3L4G

crystal structure of homo sapiens cytoplasmic phenylalanyl-trna synthetase

• Total interactions analyzed: 120
• Total true interactions: 45
• Strongest Interaction:
  • Chains: K-L
  • Int. Res.: 355
  • Norm. En. per Res.: -3.8128
• Hub Node: A(6)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-197.7939	-78.4219	-1050.41	-1326.6258	357	101	27	45118	10	122	105
A-C	-7.1495	2.4434	-31.756	-36.4621	31	0	1	1520	0	8	8
A-D	-70.6993	-30.24	-447.17	-548.1093	166	44	13	20633	1	33	36
A-F	0.0	0.0	-1.9051	-1.9051	17	0	0	288	0	5	2
A-G	0.0	0.0	-0.0226	-0.0226	2	0	0	13	0	2	2
A-H	0.0	0.0	-4.9238	-4.9238	8	0	0	377	0	6	3
B-C	-89.2977	-13.8917	-467.473	-570.6624	185	52	13	22091	3	39	47
B-D	0.0	2.4571	-86.4606	-84.0035	38	1	6	3721	0	9	9
B-E	0.0	0.0	-1.1995	-1.1995	13	0	0	217	0	3	2
B-F	-8.3186	11.535	-97.6867	-94.4704	59	7	0	4582	0	6	7
B-G	0.0	0.0	-3.7676	-3.7676	7	0	0	300	0	6	3
C-D	-192.2954	-68.0858	-1046.28	-1306.6611	355	83	25	43937	8	121	108
C-E	0.0	0.0	-0.2541	-0.2541	4	0	0	41	0	5	2
C-F	0.0	0.0	-9.7619	-9.7619	12	0	0	536	0	6	3
C-H	0.0	0.0	-10.8945	-10.8945	34	2	1	772	0	13	11
D-E	0.0	0.0	-13.1682	-13.1682	11	0	0	598	0	6	3
D-G	0.0	0.0	-0.9735	-0.9735	16	0	0	196	0	3	2
D-H	0.0	34.6778	-83.0274	-48.3496	55	4	0	4131	0	6	6
E-F	-203.7823	-77.2971	-1048.78	-1329.8594	364	105	25	46059	9	124	102
E-G	0.0	11.6547	-27.2623	-15.6076	27	0	1	1381	0	10	4
E-H	-19.6679	-25.431	-403.992	-449.0909	159	35	12	18990	2	30	32
F-G	-48.4095	-13.0739	-379.555	-441.0384	163	66	8	17775	1	30	29
F-H	0.0	-0.2094	-81.6851	-81.8945	37	1	6	3639	0	8	9
F-I	0.0	0.0	-1.1799	-1.1799	7	0	0	107	0	2	1
F-J	-4.3476	-20.2939	-2.8306	-27.4721	13	2	0	420	2	7	3
F-K	-19.3917	-14.4931	-103.548	-137.4328	72	14	0	5087	2	26	22
F-L	0.0	-16.548	-79.3626	-95.9106	57	2	0	3855	4	21	26
G-H	-180.9572	-80.3476	-1063.12	-1324.4248	352	82	24	44901	11	119	108
I-J	-177.741	-73.6202	-1054.1	-1305.4612	360	111	27	45280	11	122	104
I-K	0.0	5.9841	-28.4712	-22.4871	28	2	1	1416	0	9	4
I-L	-69.4561	-35.8092	-402.556	-507.8213	161	33	12	18355	2	30	31
J-K	-75.3602	-46.3274	-458.201	-579.8886	169	38	9	19995	1	36	37
J-L	0.0	4.1934	-87.69	-83.4966	41	1	6	3729	0	10	9
J-M	0.0	0.0	-2.284	-2.284	17	0	0	314	0	5	2
J-N	-3.1514	10.6803	0.0	7.5289	4	0	0	0	0	0	0
K-L	-191.6666	-104.5917	-1057.29	-1353.5483	355	89	28	44712	8	119	101
K-M	0.0	0.0	-0.0324	-0.0324	2	0	0	15	0	3	2
L-M	0.0	0.0	-8.3527	-8.3527	12	0	0	547	0	6	3
L-P	0.0	13.7808			2
M-N	-167.9091	-81.143	-133.265	-382.3172	139	18	1	6159	2	36	25
M-O	0.0	1.1302			2
M-P	-23.5291	-5.8362			16
N-O	-78.1997	-30.8813			26
N-P	0.0	0.7043			5
O-P	-175.1115	-98.431			71

Interface residues

• A-B: ALA155B, ALA283A, ALA285A, ALA356B, ALA361B, ALA368A, ALA368B, ALA369B, ALA371B, ALA378A, ALA388B, ALA405B, ALA406B, ALA407B, ALA408A, ALA412B, ALA416B, ALA436B, ALA445B, ALA450B, ALA463B, ALA464B, ALA491B, ALA69B, ARG152B, ARG231A, ARG235A, ARG271A, ARG280A, ARG305B, ARG320A, ARG321B, ARG325A, ARG334A, ARG355A, ARG358A, ARG392A, ARG401B, ARG404A, ARG439A, ARG451B, ARG466B, ARG475A, ARG494A, ARG495B, ARG71B, ASN149B, ASN250A, ASN313A, ASN315B, ASN322A, ASN359A, ASN375B, ASN376B, ASN389B, ASN394B, ASN410A, ASN441B, ASN451A, ASN465B, ASN483A, ASN486B, ASN493B, ASN70B, ASP220A, ASP249A, ASP259B, ASP25B, ASP272A, ASP275A, ASP281A, ASP354A, ASP357B, ASP363A, ASP363B, ASP367B, ASP379A, ASP403B, ASP479B, ASP484B, ASP488B, ASP489A, ASP66B, CYS151B, CYS28B, CYS362B, CYS418B, GLN148B, GLN233A, GLN236A, GLN266A, GLN267A, GLN273A, GLN287A, GLN308A, GLN378B, GLN390B, GLN420B, GLN448B, GLN485A, GLU22B, GLU240A, GLU245A, GLU253A, GLU26B, GLU284A, GLU307B, GLU30B, GLU318A, GLU34B, GLU360A, GLU366B, GLU369A, GLU393A, GLU398B, GLU411B, GLU414A, GLU418A, GLU431A, GLU441A, GLU446B, GLU450A, GLU462A, GLU476A, GLU476B, GLY222A, GLY242A, GLY303A, GLY304A, GLY306A, GLY309A, GLY319B, GLY32B, GLY373B, GLY381A, GLY385A, GLY389A, GLY408B, GLY436A, GLY457B, GLY479A, GLY490B, HIS223A, HIS225A, HIS268A, HIS274A, HIS300A, HIS360B, HIS371A, HIS380A, HIS386A, HIS402B, HIS438B, HIS480A, ILE150B, ILE213B, ILE252A, ILE265B, ILE314B, ILE320B, ILE351B, ILE353A, ILE358B, ILE359B, ILE364B, ILE370B, ILE377B, ILE387B, ILE431B, ILE439B, ILE455A, ILE462B, ILE474A, ILE477B, ILE480B, ILE482B, LEU156B, LEU224A, LEU227A, LEU228A, LEU239A, LEU279A, LEU286A, LEU288A, LEU313B, LEU323A, LEU324A, LEU33B, LEU35B, LEU362A, LEU367A, LEU381B, LEU382A, LEU384A, LEU387A, LEU391A, LEU393B, LEU396B, LEU399B, LEU400B, LEU403A, LEU413B, LEU417B, LEU443A, LEU444A, LEU454B, LEU458B, LEU459B, LEU461A, LEU470B, LEU472B, LEU474B, LEU477A, LEU484A, LEU492A, LYS153B, LYS229A, LYS262B, LYS264B, LYS311A, LYS315A, LYS316B, LYS317B, LYS321A, LYS349A, LYS383B, LYS395B, LYS406A, LYS428A, LYS435B, LYS443B, LYS460B, LYS467B, LYS473B, LYS481A, LYS483B, LYS492B, MET1B, MET241A, MET246A, MET334B, MET379B, MET388A, MET404B, MET417A, MET468B, MET486A, PHE238A, PHE243A, PHE251A, PHE256A, PHE260B, PHE263A, PHE277A, PHE278A, PHE29B, PHE31B, PHE345A, PHE351A, PHE357A, PHE370A, PHE391B, PHE394A, PHE405A, PHE409B, PHE415B, PHE420A, PHE438A, PHE447B, PHE475B, PHE87B, PRO226A, PRO247A, PRO265A, PRO269A, PRO282A, PRO289A, PRO2B, PRO347A, PRO382B, PRO392B, PRO407A, PRO411A, PRO415A, PRO440A, PRO442B, PRO456B, PRO469B, PRO471B, PRO68B, SER221A, SER232A, SER254A, SER255A, SER307A, SER352A, SER416A, SER432B, SER435A, SER440B, SER453A, SER478B, SER485B, SER490A, THR244A, THR248A, THR258B, THR261B, THR276A, THR299A, THR346A, THR361A, THR380B, THR383A, THR384B, THR386B, THR397B, THR401A, THR410B, THR413A, THR414B, THR444B, THR461B, THR487B, TRP257A, TRP429A, TRP457A, TYR305A, TYR310A, TYR312A, TYR350A, TYR372B, TYR374B, TYR385B, TYR409A, TYR488A, TYR494B, TYR72B, VAL230A, VAL318B, VAL348A, VAL365B, VAL377A, VAL390A, VAL419A, VAL430A, VAL437A, VAL437B, VAL449B, VAL452A, VAL454A, VAL478A, VAL481B, VAL482A, VAL487A, VAL489B, VAL67B
• A-C: ARG235A, ARG235C, ARG494A, ASP220A, ASP220C, GLN236A, GLN236C, GLU240A, GLU240C, GLY222A, GLY222C, GLY242A, GLY242C, ILE237A, ILE237C, LEU239A, LEU239C, LYS397A, LYS397C, MET241A, MET241C, PHE238A, PHE238C, PHE243A, PHE243C, PHE351A, PHE351C, SER221A, SER221C, THR244A, THR244C
• A-D: ALA214A, ALA388D, ALA405D, ALA406D, ALA407D, ALA497A, ALA537D, ALA549D, ARG203A, ARG205A, ARG401D, ARG494A, ARG500A, ARG517D, ARG547D, ARG554D, ASN211A, ASN389D, ASN394D, ASN503D, ASN505D, ASP204A, ASP220A, ASP403D, ASP489A, ASP496A, ASP516D, ASP523D, ASP567D, CYS493A, CYS548D, CYS578D, GLN188A, GLN233A, GLN236A, GLN390D, GLN485A, GLN520D, GLU189A, GLU191A, GLU195A, GLU240A, GLU393A, GLU398D, GLU498A, GLU509D, GLU539D, GLU550D, GLY200A, GLY216A, GLY222A, GLY242A, GLY389A, GLY408D, GLY507D, GLY513D, GLY527D, GLY546D, GLY562D, HIS215A, HIS223A, HIS402D, HIS512D, HIS565D, ILE197A, ILE237A, ILE387D, ILE510D, ILE511D, ILE518D, ILE535D, ILE551D, ILE569D, LEU192A, LEU213A, LEU218A, LEU224A, LEU239A, LEU393D, LEU396D, LEU398A, LEU399D, LEU400D, LEU492A, LEU495A, LEU514D, LEU515D, LEU521D, LEU522D, LEU561D, LEU564D, LEU574D, LEU589D, LYS208A, LYS229A, LYS349A, LYS383D, LYS395D, LYS397A, LYS473D, LYS504D, LYS536D, LYS571D, MET196A, MET241A, MET404D, MET486A, MET519D, MET576D, PHE207A, PHE212A, PHE238A, PHE243A, PHE391D, PHE394A, PHE409D, PHE508D, PHE543D, PHE544D, PHE588D, PRO194A, PRO206A, PRO209A, PRO219A, PRO347A, PRO392D, PRO491A, PRO499A, PRO506D, PRO526D, PRO545D, PRO566D, PRO577D, SER193A, SER198A, SER199A, SER201A, SER221A, SER232A, SER490A, SER538D, SER579D, THR190A, THR346A, THR386D, THR396A, THR397D, THR570D, THR575D, TRP202A, TRP457A, TYR210A, TYR385D, TYR469A, TYR488A, TYR501D, TYR502D, TYR533D, VAL217A, VAL377A, VAL390A, VAL487A, VAL524D, VAL534D, VAL563D, VAL568D
• A-F: ARG321F, ARG392A, ARG404A, ASN345F, ASP343F, GLN402A, GLU325F, GLY342F, GLY344F, GLY385A, HIS386A, LEU384A, MET388A, PRO324F, THR323F, THR383A, THR401A
• A-G: ASN451A, ASN451G
• A-H: ARG310H, ASN345H, ASP312H, GLN346H, LYS343A, MET308H, PHE345A, PRO344A
• B-C: ALA214C, ALA388B, ALA405B, ALA406B, ALA407B, ALA46C, ALA497C, ALA507C, ALA537B, ALA549B, ARG203C, ARG205C, ARG401B, ARG494C, ARG500C, ARG517B, ARG547B, ARG554B, ASN211C, ASN389B, ASN503B, ASN505B, ASP220C, ASP403B, ASP489C, ASP496C, ASP516B, ASP523B, ASP529B, ASP567B, CYS493C, CYS548B, CYS578B, GLN233C, GLN236C, GLN390B, GLN45C, GLN485C, GLN505C, GLN520B, GLU189C, GLU191C, GLU195C, GLU240C, GLU393C, GLU398B, GLU498C, GLU49C, GLU506C, GLU509B, GLU528B, GLU539B, GLU550B, GLY200C, GLY216C, GLY222C, GLY242C, GLY389C, GLY408B, GLY48C, GLY507B, GLY513B, GLY527B, GLY531B, GLY532B, GLY546B, GLY555B, GLY562B, GLY586B, HIS215C, HIS223C, HIS402B, HIS512B, HIS565B, ILE197C, ILE237C, ILE387B, ILE510B, ILE511B, ILE518B, ILE535B, ILE551B, ILE569B, ILE585B, LEU192C, LEU213C, LEU218C, LEU224C, LEU239C, LEU393B, LEU396B, LEU398C, LEU399B, LEU400B, LEU47C, LEU492C, LEU495C, LEU514B, LEU515B, LEU521B, LEU522B, LEU561B, LEU564B, LEU574B, LEU589B, LYS187C, LYS208C, LYS229C, LYS349C, LYS383B, LYS395B, LYS397C, LYS42C, LYS473B, LYS504B, LYS530B, LYS536B, LYS571B, MET196C, MET241C, MET404B, MET486C, MET519B, MET576B, PHE207C, PHE212C, PHE238C, PHE243C, PHE394C, PHE409B, PHE508B, PHE543B, PHE544B, PHE588B, PRO194C, PRO206C, PRO209C, PRO219C, PRO347C, PRO392B, PRO491C, PRO499C, PRO501C, PRO502C, PRO503C, PRO506B, PRO525B, PRO526B, PRO545B, PRO566B, PRO577B, SER193C, SER198C, SER199C, SER201C, SER221C, SER232C, SER490C, SER538B, THR190C, THR346C, THR386B, THR396C, THR397B, THR504C, THR570B, THR575B, TRP202C, TRP457C, TYR210C, TYR385B, TYR469C, TYR488C, TYR501B, TYR502B, TYR533B, VAL217C, VAL377C, VAL390C, VAL487C, VAL50C, VAL524B, VAL534B, VAL563B, VAL568B
• B-D: ALA388B, ALA388D, ALA405B, ALA405D, ALA406B, ALA406D, ALA407B, ALA407D, ARG401B, ARG517D, ASP403B, ASP403D, GLU398B, GLU398D, GLY408B, GLY408D, HIS402B, HIS402D, ILE387B, ILE387D, LEU381B, LEU381D, LEU399B, LEU399D, LYS383B, LYS383D, MET404B, MET404D, PHE409B, PHE409D, PRO382B, PRO382D, THR384B, THR384D, THR386B, THR386D, TYR385B, TYR385D
