3LK4

crystal structure of capz bound to the uncapping motif from cd2ap

• Total interactions analyzed: 630
• Total true interactions: 84
• Strongest Interaction:
  • Chains: Q-R
  • Int. Res.: 93
  • Norm. En. per Res.: -6.2769
• Hub Node: A(6)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-229.6242	-92.6564	-1077.08	-1399.3606	256	53	26	43328	7	74	63
A-C	-22.134	-57.0068	-135.597	-214.7378	55	18	4	5490	5	15	10
A-E	-7.6126	0.0	-15.069	-22.6816	30	10	0	1416	0	9	6
A-F	0.0	0.0	-10.2082	-10.2082	22	0	0	916	0	1	1
A-J	-29.2659	-13.217	-82.1866	-124.6695	39	5	0	2854	0	15	15
A-K	-7.5993	25.9373	-13.4158	4.9222	10	1	0	536	0	2	4
B-C	-117.3893	-153.2009	-317.046	-587.6361	94	18	1	12057	12	36	16
B-E	0.0	0.0	-3.9926	-3.9926	6	0	0	128	0	3	5
B-G	0.0	0.0	-24.7562	-24.7562	39	0	0	1434	0	10	11
B-H	0.0	0.0	-3.2744	-3.2744	7	0	0	146	0	3	4
B-J	-11.9682	9.3867	-24.4715	-27.053	35	1	0	1282	2	23	23
B-K	0.0	0.0	-0.0154	-0.0154	2	0	0	10	0	0	0
C-G	-12.5395	0.0	-29.1366	-41.6761	25	3	0	1476	0	3	1
D-E	-218.4665	-92.0854	-1087.02	-1397.5719	257	42	26	43177	6	72	61
D-F	-22.4958	-57.4672	-142.734	-222.6971	55	18	4	5553	5	15	11
D-P	-16.3153	-13.7121	-80.8275	-110.8549	34	3	0	2838	0	14	15
D-Q	-7.1518	27.4344	-15.0354	5.2472	11	3	0	590	0	2	4
E-F	-113.3108	-151.293	-328.473	-593.0768	96	15	1	12112	12	38	16
E-P	-8.5353	4.9763	-22.3466	-25.9056	34	0	0	1183	1	23	23
E-Q	0.0	0.0	-0.016	-0.016	2	0	0	10	0	0	0
G-H	-217.5344	-92.2479	-1081.16	-1390.9423	255	51	25	43219	6	73	61
G-I	-21.0191	-56.12	-138.13	-215.2691	54	20	3	5504	5	15	9
G-M	-16.2575	-12.7901	-82.5287	-111.5763	37	3	0	2865	0	14	16
G-N	0.0	30.6391	-14.182	16.4571	11	3	0	615	0	2	4
H-I	-93.9614	-150.7901	-318.364	-563.1155	95	12	1	11906	12	37	16
H-M	-10.8451	11.84	-23.4299	-22.435	35	0	0	1194	1	23	23
H-N	0.0	0.0	-0.012	-0.012	2	0	0	8	0	0	1
J-K	-245.4948	-91.4671	-1090.52	-1427.4819	258	47	26	43225	6	72	61
J-L	-22.8595	-57.7768	-140.111	-220.7473	55	18	4	5506	5	15	11
J-N	0.0	0.0	-20.7958	-20.7958	22	5	0	1258	0	7	6
J-O	0.0	0.0	-3.0701	-3.0701	17	0	0	464	0	1	0
J-V	0.0	8.3697	-0.4885	7.8812	18	0	0	126	0	9	12
K-L	-102.8886	-152.2133	-322.131	-577.2329	94	15	1	12106	12	37	16
K-N	0.0	0.0	-2.9109	-2.9109	5	1	0	108	0	3	5
K-P	-8.4253	0.0	-30.0922	-38.5175	30	4	0	1389	0	9	6
K-Q	0.0	0.0	-3.9422	-3.9422	6	0	0	130	0	3	5
L-P	0.0	0.0	-10.5791	-10.5791	22	0	0	938	0	1	1
M-N	-248.7195	-92.2267	-1098.17	-1439.1161	257	54	25	43372	7	74	61
M-O	-21.0103	-55.4591	-141.282	-217.7514	54	17	4	5487	5	15	9
N-O	-80.795	-151.1346	-312.173	-544.1026	94	12	1	11881	12	38	16
P-Q	-254.7623	-93.4991	-1086.74	-1435.0014	258	52	26	43302	7	74	64
P-R	-22.7331	-57.0607	-139.196	-218.9898	55	19	4	5474	5	15	11
P-S	0.0	6.4536	-2.047	4.4066	20	0	0	304	0	9	14
P-V	0.0	8.6936	-0.5079	8.1857	15	0	0	124	0	8	12
Q-R	-108.8707	-153.2924	-321.592	-583.7551	93	15	1	12122	12	36	16
S-T	-250.089	-91.4385	-1088.49	-1430.0174	257	46	26	43290	6	73	60
S-U	-23.479	-57.3548	-142.444	-223.2778	55	18	4	5481	5	15	11
S-W	0.0	0.0	-20.1393	-20.1393	22	6	0	1271	0	7	6
S-X	0.0	0.0	-3.0007	-3.0007	17	0	0	459	0	1	0
S-1	-30.2751	-14.439	-82.5599	-127.2739	38	5	0	2853	0	15	15
S-2	-12.4563	9.2112	-23.566	-26.811	35	1	0	1273	2	23	23
T-U	-97.5222	-151.5804	-322.222	-571.3246	93	14	1	12079	12	35	16
T-W	0.0	0.0	-2.9069	-2.9069	5	1	0	108	0	3	5
T-Y	-9.7453	0.0	-20.1755	-29.9208	27	2	0	975	0	9	5
T-Z	0.0	0.0	-3.9616	-3.9616	6	0	0	130	0	3	5
T-1	-7.4052	25.4971	-13.8919	4.2	10	1	0	540	0	2	4
T-2	0.0	0.0	-0.0086	-0.0086	2	0	0	7	0	0	0
U-Y	0.0	0.0	-10.6132	-10.6132	22	0	0	937	0	1	1
V-W	-244.1754	-93.9239	-1094.8	-1432.8993	259	47	25	43298	6	74	61
V-X	-21.5593	-56.4886	-142.873	-220.9209	54	17	4	5521	5	15	10
V-7	-15.5084	-13.0165	-83.5679	-112.0928	38	3	0	2877	0	15	16
V-8	-11.1578	11.89	-0.0987	0.6335	10	0	0	20	0	0	0
W-X	-80.86	-149.3131	-311.889	-542.062	94	9	1	11882	12	36	16
W-7	-7.1458	29.4824	-15.2031	7.1335	11	4	0	644	0	2	4
Y-Z	-250.4426	-97.239	-1095.9	-1443.5816	257	41	26	43085	6	74	62
Y-0	-25.0426	-57.6742	-132.516	-215.2328	55	21	4	5434	5	15	10
Y-4	-18.6061	-13.8188	-82.0295	-114.4545	34	3	0	2846	0	14	15
Y-5	-8.629	4.6893	-22.7504	-26.6901	34	1	0	1198	1	23	23
Z-0	-102.1267	-152.7135	-320.315	-575.1552	93	15	1	12108	12	36	16
Z-4	0.0	14.8855	-8.5463	6.3392	11	1	0	523	0	2	4
1-2	-228.5551	-93.231	-1010.17	-1331.9561	256	56	26	43374	6	75	64
1-3	-22.7436	-56.592	-133.038	-212.3736	55	21	4	5469	5	15	10
1-5	-10.0846	0.0	-18.5964	-28.681	24	2	0	949	0	9	5
1-6	0.0	0.0	-9.9932	-9.9932	22	0	0	903	0	1	1
2-3	-112.5245	-153.0624	-316.417	-582.0038	94	17	1	12048	12	36	16
2-5	0.0	0.0	-3.9047	-3.9047	6	0	0	127	0	3	5
2-7	0.0	0.0	-29.2965	-29.2965	40	1	0	1504	0	10	11
3-7	-12.6203	0.0	-28.6265	-41.2468	25	2	0	1464	0	3	1
4-5	-220.9118	-92.5776	-1097.54	-1411.0294	256	44	26	43135	6	73	60
4-6	-21.8465	-57.1056	-143.629	-222.5811	55	19	4	5550	5	15	11
5-6	-106.392	-150.7862	-322.238	-579.4163	94	15	1	12068	12	35	16
7-8	-223.1963	-92.1106	-534.537	-849.8439	171	11	12	21105	5	42	36
7-9	-20.4637	-55.5713			14
8-9	-95.1245	-151.6019			23

Interface residues

• A-B: ALA100B, ALA103B, ALA137B, ALA17A, ALA18A, ALA211B, ALA235A, ALA242A, ALA24A, ALA257A, ALA9B, ARG108B, ARG14B, ARG15A, ARG15B, ARG172A, ARG174A, ARG195B, ARG215B, ARG225B, ARG244B, ARG259A, ARG260A, ARG37A, ASN102B, ASN138A, ASN167A, ASN170A, ASN180B, ASN188B, ASN203A, ASN212B, ASN222B, ASN229B, ASN241B, ASN246A, ASN24B, ASN272A, ASN30A, ASN34A, ASN41A, ASN42A, ASP105B, ASP109B, ASP10A, ASP11B, ASP134A, ASP139B, ASP149B, ASP201A, ASP205B, ASP211A, ASP219B, ASP238B, ASP252A, ASP270A, ASP27B, ASP30B, ASP35A, ASP3B, ASP7B, CYS147B, CYS8B, GLN106B, GLN162A, GLN164A, GLN178B, GLN195A, GLN196B, GLN19B, GLN205A, GLN20B, GLN240A, GLN248A, GLN261A, GLN4B, GLN5B, GLU113B, GLU12A, GLU159A, GLU200A, GLU218B, GLU221B, GLU230B, GLU236A, GLU238A, GLU245A, GLU28A, GLU31A, GLU99B, GLY114B, GLY115B, GLY138B, GLY139A, GLY140B, GLY146B, GLY171A, GLY183B, GLY185B, GLY190B, GLY191B, GLY202A, GLY214B, GLY234B, GLY242B, GLY27A, HIS135A, HIS152B, HIS161A, HIS197A, HIS209A, HIS209B, HIS23A, ILE132B, ILE134B, ILE144B, ILE16A, ILE194A, ILE210B, ILE212A, ILE213B, ILE21A, ILE21B, ILE224B, ILE231B, ILE239B, ILE243A, ILE269A, ILE274A, ILE29B, LEU10B, LEU110B, LEU12B, LEU16B, LEU175B, LEU177B, LEU189B, LEU192A, LEU193B, LEU206A, LEU216B, LEU228B, LEU243B, LEU258A, LEU25B, LEU262A, LEU275A, LEU28B, LEU31B, LEU35B, LEU38A, LEU39A, LEU39B, LEU40A, LEU45A, LEU46A, LEU6B, LEU96B, LYS133A, LYS135B, LYS136B, LYS13A, LYS142B, LYS143B, LYS145B, LYS181B, LYS193A, LYS19A, LYS210A, LYS223B, LYS235B, LYS237B, LYS23B, LYS256A, LYS268A, LYS273A, MET13B, MET174B, MET187B, MET197B, MET220B, MET250A, PHE104B, PHE112B, PHE163A, PHE168A, PHE20A, PHE233B, PHE255A, PHE29A, PHE33A, PRO137A, PRO165A, PRO17B, PRO18B, PRO208B, PRO25A, PRO263A, PRO26A, PRO33B, SER141B, SER150B, SER160A, SER184B, SER192B, SER206B, SER207B, SER208A, SER226B, SER244A, SER251A, SER26B, SER276A, SER34B, SER9A, THR172B, THR179B, THR182B, THR186B, THR194B, THR227B, THR22A, THR236B, THR241A, THR249A, THR253A, THR254A, THR265A, THR267A, TRP148B, TRP169A, TRP173A, TRP176B, TRP271A, TYR107B, TYR111B, TYR131A, TYR136A, TYR198A, TYR199A, TYR232B, TYR239A, TYR247A, VAL132A, VAL14A, VAL173B, VAL196A, VAL204A, VAL207A, VAL217B, VAL240B, VAL264A, VAL32A, VAL32B, VAL36A, VAL8A
