU315C, GLU33D, GLU374D, GLU378D, GLU379D, GLU426C, GLU446D, GLU504C, GLU507C, GLU519C, GLU67D, GLU71C, GLU71D, GLU80C, GLU86C, GLU88C, GLY162D, GLY17C, GLY186C, GLY200D, GLY350D, GLY371D, GLY424C, GLY43D, GLY523C, GLY528C, GLY531C, GLY532C, GLY53D, GLY6D, HIS116C, HIS296D, HIS375D, HIS72C, ILE119C, ILE203D, ILE241C, ILE250C, ILE250D, ILE252C, ILE252D, ILE262C, ILE262D, ILE303D, ILE30D, ILE31D, ILE326C, ILE329C, ILE348D, ILE377D, ILE512C, ILE516C, ILE64D, LEU258C, LEU258D, LEU293D, LEU332C, LEU39D, LEU450D, LEU473D, LEU48D, LEU509C, LEU510C, LEU521C, LEU52D, LEU65D, LEU78C, LEU8D, LYS122C, LYS13C, LYS161D, LYS165D, LYS187C, LYS190C, LYS198D, LYS225D, LYS226D, LYS257C, LYS257D, LYS267C, LYS267D, LYS270D, LYS300D, LYS319C, LYS330C, LYS347D, LYS42D, LYS46D, LYS520C, LYS76C, LYS83C, LYS87C, MET12C, MET12D, MET16C, MET1D, MET223D, MET259D, MET268C, MET272C, MET353D, MET44D, MET47D, MET508C, MET527C, MET530C, MET68D, MET77C, PHE261C, PHE261D, PHE476D, PRO117C, PRO255C, PRO255D, PRO41D, PRO525C, PRO525D, PRO5D, PRO73C, PRO9D, SER199D, SER202D, SER2D, SER333C, SER349D, SER352D, SER37D, SER423C, SER501C, SER505C, SER69C, SER69D, THR118C, THR244C, THR246C, THR246D, THR253C, THR253D, THR321C, THR327C, THR34D, THR372D, THR373D, THR38D, THR496C, THR58D, THR63D, THR84C, TYR15C, TYR297D, VAL115C, VAL121C, VAL188C, VAL304D, VAL325C, VAL35D, VAL376D, VAL380D, VAL475D, VAL494C, VAL49D, VAL515C, VAL55D, VAL56D, VAL57D, VAL70C, VAL70D, VAL7D, VAL81C
• C-E: ALA248C, ARG251C, ARG251E, ASP254E, ASP51E, GLU249C, ILE250C, ILE250E, ILE252E, LEU52E, MET527C, PRO255E, THR253C, THR253E
• C-F: ILE250C, ILE250F, THR253F
• C-G: ILE250C, ILE250G
• C-H: ILE250C, ILE250H, THR253C
• C-I: ALA20C, ALA20I, ARG14C, ARG14I, ARG18C, ARG18I, ARG22C, ARG22I, ASP19C, ASP19I, GLN113C, GLN113I, GLU10C, GLU10I, GLY17C, GLY17I, GLY531C, GLY531I, GLY532C, GLY532I, MET16C, MET16I, MET530C, MET530I, PRO9C, PRO9I, TYR15C, TYR15I
• C-P: ARG105C, ARG105P, ASP112C, ASP112P, ASP19C, ASP19P, ASP451C, ASP451P, GLU102C, GLU102P, GLU109C, GLU109P, HIS116C, HIS116P, LYS106C, LYS106P, MET1C, MET1P
• D-E: ALA128D, ALA163E, ALA166E, ALA201E, ALA20D, ALA221E, ALA248D, ALA248E, ALA256E, ALA294E, ALA299E, ALA318D, ALA334D, ALA445E, ALA448E, ALA503D, ALA517D, ALA518D, ALA524D, ALA74D, ALA75D, ARG14D, ARG18D, ARG218E, ARG251D, ARG251E, ARG346E, ARG370E, ARG425D, ARG493D, ARG511D, ARG522D, ARG66E, ASN114D, ASN11D, ASN11E, ASN24D, ASN324D, ASN328D, ASN447E, ASN474E, ASP183D, ASP189D, ASP191D, ASP204E, ASP247D, ASP247E, ASP254D, ASP254E, ASP271D, ASP291E, ASP292E, ASP331D, ASP351E, ASP45E, ASP50E, ASP513D, ASP514D, ASP51E, ASP526D, ASP529D, ASP54E, CYS393D, GLN125D, GLN129D, GLN132D, GLN21D, GLN222E, GLN264D, GLN295E, GLN335D, GLN3E, GLN497D, GLN4E, GLN500D, GLN85D, GLU10D, GLU164E, GLU185D, GLU243D, GLU243E, GLU245D, GLU249D, GLU249E, GLU260D, GLU263E, GLU265D, GLU265E, GLU266E, GLU301E, GLU315D, GLU33E, GLU374E, GLU378E, GLU379E, GLU426D, GLU446E, GLU504D, GLU507D, GLU519D, GLU67E, GLU71D, GLU71E, GLU80D, GLU86D, GLU88D, GLY162E, GLY17D, GLY186D, GLY200E, GLY350E, GLY371E, GLY424D, GLY43E, GLY523D, GLY528D, GLY531D, GLY532D, GLY53E, GLY6E, HIS116D, HIS296E, HIS375E, HIS72D, ILE119D, ILE203E, ILE241D, ILE250D, ILE250E, ILE252D, ILE252E, ILE262D, ILE262E, ILE303E, ILE30E, ILE31E, ILE326D, ILE329D, ILE348E, ILE377E, ILE512D, ILE516D, ILE64E, LEU258D, LEU258E, LEU293E, LEU332D, LEU39E, LEU450E, LEU473E, LEU48E, LEU509D, LEU510D, LEU521D, LEU52E, LEU65E, LEU78D, LEU8E, LYS122D, LYS13D, LYS161E, LYS165E, LYS187D, LYS190D, LYS198E, LYS225E, LYS226E, LYS257D, LYS257E, LYS267D, LYS267E, LYS270E, LYS300E, LYS319D, LYS330D, LYS347E, LYS42E, LYS46E, LYS520D, LYS76D, LYS83D, LYS87D, MET12D, MET12E, MET16D, MET1E, MET223E, MET259E, MET268D, MET272D, MET353E, MET44E, MET47E, MET508D, MET527D, MET530D, MET68E, MET77D, PHE261D, PHE261E, PHE476E, PRO117D, PRO255D, PRO255E, PRO41E, PRO525D, PRO525E, PRO5E, PRO73D, PRO9E, SER199E, SER202E, SER2E, SER333D, SER349E, SER352E, SER37E, SER423D, SER501D, SER505D, SER69D, SER69E, THR118D, THR244D, THR246D, THR246E, THR253D, THR253E, THR321D, THR327D, THR34E, THR372E, THR373E, THR38E, THR496D, THR58E, THR63E, THR84D, TYR15D, TYR297E, VAL115D, VAL121D, VAL188D, VAL304E, VAL325D, VAL35E, VAL376E, VAL380E, VAL475E, VAL494D, VAL49E, VAL515D, VAL55E, VAL56E, VAL57E, VAL70D, VAL70E, VAL7E, VAL81D
• D-F: ALA248D, ARG251D, ARG251F, ASP254F, ASP51F, GLU249D, ILE250D, ILE250F, ILE252F, LEU52F, MET527D, PRO255F, THR253D, THR253F
• D-G: ILE250D, ILE250G, THR253G
• D-H: ILE250D, ILE250H
• D-I: ALA20D, ALA20I, ALA445D, ALA445I, ALA452D, ALA452I, ARG105D, ARG105I, ARG18D, ARG18I, ARG22D, ARG22I, ARG29D, ARG29I, ARG36D, ARG36I, ARG425D, ARG425I, ARG442D, ARG442I, ASN114D, ASN114I, ASN447D, ASN447I, ASP112D, ASP112I, ASP19D, ASP19I, ASP435D, ASP435I, ASP451D, ASP451I, GLN113D, GLN113I, GLN21D, GLN21I, GLN3D, GLN3I, GLN427D, GLN427I, GLN4D, GLN4I, GLU102D, GLU102I, GLU108D, GLU108I, GLU109D, GLU109I, GLU10D, GLU10I, GLU33D, GLU33I, GLU426D, GLU426I, GLU446D, GLU446I, GLU454D, GLU454I, GLY17D, GLY17I, GLY531D, GLY531I, HIS116D, HIS116I, ILE30D, ILE30I, ILE453D, ILE453I, LEU110D, LEU110I, LEU111D, LEU111I, LEU26D, LEU26I, LEU450D, LEU450I, LEU456D, LEU456I, LYS106D, LYS106I, LYS42D, LYS42I, MET16D, MET16I, MET1D, MET1I, MET23D, MET23I, PRO9D, PRO9I, SER2D, SER2I, SER37D, SER37I, THR443D, THR443I, TYR15D, TYR15I, VAL115D, VAL115I, VAL439D, VAL439I, VAL457D, VAL457I, VAL7D, VAL7I
• D-J: ALA20D, ALA20J, ARG14D, ARG14J, ARG18D, ARG18J, ARG22D, ARG22J, ASP19D, ASP19J, GLN113D, GLN113J, GLU10D, GLU10J, GLY17D, GLY17J, GLY531D, GLY531J, GLY532D, GLY532J, MET16D, MET16J, MET530D, MET530J, PRO9D, PRO9J, TYR15D, TYR15J
• E-F: ALA128E, ALA163F, ALA166F, ALA201F, ALA20E, ALA221F, ALA248E, ALA248F, ALA256F, ALA294F, ALA299F, ALA318E, ALA334E, ALA445F, ALA448F, ALA503E, ALA517E, ALA518E, ALA524E, ALA74E, ALA75E, ARG14E, ARG18E, ARG218F, ARG251E, ARG251F, ARG346F, ARG370F, ARG425E, ARG493E, ARG511E, ARG522E, ARG66F, ASN114E, ASN11E, ASN11F, ASN24E, ASN324E, ASN328E, ASN447F, ASN474F, ASP183E, ASP189E, ASP191E, ASP204F, ASP247E, ASP247F, ASP254E, ASP254F, ASP271E, ASP291F, ASP292F, ASP331E, ASP351F, ASP45F, ASP50F, ASP513E, ASP514E, ASP51F, ASP526E, ASP529E, ASP54F, CYS393E, GLN125E, GLN129E, GLN132E, GLN21E, GLN222F, GLN264E, GLN295F, GLN335E, GLN3F, GLN497E, GLN4F, GLN500E, GLN85E, GLU10E, GLU164F, GLU185E, GLU243E, GLU243F, GLU245E, GLU249E, GLU249F, GLU260E, GLU263F, GLU265E, GLU265F, GLU266F, GLU301F, GLU315E, GLU33F, GLU374F, GLU378F, GLU379F, GLU426E, GLU446F, GLU504E, GLU507E, GLU519E, GLU67F, GLU71E, GLU71F, GLU80E, GLU86E, GLU88E, GLY162F, GLY17E, GLY186E, GLY200F, GLY350F, GLY371F, GLY424E, GLY43F, GLY523E, GLY528E, GLY531E, GLY532E, GLY53F, GLY6F, HIS116E, HIS296F, HIS375F, HIS72E, ILE119E, ILE203F, ILE241E, ILE250E, ILE250F, ILE252E, ILE252F, ILE262E, ILE