• B-E: ARG321B, ARG392E, ASN345B, ASP343B, GLY342B, GLY344B, GLY385E, HIS386E, MET388E, PRO324B, THR323B, THR383E, THR401E
• B-F: ALA311B, ALA311F, ARG310B, ARG310F, ARG321B, ARG321F, ASN315B, ASN315F, ASN326B, ASN326F, ASN345B, ASN345F, ASN375B, ASN375F, ASN376B, ASN376F, ASP312B, ASP312F, ASP343F, GLN378B, GLN378F, GLU322B, GLU322F, GLU325B, GLU325F, GLY319B, GLY319F, GLY344B, GLY344F, GLY373B, GLY373F, ILE314F, ILE320B, ILE320F, ILE377B, ILE377F, LEU313F, LEU327B, LEU327F, LEU381B, LEU381F, LYS316B, LYS316F, LYS329B, LYS329F, MET379B, MET379F, PRO324B, PRO324F, THR323B, THR323F, THR380B, THR380F, TYR372B, TYR372F, TYR374B, TYR374F, VAL318B, VAL318F
• B-G: ARG310B, ASN345B, ASP312B, GLN346B, LYS343G, MET308B, PRO344G
• C-D: ALA155D, ALA283C, ALA285C, ALA356D, ALA361D, ALA368C, ALA368D, ALA369D, ALA371D, ALA378C, ALA388D, ALA405D, ALA406D, ALA407D, ALA408C, ALA412D, ALA416D, ALA436D, ALA450D, ALA463D, ALA464D, ALA491D, ALA69D, ARG152D, ARG231C, ARG235C, ARG271C, ARG280C, ARG305D, ARG320C, ARG321D, ARG325C, ARG334C, ARG355C, ARG358C, ARG392C, ARG401D, ARG404C, ARG439C, ARG451D, ARG466D, ARG475C, ARG494C, ARG495D, ARG71D, ASN149D, ASN250C, ASN313C, ASN315D, ASN322C, ASN359C, ASN375D, ASN376D, ASN389D, ASN394D, ASN410C, ASN441D, ASN451C, ASN465D, ASN483C, ASN486D, ASN493D, ASN70D, ASP220C, ASP249C, ASP259D, ASP25D, ASP272C, ASP275C, ASP281C, ASP354C, ASP357D, ASP363C, ASP363D, ASP367D, ASP36D, ASP379C, ASP403D, ASP422D, ASP479D, ASP484D, ASP488D, ASP489C, ASP66D, CYS151D, CYS28D, CYS362D, CYS418D, GLN233C, GLN236C, GLN266C, GLN267C, GLN273C, GLN287C, GLN308C, GLN378D, GLN390D, GLN420D, GLN448D, GLN485C, GLU240C, GLU245C, GLU253C, GLU26D, GLU284C, GLU307D, GLU30D, GLU318C, GLU34D, GLU360C, GLU366D, GLU369C, GLU393C, GLU398D, GLU411D, GLU414C, GLU418C, GLU431C, GLU441C, GLU446D, GLU450C, GLU462C, GLU476D, GLY222C, GLY242C, GLY303C, GLY304C, GLY306C, GLY309C, GLY319D, GLY32D, GLY373D, GLY381C, GLY385C, GLY389C, GLY408D, GLY436C, GLY457D, GLY479C, GLY490D, HIS223C, HIS225C, HIS268C, HIS274C, HIS300C, HIS360D, HIS366C, HIS371C, HIS380C, HIS386C, HIS402D, HIS438D, HIS480C, ILE150D, ILE213D, ILE252C, ILE265D, ILE314D, ILE320D, ILE351D, ILE353C, ILE358D, ILE359D, ILE364D, ILE370D, ILE377D, ILE387D, ILE431D, ILE439D, ILE455C, ILE462D, ILE474C, ILE477D, ILE480D, ILE482D, LEU156D, LEU224C, LEU227C, LEU228C, LEU239C, LEU279C, LEU286C, LEU288C, LEU313D, LEU323C, LEU324C, LEU33D, LEU35D, LEU362C, LEU367C, LEU381D, LEU382C, LEU384C, LEU387C, LEU391C, LEU393D, LEU396D, LEU399D, LEU400D, LEU403C, LEU413D, LEU417D, LEU443C, LEU444C, LEU454D, LEU458D, LEU459D, LEU461C, LEU472D, LEU474D, LEU477C, LEU484C, LYS153D, LYS229C, LYS262D, LYS264D, LYS311C, LYS316D, LYS317D, LYS321C, LYS349C, LYS383D, LYS395D, LYS406C, LYS428C, LYS435D, LYS443D, LYS460D, LYS467D, LYS473D, LYS47D, LYS481C, LYS483D, LYS492D, MET1D, MET241C, MET246C, MET334D, MET379D, MET388C, MET404D, MET417C, MET468D, MET486C, PHE120D, PHE238C, PHE243C, PHE251C, PHE256C, PHE260D, PHE263C, PHE277C, PHE278C, PHE29D, PHE31D, PHE345C, PHE351C, PHE357C, PHE370C, PHE391D, PHE394C, PHE405C, PHE409D, PHE415D, PHE420C, PHE438C, PHE447D, PHE475D, PHE87D, PRO226C, PRO247C, PRO265C, PRO269C, PRO282C, PRO289C, PRO2D, PRO347C, PRO382D, PRO392D, PRO407C, PRO411C, PRO415C, PRO440C, PRO442D, PRO456D, PRO469D, PRO471D, PRO68D, SER221C, SER232C, SER254C, SER255C, SER307C, SER352C, SER416C, SER435C, SER440D, SER453C, SER478D, SER485D, THR244C, THR248C, THR258D, THR261D, THR276C, THR299C, THR346C, THR361C, THR380D, THR383C, THR384D, THR386D, THR397D, THR401C, THR410D, THR413C, THR414D, THR444D, THR461D, THR465C, THR487D, TRP257C, TRP429C, TRP457C, TYR305C, TYR310C, TYR312C, TYR350C, TYR372D, TYR374D, TYR385D, TYR409C, TYR488C, TYR494D, TYR72D, VAL157D, VAL230C, VAL318D, VAL348C, VAL356C, VAL365D, VAL377C, VAL390C, VAL419C, VAL437C, VAL437D, VAL449D, VAL452C, VAL454C, VAL478C, VAL481D, VAL482C, VAL487C, VAL489D, VAL67D
• C-E: ASN451C, ASN451E, GLU450E, PRO449C
• C-F: ARG310F, ASN345F, ASP312F, GLN346F, LEU313F, LYS342C, LYS343C, MET308F, PHE345C, PRO344C, THR346C, VAL309F
• C-H: ALA119C, ALA120C, ARG114C, ARG321H, ARG392C, ASN345H, ASP102H, ASP116C, ASP121C, ASP343H, GLU288H, GLY103H, GLY122C, GLY342H, GLY344H, GLY385C, HIS386C, ILE105H, LYS104H, LYS107H, LYS117C, LYS295H, MET100H, MET388C, PRO101H, PRO123C, PRO324H, SER118C, SER296H, THR298H, THR323H, THR383C, THR401C, VAL290H
• D-E: ARG310D, ASN345D, ASP312D, GLN346D, LEU313D, LYS316D, LYS342E, LYS343E, MET308D, PHE345E, PRO344E
• D-G: ARG321D, ARG392G, ARG404G, ASN345D, ASP343D, GLN402G, GLU325D, GLY342D, GLY344D, GLY385G, HIS386G, MET388G, PRO324D, THR323D, THR383G, THR401G
