3L7F

structure of il-13 antibody h2l6, a humanized variant of c836

• Total interactions analyzed: 15
• Total true interactions: 9
• Strongest Interaction:
  • Chains: L-E
  • Int. Res.: 18
  • Norm. En. per Res.: -5.1028
• Hub Node: L(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
L-H	-41.897	-45.898	-487.037	-574.832	185	14	12	19190	3	26	20
L-A	-6.1875	13.0794	-81.4936	-74.6017	49	4	0	3485	0	7	9
L-D	-3.9916	13.5415	-78.3272	-68.7772	48	5	0	3505	0	6	8
L-E	-13.0416	-48.7838	-30.0259	-91.8513	18	3	0	887	4	5	2
H-A	-5.3998	-41.6511	-33.8318	-80.8826	20	2	0	908	3	6	3
A-B	-21.3495	-52.6004	-503.58	-577.5299	192	26	13	19637	4	24	21
A-D	-5.274	14.6167	-75.3945	-66.0518	49	4	0	3489	0	6	8
B-D	-11.9022	-43.0099	-23.7794	-78.6915	20	3	0	954	4	7	3
D-E	-22.6705	-44.2616	-537.026	-603.9581	193	23	14	20729	3	23	20

Interface residues

• L-H: ALA130L, ALA133H, ALA144H, ALA145H, ALA176H, ALA34L, ALA43L, ALA46H, ALA51H, ALA64H, ALA98H, ARG142L, ARG40H, ARG45L, ARG60H, ARG99H, ASN137L, ASN138L, ASN210L, ASN62H, ASN92L, ASP105H, ASP109H, ASP122L, ASP152H, ASP167L, ASP170L, CYS134L, CYS148H, CYS88L, CYS97H, GLN100L, GLN113H, GLN124L, GLN160L, GLN166L, GLN179H, GLN37L, GLN38L, GLN41H, GLN42L, GLN55L, GLN6L, GLN89L, GLN90L, GLU123L, GLU161L, GLU165L, GLU1L, GLU213L, GLU48H, GLU6H, GLU93L, GLY101H, GLY101L, GLY112H, GLY114H, GLY141H, GLY147H, GLY170H, GLY212L, GLY41L, GLY44H, GLY99L, HIS172H, HIS52H, HIS91L, ILE117L, ILE39H, ILE48L, LEU125L, LEU132H, LEU135L, LEU136L, LEU146H, LEU149H, LEU175L, LEU178H, LEU186H, LEU33L, LEU46L, LEU47H, LEU47L, LEU50H, LEU65H, LYS103L, LYS126L, LYS137H, LYS151H, LYS169L, LYS207L, LYS217H, LYS222H, LYS31L, LYS39L, LYS45H, LYS59H, LYS66H, MET100H, PHE108H, PHE116L, PHE118L, PHE130H, PHE139L, PHE174H, PHE209L, PHE98L, PRO119L, PRO120L, PRO131H, PRO134H, PRO175H, PRO40L, PRO44L, PRO63H, PRO95L, SER102H, SER114L, SER121L, SER127L, SER128H, SER131L, SER135H, SER136H, SER138H, SER140H, SER159L, SER162L, SER168L, SER169H, SER174L, SER176L, SER177L, SER180H, SER185H, SER187H, SER188H, SER208L, SER50L, SER56L, THR129L, THR139H, THR143H, THR164L, THR172L, THR173H, THR178L, THR180L, THR191H, THR53L, THR94H, THR97L, TRP107H, TRP111H, TRP35L, TRP38H, TRP49H, TRP54H, TYR104H, TYR110H, TYR173L, TYR192L, TYR32L, TYR36L, TYR49L, TYR61H, TYR86L, TYR87L, TYR94L, TYR96H, TYR96L, VAL106H, VAL115L, VAL129H, VAL132L, VAL133L, VAL163L, VAL171H, VAL177H, VAL189H, VAL190H, VAL191L, VAL192H, VAL219H, VAL85L