262F, ILE303F, ILE30F, ILE31F, ILE326E, ILE329E, ILE348F, ILE377F, ILE512E, ILE516E, ILE64F, LEU258E, LEU258F, LEU293F, LEU332E, LEU39F, LEU450F, LEU473F, LEU48F, LEU509E, LEU510E, LEU521E, LEU52F, LEU65F, LEU78E, LEU8F, LYS122E, LYS13E, LYS161F, LYS165F, LYS187E, LYS190E, LYS198F, LYS225F, LYS226F, LYS257E, LYS257F, LYS267E, LYS267F, LYS270F, LYS300F, LYS319E, LYS330E, LYS347F, LYS42F, LYS46F, LYS520E, LYS76E, LYS83E, LYS87E, MET12E, MET12F, MET16E, MET1F, MET223F, MET259F, MET268E, MET272E, MET353F, MET44F, MET47F, MET508E, MET527E, MET530E, MET68F, MET77E, PHE261E, PHE261F, PHE476F, PRO117E, PRO255E, PRO255F, PRO41F, PRO525E, PRO525F, PRO5F, PRO73E, PRO9F, SER199F, SER202F, SER2F, SER333E, SER349F, SER352F, SER37F, SER423E, SER501E, SER505E, SER69E, SER69F, THR118E, THR244E, THR246E, THR246F, THR253E, THR253F, THR321E, THR327E, THR34F, THR372F, THR373F, THR38F, THR496E, THR58F, THR63F, THR84E, TYR15E, TYR297F, VAL115E, VAL121E, VAL188E, VAL304F, VAL325E, VAL35F, VAL376F, VAL380F, VAL475F, VAL494E, VAL49F, VAL515E, VAL55F, VAL56F, VAL57F, VAL70E, VAL70F, VAL7F, VAL81E
• E-G: ALA248E, ARG251E, ARG251G, ASP254G, ASP51G, GLU249E, ILE250E, ILE250G, ILE252G, LEU52G, MET527E, PRO255G, THR253E, THR253G
• E-H: ILE250E, ILE250H, THR253H
• E-I: ALA448E, ALA448I, ASN447E, ASN447I, ASP451E, ASP451I, GLY449E, GLY449I, LEU450E, LEU450I, MET1E, MET1I
• E-J: ALA20E, ALA20J, ALA445E, ALA445J, ALA452E, ALA452J, ARG105E, ARG105J, ARG18E, ARG18J, ARG22E, ARG22J, ARG29E, ARG29J, ARG36E, ARG36J, ARG425E, ARG425J, ARG442E, ARG442J, ASN114E, ASN114J, ASN447E, ASN447J, ASP112E, ASP112J, ASP19E, ASP19J, ASP435E, ASP435J, ASP451E, ASP451J, GLN113E, GLN113J, GLN21E, GLN21J, GLN3E, GLN3J, GLN427E, GLN427J, GLN4E, GLN4J, GLU102E, GLU102J, GLU108E, GLU108J, GLU109E, GLU109J, GLU10E, GLU10J, GLU33E, GLU33J, GLU426E, GLU426J, GLU446E, GLU446J, GLU454E, GLU454J, GLY17E, GLY17J, GLY531E, GLY531J, HIS116E, HIS116J, ILE30E, ILE30J, ILE453E, ILE453J, LEU110E, LEU110J, LEU111E, LEU111J, LEU26E, LEU26J, LEU450E, LEU450J, LEU456E, LEU456J, LYS106E, LYS106J, LYS42E, LYS42J, MET16E, MET16J, MET1E, MET1J, MET23E, MET23J, PRO9E, PRO9J, SER2E, SER2J, SER37E, SER37J, THR443E, THR443J, TYR15E, TYR15J, VAL115E, VAL115J, VAL439E, VAL439J, VAL457E, VAL457J, VAL7E, VAL7J
• E-K: ALA20E, ALA20K, ARG14E, ARG14K, ARG18E, ARG18K, ARG22E, ARG22K, ASP19E, ASP19K, GLN113E, GLN113K, GLU10E, GLU10K, GLY17E, GLY17K, GLY531E, GLY531K, GLY532E, GLY532K, MET16E, MET16K, MET530E, MET530K, PRO9E, PRO9K, TYR15E, TYR15K
• F-G: ALA128F, ALA163G, ALA166G, ALA201G, ALA20F, ALA221G, ALA248F, ALA248G, ALA256G, ALA294G, ALA299G, ALA318F, ALA334F, ALA445G, ALA448G, ALA503F, ALA517F, ALA518F, ALA524F, ALA74F, ALA75F, ARG14F, ARG18F, ARG218G, ARG251F, ARG251G, ARG346G, ARG370G, ARG425F, ARG493F, ARG511F, ARG522F, ARG66G, ASN114F, ASN11F, ASN11G, ASN24F, ASN324F, ASN328F, ASN447G, ASN474G, ASP183F, ASP189F, ASP191F, ASP204G, ASP247F, ASP247G, ASP254F, ASP254G, ASP271F, ASP291G, ASP292G, ASP331F, ASP351G, ASP45G, ASP50G, ASP513F, ASP514F, ASP51G, ASP526F, ASP529F, ASP54G, CYS393F, GLN125F, GLN129F, GLN132F, GLN21F, GLN222G, GLN264F, GLN295G, GLN335F, GLN3G, GLN497F, GLN4G, GLN500F, GLN85F, GLU10F, GLU164G, GLU185F, GLU243F, GLU243G, GLU245F, GLU249F, GLU249G, GLU260F, GLU263G, GLU265F, GLU265G, GLU266G, GLU301G, GLU315F, GLU33G, GLU374G, GLU378G, GLU379G, GLU426F, GLU446G, GLU504F, GLU507F, GLU519F, GLU67G, GLU71F, GLU71G, GLU80F, GLU86F, GLU88F, GLY162G, GLY17F, GLY186F, GLY200G, GLY350G, GLY371G, GLY424F, GLY43G, GLY523F, GLY528F, GLY531F, GLY532F, GLY53G, GLY6G, HIS116F, HIS296G, HIS375G, HIS72F, ILE119F, ILE203G, ILE241F, ILE250F, ILE250G, ILE252F, ILE252G, ILE262F, ILE262G, ILE303G, ILE30G, ILE31G, ILE326F, ILE329F, ILE348G, ILE377G, ILE512F, ILE516F, ILE64G, LEU258F, LEU258G, LEU293G, LEU332F, LEU39G, LEU450G, LEU473G, LEU48G, LEU509F, LEU510F, LEU521F, LEU52G, LEU65G, LEU78F, LEU8G, LYS122F, LYS13F, LYS161G, LYS165G, LYS187F, LYS190F, LYS198G, LYS225G, LYS226G, LYS257F, LYS257G, LYS267F, LYS267G, LYS270G, LYS300G, LYS319F, LYS330F, LYS347G, LYS42G, LYS46G, LYS520F, LYS76F, LYS83F, LYS87F, MET12F, MET12G, MET16F, MET1G, MET223G, MET259G, MET268F, MET272F, MET353G, MET44G, MET47G, MET508F, MET527F, MET530F, MET68G, MET77F, PHE261F, PHE261G, PHE476G, PRO117F, PRO255F, PRO255G, PRO41G, PRO525F, PRO525G, PRO5G, PRO73F, PRO9G, SER199G, SER202G, SER2G, SER333F, SER349G, SER352G, SER37G, SER423F, SER501F, SER505F, SER69F, SER69G, THR118F, THR244F, THR246F, THR246G, THR253F, THR253G, THR321F, THR327F, THR34G, THR372G, THR373G, THR38G, THR496F, THR58G, THR63G, THR84F, TYR15F, TYR297G, VAL115F, VAL121F, VAL188F, VAL304G, VAL325F, VAL35G, VAL376G, VAL380G, VAL475G, VAL494F, VAL49G, VAL515F, VAL55G, VAL56G, VAL57G, VAL70F, VAL70G, VAL7G, VAL81F
• F-H: ALA248F, ARG251F, ARG251H, ASP254H, ASP51H, GLU249F, ILE250F, ILE250H, ILE252H, LEU52H, MET527F, PRO255H, THR253F, THR253H
• F-J: ALA448F, ALA448J, ASN447F, ASN447J, ASP451F, ASP451J, GLY449F, GLY449J, LEU450F, LEU450J, MET1F, MET1J
• F-K: ALA20F, ALA20K, ALA445F, ALA445K, ALA452F, ALA452K, ARG105F, ARG105K, ARG18F, ARG18K, ARG22F, ARG22K, ARG29F, ARG29K, ARG36F, ARG36K, ARG425F, ARG425K, ARG442F, ARG442K, ASN114F, ASN114K, ASN447F, ASN447K, ASP112F, ASP112K, ASP19F, ASP19K, ASP435F, ASP435K, ASP451F, ASP451K, GLN113F, GLN113K, GLN21F, GLN21K, GLN3F, GLN3K, GLN427F, GLN427K, GLN4F, GLN4K, GLU102F, GLU102K, GLU108F, GLU108K, GLU109F, GLU109K, GLU10F, GLU10K, GLU33F, GLU33K, GLU426F, GLU426K, GLU446F, GLU446K, GLU454F, GLU454K, GLY17F, GLY17K, GLY531F, GLY531K, HIS116F, HIS116K, ILE30F, ILE30K, ILE453F, ILE453K, LEU110F, LEU110K, LEU111F, LEU111K, LEU26F, LEU26K, LEU450F, LEU450K, LEU456F, LEU456K, LYS106F, LYS106K, LYS42F, LYS42K, MET16F, MET16K, MET1F, MET1K, MET23F, MET23K, PRO9F, PRO9K, SER2F, SER2K, SER37F, SER37K, THR443F, THR443K, TYR15F, TYR15K, VAL115F, VAL115K, VAL439F, VAL439K, VAL457F, VAL457K, VAL7F, VAL7K
• F-L: ALA20F, ALA20L, ARG14F, ARG14L, ARG18F, ARG18L, ARG22F, ARG22L, ASP19F, ASP19L, GLN113F, GLN113L, GLU10F, GLU10L, GLY17F, GLY17L, GLY531F, GLY531L, GLY532F, GLY532L, MET16F, MET16L, MET530F, MET530L, PRO9F, PRO9L, TYR15F, TYR15L
• G-H: ALA128G, ALA163H, ALA166H, ALA201H, ALA20G, ALA221H, ALA248G, ALA248H, ALA256H, ALA294H, ALA299H, ALA318G, ALA334G, ALA445H, ALA448H, ALA503G, ALA517G, ALA518G, ALA524G, ALA74G, ALA75G, ARG14G, ARG18G, ARG218H, ARG251G, ARG251H, ARG346H, ARG370H, ARG425G, ARG493G, ARG511G, ARG522G, ARG66H, ASN114G, ASN11G, ASN11H, ASN24G, ASN324G, ASN328G, ASN447H, ASN474H, ASP183G, ASP189G, ASP191G, ASP204H, ASP247G, ASP247H, ASP254G, ASP254H, ASP271G, ASP291H, ASP292H, ASP331G, ASP351H, ASP45H, ASP50H, ASP513G, ASP514G, ASP51H, ASP526G, ASP529G, ASP54H, CYS393G, GLN125G, GLN129G, GLN132G, GLN21G, GLN222H, GLN264G, GLN295H, GLN335G, GLN3H, GLN497G, GLN4H, GLN500G, GLN85G, GLU10G, GLU164