3L71

cytochrome bc1 complex from chicken with azoxystrobin bound

• Total interactions analyzed: 190
• Total true interactions: 67
• Strongest Interaction:
  • Chains: G-H
  • Int. Res.: 32
  • Norm. En. per Res.: -8.5215
• Hub Node: A(9)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-119.0463	-66.6027	-491.547	-677.196	215	35	13	20540	6	59	54
A-C	-33.2025	-32.8273	-94.63	-160.6597	51	9	0	4257	4	19	20
A-D	-2.1224	-1.5143	-16.0162	-19.6529	32	0	1	969	0	15	14
A-E	-83.658	-0.083	-245.889	-329.63	104	13	4	9808	2	27	25
A-F	0.0	3.1814	-0.3348	2.8466	11	0	0	104	0	6	9
A-G	-125.801	-57.7482	-242.837	-426.3862	68	19	4	9189	2	16	9
A-I	-49.1014	19.6409	-188.509	-217.9694	81	23	2	8167	0	11	12
A-J	-5.8306	-6.7727	-35.7089	-48.3123	23	1	0	1574	0	5	9
A-S	0.0	5.9625	-4.3118	1.6507	17	0	0	331	0	12	14
B-I	-64.1139	-10.5287	-399.888	-474.5306	171	41	17	18076	0	13	24
B-O	-15.4547	-51.3161	-191.337	-258.1079	90	5	0	6190	6	33	24
B-S	-8.6571	-42.3757	-102.991	-154.0237	45	1	0	3660	3	23	21
B-V	0.0	0.0	-0.2416	-0.2416	3	0	0	45	0	0	0
C-D	-16.0058	-37.2564	-390.264	-443.5262	152	9	6	15349	4	26	22
C-E	-14.2806	-15.9608	-121.24	-151.4814	49	9	1	5040	2	3	0
C-F	-33.3199	-5.3802	-334.532	-373.232	111	22	6	13527	1	40	21
C-G	0.0	-7.9773	-216.091	-224.0683	106	11	7	9421	0	15	13
C-J	0.0	0.0	-0.0102	-0.0102	2	0	0	5	0	0	0
C-P	-3.1043	7.7812	-211.912	-207.2351	109	2	8	9680	0	18	11
C-R	-9.8496	0.0	-137.73	-147.5796	65	4	3	5360	0	5	5
D-E	-3.9243	-36.5665	-173.149	-213.6398	98	11	11	7210	1	16	28
D-F	-18.3858	-19.7708	-106.79	-144.9467	40	4	2	4009	1	9	20
D-G	-67.9966	-4.1596	-210.672	-282.8283	58	11	4	7955	0	18	14
D-H	-52.3827	-1.4687	-313.083	-366.9344	111	11	7	12967	0	17	25
D-J	-51.8701	-23.2845	-246.631	-321.7855	84	11	6	9282	2	47	51
D-Q	-6.6694	12.6462	-84.9642	-78.9874	39	2	0	2856	0	6	8
D-R	0.0	0.0	-3.2645	-3.2645	17	0	0	300	0	5	3
E-F	0.0	0.0	-0.1123	-0.1123	4	0	0	38	0	0	0
E-G	-34.9444	-50.8376	-175.858	-261.6399	46	4	4	6034	2	10	12
E-J	-6.897	-56.4479	-196.009	-259.3538	60	8	17	7131	4	8	7
E-P	-14.8869	0.0	-131.904	-146.7909	68	3	2	5101	0	6	5
E-Q	0.0	0.0	-1.0297	-1.0297	14	0	0	184	0	5	2
E-U	0.0	0.0	-0.0014	-0.0014	2	0	0	1	0	1	0
F-G	-14.6575	-46.0571	-82.7627	-143.4773	54	9	1	3966	3	13	24
F-N	0.0	6.0567	-5.1426	0.9141	17	0	0	337	0	12	14
F-O	-7.5597	-45.5921	-107.82	-160.9718	45	1	0	3581	3	24	21
G-H	-52.8104	-102.9529	-116.924	-272.6873	32	8	0	3753	8	27	16
G-J	0.0	0.0	-0.0092	-0.0092	2	0	0	6	0	0	0
H-J	0.0	0.0	-0.0004	-0.0004	2	0	0	1	0	0	3
I-O	0.0	0.0	-0.501	-0.501	8	0	0	92	0	0	0
I-V	0.0	0.0	-6.9986	-6.9986	6	2	0	237	0	0	0
N-O	-106.2787	-67.2858	-476.398	-649.9625	211	46	12	20399	6	60	54
N-P	-27.8238	-32.8383	-95.43	-156.0922	50	11	0	4161	4	19	20
N-Q	-2.3078	-1.442	-15.5412	-19.2909	33	0	1	934	0	14	14
N-R	-71.6918	-4.9324	-240.52	-317.1442	105	15	4	9786	2	27	25
N-S	0.0	3.1042	-0.3006	2.8036	11	0	0	96	0	6	8
N-T	-132.54	-58.9164	-249.878	-441.3344	68	18	4	9158	2	16	9
N-V	-37.0108	21.5163	-202.792	-218.2865	82	29	1	8487	0	11	11
N-W	-5.4444	-6.7108	-37.4648	-49.62	23	1	0	1656	0	5	9
O-V	-66.157	-1.8806	-417.838	-485.8755	169	45	19	18818	0	14	24
P-Q	-17.3563	-72.7227	-377.657	-467.7361	151	14	6	15182	4	25	21
P-R	-9.7756	-15.2264	-114.429	-139.4309	49	7	1	5056	2	3	0
P-S	-35.8097	-3.1031	-330.5	-369.4128	111	24	6	13567	1	39	21
P-T	0.0	-7.7385	-223.5	-231.2385	107	10	7	9518	0	15	13
P-W	0.0	0.0	-0.0121	-0.0121	2	0	0	7	0	0	0
Q-R	-13.8289	-40.4134	-167.127	-221.3692	100	12	11	7265	1	20	28
Q-S	-23.0593	-22.9507	-106.977	-152.987	39	9	2	4236	1	9	22
Q-T	-60.9249	-4.2446	-189.571	-254.7404	57	12	4	7573	0	18	14
Q-U	-64.602	2.4184	-307.733	-369.9165	113	14	7	12962	0	19	28
Q-W	-56.303	-58.5565	-251.892	-366.7515	80	13	7	9342	2	43	42
R-S	0.0	0.0	-0.1457	-0.1457	4	0	0	36	0	0	0
R-T	-34.3096	-53.6062	-170.401	-258.3168	49	5	4	5979	3	10	12
R-W	-3.8785	-54.9418	-203.666	-262.4863	61	7	17	7232	4	8	7
S-T	-16.3143	-47.0183	-79.3826	-142.7153	53	7	1	3906	3	13	24
T-U	-36.1243	-115.3113	-86.429	-237.8645	31	10	0	2934	8	27	15
T-W	0.0	0.0	-0.016	-0.016	2	0	0	9	0	0	0
U-W	0.0	0.0	-0.0776	-0.0776	2	0	0	27	0	0	2

Interface residues

• A-B: ALA101A, ALA149B, ALA151B, ALA1A, ALA200A, ALA21B, ALA281B, ALA295A, ALA296A, ALA2A, ALA357A, ALA360B, ALA364A, ALA366B, ALA367A, ALA375B, ALA44B, ALA5A, ALA63A, ALA73A, ALA74A, ALA84A, ALA91B, ALA96A, ARG113B, ARG279A, ARG282A, ARG287B, ARG293A, ARG356A, ARG362A, ARG46B, ARG70B, ARG84B, ARG87B, ASN10A, ASN359A, ASN362B, ASN40B, ASN87A, ASP105A, ASP114B, ASP139B, ASP147B, ASP215B, ASP281A, ASP356B, ASP370A, ASP396A, CYS111B, CYS35A, CYS72A, GLN126A, GLN136A, GLN143B, GLN153B, GLN297B, GLN32A, GLN363B, GLN376B, GLN6A, GLN9A, GLU110B, GLU130A, GLU136B, GLU137A, GLU140A, GLU168A, GLU355B, GLU373B, GLU39B, GLU60A, GLU76A, GLU78A, GLU80A, GLU90B, GLY201A, GLY20B, GLY210B, GLY282B, GLY285A, GLY286A, GLY287A, GLY288B, GLY371A, GLY377B, GLY66A, GLY83A, GLY88A, GLY88B, GLY93B, GLY94B, HIS115B, HIS213B, HIS277B, HIS289