3L3S

crystal structure of an enoyl-coa hydrotase/isomerase family protein from silicibacter pomeroyi

• Total interactions analyzed: 66
• Total true interactions: 32
• Strongest Interaction:
  • Chains: A-B
  • Int. Res.: 152
  • Norm. En. per Res.: -3.4339
• Hub Node: B(6)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-59.8894	-34.4217	-427.643	-521.9542	152	19	16	18351	1	16	20
A-C	-48.5854	-2.8006	-419.5	-470.886	157	24	16	18276	0	20	26
A-D	-2.2932	-19.9058	-67.8575	-90.0565	48	3	3	3450	1	10	13
A-E	0.0	-8.5338	-2.0848	-10.6186	25	0	0	318	0	15	18
A-F	0.0	24.0611	-12.5348	11.5263	9	1	0	345	0	2	2
B-C	-58.101	-4.6424	-414.405	-477.1484	157	20	14	17945	0	23	28
B-D	0.0	-10.7984	-1.9135	-12.7119	30	0	0	336	0	24	23
B-E	0.0	15.8261	-9.5288	6.2973	8	2	0	367	0	0	3
B-F	-5.9688	-12.7236	-72.013	-90.7054	48	2	3	3582	0	10	12
B-G	0.0	2.3416	-41.8356	-39.494	44	1	2	1988	0	11	7
B-H	-7.3042	-6.6297	-44.047	-57.9809	37	4	1	2194	0	8	6
C-D	0.0	29.0039	-13.3166	15.6873	11	1	0	485	0	3	4
C-E	0.0	-21.2003	-63.6696	-84.8699	48	5	3	3255	0	8	12
C-F	0.0	0.0	-1.3573	-1.3573	28	0	0	269	0	14	19
D-E	-56.8074	-3.3087	-411.466	-471.5821	155	20	16	17797	0	20	22
D-F	-60.0107	-2.8981	-398.574	-461.4828	154	19	16	17575	0	18	25
E-F	-50.076	-7.6178	-405.194	-462.8878	157	22	15	17890	0	18	23
G-H	-65.9928	-12.2734	-408.851	-487.1172	159	20	16	17748	0	20	24
G-I	-53.2421	-5.1057	-408.297	-466.6449	156	19	17	17702	0	19	24
G-J	0.0	26.1366	-12.4429	13.6937	12	2	0	476	0	2	3
G-K	0.0	-15.875	-63.3898	-79.2648	48	1	3	3446	0	11	14
G-L	0.0	-7.4159	-1.4801	-8.8959	23	0	0	280	0	20	21
H-I	-57.5512	-6.4005	-399.12	-463.0717	157	25	16	17806	0	20	25
H-J	-5.7936	-5.6353	-63.5123	-74.9412	49	2	3	3490	0	9	12
H-K	0.0	-8.9377	-6.8045	-15.7423	27	4	0	454	0	18	22
H-L	0.0	36.5556	-7.4551	29.1005	12	5	0	479	0	2	3
I-J	0.0	-5.5968	-2.5612	-8.158	25	0	0	308	0	20	23
I-K	0.0	39.5609	-12.594	26.9669	11	1	0	440	0	2	3
I-L	0.0	-13.6675	-72.8561	-86.5236	48	3	3	3646	0	10	12
J-K	-54.2919	-11.7533	-395.854	-461.8992	156	20	15	17554	0	20	24
J-L	-53.7397	-1.2023	-406.658	-461.6	155	23	16	17944	0	20	24
K-L	-53.7985	-7.4576	-406.171	-467.4271	155	22	16	17911	0	22	25

Interface residues

• A-B: ALA102A, ALA102B, ALA110A, ALA118B, ALA125A, ALA125B, ALA126A, ALA126B, ALA130A, ALA153B, ALA155A, ALA155B, ALA164B, ALA169B, ALA173B, ALA180A, ALA182A, ALA182B, ALA183A, ALA183B, ALA203A, ALA205A, ALA208A, ALA212A, ALA232A, ALA234A, ALA236A, ALA85B, ALA93B, ALA96B, ARG158A, ARG158B, ARG162A, ARG162B, ARG163B, ARG188A, ARG209A, ARG215A, ARG216A, ARG223A, ARG223B, ARG84B, ASN145B, ASN187A, ASN210A, ASN222A, ASN222B, ASP100B, ASP128A, ASP176B, ASP69B, ASP89B, CYS127A, CYS94B, GLN122A, GLN122B, GLN144B, GLN211A, GLN231A, GLU167B, GLU219A, GLU226A, GLU226B, GLU230A, GLU242A, GLU92B, GLY142B, GLY146B, GLY147B, GLY161B, GLY172B, GLY184A, GLY217A, HIS103A, HIS103B, HIS198A, HIS224A, HIS243