• D-H: ALA311D, ALA311H, ARG321D, ARG321H, ASN315D, ASN315H, ASN326D, ASN326H, ASN345D, ASN345H, ASN375D, ASN375H, ASN376D, ASN376H, ASP312D, ASP312H, ASP343D, GLN378D, GLN378H, GLU322D, GLU322H, GLU325D, GLU325H, GLY319D, GLY319H, GLY344D, GLY344H, GLY373D, GLY373H, ILE320D, ILE320H, ILE377D, ILE377H, LEU327D, LEU327H, LEU381D, LEU381H, LYS316D, LYS316H, LYS329D, LYS329H, MET379D, MET379H, PRO324D, PRO324H, THR323D, THR323H, THR380D, THR380H, TYR372D, TYR372H, TYR374D, TYR374H, VAL318D, VAL318H
• E-F: ALA155F, ALA270E, ALA283E, ALA285E, ALA356F, ALA361F, ALA368E, ALA368F, ALA369F, ALA371F, ALA378E, ALA388F, ALA405F, ALA406F, ALA407F, ALA408E, ALA412F, ALA416F, ALA436F, ALA445F, ALA450F, ALA463F, ALA464F, ALA491F, ALA69F, ARG152F, ARG231E, ARG235E, ARG271E, ARG280E, ARG305F, ARG320E, ARG321F, ARG325E, ARG334E, ARG355E, ARG358E, ARG392E, ARG401F, ARG404E, ARG439E, ARG451F, ARG466F, ARG475E, ARG495F, ARG71F, ASN149F, ASN250E, ASN258E, ASN313E, ASN315F, ASN322E, ASN359E, ASN375F, ASN376F, ASN389F, ASN394F, ASN410E, ASN441F, ASN451E, ASN465F, ASN483E, ASN486F, ASN493F, ASN70F, ASP21F, ASP220E, ASP249E, ASP259F, ASP25F, ASP272E, ASP275E, ASP281E, ASP354E, ASP357F, ASP363E, ASP363F, ASP367F, ASP379E, ASP403F, ASP479F, ASP484F, ASP488F, ASP489E, ASP66F, CYS151F, CYS28F, CYS362F, CYS418F, GLN148F, GLN233E, GLN236E, GLN266E, GLN267E, GLN273E, GLN287E, GLN308E, GLN378F, GLN390F, GLN420F, GLN448F, GLN485E, GLU22F, GLU240E, GLU245E, GLU253E, GLU26F, GLU284E, GLU307F, GLU30F, GLU318E, GLU34F, GLU360E, GLU366F, GLU369E, GLU393E, GLU398F, GLU411F, GLU414E, GLU418E, GLU431E, GLU441E, GLU446F, GLU450E, GLU462E, GLU476F, GLY222E, GLY242E, GLY303E, GLY304E, GLY306E, GLY309E, GLY319F, GLY32F, GLY373F, GLY381E, GLY385E, GLY389E, GLY408F, GLY436E, GLY457F, GLY479E, GLY490F, HIS223E, HIS225E, HIS268E, HIS274E, HIS300E, HIS360F, HIS366E, HIS371E, HIS380E, HIS386E, HIS402F, HIS438F, HIS480E, ILE150F, ILE213F, ILE252E, ILE265F, ILE314F, ILE320F, ILE351F, ILE353E, ILE358F, ILE359F, ILE364F, ILE370F, ILE377F, ILE387F, ILE431F, ILE439F, ILE455E, ILE462F, ILE474E, ILE477F, ILE480F, ILE482F, LEU146F, LEU156F, LEU224E, LEU227E, LEU228E, LEU239E, LEU279E, LEU286E, LEU288E, LEU313F, LEU323E, LEU324E, LEU33F, LEU35F, LEU362E, LEU367E, LEU381F, LEU382E, LEU384E, LEU387E, LEU391E, LEU393F, LEU396F, LEU399F, LEU400F, LEU403E, LEU413F, LEU417F, LEU443E, LEU444E, LEU454F, LEU458F, LEU459F, LEU461E, LEU472F, LEU474F, LEU477E, LEU484E, LEU492E, LEU75F, LYS145F, LYS153F, LYS229E, LYS262F, LYS264F, LYS311E, LYS315E, LYS316F, LYS317F, LYS321E, LYS349E, LYS383F, LYS395F, LYS406E, LYS427E, LYS428E, LYS435F, LYS443F, LYS460F, LYS467F, LYS473F, LYS481E, LYS483F, LYS492F, MET1F, MET241E, MET246E, MET334F, MET379F, MET388E, MET404F, MET417E, MET468F, MET486E, PHE120F, PHE238E, PHE243E, PHE251E, PHE256E, PHE260F, PHE263E, PHE277E, PHE278E, PHE29F, PHE31F, PHE345E, PHE351E, PHE357E, PHE370E, PHE391F, PHE394E, PHE405E, PHE409F, PHE415F, PHE420E, PHE438E, PHE447F, PHE475F, PHE87F, PRO226E, PRO247E, PRO265E, PRO269E, PRO282E, PRO289E, PRO2F, PRO347E, PRO382F, PRO392F, PRO407E, PRO411E, PRO415E, PRO440E, PRO442F, PRO456F, PRO469F, PRO471F, PRO68F, SER221E, SER232E, SER254E, SER255E, SER301E, SER307E, SER352E, SER416E, SER421E, SER435E, SER440F, SER453E, SER478F, SER485F, THR244E, THR248E, THR258F, THR261F, THR276E, THR299E, THR346E, THR361E, THR380F, THR383E, THR384F, THR386F, THR397F, THR401E, THR410F, THR413E, THR414F, THR444F, THR461F, THR487F, TRP257E, TRP429E, TRP457E, TYR305E, TYR310E, TYR312E, TYR350E, TYR372F, TYR374F, TYR385F, TYR409E, TYR488E, TYR494F, TYR72F, VAL230E, VAL318F, VAL348E, VAL356E, VAL365F, VAL377E, VAL390E, VAL419E, VAL430E, VAL437E, VAL437F, VAL449F, VAL452E, VAL454E, VAL478E, VAL481F, VAL482E, VAL487E, VAL489F, VAL67F
• E-G: ARG235E, ARG235G, ASP220E, ASP220G, GLN236E, GLN236G, GLU240E, GLU240G, GLY222E, GLY222G, GLY242E, GLY242G, ILE237G, LEU239E, LEU239G, LYS397E, LYS397G, MET241E, MET241G, PHE238E, PHE238G, PHE243E, PHE243G, PHE351E, SER221G, THR244E, THR244G
• E-H: ALA214E, ALA388H, ALA405H, ALA406H, ALA407H, ALA497E, ALA537H, ALA549H, ARG203E, ARG205E, ARG401H, ARG494E, ARG517H, ARG547H, ARG554H, ASN211E, ASN389H, ASN394H, ASN503H, ASN505H, ASP204E, ASP220E, ASP403H, ASP489E, ASP496E, ASP516H, ASP523H, ASP567H, CYS493E, CYS548H, CYS578H, GLN233E, GLN236E, GLN390H, GLN485E, GLN520H, GLU191E, GLU195E, GLU240E, GLU393E, GLU398H, GLU498E, GLU509H, GLU550H, GLY200E, GLY216E, GLY222E, GLY242E, GLY389E, GLY408H, GLY507H, GLY513H, GLY527H, GLY546H, GLY562H, HIS215E, HIS223E, HIS402H, HIS512H, HIS565H, ILE197E, ILE237E, ILE387H, ILE510H, ILE511H, ILE518H, ILE535H, ILE551H, ILE569H, LEU192E, LEU213E, LEU218E, LEU224E, LEU239E, LEU393H, LEU396H, LEU398E, LEU399H, LEU400H, LEU492E, LEU495E, LEU514H, LEU515H, LEU521H, LEU522H, LEU561H, LEU564H, LEU574H, LEU589H, LYS208E, LYS229E, LYS349E, LYS383H, LYS395H, LYS397E, LYS473H, LYS504H, LYS536H, MET196E, MET241E, MET404H, MET519H, MET576H, PHE207E, PHE212E, PHE238E, PHE243E, PHE391H, PHE394E, PHE409H, PHE508H, PHE543H, PHE544H, PHE588H, PRO194E, PRO206E, PRO209E, PRO219E, PRO347E, PRO392H, PRO491E, PRO506H, PRO526H, PRO545H, PRO566H, PRO577H, PRO587H, SER193E, SER198E, SER199E, SER201E, SER221E, SER232E, SER490E, SER538H, SER579H, THR190E, THR346E, THR386H, THR396E, THR397H, THR570H, THR575H, TRP202E, TYR210E, TYR385H, TYR469E, TYR488E, TYR501H, TYR502H, TYR533H, VAL217E, VAL377E, VAL390E, VAL487E, VAL524H, VAL534H, VAL563H, VAL568H