• L-A: ALA19A, ALA60A, ARG18A, ARG61A, ASN92L, ASP70A, ASP70L, CYS23A, GLN90L, GLU17A, GLU93L, GLY51L, GLY64A, GLY66A, GLY66L, GLY68L, HIS91L, ILE29L, ILE2L, ILE75A, LEU11A, LEU13A, LEU21A, LEU33L, LEU73A, LYS27L, LYS31L, PHE62A, PHE71A, PHE71L, PRO8A, SER22A, SER28L, SER30L, SER50L, SER52A, SER63A, SER65A, SER67A, SER67L, SER76A, SER7A, THR20A, THR69L, THR72A, THR74A, TYR32L, TYR94L, TYR96L
• L-D: ALA19L, ALA60L, ARG18L, ARG61L, ASN92D, ASP70D, ASP70L, CYS23L, GLU17L, GLU93D, GLY64L, GLY66D, GLY66L, GLY68D, HIS91D, ILE29D, ILE2D, ILE75L, LEU11L, LEU13L, LEU21L, LEU33D, LEU73L, LYS27D, LYS31D, PHE62L, PHE71D, PHE71L, PRO8L, SER22L, SER28D, SER30D, SER50D, SER52L, SER63L, SER65L, SER67D, SER67L, SER76L, SER7L, THR20L, THR69D, THR72L, THR74L, TRP35L, TYR32D, TYR94D, TYR96D
• L-E: ALA19L, ARG18L, ARG60E, ARG61L, ASP105E, GLU17L, GLY16L, ILE75L, LEU78L, PRO15L, SER102E, SER14L, SER76L, SER77L, THR74L, TRP107E, TYR104E, VAL106E
• H-A: ALA19A, ARG18A, ARG60H, ARG61A, ASP103H, ASP105H, GLU17A, GLY16A, ILE75A, LEU78A, PRO15A, SER102H, SER14A, SER76A, SER77A, THR74A, TRP107H, TYR104H, TYR32H, VAL106H
• A-B: ALA130A, ALA133B, ALA144B, ALA145B, ALA176B, ALA34A, ALA43A, ALA46B, ALA51B, ALA64B, ALA98B, ARG142A, ARG211A, ARG40B, ARG45A, ARG60B, ARG99B, ASN137A, ASN138A, ASN210A, ASN62B, ASN92A, ASP105B, ASP109B, ASP122A, ASP152B, ASP167A, ASP170A, CYS134A, CYS148B, CYS88A, CYS97B, GLN100A, GLN113B, GLN124A, GLN160A, GLN179B, GLN37A, GLN38A, GLN41B, GLN42A, GLN55A, GLN6A, GLN89A, GLN90A, GLU123A, GLU161A, GLU165A, GLU1A, GLU213A, GLU48B, GLU6B, GLU93A, GLY101A, GLY101B, GLY112B, GLY114B, GLY128A, GLY141B, GLY147B, GLY170B, GLY212A, GLY41A, GLY44B, GLY99A, HIS172B, HIS52B, HIS91A, ILE117A, ILE39B, ILE48A, LEU125A, LEU132B, LEU135A, LEU136A, LEU146B, LEU149B, LEU175A, LEU178B, LEU179A, LEU181A, LEU183B, LEU186B, LEU33A, LEU46A, LEU47A, LEU47B, LEU50B, LYS103A, LYS126A, LYS137B, LYS151B, LYS169A, LYS207A, LYS217B, LYS218B, LYS31A, LYS39A, LYS45B, LYS59B, LYS66B, MET100B, PHE108B, PHE116A, PHE118A, PHE130B, PHE139A, PHE174B, PHE209A, PHE98A, PRO119A, PRO120A, PRO131B, PRO134B, PRO175B, PRO221B, PRO40A, PRO42B, PRO44A, PRO63B, PRO95A, SER102B, SER114A, SER121A, SER127A, SER128B, SER131A, SER135B, SER136B, SER138B, SER140B, SER159A, SER162A, SER168A, SER169B, SER174A, SER176A, SER177A, SER180B, SER181B, SER185B, SER187B, SER188B, SER208A, SER50A, SER56A, THR129A, THR139B, THR143B, THR164A, THR172A, THR173B, THR178A, THR180A, THR191B, THR53A, THR94B, THR97A, TRP107B, TRP111B, TRP35A, TRP38B, TRP49B, TRP54B, TYR104B, TYR110B, TYR173A, TYR184B, TYR192A, TYR32A, TYR36A, TYR49A, TYR61B, TYR86A, TYR87A, TYR94A, TYR96A, TYR96B, VAL106B, VAL115A, VAL129B, VAL132A, VAL133A, VAL150B, VAL163A, VAL171B, VAL177B, VAL189B, VAL190B, VAL192B, VAL219B, VAL85A