A, HIS68B, ILE109A, ILE160A, ILE160B, ILE186A, LEU101B, LEU121A, LEU123A, LEU123B, LEU129A, LEU140B, LEU170B, LEU181A, LEU185A, LEU190A, LEU202A, LEU206A, LEU214A, LEU218A, LEU221A, LEU225A, LEU225B, LEU227A, LEU227B, LEU229A, LEU229B, LEU235A, LEU70B, LEU90B, LEU97B, LEU99B, LYS106A, LYS71B, PHE138A, PHE148B, PHE244A, PHE86B, PHE91B, PRO105A, PRO107A, PRO141B, PRO152B, PRO213A, PRO228A, PRO228B, PRO238A, SER157A, SER157B, SER95B, THR108A, THR150B, THR151B, THR166B, THR171B, THR174B, THR220A, THR237A, THR88B, TRP179B, TYR131A, TYR175B, TYR233A, VAL112A, VAL143B, VAL154B, VAL156A, VAL156B, VAL159A, VAL159B, VAL165B, VAL239A, VAL241A, VAL54A, VAL87B
• A-C: ALA102A, ALA102C, ALA110C, ALA118A, ALA125A, ALA125C, ALA126A, ALA126C, ALA130C, ALA153A, ALA155A, ALA155C, ALA164A, ALA169A, ALA173A, ALA180C, ALA182A, ALA182C, ALA183A, ALA183C, ALA203C, ALA205C, ALA208C, ALA212C, ALA232C, ALA234C, ALA236C, ALA85A, ALA93A, ALA96A, ARG158A, ARG158C, ARG162A, ARG162C, ARG163A, ARG188C, ARG209C, ARG215C, ARG216C, ARG223A, ARG223C, ARG84A, ASN145A, ASN187C, ASN210C, ASN222A, ASN222C, ASP100A, ASP128C, ASP246C, ASP69A, ASP89A, CYS127C, CYS94A, GLN122A, GLN122C, GLN144A, GLN211C, GLN231C, GLU167A, GLU219C, GLU226A, GLU226C, GLU230C, GLU242C, GLU72A, GLU82A, GLU92A, GLY142A, GLY146A, GLY147A, GLY161A, GLY161C, GLY172A, GLY184C, GLY217C, GLY248C, GLY67A, GLY83A, HIS103A, HIS103C, HIS198C, HIS224C, HIS243C, HIS68A, ILE109C, ILE160A, ILE160C, ILE186C, LEU101A, LEU121C, LEU123C, LEU129C, LEU140A, LEU170A, LEU181C, LEU185C, LEU190C, LEU202C, LEU206C, LEU214C, LEU218C, LEU221C, LEU225A, LEU225C, LEU227A, LEU227C, LEU229A, LEU229C, LEU235C, LEU70A, LEU90A, LEU99A, LYS106C, LYS71A, PHE138C, PHE148A, PHE244C, PHE86A, PHE91A, PRO105C, PRO107C, PRO141A, PRO152A, PRO213C, PRO228A, PRO228C, PRO238C, PRO247C, SER157A, SER157C, SER95A, THR108C, THR150A, THR151A, THR166A, THR171A, THR220C, THR237C, THR88A, TRP179A, TYR131C, TYR175A, TYR233C, VAL112C, VAL143A, VAL154A, VAL154C, VAL156A, VAL156C, VAL159A, VAL159C, VAL165A, VAL239C, VAL241C, VAL54C, VAL87A
• A-D: ALA232A, ALA232D, ALA234A, ALA234D, ALA236A, ALA236D, ARG216A, ARG216D, ARG223A, ARG223D, ASN222A, ASN222D, GLN231A, GLN231D, GLU219A, GLU219D, GLU226A, GLU226D, GLU230A, GLU230D, GLU242A, GLU242D, HIS103A, HIS103D, HIS224A, HIS224D, LEU225A, LEU225D, LEU227A, LEU227D, LEU235A, LEU235D, LEU99A, LEU99D, PRO228A, PRO228D, PRO238A, PRO238D, THR220A, THR220D, THR237A, THR237D, TYR233A, TYR233D, VAL239A, VAL239D, VAL241A, VAL241D
• A-E: ARG216A, ARG216E, ARG223A, ARG223E, ARG44A, ARG44E, ARG84A, ARG84E, ASP246E, ASP81A, GLU219A, GLU219E, GLU242A, GLU242E, GLU92A, GLU92E, LEU99A, LEU99E, PRO238A, PRO247E, SER95A, THR88A, THR88E, VAL241A, VAL241E
• A-F: ARG84A, ARG84F, GLN231A, GLN231F, GLU230A, GLU230F, LEU229A, PRO228A, PRO228F
