3L5Q

proteasome activator complex

• Total interactions analyzed: 561
• Total true interactions: 102
• Strongest Interaction:
  • Chains: J-5
  • Int. Res.: 4
  • Norm. En. per Res.: -5.236
• Hub Node: A(6)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-G	-72.914	-11.2401	-352.179	-436.3331	124	26	10	14052	2	21	25
A-L	-48.4188	-35.0576	-360.655	-444.1314	130	18	9	14541	2	26	26
A-B	-11.5487	-26.7419	-86.2693	-124.5598	48	1	4	3663	2	12	16
A-M	-22.6572	-76.3618	-168.462	-267.4811	60	8	1	6208	8	14	21
A-4	0.0	0.0	-10.5443	-10.5443	15	1	0	548	0	3	4
A-5	-10.291	-38.5194	0.0	-48.8104	15	0	0	0	0	0	0
G-H	-22.7994	-17.8419	-149.81	-190.4513	74	7	4	6970	1	15	12
G-M	-52.886	-39.9192	-166.389	-259.1942	77	7	3	6358	4	16	17
G-N	-3.3558	9.2184	-105.857	-99.9944	52	5	2	4661	1	16	22
G-5	0.0	-5.0544	0.0	-5.0544	9	0	0	0	0	0	0
G-6	0.0	-4.8708			2
H-I	-45.6412	-6.7889	-282.871	-335.3011	115	25	4	11825	1	24	27
H-M	0.0	15.9592	-7.7935	8.1657	11	0	0	266	0	5	4
H-N	-11.3509	-3.8028	-108.647	-123.8007	50	1	1	4748	0	17	23
H-O	-27.0828	-34.0774	-131.442	-192.6023	50	4	2	4903	4	22	24
H-6	0.0	9.1141			9
I-J	-15.509	-27.3998	-165.159	-208.0679	78	17	4	7478	3	17	14
I-O	-9.3482	-11.8425	-85.5877	-106.7784	44	3	3	3968	1	16	13
I-P	-20.0398	-77.1155	-76.8172	-173.9725	48	1	1	3480	7	41	28
I-6	-14.7907	-7.3654			25
J-K	-38.3074	-48.181	-279.985	-366.4735	125	16	8	11765	3	38	30
J-P	-23.8577	-37.6851	-91.1388	-152.6816	49	5	1	4152	6	28	28
J-Q	0.0	-32.6802	-143.498	-176.1782	54	1	0	4711	4	30	26
J-5	-7.6253	-13.3189	0.0	-20.9441	4	0	0	0	0	0	0
J-6	-13.148	38.7158			25
K-L	-40.2199	-31.0286	-372.795	-444.0435	133	13	11	14776	1	31	33
K-Q	-16.2907	-29.1504	-81.4089	-126.85	41	8	0	3345	4	13	17
K-R	-11.2498	-35.8152	-139.982	-187.047	57	0	3	5271	2	29	12
K-5	-23.9199	26.3714	0.0	2.4516	9	0	0	0	0	0	0
K-6	-79.8459	-86.6142			25
L-B	-16.1345	-9.7643	-106.191	-132.0899	50	3	4	4611	0	15	10
L-R	-21.0996	-79.2431	-107.108	-207.4507	57	4	2	4482	6	33	22
L-5	-10.1463	12.1407	0.0	1.9944	7	0	0	0	0	0	0
B-M	-36.1727	-49.9699	-87.8429	-173.9856	65	5	3	3924	3	15	5
B-R	-28.0183	-24.3197	-161.592	-213.93	70	13	1	6874	5	22	18
B-D	-13.8592	-18.6903	-190.979	-223.5284	55	6	3	6898	4	12	11
B-4	-72.6059	3.3808	-329.076	-398.3011	113	21	9	13706	3	28	31
M-N	-95.8508	-127.3655	-357.991	-581.2073	144	14	14	15297	8	44	35
M-2	0.0	0.0	-9.3525	-9.3525	7	0	1	492	0	0	0
M-3	-79.63	-67.2165	-324.718	-471.5645	118	44	6	14491	4	34	39
M-4	-17.7826	-38.0138	-184.259	-240.0554	91	12	5	9191	1	21	21
N-O	-29.1152	-58.3675	-119.082	-206.5647	75	13	4	6001	3	13	11
N-2	-34.2832	-56.8969	-244.256	-335.436	90	10	4	9610	3	21	20
N-3	-47.0968	-25.9586	-185.999	-259.0544	77	14	1	7732	4	19	21
O-P	-11.0368	-57.4158	-147.374	-215.8266	66	8	4	6416	5	21	22
O-1	-46.5339	-37.8487	-163.108	-247.4906	54	8	2	6675	2	21	31
O-2	-38.5517	-46.4636	-201.678	-286.6933	75	15	2	7996	5	20	17
P-Q	-44.6692	-40.2824	-191.608	-276.5595	88	10	4	6708	3	25	18
P-Y	0.0	0.0	-9.4568	-9.4568	7	0	1	497	0	0	0
P-Z	-34.2316	-57.7123	-250.893	-342.837	91	10	4	9818	3	21	20
P-1	-38.4481	-43.1457	-203.172	-284.7658	76	17	2	8036	3	20	17
Q-R	-31.2936	-90.7597	-244.904	-366.9573	97	14	6	10066	10	29	23
Q-Y	-84.4822	-67.2595	-341.902	-493.6437	119	45	6	14691	4	34	39
Q-Z	-48.176	-25.2616	-192.322	-265.7596	77	14	1	7851	4	19	21
R-C	0.0	0.0	-11.0757	-11.0757	15	1	0	564	0	3	4
R-D	-74.9917	3.4037	-340.985	-412.573	115	21	9	13870	4	29	31
R-Y	-17.8692	-37.8502	-198.64	-254.3594	91	12	5	9223	1	21	21
C-S	-70.1633	-11.425	-352.988	-434.5763	123	26	10	14044	2	21	25
C-X	-48.7703	-34.3646	-376.744	-459.8789	130	15	9	14516	2	26	26
C-D	-10.0049	-26.3735	-86.5069	-122.8853	48	1	4	3659	2	12	16
C-Y	-17.5571	-77.7785	-158.859	-254.1946	60	13	2	6333	9	14	22
C-7	-5.4309	-60.7383			15
S-T	-20.587	-17.7514	-150.234	-188.5724	75	5	4	6963	1	15	12
S-Y	-50.3609	-39.9186	-167.557	-257.8366	78	12	3	6396	4	16	17
S-Z	0.0	9.4462	-110.093	-100.6468	54	3	2	4765	1	16	22
S-7	-2.6637	-5.4608			9
S-8	0.0	-5.5191			2
T-U	-43.5238	-7.454	-285.343	-336.3208	116	22	4	11867	1	24	27
T-Y	0.0	16.0215	-7.9981	8.0234	11	0	0	274	0	5	4
T-Z	-11.2601	-3.7952	-111.176	-126.2313	50	4	1	4839	0	17	22
T-1	-23.8484	-34.8227	-132.516	-191.1871	52	6	2	4995	4	22	24
T-8	0.0	8.5191			9
U-V	-29.2187	-27.8846	-165.307	-222.4103	79	17	4	7504	3	17	14
U-1	-3.9009	-11.7865	-83.5301	-99.2175	45	2	2	3940	1	16	13
U-2	-15.9444	-77.189	-80.0583	-173.1917	48	1	1	3523	8	41	28
U-8	-23.5314	-25.0781			26
V-W	-39.5228	-48.8948	-280.347	-368.7646	125	15	8	11753	3	38	30
V-2	-8.5018	-37.5343	-87.8267	-133.8628	49	5	1	4053	6	27	28
V-3	0.0	-33.1525	-142.701	-175.8535	54	1	0	4753	4	31	26
V-7	0.0	-11.3095			4
V-8	-10.4803	36.7187			24
W-X	-52.5163	-31.8619	-378.476	-462.8542	131	13	11	14817	1	31	33
W-3	-17.0393	-28.0406	-78.4727	-123.5526	40	4	0	3263	2	13	17
W-4	-11.0114	-36.156	-143.283	-190.4504	57	1	3	5374	2	29	12
W-7	-24.8113	30.4027			9
W-8	-73.9652	-81.0259			25
X-D	-24.2684	-9.857	-108.475	-142.6004	50	3	4	4668	0	15	10
X-4	-22.1751	-37.4964	-103.227	-162.8985	57	5	2	4360	6	33	22
X-7	-11.1023	9.769			6
D-Y	-50.3172	-48.5331	-90.1924	-189.0427	65	6	3	3936	3	15	5
D-4	-27.7027	-24.5332	-159.632	-211.8679	69	13	1	6870	6	22	18
Y-Z	-93.5049	-127.7238	-358.549	-579.7777	144	13	13	15371	8	44	35
Z-1	-29.8816	-58.9284	-119.908	-208.718	74	11	4	6030	3	12	11
1-2	-13.881	-57.2261	-147.31	-218.4171	66	11	4	6426	5	21	22
2-3	-44.5747	-40.6073	-187.766	-272.948	88	9	4	6683	3	25	18
3-4	-24.912	-90.0233	-256.002	-370.9373	97	12	6	10249	11	28	24
E-5	-34.7333	-116.9282	-241.157	-392.8185	94	15	9	10686	2	20	24
E-6	-13.9303	-19.6232			11
5-6	-87.7391	-131.7482			74
F-7	-34.7154	-115.2725			16
F-8	-13.8698	-20.3874			11
7-8	-85.2362	-132.5712			76

Interface residues

• A-G: ALA1044A, ALA1118A, ALA1122A, ALA1132A, ALA1160A, ALA1168A, ALA1170A, ALA2024G, ALA2027G, ALA2056G, ALA2121G, ARG1024A, ARG1046A, ARG1120A, ARG1131A, ARG2083G, ARG2090G, ARG2128G, ASN1123A, ASN1181A, ASN1184A, ASP1013A, ASP1115A, ASP1158A, ASP1192A, ASP2022G, ASP2081G, ASP2087G, GLN1126A, GLN1130A, GLN1175A, GLN1176A, GLN2020G, GLN2030G, GLU1022A, GLU1183A, GLU2059G, GLY1023A, GLY1161A, GLY1165A, GLY2079G, GLY2125G, GLY2126G, GLY2131G, HIS1185A, HIS1193A, ILE1016A, ILE1018A, ILE1127A, ILE1154A, ILE1178A, ILE1191A, ILE2021G, LEU1025A, LEU1043A, LEU1124A, LEU1150A, LEU1182A, LEU2025G, LEU2055G, LEU2061G, LEU2085G, LYS1107A, LYS1119A, LYS1156A, LYS1167A, LYS1187A, LYS2029G, LYS2049G, LYS2050G, LYS2063G, LYS2088G, LYS2091G, MET1121A, MET1134A, MET2057G, MET2078G, MET2118G, PHE1019A, PHE1186A, PHE2130G, PRO1021A, PRO1152A, PRO1159A, PRO2054G, PRO2080G, PRO2129G, PRO2152G, SER1020A, SER1125A, SER1153A, SER2051G, SER2052G, SER2053G, SER2058G, SER2062G, SER2065G, SER2124G, THR1017A, THR1129A, THR1157A, THR1169A, THR1179A, THR1180A, THR2026G, THR2060G, TYR1012A, TYR1128A, TYR1133A, TYR1155A, TYR1162A, TYR1163A, TYR1166A, TYR2023G, TYR2075G, TYR2082G, VAL1028A, VAL1045A, VAL1164A, VAL2028G, VAL2084G, VAL2086G, VAL2127G, VAL2132G
• A-L: ALA1010A, ALA1031A, ALA1034A, ALA1090A, ALA1093A, ALA1094A, ALA1132A, ALA7112L, ALA7121L, ALA7145L, ALA7162L, ALA7163L, ALA7171L, ALA7173L, ARG1014A, ARG1091A, ARG1096A, ARG1131A, ARG1135A, ARG7019L, ARG7114L, ARG7168L, ASN1036A, ASN1092A, ASN1221A, ASN7011L, ASN7020L, ASN7126L, ASP1013A, ASP1061A, ASP1065A, ASP1089A, ASP7008L, ASP7017L, ASP7113L, ASP7180L, GLN1027A, GLN1037A, GLN7117L, GLN7120L, GLN7169L, GLU1029A, GLU7024L, GLU7151L, GLU7174L, GLU7176L, GLY1011A, GLY1085A, GLY1138A, GLY7004L, GLY7006L, GLY7018L, GLY7038L, GLY7116L, GLY7154L, GLY7158L, GLY7161L, HIS1015A, HIS7122L, HIS7146L, ILE1016A, ILE1040A, ILE1087A, ILE7039L, LEU1063A, LEU1064A, LEU1095A, LEU1137A, LEU7009L, LEU7124L, LEU7147L, LEU7150L, LEU7175L, LEU7178L, LYS1033A, LYS1062A, LYS1098A, LYS7040L, LYS7160L, LYS7172L, LYS7177L, MET1134A, MET7149L, PHE1032A, PHE1073A, PHE7014L, PHE7137L, PRO1060A, PRO1066A, PRO1086A, PRO1088A, PRO1136A, PRO1159A, PRO7016L, PRO7109L, PRO7152L, SER1070A, SER7010L, SER7012L, SER7015L, SER7127L, SER7153L, SER7155L, THR1017A, THR1035A, THR1038A, THR1067A, THR1068A, THR7005L, THR7123L, TRP7157L, TYR1012A, TYR1026A, TYR1030A, TYR1071A, TYR1128A, TYR1133A, TYR7007L, TYR7125L, TYR7148L, TYR7156L, TYR7159L, VAL1028A, VAL1059A, VAL1069A, VAL1139A, VAL7013L, VAL7023L, VAL7119L, VAL7179L