A, HIS305A, HIS360A, HIS61A, HIS85A, ILE11A, ILE134A, ILE285B, ILE399A, ILE85B, ILE89B, ILE99A, LEU102A, LEU112A, LEU112B, LEU140B, LEU252B, LEU284B, LEU290A, LEU361A, LEU364B, LEU369A, LEU369B, LEU378B, LEU392A, LEU62A, LEU71B, LEU75B, LEU8A, LEU96B, LYS100A, LYS104A, LYS129A, LYS145B, LYS148B, LYS212B, LYS286B, LYS288A, LYS302A, LYS355A, LYS358A, LYS359B, LYS361B, LYS365B, LYS65A, LYS77A, MET141A, MET365A, MET370B, MET82A, PHE284A, PHE41B, PHE58A, PHE64A, PHE75A, PHE83B, PHE86A, PHE97A, PRO12A, PRO283B, PRO306B, PRO33A, PRO374A, PRO395B, PRO43B, PRO74B, SER103A, SER214B, SER289B, SER290B, SER291A, SER292A, SER293B, SER30A, SER31A, SER352A, SER363A, SER371B, SER42B, SER45B, SER73B, SER81A, SER81B, SER82B, SER95B, SER97B, THR283A, THR292B, THR34A, THR358B, THR367B, THR36A, THR372A, THR373A, THR374B, THR3A, THR76B, THR7A, THR86B, THR90A, TRP135B, TYR280A, TYR368B, TYR4A, TYR57A, TYR89A, TYR98A, VAL116B, VAL133A, VAL146B, VAL150B, VAL211B, VAL291B, VAL299A, VAL366A, VAL372B, VAL375A, VAL59A, VAL79A, VAL92B
• A-C: ALA24C, ALA2C, ARG242A, ARG244A, ARG436A, ARG438A, ARG6C, ASN16C, ASN435A, ASN4C, ASP215C, ASP217C, ASP21C, ASP246A, ASP332A, ASP333A, ASP433A, CYS337A, GLN430A, GLU300A, GLU429A, HIS222C, HIS301A, ILE20C, ILE219C, ILE331A, ILE437A, ILE5C, LEU19C, LEU22C, LEU297A, LEU303A, LEU329A, LEU432A, LYS218C, LYS7C, MET1C, MET334A, PHE221C, PHE336A, PRO220C, PRO223C, PRO23C, PRO3C, SER216C, SER26C, SER330A, SER439A, TYR224C, TYR434A, TYR442A
• A-D: ALA236D, ALA243A, ARG233D, ARG238D, ARG242A, ARG244A, ARG436A, ARG438A, ASN435A, ASP142A, ASP245A, ASP433A, GLU240A, HIS225D, ILE241A, LEU230D, LEU432A, LYS223D, LYS226D, LYS231D, LYS234D, MET235D, PRO240D, SER228D, SER239A, SER439A, THR170A, TRP227D, TYR152A, TYR434A, TYR442A, VAL229D
• A-E: ALA155A, ALA157A, ALA162A, ALA164A, ALA21E, ALA243A, ARG14E, ARG15E, ARG165A, ARG233A, ARG235A, ARG32E, ARG438A, ARG46A, ARG92A, ASN143A, ASN147A, ASN173A, ASN3E, ASN53A, ASP142A, ASP144A, ASP151A, ASP17E, ASP20E, ASP316A, ASP417A, ASP4E, ASP9E, CYS234A, CYS419A, GLN136A, GLN159A, GLN26E, GLU137A, GLU140A, GLU168A, GLU172A, GLU240A, GLU258A, GLU30E, GLU50A, GLY160A, GLY169A, GLY238A, GLY259A, HIS154A, HIS2E, ILE134A, ILE174A, ILE241A, ILE415A, LEU135A, LEU138A, LEU153A, LEU231A, LYS139A, LYS33E, LYS413A, LYS418A, MET141A, MET145A, MET19E, MET441A, PHE10E, PHE150A, PHE158A, PHE236A, PRO232A, PRO260A, PRO8E, SER11E, SER239A, SER24E, SER25E, SER29E, SER36E, SER439A, THR149A, THR156A, THR161A, THR166A, THR170A, THR171A, THR22E, THR237A, THR23E, THR27E, THR317A, THR40E, THR6E, TYR152A, TYR37E, TYR414A, TYR416A, TYR442A, VAL148A, VAL167A, VAL18E, VAL1E, VAL257A, VAL425A, VAL5E, VAL7E
• A-F: ALA247A, ARG242A, ARG244A, ASN56F, ASP245A, ASP246A, GLU52F, LEU432A, LYS63F, MET59F, TYR55F
• A-G: ALA155A, ALA243A, ALA247A, ALA421A, ALA424A, ALA8G, ARG11G, ARG235A, ARG242A, ARG244A, ARG436A, ARG438A, ARG9G, ASN435A, ASN6G, ASP245A, ASP246A, ASP332A, ASP417A, ASP433A, CYS419A, GLN159A, GLN23G, GLN430A, GLU22G, GLU240A, GLU429A, GLY238A, GLY426A, GLY5G, HIS12G, HIS3G, ILE13G, ILE14G, ILE241A, ILE2G, ILE331A, ILE428A, LEU18G, LEU248A, LEU329A, LEU422A, LEU431A, LEU432A, LEU7G, LYS418A, MET441A, PHE21G, PHE236A, PHE4G, PRO20G, PRO249A, PRO328A, PRO420A, PRO427A, SER17G, SER19G, SER239A, SER439A, THR156A, THR15G, THR237A, TYR152A, TYR16G, TYR434A, TYR442A, VAL10G, VAL425A
• A-I: ALA326A, ALA364A, ALA367A, ALA72I, ALA74I, ARG279A, ARG282A, ARG47I, ARG52I, ASN143A, ASN71I, ASP142A, ASP144A, ASP281A, ASP327A, CYS304A, CYS51I, GLN126A, GLN136A, GLN308A, GLN368A, GLU130A, GLU137A, GLU140A, GLU53I, GLY132A, GLY285A, GLY286A, GLY287A, GLY67I, HIS252A, HIS289A, HIS305A, HIS360A, HIS61A, ILE134A, ILE68I, LEU135A, LEU138A, LEU290A, LEU49I, LEU50I, LEU70I, LYS129A, LYS139A, LYS65A, MET141A, MET145A, MET365A, MET55I, PHE284A, PHE307A, PRO249A, PRO48I, PRO73I, SER291A, SER292A, SER306A, SER363A, SER54I, SER69I, SER75I, THR146A, THR283A, TYR280A, TYR57A, UNK28I, UNK29I, UNK30I, UNK31I, UNK32I, UNK33I, UNK34I, UNK35I, UNK36I, UNK37I, UNK38I, UNK42I, VAL133A, VAL250A, VAL325A
• A-J: ARG15J, ARG16J, ARG438A, ASP409A, ASP417A, CYS346A, CYS411A, CYS419A, ILE415A, ILE444A, LYS413A, LYS418A, PHE14J, SER18J, SER412A, THR17J, THR347A, TRP443A, TYR10J, TYR414A, TYR416A, TYR442A, VAL410A
• A-S: ARG104S, ARG293A, ARG49S, ASN108S, GLU100S, GLU351A, GLU353A, GLU45S, HIS289A, LYS109S, LYS110S, LYS288A, LYS355A, SER291A, SER352A, THR350A, TRP107S