H, GLU185G, GLU243G, GLU243H, GLU245G, GLU249G, GLU249H, GLU260G, GLU263H, GLU265G, GLU265H, GLU266H, GLU301H, GLU315G, GLU33H, GLU374H, GLU378H, GLU379H, GLU426G, GLU446H, GLU504G, GLU507G, GLU519G, GLU67H, GLU71G, GLU71H, GLU80G, GLU86G, GLU88G, GLY162H, GLY17G, GLY186G, GLY200H, GLY350H, GLY371H, GLY424G, GLY43H, GLY523G, GLY528G, GLY531G, GLY532G, GLY53H, GLY6H, HIS116G, HIS296H, HIS375H, HIS72G, ILE119G, ILE203H, ILE241G, ILE250G, ILE250H, ILE252G, ILE252H, ILE262G, ILE262H, ILE303H, ILE30H, ILE31H, ILE326G, ILE329G, ILE348H, ILE377H, ILE512G, ILE516G, ILE64H, LEU258G, LEU258H, LEU293H, LEU332G, LEU39H, LEU450H, LEU473H, LEU48H, LEU509G, LEU510G, LEU521G, LEU52H, LEU65H, LEU78G, LEU8H, LYS122G, LYS13G, LYS161H, LYS165H, LYS187G, LYS190G, LYS198H, LYS225H, LYS226H, LYS257G, LYS257H, LYS267G, LYS267H, LYS270H, LYS300H, LYS319G, LYS330G, LYS347H, LYS42H, LYS46H, LYS520G, LYS76G, LYS83G, LYS87G, MET12G, MET12H, MET16G, MET1H, MET223H, MET259H, MET268G, MET272G, MET353H, MET44H, MET47H, MET508G, MET527G, MET530G, MET68H, MET77G, PHE261G, PHE261H, PHE476H, PRO117G, PRO255G, PRO255H, PRO41H, PRO525G, PRO525H, PRO5H, PRO73G, PRO9H, SER199H, SER202H, SER2H, SER333G, SER349H, SER352H, SER37H, SER423G, SER501G, SER505G, SER69G, SER69H, THR118G, THR244G, THR246G, THR246H, THR253G, THR253H, THR321G, THR327G, THR34H, THR372H, THR373H, THR38H, THR496G, THR58H, THR63H, THR84G, TYR15G, TYR297H, VAL115G, VAL121G, VAL188G, VAL304H, VAL325G, VAL35H, VAL376H, VAL380H, VAL475H, VAL494G, VAL49H, VAL515G, VAL55H, VAL56H, VAL57H, VAL70G, VAL70H, VAL7H, VAL81G
• G-K: ALA448G, ALA448K, ASN447G, ASN447K, ASP451G, ASP451K, GLY449G, GLY449K, LEU450G, LEU450K, MET1G, MET1K
• G-L: ALA20G, ALA20L, ALA445G, ALA445L, ALA452G, ALA452L, ARG105G, ARG105L, ARG18G, ARG18L, ARG22G, ARG22L, ARG29G, ARG29L, ARG36G, ARG36L, ARG425G, ARG425L, ARG442G, ARG442L, ASN114G, ASN114L, ASN447G, ASN447L, ASP112G, ASP112L, ASP19G, ASP19L, ASP435G, ASP435L, ASP451G, ASP451L, GLN113G, GLN113L, GLN21G, GLN21L, GLN3G, GLN3L, GLN427G, GLN427L, GLN4G, GLN4L, GLU102G, GLU102L, GLU108G, GLU108L, GLU109G, GLU109L, GLU10G, GLU10L, GLU33G, GLU33L, GLU426G, GLU426L, GLU446G, GLU446L, GLU454G, GLU454L, GLY17G, GLY17L, GLY531G, GLY531L, HIS116G, HIS116L, ILE30G, ILE30L, ILE453G, ILE453L, LEU110G, LEU110L, LEU111G, LEU111L, LEU26G, LEU26L, LEU450G, LEU450L, LEU456G, LEU456L, LYS106G, LYS106L, LYS42G, LYS42L, MET16G, MET16L, MET1G, MET1L, MET23G, MET23L, PRO9G, PRO9L, SER2G, SER2L, SER37G, SER37L, THR443G, THR443L, TYR15G, TYR15L, VAL115G, VAL115L, VAL439G, VAL439L, VAL457G, VAL457L, VAL7G, VAL7L
• G-M: ALA20G, ALA20M, ARG14G, ARG14M, ARG18G, ARG18M, ARG22G, ARG22M, ASP19G, ASP19M, GLN113G, GLN113M, GLU10M, GLY17G, GLY17M, GLY531G, GLY532G, MET16G, MET16M, MET530G, PRO9M, TYR15G, TYR15M
• H-L: ALA448H, ALA448L, ASN447H, ASN447L, ASP451H, ASP451L, GLY449H, GLY449L, LEU450H, LEU450L, MET1H, MET1L
• H-M: ALA20H, ALA20M, ALA445H, ALA452H, ARG105H, ARG105M, ARG18H, ARG18M, ARG22H, ARG22M, ARG29H, ARG29M, ARG36H, ARG36M, ARG442H, ASN114M, ASN447H, ASP112H, ASP112M, ASP19H, ASP19M, ASP435H, ASP451H, ASP451M, GLN113H, GLN113M, GLN21H, GLN21M, GLN3H, GLN3M, GLN4H, GLN4M, GLU102H, GLU102M, GLU108H, GLU108M, GLU109H, GLU109M, GLU10H, GLU10M, GLU33H, GLU33M, GLU446H, GLU454H, GLY17H, GLY17M, GLY531H, HIS116H, HIS116M, ILE30H, ILE30M, ILE453H, LEU110H, LEU110M, LEU111M, LEU26H, LEU26M, LEU450H, LYS106H, LYS106M, LYS42H, LYS42M, MET16H, MET16M, MET1H, MET1M, MET23H, MET23M, PRO9H, PRO9M, SER2H, SER2M, SER37H, SER37M, THR443H, TYR15H, TYR15M, VAL115M, VAL439H, VAL7H, VAL7M