• A-B: ALA1054B, ALA1056B, ALA1094A, ALA1097A, ALA1099A, ALA1101A, ALA1102A, ARG1036B, ARG1077A, ARG1096A, ARG1105A, ASP1039B, ASP1057B, ASP1111A, CYS1074A, GLN1053B, GLN1060B, GLN1069B, GLU1064B, GLU1100A, GLU1103A, GLY1071B, HIS1038B, HIS1062B, ILE1055B, ILE1058B, ILE1075A, LEU1063B, LEU1065B, LEU1095A, LYS1098A, LYS1107A, LYS1232A, MET1112A, PHE1073A, PHE1104A, SER1068B, SER1076A, THR1067B, THR1072B, THR1078A, TYR1061B, TYR1066B, TYR1070B, TYR1106A, TYR1110A, VAL1037B, VAL1059B
• A-M: ALA1118A, ALA1122A, ALA2079M, ARG1105A, ARG1120A, ARG2072M, ARG2075M, ASN1123A, ASN2062M, ASP1111A, ASP1115A, ASP1147A, ASP2104M, CYS1114A, GLN2081M, GLN2085M, GLU1100A, GLU1148A, GLU1149A, GLU2073M, GLY1109A, GLY1151A, HIS2066M, ILE1079A, ILE2059M, ILE2063M, LEU1117A, LEU1124A, LEU1150A, LEU2065M, LEU2068M, LEU2080M, LEU2083M, LYS1107A, LYS1119A, LYS2084M, MET1112A, MET1121A, MET2082M, PHE1104A, PHE2088M, PRO1113A, PRO2074M, PRO2105M, SER1145A, SER1153A, SER2067M, SER2071M, SER2078M, THR2070M, THR2106M, TYR1106A, TYR1108A, TYR1110A, TYR1155A, TYR1163A, TYR2069M, VAL1116A, VAL2076M, VAL2077M
• A-4: ARG1077A, ARG1105A, ASP1111A, ASP1231A, GLN72234, GLU1148A, GLY1109A, GLY72214, ILE72254, LYS72244, THR1078A, THR72224, TYR1106A, TYR1108A, TYR1110A
• A-5: ARG1014A, ARG8675, ASN1036A, ASP7675, ASP7695, ASP8095, GLU1029A, GLU1177A, GLU1183A, GLU8135, LYS1033A, LYS1174A, LYS8125, LYS8145, LYS8705
• G-H: ALA2115G, ALA2161G, ALA2163G, ALA2171G, ALA3082H, ARG2178G, ARG3050H, ARG3092H, ARG3129H, ASN2143G, ASN2180G, ASN3089H, ASP3060H, ASP3083H, ASP3209H, GLN2119G, GLN2123G, GLN2149G, GLN3059H, GLU2113G, GLU2120G, GLU2176G, GLU3058H, GLU3064H, GLU3085H, GLY2036G, GLY2125G, GLY2154G, GLY3132H, ILE2021G, ILE2037G, ILE2117G, ILE3086H, LEU2109G, LEU2147G, LEU2175G, LEU3056H, LEU3057H, LEU3080H, LEU3128H, LYS2038G, LYS2108G, LYS2116G, LYS2160G, LYS2172G, LYS2177G, LYS3051H, PHE2145G, PHE2157G, PHE2174G, PHE3131H, PRO2158G, PRO3130H, SER2112G, SER2124G, SER2146G, SER2153G, SER2155G, SER3054H, SER3062H, THR2122G, THR2162G, THR2173G, THR3053H, THR3055H, THR3061H, THR3063H, THR3081H, TRP2159G, TRP2179G, TYR2148G, TYR2156G, TYR3067H, TYR3122H
• G-M: ALA2093G, ALA2184M, ARG2036M, ARG2083G, ARG2090G, ARG2099G, ARG2188M, ASN2062M, ASP2087G, ASP2183M, ASP2220G, ASP2230G, CYS2176M, GLN2057M, GLU2064M, GLU2073M, GLU2103G, GLU2185M, GLY2060M, GLY2102G, GLY2223G, GLY2226G, HIS2035M, HIS2066M, HIS2094G, ILE2037M, ILE2041M, ILE2059M, ILE2063M, ILE2100G, ILE2227G, LEU2034M, LEU2058M, LEU2065M, LEU2066G, LEU2067G, LEU2068M, LEU2187M, LEU2221G, LEU2222G, LYS2040M, LYS2088G, LYS2091G, LYS2098G, LYS2182M, MET2082M, MET2178M, PRO2039M, PRO2069G, PRO2219G, PRO2228G, SER2038M, SER2061M, SER2062G, SER2065G, SER2067M, SER2071M, SER2089G, THR2056M, THR2060G, THR2068G, THR2070M, THR2095G, THR2225G, THR2229G, TRP2042M, TYR2069M, TYR2101G, TYR2104G, TYR2186M, TYR2224G, VAL2084G, VAL2086G, VAL2092G, VAL2103M, VAL2175M, VAL2177M
• G-N: ALA3072N, ARG2099G, ARG3071N, ASN2143G, ASN3104N, ASP2140G, GLN3080N, GLU2103G, GLU2113G, GLU2141G, GLU3069N, GLU3070N, GLU3074N, GLU3076N, GLU3088N, GLY2102G, GLY2144G, HIS3039N, ILE2100G, ILE3073N, ILE3121N, LEU2109G, LEU3064N, LEU3067N, LEU3081N, LYS2098G, LYS2108G, LYS3061N, LYS3068N, LYS3106N, LYS3109N, PHE2142G, PHE3078N, PRO2105G, PRO2106G, PRO3075N, SER2096G, SER2112G, SER3083N, SER3084N, SER3085N, SER3105N, SER3107N, THR2229G, THR3062N, THR3077N, THR3079N, TYR2097G, TYR2101G, TYR2104G, TYR3065N, VAL3082N
• G-5: ARG10035, ARG8595, GLU10075, GLU2201G, GLU2203G, GLU8635, HIS10045, LYS2050G, LYS2197G
• G-6: GLU11956, LYS2177G
• H-I: ALA3040H, ALA3162H, ALA3172H, ALA4023I, ALA4026I, ALA4080I, ARG3018H, ARG3113H, ARG3114H, ARG3143H, ARG4029I, ARG4048I, ARG4058I, ARG4083I, ARG4090I, ARG4127I, ASN3152H, ASN3156H, ASN4079I, ASP3117H, ASP3179H, ASP3182H, ASP4056I, ASP4081I, GLN3120H, GLN3124H, GLN3147H, GLN3173H, GLN3177H, GLN4019I, GLN4055I, GLN4117I, GLU3016H, GLU3023H, GLU3109H, GLU4021I, GLU4025I, GLU4087I, GLY3017H, GLY3037H, GLY3121H, GLY3126H, GLY3127H, GLY3145H, GLY3155H, GLY3159H, GLY4077I, GLY4124I, GLY4125I, GLY4130I, HIS3125H, ILE3038H, ILE3044H, ILE3118H, ILE3163H, ILE4059I, ILE4084I, ILE4086I, LEU3019H, LEU3115H, LEU3128H, LEU3148H, LEU3175H, LEU3176H, LEU3192H, LEU4024I, LEU4052I, LEU4054I, LEU4078I, LEU4085I, LYS3119H, LYS3161H, LYS3181H, LYS4028I, LYS4053I, LYS4088I, MET3039H, MET3178H, PHE4075I, PHE4129I, PRO3015H, PRO3153H, PRO4061I, PRO4128I, SER3014H, SER3041H, SER3116H, SER3151H, SER3154H, SER3164H, SER4062I, SER4082I, THR3123H, THR3158H, THR3174H, THR4051I, THR4057I, THR4060I, TRP3160H, TYR3020H, TYR3122H, TYR3144H, TYR3146H, TYR3149H, TYR3157H, TYR3180H, TYR4022I, TYR4120I, VAL3022H, VAL3108H, VAL3112H, VAL4027I, VAL4116I, VAL4126I, VAL4131I
• H-M: ALA3220H, ASN2219M, ASP2222M, ASP3071H, CYS2221M, GLN3227H, GLU3224H, LYS3068H, LYS3072H, TYR3226H, VAL3225H
• H-N: ALA3091H, ALA3095H, ARG3059N, ARG3092H, ASN3055N, ASN3063N, ASN3070H, ASN3089H, ASN3097H, ASN3103H, ASP3071H, ASP3105H, GLN3096H, GLN3227H, GLU3056N, GLU3069N, GLU3070N, GLU3104H, HIS3094H, ILE3073H, ILE3088H, ILE3093H, ILE3229H, LEU3054N, LEU3064N, LEU3067N, LEU3069H, LEU3099H, LYS3061N, LYS3066N, LYS3068H, LYS3068N, LYS3072H, LYS3100H, MET3057N, PHE3058N, SER3062H, THR3052N, THR3053N, THR3061H, THR3062N, THR3063H, THR3090H, THR3101H, TYR3060N, TYR3065N, TYR3067H, TYR3094N, TYR3098H, TYR3102H
• H-O: ALA4078O, ALA4088O, ARG3113H, ARG3143H, ARG4069O, ARG4084O, ASN3097H, ASN3103H, ASN4062O, ASP3105H, ASP3141H, ASP3142H, ASP4071O, ASP4107O, GLN4077O, GLN4085O, GLU3104H, GLU3109H, GLU4070O, GLU4073O, GLU4086O, GLY3145H, HIS3094H, ILE3106H, ILE3110H, ILE4063O, LEU3099H, LEU4074O, LYS3100H, LYS4089O, LYS4109O, LYS4110O, LYS4124O, PHE4082O, PRO3107H, PRO4076O, SER4067O, SER4075O, SER4080O, SER4081O, THR3101H, TYR3098H, TYR3102H, TYR3144H, TYR3157H, TYR4066O, TYR4072O, TYR4116O, VAL4079O, VAL4083O
• H-6: ASP13836, ASP3179H, ASP3202H, ASP3209H, GLU13756, GLU14976, HIS14956, LYS14946, LYS3199H
• I-J: ALA4114I, ALA4161I, ALA5083J, ALA5085J, ARG4111I, ARG4119I, ARG4172I, ARG4181I, ARG5086J, ARG5093J, ARG5136J, ASN4178I, ASN5215J, ASP4180I, ASP5062J, ASP5084J, GLN4118I, GLN4122I, GLN4149I, GLN4162I, GLN5023J, GLU4107I, GLU4151I, GLU4173I, GLU4176I, GLU5060J, GLU5065J, GLU5090J, GLU5125J, GLY4035I, GLY4115I, GLY4124I, GLY4125I, GLY4154I, GLY5080J, GLY5139J, ILE4017I, ILE4155I, ILE5064J, LEU4147I, LEU4175I, LEU5058J, LEU5059J, LEU5081J, LEU5133J, LYS4037I, LYS4146I, LYS4177I, MET5088J, MET5134J, PHE4174I, PHE5138J, PRO4145I, PRO5057J, PRO5137J, SER4123I, SER4153I, SER4157I, SER4158I, SER4160I, SER5056J, SER5061J, SER5063J, SER5087J, SER5135J, THR4121I, THR4163I, THR5055J, THR5082J, TRP4159I, TYR4148I, TYR4156I, TYR4179I, VAL4020I, VAL4036I, VAL4126I, VAL4171I, VAL5012J
• I-O: ALA4056O, ALA4061O, ALA4089I, ALA4093I, ARG4035O, ARG4069O, ARG4090I, ARG4097I, ASN4062O, ASP4068I, ASP4071O, GLN4054O, GLN4060O, GLN4064O, GLN4094I, GLU4057O, GLU4070O, GLU4087I, GLU4092I, GLU4101I, HIS4070I, HIS4096I, ILE4059O, ILE4063O, ILE4067I, ILE4068O, ILE4086I, ILE4221I, LEU4065O, LEU4098I, LYS4066I, LYS4088I, PHE4055O, SER4062I, SER4065I, SER4067O, SER4069I, SER4095I, THR4099I, TYR4058O, TYR4066O, VAL4053O, VAL4071I, VAL4091I
• I-P: ALA5077P, ALA5078P, ALA5079P, ARG4097I, ARG4111I, ARG4141I, ARG5069P, ARG5106P, ARG5121P, ASN5085P, ASP4102I, ASP4139I, ASP4142I, CYS5063P, GLN5062P, GLU4101I, GLU4107I, GLU5070P, GLU5072P, GLU5108P, GLY5109P, HIS4096I, HIS5066P, ILE5074P, ILE5082P, LEU4098I, LEU4100I, LEU4109I, LEU5068P, LEU5083P, LYS5071P, LYS5081P, LYS5107P, LYS5123P, PRO4140I, SER5075P, SER5080P, SER5084P, THR4099I, THR4105I, THR5105P, THR5111P, TYR4108I, TYR4148I, TYR4156I, TYR5113P, VAL4104I, VAL5076P
• I-6: ARG4049I, ARG4166I, ASP16666, ASP16676, ASP17156, ASP17956, GLN17606, GLN4204I, GLU16236, GLU17116, GLU17186, GLU17536, GLU4173I, GLU4176I, GLU4201I, GLU4237I, HIS17146, HIS17596, LYS16686, LYS18736, LYS4053I, LYS4169I, LYS4177I, LYS4208I, LYS4240I