• B-I: ALA149B, ALA151B, ALA255B, ALA256B, ALA269B, ALA281B, ALA300B, ALA302B, ALA309B, ALA311B, ALA60I, ALA66I, ALA72B, ALA72I, ALA74I, ALA91B, ARG102B, ARG287B, ARG46B, ARG52I, ARG58I, ARG61I, ARG62I, ARG70B, ARG77I, ARG87B, ASN162B, ASN313B, ASN315B, ASN380B, ASN71I, ASP147B, ASP180B, ASP308B, ASP63I, CYS108B, CYS51I, GLN143B, GLN153B, GLN156B, GLN276B, GLN297B, GLN305B, GLN329B, GLN376B, GLU103B, GLU110B, GLU161B, GLU381B, GLU53I, GLU90B, GLY158B, GLY280B, GLY282B, GLY288B, GLY320B, GLY323B, GLY377B, GLY57I, GLY67I, GLY88B, GLY93B, GLY94B, HIS164B, HIS250B, HIS254B, HIS277B, HIS67B, ILE285B, ILE327B, ILE68I, ILE85B, ILE89B, LEU140B, LEU144B, LEU160B, LEU163B, LEU176B, LEU252B, LEU284B, LEU295B, LEU321B, LEU364B, LEU49I, LEU50I, LEU64I, LEU68B, LEU69B, LEU70I, LEU71B, LEU96B, LYS104B, LYS145B, LYS286B, LYS301B, MET105B, MET55I, PHE152B, PHE307B, PHE312B, PHE322B, PHE324B, PRO155B, PRO175B, PRO283B, PRO306B, PRO48I, PRO73I, PRO74B, SER100B, SER154B, SER251B, SER273B, SER289B, SER290B, SER310B, SER328B, SER371B, SER54I, SER56I, SER59I, SER69I, SER73B, SER75I, SER82B, SER95B, SER97B, THR101B, THR106B, THR303B, THR304B, THR326B, THR367B, THR374B, THR86B, TYR107B, TYR122B, TYR177B, TYR296B, TYR316B, TYR325B, TYR368B, TYR99B, UNK28I, UNK29I, UNK33I, UNK34I, UNK35I, UNK36I, UNK37I, UNK38I, UNK39I, UNK40I, UNK41I, UNK42I, VAL109B, VAL119B, VAL126B, VAL146B, VAL150B, VAL157B, VAL159B, VAL253B, VAL258B, VAL264B, VAL299B, VAL314B, VAL336B, VAL65I, VAL76I, VAL98B
• B-O: ALA165B, ALA165O, ALA166B, ALA166O, ALA173B, ALA173O, ALA330B, ALA330O, ALA61B, ALA61O, ARG182B, ARG182O, ARG245B, ARG245O, ASN174B, ASN174O, ASN248B, ASN248O, ASP180B, ASP180O, ASP429B, ASP429O, ASP437B, ASP437O, GLN247B, GLN247O, GLU243B, GLU243O, GLU246B, GLU246O, GLU438B, GLU438O, GLY241B, GLY241O, GLY242B, GLY242O, GLY249B, GLY249O, GLY428B, GLY428O, GLY431B, GLY431O, HIS250B, HIS250O, ILE244B, ILE244O, LEU430B, LEU430O, LEU436B, LEU436O, LEU439B, LEU439O, LEU63B, LEU63O, LYS169B, LYS169O, LYS185B, LYS185O, LYS421B, LYS421O, MET424B, MET424O, PHE435B, PHE435O, PRO175B, PRO175O, PRO179B, PRO179O, PRO434B, PRO434O, SER432B, SER432O, THR170B, THR170O, THR238B, THR238O, THR433B, THR433O, THR59B, THR59O, THR60B, THR60O, TRP240B, TRP240O, TYR168B, TYR168O, TYR181B, TYR181O, TYR239B, TYR239O
• B-S: ALA106S, ALA46S, ALA80B, ALA91B, ARG104S, ARG133B, ARG49S, ARG84B, ARG87B, ARG99S, ASN108S, ASP139B, GLU100S, GLU103S, GLU105S, GLU131B, GLU136B, GLU45S, GLU90B, GLU96S, GLY79B, GLY88B, ILE85B, ILE89B, LEU50S, LYS109S, LYS110S, LYS48S, LYS78B, PHE83B, PRO134B, PRO51S, PRO92S, SER81B, SER82B, THR118B, THR138B, THR76B, THR86B, TRP107S, TRP135B, TYR122B, TYR93S, VAL92B, VAL97S
• B-V: LYS145B, UNK39V, UNK40V
• C-D: ALA119D, ALA193D, ALA194D, ALA213D, ALA244C, ALA24C, ALA30C, ALA47D, ALA68C, ARG102D, ARG120D, ARG191D, ARG201D, ARG203D, ARG224D, ARG233D, ARG49D, ARG72C, ARG81C, ASN118D, ASN249C, ASN256C, ASN261C, ASN27C, ASN33C, ASN50D, ASN73C, ASN82C, ASP112D, ASP199D, ASP217C, ASP229C, ASP253C, ASP44D, CYS71C, GLN138C, GLN200D, GLN75C, GLU195D, GLU197D, GLU255C, GLU2D, GLU345C, GLU4D, GLY122D, GLY123D, GLY15D, GLY16D, GLY205D, GLY232C, GLY252C, HIS121D, HIS198D, HIS222C, HIS225D, HIS268C, HIS69C, ILE116D, ILE211D, ILE219C, ILE230C, ILE28C, LEU109D, LEU113D, LEU18D, LEU190D, LEU206D, LEU209D, LEU210D, LEU215D, LEU218D, LEU219D, LEU230D, LEU231C, LEU233C, LEU235C, LEU237C, LEU241C, LEU243C, LEU245C, LEU263C, LEU62C, LEU79C, LEU83C, LYS202D, LYS207D, LYS218C, LYS223D, LYS226D, LYS228C, LYS231D, LYS270C, MET139C, MET204D, MET208D, MET222D, MET235D, MET236C, MET43D, PHE221C, PHE227C, PHE240C, PHE246C, PHE257C, PHE64C, PRO111D, PRO154D, PRO17D, PRO196D, PRO220C, PRO223C, PRO239C, PRO248C, PRO254C, PRO259C, PRO25C, PRO267C, PRO343C, PRO98D, SER114D, SER19D, SER212D, SER216C, SER217D, SER226C, SER228D, SER247C, SER26C, SER29C, SER65C, SER66C, THR216D, THR234C, THR238C, THR242C, THR258C, TRP192D, TRP227D, TRP78C, TYR115D, TYR220D, TYR221D, TYR224C, TYR225C, TYR45D, TYR76C, TYR90D, VAL117D, VAL229D, VAL264C, VAL46D, VAL67C
• C-E: ALA43E, ALA50E, ALA64E, ALA66E, ALA70E, ARG72C, ASN53E, ASN73C, ASP67E, GLN57E, GLN75C, GLY77C, HIS55C, HIS69C, HIS84C, ILE230C, ILE59E, ILE80C, LEU237C, LEU241C, LEU245C, LEU47C, LEU50C, LEU51C, LEU52C, LEU62E, LEU69E, LEU79C, LEU83C, MET54C, PHE227C, PHE58E, SER60E, SER61E, SER63E, SER65E, THR234C, THR40E, THR44C, THR47E, THR48C, THR56E, THR70C, TRP78C, TYR76C, VAL54E, VAL55E, VAL68E, VAL74C
• C-F: ALA23F, ALA24F, ALA30C, ALA65F, ARG15F, ARG17F, ARG314C, ARG319C, ARG33F, ARG58F, ARG61F, ARG64F, ARG73F, ASN207C, ASN208C, ASN22F, ASN27C, ASN27F, ASN375C, ASN379C, ASP215C, ASP217C, ASP34F, ASP35F, ASP40F, ASP67F, ASP86F, GLN313C, GLN323C, GLU374C, GLU39F, GLU91F, GLY106C, GLY211C, GLY25F, GLY371C, HIS309C, HIS72F, ILE16F, ILE212C, ILE219C, ILE28C, ILE370C, ILE62F, ILE74F, ILE98F, LEU109C, LEU210C, LEU31F, LEU321C, LEU373C, LEU378C, LEU37F, LEU47F, LEU66F, LEU68F, LEU70F, LEU90F, LEU94F, LYS111C, LYS18F, LYS218C, LYS228C, LYS28F, LYS312C, LYS376C, LYS44F, LYS63F, LYS71F, LYS87F, LYS95F, MET13F, MET316C, MET32F, MET377C, MET59F, PHE26F, PHE318C, PHE60F, PRO209C, PRO25C, PRO320C, PRO88F, PRO92F, SER213C, SER214C, SER216C, SER26C, SER29C, SER311C, SER322C, SER69F, THR315C, THR317C, THR324C, THR36F, TRP19F, TRP31C, TYR105C, TYR110C, TYR20F, TYR21F, TYR224C, TYR225C, TYR29F, TYR380C, TYR38F, TYR55F, TYR83F, TYR89F, VAL43F