• A-C: ALA481C, ALA50A, ALA51A, ARG102A, ARG37A, ARG47A, ASN203A, ASN30A, ASN34A, ASN42A, ASN44A, ASN476C, ASN485C, ASP201A, ASP35A, ASP43A, ASP478C, ASP479C, ASP99A, GLU104A, GLU200A, GLU28A, GLU31A, GLU484C, GLU48A, GLY202A, GLY49A, HIS100A, HIS197A, HIS488C, ILE21A, ILE480C, LEU101A, LEU38A, LEU40A, LEU45A, LEU46A, LEU486C, LEU487C, LEU489C, LYS103A, LYS166A, PHE168A, PHE29A, PHE33A, PHE477C, PHE54A, PRO165A, SER482C, SER483C, THR490C, TYR199A, VAL32A, VAL36A, VAL475C
• A-E: ALA186A, ALA9E, ASP11E, ASP125E, ASP211A, ASP3E, ASP7E, CYS8E, GLN151A, GLN187A, GLN196E, GLN213A, GLN217A, GLN4E, GLN5E, HIS126E, ILE181A, ILE212A, LEU10E, LEU6E, LYS168E, LYS210A, PRO183A, PRO184A, SER215A, SER219A, THR180A, THR182A, THR185A, VAL218A
• A-F: ALA186A, ALA491F, ASN485F, ASN492F, ASP214A, GLN187A, GLN217A, GLU484F, HIS488F, LEU486F, LEU487F, LEU489F, LYS495F, PRO183A, PRO184A, SER215A, SER219A, SER220A, THR185A, THR490F, VAL216A, VAL218A
• A-J: ALA130J, ARG259A, ARG260A, ARG266A, ASN138J, ASN234J, ASN237J, ASP134J, ASP252A, ASP71J, GLN162J, GLN164J, GLN240J, GLN248A, GLN261A, GLU233J, GLU236J, GLU238J, GLY139J, HIS135J, ILE229J, LEU262A, LYS133J, LYS226J, LYS230J, LYS256A, LYS268A, PRO137J, PRO263A, SER251A, THR241J, THR265A, THR267A, TRP173J, TYR131J, TYR136J, TYR198A, VAL132J, VAL264A
• A-K: ARG244K, ARG260A, ARG266A, ASN241K, GLN261A, GLY242K, LEU243K, LEU262A, LYS256A, PRO263A
• B-C: ALA129B, ALA491C, ALA87B, ALA9B, ARG14B, ARG15B, ARG195B, ARG493C, ARG499C, ARG500C, ARG66B, ARG72B, ASN485C, ASN492C, ASN65B, ASP11B, ASP123B, ASP38B, ASP44B, ASP63B, ASP67B, ASP69B, ASP7B, ASP85B, CYS36B, CYS62B, CYS8B, GLN196B, GLN45B, GLN4B, GLN5B, GLU155B, GLU37B, GLU484C, GLU84B, GLY130B, GLY498C, GLY503C, GLY68B, GLY86B, HIS152B, HIS488C, ILE151B, ILE29B, LEU10B, LEU121B, LEU124B, LEU12B, LEU133B, LEU169B, LEU193B, LEU35B, LEU39B, LEU40B, LEU486C, LEU487C, LEU489C, LEU501C, LEU6B, LEU83B, LYS168B, LYS495C, MET13B, MET174B, MET197B, MET220B, MET496C, PHE128B, PRO33B, PRO494C, PRO497C, PRO502C, SER171B, SER192B, SER34B, SER41B, SER42B, SER482C, SER483C, SER70B, THR170B, THR172B, THR194B, THR490C, TRP122B, TYR120B, TYR64B, TYR71B, TYR79B, VAL131B, VAL153B, VAL154B, VAL156B, VAL43B
• B-E: ASP125E, GLU158E, GLY183B, HIS126E, LYS181B, THR182B
• B-G: ALA9B, ASP11B, ASP125B, ASP211G, ASP214G, ASP38B, ASP3B, ASP7B, CYS8B, GLN151G, GLN152G, GLN157B, GLN187G, GLN196B, GLN213G, GLN217G, GLN4B, GLN5B, GLU155B, GLU238G, GLY150G, HIS126B, ILE181G, ILE212G, ILE231G, LEU10B, LEU6B, LYS168B, LYS210G, PRO183G, PRO184G, SER215G, SER219G, SER42B, THR170B, THR182G, THR185G, VAL216G, VAL218G
• B-H: ASP125B, GLU158B, GLY183H, GLY185H, HIS126B, LYS181H, THR182H
• B-J: ALA130J, ARG129J, ARG225B, ASN138J, ASN222B, ASN229B, ASP134J, ASP219B, ASP238B, ASP71J, ASP72J, GLU201B, GLU218B, GLU221B, GLU230B, GLY234B, GLY69J, HIS135J, ILE231B, LYS133J, LYS199B, LYS223B, LYS226J, LYS235B, LYS66J, PHE140J, PRO137J, SER126J, SER226B, THR227B, TYR111B, TYR131J, TYR136J, VAL132J, VAL222J
• B-K: ARG225B, ARG244K
• C-G: ALA186G, ALA491C, ARG493C, ASN485C, ASN492C, ASP214G, GLN187G, GLN217G, GLN223G, GLU484C, HIS488C, LEU486C, LEU487C, LEU489C, LYS495C, PRO183G, PRO184G, SER215G, SER219G, SER220G, THR182G, THR185G, THR490C, VAL216G, VAL218G
• D-E: ALA100E, ALA103E, ALA137E, ALA17D, ALA18D, ALA211E, ALA235D, ALA242D, ALA24D, ALA257D, ALA9E, ARG108E, ARG14E, ARG15D, ARG15E, ARG172D, ARG174D, ARG195E, ARG215E, ARG225E, ARG244E, ARG259D, ARG260D, ARG37D, ASN102E, ASN138D, ASN167D, ASN170D, ASN180E, ASN188E, ASN203D, ASN212E, ASN222E, ASN229E, ASN237D, ASN241E, ASN246D, ASN24E, ASN272D, ASN30D, ASN34D, ASN41D, ASN42D, ASP105E, ASP109E, ASP10D, ASP11E, ASP134D, ASP139E, ASP149E, ASP201D, ASP205E, ASP211D, ASP219E, ASP238E, ASP252D, ASP270D, ASP27E, ASP30E, ASP35D, ASP3E, ASP7E, CYS147E, CYS8E, GLN106E, GLN162D, GLN164D, GLN178E, GLN195D, GLN196E, GLN19E, GLN205D, GLN20E, GLN240D, GLN248D, GLN261D, GLN4E, GLN5E, GLU113E, GLU12D, GLU159D, GLU200D, GLU218E, GLU221E, GLU230E, GLU236D, GLU238D, GLU245D, GLU28D, GLU31D, GLU99E, GLY114E, GLY115E, GLY138E, GLY139D, GLY140E, GLY146E, GLY171D, GLY183E, GLY185E, GLY190E, GLY191E, GLY202D, GLY214E, GLY234E, GLY242E, GLY27D, HIS135D, HIS152E, HIS161D, HIS197D, HIS209D, HIS209E, HIS23D, ILE132E, ILE134E, ILE144E, ILE16D, ILE194D, ILE210E, ILE212D, ILE213E, ILE21D, ILE21E, ILE224E, ILE231E, ILE239E, ILE243D, ILE269D, ILE274D, ILE29E, LEU10E, LEU110E, LEU12E, LEU16E, LEU175E, LEU177E, LEU189E, LEU192D, LEU193E, LEU206D, LEU216E, LEU228E, LEU243E, LEU258D, LEU25E, LEU262D, LEU275D, LEU28E, LEU31E, LEU35E, LEU38D, LEU39D, LEU39E, LEU40D, LEU45D, LEU46D, LEU6E, LEU96E, LYS133D, LYS135E, LYS136E, LYS13D, LYS142E, LYS143E, LYS145E, LYS181E, LYS193D, LYS19D, LYS210D, LYS223E, LYS235E, LYS237E, LYS23E, LYS256D, LYS268D, LYS273D, MET13E, MET174E, MET187E, MET197E, MET220E, MET250D, PHE104E, PHE112E, PHE163D, PHE168D, PHE20D, PHE233E, PHE255D, PHE29D, PHE33D, PRO137D, PRO165D, PRO17E, PRO18E, PRO208E, PRO25D, PRO263D, PRO26D, PRO33E, SER141E, SER150E, SER160D, SER184E, SER192E, SER206E, SER207E, SER208D, SER226E, SER244D, SER251D, SER26E, SER276D, SER34E, SER9D, THR172E, THR179E, THR182E, THR186E, THR194E, THR227E, THR22D, THR236E, THR241D, THR249D, THR253D, THR254D, THR265D, THR267D, TRP148E, TRP169D, TRP173D, TRP176E, TRP271D, TYR107E, TYR111E, TYR131D, TYR136D, TYR198D, TYR199D, TYR232E, TYR239D, TYR247D, VAL132D, VAL14D, VAL173E, VAL196D, VAL204D, VAL207D, VAL217E, VAL240E, VAL264D, VAL32D, VAL32E, VAL36D, VAL8D
• D-F: ALA481F, ALA50D, ALA51D, ARG102D, ARG37D, ARG47D, ASN203D, ASN30D, ASN34D, ASN42D, ASN44D, ASN476F, ASN485F, ASP201D, ASP35D, ASP43D, ASP478F, ASP479F, ASP99D, GLU104D, GLU200D, GLU28D, GLU31D, GLU484F, GLU48D, GLY202D, GLY49D, HIS100D, HIS197D, HIS488F, ILE21D, ILE480F, LEU101D, LEU38D, LEU40D, LEU45D, LEU46D, LEU486F, LEU487F, LEU489F, LYS103D, LYS166D, PHE168D, PHE29D, PHE33D, PHE477F, PHE54D, PRO165D, SER482F, SER483F, THR490F, TYR199D, VAL32D, VAL36D, VAL475F
• D-P: ALA130P, ARG259D, ARG260D, ARG266D, ASN138P, ASN234P, ASN237P, ASP134P, ASP252D, GLN162P, GLN240P, GLN248D, GLN261D, GLU233P, GLU236P, GLU238P, GLY139P, HIS135P, ILE229P, LEU262D, LYS133P, LYS226P, LYS230P, LYS256D, LYS268D, PRO137P, PRO263D, THR241P, THR265D, THR267D, TYR131P, TYR136P, VAL132P, VAL264D
• D-Q: ARG244Q, ARG260D, ARG266D, ASN241Q, GLN261D, GLY242Q, LEU243Q, LEU262D, LYS256D, PRO263D, VAL264D