• J-K: ALA5041J, ALA5127J, ALA5169J, ALA5171J, ALA5179J, ALA5181J, ALA6025K, ALA6028K, ALA6053K, ALA6078K, ALA6081K, ARG5005J, ARG5020J, ARG5122J, ARG5132J, ARG5166J, ARG6003K, ARG6051K, ARG6082K, ARG6089K, ARG6126K, ASN5168J, ASN5185J, ASN6004K, ASN6005K, ASN6052K, ASN6086K, ASN6119K, ASP5118J, ASP6007K, ASP6009K, ASP6054K, ASP6080K, CYS5117J, GLN5114J, GLN5180J, GLN6021K, GLN6031K, GLN6060K, GLN6090K, GLN6117K, GLN6121K, GLU5007J, GLU5018J, GLU5025J, GLU5110J, GLU5125J, GLU5130J, GLU5182J, GLU5186J, GLU6023K, GLU6027K, GLU6055K, GLY5011J, GLY5019J, GLY5039J, GLY5124J, GLY5126J, GLY5129J, GLY5162J, GLY6008K, GLY6124K, GLY6125K, GLY6129K, HIS5157J, HIS5188J, ILE5040J, ILE6029K, ILE6064K, LEU5021J, LEU5119J, LEU5121J, LEU5155J, LEU5183J, LEU5184J, LEU5199J, LEU6026K, LEU6056K, LEU6074K, LEU6077K, LYS5170J, LYS6030K, LYS6050K, LYS6061K, LYS6115K, LYS6118K, MET6001K, PHE5015J, PHE5123J, PHE5156J, PHE5164J, PHE6002K, PHE6020K, PRO5017J, PRO6079K, PRO6127K, PRO6149K, SER5006J, SER5013J, SER5016J, SER5111J, SER5115J, SER5128J, SER5161J, SER6057K, SER6058K, SER6122K, THR5014J, THR5163J, THR6010K, THR6120K, TRP5187J, TYR5008J, TYR5165J, TYR5167J, TYR6024K, TYR6059K, TYR6087K, TYR6123K, TYR6128K, VAL5012J, VAL5024J, VAL6022K, VAL6083K, VAL6130K
• J-P: ALA5092J, ALA5095J, ALA5096J, ARG5064P, ARG5069P, ARG5072J, ARG5086J, ARG5093J, ASN5100J, ASP5062J, ASP5071J, ASP5104J, ASP5106J, CYS5063P, GLN5053P, GLN5062P, GLU5056P, GLU5065J, GLU5067P, GLU5069J, GLU5070P, GLU5090J, GLY5060P, HIS5066P, HIS5073J, HIS5091J, ILE5067J, ILE5070J, ILE5074J, ILE5089J, ILE5230J, LEU5059P, LEU5065P, LEU5068P, LEU5101J, LYS5071P, PHE5054P, PHE5228J, PRO5039P, SER5061P, SER5063J, THR5057P, THR5094J, THR5098J, TRP5055P, TRP5058P, TYR5102J, VAL5068J, VAL5097J
• J-Q: ALA5095J, ALA5096J, ALA5149J, ALA6080Q, ALA6081Q, ARG6082Q, ASN5100J, ASN5108J, ASN6071Q, ASN6078Q, ASN6083Q, ASP5104J, ASP5106J, ASP5148J, ASP5150J, ASP5151J, ASP6069Q, GLN5114J, GLN6085Q, GLU5105J, GLU5110J, GLU6107Q, GLY6090Q, HIS5099J, HIS6067Q, HIS6070Q, HIS6086Q, ILE5107J, ILE6077Q, ILE6084Q, LEU5101J, LEU5112J, LEU6075Q, LEU6087Q, LYS6073Q, LYS6074Q, PHE6059Q, PHE6068Q, SER5111J, SER5115J, SER6062Q, SER6076Q, SER6079Q, THR5098J, TRP6065Q, TYR5102J, TYR5103J, TYR6066Q, TYR6089Q, TYR6114Q, TYR6122Q, VAL5097J, VAL5109J, VAL6063Q
• J-5: ARG5005J, GLU5007J, HIS5235, LYS5895
• J-6: ARG21396, ARG5005J, ARG5020J, ARG5053J, ASP19196, ASP21166, ASP5009J, ASP5213J, GLU20056, GLU5007J, GLU5018J, GLU5025J, GLU5051J, GLU5159J, GLU5177J, GLU5209J, GLU5210J, HIS19176, LYS19186, LYS21116, LYS21126, LYS5211J, SER21086, TYR20746, TYR21416
• K-L: ALA6116K, ALA6142K, ALA6160K, ALA6168K, ALA7026L, ALA7029L, ARG6018K, ARG6039K, ARG6107K, ARG6174K, ARG7085L, ARG7092L, ARG7129L, ASN6005K, ASN6119K, ASN6152K, ASN7011L, ASN7032L, ASN7063L, ASN7089L, ASN7126L, ASP6007K, ASP6009K, ASP6114K, ASP6138K, ASP6177K, ASP7008L, ASP7083L, CYS6113K, GLN6117K, GLN6121K, GLN6148K, GLN7022L, GLN7061L, GLN7067L, GLU6106K, GLU6146K, GLU6155K, GLU6173K, GLU7024L, GLU7031L, GLU7093L, GLY6008K, GLY6017K, GLY6037K, GLY6109K, GLY6124K, GLY6141K, GLY6151K, GLY6158K, GLY7006L, GLY7079L, GLY7084L, GLY7132L, HIS6110K, HIS6143K, HIS7086L, HIS7122L, ILE6180K, ILE7053L, ILE7081L, LEU6019K, LEU6038K, LEU6111K, LEU6112K, LEU6144K, LEU6145K, LEU6156K, LEU6172K, LEU6176K, LEU7009L, LEU7052L, LEU7057L, LEU7058L, LEU7080L, LEU7087L, LYS6115K, LYS6118K, LYS6169K, LYS7028L, LYS7051L, LYS7056L, LYS7062L, LYS7065L, LYS7209L, PHE6013K, PHE6179K, PHE7021L, PHE7131L, PRO6015K, PRO6127K, PRO6149K, PRO7060L, PRO7082L, PRO7130L, PRO7152L, SER6014K, SER6122K, SER6140K, SER6150K, SER7010L, SER7012L, SER7055L, SER7127L, THR6010K, THR6012K, THR6016K, THR6120K, THR6154K, THR6159K, THR6170K, THR6175K, THR7054L, TYR6006K, TYR6123K, TYR6157K, TYR6171K, TYR7007L, TYR7025L, TYR7118L, TYR7125L, VAL6011K, VAL6022K, VAL6105K, VAL6153K, VAL7023L, VAL7027L, VAL7030L, VAL7059L, VAL7064L, VAL7088L, VAL7128L, VAL7133L
• K-Q: ARG6058Q, ARG6082K, ARG6089K, ASN6061Q, ASN6071Q, ASN6086K, ASN6093K, ASN6100K, ASP6067K, ASP6069Q, ASP6072Q, CYS6066K, CYS6092K, GLN6090K, GLN6091K, GLU6068K, HIS6067Q, HIS6069K, HIS6070Q, ILE6064K, ILE6224K, LEU6088K, LEU6097K, LEU6103K, LYS6057Q, LYS6060Q, LYS6061K, LYS6064Q, LYS6065K, LYS6102K, MET6070K, PHE6068Q, PHE6099K, SER6062Q, SER6085K, SER6095K, SER6096K, TRP6065Q, TYR6087K, TYR6094K, VAL6098K
• K-R: ALA6104K, ALA7067R, ALA7073R, ALA7075R, ALA7078R, ALA7089R, ARG6101K, ARG6107K, ASN6100K, ASN7066R, ASN7070R, ASN7114R, ASP6114K, ASP6138K, ASP7069R, GLN7094R, GLN7112R, GLU6106K, GLU7065R, GLU7076R, GLU7077R, GLU7080R, GLU7086R, GLY6141K, HIS6069K, HIS6110K, HIS6143K, ILE7084R, LEU6097K, LEU6103K, LEU6111K, LEU7058R, LEU7059R, LEU7062R, LEU7072R, LEU7079R, LEU7088R, LYS6102K, LYS6139K, PHE6099K, PHE7085R, PHE7118R, PRO7071R, PRO7081R, SER6095K, SER6096K, SER6140K, SER7082R, SER7113R, THR7090R, TYR6094K, TYR7068R, TYR7083R, TYR7087R, VAL6098K, VAL6105K, VAL7091R
• K-5: ARG6003K, ARG6355, ARG6375, ASN6005K, GLN5875, HIS6365, LYS5895, MET6001K, SER6345
• K-6: ALA21436, ALA6078K, ARG20486, ARG20946, ARG6003K, ARG6164K, ARG6202K, ASP21166, ASP21326, ASP6203K, GLN20496, GLN6031K, GLU20476, GLU21316, GLU21346, GLU6027K, GLU6055K, GLU6204K, GLY6076K, LYS20536, LYS21116, LYS6030K, LYS6062K, PHE6002K, TYR21416
• L-B: ALA1078B, ALA1079B, ALA7110L, ARG7114L, ASN1106B, ASN7143L, ASP1103B, ASP7113L, GLN1069B, GLN7117L, GLU1076B, GLU1084B, GLU1088B, GLU7094L, GLY1071B, HIS1062B, ILE1058B, ILE7106L, LEU1063B, LEU1065B, LEU1085B, LEU7101L, LYS1083B, LYS1105B, LYS7099L, LYS7100L, LYS7103L, LYS7142L, PHE1082B, PHE7098L, PHE7111L, PRO1073B, PRO7105L, PRO7107L, PRO7109L, SER1074B, SER1080B, SER7097L, THR1072B, THR1075B, THR1077B, THR7104L, TYR1066B, TYR1070B, TYR1087B, TYR1111B, TYR7102L, VAL1059B, VAL1081B, VAL1119B
• L-R: ALA7067R, ALA7073R, ALA7075R, ALA7095L, ALA7096L, ARG7057R, ARG7071L, ARG7085L, ARG7092L, ASN7063L, ASN7066R, ASN7070R, ASN7089L, ASP7061R, ASP7069R, ASP7070L, ASP7074R, GLN7053R, GLN7061L, GLN7067L, GLU7056R, GLU7065R, GLU7093L, GLU7094L, GLY7038R, GLY7091L, HIS7054R, HIS7072L, HIS7227L, ILE7066L, ILE7073L, LEU7058R, LEU7059R, LEU7062R, LEU7072R, LEU7079R, LEU7101L, LYS7060R, LYS7062L, LYS7099L, LYS7100L, LYS7103L, LYS7228L, LYS7231L, PHE7111L, PHE7229L, PRO7071R, PRO7105L, THR7064R, TYR7068R, TYR7077L, VAL7037R, VAL7063R, VAL7064L, VAL7068L, VAL7069L, VAL7088L
• L-5: ASN6765, ASP6775, ASP7008L, ASP7017L, ASP7675, GLU8135, SER7015L
• B-M: ALA1024B, ALA1027B, ALA1049B, ALA1050B, ALA1054B, ALA1056B, ALA2115M, ALA2133M, ALA2134M, ALA2136M, ARG1029B, ARG1045B, ARG1174B, ASN1028B, ASN1089B, ASN1092B, ASP1032B, ASP1051B, ASP1057B, ASP2120M, GLN1053B, GLN1060B, GLN2081M, GLN2085M, GLN2091M, GLU2139M, GLY2092M, GLY2117M, GLY2122M, HIS2114M, HIS2116M, ILE1026B, ILE1055B, ILE1058B, ILE2113M, LEU1093B, LEU2080M, LEU2087M, LEU2125M, LEU2127M, LEU2132M, LEU2138M, LYS2084M, MET2135M, PHE2088M, SER1048B, SER2112M, SER2118M, SER2126M, SER2131M, SER2140M, THR1020B, THR1022B, THR1031B, THR1052B, THR1094B, THR2119M, TRP2142M, TYR1025B, TYR1061B, TYR2097M, TYR2123M, TYR2124M, VAL1030B, VAL2121M
• B-R: ALA1095B, ALA1125B, ALA1127B, ARG7027R, ARG7057R, ARG7095R, ASN7029R, ASN7100R, ASN7104R, ASP1091B, ASP1139B, ASP7048R, ASP7051R, CYS1086B, GLN702R, GLN703R, GLN7053R, GLU1084B, GLU1088B, GLU7056R, GLY1096B, GLY1116B, GLY1117B, GLY1128B, GLY7020R, GLY7030R, HIS1120B, HIS7054R, ILE1003B, ILE1097B, ILE1098B, ILE1113B, ILE1126B, ILE7049R, ILE7055R, ILE705R, LEU1115B, LEU1122B, LEU7025R, LEU7026R, LEU7058R, LEU7102R, LYS1083B, LYS1090B, LYS1121B, MET7052R, MET7099R, PHE7028R, PRO1114B, PRO704R, PRO7101R, SER1046B, SER1080B, SER1118B, SER1131B, SER7024R, SER7050R, THR1094B, THR1112B, THR1132B, THR701R, THR707R, TRP7103R, TYR1087B, TYR1124B, TYR1135B, TYR7022R, VAL1119B, VAL7031R, VAL706R
• B-D: ALA1162B, ALA1162D, ASN1141B, ASN1141D, ASP1139B, ASP1139D, ASP1153B, ASP1153D, CYS1138B, CYS1138D, GLN1161B, GLN1161D, GLN1195B, GLN1195D, GLU1194B, GLU1194D, GLY1136B, GLY1136D, HIS1157B, HIS1157D, ILE1126B, ILE1126D, ILE1134B, ILE1134D, LEU1159D, LEU1196B, LEU1196D, LYS1140B, LYS1140D, LYS1156B, LYS1156D, LYS1164B, LYS1164D, PHE1133B, PHE1133D, PHE1154B, PHE1154D, SER1131B, SER1131D, SER1158B, SER1158D, SER1160B, SER1160D, THR1132B, THR1132D, TRP1165B, TRP1165D, TYR1124B, TYR1124D, TYR1135B, TYR1135D, TYR1137B, TYR1137D, TYR1193B, TYR1193D
• B-4: ALA1024B, ALA1027B, ALA1049B, ALA1054B, ALA1056B, ALA1162B, ALA71814, ALA72144, ARG1019B, ARG1029B, ARG1036B, ARG1045B, ARG1174B, ARG1185B, ARG70274, ARG71744, ARG71794, ARG71824, ARG71854, ASN1028B, ASN70294, ASN72084, ASP1032B, ASP1039B, ASP1057B, ASP1166B, ASP1191B, ASP71804, ASP72124, ASP72164, CYS1043B, GLN1053B, GLN1060B, GLN1161B, GLN1195B, GLN72054, GLN72234, GLU1184B, GLU1192B, GLU1194B, GLU72074, GLY1023B, GLY1130B, GLY1167B, GLY1170B, GLY1171B, GLY70234, GLY72194, GLY72214, HIS1038B, HIS71414, ILE1026B, ILE1055B, ILE1058B, ILE1163B, ILE1187B, ILE72174, ILE72254, LEU1034B, LEU1178B, LEU1186B, LEU70194, LEU70254, LEU70264, LEU71764, LYS1033B, LYS1164B, LYS72104, LYS72154, LYS72184, LYS72244, MET71424, MET72094, PHE1082B, PHE1133B, PHE1188B, PHE70284, PHE71384, PHE72134, PRO1190B, SER1018B, SER1129B, SER1168B, SER1169B, SER70214, SER70244, SER71834, THR1020B, THR1021B, THR1022B, THR1031B, THR1035B, THR1052B, THR1132B, THR70014, THR72224, TRP1042B, TRP1165B, TRP72114, TYR1025B, TYR1189B, TYR1193B, TYR70224, TYR71774, TYR71784, TYR72204, VAL1030B, VAL1037B, VAL1172B, VAL1176B, VAL1183B, VAL71754, VAL72064