• B-C: ALA102B, ALA102C, ALA110B, ALA118C, ALA119C, ALA125B, ALA125C, ALA126B, ALA126C, ALA130B, ALA153C, ALA155B, ALA155C, ALA164C, ALA169C, ALA173C, ALA180B, ALA182B, ALA182C, ALA183B, ALA183C, ALA203B, ALA205B, ALA212B, ALA232B, ALA234B, ALA236B, ALA85C, ALA93C, ALA96C, ARG158B, ARG158C, ARG162B, ARG162C, ARG163C, ARG188B, ARG209B, ARG215B, ARG216B, ARG223B, ARG223C, ARG249B, ARG84C, ASN145C, ASN187B, ASN210B, ASN222B, ASN222C, ASP100C, ASP128B, ASP246B, ASP69C, ASP89C, CYS127B, CYS94C, GLN122B, GLN122C, GLN144C, GLN211B, GLN231B, GLU167C, GLU219B, GLU226B, GLU226C, GLU230B, GLU242B, GLU72C, GLU82C, GLU92C, GLY142C, GLY146C, GLY147C, GLY161B, GLY161C, GLY172C, GLY184B, GLY217B, GLY248B, GLY83C, HIS103B, HIS103C, HIS198B, HIS224B, HIS243B, HIS68C, ILE109B, ILE160B, ILE160C, ILE186B, LEU101C, LEU121B, LEU123B, LEU123C, LEU129B, LEU140C, LEU170C, LEU181B, LEU185B, LEU190B, LEU202B, LEU206B, LEU214B, LEU218B, LEU221B, LEU225B, LEU225C, LEU227B, LEU227C, LEU229B, LEU229C, LEU235B, LEU70C, LEU90C, LEU99C, LYS106B, LYS71C, PHE138B, PHE148C, PHE244B, PHE86C, PHE91C, PRO105B, PRO107B, PRO141C, PRO152C, PRO213B, PRO228B, PRO228C, PRO238B, SER157B, SER157C, SER95C, THR108B, THR150C, THR151C, THR166C, THR171C, THR220B, THR237B, THR88C, TRP179C, TYR131B, TYR175C, TYR233B, VAL112B, VAL143C, VAL154B, VAL154C, VAL156B, VAL156C, VAL159B, VAL159C, VAL165C, VAL239B, VAL241B, VAL54B, VAL87C
• B-D: ALA85B, ALA96D, ARG216B, ARG216D, ARG223B, ARG223D, ARG44B, ARG44D, ARG84B, ARG84D, ASP246B, ASP246D, GLU219B, GLU219D, GLU242B, GLU242D, GLU82D, GLU92B, GLU92D, HIS76B, LEU99B, LEU99D, PRO247B, PRO247D, SER95B, SER95D, THR88B, THR88D, VAL241B, VAL241D
• B-E: ARG84B, ARG84E, GLN231B, GLN231E, GLU230B, GLU230E, PRO228B, PRO228E
• B-F: ALA232B, ALA232F, ALA234B, ALA234F, ALA236B, ALA236F, ARG216B, ARG216F, ARG223B, ARG223F, ASN222B, ASN222F, GLN231B, GLN231F, GLU219B, GLU219F, GLU226B, GLU226F, GLU230B, GLU230F, GLU242B, GLU242F, HIS103B, HIS103F, HIS224B, HIS224F, LEU225B, LEU225F, LEU227B, LEU227F, LEU235B, LEU235F, LEU99B, LEU99F, PRO228B, PRO228F, PRO238B, PRO238F, THR220B, THR220F, THR237B, THR237F, TYR233B, TYR233F, VAL239B, VAL239F, VAL241B, VAL241F
• B-G: ALA135B, ALA193B, ALA193G, ALA194B, ALA194G, ALA196B, ALA200G, ALA203G, ALA205G, ALA207G, ALA208G, ALA26B, ALA28B, ARG137B, ARG188G, ARG209G, ARG62B, ASP201G, GLU113B, GLU16G, GLU192B, GLY114B, GLY204G, GLY59B, GLY61B, HIS198G, HIS29B, HIS58B, ILE189G, ILE63B, LEU190G, LEU195B, LEU202G, LEU206G, PRO191B, PRO191G, PRO27B, PRO60B, SER15G, THR197B, THR197G, THR22B, VAL13B, VAL18G
• B-H: ALA135B, ALA136B, ALA136H, ALA173H, ALA177B, ALA177H, ALA193B, ALA194B, ARG137B, ARG137H, ARG62H, ASN145H, ASP176B, ASP176H, ASP178B, ASP178H, CYS139H, GLN144H, GLU167H, GLU192B, GLY146H, GLY172H, ILE115H, ILE189B, ILE63H, LEU181B, LEU190B, PHE138H, PRO134B, PRO141H, PRO191B, SER133B, THR171H, THR174H, TRP179H, TYR175H, VAL143H