• E-F: ALA129E, ALA491F, ALA87E, ALA9E, ARG14E, ARG15E, ARG195E, ARG493F, ARG499F, ARG500F, ARG66E, ARG72E, ASN485F, ASN492F, ASN65E, ASP11E, ASP123E, ASP38E, ASP3E, ASP44E, ASP63E, ASP67E, ASP69E, ASP7E, ASP85E, CYS36E, CYS62E, CYS8E, GLN196E, GLN45E, GLN4E, GLN5E, GLU155E, GLU37E, GLU484F, GLU84E, GLY130E, GLY498F, GLY503F, GLY68E, GLY86E, HIS152E, HIS488F, ILE151E, ILE29E, LEU10E, LEU121E, LEU124E, LEU12E, LEU133E, LEU169E, LEU193E, LEU35E, LEU39E, LEU40E, LEU47E, LEU486F, LEU487F, LEU489F, LEU501F, LEU6E, LEU83E, LYS168E, LYS495F, MET13E, MET174E, MET197E, MET220E, MET496F, PHE128E, PRO33E, PRO494F, PRO497F, PRO502F, SER171E, SER192E, SER34E, SER41E, SER42E, SER482F, SER483F, SER70E, THR170E, THR172E, THR194E, THR490F, TRP122E, TYR120E, TYR64E, TYR71E, TYR79E, VAL131E, VAL153E, VAL154E, VAL156E, VAL43E
• E-P: ALA130P, ARG129P, ARG225E, ASN138P, ASN222E, ASN229E, ASP134P, ASP219E, ASP238E, ASP71P, ASP72P, GLU218E, GLU221E, GLU230E, GLY139P, GLY234E, GLY69P, HIS135P, ILE231E, LYS133P, LYS199E, LYS223E, LYS226P, LYS235E, LYS66P, PHE140P, PRO137P, SER226E, THR227E, TYR111E, TYR131P, TYR136P, VAL132P, VAL222P
• E-Q: ARG225E, ARG244Q
• G-H: ALA100H, ALA103H, ALA137H, ALA17G, ALA18G, ALA211H, ALA235G, ALA242G, ALA24G, ALA257G, ALA9H, ARG108H, ARG14H, ARG15G, ARG15H, ARG172G, ARG174G, ARG195H, ARG215H, ARG225H, ARG244H, ARG259G, ARG260G, ARG37G, ASN102H, ASN138G, ASN167G, ASN170G, ASN180H, ASN188H, ASN203G, ASN212H, ASN222H, ASN229H, ASN241H, ASN246G, ASN24H, ASN272G, ASN30G, ASN34G, ASN41G, ASN42G, ASP105H, ASP109H, ASP10G, ASP11H, ASP134G, ASP139H, ASP149H, ASP201G, ASP205H, ASP211G, ASP219H, ASP238H, ASP252G, ASP270G, ASP27H, ASP30H, ASP35G, ASP7H, CYS147H, CYS8H, GLN106H, GLN162G, GLN164G, GLN178H, GLN195G, GLN196H, GLN19H, GLN205G, GLN20H, GLN240G, GLN248G, GLN261G, GLN4H, GLN5H, GLU113H, GLU12G, GLU159G, GLU200G, GLU218H, GLU221H, GLU230H, GLU236G, GLU238G, GLU245G, GLU28G, GLU31G, GLU99H, GLY115H, GLY138H, GLY139G, GLY140H, GLY146H, GLY171G, GLY183H, GLY185H, GLY190H, GLY191H, GLY202G, GLY214H, GLY234H, GLY242H, GLY27G, HIS135G, HIS152H, HIS161G, HIS197G, HIS209G, HIS209H, HIS23G, ILE132H, ILE134H, ILE144H, ILE16G, ILE194G, ILE210H, ILE212G, ILE213H, ILE21G, ILE21H, ILE224H, ILE231H, ILE239H, ILE243G, ILE269G, ILE274G, ILE29H, LEU10H, LEU110H, LEU12H, LEU16H, LEU175H, LEU177H, LEU189H, LEU192G, LEU193H, LEU206G, LEU216H, LEU228H, LEU243H, LEU258G, LEU25H, LEU262G, LEU275G, LEU28H, LEU31H, LEU35H, LEU38G, LEU39G, LEU39H, LEU40G, LEU45G, LEU46G, LEU6H, LEU96H, LYS133G, LYS135H, LYS136H, LYS13G, LYS142H, LYS143H, LYS145H, LYS181H, LYS193G, LYS19G, LYS210G, LYS223H, LYS235H, LYS237H, LYS23H, LYS256G, LYS268G, LYS273G, MET13H, MET174H, MET187H, MET197H, MET220H, MET250G, PHE104H, PHE112H, PHE163G, PHE168G, PHE20G, PHE233H, PHE255G, PHE29G, PHE33G, PRO137G, PRO165G, PRO17H, PRO18H, PRO208H, PRO25G, PRO263G, PRO26G, PRO33H, SER141H, SER150H, SER160G, SER184H, SER192H, SER206H, SER207H, SER208G, SER226H, SER244G, SER251G, SER26H, SER276G, SER2H, SER34H, SER9G, THR172H, THR179H, THR182H, THR186H, THR194H, THR227H, THR22G, THR236H, THR241G, THR249G, THR253G, THR254G, THR265G, THR267G, TRP148H, TRP169G, TRP173G, TRP176H, TRP271G, TYR107H, TYR111H, TYR131G, TYR136G, TYR198G, TYR199G, TYR232H, TYR239G, TYR247G, VAL132G, VAL14G, VAL173H, VAL196G, VAL204G, VAL207G, VAL217H, VAL240H, VAL264G, VAL32G, VAL32H, VAL36G, VAL8G
• G-I: ALA481I, ALA50G, ALA51G, ARG102G, ARG37G, ARG47G, ASN203G, ASN30G, ASN34G, ASN42G, ASN44G, ASN476I, ASN485I, ASP201G, ASP35G, ASP43G, ASP478I, ASP479I, ASP99G, GLU200G, GLU28G, GLU31G, GLU484I, GLU48G, GLY202G, GLY49G, HIS100G, HIS197G, HIS488I, ILE21G, ILE480I, LEU101G, LEU38G, LEU40G, LEU45G, LEU46G, LEU486I, LEU487I, LEU489I, LYS103G, LYS166G, PHE168G, PHE29G, PHE33G, PHE477I, PHE54G, PRO165G, SER482I, SER483I, THR490I, TYR199G, VAL32G, VAL36G, VAL475I
• G-M: ALA130M, ARG259G, ARG260G, ARG266G, ASN138M, ASN234M, ASN237M, ASP134M, ASP252G, ASP71M, GLN162M, GLN164M, GLN240M, GLN248G, GLN261G, GLU233M, GLU236M, GLU238M, GLY139M, HIS135M, ILE229M, LEU262G, LYS133M, LYS226M, LYS230M, LYS256G, LYS268G, PRO137M, PRO263G, THR241M, THR265G, THR267G, TYR131M, TYR136M, TYR198G, VAL132M, VAL264G
• G-N: ARG244N, ARG260G, ARG266G, ASN241N, GLN261G, GLY242N, LEU243N, LEU262G, LYS256G, PRO263G, VAL264G
• H-I: ALA129H, ALA491I, ALA87H, ALA9H, ARG14H, ARG15H, ARG195H, ARG493I, ARG499I, ARG500I, ARG66H, ARG72H, ASN485I, ASN492I, ASN65H, ASP11H, ASP123H, ASP38H, ASP3H, ASP44H, ASP63H, ASP67H, ASP69H, ASP7H, ASP85H, CYS36H, CYS62H, CYS8H, GLN196H, GLN45H, GLN4H, GLN5H, GLU155H, GLU37H, GLU484I, GLU84H, GLY130H, GLY498I, GLY503I, GLY68H, GLY86H, HIS152H, HIS488I, ILE151H, ILE29H, LEU10H, LEU121H, LEU124H, LEU12H, LEU133H, LEU169H, LEU193H, LEU35H, LEU39H, LEU40H, LEU486I, LEU487I, LEU489I, LEU501I, LEU6H, LEU83H, LYS168H, LYS495I, MET13H, MET174H, MET197H, MET220H, MET496I, PHE128H, PRO33H, PRO494I, PRO497I, PRO502I, SER171H, SER192H, SER34H, SER41H, SER42H, SER482I, SER483I, SER70H, THR170H, THR172H, THR194H, THR490I, TRP122H, TYR120H, TYR64H, TYR71H, TYR79H, VAL131H, VAL153H, VAL154H, VAL156H, VAL43H
• H-M: ALA130M, ARG129M, ARG225H, ASN138M, ASN222H, ASN229H, ASP134M, ASP219H, ASP238H, ASP71M, ASP72M, GLU201H, GLU218H, GLU221H, GLU230H, GLY139M, GLY234H, GLY69M, HIS135M, ILE231H, LYS133M, LYS199H, LYS223H, LYS226M, LYS235H, LYS66M, PHE140M, PRO137M, SER226H, THR227H, TYR111H, TYR131M, TYR136M, VAL132M, VAL222M
• H-N: ARG225H, ARG244N
• J-K: ALA100K, ALA103K, ALA137K, ALA17J, ALA18J, ALA211K, ALA235J, ALA242J, ALA24J, ALA257J, ALA9K, ARG108K, ARG14K, ARG15J, ARG15K, ARG172J, ARG174J, ARG195K, ARG215K, ARG225K, ARG244K, ARG259J, ARG260J, ARG266J, ARG37J, ASN102K, ASN138J, ASN167J, ASN170J, ASN180K, ASN188K, ASN203J, ASN212K, ASN222K, ASN229K, ASN241K, ASN246J, ASN24K, ASN272J, ASN30J, ASN34J, ASN41J, ASN42J, ASP105K, ASP109K, ASP10J, ASP11K, ASP134J, ASP139K, ASP149K, ASP201J, ASP205K, ASP211J, ASP219K, ASP238K, ASP252J, ASP270J, ASP27K, ASP30K, ASP35J, ASP3K, ASP7K, CYS147K, CYS8K, GLN106K, GLN162J, GLN164J, GLN178K, GLN195J, GLN196K, GLN19K, GLN205J, GLN20K, GLN240J, GLN248J, GLN261J, GLN4K, GLN5K, GLU113K, GLU12J, GLU159J, GLU200J, GLU218K, GLU221K, GLU230K, GLU236J, GLU238J, GLU245J, GLU28J, GLU31J, GLU99K, GLY114K, GLY115K, GLY138K, GLY139J, GLY140K, GLY146K, GLY171J, GLY183K, GLY185K, GLY190K, GLY191K, GLY202J, GLY214K, GLY234K, GLY242K, GLY27J, HIS135J, HIS152K, HIS161J, HIS197J, HIS209J, HIS209K, HIS23J, ILE132K, ILE134K, ILE144K, ILE16J, ILE194J, ILE210K, ILE212J, ILE213K, ILE21J, ILE21K, ILE224K, ILE231K, ILE239K, ILE243J, ILE269J, ILE274J, ILE29K, LEU10K, LEU110K, LEU12K, LEU16K, LEU175K, LEU177K, LEU189K, LEU192J, LEU193K, LEU206J, LEU216K, LEU228K, LEU243K, LEU258J, LEU25K, LEU262J, LEU275J, LEU28K, LEU31K, LEU35K, LEU38J, LEU39J, LEU39K, LEU40J, LEU45J, LEU46J, LEU6K, LEU96K, LYS133J, LYS135K, LYS136K, LYS13J, LYS142K, LYS143K, LYS145K, LYS181K, LYS193J, LYS19J, LYS210J, LYS223K, LYS235K, LYS237K, LYS23K, LYS256J, LYS268J, LYS273J, MET13K, MET174K, MET187K, MET197K, MET220K, MET250J, PHE104K, PHE112K, PHE163J, PHE168J, PHE20J, PHE233K, PHE255J, PHE29J, PHE33J, PRO137J, PRO165J, PRO17K, PRO18K, PRO208K, PRO25J, PRO263J, PRO26J, PRO33K, SER141K, SER150K, SER160J, SER184K, SER192K, SER204K, SER206K, SER207K, SER208J, SER226K, SER244J, SER251J, SER26K, SER276J, SER34K, SER9J, THR172K, THR179K, THR182K, THR186K, THR194K, THR227K, THR22J, THR236K, THR241J, THR249J, THR253J, THR254J, THR265J, THR267J, TRP148K, TRP169J, TRP173J, TRP176K, TRP271J, TYR107K, TYR111K, TYR131J, TYR136J, TYR198J, TYR199J, TYR232K, TYR239J, TYR247J, VAL132J, VAL14J, VAL173K, VAL196J, VAL204J, VAL207J, VAL217K, VAL240K, VAL264J, VAL32J, VAL32K, VAL36J, VAL8J