• M-N: ALA2027M, ALA2032M, ALA2049M, ALA2050M, ALA2054M, ALA2096M, ALA2211M, ALA3072N, ALA3124N, ALA3161N, ALA3176N, ARG2188M, ARG2196M, ARG2207M, ARG3090N, ARG3189N, ASN2030M, ASN2189M, ASN2219M, ASN3148N, ASN3164N, ASP2028M, ASP2051M, ASP2222M, ASP3116N, ASP3122N, ASP3126N, ASP3135N, ASP3153N, ASP3184N, CYS2031M, CYS2221M, CYS3120N, CYS3141N, GLN2022M, GLN2057M, GLN3080N, GLN3136N, GLN3160N, GLN3195N, GLU2053M, GLU2215M, GLU3032N, GLU3123N, GLU3142N, GLU3146N, GLU3150N, GLU3152N, GLU3156N, GLU3185N, GLY2092M, GLY2095M, GLY2208M, GLY3038N, GLY3114N, GLY3119N, GLY3131N, GLY3139N, GLY3175N, HIS2035M, HIS2086M, HIS2093M, HIS3036N, HIS3039N, ILE2025M, ILE2094M, ILE2217M, ILE2220M, ILE3103N, ILE3118N, ILE3121N, ILE3128N, ILE3158N, ILE3180N, ILE3181N, LEU2058M, LEU2213M, LEU3018N, LEU3117N, LEU3144N, LEU3149N, LEU3154N, LEU3162N, LEU3163N, LEU3191N, LYS2029M, LYS2199M, LYS2201M, LYS2204M, LYS2214M, LYS3030N, LYS3066N, LYS3125N, LYS3182N, LYS3183N, LYS3188N, LYS3192N, MET3006N, MET3140N, MET3193N, PHE2205M, PHE3041N, PHE3091N, PHE3115N, PHE3127N, PHE3138N, PHE3155N, PRO2024M, PRO2206M, PRO3147N, PRO3151N, SER2020M, SER2202M, SER2216M, SER3083N, SER3084N, SER3130N, SER3134N, SER3143N, SER3159N, THR2048M, THR2052M, THR2209M, THR2210M, THR3157N, TRP3174N, TYR2090M, TYR2203M, TYR3037N, TYR3087N, TYR3145N, TYR3179N, TYR3190N, VAL2026M, VAL2055M, VAL2195M, VAL2212M, VAL2218M, VAL3040N, VAL3129N, VAL3177N, VAL3178N, VAL3186N, VAL3187N
• M-2: GLY52122, ILE52112, LEU2213M, LYS2214M, LYS52012, TRP51982, VAL52102
• M-3: ALA2027M, ALA2133M, ALA2161M, ALA2211M, ALA61323, ALA61333, ALA61823, ARG2019M, ARG2196M, ARG2207M, ARG60193, ARG60293, ARG61763, ARG61853, ARG62123, ASN2030M, ASN2165M, ASN2172M, ASN2194M, ASN60203, ASN60273, ASN6083, ASN61433, ASN61493, ASN61563, ASP2017M, ASP2028M, ASP2166M, ASP60233, ASP6073, ASP61773, ASP61913, ASP62133, GLN2022M, GLN2160M, GLN2200M, GLN61443, GLN61503, GLN61883, GLU2197M, GLU2198M, GLU61523, GLU61693, GLU61703, GLU61843, GLU62093, GLY2023M, GLY2130M, GLY2162M, GLY2168M, GLY2170M, GLY2208M, GLY6093, GLY61543, GLY61573, GLY61903, HIS61863, ILE2025M, ILE2163M, ILE60213, ILE60263, ILE61723, ILE61873, LEU2167M, LEU2213M, LEU61363, LEU61413, LEU61663, LEU61743, LEU62103, LYS2029M, LYS2199M, LYS2201M, LYS2204M, LYS61483, LYS61583, LYS61603, LYS61613, LYS61733, LYS62113, PHE2205M, PHE61403, PHE61473, PHE61793, PRO2024M, PRO2193M, PRO2206M, PRO61533, SER2020M, SER2129M, SER2169M, SER2171M, SER2202M, SER60253, SER61353, SER61783, SER61813, THR2001M, THR2021M, THR2209M, THR2210M, THR60223, THR61553, THR61803, THR61833, TRP2164M, TYR2203M, TYR60243, TYR61513, TYR62083, VAL2026M, VAL2195M, VAL2212M, VAL61453, VAL61593, VAL61713, VAL61753, VAL61893
• M-4: ALA2133M, ALA2134M, ALA2136M, ALA2158M, ALA2161M, ALA71404, ALA71434, ALA71684, ALA71724, ALA72144, ARG2075M, ARG71484, ARG71744, ARG71794, ASN2165M, ASN71444, ASN71714, ASP2120M, ASP2145M, ASP2157M, ASP2166M, ASP71524, ASP71804, ASP72124, ASP72164, GLN2081M, GLN2085M, GLN2144M, GLN2160M, GLN72234, GLU2139M, GLY2117M, GLY2122M, GLY2130M, GLY2162M, GLY71394, GLY72194, GLY72214, HIS2109M, HIS2141M, HIS71414, ILE2113M, ILE72174, LEU2080M, LEU2110M, LEU2125M, LEU2132M, LEU2138M, LEU2154M, LEU2167M, LEU71464, LEU71474, LEU71764, LYS2007M, LYS2084M, LYS2143M, LYS2153M, LYS71494, LYS72104, LYS72154, LYS72184, LYS72244, MET2135M, MET71424, PHE2111M, PHE71384, PHE72134, PRO71454, SER2078M, SER2112M, SER2118M, SER2126M, SER2129M, SER2131M, SER2140M, THR2106M, THR2119M, THR71334, THR72224, TRP2142M, TRP2164M, TRP72114, TYR2123M, TYR2124M, TYR71784, TYR72204, VAL2076M, VAL2077M, VAL2121M, VAL2137M, VAL71754
• N-O: ALA3048N, ALA4088O, ALA4131O, ARG3059N, ARG3089N, ARG4007O, ARG4084O, ARG4092O, ASN3029N, ASN3055N, ASN307N, ASP3050N, ASP4119O, ASP4144O, GLN3023N, GLN4077O, GLN4085O, GLN4117O, GLU3032N, GLU3056N, GLU4126O, GLY3021N, GLY3026N, GLY3092N, GLY4122O, GLY4130O, GLY4133O, GLY4136O, HIS4132O, ILE306N, ILE4091O, ILE4118O, LEU3018N, LEU3020N, LEU3025N, LEU3047N, LEU3054N, LEU3117N, LEU4087O, LEU4102O, LEU4121O, LEU4127O, LYS3030N, LYS4089O, LYS4124O, MET3057N, PHE3031N, PHE3091N, PHE3095N, PHE4082O, PHE4137O, PHE4140O, PRO303N, PRO3093N, PRO4128O, SER3022N, SER3024N, SER3028N, SER4081O, SER4135O, THR3049N, THR3052N, THR3053N, THR4123O, THR4139O, TRP3174N, TYR3094N, TYR4120O, TYR4129O, TYR4134O, TYR4138O, VAL3027N, VAL3051N, VAL3096N, VAL4125O
• N-2: ALA3133N, ALA3165N, ALA3166N, ALA3170N, ALA3176N, ALA50202, ALA50222, ALA50272, ALA51632, ALA51642, ALA51652, ALA51692, ARG3019N, ARG3168N, ARG3194N, ARG50192, ARG51672, ASN3029N, ASN3164N, ASN50242, ASN52082, ASN52092, ASP302N, ASP3135N, ASP3167N, ASP3169N, ASP3196N, ASP50172, ASP51682, ASP51922, GLN3023N, GLN3136N, GLN3195N, GLN50292, GLU51952, GLY3001N, GLY3021N, GLY3026N, GLY308N, GLY3131N, GLY3173N, GLY3175N, GLY50232, GLY51322, GLY51722, GLY51732, GLY51942, GLY52122, HIS51662, HIS51912, ILE306N, ILE52112, LEU3018N, LEU3020N, LEU3025N, LEU3171N, LEU3191N, LEU51622, LEU51962, LYS3030N, LYS3192N, LYS52012, MET3193N, PHE51352, PHE51972, PHE52072, SER3024N, SER3028N, SER304N, SER305N, SER3134N, SER3172N, SER50182, SER50282, SER51312, SER51712, SER51742, THR3132N, THR50212, THR50302, THR51342, TRP3174N, TRP50252, TRP51982, TYR3190N, TYR51702, VAL3027N, VAL50262, VAL51932, VAL52102
• N-3: ALA3124N, ALA3133N, ALA3161N, ALA3165N, ALA3166N, ALA61293, ALA61323, ALA61333, ALA61343, ALA61823, ARG3168N, ARG3194N, ARG61283, ARG61853, ASN3164N, ASN61433, ASN61463, ASN61493, ASN61563, ASP3122N, ASP3126N, ASP3135N, ASP3167N, ASP3169N, ASP61423, ASP61773, CYS3141N, CYS61273, GLN3136N, GLN3160N, GLN61263, GLN61443, GLN61503, GLU3142N, GLU3156N, GLU61253, GLU61843, GLY3139N, GLY61573, HIS61863, ILE3128N, ILE61373, LEU3137N, LEU3144N, LEU3162N, LEU3163N, LEU3191N, LEU61363, LEU61413, LEU61743, LYS3125N, LYS3192N, LYS61483, LYS61583, LYS61603, MET3140N, MET3193N, MET61383, PHE3127N, PHE3138N, PHE61403, PHE61473, PHE61793, PRO61393, PRO61533, SER3134N, SER3143N, SER3159N, SER61353, SER61783, SER61813, THR61803, THR61833, TYR3145N, TYR61513, VAL3129N, VAL61593
• O-P: ALA4019O, ALA4049O, ALA5093P, ARG4022O, ARG4035O, ARG4094O, ARG4095O, ARG5121P, ASN5085P, ASP4029O, ASP4031O, ASP4032O, ASP4051O, ASP5116P, ASP5118P, ASP5125P, ASP5141P, CYS5128P, GLN4054O, GLN4098O, GLN5089P, GLN5133P, GLU4048O, GLU4057O, GLY4023O, GLY4050O, GLY5092P, GLY5119P, GLY5124P, GLY5130P, ILE4024O, ILE5126P, LEU4027O, LEU5122P, LYS4028O, LYS4033O, LYS5081P, LYS5091P, LYS5123P, MET5100P, PHE4055O, PHE5127P, PHE5135P, PRO4096O, SER4025O, SER4030O, SER5084P, SER5117P, SER5131P, THR4021O, THR4052O, THR5120P, THR5134P, TYR4058O, TYR4097O, TYR5088P, TYR5090P, TYR5113P, TYR5114P, TYR5137P, VAL4020O, VAL4026O, VAL4053O, VAL4099O, VAL5087P, VAL5129P
• O-1: ALA40191, ALA4019O, ARG40221, ARG4022O, ARG41701, ARG4170O, ASP40291, ASP4029O, ASP41741, ASP4174O, GLN41651, GLN4165O, GLU41661, GLU4166O, GLU41681, GLU4168O, GLY40231, GLY4023O, ILE40241, ILE4024O, LEU40271, LEU4027O, LEU41671, LEU4167O, LYS40281, LYS4028O, LYS41691, LYS4169O, LYS41761, LYS4176O, MET41711, MET4171O, MET41731, MET4173O, PHE41371, PHE4137O, PHE41751, PHE4175O, PRO41721, PRO4172O, SER40251, SER4025O, SER40301, SER41351, THR40211, THR4021O, TYR41341, TYR4134O, TYR41381, TYR4138O, VAL40201, VAL4020O, VAL40261, VAL4026O
• O-2: ALA4131O, ALA51362, ALA51632, ALA51642, ALA51692, ARG4007O, ARG4148O, ARG4170O, ARG51592, ARG51672, ASN51432, ASN52082, ASN52092, ASP4144O, ASP4150O, ASP51252, ASP51412, ASP51682, CYS4163O, CYS51282, GLN4117O, GLN4165O, GLN51332, GLU4126O, GLU4166O, GLU52032, GLU52042, GLY4130O, GLY4136O, GLY51322, GLY51382, GLY52052, HIS4145O, HIS4146O, HIS51662, ILE51262, LEU4127O, LEU4142O, LEU4143O, LEU4162O, LEU4167O, LEU51402, LEU51562, LEU51622, LYS4169O, LYS52012, MET4171O, PHE4137O, PHE4140O, PHE51272, PHE51352, PHE51972, PHE52072, PRO4128O, PRO4149O, PRO4172O, SER4135O, SER4141O, SER51312, SER51422, SER51602, SER52062, THR4139O, THR51342, TYR4129O, TYR4134O, TYR4138O, TYR4147O, TYR51372, TYR51442, TYR51552, VAL4125O, VAL51392, VAL52002, VAL52102