• H-N: ARG18H, ARG18N
• I-J: ALA128J, ALA163I, ALA166I, ALA201I, ALA20J, ALA221I, ALA248I, ALA248J, ALA256I, ALA294I, ALA299I, ALA318J, ALA334J, ALA445I, ALA448I, ALA503J, ALA517J, ALA518J, ALA524J, ALA74J, ALA75J, ARG14J, ARG18J, ARG218I, ARG251I, ARG251J, ARG346I, ARG370I, ARG425J, ARG493J, ARG511J, ARG522J, ARG66I, ASN114J, ASN11I, ASN11J, ASN24J, ASN324J, ASN328J, ASN447I, ASN474I, ASP183J, ASP189J, ASP191J, ASP204I, ASP247I, ASP247J, ASP254I, ASP254J, ASP271J, ASP291I, ASP292I, ASP331J, ASP351I, ASP45I, ASP50I, ASP513J, ASP514J, ASP51I, ASP526J, ASP529J, ASP54I, CYS393J, GLN125J, GLN129J, GLN132J, GLN21J, GLN222I, GLN264J, GLN295I, GLN335J, GLN3I, GLN497J, GLN4I, GLN500J, GLN85J, GLU10J, GLU164I, GLU185J, GLU243I, GLU243J, GLU245J, GLU249I, GLU249J, GLU260J, GLU263I, GLU265I, GLU265J, GLU266I, GLU301I, GLU315J, GLU33I, GLU374I, GLU378I, GLU379I, GLU426J, GLU446I, GLU504J, GLU507J, GLU519J, GLU67I, GLU71I, GLU71J, GLU80J, GLU86J, GLU88J, GLY162I, GLY17J, GLY186J, GLY200I, GLY350I, GLY371I, GLY424J, GLY43I, GLY523J, GLY528J, GLY531J, GLY532J, GLY53I, GLY6I, HIS116J, HIS296I, HIS375I, HIS72J, ILE119J, ILE203I, ILE241J, ILE250I, ILE250J, ILE252I, ILE252J, ILE262I, ILE262J, ILE303I, ILE30I, ILE31I, ILE326J, ILE329J, ILE348I, ILE377I, ILE512J, ILE516J, ILE64I, LEU258I, LEU258J, LEU293I, LEU332J, LEU39I, LEU450I, LEU473I, LEU48I, LEU509J, LEU510J, LEU521J, LEU52I, LEU65I, LEU78J, LEU8I, LYS122J, LYS13J, LYS161I, LYS165I, LYS187J, LYS190J, LYS198I, LYS225I, LYS226I, LYS257I, LYS257J, LYS267I, LYS267J, LYS270I, LYS300I, LYS319J, LYS330J, LYS347I, LYS42I, LYS46I, LYS520J, LYS76J, LYS83J, LYS87J, MET12I, MET12J, MET16J, MET1I, MET223I, MET259I, MET268J, MET272J, MET353I, MET44I, MET47I, MET508J, MET527J, MET530J, MET68I, MET77J, PHE261I, PHE261J, PHE476I, PRO117J, PRO255I, PRO255J, PRO41I, PRO525I, PRO525J, PRO5I, PRO73J, PRO9I, SER199I, SER202I, SER2I, SER333J, SER349I, SER352I, SER37I, SER423J, SER501J, SER505J, SER69I, SER69J, THR118J, THR244I, THR244J, THR246I, THR246J, THR253I, THR253J, THR321J, THR327J, THR34I, THR372I, THR373I, THR38I, THR496J, THR58I, THR63I, THR84J, TYR15J, TYR297I, VAL115J, VAL121J, VAL188J, VAL304I, VAL325J, VAL35I, VAL376I, VAL380I, VAL475I, VAL494J, VAL49I, VAL515J, VAL55I, VAL56I, VAL57I, VAL70I, VAL70J, VAL7I, VAL81J
• I-K: ALA248K, ARG251I, ARG251K, ASP254I, ASP51I, GLU249K, ILE250I, ILE250K, ILE252I, LEU52I, MET527K, PRO255I, THR253I, THR253K
• I-L: ILE250I, ILE250L, THR253I
• I-P: ARG251I, ARG251P, ARG346P, ARG511I, ARG522I, ARG66P, ASP191I, ASP247I, ASP247P, ASP254I, ASP254P, ASP45P, ASP50P, ASP513I, ASP514I, ASP51P, ASP526I, ASP54P, GLU164P, GLU185I, GLU243P, GLU245I, GLU249I, GLU249P, GLU263P, GLU265P, GLU266P, GLU374P, GLU446P, GLU504I, GLU507I, GLU519I, GLU67P, GLU71P, GLU80I, HIS116I, HIS375P, ILE250I, ILE252I, LYS13I, LYS187I, LYS225P, LYS330I, LYS347P, LYS46P, LYS520I, LYS76I, LYS83I, MET47P, THR253I, THR253P, VAL49P