• J-L: ALA481L, ALA50J, ALA51J, ARG102J, ARG37J, ARG47J, ASN203J, ASN30J, ASN34J, ASN42J, ASN44J, ASN476L, ASN485L, ASP201J, ASP35J, ASP43J, ASP478L, ASP479L, ASP99J, GLU104J, GLU200J, GLU28J, GLU31J, GLU484L, GLU48J, GLY202J, GLY49J, HIS100J, HIS197J, HIS488L, ILE21J, ILE480L, LEU101J, LEU38J, LEU40J, LEU45J, LEU46J, LEU486L, LEU487L, LEU489L, LYS103J, LYS166J, PHE168J, PHE29J, PHE33J, PHE477L, PHE54J, PRO165J, SER482L, SER483L, THR490L, TYR199J, VAL32J, VAL36J, VAL475L
• J-N: ALA186J, ASP11N, ASP125N, ASP3N, ASP7N, CYS8N, GLN151J, GLN187J, GLN213J, GLN217J, GLN4N, GLN5N, ILE181J, LEU10N, LEU6N, PRO183J, PRO184J, SER215J, SER2N, THR182J, THR185J, VAL218J
• J-O: ALA491O, ASN485O, ASN492O, GLN217J, GLU484O, HIS488O, LEU486O, LEU487O, LEU489O, LYS495O, PRO183J, PRO184J, SER215J, SER219J, SER220J, THR185J, VAL216J
• J-V: ASN42J, ASN44J, ASN84V, ASP10J, ASP112V, ASP149V, GLU111V, GLU114V, GLU11J, GLU48J, GLY150V, GLY83V, ILE148V, LEU82V, LYS13J, SER115V, SER147V, SER9J
• K-L: ALA129K, ALA491L, ALA87K, ALA9K, ARG14K, ARG15K, ARG195K, ARG493L, ARG499L, ARG500L, ARG66K, ARG72K, ASN485L, ASN492L, ASN65K, ASP11K, ASP123K, ASP38K, ASP3K, ASP44K, ASP63K, ASP67K, ASP69K, ASP7K, ASP85K, CYS36K, CYS62K, CYS8K, GLN196K, GLN45K, GLN4K, GLN5K, GLU155K, GLU37K, GLU484L, GLU84K, GLY130K, GLY498L, GLY503L, GLY68K, GLY86K, HIS152K, HIS488L, ILE151K, ILE29K, LEU10K, LEU121K, LEU124K, LEU12K, LEU133K, LEU169K, LEU193K, LEU35K, LEU39K, LEU40K, LEU486L, LEU487L, LEU489L, LEU501L, LEU6K, LEU83K, LYS168K, LYS495L, MET13K, MET174K, MET197K, MET220K, MET496L, PHE128K, PRO33K, PRO494L, PRO497L, PRO502L, SER171K, SER34K, SER41K, SER42K, SER482L, SER483L, SER70K, THR170K, THR172K, THR194K, THR490L, TRP122K, TYR120K, TYR64K, TYR71K, TYR79K, VAL131K, VAL153K, VAL154K, VAL156K, VAL43K
• K-N: ASP125N, GLU158N, HIS126N, LYS181K, THR182K
• K-P: ALA186P, ALA9K, ASP11K, ASP125K, ASP211P, ASP3K, ASP7K, CYS8K, GLN151P, GLN187P, GLN196K, GLN213P, GLN217P, GLN4K, GLN5K, HIS126K, ILE181P, ILE212P, LEU10K, LEU6K, LYS168K, LYS210P, PRO183P, PRO184P, SER215P, SER219P, THR180P, THR182P, THR185P, VAL218P
• K-Q: ASP125K, GLU158K, GLY183Q, HIS126K, LYS181Q, THR182Q
• L-P: ALA186P, ALA491L, ASN485L, ASN492L, ASP214P, GLN187P, GLN217P, GLU484L, HIS488L, LEU486L, LEU487L, LEU489L, LYS495L, PRO183P, PRO184P, SER215P, SER219P, SER220P, THR185P, THR490L, VAL216P, VAL218P
• M-N: ALA100N, ALA103N, ALA137N, ALA17M, ALA18M, ALA211N, ALA235M, ALA242M, ALA24M, ALA257M, ALA9N, ARG108N, ARG14N, ARG15M, ARG15N, ARG172M, ARG174M, ARG195N, ARG215N, ARG225N, ARG244N, ARG259M, ARG260M, ARG37M, ASN102N, ASN138M, ASN167M, ASN170M, ASN180N, ASN188N, ASN203M, ASN212N, ASN222N, ASN229N, ASN241N, ASN246M, ASN24N, ASN272M, ASN30M, ASN34M, ASN41M, ASN42M, ASP105N, ASP109N, ASP10M, ASP11N, ASP134M, ASP139N, ASP149N, ASP201M, ASP205N, ASP211M, ASP219N, ASP238N, ASP252M, ASP270M, ASP27N, ASP30N, ASP35M, ASP7N, CYS147N, CYS8N, GLN106N, GLN162M, GLN164M, GLN178N, GLN195M, GLN196N, GLN19N, GLN205M, GLN20N, GLN240M, GLN248M, GLN261M, GLN4N, GLN5N, GLU113N, GLU12M, GLU159M, GLU200M, GLU218N, GLU221N, GLU230N, GLU236M, GLU238M, GLU245M, GLU28M, GLU31M, GLU99N, GLY114N, GLY115N, GLY138N, GLY139M, GLY140N, GLY146N, GLY171M, GLY183N, GLY185N, GLY190N, GLY191N, GLY202M, GLY214N, GLY234N, GLY242N, GLY27M, HIS135M, HIS152N, HIS161M, HIS197M, HIS209M, HIS209N, HIS23M, ILE132N, ILE134N, ILE144N, ILE16M, ILE194M, ILE210N, ILE212M, ILE213N, ILE21M, ILE21N, ILE224N, ILE231N, ILE239N, ILE243M, ILE269M, ILE274M, ILE29N, LEU10N, LEU110N, LEU12N, LEU16N, LEU175N, LEU177N, LEU189N, LEU192M, LEU193N, LEU206M, LEU216N, LEU228N, LEU243N, LEU258M, LEU25N, LEU262M, LEU275M, LEU28N, LEU31N, LEU35N, LEU38M, LEU39M, LEU39N, LEU40M, LEU45M, LEU46M, LEU6N, LEU96N, LYS133M, LYS135N, LYS136N, LYS13M, LYS142N, LYS143N, LYS145N, LYS181N, LYS193M, LYS19M, LYS210M, LYS223N, LYS235N, LYS237N, LYS23N, LYS256M, LYS268M, LYS273M, MET13N, MET174N, MET187N, MET197N, MET220N, MET250M, PHE104N, PHE112N, PHE163M, PHE168M, PHE20M, PHE233N, PHE255M, PHE29M, PHE33M, PRO137M, PRO165M, PRO17N, PRO18N, PRO208N, PRO25M, PRO263M, PRO26M, PRO33N, SER141N, SER150N, SER160M, SER184N, SER192N, SER204N, SER206N, SER207N, SER208M, SER226N, SER244M, SER251M, SER26N, SER276M, SER2N, SER34N, SER9M, THR172N, THR179N, THR182N, THR186N, THR194N, THR227N, THR22M, THR236N, THR241M, THR249M, THR253M, THR254M, THR265M, THR267M, TRP148N, TRP169M, TRP173M, TRP176N, TRP271M, TYR107N, TYR111N, TYR131M, TYR136M, TYR198M, TYR199M, TYR232N, TYR239M, TYR247M, VAL132M, VAL14M, VAL173N, VAL196M, VAL204M, VAL207M, VAL217N, VAL240N, VAL264M, VAL32M, VAL32N, VAL36M, VAL8M
• M-O: ALA481O, ALA50M, ALA51M, ARG102M, ARG37M, ARG47M, ASN203M, ASN30M, ASN34M, ASN42M, ASN44M, ASN476O, ASN485O, ASP201M, ASP35M, ASP43M, ASP478O, ASP479O, ASP99M, GLU200M, GLU28M, GLU31M, GLU484O, GLU48M, GLY202M, GLY49M, HIS100M, HIS197M, HIS488O, ILE21M, ILE480O, LEU101M, LEU38M, LEU40M, LEU45M, LEU46M, LEU486O, LEU487O, LEU489O, LYS103M, LYS166M, PHE168M, PHE29M, PHE33M, PHE477O, PHE54M, PRO165M, SER482O, SER483O, THR490O, TYR199M, VAL32M, VAL36M, VAL475O
• N-O: ALA129N, ALA491O, ALA87N, ALA9N, ARG14N, ARG15N, ARG195N, ARG493O, ARG499O, ARG500O, ARG66N, ARG72N, ASN485O, ASN492O, ASN65N, ASP11N, ASP123N, ASP38N, ASP3N, ASP44N, ASP63N, ASP67N, ASP69N, ASP7N, ASP85N, CYS36N, CYS62N, CYS8N, GLN196N, GLN45N, GLN4N, GLN5N, GLU155N, GLU37N, GLU484O, GLU84N, GLY130N, GLY498O, GLY503O, GLY68N, GLY86N, HIS152N, HIS488O, ILE151N, ILE29N, LEU10N, LEU121N, LEU124N, LEU12N, LEU133N, LEU169N, LEU193N, LEU35N, LEU39N, LEU40N, LEU486O, LEU487O, LEU489O, LEU501O, LEU6N, LEU83N, LYS168N, LYS495O, MET13N, MET174N, MET197N, MET220N, MET496O, PHE128N, PRO33N, PRO494O, PRO497O, PRO502O, SER171N, SER34N, SER41N, SER42N, SER482O, SER483O, SER70N, THR170N, THR172N, THR194N, THR490O, TRP122N, TYR120N, TYR64N, TYR71N, TYR79N, VAL131N, VAL153N, VAL154N, VAL156N, VAL43N