• C-D: ARG84C, ARG84D, GLN231C, GLN231D, GLU230C, GLU230D, GLU82C, GLU82D, LEU229C, PRO228C, PRO228D
• C-E: ALA232C, ALA232E, ALA234C, ALA234E, ALA236C, ALA236E, ARG216C, ARG216E, ARG223C, ARG223E, ASN222C, ASN222E, GLN231C, GLN231E, GLU219C, GLU219E, GLU226C, GLU226E, GLU230C, GLU230E, GLU242C, GLU242E, HIS103C, HIS103E, HIS224C, HIS224E, LEU225C, LEU225E, LEU227C, LEU227E, LEU235C, LEU235E, LEU99C, LEU99E, PRO228C, PRO228E, PRO238C, PRO238E, THR220C, THR220E, THR237C, THR237E, TYR233C, TYR233E, VAL239C, VAL239E, VAL241C, VAL241E
• C-F: ALA85C, ARG216C, ARG216F, ARG223C, ARG223F, ARG44C, ARG44F, ARG84C, ARG84F, ASP246C, ASP246F, ASP81C, GLU219C, GLU219F, GLU242C, GLU242F, GLU82C, GLU92C, GLU92F, LEU99F, PRO238C, PRO247C, PRO247F, SER95F, THR88C, THR88F, VAL241C, VAL241F
• D-E: ALA102D, ALA102E, ALA110D, ALA118E, ALA119E, ALA125D, ALA125E, ALA126D, ALA126E, ALA130D, ALA153E, ALA155D, ALA155E, ALA164E, ALA169E, ALA173E, ALA180D, ALA182D, ALA182E, ALA183D, ALA183E, ALA203D, ALA205D, ALA208D, ALA212D, ALA232D, ALA234D, ALA236D, ALA85E, ALA93E, ALA96E, ARG158D, ARG158E, ARG162D, ARG162E, ARG163E, ARG188D, ARG209D, ARG215D, ARG216D, ARG223D, ARG223E, ARG84E, ASN145E, ASN187D, ASN210D, ASN222D, ASN222E, ASP100E, ASP128D, ASP246D, ASP69E, ASP89E, CYS127D, CYS94E, GLN122D, GLN122E, GLN144E, GLN211D, GLN231D, GLU167E, GLU219D, GLU226D, GLU226E, GLU230D, GLU242D, GLU92E, GLY142E, GLY146E, GLY147E, GLY161E, GLY172E, GLY184D, GLY217D, GLY248D, GLY67E, GLY83E, HIS103D, HIS103E, HIS198D, HIS224D, HIS243D, HIS68E, ILE109D, ILE160D, ILE160E, ILE186D, LEU101E, LEU121D, LEU123D, LEU123E, LEU129D, LEU140E, LEU170E, LEU181D, LEU185D, LEU190D, LEU202D, LEU206D, LEU214D, LEU218D, LEU221D, LEU225D, LEU225E, LEU227D, LEU227E, LEU229D, LEU229E, LEU235D, LEU70E, LEU90E, LEU97E, LEU99E, LYS106D, LYS71E, PHE148E, PHE244D, PHE86E, PHE91E, PRO105D, PRO107D, PRO141E, PRO152E, PRO213D, PRO228D, PRO228E, PRO238D, PRO247D, SER157D, SER157E, SER95E, THR108D, THR150E, THR151E, THR166E, THR171E, THR220D, THR237D, THR88E, TRP179E, TYR131D, TYR175E, TYR233D, VAL112D, VAL143E, VAL154E, VAL156D, VAL156E, VAL159D, VAL159E, VAL165E, VAL239D, VAL241D, VAL54D, VAL87E
• D-F: ALA102D, ALA102F, ALA110F, ALA118D, ALA119D, ALA125D, ALA125F, ALA126D, ALA126F, ALA130F, ALA153D, ALA155D, ALA155F, ALA164D, ALA169D, ALA173D, ALA180F, ALA182D, ALA182F, ALA183D, ALA183F, ALA203F, ALA205F, ALA212F, ALA232F, ALA234F, ALA236F, ALA85D, ALA93D, ALA96D, ARG158D, ARG158F, ARG162D, ARG162F, ARG163D, ARG188F, ARG209F, ARG215F, ARG216F, ARG223D, ARG223F, ARG84D, ASN145D, ASN187F, ASN210F, ASN222D, ASN222F, ASP100D, ASP128F, ASP246F, ASP69D, ASP89D, CYS127F, CYS94D, GLN122D, GLN122F, GLN144D, GLN211F, GLN231F, GLU167D, GLU219F, GLU226D, GLU226F, GLU230F, GLU242F, GLU72D, GLU92D, GLY142D, GLY146D, GLY147D, GLY161D, GLY172D, GLY184F, GLY217F, GLY248F, GLY67D, GLY83D, HIS103D, HIS103F, HIS198F, HIS224F, HIS243F, HIS68D, ILE109F, ILE160D, ILE160F, ILE186F, LEU101D, LEU121F, LEU123F, LEU129F, LEU140D, LEU170D, LEU181F, LEU185F, LEU190F, LEU202F, LEU206F, LEU214F, LEU218F, LEU221F, LEU225D, LEU225F, LEU227D, LEU227F, LEU229D, LEU229F, LEU235F, LEU70D, LEU90D, LEU97D, LEU99D, LYS106F, PHE148D, PHE244F, PHE86D, PHE91D, PRO105F, PRO107F, PRO141D, PRO152D, PRO213F, PRO228D, PRO228F, PRO238F, PRO247F, SER157D, SER157F, SER95D, THR108F, THR150D, THR151D, THR166D, THR171D, THR220F, THR237F, THR88D, TRP179D, TYR131F, TYR175D, TYR233F, VAL112F, VAL143D, VAL154D, VAL154F, VAL156D, VAL156F, VAL159D, VAL159F, VAL165D, VAL239F, VAL241F, VAL54F, VAL87D
• E-F: ALA102E, ALA102F, ALA110E, ALA118F, ALA119F, ALA125E, ALA125F, ALA126E, ALA126F, ALA130E, ALA153F, ALA155E, ALA155F, ALA164F, ALA169F, ALA173F, ALA180E, ALA182E, ALA182F, ALA183E, ALA183F, ALA203E, ALA205E, ALA208E, ALA212E, ALA232E, ALA234E, ALA236E, ALA85F, ALA93F, ALA96F, ARG158E, ARG158F, ARG162E, ARG162F, ARG163F, ARG188E, ARG209E, ARG215E, ARG216E, ARG223E, ARG223F, ARG84F, ASN145F, ASN187E, ASN210E, ASN222E, ASN222F, ASP100F, ASP128E, ASP246E, ASP69F, ASP89F, CYS127E, CYS94F, GLN122E, GLN122F, GLN144F, GLN211E, GLN231E, GLU167F, GLU219E, GLU226E, GLU226F, GLU230E, GLU242E, GLU72F, GLU92F, GLY142F, GLY146F, GLY147F, GLY161F, GLY172F, GLY184E, GLY217E, GLY248E, GLY67F, GLY83F, HIS103E, HIS103F, HIS198E, HIS224E, HIS243E, HIS68F, ILE109E, ILE160E, ILE160F, ILE186E, LEU101F, LEU121E, LEU123E, LEU129E, LEU140F, LEU170F, LEU181E, LEU185E, LEU190E, LEU202E, LEU206E, LEU214E, LEU218E, LEU221E, LEU225E, LEU225F, LEU227E, LEU227F, LEU229E, LEU229F, LEU235E, LEU70F, LEU90F, LEU97F, LEU99F, LYS106E, LYS71F, PHE148F, PHE244E, PHE86F, PHE91F, PRO105E, PRO107E, PRO141F, PRO152F, PRO213E, PRO228E, PRO228F, PRO238E, PRO247E, SER157E, SER157F, SER95F, THR108E, THR150F, THR151F, THR166F, THR171F, THR174F, THR220E, THR237E, THR88F, TRP179F, TYR131E, TYR175F, TYR233E, VAL112E, VAL143F, VAL154E, VAL154F, VAL156E, VAL156F, VAL159E, VAL159F, VAL165F, VAL239E, VAL241E, VAL54E, VAL87F
• G-H: ALA102G, ALA102H, ALA110G, ALA118H, ALA119H, ALA125G, ALA125H, ALA126G, ALA126H, ALA130G, ALA153H, ALA155G, ALA155H, ALA164H, ALA169H, ALA173H, ALA180G, ALA182G, ALA182H, ALA183G, ALA183H, ALA203G, ALA205G, ALA208G, ALA212G, ALA232G, ALA234G, ALA236G, ALA85H, ALA93H, ALA96H, ARG158G, ARG158H, ARG162G, ARG162H, ARG163H, ARG188G, ARG209G, ARG215G, ARG216G, ARG223G, ARG223H, ARG84H, ASN145H, ASN187G, ASN210G, ASN222G, ASN222H, ASP100H, ASP128G, ASP246G, ASP69H, ASP89H, CYS127G, CYS94H, GLN122G, GLN122H, GLN144H, GLN211G, GLN231G, GLU167H, GLU219G, GLU226G, GLU226H, GLU230G, GLU242G, GLU72H, GLU82H, GLU92H, GLY142H, GLY146H, GLY147H, GLY161G, GLY161H, GLY172H, GLY184G, GLY217G, GLY248G, GLY67H, GLY83H, HIS103G, HIS103H, HIS198G, HIS224G, HIS243G, HIS68H, ILE109