• C-G: ALA24C, ALA30C, ALA331C, ALA355C, ALA49G, ALA55G, ALA8G, ARG319C, ARG40G, ARG68G, ARG9G, ASN16C, ASN17C, ASN332C, ASN6G, ASP215C, ASP217C, ASP21C, GLN323C, GLN342C, GLN44G, GLN64G, GLU203C, GLU345C, GLU65G, GLU67G, GLY205C, GLY352C, GLY54G, GLY5G, GLY62G, HIS202C, HIS222C, HIS268C, HIS346C, HIS3G, ILE13G, ILE20C, ILE219C, ILE2G, ILE335C, ILE339C, ILE349C, ILE350C, ILE351C, LEU201C, LEU22C, LEU321C, LEU325C, LEU328C, LEU329C, LEU333C, LEU334C, LEU53G, LEU57G, LEU58G, LEU69G, LEU7G, LYS13C, LYS218C, LYS47G, LYS70G, LYS7C, MET316C, MET354C, PHE221C, PHE318C, PHE326C, PHE348C, PHE46G, PHE4G, PHE52G, PHE66G, PRO20G, PRO220C, PRO223C, PRO23C, PRO320C, PRO343C, PRO347C, PRO50G, PRO51G, SER17G, SER204C, SER213C, SER214C, SER216C, SER29C, SER341C, SER43G, SER60G, THR15G, THR317C, THR324C, THR63G, TRP327C, TRP338C, TRP61G, TYR104C, TYR224C, TYR56G, TYR59G, VAL10G, VAL330C, VAL344C, VAL48G
• C-J: PHE246C, PHE43J
• C-P: ALA181C, ALA181P, ALA53C, ALA53P, ALA58C, ALA58P, ARG178C, ARG178P, ASN173C, ASN173P, ASP59C, ASP59P, GLU112C, GLU112P, GLU203C, GLU203P, GLY167C, GLY167P, GLY49C, GLY49P, HIS183C, HIS183P, HIS197C, HIS197P, HIS202C, HIS55C, HIS55P, HIS69C, HIS69P, HIS9C, HIS9P, ILE193C, ILE193P, ILE195C, ILE195P, ILE196C, ILE196P, ILE46C, ILE46P, LEU11C, LEU11P, LEU12C, LEU12P, LEU176C, LEU176P, LEU182C, LEU182P, LEU185C, LEU185P, LEU186C, LEU186P, LEU201C, LEU201P, LEU47C, LEU47P, LEU50C, LEU50P, LEU51C, LEU51P, LEU52C, LEU52P, LEU62C, LEU62P, LYS13C, LYS13P, MET14C, MET14P, MET54C, MET54P, PHE179C, PHE179P, PHE180C, PHE180P, PHE184C, PHE184P, PHE188C, PHE188P, PHE200C, PHE200P, PRO10C, PRO10P, PRO174C, PRO174P, PRO187C, PRO187P, SER61C, SER61P, SER66C, SER66P, SER8C, SER8P, THR116C, THR116P, THR175C, THR175P, THR177C, THR177P, THR199C, THR199P, THR57C, THR57P, THR60C, THR60P, TRP164C, TRP164P, TYR56C, TYR56P, VAL74C, VAL74P
• C-R: ALA165C, ALA181C, ALA64R, ALA70R, ARG178C, ARG92R, ASN173C, ASN261C, ASP172C, ASP67R, CYS139R, CYS144R, CYS160R, GLN138C, GLU163C, GLY137R, GLY143R, GLY167C, GLY168C, GLY93R, HIS141R, HIS161R, HIS268C, ILE269C, ILE59R, LEU142R, LEU182C, LEU263C, LEU62R, LEU69R, LEU71R, LYS73R, LYS90R, LYS94R, PHE141C, PHE169C, PHE58R, PRO146R, PRO174C, PRO262C, PRO266C, PRO267C, PRO95R, SER170C, SER60R, SER61R, SER63R, SER65R, SER72R, THR140R, THR145C, THR160C, THR175C, THR265C, TRP142C, TRP164C, TRP166C, TRP91R, VAL136R, VAL138R, VAL145R, VAL171C, VAL264C, VAL55R, VAL68R
• D-E: ALA12E, ALA236D, ALA41E, ALA43E, ALA46E, ALA47D, ALA48E, ALA50E, ALA51E, ALA66E, ALA70E, ARG14E, ARG15E, ARG224D, ARG233D, ARG238D, ARG32E, ARG49D, ARG83D, ASN3E, ASN50D, ASN53E, ASP4E, ASP67E, ASP72D, ASP89D, ASP9E, CYS44E, GLN200D, GLN57E, GLU58D, GLU75E, GLY73D, HIS225D, HIS2E, ILE211D, ILE74E, ILE87D, LEU192E, LEU210D, LEU214D, LEU215D, LEU218D, LEU219D, LEU38E, LEU69E, LEU71E, LYS207D, LYS223D, LYS226D, LYS231D, LYS234D, LYS33E, LYS62D, LYS73E, LYS77E, LYS86D, LYS90E, MET204D, MET208D, MET222D, MET235D, PHE10E, PHE35E, PHE58E, PHE89E, PRO239D, PRO240D, PRO74D, PRO8E, SER11E, SER212D, SER217D, SER228D, SER232D, SER36E, SER65E, SER72E, SER88D, THR216D, THR40E, THR42E, THR47E, THR6E, TYR13E, TYR220D, TYR221D, TYR37E, TYR49E, TYR90D, VAL1E, VAL229D, VAL39E, VAL45E, VAL54E, VAL5E, VAL68E, VAL7E
• D-F: ALA236D, ALA65F, ARG224D, ARG233D, ARG238D, ARG58F, ARG61F, ARG64F, ARG73F, ASN56F, ASP53F, ASP67F, GLU52F, GLU57F, HIS72F, ILE62F, LEU230D, LEU54F, LEU66F, LEU68F, LEU70F, LYS223D, LYS231D, LYS234D, LYS241D, LYS63F, LYS71F, LYS87F, MET235D, MET59F, PHE60F, PRO239D, PRO240D, SER228D, SER232D, SER69F, TRP227D, TYR237D, TYR55F, VAL229D
• D-G: ALA139D, ALA236D, ALA25G, ALA33G, ARG11G, ARG224D, ARG233D, ARG238D, ARG24G, ARG40G, ARG71G, ASN28G, GLN23G, GLU22G, GLU2D, GLU4D, GLU67G, GLY1D, HIS12G, HIS225D, HIS6D, ILE13G, ILE14G, ILE26G, ILE29G, LEU18G, LEU230D, LEU3D, LEU69G, LYS223D, LYS226D, LYS231D, LYS234D, LYS241D, LYS70G, LYS72G, MET222D, MET235D, PHE21G, PHE66G, PRO138D, PRO20G, PRO239D, PRO240D, PRO27G, SER17G, SER19G, SER217D, SER228D, SER232D, THR15G, TRP227D, TYR16G, TYR220D, TYR221D, TYR237D, VAL10G, VAL229D
• D-H: ALA139D, ALA177D, ALA183D, ALA42H, ALA64H, ALA70H, ALA9D, ARG21H, ARG28D, ARG43H, ARG47H, ARG65H, ASN150D, ASN166D, ASN75H, ASP125D, ASP136D, ASP15H, ASP173D, ASP185D, ASP22D, ASP41H, ASP60H, ASP66H, CYS135D, CYS187D, CYS40H, CYS54H, CYS68H, GLN156D, GLN181D, GLN53H, GLU124D, GLU12H, GLU167D, GLU170D, GLU2D, GLU4D, GLU51H, GLU52H, GLU56H, GLU57H, GLY133D, GLY140D, GLY155D, GLY174D, GLY1D, HIS14D, HIS63H, HIS67H, HIS6D, HIS71H, ILE168D, ILE182D, ILE20H, LEU131D, LEU13H, LEU169D, LEU17H, LEU37H, LEU3D, LEU58H, LEU5D, LEU62H, LEU73H, LEU77H, LYS184D, LYS72H, LYS76H, LYS78H, MET179D, PHE10D, PHE128D, PHE153D, PHE59H, PHE61H, PHE74H, PRO11D, PRO137D, PRO138D, PRO151D, PRO154D, PRO16H, PRO176D, PRO7D, PRO8D, SER129D, SER13D, SER180D, SER24D, SER25D, SER45H, SER46H, THR132D, THR175D, THR178D, THR188D, THR18H, THR50H, THR55H, TRP12D, TYR134D, TYR149D, TYR152D, TYR165D, TYR171D, VAL141D, VAL142D, VAL14H, VAL44H, VAL69H