• P-Q: ALA100Q, ALA103Q, ALA137Q, ALA17P, ALA18P, ALA211Q, ALA235P, ALA242P, ALA24P, ALA257P, ALA9Q, ARG108Q, ARG14Q, ARG15P, ARG15Q, ARG172P, ARG174P, ARG195Q, ARG215Q, ARG225Q, ARG244Q, ARG259P, ARG260P, ARG266P, ARG37P, ASN102Q, ASN138P, ASN167P, ASN170P, ASN180Q, ASN188Q, ASN203P, ASN212Q, ASN222Q, ASN229Q, ASN241Q, ASN246P, ASN24Q, ASN272P, ASN30P, ASN34P, ASN41P, ASN42P, ASP105Q, ASP109Q, ASP10P, ASP11Q, ASP134P, ASP139Q, ASP149Q, ASP201P, ASP205Q, ASP211P, ASP219Q, ASP238Q, ASP252P, ASP270P, ASP27Q, ASP30Q, ASP35P, ASP3Q, ASP7Q, CYS147Q, CYS8Q, GLN106Q, GLN162P, GLN164P, GLN178Q, GLN195P, GLN196Q, GLN19Q, GLN205P, GLN20Q, GLN240P, GLN248P, GLN261P, GLN4Q, GLN5Q, GLU113Q, GLU12P, GLU159P, GLU200P, GLU218Q, GLU221Q, GLU230Q, GLU236P, GLU238P, GLU245P, GLU28P, GLU31P, GLU99Q, GLY114Q, GLY115Q, GLY138Q, GLY139P, GLY140Q, GLY146Q, GLY171P, GLY183Q, GLY185Q, GLY190Q, GLY191Q, GLY202P, GLY214Q, GLY234Q, GLY242Q, GLY27P, HIS135P, HIS152Q, HIS161P, HIS197P, HIS209P, HIS209Q, HIS23P, ILE132Q, ILE134Q, ILE144Q, ILE16P, ILE194P, ILE210Q, ILE212P, ILE213Q, ILE21P, ILE21Q, ILE224Q, ILE231Q, ILE239Q, ILE243P, ILE269P, ILE274P, ILE29Q, LEU10Q, LEU110Q, LEU12Q, LEU16Q, LEU175Q, LEU177Q, LEU189Q, LEU192P, LEU193Q, LEU206P, LEU216Q, LEU228Q, LEU243Q, LEU258P, LEU25Q, LEU262P, LEU275P, LEU28Q, LEU31Q, LEU35Q, LEU38P, LEU39P, LEU39Q, LEU40P, LEU45P, LEU46P, LEU6Q, LEU96Q, LYS133P, LYS135Q, LYS136Q, LYS13P, LYS142Q, LYS143Q, LYS145Q, LYS181Q, LYS193P, LYS19P, LYS210P, LYS223Q, LYS235Q, LYS237Q, LYS23Q, LYS256P, LYS268P, LYS273P, MET13Q, MET174Q, MET187Q, MET197Q, MET220Q, MET250P, PHE104Q, PHE112Q, PHE163P, PHE168P, PHE20P, PHE233Q, PHE255P, PHE29P, PHE33P, PRO137P, PRO165P, PRO17Q, PRO18Q, PRO208Q, PRO25P, PRO263P, PRO26P, PRO33Q, SER141Q, SER150Q, SER160P, SER184Q, SER192Q, SER204Q, SER206Q, SER207Q, SER208P, SER226Q, SER244P, SER251P, SER26Q, SER276P, SER34Q, SER9P, THR172Q, THR179Q, THR182Q, THR186Q, THR194Q, THR227Q, THR22P, THR236Q, THR241P, THR249P, THR253P, THR254P, THR265P, THR267P, TRP148Q, TRP169P, TRP173P, TRP176Q, TRP271P, TYR107Q, TYR111Q, TYR131P, TYR136P, TYR198P, TYR199P, TYR232Q, TYR239P, TYR247P, VAL132P, VAL14P, VAL173Q, VAL196P, VAL204P, VAL207P, VAL217Q, VAL240Q, VAL264P, VAL32P, VAL32Q, VAL36P, VAL8P
• P-R: ALA481R, ALA50P, ALA51P, ARG102P, ARG37P, ARG47P, ASN203P, ASN30P, ASN34P, ASN42P, ASN44P, ASN476R, ASN485R, ASP201P, ASP35P, ASP43P, ASP478R, ASP479R, ASP99P, GLU104P, GLU200P, GLU28P, GLU31P, GLU484R, GLU48P, GLY202P, GLY49P, HIS100P, HIS197P, HIS488R, ILE21P, ILE480R, LEU101P, LEU38P, LEU40P, LEU45P, LEU46P, LEU486R, LEU487R, LEU489R, LYS103P, LYS166P, PHE168P, PHE29P, PHE33P, PHE477R, PHE54P, PRO165P, SER482R, SER483R, THR490R, TYR199P, VAL32P, VAL36P, VAL475R
• P-S: ALA116S, ARG47P, ASN44P, ASN84S, ASP10P, ASP112S, ASP149S, ASP81S, GLN151S, GLU111S, GLU114S, GLU11P, GLU48P, GLY150S, ILE148S, LEU82S, LYS13P, SER115S, SER147S, SER9P
• P-V: ARG47V, ASN44V, ASP10V, ASP112P, ASP149P, GLU111P, GLU114P, GLU11V, GLU48V, GLY150P, ILE148P, LEU82P, SER115P, SER147P, SER9V
• Q-R: ALA129Q, ALA491R, ALA87Q, ALA9Q, ARG14Q, ARG15Q, ARG195Q, ARG493R, ARG499R, ARG500R, ARG66Q, ARG72Q, ASN485R, ASN492R, ASN65Q, ASP11Q, ASP123Q, ASP38Q, ASP44Q, ASP63Q, ASP67Q, ASP69Q, ASP7Q, ASP85Q, CYS36Q, CYS62Q, CYS8Q, GLN196Q, GLN45Q, GLN4Q, GLN5Q, GLU155Q, GLU37Q, GLU484R, GLU84Q, GLY130Q, GLY498R, GLY503R, GLY68Q, GLY86Q, HIS152Q, HIS488R, ILE151Q, ILE29Q, LEU10Q, LEU121Q, LEU124Q, LEU12Q, LEU133Q, LEU169Q, LEU193Q, LEU35Q, LEU39Q, LEU40Q, LEU486R, LEU487R, LEU489R, LEU501R, LEU6Q, LEU83Q, LYS168Q, LYS495R, MET13Q, MET174Q, MET197Q, MET220Q, MET496R, PHE128Q, PRO33Q, PRO494R, PRO497R, PRO502R, SER171Q, SER34Q, SER41Q, SER42Q, SER482R, SER483R, SER70Q, THR170Q, THR172Q, THR194Q, THR490R, TRP122Q, TYR120Q, TYR64Q, TYR71Q, TYR79Q, VAL131Q, VAL153Q, VAL154Q, VAL156Q, VAL43Q
• S-T: ALA100T, ALA103T, ALA137T, ALA17S, ALA18S, ALA211T, ALA235S, ALA242S, ALA24S, ALA257S, ALA9T, ARG108T, ARG14T, ARG15S, ARG15T, ARG172S, ARG174S, ARG195T, ARG215T, ARG225T, ARG244T, ARG259S, ARG260S, ARG266S, ARG37S, ASN102T, ASN138S, ASN167S, ASN170S, ASN180T, ASN188T, ASN203S, ASN212T, ASN222T, ASN229T, ASN241T, ASN246S, ASN24T, ASN272S, ASN30S, ASN34S, ASN41S, ASN42S, ASP105T, ASP109T, ASP10S, ASP11T, ASP134S, ASP139T, ASP149T, ASP201S, ASP205T, ASP211S, ASP219T, ASP238T, ASP252S, ASP270S, ASP27T, ASP30T, ASP35S, ASP7T, CYS147T, CYS8T, GLN106T, GLN162S, GLN164S, GLN178T, GLN195S, GLN196T, GLN19T, GLN205S, GLN20T, GLN240S, GLN248S, GLN261S, GLN4T, GLN5T, GLU113T, GLU12S, GLU159S, GLU200S, GLU218T, GLU221T, GLU230T, GLU236S, GLU238S, GLU245S, GLU28S, GLU31S, GLU99T, GLY114T, GLY115T, GLY138T, GLY139S, GLY140T, GLY146T, GLY171S, GLY183T, GLY185T, GLY190T, GLY191T, GLY202S, GLY214T, GLY234T, GLY242T, GLY27S, HIS135S, HIS152T, HIS161S, HIS197S, HIS209S, HIS209T, HIS23S, ILE132T, ILE134T, ILE144T, ILE16S, ILE194S, ILE210T, ILE212S, ILE213T, ILE21S, ILE21T, ILE224T, ILE231T, ILE239T, ILE243S, ILE269S, ILE274S, ILE29T, LEU10T, LEU110T, LEU12T, LEU16T, LEU175T, LEU177T, LEU189T, LEU192S, LEU193T, LEU206S, LEU216T, LEU228T, LEU243T, LEU258S, LEU25T, LEU262S, LEU275S, LEU28T, LEU31T, LEU35T, LEU38S, LEU39S, LEU39T, LEU40S, LEU45S, LEU46S, LEU6T, LEU96T, LYS133S, LYS135T, LYS136T, LYS13S, LYS142T, LYS143T, LYS145T, LYS181T, LYS193S, LYS19S, LYS210S, LYS223T, LYS235T, LYS237T, LYS23T, LYS256S, LYS268S, LYS273S, MET13T, MET174T, MET187T, MET197T, MET220T, MET250S, PHE104T, PHE112T, PHE163S, PHE168S, PHE20S, PHE233T, PHE255S, PHE29S, PHE33S, PRO137S, PRO165S, PRO17T, PRO18T, PRO208T, PRO25S, PRO263S, PRO26S, PRO33T, SER141T, SER150T, SER160S, SER184T, SER192T, SER204T, SER206T, SER207T, SER208S, SER226T, SER244S, SER251S, SER26T, SER276S, SER34T, SER9S, THR172T, THR179T, THR182T, THR186T, THR194T, THR227T, THR22S, THR236T, THR241S, THR249S, THR253S, THR254S, THR265S, THR267S, TRP148T, TRP169S, TRP173S, TRP176T, TRP271S, TYR107T, TYR111T, TYR131S, TYR136S, TYR198S, TYR199S, TYR232T, TYR239S, TYR247S, VAL132S, VAL14S, VAL173T, VAL196S, VAL204S, VAL207S, VAL217T, VAL240T, VAL264S, VAL32S, VAL32T, VAL36S, VAL8S
• S-U: ALA481U, ALA50S, ALA51S, ARG102S, ARG37S, ARG47S, ASN203S, ASN30S, ASN34S, ASN42S, ASN44S, ASN476U, ASN485U, ASP201S, ASP35S, ASP43S, ASP478U, ASP479U, ASP99S, GLU104S, GLU200S, GLU28S, GLU31S, GLU484U, GLU48S, GLY202S, GLY49S, HIS100S, HIS197S, HIS488U, ILE21S, ILE480U, LEU101S, LEU38S, LEU40S, LEU45S, LEU46S, LEU486U, LEU487U, LEU489U, LYS103S, LYS166S, PHE168S, PHE29S, PHE33S, PHE477U, PHE54S, PRO165S, SER482U, SER483U, THR490U, TYR199S, VAL32S, VAL36S, VAL475U
• S-W: ALA186S, ASP11W, ASP125W, ASP3W, ASP7W, CYS8W, GLN151S, GLN187S, GLN213S, GLN217S, GLN4W, GLN5W, ILE181S, LEU10W, LEU6W, PRO183S, PRO184S, SER215S, SER2W, THR182S, THR185S, VAL218S
• S-X: ALA491X, ASN485X, ASN492X, GLN217S, GLU484X, HIS488X, LEU486X, LEU487X, LEU489X, LYS495X, PRO183S, PRO184S, SER215S, SER219S, SER220S, THR185S, VAL216S