• F-G: ALA214G, ALA388F, ALA405F, ALA406F, ALA407F, ALA537F, ALA549F, ARG203G, ARG401F, ARG494G, ARG517F, ARG547F, ARG554F, ASN211G, ASN389F, ASN394F, ASN503F, ASN505F, ASP204G, ASP220G, ASP403F, ASP489G, ASP496G, ASP516F, ASP523F, ASP567F, CYS493G, CYS548F, CYS578F, GLN233G, GLN236G, GLN390F, GLN485G, GLN520F, GLU189G, GLU191G, GLU195G, GLU240G, GLU393G, GLU398F, GLU509F, GLU539F, GLU550F, GLY200G, GLY216G, GLY222G, GLY242G, GLY389G, GLY408F, GLY507F, GLY513F, GLY527F, GLY546F, GLY562F, GLY586F, HIS215G, HIS223G, HIS402F, HIS512F, HIS565F, ILE197G, ILE237G, ILE387F, ILE510F, ILE511F, ILE518F, ILE535F, ILE569F, ILE585F, LEU192G, LEU213G, LEU218G, LEU224G, LEU239G, LEU393F, LEU396F, LEU398G, LEU399F, LEU400F, LEU492G, LEU495G, LEU514F, LEU515F, LEU521F, LEU522F, LEU561F, LEU564F, LEU574F, LEU589F, LYS208G, LYS229G, LYS349G, LYS383F, LYS395F, LYS397G, LYS473F, LYS504F, LYS536F, LYS571F, MET196G, MET241G, MET404F, MET486G, MET519F, MET576F, PHE207G, PHE212G, PHE238G, PHE243G, PHE391F, PHE394G, PHE409F, PHE508F, PHE543F, PHE544F, PHE588F, PRO194G, PRO206G, PRO209G, PRO219G, PRO347G, PRO392F, PRO491G, PRO506F, PRO525F, PRO526F, PRO545F, PRO566F, PRO577F, PRO587F, SER193G, SER198G, SER199G, SER201G, SER221G, SER232G, SER490G, SER538F, SER579F, THR190G, THR346G, THR386F, THR396G, THR397F, THR570F, THR575F, TRP202G, TRP457G, TYR210G, TYR385F, TYR469G, TYR488G, TYR501F, TYR502F, TYR533F, VAL217G, VAL377G, VAL390G, VAL487G, VAL524F, VAL534F, VAL563F, VAL568F
• F-H: ALA388F, ALA388H, ALA405F, ALA405H, ALA406F, ALA406H, ALA407F, ALA407H, ARG517F, ASP403F, ASP403H, GLU398F, GLU398H, GLY408F, GLY408H, HIS402F, HIS402H, ILE387F, ILE387H, LEU381F, LEU381H, LEU399F, LEU399H, LYS383F, LYS383H, MET404F, MET404H, PHE409F, PHE409H, PRO382F, PRO382H, THR384F, THR384H, THR386F, THR386H, TYR385F, TYR385H
• F-I: ARG249F, GLU195I, ILE197I, LYS130F, PRO194I, SER198I, SER199I
• F-J: ASP523J, GLN520J, GLY527J, LEU522J, LYS184F, LYS190F, LYS530J, PRO525J, PRO526J, THR189F, TYR192F, TYR533J, VAL524J
• F-K: ALA364K, ALA54F, ARG243F, ARG475K, ASN227F, ASN472K, ASN473K, ASN483K, ASN51F, ASP163F, ASP165F, ASP180F, ASP225F, ASP240F, ASP363K, ASP3K, ASP489K, GLN485K, GLU191F, GLU476K, GLY169F, GLY228F, GLY239F, GLY470K, GLY50F, HIS241F, HIS366K, HIS480K, ILE181F, ILE467K, ILE471K, ILE474K, LEU164F, LEU167F, LEU186F, LEU362K, LEU367K, LEU426K, LEU477K, LEU484K, LYS182F, LYS184F, LYS188F, LYS190F, LYS208K, LYS428K, LYS468K, LYS481K, LYS53F, MET466K, MET486K, PHE183F, PRO170F, PRO491K, SER168F, SER186K, SER226F, SER242F, SER490K, THR166F, THR189F, THR193F, THR365K, TYR192F, TYR224F, TYR469K, TYR488K, VAL229F, VAL230F, VAL482K, VAL487K, VAL52F
• F-L: ALA463L, ALA464L, ARG127F, ARG243F, ARG249F, ARG466L, ASN128F, ASN227F, ASN247F, ASN250F, ASN465L, ASN51L, ASP163F, ASP165F, ASP240F, GLN49L, GLU112F, GLU113F, GLU446L, GLU48L, GLU573L, GLY239F, GLY50L, HIS241F, ILE244F, ILE462L, LEU164F, LEU167F, LEU186F, LEU470L, LEU574L, LYS104F, LYS116F, LYS130F, LYS184F, LYS426L, LYS460L, LYS467L, LYS47L, LYS504L, MET468L, MET576L, PHE415L, PRO292F, PRO469L, SER168F, SER242F, SER46L, THR111F, THR166F, THR245F, THR248F, THR461L, THR575L, TYR502L, VAL246F, VAL52L
• G-H: ALA155H, ALA283G, ALA285G, ALA356H, ALA361H, ALA368G, ALA368H, ALA369H, ALA371H, ALA378G, ALA388H, ALA405H, ALA406H, ALA407H, ALA408G, ALA412H, ALA416H, ALA436H, ALA450H, ALA463H, ALA464H, ALA491H, ALA69H, ARG152H, ARG231G, ARG235G, ARG271G, ARG280G, ARG305H, ARG320G, ARG321H, ARG325G, ARG334G, ARG355G, ARG358G, ARG392G, ARG401H, ARG404G, ARG439G, ARG451H, ARG466H, ARG475G, ARG495H, ARG71H, ASN149H, ASN250G, ASN313G, ASN315H, ASN322G, ASN359G, ASN375H, ASN376H, ASN389H, ASN394H, ASN410G, ASN441H, ASN451G, ASN465H, ASN483G, ASN486H, ASN493H, ASN70H, ASP220G, ASP249G, ASP259H, ASP25H, ASP272G, ASP275G, ASP281G, ASP354G, ASP357H, ASP363H, ASP367H, ASP379G, ASP403H, ASP422H, ASP479H, ASP484H, ASP488H, ASP489G, ASP66H, CYS151H, CYS28H, CYS362H, CYS418H, GLN148H, GLN233G, GLN236G, GLN266G, GLN267G, GLN273G, GLN287G, GLN308G, GLN378H, GLN390H, GLN420H, GLN448H, GLN485G, GLU22H, GLU240G, GLU245G, GLU253G, GLU26H, GLU284G, GLU307H, GLU30H, GLU34H, GLU360G, GLU366H, GLU369G, GLU393G, GLU398H, GLU411H, GLU414G, GLU418G, GLU431G, GLU441G, GLU446H, GLU450G, GLU462G, GLU476H, GLY222G, GLY242G, GLY303G, GLY304G, GLY306G, GLY309G, GLY319H, GLY32H, GLY373H, GLY381G, GLY385G, GLY389G, GLY408H, GLY436G, GLY457H, GLY479G, GLY490H, HIS209H, HIS223G, HIS225