• D-J: ALA20D, ALA213D, ALA39J, ALA41J, ALA59D, ALA61J, ALA63D, ARG201D, ARG203D, ARG27D, ARG28D, ASN47J, ASP172D, ASP173D, ASP199D, ASP22D, ASP36J, ASP40J, GLN200D, GLN31D, GLN37J, GLU32J, GLU44J, GLU48J, GLU58D, GLU60D, GLU60J, GLU63J, GLU64J, GLY15D, GLY16D, GLY205D, GLY38J, GLY49J, GLY53D, HIS14D, HIS198D, HIS23D, HIS45J, HIS54J, HIS56D, ILE211D, ILE42J, ILE52D, ILE55J, LEU18D, LEU206D, LEU209D, LEU210D, LEU214D, LEU215D, LEU218D, LEU21D, LEU46J, LEU51D, LEU51J, LYS184D, LYS202D, LYS207D, LYS50J, LYS53J, LYS56J, LYS58J, MET204D, MET208D, MET222D, PHE20J, PHE31J, PHE35J, PHE43J, PRO17D, SER13D, SER19D, SER212D, SER24D, SER25D, SER62J, THR55D, THR57D, TRP12D, TRP52J, TYR59J, VAL26D, VAL54D
• D-Q: ALA100D, ALA100Q, ALA101D, ALA101Q, ALA103D, ALA103Q, ALA104D, ALA104Q, ARG102D, ARG102Q, ASN77D, ASN77Q, ASN97D, ASN97Q, ASP75D, ASP75Q, GLU76D, GLU76Q, GLU79D, GLU79Q, GLU99D, GLU99Q, GLY107D, GLY107Q, GLY73D, GLY73Q, GLY78D, GLY78Q, LEU80D, LEU80Q, PHE81D, PRO74D, PRO74Q, PRO96D, PRO96Q, PRO98D, PRO98Q, TYR95D, TYR95Q
• D-R: ARG102D, ARG144D, ASN106D, CYS144R, CYS158R, CYS160R, GLY107D, GLY155D, GLY162R, HIS161R, ILE147R, LEU147D, PHE153D, PRO154D, PRO159R, TYR157R, VAL145R
• E-F: ARG73F, LYS71F, PHE10E, TYR13E
• E-G: ALA12E, ALA25G, ARG14E, ARG15E, ARG24G, ARG32E, ASN28G, ASP17E, ASP31E, ASP32G, ASP9E, GLN23G, GLN26E, GLU16E, GLU22G, GLY34E, HIS2E, ILE14G, ILE26G, LEU18G, LEU38E, LYS33E, MET19E, PHE10E, PHE21G, PHE35E, PRO20G, PRO27G, PRO8E, SER11E, SER17G, SER19G, SER25E, SER28E, SER29E, SER31G, SER36E, THR15G, THR40E, THR6E, TYR13E, TYR16G, TYR37E, VAL18E, VAL5E, VAL7E
• E-J: ALA21J, ALA28J, ALA39J, ALA41E, ALA43E, ALA46E, ALA48E, ALA4J, ALA50E, ALA9J, ARG15E, ARG15J, ARG32E, ARG33J, ARG7J, ASN53E, ASP17E, ASP31E, ASP36J, ASP40J, CYS44E, GLN26E, GLN37J, GLN8J, GLU30E, GLU32J, GLY27J, GLY34E, LEU13J, LEU22J, LEU26J, LEU30J, LEU38E, LEU5J, LEU6J, LYS33E, LYS52E, PHE14J, PHE20J, PHE31J, PHE35E, PHE35J, SER11J, SER28E, SER29E, SER36E, THR23J, THR27E, THR40E, THR42E, THR47E, THR56E, TYR10J, TYR37E, TYR49E, VAL24J, VAL25J, VAL29J, VAL39E, VAL45E
• E-P: ALA165P, ALA181P, ALA64E, ALA70E, ARG178P, ARG92E, ASN173P, ASN261P, ASP172P, ASP67E, CYS139E, CYS144E, CYS160E, GLN138P, GLU163P, GLU181E, GLY137E, GLY143E, GLY167P, GLY168P, GLY196E, GLY93E, HIS141E, HIS159P, HIS161E, HIS268P, ILE269P, ILE59E, LEU142E, LEU182P, LEU263P, LEU62E, LEU69E, LEU71E, LYS288P, LYS73E, LYS90E, LYS94E, PHE141P, PHE169P, PHE58E, PRO174P, PRO262P, PRO266P, PRO267P, PRO95E, SER170P, SER60E, SER61E, SER63E, SER65E, SER72E, THR140E, THR145P, THR160P, THR175P, THR177P, THR265P, TRP142P, TRP164P, TRP166P, TRP91E, TYR178E, VAL138E, VAL145E, VAL171P, VAL264P, VAL68E
• E-Q: ARG102Q, ARG144Q, CYS144E, CYS160E, GLU2Q, GLY155Q, GLY1Q, HIS141E, HIS161E, LEU147Q, PRO154Q, PRO159E, PRO175E, TYR157E
• E-U: GLU51U, LYS173E
• F-G: ALA23F, ALA24F, ALA33G, ALA8G, ARG11G, ARG39G, ARG40G, ARG58F, ARG61F, ARG64F, ARG73F, ARG9G, ASN22F, ASN28G, ASN36G, ASN56F, ASP32G, ASP53F, ASP67F, GLU52F, GLU57F, GLY25F, HIS12G, HIS72F, ILE13G, ILE14G, ILE29G, ILE62F, ILE74F, LEU34G, LEU68F, LEU75F, LEU7G, LYS28F, LYS47G, LYS63F, LYS71F, MET59F, PHE60F, PRO27G, PRO35G, SER17G, SER31G, SER43G, SER69F, THR15G, TRP19F, TRP38G, TRP80F, TYR16G, TYR29F, TYR55F, VAL10G, VAL37G
• F-N: ARG104F, ARG293N, ARG356N, ARG49F, ASN108F, GLU100F, GLU351N, GLU353N, GLU45F, HIS289N, LYS109F, LYS110F, LYS288N, SER291N, SER352N, THR350N, TRP107F
• F-O: ALA106F, ALA46F, ALA80O, ALA91O, ARG104F, ARG133O, ARG49F, ARG84O, ARG87O, ARG99F, ASN108F, ASP139O, GLU100F, GLU103F, GLU105F, GLU131O, GLU136O, GLU45F, GLU90O, GLU96F, GLY79O, GLY88O, ILE85O, ILE89O, LEU102F, LEU50F, LYS109F, LYS110F, LYS48F, PHE83O, PRO134O, PRO51F, PRO92F, SER81O, SER82O, THR118O, THR138O, THR76O, THR86O, TRP107F, TRP135O, TYR122O, TYR93F, VAL92O, VAL97F
• G-H: ARG36H, ARG43H, ARG47H, ARG71G, ASN73G, ASN79G, ASP41H, ASP60H, ASP76G, ASP80G, CYS40H, CYS54H, GLN53H, GLN81G, GLU51H, GLU52H, GLU56H, GLU57H, GLU78G, HIS49H, LEU37H, LEU58H, LYS70G, LYS72G, PHE59H, PRO74G, SER46H, SER48H, THR50H, THR55H, TYR77G, VAL44H
• G-J: PHE21G, TYR10J
• H-J: LYS58J, LYS78H
• I-O: ASP180O, LYS145O, LYS185O, UNK38I, UNK39I, UNK40I, UNK41I, UNK42I
• I-V: UNK38I, UNK39I, UNK39V, UNK40I, UNK40V, UNK41I
