3LBL

structure of human mdm2 protein in complex with mi-63-analog

• Total interactions analyzed: 3
• Total true interactions: 3
• Strongest Interaction:
  • Chains: A-E
  • Int. Res.: 60
  • Norm. En. per Res.: -3.1525
• Hub Node: A(2)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-C	-11.2353	-4.1812	-37.0664	-52.4828	19	2	0	1587	2	9	9
A-E	-31.071	19.1597	-177.24	-189.1513	60	11	4	6559	0	9	11
C-E	-10.0224	13.4068	-51.6883	-48.3039	35	1	2	2777	2	10	11

Interface residues

• A-C: ALA43A, ALA43C, ARG29C, ASP46A, ASP46C, GLN44A, GLN44C, LEU27A, LEU35A, LEU35C, LYS39A, LYS39C, LYS45A, LYS45C, THR47A, THR47C, TYR48A, TYR48C, TYR56A
• A-E: ALA21E, ALA43A, ARG105E, ARG65A, ARG97E, ASN106E, GLN24A, GLN24E, GLN44A, GLN59A, GLU23E, GLU25A, GLU25E, GLU52A, GLY42A, GLY58A, GLY87E, HIS96E, ILE103E, ILE19E, ILE61A, ILE99E, LEU107E, LEU27E, LEU37A, LEU38A, LEU54A, LEU66A, LEU85E, LYS31E, LYS39A, LYS45A, LYS51A, LYS64A, LYS98E, MET102E, MET50A, MET50E, MET62A, PHE55A, PHE86E, PRO20E, SER22E, SER40A, THR101E, THR26E, THR49A, THR63A, TYR100E, TYR104E, TYR48A, TYR56A, TYR60A, TYR67A, VAL108E, VAL109E, VAL110E, VAL28E, VAL41A, VAL53A
• C-E: ARG29C, ARG29E, ASP46C, ASP46E, GLN24C, GLN24E, GLN44C, GLU25C, GLU25E, GLU52C, GLU52E, LEU27C, LEU27E, LYS45C, LYS45E, LYS51C, LYS51E, MET50E, SER22C, SER22E, THR26C, THR26E, THR47C, THR47E, THR49C, THR49E, TYR48C, TYR48E, TYR56C, TYR56E, VAL109C, VAL110C, VAL110E, VAL28C, VAL28E