• S-1: ALA130S, ARG2591, ARG2601, ARG2661, ASN138S, ASN234S, ASN237S, ASP134S, ASP2521, ASP71S, GLN162S, GLN164S, GLN240S, GLN2481, GLN2611, GLU233S, GLU236S, GLU238S, GLY139S, HIS135S, ILE229S, LEU2621, LYS133S, LYS226S, LYS230S, LYS2561, LYS2681, PRO137S, PRO2631, SER2511, THR241S, THR2651, THR2671, TYR131S, TYR136S, TYR1981, VAL132S, VAL2641
• S-2: ALA130S, ARG129S, ARG2252, ASN138S, ASN2222, ASN2292, ASP134S, ASP2192, ASP2382, ASP71S, ASP72S, GLU2012, GLU2182, GLU2212, GLU2302, GLY2342, GLY69S, HIS135S, ILE2312, LYS133S, LYS1992, LYS2232, LYS226S, LYS2352, LYS66S, PHE140S, PRO137S, SER126S, SER2262, THR2272, TYR1112, TYR131S, TYR136S, VAL132S, VAL222S
• T-U: ALA129T, ALA491U, ALA87T, ALA9T, ARG14T, ARG15T, ARG195T, ARG493U, ARG499U, ARG500U, ARG66T, ARG72T, ASN485U, ASN492U, ASN65T, ASP11T, ASP123T, ASP38T, ASP44T, ASP63T, ASP67T, ASP69T, ASP7T, ASP85T, CYS36T, CYS62T, CYS8T, GLN196T, GLN45T, GLN4T, GLN5T, GLU155T, GLU37T, GLU484U, GLU84T, GLY130T, GLY498U, GLY503U, GLY68T, GLY86T, HIS152T, HIS488U, ILE151T, ILE29T, LEU10T, LEU121T, LEU124T, LEU12T, LEU133T, LEU169T, LEU193T, LEU35T, LEU39T, LEU40T, LEU486U, LEU487U, LEU489U, LEU501U, LEU6T, LEU83T, LYS168T, LYS495U, MET13T, MET174T, MET197T, MET220T, MET496U, PHE128T, PRO33T, PRO494U, PRO497U, PRO502U, SER171T, SER34T, SER41T, SER42T, SER482U, SER483U, SER70T, THR170T, THR172T, THR194T, THR490U, TRP122T, TYR120T, TYR64T, TYR71T, TYR79T, VAL131T, VAL153T, VAL154T, VAL156T, VAL43T
• T-W: ASP125W, GLU158W, HIS126W, LYS181T, THR182T
• T-Y: ALA9T, ASP11T, ASP125T, ASP211Y, ASP7T, CYS8T, GLN157T, GLN196T, GLN213Y, GLN217Y, GLN4T, GLN5T, GLU238Y, HIS126T, ILE181Y, ILE212Y, LEU10T, LEU6T, LYS168T, LYS210Y, PRO183Y, PRO184Y, SER215Y, SER219Y, THR182Y, THR185Y, VAL218Y
• T-Z: ASP125T, GLU158T, GLY183Z, HIS126T, LYS181Z, THR182Z
• T-1: ARG244T, ARG2601, ARG2661, ASN241T, GLN2611, GLY242T, LEU243T, LEU2621, LYS2561, VAL2641
• T-2: ARG2252, ARG244T
• U-Y: ALA186Y, ALA491U, ASN485U, ASN492U, ASP214Y, GLN187Y, GLN217Y, GLU484U, HIS488U, LEU486U, LEU487U, LEU489U, LYS495U, PRO183Y, PRO184Y, SER215Y, SER219Y, SER220Y, THR185Y, THR490U, VAL216Y, VAL218Y
• V-W: ALA100W, ALA103W, ALA137W, ALA17V, ALA18V, ALA211W, ALA235V, ALA242V, ALA24V, ALA257V, ALA9W, ARG108W, ARG14W, ARG15V, ARG15W, ARG172V, ARG174V, ARG195W, ARG215W, ARG225W, ARG244W, ARG259V, ARG260V, ARG266V, ARG37V, ASN102W, ASN138V, ASN167V, ASN170V, ASN180W, ASN188W, ASN203V, ASN212W, ASN222W, ASN229W, ASN241W, ASN246V, ASN24W, ASN272V, ASN30V, ASN34V, ASN41V, ASN42V, ASP105W, ASP109W, ASP10V, ASP11W, ASP134V, ASP139W, ASP149W, ASP201V, ASP205W, ASP211V, ASP219W, ASP238W, ASP252V, ASP270V, ASP27W, ASP30W, ASP35V, ASP7W, CYS147W, CYS8W, GLN106W, GLN162V, GLN164V, GLN178W, GLN195V, GLN196W, GLN19W, GLN205V, GLN20W, GLN240V, GLN248V, GLN261V, GLN4W, GLN5W, GLU113W, GLU12V, GLU159V, GLU200V, GLU218W, GLU221W, GLU230W, GLU236V, GLU238V, GLU245V, GLU28V, GLU31V, GLU99W, GLY114W, GLY115W, GLY138W, GLY139V, GLY140W, GLY146W, GLY171V, GLY183W, GLY185W, GLY190W, GLY191W, GLY202V, GLY214W, GLY234W, GLY242W, GLY27V, HIS135V, HIS152W, HIS161V, HIS197V, HIS209V, HIS209W, HIS23V, ILE132W, ILE134W, ILE144W, ILE16V, ILE194V, ILE210W, ILE212V, ILE213W, ILE21V, ILE21W, ILE224W, ILE231W, ILE239W, ILE243V, ILE269V, ILE274V, ILE29W, LEU10W, LEU110W, LEU12W, LEU16W, LEU175W, LEU177W, LEU189W, LEU192V, LEU193W, LEU206V, LEU216W, LEU228W, LEU243W, LEU258V, LEU25W, LEU262V, LEU275V, LEU28W, LEU31W, LEU35W, LEU38V, LEU39V, LEU39W, LEU40V, LEU45V, LEU46V, LEU6W, LEU96W, LYS133V, LYS135W, LYS136W, LYS13V, LYS142W, LYS143W, LYS145W, LYS181W, LYS193V, LYS19V, LYS210V, LYS223W, LYS235W, LYS237W, LYS23W, LYS256V, LYS268V, LYS273V, MET13W, MET174W, MET187W, MET197W, MET220W, MET250V, PHE104W, PHE112W, PHE163V, PHE168V, PHE20V, PHE233W, PHE255V, PHE29V, PHE33V, PRO137V, PRO165V, PRO17W, PRO18W, PRO208W, PRO25V, PRO263V, PRO26V, PRO33W, SER141W, SER150W, SER160V, SER171W, SER184W, SER192W, SER204W, SER206W, SER207W, SER208V, SER226W, SER244V, SER251V, SER26W, SER276V, SER2W, SER34W, SER9V, THR172W, THR179W, THR182W, THR186W, THR194W, THR227W, THR22V, THR236W, THR241V, THR249V, THR253V, THR254V, THR265V, THR267V, TRP148W, TRP169V, TRP173V, TRP176W, TRP271V, TYR107W, TYR111W, TYR131V, TYR136V, TYR198V, TYR199V, TYR232W, TYR239V, TYR247V, VAL132V, VAL14V, VAL173W, VAL196V, VAL204V, VAL207V, VAL217W, VAL240W, VAL264V, VAL32V, VAL32W, VAL36V, VAL8V
• V-X: ALA481X, ALA50V, ALA51V, ARG102V, ARG37V, ARG47V, ASN203V, ASN30V, ASN34V, ASN42V, ASN44V, ASN476X, ASN485X, ASP201V, ASP35V, ASP43V, ASP478X, ASP479X, ASP99V, GLU200V, GLU28V, GLU31V, GLU484X, GLU48V, GLY202V, GLY49V, HIS100V, HIS197V, HIS488X, ILE21V, ILE480X, LEU101V, LEU38V, LEU40V, LEU45V, LEU46V, LEU486X, LEU487X, LEU489X, LYS103V, LYS166V, PHE168V, PHE29V, PHE33V, PHE477X, PHE54V, PRO165V, SER482X, SER483X, THR490X, TYR199V, VAL32V, VAL36V, VAL475X
• V-7: ALA130V, ARG2597, ARG2607, ARG2667, ASN138V, ASN234V, ASN237V, ASP134V, ASP2527, ASP71V, GLN162V, GLN164V, GLN240V, GLN2487, GLN2617, GLU233V, GLU236V, GLU238V, GLY139V, HIS135V, ILE229V, LEU2627, LYS133V, LYS226V, LYS230V, LYS2567, LYS2687, PRO137V, PRO2637, THR241V, THR2657, THR2677, TRP173V, TYR131V, TYR136V, TYR1987, VAL132V, VAL2647
• V-8: ARG2258, ASP134V, ASP2198, ASP71V, ASP72V, GLU2188, GLU2308, LYS133V, LYS2358, TYR1118
• W-X: ALA129W, ALA491X, ALA87W, ALA9W, ARG14W, ARG15W, ARG195W, ARG493X, ARG499X, ARG500X, ARG66W, ARG72W, ASN485X, ASN492X, ASN65W, ASP11W, ASP123W, ASP38W, ASP3W, ASP44W, ASP63W, ASP67W, ASP69W, ASP7W, ASP85W, CYS36W, CYS62W, CYS8W, GLN196W, GLN45W, GLN4W, GLN5W, GLU155W, GLU37W, GLU484X, GLU84W, GLY130W, GLY498X, GLY503X, GLY68W, GLY86W, HIS152W, HIS488X, ILE151W, ILE29W, LEU10W, LEU121W, LEU124W, LEU12W, LEU133W, LEU169W, LEU193W, LEU35W, LEU39W, LEU40W, LEU486X, LEU487X, LEU489X, LEU501X, LEU6W, LEU83W, LYS168W, LYS495X, MET13W, MET174W, MET197W, MET220W, MET496X, PHE128W, PRO33W, PRO494X, PRO497X, PRO502X, SER171W, SER34W, SER41W, SER42W, SER482X, SER483X, SER70W, THR170W, THR172W, THR194W, THR490X, TRP122W, TYR120W, TYR64W, TYR71W, TYR79W, VAL131W, VAL153W, VAL154W, VAL156W, VAL43W
• W-7: ARG244W, ARG2607, ARG2667, ASN241W, GLN2617, GLY242W, LEU243W, LEU2627, LYS2567, PRO2637, VAL2647