G, HIS268G, HIS274G, HIS300G, HIS360H, HIS366G, HIS371G, HIS380G, HIS386G, HIS402H, HIS438H, HIS480G, ILE150H, ILE213H, ILE252G, ILE265H, ILE314H, ILE320H, ILE351H, ILE353G, ILE358H, ILE359H, ILE364H, ILE370H, ILE377H, ILE387H, ILE431H, ILE439H, ILE455G, ILE462H, ILE474G, ILE477H, ILE480H, ILE482H, LEU156H, LEU224G, LEU227G, LEU228G, LEU239G, LEU279G, LEU286G, LEU288G, LEU313H, LEU323G, LEU324G, LEU33H, LEU35H, LEU362G, LEU367G, LEU381H, LEU382G, LEU384G, LEU387G, LEU391G, LEU393H, LEU396H, LEU399H, LEU400H, LEU403G, LEU413H, LEU417H, LEU443G, LEU444G, LEU454H, LEU458H, LEU459H, LEU461G, LEU470H, LEU472H, LEU474H, LEU477G, LEU484G, LEU492G, LYS153H, LYS229G, LYS262H, LYS264H, LYS311G, LYS316H, LYS317H, LYS321G, LYS349G, LYS383H, LYS395H, LYS406G, LYS428G, LYS435H, LYS443H, LYS460H, LYS467H, LYS473H, LYS481G, LYS483H, LYS492H, MET1H, MET241G, MET246G, MET334H, MET379H, MET388G, MET404H, MET417G, MET468H, MET486G, PHE238G, PHE243G, PHE251G, PHE256G, PHE260H, PHE263G, PHE277G, PHE278G, PHE29H, PHE31H, PHE345G, PHE351G, PHE357G, PHE370G, PHE391H, PHE394G, PHE405G, PHE409H, PHE415H, PHE420G, PHE438G, PHE447H, PHE475H, PHE87H, PRO226G, PRO247G, PRO265G, PRO269G, PRO282G, PRO289G, PRO2H, PRO347G, PRO382H, PRO392H, PRO407G, PRO411G, PRO415G, PRO440G, PRO442H, PRO456H, PRO469H, PRO471H, PRO68H, SER221G, SER232G, SER254G, SER255G, SER307G, SER352G, SER416G, SER435G, SER440H, SER453G, SER478H, SER485H, SER490G, THR244G, THR248G, THR261H, THR276G, THR299G, THR346G, THR361G, THR380H, THR383G, THR384H, THR386H, THR397H, THR401G, THR410H, THR413G, THR414H, THR444H, THR461H, THR487H, TRP257G, TRP429G, TRP457G, TYR305G, TYR310G, TYR312G, TYR350G, TYR372H, TYR374H, TYR385H, TYR409G, TYR488G, TYR494H, TYR72H, VAL230G, VAL318H, VAL348G, VAL356G, VAL365H, VAL377G, VAL390G, VAL419G, VAL437G, VAL437H, VAL449H, VAL452G, VAL454G, VAL478G, VAL481H, VAL482G, VAL487G, VAL489H, VAL67H
• I-J: ALA155J, ALA283I, ALA285I, ALA356J, ALA361J, ALA368I, ALA368J, ALA369J, ALA371J, ALA378I, ALA388J, ALA405J, ALA406J, ALA407J, ALA408I, ALA412J, ALA416J, ALA436J, ALA445J, ALA450J, ALA463J, ALA464J, ALA491J, ALA69J, ARG152J, ARG231I, ARG235I, ARG271I, ARG280I, ARG305J, ARG320I, ARG321J, ARG325I, ARG334I, ARG355I, ARG358I, ARG392I, ARG401J, ARG404I, ARG439I, ARG451J, ARG466J, ARG475I, ARG495J, ARG71J, ASN149J, ASN250I, ASN313I, ASN315J, ASN322I, ASN359I, ASN375J, ASN376J, ASN389J, ASN394J, ASN410I, ASN441J, ASN451I, ASN465J, ASN483I, ASN486J, ASN493J, ASN70J, ASP220I, ASP249I, ASP259J, ASP25J, ASP272I, ASP275I, ASP281I, ASP354I, ASP357J, ASP363I, ASP363J, ASP367J, ASP379I, ASP403J, ASP422J, ASP479J, ASP484J, ASP488J, ASP489I, ASP66J, CYS151J, CYS28J, CYS362J, CYS418J, GLN148J, GLN233I, GLN236I, GLN266I, GLN267I, GLN273I, GLN287I, GLN308I, GLN378J, GLN390J, GLN420J, GLN448J, GLN485I, GLU22J, GLU240I, GLU245I, GLU253I, GLU26J, GLU284I, GLU307J, GLU30J, GLU318I, GLU34J, GLU360I, GLU366J, GLU369I, GLU393I, GLU398J, GLU411J, GLU414I, GLU418I, GLU431I, GLU441I, GLU446J, GLU450I, GLU462I, GLU476I, GLU476J, GLY222I, GLY242I, GLY303I, GLY304I, GLY306I, GLY309I, GLY319J, GLY32J, GLY373J, GLY381I, GLY385I, GLY389I, GLY408J, GLY436I, GLY457J, GLY479I, GLY490J, HIS209J, HIS223I, HIS225I, HIS268I, HIS274I, HIS300I, HIS360J, HIS366I, HIS371I, HIS380I, HIS386I, HIS402J, HIS438J, HIS480I, ILE150J, ILE252I, ILE265J, ILE314J, ILE320J, ILE351J, ILE353I, ILE358J, ILE359J, ILE364J, ILE370J, ILE377J, ILE387J, ILE431J, ILE439J, ILE455I, ILE462J, ILE474I, ILE477J, ILE480J, ILE482J, LEU156J, LEU224I, LEU227I, LEU228I, LEU239I, LEU279I, LEU27J, LEU286I, LEU288I, LEU313J, LEU323I, LEU324I, LEU33J, LEU35J, LEU362I, LEU367I, LEU381J, LEU382I, LEU384I, LEU387I, LEU391I, LEU393J, LEU396J, LEU399J, LEU400J, LEU403I, LEU413J, LEU417J, LEU443I, LEU444I, LEU454J, LEU458J, LEU459J, LEU461I, LEU472J, LEU474J, LEU477I, LEU484I, LEU492I, LYS153J, LYS229I, LYS262J, LYS264J, LYS311I, LYS315I, LYS316J, LYS317J, LYS321I, LYS349I, LYS383J, LYS395J, LYS406I, LYS428I, LYS435J, LYS443J, LYS460J, LYS467J, LYS473J, LYS481I, LYS483J, LYS492J, MET1J, MET241I, MET246I, MET334J, MET379J, MET388I, MET404J, MET417I, MET468J, MET486I, PHE120J, PHE238I, PHE243I, PHE251I, PHE256I, PHE260J, PHE263I, PHE277I, PHE278I, PHE29J, PHE31J, PHE345I, PHE351I, PHE357I, PHE370I, PHE391J, PHE394I, PHE405I, PHE409J, PHE415J, PHE420I, PHE438I, PHE447J, PHE475J, PHE87J, PRO226I, PRO247I, PRO265I, PRO269I, PRO282I, PRO289I, PRO2J, PRO347I, PRO382J, PRO392J, PRO407I, PRO411I, PRO415I, PRO440I, PRO442J, PRO456J, PRO469J, PRO471J, PRO68J, SER221I, SER232I, SER254I, SER255I, SER301I, SER307I, SER352I, SER416I, SER421I, SER435I, SER440J, SER453I, SER478J, SER485J, THR244I, THR248I, THR258J, THR261J, THR276I, THR299I, THR346I, THR361I, THR380J, THR383I, THR384J, THR386J, THR397J, THR401I, THR410J, THR413I, THR414J, THR444J, THR461J, THR487J, TRP257I, TRP429I, TRP457I, TYR305I, TYR310I, TYR312I, TYR350I, TYR372J, TYR374J, TYR385J, TYR409I, TYR488I, TYR494J, TYR72J, VAL230I, VAL318J, VAL348I, VAL356I, VAL365J, VAL377I, VAL390I, VAL419I, VAL430I, VAL437I, VAL437J, VAL449J, VAL452I, VAL454I, VAL478I, VAL481J, VAL482I, VAL487I, VAL489J, VAL67J