• N-O: ALA101N, ALA149O, ALA151O, ALA21O, ALA281O, ALA295N, ALA296N, ALA357N, ALA360O, ALA364N, ALA366O, ALA367N, ALA375O, ALA44O, ALA5N, ALA63N, ALA72O, ALA73N, ALA74N, ALA84N, ALA91O, ALA96N, ARG113O, ARG279N, ARG282N, ARG287O, ARG293N, ARG356N, ARG362N, ARG46O, ARG70O, ARG84O, ARG87O, ASN10N, ASN359N, ASN362O, ASN40O, ASN87N, ASP105N, ASP114O, ASP139O, ASP147O, ASP281N, ASP356O, ASP370N, ASP396N, CYS111O, CYS18O, CYS35N, CYS72N, GLN126N, GLN136N, GLN143O, GLN153O, GLN297O, GLN32N, GLN363O, GLN376O, GLN6N, GLN9N, GLU110O, GLU130N, GLU136O, GLU137N, GLU140N, GLU168N, GLU355O, GLU373O, GLU39O, GLU60N, GLU76N, GLU78N, GLU80N, GLU90O, GLY201N, GLY20O, GLY210O, GLY282O, GLY285N, GLY286N, GLY287N, GLY288O, GLY371N, GLY377O, GLY66N, GLY83N, GLY88N, GLY88O, GLY93O, GLY94O, HIS115O, HIS277O, HIS289N, HIS305N, HIS360N, HIS61N, HIS85N, ILE11N, ILE134N, ILE285O, ILE399N, ILE85O, ILE89O, ILE99N, LEU102N, LEU112N, LEU112O, LEU140O, LEU252O, LEU284O, LEU290N, LEU361N, LEU364O, LEU369N, LEU369O, LEU378O, LEU392N, LEU62N, LEU71O, LEU75O, LEU8N, LEU96O, LYS100N, LYS104N, LYS129N, LYS145O, LYS148O, LYS286O, LYS288N, LYS302N, LYS355N, LYS358N, LYS359O, LYS361O, LYS365O, LYS65N, LYS77N, MET141N, MET365N, MET370O, MET82N, PHE284N, PHE41O, PHE58N, PHE64N, PHE75N, PHE83O, PHE86N, PHE97N, PRO12N, PRO142O, PRO19O, PRO283O, PRO306O, PRO33N, PRO374N, PRO395O, PRO43O, PRO74O, SER103N, SER289O, SER290O, SER291N, SER292N, SER293O, SER31N, SER352N, SER363N, SER371O, SER42O, SER45O, SER73O, SER81N, SER81O, SER82O, SER95O, SER97O, THR283N, THR292O, THR304O, THR34N, THR358O, THR367O, THR36N, THR372N, THR373N, THR374O, THR3N, THR76O, THR7N, THR86O, THR90N, TRP135O, TYR280N, TYR368O, TYR4N, TYR57N, TYR89N, TYR98N, VAL133N, VAL146O, VAL150O, VAL167N, VAL291O, VAL299N, VAL366N, VAL372O, VAL375N, VAL59N, VAL79N, VAL92O
• N-P: ALA24P, ALA2P, ARG242N, ARG244N, ARG436N, ARG438N, ARG6P, ASN16P, ASN435N, ASN4P, ASP215P, ASP217P, ASP21P, ASP246N, ASP332N, ASP333N, ASP433N, CYS337N, GLN430N, GLU300N, GLU429N, HIS222P, HIS301N, ILE20P, ILE219P, ILE331N, ILE437N, ILE5P, LEU19P, LEU22P, LEU297N, LEU303N, LEU329N, LEU432N, LYS218P, LYS7P, MET334N, PHE221P, PHE336N, PRO220P, PRO223P, PRO23P, PRO3P, SER216P, SER26P, SER330N, SER439N, TYR224P, TYR434N, TYR442N
• N-Q: ALA236Q, ALA243N, ARG233Q, ARG238Q, ARG242N, ARG244N, ARG436N, ARG438N, ASN435N, ASP245N, ASP433N, CYS419N, GLU240N, HIS225Q, ILE241N, LEU230Q, LEU432N, LYS223Q, LYS226Q, LYS231Q, LYS234Q, MET235Q, PRO240Q, SER228Q, SER239N, SER439N, THR170N, THR171N, TRP227Q, TYR152N, TYR434N, TYR442N, VAL229Q
• N-R: ALA155N, ALA157N, ALA162N, ALA164N, ALA21R, ALA243N, ARG14R, ARG15R, ARG165N, ARG233N, ARG235N, ARG32R, ARG438N, ARG46N, ARG92N, ASN143N, ASN147N, ASN173N, ASN3R, ASN53N, ASP142N, ASP144N, ASP151N, ASP17R, ASP20R, ASP316N, ASP417N, ASP4R, ASP9R, CYS234N, CYS419N, GLN136N, GLN159N, GLN26R, GLU137N, GLU140N, GLU168N, GLU172N, GLU240N, GLU258N, GLU30R, GLU50N, GLY160N, GLY169N, GLY238N, GLY259N, HIS154N, HIS2R, ILE134N, ILE174N, ILE241N, ILE415N, LEU135N, LEU138N, LEU153N, LEU231N, LYS139N, LYS33R, LYS413N, LYS418N, MET141N, MET145N, MET19R, MET441N, PHE10R, PHE150N, PHE158N, PHE236N, PRO232N, PRO260N, PRO420N, PRO8R, SER11R, SER239N, SER24R, SER25R, SER28R, SER29R, SER36R, SER439N, THR149N, THR156N, THR161N, THR166N, THR170N, THR171N, THR22R, THR237N, THR23R, THR27R, THR317N, THR6R, TYR152N, TYR37R, TYR414N, TYR416N, TYR442N, VAL148N, VAL167N, VAL18R, VAL1R, VAL257N, VAL425N, VAL5R, VAL7R
• N-S: ALA247N, ARG242N, ARG244N, ASN56S, ASP245N, ASP246N, GLU52S, LEU432N, LYS63S, MET59S, TYR55S
• N-T: ALA155N, ALA243N, ALA247N, ALA421N, ALA424N, ALA8T, ARG11T, ARG235N, ARG242N, ARG244N, ARG436N, ARG438N, ARG9T, ASN435N, ASN6T, ASP245N, ASP246N, ASP332N, ASP417N, ASP433N, CYS419N, GLN159N, GLN23T, GLN430N, GLU22T, GLU240N, GLU429N, GLY238N, GLY426N, GLY5T, HIS12T, HIS3T, ILE13T, ILE14T, ILE241N, ILE2T, ILE331N, ILE428N, LEU18T, LEU248N, LEU329N, LEU422N, LEU431N, LEU432N, LEU7T, LYS418N, MET441N, PHE21T, PHE236N, PHE4T, PRO20T, PRO249N, PRO328N, PRO420N, PRO427N, SER17T, SER19T, SER239N, SER439N, THR156N, THR15T, THR237N, TYR152N, TYR16T, TYR434N, TYR442N, VAL10T, VAL425N
• N-V: ALA326N, ALA364N, ALA367N, ALA72V, ALA74V, ARG279N, ARG282N, ARG362N, ARG47V, ARG52V, ASN143N, ASN359N, ASN71V, ASP142N, ASP144N, ASP281N, ASP327N, CYS304N, CYS51V, GLN136N, GLN308N, GLN368N, GLU130N, GLU137N, GLU140N, GLU53V, GLY132N, GLY285N, GLY286N, GLY287N, GLY67V, HIS252N, HIS289N, HIS305N, HIS323N, HIS360N, HIS61N, ILE134N, ILE68V, LEU135N, LEU138N, LEU290N, LEU361N, LEU49V, LEU50V, LEU70V, LYS129N, LYS139N, LYS65N, MET141N, MET145N, MET365N, MET55V, PHE284N, PHE307N, PRO249N, PRO48V, PRO73V, SER291N, SER306N, SER363N, SER54V, SER69V, SER75V, THR146N, THR283N, TYR280N, UNK28V, UNK29V, UNK30V, UNK31V, UNK32V, UNK33V, UNK35V, UNK36V, UNK37V, UNK38V, UNK39V, VAL133N, VAL250N, VAL325N, VAL366N
• N-W: ARG15W, ARG16W, ARG438N, ASP409N, ASP417N, CYS346N, CYS411N, ILE415N, ILE444N, LYS413N, LYS418N, MET343N, PHE14W, SER18W, SER412N, THR17W, THR347N, TRP443N, TYR10W, TYR414N, TYR416N, TYR442N, VAL410N