• P-Q: ALA5020P, ALA5022P, ALA5027P, ALA5049P, ALA5050P, ALA5093P, ALA6129Q, ALA6133Q, ALA6134Q, ARG5033P, ARG6082Q, ARG6092Q, ARG6124Q, ARG6128Q, ASN6146Q, ASN6149Q, ASP5051P, ASP5192P, ASP6117Q, ASP6142Q, CYS5052P, CYS6127Q, GLN5029P, GLN5053P, GLN6085Q, GLN6126Q, GLU5036P, GLU5195P, GLU5202P, GLU6123Q, GLU6125Q, GLY5048P, GLY5060P, GLY5092P, GLY5094P, GLY5173P, GLY5194P, GLY5212P, GLY6090Q, GLY6120Q, GLY6130Q, GLY6131Q, HIS6086Q, HIS6099Q, ILE5035P, ILE5037P, ILE6084Q, ILE6137Q, LEU5086P, LEU5095P, LEU6087Q, LEU6088Q, LEU6136Q, LYS5032P, LYS6148Q, LYS6158Q, LYS6160Q, MET5045P, MET6138Q, PHE5054P, PHE6093Q, PHE6116Q, PHE6140Q, PRO6118Q, PRO6139Q, SER5018P, SER5028P, SER5061P, SER5096P, SER6115Q, SER6121Q, SER6135Q, THR5021P, THR5030P, THR5057P, TRP5025P, TRP5055P, TRP5058P, TRP5198P, TYR5090P, TYR6089Q, TYR6122Q, TYR6151Q, VAL5026P, VAL5031P, VAL5034P, VAL5087P, VAL6119Q
• P-Y: GLY5212P, ILE5211P, LEU2213Y, LYS2214Y, LYS5201P, TRP5198P, VAL5210P
• P-Z: ALA3133Z, ALA3165Z, ALA3166Z, ALA3170Z, ALA3176Z, ALA5020P, ALA5022P, ALA5027P, ALA5163P, ALA5164P, ALA5165P, ALA5169P, ARG3019Z, ARG3168Z, ARG3194Z, ARG5019P, ARG5167P, ASN3029Z, ASN3164Z, ASN5024P, ASN5208P, ASN5209P, ASP302Z, ASP3135Z, ASP3167Z, ASP3169Z, ASP3196Z, ASP5017P, ASP5168P, ASP5192P, GLN3023Z, GLN3136Z, GLN3195Z, GLN5029P, GLU5195P, GLY3001Z, GLY3021Z, GLY3026Z, GLY308Z, GLY3131Z, GLY3173Z, GLY3175Z, GLY5023P, GLY5132P, GLY5172P, GLY5173P, GLY5194P, GLY5212P, HIS5166P, HIS5191P, ILE306Z, ILE5211P, LEU3018Z, LEU3020Z, LEU3025Z, LEU3171Z, LEU3191Z, LEU5162P, LEU5196P, LYS3030Z, LYS3192Z, LYS5201P, MET3193Z, PHE5135P, PHE5197P, PHE5207P, SER3024Z, SER3028Z, SER304Z, SER305Z, SER3134Z, SER3172Z, SER5018P, SER5028P, SER5131P, SER5171P, SER5174P, THR3132Z, THR5001P, THR5021P, THR5030P, THR5134P, TRP3174Z, TRP5025P, TRP5198P, TYR3190Z, TYR5170P, VAL3027Z, VAL5026P, VAL5193P, VAL5210P
• P-1: ALA41311, ALA5136P, ALA5163P, ALA5164P, ALA5169P, ARG40071, ARG41481, ARG41701, ARG5159P, ARG5167P, ASN5143P, ASN5208P, ASN5209P, ASP41441, ASP41501, ASP5125P, ASP5141P, ASP5168P, CYS41631, CYS5128P, GLN41171, GLN41651, GLN5133P, GLU41261, GLU41661, GLU5203P, GLU5204P, GLY41301, GLY41361, GLY5132P, GLY5138P, GLY5205P, HIS41451, HIS41461, HIS5166P, ILE5126P, LEU41271, LEU41421, LEU41431, LEU41591, LEU41621, LEU41671, LEU5140P, LEU5156P, LEU5162P, LYS41691, LYS5201P, MET41711, PHE41371, PHE41401, PHE5127P, PHE5135P, PHE5197P, PHE5207P, PRO41281, PRO41491, PRO41721, SER41351, SER41411, SER5131P, SER5142P, SER5160P, SER5206P, THR41391, THR5134P, TYR41291, TYR41341, TYR41381, TYR41471, TYR5137P, TYR5144P, TYR5155P, VAL41251, VAL5139P, VAL5200P, VAL5210P
• Q-R: ALA6049Q, ALA6050Q, ALA6054Q, ALA7089R, ALA7135R, ALA7140R, ARG6019Q, ARG6029Q, ARG6058Q, ARG6212Q, ARG7095R, ARG7096R, ARG7120R, ARG7148R, ARG7153R, ASN6020Q, ASN6027Q, ASN603Q, ASN608Q, ASN7100R, ASN7104R, ASN7123R, ASN7144R, ASP6023Q, ASP6051Q, ASP6053Q, ASP607Q, ASP6191Q, ASP7152R, ASP7156R, GLN601Q, GLN702R, GLN703R, GLN7094R, GLU6031Q, GLU6209Q, GLU7086R, GLU7154R, GLY6047Q, GLY6052Q, GLY606Q, GLY7126R, GLY7137R, HIS7141R, ILE6021Q, ILE6026Q, LEU6055Q, LEU6210Q, LEU7102R, LEU7124R, LEU7125R, LEU7134R, LYS6057Q, LYS6091Q, LYS7007R, LYS7098R, MET7092R, MET7099R, MET7142R, PHE602Q, PHE6035Q, PHE6048Q, PHE6093Q, PHE6094Q, PHE6207Q, PRO6032Q, PRO604Q, PRO6095Q, PRO704R, PRO7101R, PRO7132R, PRO7145R, SER6025Q, SER6028Q, SER7097R, SER7130R, SER7131R, SER7155R, THR6018Q, THR6022Q, THR701R, THR7090R, THR7128R, THR7133R, TRP7103R, TYR6024Q, TYR6030Q, TYR605Q, TYR6096Q, TYR6097Q, TYR7087R, TYR7093R, TYR7121R, TYR7129R, VAL7122R, VAL7127R, VAL7151R
• Q-Y: ALA2027Y, ALA2133Y, ALA2161Y, ALA2211Y, ALA6132Q, ALA6133Q, ALA6182Q, ARG2019Y, ARG2196Y, ARG2207Y, ARG6019Q, ARG6029Q, ARG6176Q, ARG6185Q, ARG6212Q, ASN2030Y, ASN2165Y, ASN2172Y, ASN2194Y, ASN6020Q, ASN6027Q, ASN608Q, ASN6143Q, ASN6149Q, ASN6156Q, ASP2017Y, ASP2028Y, ASP2166Y, ASP6023Q, ASP6177Q, ASP6191Q, ASP6213Q, GLN2022Y, GLN2160Y, GLN2200Y, GLN6144Q, GLN6150Q, GLN6188Q, GLU2197Y, GLU2198Y, GLU6152Q, GLU6169Q, GLU6170Q, GLU6184Q, GLU6206Q, GLU6209Q, GLY2023Y, GLY2130Y, GLY2162Y, GLY2168Y, GLY2170Y, GLY2208Y, GLY609Q, GLY6154Q, GLY6157Q, GLY6190Q, HIS6186Q, ILE2025Y, ILE2163Y, ILE6021Q, ILE6026Q, ILE6172Q, ILE6187Q, LEU2132Y, LEU2167Y, LEU2213Y, LEU6136Q, LEU6141Q, LEU6166Q, LEU6174Q, LEU6210Q, LYS2029Y, LYS2199Y, LYS2201Y, LYS2204Y, LYS6148Q, LYS6158Q, LYS6160Q, LYS6161Q, LYS6173Q, LYS6211Q, PHE2205Y, PHE6140Q, PHE6147Q, PHE6179Q, PRO2024Y, PRO2193Y, PRO2206Y, PRO6153Q, SER2020Y, SER2129Y, SER2169Y, SER2171Y, SER2202Y, SER6025Q, SER6135Q, SER6178Q, SER6181Q, THR2001Y, THR2021Y, THR2209Y, THR2210Y, THR6022Q, THR6155Q, THR6180Q, THR6183Q, TRP2164Y, TYR2203Y, TYR6024Q, TYR6151Q, TYR6208Q, VAL2026Y, VAL2195Y, VAL2212Y, VAL6145Q, VAL6159Q, VAL6171Q, VAL6175Q, VAL6189Q
• Q-Z: ALA3124Z, ALA3133Z, ALA3161Z, ALA3165Z, ALA3166Z, ALA6129Q, ALA6132Q, ALA6133Q, ALA6134Q, ALA6182Q, ARG3168Z, ARG3194Z, ARG6128Q, ARG6185Q, ASN3164Z, ASN6143Q, ASN6146Q, ASN6149Q, ASN6156Q, ASP3122Z, ASP3126Z, ASP3135Z, ASP3167Z, ASP3169Z, ASP6142Q, ASP6177Q, CYS3141Z, CYS6127Q, GLN3136Z, GLN3160Z, GLN6126Q, GLN6144Q, GLN6150Q, GLU3142Z, GLU3156Z, GLU6125Q, GLU6184Q, GLY3139Z, GLY6157Q, HIS6186Q, ILE3128Z, ILE6137Q, LEU3137Z, LEU3144Z, LEU3162Z, LEU3163Z, LEU3191Z, LEU6136Q, LEU6141Q, LEU6174Q, LYS3125Z, LYS3192Z, LYS6148Q, LYS6158Q, LYS6160Q, MET3140Z, MET3193Z, MET6138Q, PHE3127Z, PHE3138Z, PHE6140Q, PHE6147Q, PHE6179Q, PRO6139Q, PRO6153Q, SER3134Z, SER3143Z, SER3159Z, SER6135Q, SER6178Q, SER6181Q, THR6180Q, THR6183Q, TYR3145Z, TYR6151Q, VAL3129Z, VAL6159Q
• R-C: ARG1077C, ARG1105C, ASP1111C, ASP1231C, GLN7223R, GLU1148C, GLY1109C, GLY7221R, ILE7225R, LYS7224R, THR1078C, THR7222R, TYR1106C, TYR1108C, TYR1110C
• R-D: ALA1024D, ALA1027D, ALA1049D, ALA1054D, ALA1056D, ALA1162D, ALA7181R, ALA7214R, ARG1019D, ARG1029D, ARG1036D, ARG1045D, ARG1174D, ARG1185D, ARG7027R, ARG7174R, ARG7179R, ARG7182R, ARG7185R, ASN1028D, ASN7029R, ASN7208R, ASP1032D, ASP1039D, ASP1051D, ASP1057D, ASP1166D, ASP1191D, ASP7180R, ASP7212R, ASP7216R, CYS1043D, GLN1053D, GLN1060D, GLN1161D, GLN1195D, GLN7205R, GLN7223R, GLU1184D, GLU1192D, GLU1194D, GLU7207R, GLY1023D, GLY1130D, GLY1167D, GLY1170D, GLY1171D, GLY7023R, GLY7219R, GLY7221R, HIS1038D, HIS7141R, ILE1026D, ILE1055D, ILE1058D, ILE1163D, ILE1187D, ILE7217R, ILE7225R, LEU1034D, LEU1178D, LEU1186D, LEU7019R, LEU7025R, LEU7026R, LEU7176R, LYS1033D, LYS1164D, LYS7210R, LYS7215R, LYS7218R, LYS7224R, MET7142R, MET7209R, PHE1082D, PHE1133D, PHE1188D, PHE7028R, PHE7138R, PHE7213R, PRO1190D, SER1018D, SER1129D, SER1168D, SER1169D, SER7021R, SER7024R, SER7183R, THR1020D, THR1021D, THR1022D, THR1031D, THR1035D, THR1052D, THR1132D, THR7001R, THR7222R, TRP1042D, TRP1165D, TRP7211R, TYR1025D, TYR1189D, TYR1193D, TYR7022R, TYR7177R, TYR7178R, TYR7220R, VAL1030D, VAL1037D, VAL1059D, VAL1172D, VAL1176D, VAL1183D, VAL7175R, VAL7206R
• R-Y: ALA2133Y, ALA2134Y, ALA2136Y, ALA2158Y, ALA2161Y, ALA7140R, ALA7143R, ALA7168R, ALA7172R, ALA7214R, ARG2075Y, ARG7148R, ARG7174R, ARG7179R, ASN2165Y, ASN7144R, ASN7171R, ASP2120Y, ASP2145Y, ASP2157Y, ASP2166Y, ASP7152R, ASP7180R, ASP7212R, ASP7216R, GLN2081Y, GLN2085Y, GLN2144Y, GLN2160Y, GLN7223R, GLU2139Y, GLY2117Y, GLY2122Y, GLY2130Y, GLY2162Y, GLY7139R, GLY7219R, GLY7221R, HIS2109Y, HIS2141Y, HIS7141R, ILE2113Y, ILE7217R, LEU2080Y, LEU2110Y, LEU2125Y, LEU2132Y, LEU2138Y, LEU2154Y, LEU2167Y, LEU7146R, LEU7147R, LEU7176R, LYS2007Y, LYS2084Y, LYS2143Y, LYS2153Y, LYS7149R, LYS7210R, LYS7215R, LYS7218R, LYS7224R, MET2135Y, MET7142R, PHE2111Y, PHE7138R, PHE7213R, PRO7145R, SER2078Y, SER2112Y, SER2118Y, SER2126Y, SER2129Y, SER2131Y, SER2140Y, THR2106Y, THR2119Y, THR7133R, THR7222R, TRP2142Y, TRP2164Y, TRP7211R, TYR2123Y, TYR2124Y, TYR7178R, TYR7220R, VAL2076Y, VAL2077Y, VAL2121Y, VAL2137Y, VAL7175R