G, ILE160G, ILE160H, ILE186G, LEU101H, LEU121G, LEU123G, LEU123H, LEU129G, LEU140H, LEU170H, LEU181G, LEU185G, LEU190G, LEU202G, LEU206G, LEU214G, LEU218G, LEU221G, LEU225G, LEU225H, LEU227G, LEU227H, LEU229G, LEU229H, LEU235G, LEU70H, LEU90H, LEU97H, LEU99H, LYS106G, LYS71H, PHE148H, PHE244G, PHE86H, PHE91H, PRO105G, PRO107G, PRO141H, PRO152H, PRO213G, PRO228G, PRO228H, PRO238G, PRO247G, SER157G, SER157H, SER95H, THR108G, THR150H, THR151H, THR166H, THR171H, THR220G, THR237G, THR88H, TRP179H, TYR131G, TYR175H, TYR233G, VAL112G, VAL143H, VAL154G, VAL154H, VAL156G, VAL156H, VAL159G, VAL159H, VAL165H, VAL239G, VAL241G, VAL54G, VAL87H
• G-I: ALA102G, ALA102I, ALA110I, ALA118G, ALA119G, ALA125G, ALA125I, ALA126G, ALA126I, ALA130I, ALA153G, ALA155G, ALA155I, ALA164G, ALA169G, ALA173G, ALA180I, ALA182G, ALA182I, ALA183G, ALA183I, ALA203I, ALA205I, ALA208I, ALA212I, ALA232I, ALA234I, ALA236I, ALA85G, ALA93G, ALA96G, ARG158G, ARG158I, ARG162G, ARG162I, ARG163G, ARG188I, ARG209I, ARG215I, ARG216I, ARG223G, ARG223I, ARG84G, ASN145G, ASN187I, ASN210I, ASN222G, ASN222I, ASP100G, ASP128I, ASP246I, ASP69G, ASP89G, CYS127I, CYS94G, GLN122G, GLN122I, GLN144G, GLN211I, GLN231I, GLU167G, GLU219I, GLU226G, GLU226I, GLU230I, GLU242I, GLU72G, GLU92G, GLY142G, GLY146G, GLY147G, GLY161G, GLY161I, GLY172G, GLY184I, GLY217I, GLY248I, GLY83G, HIS103G, HIS103I, HIS198I, HIS224I, HIS243I, HIS68G, ILE109I, ILE160G, ILE160I, ILE186I, LEU101G, LEU121I, LEU123G, LEU123I, LEU129I, LEU140G, LEU170G, LEU181I, LEU185I, LEU190I, LEU202I, LEU206I, LEU214I, LEU218I, LEU221I, LEU225G, LEU225I, LEU227G, LEU227I, LEU229G, LEU229I, LEU235I, LEU70G, LEU90G, LEU97G, LEU99G, LYS106I, LYS71G, PHE148G, PHE244I, PHE86G, PHE91G, PRO105I, PRO107I, PRO141G, PRO152G, PRO213I, PRO228G, PRO228I, PRO238I, PRO247I, SER157G, SER157I, SER95G, THR108I, THR150G, THR151G, THR166G, THR171G, THR174G, THR220I, THR237I, THR88G, TRP179G, TYR131I, TYR175G, TYR233I, VAL143G, VAL154G, VAL156G, VAL156I, VAL159G, VAL159I, VAL165G, VAL239I, VAL241I, VAL54I, VAL87G
• G-J: ARG84G, ARG84J, GLN231G, GLN231J, GLU230G, GLU230J, GLU82G, GLU82J, LEU229G, LEU229J, PRO228G, PRO228J
• G-K: ALA232G, ALA232K, ALA234G, ALA234K, ALA236G, ALA236K, ARG216G, ARG216K, ARG223G, ARG223K, ASN222G, ASN222K, GLN231G, GLN231K, GLU219G, GLU219K, GLU226G, GLU226K, GLU230G, GLU230K, GLU242G, GLU242K, HIS103G, HIS103K, HIS224G, HIS224K, LEU225G, LEU225K, LEU227G, LEU227K, LEU235G, LEU235K, LEU99G, LEU99K, PRO228G, PRO228K, PRO238G, PRO238K, THR220G, THR220K, THR237G, THR237K, TYR233G, TYR233K, VAL239G, VAL239K, VAL241G, VAL241K
• G-L: ARG216G, ARG216L, ARG223G, ARG223L, ARG84G, ARG84L, ASP246G, ASP246L, GLU219G, GLU219L, GLU242G, GLU242L, GLU92G, GLU92L, LEU99G, LEU99L, PRO247G, PRO247L, SER95L, THR88G, THR88L, VAL241G, VAL241L