• Y-Z: ALA100Z, ALA103Z, ALA137Z, ALA17Y, ALA18Y, ALA211Z, ALA235Y, ALA242Y, ALA24Y, ALA257Y, ALA9Z, ARG108Z, ARG14Z, ARG15Y, ARG15Z, ARG172Y, ARG174Y, ARG195Z, ARG215Z, ARG225Z, ARG244Z, ARG259Y, ARG260Y, ARG266Y, ARG37Y, ASN102Z, ASN138Y, ASN167Y, ASN170Y, ASN180Z, ASN188Z, ASN203Y, ASN212Z, ASN222Z, ASN229Z, ASN241Z, ASN246Y, ASN24Z, ASN272Y, ASN30Y, ASN34Y, ASN41Y, ASN42Y, ASP105Z, ASP109Z, ASP10Y, ASP11Z, ASP134Y, ASP139Z, ASP149Z, ASP201Y, ASP205Z, ASP211Y, ASP219Z, ASP238Z, ASP252Y, ASP270Y, ASP27Z, ASP30Z, ASP35Y, ASP7Z, CYS147Z, CYS8Z, GLN106Z, GLN162Y, GLN164Y, GLN178Z, GLN195Y, GLN196Z, GLN19Z, GLN205Y, GLN20Z, GLN240Y, GLN248Y, GLN261Y, GLN4Z, GLN5Z, GLU113Z, GLU12Y, GLU159Y, GLU200Y, GLU218Z, GLU221Z, GLU230Z, GLU236Y, GLU238Y, GLU245Y, GLU28Y, GLU31Y, GLU99Z, GLY114Z, GLY115Z, GLY138Z, GLY139Y, GLY140Z, GLY146Z, GLY171Y, GLY183Z, GLY185Z, GLY190Z, GLY191Z, GLY202Y, GLY214Z, GLY234Z, GLY242Z, GLY27Y, HIS135Y, HIS152Z, HIS161Y, HIS197Y, HIS209Y, HIS209Z, HIS23Y, ILE132Z, ILE134Z, ILE144Z, ILE16Y, ILE194Y, ILE210Z, ILE212Y, ILE213Z, ILE21Y, ILE21Z, ILE224Z, ILE231Z, ILE239Z, ILE243Y, ILE269Y, ILE274Y, ILE29Z, LEU10Z, LEU110Z, LEU12Z, LEU16Z, LEU175Z, LEU177Z, LEU189Z, LEU192Y, LEU193Z, LEU206Y, LEU216Z, LEU228Z, LEU243Z, LEU258Y, LEU25Z, LEU262Y, LEU275Y, LEU28Z, LEU31Z, LEU35Z, LEU38Y, LEU39Y, LEU39Z, LEU40Y, LEU45Y, LEU46Y, LEU6Z, LEU96Z, LYS133Y, LYS135Z, LYS136Z, LYS13Y, LYS142Z, LYS143Z, LYS145Z, LYS181Z, LYS193Y, LYS19Y, LYS210Y, LYS223Z, LYS235Z, LYS237Z, LYS23Z, LYS256Y, LYS268Y, LYS273Y, MET13Z, MET174Z, MET187Z, MET197Z, MET220Z, MET250Y, PHE104Z, PHE112Z, PHE163Y, PHE168Y, PHE20Y, PHE233Z, PHE255Y, PHE29Y, PHE33Y, PRO137Y, PRO165Y, PRO17Z, PRO18Z, PRO208Z, PRO25Y, PRO263Y, PRO26Y, PRO33Z, SER141Z, SER150Z, SER160Y, SER184Z, SER192Z, SER204Z, SER206Z, SER207Z, SER208Y, SER226Z, SER244Y, SER251Y, SER26Z, SER276Y, SER2Z, SER34Z, SER9Y, THR172Z, THR179Z, THR182Z, THR186Z, THR194Z, THR227Z, THR22Y, THR236Z, THR241Y, THR249Y, THR253Y, THR254Y, THR265Y, THR267Y, TRP148Z, TRP169Y, TRP173Y, TRP176Z, TRP271Y, TYR107Z, TYR111Z, TYR136Y, TYR198Y, TYR199Y, TYR232Z, TYR239Y, TYR247Y, VAL132Y, VAL14Y, VAL173Z, VAL196Y, VAL204Y, VAL207Y, VAL217Z, VAL240Z, VAL264Y, VAL32Y, VAL32Z, VAL36Y, VAL8Y
• Y-0: ALA4810, ALA50Y, ALA51Y, ARG102Y, ARG37Y, ARG47Y, ASN203Y, ASN30Y, ASN34Y, ASN42Y, ASN44Y, ASN4760, ASN4850, ASP201Y, ASP35Y, ASP43Y, ASP4780, ASP4790, ASP99Y, GLU104Y, GLU200Y, GLU28Y, GLU31Y, GLU4840, GLU48Y, GLY202Y, GLY49Y, HIS100Y, HIS197Y, HIS4880, ILE21Y, ILE4800, LEU101Y, LEU38Y, LEU40Y, LEU45Y, LEU46Y, LEU4860, LEU4870, LEU4890, LYS103Y, LYS166Y, PHE168Y, PHE29Y, PHE33Y, PHE4770, PHE54Y, PRO165Y, SER4820, SER4830, THR4900, TYR199Y, VAL32Y, VAL36Y, VAL4750
• Y-4: ALA130Y, ARG2594, ARG2604, ARG2664, ASN138Y, ASN234Y, ASN237Y, ASP134Y, ASP2524, GLN162Y, GLN240Y, GLN2484, GLN2614, GLU233Y, GLU236Y, GLU238Y, GLY139Y, HIS135Y, ILE229Y, LEU2624, LYS133Y, LYS226Y, LYS230Y, LYS2564, LYS2684, PRO137Y, PRO2634, THR241Y, THR2654, THR2674, TYR131Y, TYR136Y, VAL132Y, VAL2644
• Y-5: ALA130Y, ARG129Y, ARG2255, ASN138Y, ASN2225, ASN2295, ASP134Y, ASP2195, ASP2385, ASP71Y, ASP72Y, GLU2185, GLU2215, GLU2305, GLY139Y, GLY2345, GLY69Y, HIS135Y, ILE2315, LYS133Y, LYS1995, LYS2235, LYS226Y, LYS2355, LYS66Y, PHE140Y, PRO137Y, SER2265, THR2275, TYR1115, TYR131Y, TYR136Y, VAL132Y, VAL222Y
• Z-0: ALA129Z, ALA4910, ALA87Z, ALA9Z, ARG14Z, ARG15Z, ARG195Z, ARG4930, ARG4990, ARG5000, ARG66Z, ARG72Z, ASN4850, ASN4920, ASN65Z, ASP11Z, ASP123Z, ASP38Z, ASP44Z, ASP63Z, ASP67Z, ASP69Z, ASP7Z, ASP85Z, CYS36Z, CYS62Z, CYS8Z, GLN196Z, GLN45Z, GLN4Z, GLN5Z, GLU155Z, GLU37Z, GLU4840, GLU84Z, GLY130Z, GLY4980, GLY5030, GLY68Z, GLY86Z, HIS152Z, HIS4880, ILE151Z, ILE29Z, LEU10Z, LEU121Z, LEU124Z, LEU12Z, LEU133Z, LEU169Z, LEU193Z, LEU35Z, LEU39Z, LEU40Z, LEU4860, LEU4870, LEU4890, LEU5010, LEU6Z, LEU83Z, LYS168Z, LYS4950, MET13Z, MET174Z, MET197Z, MET220Z, MET4960, PHE128Z, PRO33Z, PRO4940, PRO4970, PRO5020, SER171Z, SER34Z, SER41Z, SER42Z, SER4820, SER4830, SER70Z, THR170Z, THR172Z, THR194Z, THR4900, TRP122Z, TYR120Z, TYR64Z, TYR71Z, TYR79Z, VAL131Z, VAL153Z, VAL154Z, VAL156Z, VAL43Z
• Z-4: ARG244Z, ARG2604, ARG2664, ASN241Z, GLN2614, GLY242Z, LEU243Z, LEU2624, LYS2564, PRO2634, VAL2644
• 1-2: ALA1002, ALA1032, ALA1372, ALA171, ALA181, ALA2112, ALA2351, ALA241, ALA2421, ALA2571, ALA92, ARG1082, ARG142, ARG151, ARG152, ARG1721, ARG1741, ARG1952, ARG2152, ARG2252, ARG2442, ARG2591, ARG2601, ARG371, ASN1022, ASN1381, ASN1671, ASN1701, ASN1802, ASN1882, ASN2031, ASN2122, ASN2222, ASN2292, ASN2412, ASN242, ASN2461, ASN2721, ASN301, ASN341, ASN411, ASN421, ASP101, ASP1052, ASP1092, ASP112, ASP1341, ASP1392, ASP1492, ASP2011, ASP2052, ASP2111, ASP2192, ASP2382, ASP2521, ASP2701, ASP272, ASP302, ASP32, ASP351, ASP72, CYS1472, CYS82, GLN1062, GLN1621, GLN1641, GLN1782, GLN192, GLN1951, GLN1962, GLN202, GLN2051, GLN2401, GLN2481, GLN2611, GLN42, GLN52, GLU1132, GLU121, GLU1591, GLU2001, GLU2182, GLU2212, GLU2302, GLU2361, GLU2381, GLU2451, GLU281, GLU311, GLU992, GLY1142, GLY1152, GLY1382, GLY1391, GLY1402, GLY1462, GLY1711, GLY1832, GLY1852, GLY1902, GLY1912, GLY2021, GLY2142, GLY2342, GLY2422, GLY271, HIS1351, HIS1522, HIS1611, HIS1971, HIS2091, HIS2092, HIS231, ILE1322, ILE1342, ILE1442, ILE161, ILE1941, ILE2102, ILE211, ILE212, ILE2121, ILE2132, ILE2242, ILE2312, ILE2392, ILE2431, ILE2691, ILE2741, ILE292, LEU102, LEU1102, LEU122, LEU162, LEU1752, LEU1772, LEU1892, LEU1921, LEU1932, LEU2061, LEU2162, LEU2282, LEU2432, LEU252, LEU2581, LEU2621, LEU2751, LEU282, LEU312, LEU352, LEU381, LEU391, LEU392, LEU401, LEU451, LEU461, LEU62, LEU962, LYS131, LYS1331, LYS1352, LYS1362, LYS1422, LYS1432, LYS1452, LYS1812, LYS191, LYS1931, LYS2101, LYS2232, LYS232, LYS2352, LYS2372, LYS2561, LYS2681, LYS2731, MET132, MET1742, MET1872, MET1972, MET2202, MET2501, PHE1042, PHE1122, PHE1631, PHE1681, PHE201, PHE2332, PHE2551, PHE291, PHE331, PRO1371, PRO1651, PRO172, PRO182, PRO2082, PRO251, PRO261, PRO2631, PRO332, SER1412, SER1502, SER1601, SER1842, SER1922, SER2062, SER2072, SER2081, SER2262, SER2441, SER2511, SER262, SER2761, SER342, SER91, THR1722, THR1792, THR1822, THR1862, THR1942, THR221, THR2272, THR2362, THR2411, THR2491, THR2531, THR2541, THR2651, THR2671, TRP1482, TRP1691, TRP1731, TRP1762, TRP2711, TYR1072, TYR1112, TYR1311, TYR1361, TYR1981, TYR1991, TYR2322, TYR2391, TYR2471, VAL1321, VAL141, VAL1732, VAL1961, VAL2041, VAL2071, VAL2172, VAL2402, VAL2641, VAL321, VAL322, VAL361, VAL81
• 1-3: ALA4813, ALA501, ALA511, ARG1021, ARG371, ARG471, ASN2031, ASN301, ASN341, ASN421, ASN441, ASN4763, ASN4853, ASP2011, ASP351, ASP431, ASP4783, ASP4793, ASP991, GLU1041, GLU2001, GLU281, GLU311, GLU481, GLU4843, GLY2021, GLY491, HIS1001, HIS1971, HIS4883, ILE211, ILE4803, LEU1011, LEU381, LEU401, LEU451, LEU461, LEU4863, LEU4873, LEU4893, LYS1031, LYS1661, PHE1681, PHE291, PHE331, PHE4773, PHE541, PRO1651, SER4823, SER4833, THR4903, TYR1991, VAL321, VAL361, VAL4753
• 1-5: ALA95, ASP115, ASP1255, ASP2111, ASP75, CYS85, GLN1965, GLN2131, GLN2171, GLN45, GLN55, HIS1265, ILE1811, ILE2121, LEU105, LEU65, LYS1685, LYS2101, PRO1831, PRO1841, SER2151, THR1821, THR1851, VAL2181
• 1-6: ALA1861, ALA4916, ASN4856, ASN4926, ASP2141, GLN1871, GLN2171, GLU4846, HIS4886, LEU4866, LEU4876, LEU4896, LYS4956, PRO1831, PRO1841, SER2151, SER2191, SER2201, THR1851, THR4906, VAL2161, VAL2181