• C-S: ALA1044C, ALA1118C, ALA1122C, ALA1132C, ALA1160C, ALA1168C, ALA1170C, ALA2024S, ALA2027S, ALA2056S, ALA2121S, ARG1024C, ARG1046C, ARG1120C, ARG1131C, ARG2083S, ARG2090S, ARG2128S, ASN1123C, ASN1181C, ASN1184C, ASP1013C, ASP1115C, ASP1158C, ASP1192C, ASP2022S, ASP2081S, ASP2087S, GLN1126C, GLN1130C, GLN1175C, GLN1176C, GLN2020S, GLN2030S, GLU1022C, GLU1183C, GLU2059S, GLY1023C, GLY1161C, GLY1165C, GLY2079S, GLY2125S, GLY2126S, GLY2131S, HIS1185C, ILE1016C, ILE1018C, ILE1127C, ILE1154C, ILE1178C, ILE1191C, ILE2021S, LEU1025C, LEU1043C, LEU1124C, LEU1150C, LEU1182C, LEU2025S, LEU2055S, LEU2061S, LEU2085S, LYS1107C, LYS1119C, LYS1156C, LYS1167C, LYS1187C, LYS2029S, LYS2049S, LYS2050S, LYS2063S, LYS2088S, LYS2091S, MET1121C, MET1134C, MET2057S, MET2078S, MET2118S, PHE1019C, PHE1186C, PHE2130S, PRO1021C, PRO1152C, PRO1159C, PRO2054S, PRO2080S, PRO2129S, PRO2152S, SER1020C, SER1125C, SER1153C, SER2051S, SER2052S, SER2053S, SER2058S, SER2062S, SER2065S, SER2124S, THR1017C, THR1129C, THR1157C, THR1169C, THR1179C, THR1180C, THR2026S, THR2060S, TYR1012C, TYR1128C, TYR1133C, TYR1155C, TYR1162C, TYR1163C, TYR1166C, TYR2023S, TYR2075S, TYR2082S, VAL1028C, VAL1045C, VAL1164C, VAL2028S, VAL2084S, VAL2086S, VAL2127S, VAL2132S
• C-X: ALA1010C, ALA1031C, ALA1034C, ALA1090C, ALA1093C, ALA1094C, ALA1132C, ALA7112X, ALA7121X, ALA7145X, ALA7162X, ALA7163X, ALA7171X, ALA7173X, ARG1014C, ARG1091C, ARG1096C, ARG1131C, ARG1135C, ARG7019X, ARG7114X, ARG7168X, ASN1036C, ASN1092C, ASN1221C, ASN7011X, ASN7020X, ASN7126X, ASP1013C, ASP1061C, ASP1065C, ASP1089C, ASP7008X, ASP7017X, ASP7113X, ASP7180X, GLN1027C, GLN1037C, GLN7117X, GLN7120X, GLN7169X, GLU1029C, GLU7024X, GLU7151X, GLU7174X, GLU7176X, GLY1011C, GLY1085C, GLY1138C, GLY7004X, GLY7006X, GLY7018X, GLY7038X, GLY7116X, GLY7154X, GLY7158X, GLY7161X, HIS1015C, HIS7122X, HIS7146X, ILE1016C, ILE1040C, ILE1087C, ILE7039X, LEU1063C, LEU1064C, LEU1095C, LEU1137C, LEU7009X, LEU7124X, LEU7147X, LEU7150X, LEU7175X, LEU7178X, LYS1033C, LYS1062C, LYS1098C, LYS7040X, LYS7160X, LYS7172X, LYS7177X, MET1134C, MET7149X, PHE1032C, PHE1073C, PHE7014X, PHE7137X, PRO1060C, PRO1066C, PRO1086C, PRO1088C, PRO1136C, PRO1159C, PRO7016X, PRO7109X, PRO7152X, SER1070C, SER7010X, SER7012X, SER7015X, SER7127X, SER7153X, SER7155X, THR1017C, THR1035C, THR1038C, THR1067C, THR1068C, THR7005X, THR7123X, TRP7157X, TYR1012C, TYR1026C, TYR1030C, TYR1071C, TYR1128C, TYR1133C, TYR7007X, TYR7125X, TYR7148X, TYR7156X, TYR7159X, VAL1028C, VAL1059C, VAL1069C, VAL1139C, VAL7013X, VAL7023X, VAL7119X, VAL7179X
• C-D: ALA1054D, ALA1056D, ALA1094C, ALA1097C, ALA1099C, ALA1101C, ALA1102C, ARG1036D, ARG1077C, ARG1096C, ARG1105C, ASP1039D, ASP1057D, ASP1111C, CYS1074C, GLN1053D, GLN1060D, GLN1069D, GLU1064D, GLU1100C, GLU1103C, GLY1071D, HIS1038D, HIS1062D, ILE1055D, ILE1058D, ILE1075C, ILE1079C, LEU1063D, LEU1065D, LEU1095C, LYS1098C, LYS1107C, LYS1232C, MET1112C, PHE1073C, PHE1104C, SER1068D, SER1076C, THR1067D, THR1072D, THR1078C, TYR1061D, TYR1066D, TYR1070D, TYR1106C, VAL1037D, VAL1059D
• C-Y: ALA1118C, ALA1122C, ALA2079Y, ARG1105C, ARG1120C, ARG2072Y, ARG2075Y, ASN1123C, ASN2062Y, ASP1111C, ASP1115C, ASP1147C, ASP2104Y, CYS1114C, GLN2081Y, GLN2085Y, GLU1100C, GLU1148C, GLU1149C, GLU2073Y, GLY1109C, GLY1151C, HIS2066Y, ILE1079C, ILE2059Y, ILE2063Y, LEU1117C, LEU1124C, LEU1150C, LEU2065Y, LEU2068Y, LEU2080Y, LEU2083Y, LYS1107C, LYS1119C, LYS2084Y, MET1112C, MET1121C, MET2082Y, PHE1104C, PHE2088Y, PRO1113C, PRO2074Y, PRO2105Y, SER1145C, SER1153C, SER2067Y, SER2071Y, SER2078Y, THR2070Y, THR2106Y, TYR1106C, TYR1108C, TYR1110C, TYR1155C, TYR1163C, TYR2069Y, VAL1116C, VAL2076Y, VAL2077Y
• C-7: ARG1014C, ARG1024C, ARG8677, ASP7677, ASP7697, ASP8097, GLU1029C, GLU1177C, GLU1183C, GLU8137, LYS1033C, LYS1174C, LYS8127, LYS8147, LYS8707
• S-T: ALA2115S, ALA2161S, ALA2163S, ALA2171S, ALA3082T, ARG2178S, ARG3050T, ARG3092T, ARG3129T, ASN2143S, ASN2180S, ASN3089T, ASP3060T, ASP3083T, ASP3209T, GLN2119S, GLN2123S, GLN2149S, GLN3059T, GLU2113S, GLU2120S, GLU2176S, GLU3058T, GLU3064T, GLU3085T, GLY2036S, GLY2125S, GLY2154S, GLY3132T, ILE2021S, ILE2037S, ILE2117S, ILE3086T, LEU2109S, LEU2147S, LEU2175S, LEU3056T, LEU3057T, LEU3080T, LEU3128T, LYS2038S, LYS2108S, LYS2116S, LYS2160S, LYS2172S, LYS2177S, LYS3051T, PHE2145S, PHE2157S, PHE2174S, PHE3131T, PRO2158S, PRO3130T, SER2112S, SER2124S, SER2146S, SER2153S, SER2155S, SER3054T, SER3062T, THR2122S, THR2162S, THR2173S, THR3053T, THR3055T, THR3061T, THR3063T, THR3081T, TRP2159S, TRP2179S, TYR2148S, TYR2156S, TYR3067T, TYR3122T, TYR3208T
• S-Y: ALA2093S, ALA2184Y, ARG2036Y, ARG2083S, ARG2090S, ARG2099S, ARG2188Y, ASN2062Y, ASP2087S, ASP2183Y, ASP2220S, ASP2230S, CYS2176Y, GLN2057Y, GLU2064Y, GLU2073Y, GLU2103S, GLU2185Y, GLY2060Y, GLY2102S, GLY2223S, GLY2226S, HIS2035Y, HIS2066Y, HIS2094S, ILE2037Y, ILE2041Y, ILE2059Y, ILE2063Y, ILE2100S, ILE2227S, LEU2034Y, LEU2058Y, LEU2065Y, LEU2066S, LEU2067S, LEU2068Y, LEU2187Y, LEU2221S, LEU2222S, LYS2040Y, LYS2088S, LYS2091S, LYS2098S, LYS2182Y, MET2082Y, MET2178Y, PRO2039Y, PRO2069S, PRO2219S, PRO2228S, PRO2233S, SER2038Y, SER2061Y, SER2062S, SER2065S, SER2067Y, SER2071Y, SER2089S, THR2056Y, THR2060S, THR2068S, THR2070Y, THR2095S, THR2225S, THR2229S, TRP2042Y, TYR2069Y, TYR2101S, TYR2104S, TYR2186Y, TYR2224S, VAL2084S, VAL2086S, VAL2092S, VAL2103Y, VAL2175Y, VAL2177Y
• S-Z: ALA3072Z, ARG2099S, ARG3071Z, ASN2143S, ASN3104Z, ASP2140S, GLN3080Z, GLU2103S, GLU2113S, GLU2141S, GLU3069Z, GLU3070Z, GLU3074Z, GLU3076Z, GLU3088Z, GLU3123Z, GLY2102S, GLY2144S, HIS3039Z, ILE2100S, ILE3073Z, ILE3121Z, LEU2109S, LEU3064Z, LEU3067Z, LEU3081Z, LYS2098S, LYS2108S, LYS3061Z, LYS3068Z, LYS3106Z, LYS3109Z, PHE2142S, PHE3058Z, PHE3078Z, PRO2105S, PRO2106S, PRO3075Z, SER2096S, SER2112S, SER3083Z, SER3084Z, SER3085Z, SER3105Z, SER3107Z, THR2229S, THR3062Z, THR3077Z, THR3079Z, TYR2097S, TYR2101S, TYR2104S, TYR3065Z, VAL3082Z
• S-7: ARG10037, ARG8597, GLU10077, GLU2201S, GLU2203S, GLU8637, HIS10047, LYS2050S, LYS2197S
• S-8: GLU11958, LYS2177S
• T-U: ALA3040T, ALA3162T, ALA3172T, ALA4023U, ALA4026U, ALA4080U, ARG3018T, ARG3113T, ARG3114T, ARG3143T, ARG4029U, ARG4048U, ARG4058U, ARG4083U, ARG4090U, ARG4127U, ASN3152T, ASN3156T, ASN4079U, ASP3117T, ASP3179T, ASP3182T, ASP4056U, ASP4081U, GLN3120T, GLN3124T, GLN3147T, GLN3173T, GLN3177T, GLN4019U, GLN4055U, GLN4117U, GLU3016T, GLU3023T, GLU3109T, GLU4021U, GLU4025U, GLU4087U, GLY3017T, GLY3037T, GLY3121T, GLY3126T, GLY3127T, GLY3145T, GLY3155T, GLY3159T, GLY4077U, GLY4124U, GLY4125U, GLY4130U, HIS3125T, ILE3038T, ILE3044T, ILE3118T, ILE3163T, ILE4059U, ILE4084U, ILE4086U, LEU3019T, LEU3115T, LEU3128T, LEU3148T, LEU3175T, LEU3176T, LEU3192T, LEU4024U, LEU4052U, LEU4054U, LEU4078U, LEU4085U, LYS3119T, LYS3161T, LYS3181T, LYS4028U, LYS4053U, LYS4088U, MET3039T, MET3178T, PHE4075U, PHE4129U, PRO3015T, PRO3153T, PRO4061U, PRO4128U, SER3014T, SER3041T, SER3116T, SER3151T, SER3154T, SER3164T, SER4062U, SER4082U, THR3123T, THR3150T, THR3158T, THR3174T, THR4051U, THR4057U, THR4060U, TRP3160T, TYR3020T, TYR3122T, TYR3144T, TYR3146T, TYR3149T, TYR3157T, TYR3180T, TYR4022U, TYR4120U, VAL3022T, VAL3108T, VAL3112T, VAL4027U, VAL4116U, VAL4126U, VAL4131U
• T-Y: ALA3220T, ASN2219Y, ASP2222Y, ASP3071T, CYS2221Y, GLN3227T, GLU3224T, LYS3068T, LYS3072T, TYR3226T, VAL3225T
• T-Z: ALA3091T, ALA3095T, ARG3059Z, ARG3092T, ASN3055Z, ASN3063Z, ASN3070T, ASN3089T, ASN3097T, ASN3103T, ASP3071T, ASP3105T, GLN3096T, GLN3227T, GLU3056Z, GLU3069Z, GLU3070Z, GLU3104T, HIS3094T, ILE3073T, ILE3088T, ILE3093T, ILE3229T, LEU3054Z, LEU3064Z, LEU3067Z, LEU3069T, LEU3099T, LYS3061Z, LYS3066Z, LYS3068T, LYS3068Z, LYS3072T, LYS3100T, MET3057Z, PHE3058Z, SER3062T, THR3052Z, THR3053Z, THR3061T, THR3062Z, THR3063T, THR3090T, THR3101T, TYR3060Z, TYR3065Z, TYR3067T, TYR3094Z, TYR3098T, TYR3102T
• T-1: ALA40781, ALA40881, ARG3113T, ARG3143T, ARG40691, ARG40841, ASN3097T, ASN3103T, ASN40621, ASP3105T, ASP3141T, ASP3142T, ASP40711, ASP41071, GLN40771, GLN40851, GLU3104T, GLU3109T, GLU40701, GLU40731, GLU40861, GLY3145T, HIS3094T, ILE3106T, ILE3110T, ILE40631, LEU3099T, LEU3111T, LEU40741, LYS3100T, LYS40891, LYS41091, LYS41101, LYS41241, PHE40821, PRO3107T, PRO40761, SER40671, SER40751, SER40801, SER40811, THR3101T, TYR3098T, TYR3102T, TYR3140T, TYR3144T, TYR3157T, TYR40661, TYR40721, TYR41161, VAL40791, VAL40831
• T-8: ASP13838, ASP3179T, ASP3202T, ASP3209T, GLU13758, GLU14978, HIS14958, LYS14948, LYS3199T