• H-I: ALA102H, ALA102I, ALA110H, ALA118I, ALA119I, ALA125H, ALA125I, ALA126H, ALA126I, ALA130H, ALA153I, ALA155H, ALA155I, ALA164I, ALA169I, ALA173I, ALA180H, ALA182H, ALA182I, ALA183H, ALA183I, ALA203H, ALA205H, ALA212H, ALA232H, ALA234H, ALA236H, ALA85I, ALA93I, ALA96I, ARG158H, ARG158I, ARG162H, ARG162I, ARG163I, ARG188H, ARG209H, ARG215H, ARG216H, ARG223H, ARG223I, ARG84I, ASN145I, ASN187H, ASN210H, ASN222H, ASN222I, ASP100I, ASP128H, ASP246H, ASP69I, ASP89I, CYS127H, CYS94I, GLN122H, GLN122I, GLN144I, GLN211H, GLN231H, GLU167I, GLU219H, GLU226H, GLU226I, GLU230H, GLU242H, GLU72I, GLU82I, GLU92I, GLY142I, GLY146I, GLY147I, GLY161H, GLY161I, GLY172I, GLY184H, GLY217H, GLY248H, GLY67I, GLY83I, HIS103H, HIS103I, HIS198H, HIS224H, HIS243H, HIS68I, ILE109H, ILE160H, ILE160I, ILE186H, LEU101I, LEU121H, LEU123H, LEU123I, LEU129H, LEU140I, LEU170I, LEU181H, LEU185H, LEU190H, LEU202H, LEU206H, LEU214H, LEU218H, LEU221H, LEU225H, LEU225I, LEU227H, LEU227I, LEU229H, LEU229I, LEU235H, LEU70I, LEU90I, LEU97I, LEU99I, LYS106H, LYS71I, PHE148I, PHE244H, PHE86I, PHE91I, PRO105H, PRO107H, PRO141I, PRO152I, PRO213H, PRO228H, PRO228I, PRO238H, PRO247H, SER157H, SER157I, SER95I, THR108H, THR150I, THR151I, THR166I, THR171I, THR220H, THR237H, THR88I, TRP179I, TYR131H, TYR175I, TYR233H, VAL112H, VAL143I, VAL154I, VAL156H, VAL156I, VAL159H, VAL159I, VAL165I, VAL239H, VAL241H, VAL54H, VAL87I
• H-J: ALA232H, ALA232J, ALA234H, ALA234J, ALA236H, ALA236J, ARG216H, ARG216J, ARG223H, ARG223J, ASN222H, ASN222J, GLN231H, GLN231J, GLU219H, GLU219J, GLU226H, GLU226J, GLU230H, GLU230J, GLU242H, GLU242J, HIS103H, HIS103J, HIS224H, HIS224J, LEU221H, LEU225H, LEU225J, LEU227H, LEU227J, LEU235H, LEU235J, LEU99H, LEU99J, PRO228H, PRO228J, PRO238H, PRO238J, THR220H, THR220J, THR237H, THR237J, TYR233H, TYR233J, VAL239H, VAL239J, VAL241H, VAL241J
• H-K: ALA85K, ARG216H, ARG216K, ARG223H, ARG223K, ARG44H, ARG44K, ARG84H, ARG84K, ASP246H, ASP246K, GLU219H, GLU219K, GLU242H, GLU242K, GLU82K, GLU92H, GLU92K, LEU99H, LEU99K, PRO247H, PRO247K, SER95K, THR88H, THR88K, VAL241H, VAL241K
• H-L: ARG84H, ARG84L, GLN231H, GLN231L, GLU230H, GLU230L, GLU82H, GLU82L, LEU229H, LEU229L, PRO228H, PRO228L
• I-J: ALA85J, ALA96J, ARG216I, ARG216J, ARG223I, ARG223J, ARG84I, ARG84J, ASP246I, ASP246J, GLU219I, GLU219J, GLU242I, GLU242J, GLU92I, GLU92J, LEU99I, LEU99J, PRO247I, PRO247J, SER95I, THR88I, THR88J, VAL241I, VAL241J
• I-K: ARG84I, ARG84K, GLN231I, GLN231K, GLU230I, GLU230K, GLU82I, GLU82K, LEU229I, PRO228I, PRO228K
• I-L: ALA232I, ALA232L, ALA234I, ALA234L, ALA236I, ALA236L, ARG216I, ARG216L, ARG223I, ARG223L, ASN222I, ASN222L, GLN231I, GLN231L, GLU219I, GLU219L, GLU226I, GLU226L, GLU230I, GLU230L, GLU242I, GLU242L, HIS103I, HIS103L, HIS224I, HIS224L, LEU225I, LEU225L, LEU227I, LEU227L, LEU235I, LEU235L, LEU99I, LEU99L, PRO228I, PRO228L, PRO238I, PRO238L, THR220I, THR220L, THR237I, THR237L, TYR233I, TYR233L, VAL239I, VAL239L, VAL241I, VAL241L