• J-K: ALA128K, ALA163J, ALA166J, ALA201J, ALA20K, ALA221J, ALA248J, ALA248K, ALA256J, ALA294J, ALA299J, ALA318K, ALA334K, ALA445J, ALA448J, ALA503K, ALA517K, ALA518K, ALA524K, ALA74K, ALA75K, ARG14K, ARG18K, ARG218J, ARG251J, ARG251K, ARG346J, ARG370J, ARG425K, ARG493K, ARG511K, ARG522K, ARG66J, ASN114K, ASN11J, ASN11K, ASN24K, ASN324K, ASN328K, ASN447J, ASN474J, ASP183K, ASP189K, ASP191K, ASP204J, ASP247J, ASP247K, ASP254J, ASP254K, ASP271K, ASP291J, ASP292J, ASP331K, ASP351J, ASP45J, ASP50J, ASP513K, ASP514K, ASP51J, ASP526K, ASP529K, ASP54J, CYS393K, GLN125K, GLN129K, GLN132K, GLN21K, GLN222J, GLN264K, GLN295J, GLN335K, GLN3J, GLN497K, GLN4J, GLN500K, GLN85K, GLU10K, GLU164J, GLU185K, GLU243J, GLU243K, GLU245K, GLU249J, GLU249K, GLU260K, GLU263J, GLU265J, GLU265K, GLU266J, GLU301J, GLU315K, GLU33J, GLU374J, GLU378J, GLU379J, GLU426K, GLU446J, GLU504K, GLU507K, GLU519K, GLU67J, GLU71J, GLU71K, GLU80K, GLU86K, GLU88K, GLY162J, GLY17K, GLY186K, GLY200J, GLY350J, GLY371J, GLY424K, GLY43J, GLY523K, GLY528K, GLY531K, GLY532K, GLY53J, GLY6J, HIS116K, HIS296J, HIS375J, HIS72K, ILE119K, ILE203J, ILE241K, ILE250J, ILE250K, ILE252J, ILE252K, ILE262J, ILE262K, ILE303J, ILE30J, ILE31J, ILE326K, ILE329K, ILE348J, ILE377J, ILE512K, ILE516K, ILE64J, LEU258J, LEU258K, LEU293J, LEU332K, LEU39J, LEU450J, LEU473J, LEU48J, LEU509K, LEU510K, LEU521K, LEU52J, LEU65J, LEU78K, LEU8J, LYS122K, LYS13K, LYS161J, LYS165J, LYS187K, LYS190K, LYS198J, LYS225J, LYS226J, LYS257J, LYS257K, LYS267J, LYS267K, LYS270J, LYS300J, LYS319K, LYS330K, LYS347J, LYS42J, LYS46J, LYS520K, LYS76K, LYS83K, LYS87K, MET12J, MET12K, MET16K, MET1J, MET223J, MET259J, MET268K, MET272K, MET353J, MET44J, MET47J, MET508K, MET527K, MET530K, MET68J, MET77K, PHE261J, PHE261K, PHE476J, PRO117K, PRO255J, PRO255K, PRO41J, PRO525J, PRO525K, PRO5J, PRO73K, PRO9J, SER199J, SER202J, SER2J, SER333K, SER349J, SER352J, SER37J, SER423K, SER501K, SER505K, SER69J, SER69K, THR118K, THR244J, THR244K, THR246J, THR246K, THR253J, THR253K, THR321K, THR327K, THR34J, THR372J, THR373J, THR38J, THR496K, THR58J, THR63J, THR84K, TYR15K, TYR297J, VAL115K, VAL121K, VAL188K, VAL304J, VAL325K, VAL35J, VAL376J, VAL380J, VAL475J, VAL494K, VAL49J, VAL515K, VAL55J, VAL56J, VAL57J, VAL70J, VAL70K, VAL7J, VAL81K
• J-L: ALA248L, ARG251J, ARG251L, ASP254J, ASP51J, GLU249L, ILE250J, ILE250L, ILE252J, LEU52J, MET527L, PRO255J, THR253J, THR253L
• K-L: ALA128L, ALA163K, ALA166K, ALA201K, ALA20L, ALA221K, ALA248K, ALA248L, ALA256K, ALA294K, ALA299K, ALA318L, ALA334L, ALA445K, ALA448K, ALA503L, ALA517L, ALA518L, ALA524L, ALA74L, ALA75L, ARG14L, ARG18L, ARG218K, ARG251K, ARG251L, ARG346K, ARG370K, ARG425L, ARG493L, ARG511L, ARG522L, ARG66K, ASN114L, ASN11K, ASN11L, ASN24L, ASN324L, ASN328L, ASN447K, ASN474K, ASP183L, ASP189L, ASP191L, ASP204K, ASP247K, ASP247L, ASP254K, ASP254L, ASP271L, ASP291K, ASP292K, ASP331L, ASP351K, ASP45K, ASP50K, ASP513L, ASP514L, ASP51K, ASP526L, ASP529L, ASP54K, CYS393L, GLN125L, GLN129L, GLN132L, GLN21L, GLN222K, GLN264L, GLN295K, GLN335L, GLN3K, GLN497L, GLN4K, GLN500L, GLN85L, GLU10L, GLU164K, GLU185L, GLU243K, GLU243L, GLU245L, GLU249K, GLU249L, GLU260L, GLU263K, GLU265K, GLU265L, GLU266K, GLU301K, GLU315L, GLU33K, GLU374K, GLU378K, GLU379K, GLU426L, GLU446K, GLU504L, GLU507L, GLU519L, GLU67K, GLU71K, GLU71L, GLU80L, GLU86L, GLU88L, GLY162K, GLY17L, GLY186L, GLY200K, GLY350K, GLY371K, GLY424L, GLY43K, GLY523L, GLY528L, GLY531L, GLY532L, GLY53K, GLY6K, HIS116L, HIS296K, HIS375K, HIS72L, ILE119L, ILE203K, ILE241L, ILE250K, ILE250L, ILE252K, ILE252L, ILE262K, ILE262L, ILE303K, ILE30K, ILE31K, ILE326L, ILE329L, ILE348K, ILE377K, ILE512L, ILE516L, ILE64K, LEU258K, LEU258L, LEU293K, LEU332L, LEU39K, LEU450K, LEU473K, LEU48K, LEU509L, LEU510L, LEU521L, LEU52K, LEU65K, LEU78L, LEU8K, LYS122L, LYS13L, LYS161K, LYS165K, LYS187L, LYS190L, LYS198K, LYS225K, LYS226K, LYS257K, LYS257L, LYS267K, LYS267L, LYS270K, LYS300K, LYS319L, LYS330L, LYS347K, LYS42K, LYS46K, LYS520L, LYS76L, LYS83L, LYS87L, MET12K, MET12L, MET16L, MET1K, MET223K, MET259K, MET268L, MET272L, MET353K, MET44K, MET47K, MET508L, MET527L, MET530L, MET68K, MET77L, PHE261K, PHE261L, PHE476K, PRO117L, PRO255K, PRO255L, PRO41K, PRO525K, PRO525L, PRO5K, PRO73L, PRO9K, SER199K, SER202K, SER2K, SER333L, SER349K, SER352K, SER37K, SER423L, SER501L, SER505L, SER69K, SER69L, THR118L, THR244K, THR244L, THR246K, THR246L, THR253K, THR253L, THR321L, THR327L, THR34K, THR372K, THR373K, THR38K, THR496L, THR58K, THR63K, THR84L, TYR15L, TYR297K, VAL115L, VAL121L, VAL188L, VAL304K, VAL325L, VAL35K, VAL376K, VAL380K, VAL475K, VAL494L, VAL49K, VAL515L, VAL55K, VAL56K, VAL57K, VAL70K, VAL70L, VAL7K, VAL81L
• L-M: ALA128M, ALA163L, ALA166L, ALA201L, ALA20M, ALA445L, ALA448L, ALA74M, ALA75M, ARG14M, ARG18M, ARG251L, ARG251M, ARG346L, ARG370L, ARG511M, ARG522M, ARG66L, ASN114M, ASN11M, ASN24M, ASN447L, ASN474L, ASP191M, ASP204L, ASP247L, ASP247M, ASP254L, ASP254M, ASP351L, ASP45L, ASP50L, ASP513M, ASP514M, ASP51L, ASP526M, ASP54L, GLN125M, GLN129M, GLN132M, GLN21M, GLN3L, GLN4L, GLN85M, GLU10M, GLU164L, GLU185M, GLU243L, GLU245M, GLU249L, GLU249M, GLU263L, GLU265L, GLU266L, GLU33L, GLU374L, GLU446L, GLU504M, GLU507M, GLU519M, GLU67L, GLU71L, GLU71M, GLU80M, GLU86M, GLU88M, GLY162L, GLY17M, GLY200L, GLY350L, GLY53L, HIS116M, HIS375L, HIS72M, ILE119M, ILE203L, ILE250M, ILE252M, ILE30L, ILE377L, LEU450L, LEU473L, LEU48L, LEU52L, LEU78M, LEU8L, LYS122M, LYS13M, LYS161L, LYS165L, LYS187M, LYS198L, LYS225L, LYS330M, LYS347L, LYS42L, LYS46L, LYS520M, LYS76M, LYS83M, LYS87M, MET12M, MET16M, MET1L, MET44L, MET47L, MET77M, PRO117M, PRO5L, PRO73M, SER199L, SER202L, SER2L, SER349L, SER37L, SER69M, THR118M, THR253L, THR253M, THR34L, THR372L, THR373L, THR38L, THR84M, TYR15M, VAL115M, VAL121M, VAL376L, VAL475L, VAL49L, VAL55L, VAL56L, VAL70M, VAL81M
• M-N: ARG251M, ARG251N, ARG346M, ARG511N, ARG522N, ARG66M, ASP191N, ASP247M, ASP247N, ASP254M, ASP254N, ASP45M, ASP50M, ASP513N, ASP514N, ASP51M, ASP526N, ASP54M, GLU164M, GLU185N, GLU243M, GLU245N, GLU249M, GLU249N, GLU263M, GLU265M, GLU266M, GLU374M, GLU446M, GLU504N, GLU507N, GLU519N, GLU67M, GLU71M, GLU80N, HIS116N, HIS375M, ILE250N, ILE252N, LYS13N, LYS187N, LYS225M, LYS330N, LYS347M, LYS46M, LYS520N, LYS76N, LYS83N, MET47M, THR253M, VAL49M
• N-O: ARG251N, ARG251O, ARG346N, ARG511O, ARG522O, ARG66N, ASP191O, ASP247N, ASP247O, ASP254N, ASP254O, ASP45N, ASP50N, ASP513O, ASP514O, ASP51N, ASP526O, ASP54N, GLU164N, GLU185O, GLU243N, GLU245O, GLU249N, GLU249O, GLU263N, GLU265N, GLU266N, GLU374N, GLU446N, GLU504O, GLU507O, GLU519O, GLU67N, GLU71N, GLU80O, HIS116O, HIS375N, ILE250O, ILE252O, LYS13O, LYS187O, LYS225N, LYS330O, LYS347N, LYS46N, LYS520O, LYS76O, LYS83O, MET47N, THR253N, THR253O, VAL49N
• O-P: ARG251O, ARG251P, ARG346O, ARG511P, ARG522P, ARG66O, ASP191P, ASP247O, ASP247P, ASP254O, ASP254P, ASP45O, ASP50O, ASP513P, ASP514P, ASP51O, ASP526P, ASP54O, GLU164O, GLU185P, GLU243O, GLU245P, GLU249O, GLU249P, GLU263O, GLU265O, GLU266O, GLU374O, GLU446O, GLU504P, GLU507P, GLU519P, GLU67O, GLU71O, GLU80P, HIS116P, HIS375O, ILE250P, ILE252P, LYS13P, LYS187P, LYS225O, LYS330P, LYS347O, LYS46O, LYS520P, LYS76P, LYS83P, MET47O, THR253O, VAL49O