• U-V: ALA4114U, ALA4161U, ALA5083V, ALA5085V, ARG4111U, ARG4119U, ARG4172U, ARG4181U, ARG5086V, ARG5093V, ARG5136V, ASN4178U, ASN5215V, ASP4180U, ASP5062V, ASP5084V, GLN4118U, GLN4122U, GLN4149U, GLN4162U, GLN5023V, GLU4021U, GLU4107U, GLU4151U, GLU4173U, GLU4176U, GLU5060V, GLU5065V, GLU5090V, GLU5125V, GLY4035U, GLY4115U, GLY4124U, GLY4125U, GLY4154U, GLY5080V, GLY5139V, ILE4017U, ILE4155U, ILE5064V, LEU4147U, LEU4175U, LEU5058V, LEU5059V, LEU5081V, LEU5133V, LYS4037U, LYS4146U, LYS4177U, MET5088V, MET5134V, PHE4174U, PHE5138V, PRO4145U, PRO5057V, PRO5137V, SER4123U, SER4153U, SER4157U, SER4158U, SER4160U, SER5056V, SER5061V, SER5063V, SER5087V, SER5135V, THR4121U, THR4163U, THR5055V, THR5082V, TRP4159U, TYR4148U, TYR4156U, TYR4179U, VAL4020U, VAL4036U, VAL4126U, VAL4171U, VAL5012V
• U-1: ALA40561, ALA40611, ALA4089U, ALA4093U, ARG40351, ARG40691, ARG4090U, ARG4097U, ASN40621, ASP4068U, ASP40711, GLN40541, GLN40601, GLN40641, GLN4094U, GLU40571, GLU40701, GLU4087U, GLU4092U, GLU4101U, HIS4070U, HIS4096U, ILE40591, ILE40631, ILE4067U, ILE40681, ILE4086U, ILE4221U, LEU40651, LEU4098U, LYS4066U, LYS4088U, PHE40551, SER4062U, SER4065U, SER40671, SER4069U, SER4095U, THR4099U, TYR40581, TYR40661, TYR40971, VAL40531, VAL4071U, VAL4091U
• U-2: ALA50772, ALA50782, ALA50792, ARG4097U, ARG4111U, ARG4141U, ARG50692, ARG51062, ARG51212, ASN50852, ASP4102U, ASP4139U, ASP4142U, CYS50632, GLN50622, GLU4101U, GLU4107U, GLU50702, GLU50722, GLU51082, GLY51092, HIS4096U, HIS50662, ILE50742, ILE50822, LEU4098U, LEU4100U, LEU4109U, LEU50682, LEU50832, LYS50712, LYS50812, LYS51072, LYS51232, PRO4140U, SER50752, SER50802, SER50842, THR4099U, THR4105U, THR51052, THR51112, TYR4108U, TYR4148U, TYR4156U, TYR51132, VAL4104U, VAL50762
• U-8: ARG17988, ARG4049U, ARG4166U, ASP16668, ASP16678, ASP17158, ASP17958, GLN17608, GLN4204U, GLU16238, GLU17118, GLU17188, GLU17538, GLU4173U, GLU4176U, GLU4201U, GLU4237U, HIS17148, HIS17598, LYS16688, LYS18738, LYS4053U, LYS4169U, LYS4177U, LYS4208U, LYS4240U
• V-W: ALA5041V, ALA5127V, ALA5169V, ALA5171V, ALA5179V, ALA5181V, ALA6025W, ALA6028W, ALA6053W, ALA6078W, ALA6081W, ARG5005V, ARG5020V, ARG5122V, ARG5132V, ARG5166V, ARG6003W, ARG6051W, ARG6082W, ARG6089W, ARG6126W, ASN5168V, ASN5185V, ASN6004W, ASN6005W, ASN6052W, ASN6086W, ASN6119W, ASP5118V, ASP6007W, ASP6009W, ASP6054W, ASP6080W, CYS5117V, GLN5114V, GLN5180V, GLN6021W, GLN6031W, GLN6060W, GLN6090W, GLN6121W, GLU5007V, GLU5018V, GLU5025V, GLU5110V, GLU5125V, GLU5130V, GLU5182V, GLU5186V, GLU6023W, GLU6027W, GLU6055W, GLY5011V, GLY5019V, GLY5039V, GLY5124V, GLY5126V, GLY5129V, GLY5162V, GLY6008W, GLY6076W, GLY6124W, GLY6125W, GLY6129W, HIS5157V, HIS5188V, ILE5040V, ILE6029W, ILE6064W, LEU5021V, LEU5119V, LEU5121V, LEU5155V, LEU5183V, LEU5184V, LEU5199V, LEU6026W, LEU6056W, LEU6074W, LEU6077W, LYS5170V, LYS6030W, LYS6050W, LYS6061W, LYS6115W, LYS6118W, MET6001W, PHE5015V, PHE5123V, PHE5156V, PHE5164V, PHE6002W, PHE6020W, PRO5017V, PRO6079W, PRO6127W, PRO6149W, SER5006V, SER5013V, SER5016V, SER5111V, SER5115V, SER5128V, SER5161V, SER6057W, SER6058W, SER6122W, THR5014V, THR5163V, THR6010W, THR6120W, TRP5187V, TYR5008V, TYR5165V, TYR5167V, TYR6024W, TYR6059W, TYR6087W, TYR6123W, TYR6128W, VAL5012V, VAL5024V, VAL6022W, VAL6083W, VAL6130W
• V-2: ALA5092V, ALA5095V, ALA5096V, ARG50642, ARG50692, ARG5072V, ARG5086V, ARG5093V, ASN5100V, ASP5062V, ASP5071V, ASP5104V, ASP5106V, CYS50632, GLN50532, GLN50622, GLU50562, GLU5065V, GLU50672, GLU5069V, GLU50702, GLU5090V, GLY50602, HIS50662, HIS5073V, HIS5091V, ILE5067V, ILE5070V, ILE5074V, ILE5089V, ILE5230V, LEU50592, LEU50652, LEU50682, LEU5101V, LYS50712, PHE50542, PHE5228V, PRO50392, SER50612, SER5063V, THR50572, THR5094V, THR5098V, TRP50552, TRP50582, TYR5102V, VAL5068V, VAL5097V
• V-3: ALA5095V, ALA5096V, ALA5149V, ALA60803, ALA60813, ARG60823, ASN5100V, ASN5108V, ASN60713, ASN60783, ASN60833, ASP5104V, ASP5106V, ASP5148V, ASP5150V, ASP5151V, ASP60693, GLN5114V, GLN60853, GLU5105V, GLU5110V, GLU61073, GLY60903, HIS5099V, HIS60673, HIS60703, HIS60863, ILE5107V, ILE60773, ILE60843, LEU5101V, LEU5112V, LEU60753, LEU60873, LYS60733, LYS60743, PHE60593, PHE60683, SER5111V, SER5115V, SER60623, SER60763, SER60793, THR5098V, TRP60653, TYR5102V, TYR5103V, TYR60663, TYR60893, TYR61143, TYR61223, VAL5097V, VAL5109V, VAL60633
• V-7: ARG5005V, GLU5007V, HIS5237, LYS5897
• V-8: ARG21398, ARG5005V, ARG5020V, ARG5053V, ASP19198, ASP21168, ASP5009V, ASP5213V, GLU20058, GLU5007V, GLU5018V, GLU5025V, GLU5051V, GLU5159V, GLU5177V, GLU5209V, GLU5210V, HIS19178, LYS19188, LYS21118, LYS21128, LYS5211V, SER21088, TYR20748
• W-X: ALA6116W, ALA6142W, ALA6160W, ALA6168W, ALA7026X, ALA7029X, ARG6018W, ARG6039W, ARG6107W, ARG6174W, ARG7085X, ARG7092X, ARG7129X, ASN6005W, ASN6119W, ASN6152W, ASN7011X, ASN7032X, ASN7063X, ASN7089X, ASN7126X, ASP6007W, ASP6009W, ASP6114W, ASP6138W, ASP6177W, ASP7008X, ASP7083X, CYS6113W, GLN6117W, GLN6121W, GLN6148W, GLN7022X, GLN7067X, GLU6106W, GLU6146W, GLU6155W, GLU6173W, GLU7024X, GLU7031X, GLU7093X, GLY6008W, GLY6017W, GLY6037W, GLY6109W, GLY6124W, GLY6141W, GLY6151W, GLY6158W, GLY7006X, GLY7079X, GLY7084X, GLY7132X, HIS6110W, HIS6143W, HIS7086X, HIS7122X, ILE6180W, ILE7053X, ILE7081X, LEU6019W, LEU6038W, LEU6111W, LEU6112W, LEU6144W, LEU6145W, LEU6156W, LEU6172W, LEU6176W, LEU7009X, LEU7052X, LEU7057X, LEU7058X, LEU7080X, LEU7087X, LYS6115W, LYS6118W, LYS6169W, LYS7028X, LYS7051X, LYS7056X, LYS7062X, LYS7065X, LYS7209X, PHE6013W, PHE6179W, PHE7021X, PHE7131X, PRO6015W, PRO6149W, PRO7060X, PRO7082X, PRO7130X, PRO7152X, SER6014W, SER6122W, SER6140W, SER6150W, SER7010X, SER7012X, SER7055X, SER7127X, THR6010W, THR6012W, THR6016W, THR6120W, THR6154W, THR6159W, THR6170W, THR6175W, THR7054X, TYR6006W, TYR6123W, TYR6157W, TYR6171W, TYR7007X, TYR7025X, TYR7118X, TYR7125X, VAL6011W, VAL6022W, VAL6105W, VAL6153W, VAL7023X, VAL7027X, VAL7030X, VAL7059X, VAL7064X, VAL7088X, VAL7128X, VAL7133X
• W-3: ARG60583, ARG6082W, ARG6089W, ASN60613, ASN60713, ASN6086W, ASN6093W, ASN6100W, ASP6067W, ASP60693, ASP60723, CYS6066W, CYS6092W, GLN6090W, GLN6091W, GLU6068W, HIS60673, HIS6069W, HIS60703, ILE6064W, ILE6224W, LEU6088W, LEU6097W, LEU6103W, LYS60573, LYS60603, LYS6061W, LYS60643, LYS6065W, LYS6102W, MET6070W, PHE60683, PHE6099W, SER60623, SER6085W, SER6096W, TRP60653, TYR6087W, TYR6094W, VAL6098W
• W-4: ALA6104W, ALA70674, ALA70734, ALA70754, ALA70784, ALA70894, ARG6101W, ARG6107W, ASN6100W, ASN70664, ASN70704, ASN71144, ASP6114W, ASP6138W, ASP70694, GLN70944, GLN71124, GLU6106W, GLU70654, GLU70764, GLU70774, GLU70804, GLU70864, GLY6141W, HIS6069W, HIS6110W, HIS6143W, ILE70844, LEU6097W, LEU6103W, LEU6111W, LEU70584, LEU70594, LEU70624, LEU70724, LEU70794, LEU70884, LYS6102W, LYS6139W, PHE6099W, PHE70854, PHE71184, PRO70714, PRO70814, SER6095W, SER6096W, SER6140W, SER70824, SER71134, THR70904, TYR6094W, TYR70684, TYR70834, TYR70874, VAL6098W, VAL6105W, VAL70914
• W-7: ARG6003W, ARG6357, ARG6377, ASN6005W, GLN5877, HIS6367, LYS5897, MET6001W, SER6347
• W-8: ALA21438, ALA6078W, ARG20488, ARG20948, ARG6003W, ARG6164W, ARG6202W, ASP21168, ASP21328, ASP6203W, GLN20498, GLN6031W, GLU20478, GLU21318, GLU21348, GLU6027W, GLU6055W, GLU6204W, GLY6076W, LYS20538, LYS21118, LYS6030W, LYS6062W, PHE6002W, TYR21418
• X-D: ALA1078D, ALA1079D, ALA7110X, ARG7114X, ASN1106D, ASN7143X, ASP1103D, ASP7113X, GLN1069D, GLN7117X, GLU1076D, GLU1084D, GLU1088D, GLU7094X, GLY1071D, HIS1062D, ILE1058D, ILE7106X, LEU1063D, LEU1065D, LEU1085D, LEU7101X, LYS1083D, LYS1105D, LYS7099X, LYS7100X, LYS7103X, LYS7142X, PHE1082D, PHE7098X, PHE7111X, PRO1073D, PRO7105X, PRO7107X, PRO7109X, SER1074D, SER1080D, SER7097X, THR1072D, THR1075D, THR1077D, THR7104X, TYR1066D, TYR1070D, TYR1087D, TYR1111D, TYR7102X, VAL1059D, VAL1081D, VAL1119D
• X-4: ALA70674, ALA70734, ALA70754, ALA7095X, ALA7096X, ARG70574, ARG7071X, ARG7085X, ARG7092X, ASN7063X, ASN70664, ASN70704, ASN7089X, ASP70614, ASP70694, ASP7070X, ASP70744, GLN70534, GLN7061X, GLN7067X, GLU70564, GLU70654, GLU7093X, GLU7094X, GLY70384, GLY7091X, HIS70544, HIS7072X, HIS7227X, ILE7066X, ILE7073X, LEU70584, LEU70594, LEU70624, LEU70724, LEU70794, LEU7101X, LYS70604, LYS7062X, LYS7099X, LYS7100X, LYS7103X, LYS7228X, LYS7231X, PHE7111X, PHE7229X, PRO70714, PRO7105X, THR70644, TYR70684, TYR7077X, VAL70374, VAL70634, VAL7064X, VAL7068X, VAL7069X, VAL7088X
• X-7: ASN6767, ASP6777, ASP7008X, ASP7017X, GLU8137, SER7015X
• D-Y: ALA1024D, ALA1027D, ALA1049D, ALA1050D, ALA1054D, ALA1056D, ALA2115Y, ALA2133Y, ALA2134Y, ALA2136Y, ARG1029D, ARG1045D, ARG1174D, ASN1028D, ASN1089D, ASN1092D, ASP1032D, ASP1051D, ASP1057D, ASP2120Y, GLN1053D, GLN1060D, GLN2081Y, GLN2085Y, GLN2091Y, GLU2139Y, GLY2092Y, GLY2117Y, GLY2122Y, HIS2114Y, HIS2116Y, ILE1026D, ILE1055D, ILE1058D, ILE2113Y, LEU1093D, LEU2080Y, LEU2087Y, LEU2125Y, LEU2127Y, LEU2132Y, LEU2138Y, LYS2084Y, MET2135Y, PHE2088Y, SER1048D, SER2112Y, SER2118Y, SER2126Y, SER2131Y, SER2140Y, THR1020D, THR1022D, THR1031D, THR1052D, THR1094D, THR2119Y, TRP2142Y, TYR1025D, TYR1061D, TYR2097Y, TYR2123Y, TYR2124Y, VAL1030D, VAL2121Y