• I-K: ARG235I, ARG235K, ASP220I, ASP220K, GLN236I, GLN236K, GLU240I, GLU240K, GLY222I, GLY222K, GLY242I, GLY242K, ILE237K, LEU239I, LEU239K, LYS397I, LYS397K, MET241I, MET241K, PHE238I, PHE238K, PHE243I, PHE243K, PHE351I, SER221I, SER221K, THR244I, THR244K
• I-L: ALA214I, ALA388L, ALA405L, ALA406L, ALA407L, ALA497I, ALA537L, ALA549L, ARG203I, ARG205I, ARG401L, ARG494I, ARG517L, ARG547L, ARG554L, ASN211I, ASN389L, ASN503L, ASN505L, ASP204I, ASP220I, ASP403L, ASP489I, ASP496I, ASP516L, ASP523L, ASP567L, CYS493I, CYS548L, CYS578L, GLN233I, GLN236I, GLN390L, GLN485I, GLN520L, GLU189I, GLU191I, GLU195I, GLU240I, GLU393I, GLU398L, GLU498I, GLU509L, GLU528L, GLU550L, GLY200I, GLY216I, GLY222I, GLY242I, GLY389I, GLY408L, GLY507L, GLY513L, GLY527L, GLY546L, GLY562L, GLY586L, HIS215I, HIS223I, HIS402L, HIS512L, HIS565L, ILE197I, ILE237I, ILE387L, ILE510L, ILE511L, ILE518L, ILE535L, ILE569L, ILE585L, LEU192I, LEU213I, LEU218I, LEU224I, LEU239I, LEU393L, LEU396L, LEU398I, LEU399L, LEU400L, LEU492I, LEU495I, LEU514L, LEU515L, LEU521L, LEU522L, LEU561L, LEU564L, LEU574L, LEU589L, LYS208I, LYS229I, LYS349I, LYS383L, LYS395L, LYS397I, LYS473L, LYS504L, LYS536L, MET196I, MET241I, MET404L, MET486I, MET519L, MET576L, PHE207I, PHE212I, PHE238I, PHE243I, PHE394I, PHE409L, PHE508L, PHE543L, PHE544L, PHE588L, PRO194I, PRO206I, PRO209I, PRO219I, PRO347I, PRO392L, PRO491I, PRO506L, PRO526L, PRO545L, PRO566L, PRO577L, PRO587L, SER193I, SER198I, SER199I, SER201I, SER221I, SER232I, SER490I, SER538L, SER579L, THR190I, THR346I, THR386L, THR396I, THR397L, THR570L, THR575L, TRP202I, TRP457I, TYR210I, TYR385L, TYR488I, TYR501L, TYR502L, TYR533L, VAL217I, VAL377I, VAL390I, VAL487I, VAL524L, VAL534L, VAL563L, VAL568L
• J-K: ALA214K, ALA388J, ALA405J, ALA406J, ALA407J, ALA46K, ALA497K, ALA537J, ALA549J, ARG203K, ARG205K, ARG401J, ARG494K, ARG517J, ARG547J, ARG554J, ASN211K, ASN389J, ASN503J, ASN505J, ASP220K, ASP403J, ASP489K, ASP496K, ASP516J, ASP523J, ASP567J, CYS493K, CYS548J, CYS578J, GLN233K, GLN236K, GLN390J, GLN45K, GLN485K, GLN520J, GLU189K, GLU191K, GLU195K, GLU240K, GLU393K, GLU398J, GLU498K, GLU509J, GLU539J, GLU550J, GLY178K, GLY200K, GLY216K, GLY222K, GLY242K, GLY389K, GLY408J, GLY470K, GLY507J, GLY513J, GLY527J, GLY546J, GLY562J, HIS215K, HIS223K, HIS402J, HIS512J, HIS565J, ILE197K, ILE237K, ILE387J, ILE510J, ILE511J, ILE518J, ILE535J, ILE569J, LEU192K, LEU213K, LEU218K, LEU224K, LEU239K, LEU393J, LEU396J, LEU398K, LEU399J, LEU400J, LEU44K, LEU492K, LEU495K, LEU514J, LEU515J, LEU521J, LEU522J, LEU561J, LEU564J, LEU574J, LEU589J, LYS177K, LYS208K, LYS229K, LYS349K, LYS383J, LYS395J, LYS397K, LYS42K, LYS468K, LYS473J, LYS504J, LYS536J, MET196K, MET241K, MET404J, MET486K, MET519J, MET576J, PHE207K, PHE212K, PHE234K, PHE238K, PHE243K, PHE394K, PHE409J, PHE508J, PHE544J, PHE588J, PRO194K, PRO206K, PRO209K, PRO219K, PRO347K, PRO392J, PRO491K, PRO506J, PRO525J, PRO526J, PRO545J, PRO566J, PRO577J, PRO587J, SER193K, SER198K, SER199K, SER201K, SER221K, SER232K, SER43K, SER490K, SER538J, SER579J, THR190K, THR346K, THR386J, THR396K, THR397J, THR570J, THR575J, TRP202K, TRP457K, TYR210K, TYR385J, TYR469K, TYR488K, TYR501J, TYR502J, TYR533J, VAL217K, VAL377K, VAL390K, VAL487K, VAL524J, VAL534J, VAL563J, VAL568J
• J-L: ALA388J, ALA388L, ALA405J, ALA405L, ALA406J, ALA406L, ALA407J, ALA407L, ARG401J, ARG401L, ARG517J, ARG517L, ASP403J, ASP403L, GLU398J, GLU398L, GLY408J, GLY408L, HIS402J, HIS402L, ILE387J, ILE387L, LEU381J, LEU381L, LEU399J, LEU399L, LYS383J, LYS383L, MET404J, MET404L, PHE409J, PHE409L, PRO382J, PRO382L, THR384J, THR384L, THR386J, THR386L, THR410L, TYR385J, TYR385L
• J-M: ARG321J, ARG392M, ARG404M, ASN345J, ASP343J, GLN402M, GLU325J, GLY342J, GLY344J, GLY385M, HIS386M, LEU384M, MET388M, PRO324J, THR323J, THR383M, THR401M
• J-N: ARG321J, ARG321N, GLU322N, TYR372J
• K-L: ALA155L, ALA283K, ALA285K, ALA356L, ALA361L, ALA364K, ALA368K, ALA368L, ALA369L, ALA371L, ALA378K, ALA388L, ALA405L, ALA406L, ALA407L, ALA408K, ALA412L, ALA416L, ALA436L, ALA445L, ALA450L, ALA463L, ALA464L, ALA491L, ALA69L, ARG152L, ARG231K, ARG235K, ARG271K, ARG280K, ARG305L, ARG320K, ARG321L, ARG325K, ARG334K, ARG355K, ARG358K, ARG392K, ARG401L, ARG404K, ARG439K, ARG451L, ARG466L, ARG475K, ARG495L, ARG71L, ASN149L, ASN250K, ASN313K, ASN315L, ASN322K, ASN359K, ASN375L, ASN376L, ASN389L, ASN394L, ASN410K, ASN441L, ASN451K, ASN465L, ASN483K, ASN486L, ASN493L, ASN70L, ASP220K, ASP249K, ASP259L, ASP25L, ASP272K, ASP275K, ASP281K, ASP354K, ASP357L, ASP363K, ASP363L, ASP367L, ASP379K, ASP403L, ASP422L, ASP479L, ASP484L, ASP488L, ASP489K, ASP66L, CYS151L, CYS28L, CYS362L, CYS418L, GLN148L, GLN233K, GLN