• O-V: ALA149O, ALA151O, ALA255O, ALA256O, ALA269O, ALA281O, ALA300O, ALA309O, ALA311O, ALA60V, ALA66V, ALA72O, ALA72V, ALA74V, ALA91O, ARG102O, ARG287O, ARG46O, ARG52V, ARG58V, ARG61V, ARG62V, ARG70O, ARG77V, ARG87O, ASN162O, ASN270O, ASN313O, ASN315O, ASN380O, ASN71V, ASP147O, ASP180O, ASP308O, ASP63V, CYS108O, CYS111O, CYS51V, GLN143O, GLN153O, GLN156O, GLN276O, GLN305O, GLN329O, GLN376O, GLU103O, GLU110O, GLU161O, GLU53V, GLU90O, GLY158O, GLY280O, GLY282O, GLY288O, GLY320O, GLY323O, GLY377O, GLY57V, GLY67V, GLY88O, GLY93O, GLY94O, HIS164O, HIS250O, HIS254O, HIS277O, HIS67O, ILE285O, ILE327O, ILE68V, ILE85O, ILE89O, LEU140O, LEU144O, LEU160O, LEU163O, LEU176O, LEU252O, LEU284O, LEU295O, LEU321O, LEU364O, LEU49V, LEU50V, LEU64V, LEU68O, LEU69O, LEU70V, LEU71O, LEU96O, LYS104O, LYS145O, LYS286O, LYS301O, MET105O, MET55V, PHE152O, PHE307O, PHE312O, PHE322O, PHE324O, PRO155O, PRO175O, PRO283O, PRO306O, PRO48V, PRO73V, PRO74O, SER100O, SER154O, SER251O, SER273O, SER289O, SER290O, SER310O, SER328O, SER371O, SER54V, SER56V, SER59V, SER69V, SER73O, SER75V, SER82O, SER95O, SER97O, THR101O, THR106O, THR303O, THR304O, THR326O, THR367O, THR374O, THR86O, TYR107O, TYR122O, TYR177O, TYR296O, TYR316O, TYR325O, TYR368O, TYR99O, UNK28V, UNK29V, UNK30V, UNK32V, UNK33V, UNK35V, UNK36V, UNK37V, UNK38V, UNK39V, UNK40V, VAL109O, VAL119O, VAL126O, VAL146O, VAL150O, VAL157O, VAL159O, VAL253O, VAL258O, VAL264O, VAL299O, VAL314O, VAL336O, VAL65V, VAL76V, VAL98O
• P-Q: ALA119Q, ALA193Q, ALA194Q, ALA213Q, ALA244P, ALA24P, ALA30P, ALA47Q, ALA63P, ALA68P, ARG102Q, ARG120Q, ARG191Q, ARG201Q, ARG203Q, ARG224Q, ARG233Q, ARG49Q, ARG72P, ARG81P, ASN118Q, ASN249P, ASN256P, ASN261P, ASN27P, ASN33P, ASN50Q, ASN73P, ASN82P, ASP112Q, ASP217P, ASP229P, ASP253P, ASP44Q, CYS71P, GLN138P, GLN200Q, GLN75P, GLU195Q, GLU197Q, GLU255P, GLU2Q, GLU345P, GLU4Q, GLY122Q, GLY123Q, GLY15Q, GLY16Q, GLY205Q, GLY232P, GLY252P, HIS121Q, HIS198Q, HIS222P, HIS225Q, HIS268P, HIS69P, ILE116Q, ILE211Q, ILE219P, ILE230P, ILE28P, LEU109Q, LEU113Q, LEU18Q, LEU190Q, LEU206Q, LEU209Q, LEU210Q, LEU215Q, LEU218Q, LEU219Q, LEU230Q, LEU231P, LEU233P, LEU235P, LEU237P, LEU241P, LEU243P, LEU245P, LEU263P, LEU62P, LEU79P, LEU83P, LYS202Q, LYS207Q, LYS218P, LYS223Q, LYS226Q, LYS228P, LYS231Q, LYS270P, MET139P, MET204Q, MET208Q, MET222Q, MET235Q, MET236P, MET43Q, PHE221P, PHE227P, PHE240P, PHE246P, PHE257P, PHE64P, PRO111Q, PRO154Q, PRO17Q, PRO196Q, PRO220P, PRO223P, PRO239P, PRO248P, PRO254P, PRO259P, PRO25P, PRO267P, PRO98Q, SER114Q, SER19Q, SER212Q, SER216P, SER217Q, SER226P, SER228Q, SER247P, SER26P, SER29P, SER65P, SER66P, THR216Q, THR234P, THR238P, THR242P, THR258P, TRP192Q, TRP227Q, TRP78P, TYR115Q, TYR220Q, TYR221Q, TYR224P, TYR225P, TYR45Q, TYR76P, TYR90Q, VAL117Q, VAL229Q, VAL264P, VAL46Q, VAL67P
• P-R: ALA43R, ALA50R, ALA64R, ALA66R, ALA70R, ARG72P, ASN53R, ASN73P, ASP67R, GLN57R, GLN75P, GLY77P, HIS55P, HIS69P, HIS84P, ILE230P, ILE59R, ILE80P, LEU237P, LEU241P, LEU245P, LEU47P, LEU50P, LEU51P, LEU52P, LEU62R, LEU69R, LEU79P, LEU83P, MET54P, PHE227P, PHE58R, SER60R, SER61R, SER63R, SER65R, THR234P, THR40R, THR44P, THR47R, THR48P, THR56R, THR70P, TRP78P, TYR76P, VAL54R, VAL55R, VAL68R, VAL74P
• P-S: ALA23S, ALA24S, ALA30P, ALA65S, ARG15S, ARG17S, ARG314P, ARG319P, ARG33S, ARG58S, ARG61S, ARG64S, ARG73S, ASN207P, ASN208P, ASN22S, ASN27P, ASN27S, ASN375P, ASN379P, ASP14S, ASP215P, ASP217P, ASP34S, ASP35S, ASP40S, ASP42S, ASP67S, GLN313P, GLN323P, GLU374P, GLU39S, GLU91S, GLY106P, GLY211P, GLY25S, GLY371P, HIS309P, HIS72S, ILE16S, ILE212P, ILE219P, ILE28P, ILE370P, ILE62S, ILE74S, ILE98S, LEU109P, LEU210P, LEU31S, LEU321P, LEU373P, LEU378P, LEU37S, LEU47S, LEU66S, LEU68S, LEU70S, LEU90S, LEU94S, LYS111P, LYS18S, LYS218P, LYS228P, LYS28S, LYS312P, LYS376P, LYS44S, LYS63S, LYS71S, LYS95S, MET13S, MET316P, MET32S, MET377P, MET59S, PHE26S, PHE318P, PHE60S, PRO209P, PRO25P, PRO320P, PRO88S, PRO92S, SER213P, SER214P, SER216P, SER26P, SER29P, SER311P, SER322P, SER69S, THR315P, THR317P, THR36S, TRP19S, TRP31P, TYR105P, TYR108P, TYR110P, TYR20S, TYR21S, TYR224P, TYR225P, TYR29S, TYR380P, TYR38S, TYR55S, TYR83S, TYR89S, VAL43S
• P-T: ALA24P, ALA30P, ALA331P, ALA355P, ALA49T, ALA55T, ALA8T, ARG319P, ARG40T, ARG68T, ARG9T, ASN16P, ASN17P, ASN332P, ASN6T, ASP215P, ASP217P, ASP21P, GLN323P, GLN342P, GLN44T, GLN64T, GLU203P, GLU345P, GLU65T, GLU67T, GLY205P, GLY352P, GLY54T, GLY5T, GLY62T, HIS202P, HIS222P, HIS268P, HIS346P, HIS3T, ILE13T, ILE20P, ILE219P, ILE2T, ILE335P, ILE339P, ILE349P, ILE350P, ILE351P, LEU201P, LEU22P, LEU321P, LEU325P, LEU328P, LEU329P, LEU333P, LEU334P, LEU336P, LEU53T, LEU57T, LEU58T, LEU69T, LEU7T, LYS13P, LYS218P, LYS47T, LYS70T, LYS7P, MET316P, MET354P, PHE221P, PHE318P, PHE326P, PHE348P, PHE46T, PHE4T, PHE52T, PHE66T, PRO20T, PRO220P, PRO223P, PRO23P, PRO320P, PRO343P, PRO347P, PRO50T, PRO51T, SER204P, SER213P, SER214P, SER216P, SER29P, SER341P, SER43T, SER60T, THR15T, THR317P, THR324P, THR63T, TRP327P, TRP338P, TRP61T, TYR104P, TYR105P, TYR224P, TYR56T, TYR59T, VAL10T, VAL330P, VAL344P, VAL48T
• P-W: PHE246P, PHE43W