• D-4: ALA1095D, ALA1125D, ALA1127D, ARG70274, ARG70574, ARG70954, ASN70294, ASN71004, ASN71044, ASP1091D, ASP1139D, ASP70484, ASP70514, CYS1086D, GLN7024, GLN7034, GLN70534, GLU1084D, GLU1088D, GLU70564, GLY1096D, GLY1116D, GLY1117D, GLY1128D, GLY70204, GLY70304, HIS1120D, HIS70544, ILE1003D, ILE1097D, ILE1098D, ILE1113D, ILE1126D, ILE70494, ILE7054, ILE70554, LEU1115D, LEU1122D, LEU70254, LEU70264, LEU70584, LEU71024, LYS1083D, LYS1090D, LYS1121D, MET70524, MET70994, PHE70284, PRO1114D, PRO7044, PRO71014, SER1046D, SER1080D, SER1118D, SER1131D, SER70244, SER70504, THR1094D, THR1112D, THR1132D, THR7014, TRP71034, TYR1087D, TYR1124D, TYR1135D, TYR70224, VAL1119D, VAL70314, VAL7064
• Y-Z: ALA2027Y, ALA2032Y, ALA2049Y, ALA2050Y, ALA2054Y, ALA2096Y, ALA2211Y, ALA3072Z, ALA3124Z, ALA3161Z, ALA3176Z, ARG2188Y, ARG2196Y, ARG2207Y, ARG3090Z, ARG3189Z, ASN2030Y, ASN2189Y, ASN2219Y, ASN3148Z, ASN3164Z, ASP2028Y, ASP2051Y, ASP2222Y, ASP3116Z, ASP3122Z, ASP3126Z, ASP3135Z, ASP3153Z, ASP3184Z, CYS2031Y, CYS2221Y, CYS3120Z, CYS3141Z, GLN2022Y, GLN2057Y, GLN3080Z, GLN3136Z, GLN3160Z, GLN3195Z, GLU2053Y, GLU2215Y, GLU3032Z, GLU3123Z, GLU3142Z, GLU3146Z, GLU3150Z, GLU3152Z, GLU3156Z, GLU3185Z, GLY2092Y, GLY2095Y, GLY2208Y, GLY3038Z, GLY3114Z, GLY3119Z, GLY3131Z, GLY3139Z, GLY3175Z, HIS2035Y, HIS2086Y, HIS2093Y, HIS3036Z, HIS3039Z, ILE2025Y, ILE2094Y, ILE2217Y, ILE2220Y, ILE3103Z, ILE3118Z, ILE3121Z, ILE3128Z, ILE3158Z, ILE3180Z, ILE3181Z, LEU2058Y, LEU2213Y, LEU3018Z, LEU3117Z, LEU3144Z, LEU3149Z, LEU3154Z, LEU3162Z, LEU3163Z, LEU3191Z, LYS2029Y, LYS2199Y, LYS2201Y, LYS2204Y, LYS2214Y, LYS3030Z, LYS3066Z, LYS3125Z, LYS3182Z, LYS3183Z, LYS3188Z, LYS3192Z, MET3006Z, MET3140Z, MET3193Z, PHE2205Y, PHE3041Z, PHE3091Z, PHE3115Z, PHE3127Z, PHE3138Z, PHE3155Z, PRO2024Y, PRO2206Y, PRO3147Z, PRO3151Z, SER2020Y, SER2202Y, SER2216Y, SER3083Z, SER3084Z, SER3130Z, SER3134Z, SER3143Z, SER3159Z, THR2048Y, THR2052Y, THR2209Y, THR2210Y, THR3157Z, TRP3174Z, TYR2090Y, TYR2203Y, TYR3037Z, TYR3087Z, TYR3145Z, TYR3179Z, TYR3190Z, VAL2026Y, VAL2055Y, VAL2195Y, VAL2212Y, VAL2218Y, VAL3040Z, VAL3129Z, VAL3177Z, VAL3178Z, VAL3186Z, VAL3187Z
• Z-1: ALA3048Z, ALA40881, ALA41311, ARG3059Z, ARG3089Z, ARG40071, ARG40841, ARG40921, ASN3029Z, ASN3055Z, ASN307Z, ASP3050Z, ASP41191, ASP41441, GLN3023Z, GLN40771, GLN40851, GLN41171, GLU3032Z, GLU3056Z, GLU41261, GLY3021Z, GLY3026Z, GLY3092Z, GLY41221, GLY41301, GLY41331, GLY41361, HIS41321, ILE306Z, ILE40911, ILE41181, LEU3018Z, LEU3020Z, LEU3025Z, LEU3047Z, LEU3054Z, LEU3117Z, LEU40871, LEU41021, LEU41211, LEU41271, LYS3030Z, LYS40891, LYS41241, MET3057Z, PHE3031Z, PHE3091Z, PHE3095Z, PHE41371, PHE41401, PRO303Z, PRO3093Z, PRO41281, SER3022Z, SER3024Z, SER3028Z, SER40811, SER41351, THR3049Z, THR3052Z, THR3053Z, THR41231, THR41391, TRP3174Z, TYR3094Z, TYR41201, TYR41291, TYR41341, TYR41381, VAL3027Z, VAL3051Z, VAL3096Z, VAL41251
• 1-2: ALA40191, ALA40491, ALA50932, ARG40221, ARG40351, ARG40941, ARG40951, ARG51212, ASN50852, ASP40291, ASP40311, ASP40321, ASP40511, ASP51162, ASP51182, ASP51252, ASP51412, CYS51282, GLN40541, GLN40981, GLN50892, GLN51332, GLU40481, GLU40571, GLY40231, GLY40501, GLY50922, GLY51192, GLY51242, GLY51302, ILE40241, ILE51262, LEU40271, LEU51222, LYS40281, LYS40331, LYS50812, LYS50912, LYS51232, MET51002, PHE40551, PHE51272, PHE51352, PRO40961, SER40251, SER40301, SER50842, SER51172, SER51312, THR40211, THR40521, THR51202, THR51342, TYR40581, TYR40971, TYR50882, TYR50902, TYR51132, TYR51142, TYR51372, VAL40201, VAL40261, VAL40531, VAL40991, VAL50872, VAL51292
• 2-3: ALA50202, ALA50222, ALA50272, ALA50492, ALA50502, ALA50932, ALA61293, ALA61333, ALA61343, ARG50332, ARG60823, ARG60923, ARG61243, ARG61283, ASN61463, ASN61493, ASP50512, ASP51922, ASP61173, ASP61423, CYS50522, CYS61273, GLN50292, GLN50532, GLN60853, GLN61263, GLU50362, GLU51952, GLU52022, GLU61233, GLU61253, GLY50482, GLY50602, GLY50922, GLY50942, GLY51732, GLY51942, GLY52122, GLY60903, GLY61203, GLY61303, GLY61313, HIS60863, HIS60993, ILE50352, ILE50372, ILE60843, ILE61373, LEU50862, LEU50952, LEU60873, LEU60883, LEU61363, LYS50322, LYS61483, LYS61583, LYS61603, MET50452, MET61383, PHE50542, PHE60933, PHE61163, PHE61403, PRO61183, PRO61393, SER50182, SER50282, SER50612, SER50962, SER61153, SER61213, SER61353, THR50212, THR50302, THR50572, TRP50252, TRP50552, TRP50582, TRP51982, TYR50902, TYR60893, TYR61223, TYR61513, VAL50262, VAL50312, VAL50342, VAL50872, VAL61193
• 3-4: ALA60493, ALA60503, ALA60543, ALA70894, ALA71354, ALA71404, ARG60193, ARG60293, ARG60583, ARG62123, ARG70954, ARG70964, ARG71204, ARG71484, ARG71534, ASN60203, ASN60273, ASN6033, ASN6083, ASN71004, ASN71044, ASN71234, ASN71444, ASP60233, ASP60513, ASP60533, ASP6073, ASP61913, ASP71524, ASP71564, GLN6013, GLN7024, GLN7034, GLN70944, GLU60313, GLU62093, GLU70864, GLU71544, GLY60473, GLY60523, GLY6063, GLY71264, GLY71374, HIS71414, ILE60213, ILE60263, LEU60553, LEU62103, LEU71024, LEU71244, LEU71254, LEU71344, LYS60573, LYS60913, LYS70074, LYS70984, MET70924, MET70994, PHE6023, PHE60353, PHE60483, PHE60933, PHE60943, PHE62073, PHE70854, PRO60323, PRO6043, PRO60953, PRO7044, PRO71014, PRO71324, PRO71454, SER60253, SER60283, SER70974, SER71304, SER71314, SER71554, THR60183, THR60223, THR7014, THR70904, THR71284, THR71334, TRP71034, TYR60243, TYR60303, TYR6053, TYR60963, TYR60973, TYR70874, TYR70934, TYR71214, TYR71294, VAL71224, VAL71274, VAL71514
• E-5: ALA137E, ALA150E, ALA2585, ARG110E, ARG114E, ARG117E, ARG2605, ARG2975, ARG9595, ASN103E, ASN146E, ASN2395, ASN2415, ASN2455, ASN2495, ASP135E, ASP2545, ASP2945, ASP2955, ASP2965, ASP92E, CYS141E, CYS2505, GLN136E, GLN2765, GLU119E, GLU123E, GLU124E, GLU131E, GLU2465, HIS100E, HIS133E, HIS142E, HIS2425, HIS2525, HIS2835, HIS88E, ILE104E, ILE122E, ILE149E, ILE151E, LEU140E, LEU144E, LEU147E, LEU154E, LEU2475, LEU2515, LEU2595, LEU2635, LEU2705, LEU2905, LEU86E, LEU91E, LYS2485, LYS2775, LYS9625, MET101E, MET2865, PHE112E, PHE120E, PHE2535, PHE2555, PRO107E, PRO118E, PRO121E, PRO2565, SER109E, SER113E, SER115E, SER132E, SER152E, SER153E, SER2625, SER2925, THR130E, THR2445, THR2985, THR90E, TRP111E, TRP2435, TYR105E, TYR139E, TYR148E, TYR2675, TYR2695, TYR89E, TYR93E, VAL116E, VAL143E, VAL145E, VAL2405, VAL2575, VAL2665, VAL2735
• E-6: ARG12636, ARG85E, ASP11486, ASP135E, ASP14146, GLU119E, GLU123E, GLU12456, GLU131E, GLU84E, HIS88E
• 5-6: ALA15266, ARG10035, ARG11746, ARG11786, ARG12496, ARG12636, ARG12716, ARG18286, ARG3335, ARG4805, ARG6505, ARG8835, ARG9365, ARG9595, ASN11716, ASN11936, ASN5265, ASP10315, ASP10335, ASP11486, ASP12146, ASP15186, ASP15656, ASP18306, ASP18326, ASP2965, ASP3285, ASP3305, ASP4065, ASP4655, ASP4665, ASP9345, GLN2745, GLU12186, GLU12456, GLU20236, GLU5095, GLU5195, GLU6065, GLU7875, GLU9315, GLU9855, GLU9895, GLU9965, GLY18356, HIS10215, HIS11736, HIS12066, HIS12426, HIS12606, HIS12676, HIS20196, HIS2525, HIS5465, HIS9215, HIS9645, LYS10365, LYS11636, LYS11856, LYS12726, LYS13946, LYS16866, LYS19426, LYS20226, LYS2775, LYS5165, LYS5435, LYS9435, PRO12466, SER19766, TYR11696, TYR20746, TYR4125, VAL14016
• F-7: ARG114F, ARG2977, ARG9597, ASP2547, ASP2957, ASP2967, GLU119F, GLU123F, GLU124F, HIS100F, HIS2527, LYS9627, PHE112F, THR2987, VAL116F, VAL2577
• F-8: ARG12638, ARG85F, ASP11488, ASP135F, ASP14148, GLU119F, GLU123F, GLU12458, GLU131F, GLU84F, HIS88F
• 7-8: ALA15268, ARG10037, ARG11748, ARG11788, ARG12498, ARG12638, ARG12718, ARG18288, ARG3337, ARG4807, ARG6507, ARG8837, ARG9367, ARG9597, ASN11718, ASN11938, ASN5267, ASP10317, ASP10337, ASP11488, ASP12148, ASP15188, ASP15658, ASP18308, ASP18328, ASP2967, ASP3287, ASP3307, ASP4067, ASP4657, ASP4667, ASP9347, GLN12388, GLN2747, GLN4677, GLU12188, GLU12458, GLU20238, GLU5097, GLU5197, GLU6067, GLU7877, GLU9317, GLU9857, GLU9897, GLU9967, GLY18338, GLY18358, HIS10217, HIS11738, HIS12068, HIS12428, HIS12608, HIS12678, HIS20198, HIS2527, HIS5467, HIS9217, HIS9647, LYS10367, LYS11638, LYS11858, LYS12728, LYS13948, LYS16868, LYS19428, LYS20228, LYS2777, LYS5167, LYS5437, LYS9437, PRO12468, SER19768, TYR20748, TYR4127, VAL14018