• A-D: ALA19D, ALA60D, ARG18D, ARG61D, ASN92A, ASP70A, ASP70D, CYS23D, GLN90A, GLU17D, GLU93A, GLY64D, GLY66A, GLY66D, GLY68A, HIS91A, ILE29A, ILE2A, ILE75D, LEU11D, LEU13D, LEU21D, LEU33A, LEU73D, LYS27A, LYS31A, PHE62D, PHE71A, PHE71D, PRO8D, SER22D, SER28A, SER30A, SER50A, SER52D, SER63D, SER65D, SER67A, SER67D, SER76D, SER7D, THR20D, THR69A, THR69D, THR72D, THR74D, TYR32A, TYR94A, TYR96A
• B-D: ALA19D, ARG18D, ARG60B, ARG61D, ASP105B, GLU17D, GLY16D, HIS52B, ILE75D, LEU78D, PRO15D, SER102B, SER14D, SER76D, SER77D, THR74D, TRP107B, TYR104B, VAL106B, VAL58B
• D-E: ALA130D, ALA133E, ALA144E, ALA145E, ALA176E, ALA34D, ALA43D, ALA46E, ALA51E, ALA64E, ALA98E, ARG142D, ARG211D, ARG40E, ARG45D, ARG60E, ARG99E, ASN137D, ASN138D, ASN210D, ASN62E, ASN92D, ASP105E, ASP109E, ASP122D, ASP152E, ASP167D, ASP170D, CYS134D, CYS148E, CYS88D, CYS97E, GLN100D, GLN113E, GLN124D, GLN160D, GLN179E, GLN37D, GLN38D, GLN41E, GLN42D, GLN55D, GLN6D, GLN89D, GLN90D, GLU123D, GLU161D, GLU165D, GLU1D, GLU213D, GLU48E, GLU6E, GLU93D, GLY101D, GLY101E, GLY112E, GLY114E, GLY141E, GLY142E, GLY147E, GLY170E, GLY212D, GLY41D, GLY44E, GLY99D, HIS172E, HIS52E, HIS91D, ILE117D, ILE39E, ILE48D, LEU125D, LEU132E, LEU135D, LEU136D, LEU146E, LEU149E, LEU175D, LEU178E, LEU179D, LEU181D, LEU183E, LEU186E, LEU33D, LEU46D, LEU47D, LEU47E, LEU50E, LEU65E, LYS103D, LYS126D, LYS137E, LYS151E, LYS169D, LYS207D, LYS217E, LYS218E, LYS31D, LYS39D, LYS45E, LYS59E, LYS66E, MET100E, PHE108E, PHE116D, PHE118D, PHE130E, PHE139D, PHE174E, PHE209D, PHE98D, PRO119D, PRO120D, PRO131E, PRO134E, PRO175E, PRO221E, PRO40D, PRO42E, PRO44D, PRO63E, PRO95D, SER102E, SER114D, SER121D, SER127D, SER128E, SER131D, SER135E, SER136E, SER138E, SER140E, SER162D, SER168D, SER174D, SER176D, SER177D, SER180E, SER181E, SER185E, SER187E, SER188E, SER194E, SER208D, SER50D, SER56D, THR129D, THR139E, THR143E, THR164D, THR172D, THR173E, THR178D, THR180D, THR191E, THR53D, THR94E, THR97D, TRP107E, TRP111E, TRP35D, TRP38E, TRP49E, TRP54E, TYR104E, TYR110E, TYR173D, TYR184E, TYR192D, TYR32D, TYR36D, TYR49D, TYR61E, TYR86D, TYR87D, TYR94D, TYR96D, TYR96E, VAL106E, VAL115D, VAL129E, VAL132D, VAL133D, VAL150E, VAL163D, VAL171E, VAL177E, VAL189E, VAL190E, VAL192E, VAL215E, VAL219E, VAL85D