• 2-3: ALA1292, ALA4913, ALA872, ALA92, ARG142, ARG152, ARG1952, ARG4933, ARG4993, ARG5003, ARG662, ARG722, ASN4853, ASN4923, ASN652, ASP112, ASP1232, ASP382, ASP442, ASP632, ASP672, ASP692, ASP72, ASP852, CYS362, CYS622, CYS82, GLN1962, GLN42, GLN452, GLN52, GLU1552, GLU372, GLU4843, GLU842, GLY1302, GLY4983, GLY5033, GLY682, GLY862, HIS1522, HIS4883, ILE1512, ILE292, LEU102, LEU1212, LEU122, LEU1242, LEU1332, LEU1692, LEU1932, LEU352, LEU392, LEU402, LEU4863, LEU4873, LEU4893, LEU5013, LEU62, LEU832, LYS1682, LYS4953, MET132, MET1742, MET1972, MET2202, MET4963, PHE1282, PRO332, PRO4943, PRO4973, PRO5023, SER1712, SER1922, SER342, SER412, SER422, SER4823, SER4833, SER702, THR1702, THR1722, THR1942, THR4903, TRP1222, TYR1202, TYR642, TYR712, TYR792, VAL1312, VAL1532, VAL1542, VAL1562, VAL432
• 2-5: ASP1255, GLU1585, GLY1832, HIS1265, LYS1812, THR1822
• 2-7: ALA92, ASP112, ASP1252, ASP2117, ASP2147, ASP32, ASP382, ASP72, CYS82, GLN1517, GLN1527, GLN1572, GLN1877, GLN1962, GLN2137, GLN2177, GLN42, GLN52, GLU1552, GLU2387, GLY1507, HIS1262, ILE1817, ILE2127, ILE2317, LEU102, LEU62, LYS1682, LYS2107, PRO1837, PRO1847, SER2157, SER2197, SER422, THR1702, THR1807, THR1827, THR1857, VAL2167, VAL2187
• 3-7: ALA1867, ALA4913, ARG4933, ASN4853, ASN4923, ASP2147, GLN1877, GLN2177, GLN2237, GLU4843, HIS4883, LEU4863, LEU4873, LEU4893, LYS4953, PRO1837, PRO1847, SER2157, SER2197, SER2207, THR1827, THR1857, THR4903, VAL2167, VAL2187
• 4-5: ALA1005, ALA1035, ALA1375, ALA174, ALA184, ALA2115, ALA2354, ALA2424, ALA244, ALA2574, ALA95, ARG1085, ARG145, ARG154, ARG155, ARG1724, ARG1744, ARG1955, ARG2155, ARG2255, ARG2445, ARG2594, ARG2604, ARG374, ASN1025, ASN1384, ASN1674, ASN1704, ASN1805, ASN1885, ASN2034, ASN2125, ASN2225, ASN2295, ASN2374, ASN2415, ASN245, ASN2464, ASN2724, ASN304, ASN344, ASN414, ASN424, ASP104, ASP1055, ASP1095, ASP115, ASP1344, ASP1395, ASP1495, ASP2014, ASP2055, ASP2114, ASP2195, ASP2385, ASP2524, ASP2704, ASP275, ASP305, ASP354, ASP75, CYS1475, CYS85, GLN1065, GLN1624, GLN1644, GLN1785, GLN195, GLN1954, GLN1965, GLN205, GLN2054, GLN2404, GLN2484, GLN2614, GLN45, GLN55, GLU1135, GLU124, GLU1594, GLU2004, GLU2185, GLU2215, GLU2305, GLU2364, GLU2384, GLU2454, GLU284, GLU314, GLU995, GLY1145, GLY1155, GLY1385, GLY1394, GLY1405, GLY1465, GLY1714, GLY1835, GLY1855, GLY1905, GLY1915, GLY2024, GLY2145, GLY2345, GLY2425, GLY274, HIS1354, HIS1525, HIS1614, HIS1974, HIS2094, HIS2095, HIS234, ILE1325, ILE1345, ILE1445, ILE164, ILE1944, ILE2105, ILE2124, ILE2135, ILE214, ILE215, ILE2245, ILE2315, ILE2395, ILE2434, ILE2694, ILE2744, ILE295, LEU105, LEU1105, LEU125, LEU165, LEU1755, LEU1775, LEU1895, LEU1924, LEU1935, LEU2064, LEU2165, LEU2285, LEU2435, LEU255, LEU2584, LEU2624, LEU2754, LEU285, LEU315, LEU355, LEU384, LEU394, LEU395, LEU404, LEU454, LEU464, LEU65, LEU965, LYS1334, LYS134, LYS1355, LYS1365, LYS1425, LYS1435, LYS1455, LYS1815, LYS1934, LYS194, LYS2104, LYS2235, LYS235, LYS2355, LYS2375, LYS2564, LYS2684, LYS2734, MET135, MET1745, MET1875, MET1975, MET2205, MET2504, PHE1045, PHE1125, PHE1634, PHE1684, PHE204, PHE2335, PHE2554, PHE294, PHE334, PRO1374, PRO1654, PRO175, PRO185, PRO2085, PRO254, PRO2634, PRO264, PRO335, SER1415, SER1505, SER1604, SER1845, SER1925, SER2065, SER2075, SER2084, SER2265, SER2444, SER2514, SER265, SER2764, SER345, SER94, THR1725, THR1795, THR1825, THR1865, THR1945, THR224, THR2275, THR2365, THR2414, THR2494, THR2534, THR2544, THR2654, THR2674, TRP1485, TRP1694, TRP1734, TRP1765, TRP2714, TYR1075, TYR1115, TYR1314, TYR1364, TYR1984, TYR1994, TYR2325, TYR2394, TYR2474, VAL1324, VAL144, VAL1735, VAL1964, VAL2044, VAL2074, VAL2175, VAL2405, VAL2644, VAL324, VAL325, VAL364, VAL84
• 4-6: ALA4816, ALA504, ALA514, ARG1024, ARG374, ARG474, ASN2034, ASN304, ASN344, ASN424, ASN444, ASN4766, ASN4856, ASP2014, ASP354, ASP434, ASP4786, ASP4796, ASP994, GLU1044, GLU2004, GLU284, GLU314, GLU484, GLU4846, GLY2024, GLY494, HIS1004, HIS1974, HIS4886, ILE214, ILE4806, LEU1014, LEU384, LEU404, LEU454, LEU464, LEU4866, LEU4876, LEU4896, LYS1034, LYS1664, PHE1684, PHE294, PHE334, PHE4776, PHE544, PRO1654, SER4826, SER4836, THR4906, TYR1994, VAL324, VAL364, VAL4756
• 5-6: ALA1295, ALA4916, ALA875, ALA95, ARG145, ARG155, ARG1955, ARG4936, ARG4996, ARG5006, ARG665, ARG725, ASN4856, ASN4926, ASN655, ASP115, ASP1235, ASP385, ASP445, ASP635, ASP675, ASP695, ASP75, ASP855, CYS365, CYS625, CYS85, GLN1965, GLN45, GLN455, GLN55, GLU1555, GLU375, GLU4846, GLU845, GLY1305, GLY4986, GLY5036, GLY685, GLY865, HIS1525, HIS4886, ILE1515, ILE295, LEU105, LEU1215, LEU1245, LEU125, LEU1335, LEU1695, LEU1935, LEU355, LEU395, LEU405, LEU4866, LEU4876, LEU4896, LEU5016, LEU65, LEU835, LYS1685, LYS4956, MET135, MET1745, MET1975, MET2205, MET4966, PHE1285, PRO335, PRO4946, PRO4976, PRO5026, SER1715, SER1925, SER345, SER415, SER425, SER4826, SER4836, SER705, THR1705, THR1725, THR1945, THR4906, TRP1225, TYR1205, TYR645, TYR715, TYR795, VAL1315, VAL1535, VAL1545, VAL1565, VAL435
• 7-8: ALA1008, ALA1038, ALA1378, ALA177, ALA187, ALA247, ALA2577, ALA98, ARG1088, ARG148, ARG157, ARG158, ARG1958, ARG2158, ARG2258, ARG2448, ARG2597, ARG2607, ARG377, ASN1028, ASN1707, ASN1888, ASN2037, ASN2467, ASN248, ASN307, ASN347, ASN417, ASN427, ASP1058, ASP107, ASP1098, ASP118, ASP1347, ASP1398, ASP1498, ASP2017, ASP2198, ASP2527, ASP2707, ASP278, ASP308, ASP357, ASP78, CYS1478, CYS88, GLN1068, GLN1957, GLN198, GLN2057, GLN208, GLN2487, GLN2617, GLN48, GLN58, GLU1138, GLU127, GLU2007, GLU2188, GLU2218, GLU2457, GLU287, GLU317, GLU998, GLY1148, GLY1158, GLY1388, GLY1408, GLY1468, GLY1838, GLY1908, GLY2027, GLY277, HIS1357, HIS1528, HIS1977, HIS2097, HIS237, ILE1328, ILE1348, ILE1448, ILE167, ILE217, ILE218, ILE2697, ILE2747, ILE298, LEU108, LEU1108, LEU128, LEU168, LEU2067, LEU258, LEU2587, LEU2627, LEU2757, LEU288, LEU318, LEU358, LEU387, LEU397, LEU398, LEU407, LEU457, LEU467, LEU68, LEU968, LYS1358, LYS1368, LYS137, LYS1428, LYS1438, LYS1458, LYS1818, LYS197, LYS2107, LYS2358, LYS238, LYS2567, LYS2687, LYS2737, MET138, MET2507, PHE1048, PHE1128, PHE1687, PHE207, PHE2557, PHE297, PHE337, PRO1657, PRO178, PRO188, PRO257, PRO2637, PRO267, PRO338, SER1418, SER1508, SER1848, SER1928, SER2517, SER268, SER2767, SER28, SER348, SER97, THR1868, THR1948, THR227, THR2497, THR2537, THR2547, THR2657, THR2677, TRP1488, TRP2717, TYR1078, TYR1118, TYR1987, TYR1997, TYR2477, VAL147, VAL1967, VAL2047, VAL2077, VAL2647, VAL327, VAL328, VAL367, VAL87
• 7-9: ALA4819, ARG1027, ARG377, ARG477, ASN307, ASP2017, ASP437, ASP4789, ASP4799, ASP997, GLU317, GLU4849, HIS4889, VAL4759
• 8-9: ARG148, ARG4939, ARG4999, ARG5009, ARG668, ASN4859, ASP118, ASP388, ASP448, ASP638, ASP678, ASP78, ASP858, GLU1558, GLU378, GLU4849, GLY688, HIS4889, LEU4879, LYS4959, SER418, SER428, THR4909