• Q-R: ALA12R, ALA236Q, ALA41R, ALA43R, ALA46R, ALA47Q, ALA48R, ALA50R, ALA51R, ALA66R, ALA70R, ARG14R, ARG15R, ARG224Q, ARG233Q, ARG238Q, ARG32R, ARG49Q, ARG83Q, ASN3R, ASN50Q, ASN53R, ASP4R, ASP67R, ASP72Q, ASP89Q, ASP9R, CYS44R, GLN200Q, GLN57R, GLU58Q, GLU66Q, GLU75R, GLY34R, GLY73Q, HIS225Q, HIS2R, ILE211Q, ILE74R, ILE76R, ILE87Q, LEU192R, LEU210Q, LEU214Q, LEU215Q, LEU218Q, LEU219Q, LEU38R, LEU69R, LEU71R, LYS207Q, LYS223Q, LYS226Q, LYS231Q, LYS234Q, LYS33R, LYS62Q, LYS73R, LYS77R, LYS86Q, LYS90R, MET204Q, MET208Q, MET222Q, MET235Q, PHE10R, PHE35R, PHE58R, PHE89R, PRO239Q, PRO240Q, PRO8R, SER11R, SER212Q, SER217Q, SER228Q, SER232Q, SER36R, SER65R, SER88Q, THR216Q, THR40R, THR42R, THR47R, THR6R, TRP91R, TYR13R, TYR220Q, TYR221Q, TYR37R, TYR49R, TYR90Q, VAL1R, VAL229Q, VAL39R, VAL45R, VAL54R, VAL5R, VAL68R, VAL7R
• Q-S: ALA236Q, ALA65S, ARG224Q, ARG233Q, ARG238Q, ARG58S, ARG61S, ARG64S, ARG73S, ASN56S, ASP53S, ASP67S, GLU52S, GLU57S, HIS72S, ILE62S, LEU230Q, LEU54S, LEU66S, LEU68S, LEU70S, LYS223Q, LYS231Q, LYS234Q, LYS241Q, LYS63S, LYS71S, MET235Q, MET59S, PHE60S, PRO239Q, PRO240Q, SER228Q, SER232Q, SER69S, TRP227Q, TYR237Q, TYR55S, VAL229Q
• Q-T: ALA139Q, ALA236Q, ALA25T, ALA33T, ARG11T, ARG224Q, ARG233Q, ARG238Q, ARG24T, ARG40T, ARG71T, ASN28T, GLN23T, GLU22T, GLU2Q, GLU4Q, GLU67T, HIS12T, HIS225Q, HIS6Q, ILE13T, ILE14T, ILE26T, ILE29T, LEU18T, LEU230Q, LEU3Q, LEU69T, LYS223Q, LYS226Q, LYS231Q, LYS234Q, LYS241Q, LYS70T, LYS72T, MET222Q, MET235Q, PHE21T, PHE66T, PRO138Q, PRO20T, PRO239Q, PRO240Q, PRO27T, SER17T, SER19T, SER217Q, SER228Q, SER232Q, THR15T, TRP227Q, TYR16T, TYR220Q, TYR221Q, TYR237Q, VAL10T, VAL229Q
• Q-U: ALA139Q, ALA177Q, ALA183Q, ALA42U, ALA64U, ALA70U, ALA9Q, ARG21U, ARG28Q, ARG43U, ARG65U, ASN150Q, ASN166Q, ASN75U, ASP125Q, ASP136Q, ASP15U, ASP173Q, ASP185Q, ASP22Q, ASP41U, ASP60U, ASP66U, CYS135Q, CYS187Q, CYS40U, CYS54U, CYS68U, GLN156Q, GLN181Q, GLN53U, GLU124Q, GLU12U, GLU167Q, GLU170Q, GLU2Q, GLU38U, GLU4Q, GLU51U, GLU52U, GLU56U, GLU57U, GLY133Q, GLY140Q, GLY155Q, GLY174Q, GLY1Q, HIS14Q, HIS63U, HIS67U, HIS6Q, HIS71U, ILE168Q, ILE182Q, ILE20U, LEU131Q, LEU13U, LEU169Q, LEU17U, LEU37U, LEU39U, LEU3Q, LEU58U, LEU5Q, LEU62U, LEU73U, LEU77U, LYS184Q, LYS72U, LYS76U, LYS78U, MET179Q, PHE10Q, PHE128Q, PHE153Q, PHE59U, PHE61U, PHE74U, PRO11Q, PRO137Q, PRO138Q, PRO151Q, PRO154Q, PRO16U, PRO176Q, PRO7Q, PRO8Q, SER129Q, SER13Q, SER180Q, SER24Q, SER25Q, SER45U, SER46U, THR132Q, THR175Q, THR178Q, THR188Q, THR18U, THR19U, THR50U, THR55U, TRP12Q, TYR134Q, TYR149Q, TYR152Q, TYR165Q, TYR171Q, VAL141Q, VAL142Q, VAL14U, VAL44U, VAL69U
• Q-W: ALA20Q, ALA213Q, ALA39W, ALA41W, ALA59Q, ALA61W, ARG201Q, ARG203Q, ARG27Q, ARG28Q, ASN47W, ASP172Q, ASP173Q, ASP199Q, ASP22Q, ASP36W, ASP40W, GLN200Q, GLN31Q, GLN37W, GLU32W, GLU44W, GLU48W, GLU58Q, GLU60Q, GLU60W, GLY15Q, GLY16Q, GLY205Q, GLY38W, GLY49W, GLY53Q, HIS14Q, HIS198Q, HIS23Q, HIS45W, HIS54W, HIS56Q, ILE211Q, ILE42W, ILE52Q, ILE55W, LEU18Q, LEU206Q, LEU209Q, LEU210Q, LEU214Q, LEU215Q, LEU218Q, LEU21Q, LEU46W, LEU51Q, LEU51W, LYS202Q, LYS207Q, LYS50W, LYS53W, LYS56W, LYS58W, MET204Q, MET208Q, MET222Q, PHE20W, PHE31W, PHE35W, PHE43W, PRO17Q, SER13Q, SER19Q, SER212Q, SER24Q, SER25Q, SER62W, THR55Q, THR57Q, TRP12Q, TRP52W, TYR59W, VAL26Q, VAL54Q
• R-S: ARG73S, LYS71S, PHE10R, TYR13R
• R-T: ALA12R, ALA25T, ARG14R, ARG15R, ARG24T, ARG32R, ASN28T, ASP17R, ASP31R, ASP32T, ASP4R, ASP9R, GLN23T, GLN26R, GLU16R, GLU22T, GLY34R, HIS2R, ILE14T, ILE26T, LEU18T, LEU38R, LYS33R, MET19R, PHE10R, PHE21T, PHE35R, PRO20T, PRO27T, PRO8R, SER11R, SER17T, SER19T, SER25R, SER28R, SER29R, SER31T, SER36R, THR15T, THR40R, THR6R, TYR13R, TYR16T, TYR37R, VAL18R, VAL1R, VAL39R, VAL5R, VAL7R
• R-W: ALA12W, ALA21W, ALA28W, ALA34W, ALA39W, ALA41R, ALA43R, ALA46R, ALA48R, ALA4W, ALA50R, ALA9W, ARG15R, ARG15W, ARG32R, ARG33W, ARG7W, ASN53R, ASP17R, ASP31R, ASP36W, CYS44R, GLN26R, GLN37W, GLN8W, GLU30R, GLU32W, GLY27W, GLY34R, LEU13W, LEU22W, LEU26W, LEU30W, LEU38R, LEU5W, LEU6W, LYS33R, LYS52R, PHE14W, PHE20W, PHE31W, PHE35R, PHE35W, SER11W, SER28R, SER29R, SER36R, THR23W, THR27R, THR40R, THR42R, THR47R, THR56R, TYR10W, TYR37R, TYR49R, VAL24W, VAL25W, VAL29W, VAL39R, VAL45R
• S-T: ALA23S, ALA24S, ALA33T, ALA8T, ARG11T, ARG39T, ARG40T, ARG58S, ARG61S, ARG64S, ARG73S, ARG9T, ASN22S, ASN28T, ASN36T, ASN56S, ASP32T, ASP53S, ASP67S, GLU52S, GLU57S, GLY25S, HIS12T, HIS72S, ILE13T, ILE14T, ILE29T, ILE62S, ILE74S, LEU34T, LEU68S, LEU75S, LEU7T, LYS28S, LYS47T, LYS63S, LYS71S, MET59S, PHE60S, PRO27T, PRO35T, SER17T, SER31T, SER43T, SER69S, THR15T, TRP38T, TRP80S, TYR16T, TYR29S, TYR55S, VAL10T, VAL37T
• T-U: ARG36U, ARG43U, ARG47U, ARG71T, ASN73T, ASN79T, ASP41U, ASP60U, ASP76T, ASP80T, CYS40U, CYS54U, GLN53U, GLU51U, GLU52U, GLU56U, GLU57U, GLU78T, HIS49U, LEU37U, LEU58U, LYS70T, LYS72T, PHE59U, PRO74T, SER46U, SER48U, THR50U, THR55U, TYR77T, VAL44U
• T-W: PHE21T, TYR10W
• U-W: LYS58W, LYS78U