236K, GLN266K, GLN267K, GLN273K, GLN287K, GLN308K, GLN378L, GLN390L, GLN420L, GLN448L, GLN485K, GLU240K, GLU245K, GLU253K, GLU26L, GLU284K, GLU307L, GLU30L, GLU318K, GLU34L, GLU360K, GLU366L, GLU369K, GLU393K, GLU398L, GLU411L, GLU414K, GLU418K, GLU431K, GLU441K, GLU446L, GLU450K, GLU462K, GLU476L, GLY222K, GLY242K, GLY303K, GLY304K, GLY306K, GLY309K, GLY319L, GLY32L, GLY373L, GLY381K, GLY385K, GLY389K, GLY408L, GLY436K, GLY457L, GLY479K, GLY490L, HIS223K, HIS225K, HIS268K, HIS274K, HIS300K, HIS360L, HIS366K, HIS371K, HIS380K, HIS386K, HIS402L, HIS438L, HIS480K, ILE150L, ILE213L, ILE252K, ILE265L, ILE314L, ILE320L, ILE351L, ILE353K, ILE358L, ILE359L, ILE364L, ILE370L, ILE377L, ILE387L, ILE439L, ILE455K, ILE462L, ILE474K, ILE477L, ILE480L, ILE482L, LEU156L, LEU224K, LEU227K, LEU228K, LEU239K, LEU279K, LEU286K, LEU288K, LEU313L, LEU323K, LEU324K, LEU33L, LEU35L, LEU362K, LEU367K, LEU381L, LEU382K, LEU384K, LEU387K, LEU391K, LEU393L, LEU396L, LEU399L, LEU400L, LEU403K, LEU413L, LEU417L, LEU443K, LEU444K, LEU454L, LEU458L, LEU459L, LEU461K, LEU470L, LEU472L, LEU474L, LEU477K, LEU484K, LYS153L, LYS229K, LYS262L, LYS264L, LYS306L, LYS311K, LYS316L, LYS317L, LYS321K, LYS349K, LYS383L, LYS395L, LYS406K, LYS435L, LYS443L, LYS460L, LYS467L, LYS473L, LYS481K, LYS483L, LYS492L, MET1L, MET241K, MET246K, MET334L, MET379L, MET388K, MET404L, MET417K, MET468L, MET486K, PHE120L, PHE238K, PHE243K, PHE251K, PHE256K, PHE260L, PHE263K, PHE277K, PHE278K, PHE29L, PHE31L, PHE345K, PHE351K, PHE357K, PHE370K, PHE391L, PHE394K, PHE405K, PHE409L, PHE415L, PHE420K, PHE438K, PHE447L, PHE475L, PHE87L, PRO226K, PRO247K, PRO265K, PRO269K, PRO282K, PRO289K, PRO2L, PRO347K, PRO382L, PRO392L, PRO407K, PRO411K, PRO415K, PRO440K, PRO442L, PRO456L, PRO469L, PRO471L, PRO68L, SER221K, SER232K, SER254K, SER255K, SER307K, SER352K, SER416K, SER419L, SER435K, SER440L, SER453K, SER478L, SER485L, THR244K, THR248K, THR258L, THR261L, THR276K, THR299K, THR346K, THR361K, THR380L, THR383K, THR384L, THR386L, THR397L, THR401K, THR410L, THR413K, THR414L, THR444L, THR461L, THR465K, THR487L, TRP257K, TRP429K, TRP457K, TYR305K, TYR310K, TYR312K, TYR350K, TYR372L, TYR374L, TYR385L, TYR409K, TYR488K, TYR494L, TYR72L, VAL230K, VAL318L, VAL348K, VAL356K, VAL365L, VAL377K, VAL390K, VAL419K, VAL437K, VAL437L, VAL449L, VAL452K, VAL454K, VAL478K, VAL481L, VAL482K, VAL487K, VAL489L, VAL67L
• K-M: ASN451K, ASN451M
• L-M: ARG310L, ASN345L, ASP312L, ASP343L, GLN346L, LEU313L, LYS316L, LYS342M, LYS343M, MET308L, PHE345M, PRO344M
• L-P: ARG321L, ARG321P
• M-N: ALA155N, ALA270M, ALA408M, ALA416N, ALA69N, ARG152N, ARG231M, ARG235M, ARG271M, ARG280M, ARG305N, ARG334M, ARG355M, ARG401N, ARG404M, ARG439M, ARG495N, ARG71N, ASN149N, ASN313M, ASN322M, ASN375N, ASN389N, ASN410M, ASN465N, ASN70N, ASP220M, ASP249M, ASP259N, ASP25N, ASP272M, ASP281M, ASP354M, ASP363N, ASP479N, ASP488N, ASP66N, CYS151N, CYS28N, GLN148N, GLN266M, GLN267M, GLN273M, GLN308M, GLN390N, GLU245M, GLU253M, GLU26N, GLU30N, GLU318M, GLU34N, GLU360M, GLU366N, GLU369M, GLU398N, GLU411N, GLU414M, GLU418M, GLU431M, GLU441M, GLU476N, GLY309M, GLY32N, HIS209N, HIS223M, HIS225M, HIS268M, HIS274M, HIS300M, HIS360N, HIS386M, HIS438N, HIS480M, ILE150N, ILE213N, ILE265N, ILE359N, LEU156N, LEU27N, LEU33N, LEU35N, LEU484M, LYS153N, LYS229M, LYS262N, LYS264N, LYS311M, LYS315M, LYS317N, LYS321M, LYS349M, LYS383N, LYS395N, LYS406M, LYS428M, LYS443N, LYS460N, LYS473N, LYS481M, LYS483N, LYS492N, MET1N, MET417M, PHE260N, PHE278M, PHE29N, PHE31N, PHE391N, PHE405M, PHE409N, PHE420M, PHE87N, PRO265M, PRO269M, PRO2N, PRO407M, PRO411M, PRO415M, PRO68N, SER301M, SER416M, SER440N, SER478N, THR258N, THR261N, THR384N, THR413M, TRP314M, TRP429M, TYR310M, TYR312M, TYR374N, TYR409M, TYR72N, VAL419M, VAL430M, VAL482M, VAL489N, VAL67N
• M-O: GLU240M, GLU240O
• M-P: ALA388P, ARG494M, ARG547P, ASP403P, ASP516P, ASP523P, GLU240M, HIS215M, HIS223M, HIS512P, LEU492M, LEU521P, LEU589P, LYS208M, LYS395P, LYS397M
• N-O: ALA388N, ARG494O, ARG517N, ARG547N, ASN389N, ASP403N, ASP489O, ASP496O, ASP516N, ASP523N, GLN520N, GLU191O, GLU195O, GLU240O, GLU509N, HIS215O, HIS223O, HIS512N, LEU492O, LEU521N, LYS208O, LYS395N, LYS397O, LYS504N, PHE588N, TYR488O
• N-P: ARG401P, ASP403N, ASP403P, HIS402N, HIS402P
• O-P: ALA416P, ARG152P, ARG231O, ARG235O, ARG280O, ARG305P, ARG334O, ARG355O, ARG401P, ARG439O, ARG495P, ASN322O, ASN375P, ASN389P, ASN441P, ASN465P, ASP220O, ASP249O, ASP25P, ASP272O, ASP281O, ASP354O, ASP363P, ASP479P, ASP488P, GLN308O, GLN390P, GLU245O, GLU253O, GLU34P, GLU366P, GLU369O, GLU398P, GLU411P, GLU414O, GLU418O, GLU441O, GLU476P, HIS223O, HIS225O, HIS268O, HIS360P, HIS386O, HIS438P, HIS480O, ILE359P, LEU417P, LEU484O, LYS153P, LYS229O, LYS264P, LYS311O, LYS317P, LYS349O, LYS383P, LYS395P, LYS406O, LYS428O, LYS460P, LYS473P, LYS481O, LYS483P, LYS492P, PHE278O, PHE391P, PHE405O, PHE409P, SER440P, THR384P, THR386P, VAL489P