• J-K: ALA102J, ALA102K, ALA110J, ALA118K, ALA119K, ALA125J, ALA125K, ALA126J, ALA126K, ALA130J, ALA153K, ALA155J, ALA155K, ALA164K, ALA169K, ALA173K, ALA180J, ALA182J, ALA182K, ALA183J, ALA183K, ALA203J, ALA205J, ALA212J, ALA232J, ALA234J, ALA236J, ALA85K, ALA93K, ALA96K, ARG158J, ARG158K, ARG162J, ARG162K, ARG163K, ARG188J, ARG209J, ARG215J, ARG216J, ARG223J, ARG223K, ARG84K, ASN145K, ASN187J, ASN210J, ASN222J, ASN222K, ASP100K, ASP128J, ASP246J, ASP69K, ASP89K, CYS127J, CYS94K, GLN122J, GLN122K, GLN144K, GLN211J, GLN231J, GLU167K, GLU219J, GLU226J, GLU226K, GLU230J, GLU242J, GLU72K, GLU92K, GLY142K, GLY146K, GLY147K, GLY161J, GLY161K, GLY172K, GLY184J, GLY217J, GLY248J, GLY83K, HIS103J, HIS103K, HIS198J, HIS224J, HIS243J, HIS68K, ILE109J, ILE160J, ILE160K, ILE186J, LEU101K, LEU121J, LEU123J, LEU123K, LEU129J, LEU140K, LEU170K, LEU181J, LEU185J, LEU190J, LEU202J, LEU206J, LEU214J, LEU218J, LEU221J, LEU225J, LEU225K, LEU227J, LEU227K, LEU229J, LEU229K, LEU235J, LEU70K, LEU90K, LEU97K, LEU99K, LYS106J, LYS71K, PHE138J, PHE148K, PHE244J, PHE86K, PHE91K, PRO105J, PRO107J, PRO141K, PRO152K, PRO213J, PRO228J, PRO228K, PRO238J, PRO247J, SER157J, SER157K, SER95K, THR108J, THR150K, THR151K, THR166K, THR171K, THR220J, THR237J, THR88K, TRP179K, TYR131J, TYR175K, TYR233J, VAL112J, VAL143K, VAL154K, VAL156J, VAL156K, VAL159J, VAL159K, VAL165K, VAL239J, VAL241J, VAL54J, VAL87K
• J-L: ALA102J, ALA102L, ALA110L, ALA118J, ALA125J, ALA125L, ALA126J, ALA126L, ALA130L, ALA153J, ALA155J, ALA155L, ALA164J, ALA169J, ALA173J, ALA180L, ALA182J, ALA182L, ALA183J, ALA183L, ALA203L, ALA205L, ALA208L, ALA212L, ALA232L, ALA234L, ALA236L, ALA85J, ALA93J, ALA96J, ARG158J, ARG158L, ARG162J, ARG162L, ARG163J, ARG188L, ARG209L, ARG215L, ARG216L, ARG223J, ARG223L, ARG84J, ASN145J, ASN187L, ASN210L, ASN222J, ASN222L, ASP100J, ASP128L, ASP246L, ASP69J, ASP89J, CYS127L, CYS94J, GLN122J, GLN122L, GLN144J, GLN211L, GLN231L, GLU167J, GLU219L, GLU226J, GLU226L, GLU230L, GLU242L, GLU72J, GLU92J, GLY142J, GLY146J, GLY147J, GLY161J, GLY172J, GLY184L, GLY217L, GLY248L, GLY67J, GLY83J, HIS103J, HIS103L, HIS198L, HIS224L, HIS243L, HIS68J, ILE109L, ILE160J, ILE160L, ILE186L, LEU101J, LEU121L, LEU123J, LEU123L, LEU129L, LEU140J, LEU170J, LEU181L, LEU185L, LEU202L, LEU206L, LEU214L, LEU218L, LEU221L, LEU225J, LEU225L, LEU227J, LEU227L, LEU229J, LEU229L, LEU235L, LEU70J, LEU90J, LEU97J, LEU99J, LYS106L, LYS71J, PHE138L, PHE148J, PHE244L, PHE86J, PHE91J, PRO105L, PRO107L, PRO141J, PRO152J, PRO213L, PRO228J, PRO228L, PRO238L, PRO247L, SER157J, SER157L, SER95J, THR108L, THR150J, THR151J, THR166J, THR171J, THR220L, THR237L, THR88J, TRP179J, TYR131L, TYR175J, TYR233L, VAL112L, VAL143J, VAL154J, VAL156J, VAL156L, VAL159J, VAL159L, VAL165J, VAL239L, VAL241L, VAL54L, VAL87J
• K-L: ALA102K, ALA102L, ALA110K, ALA118L, ALA125K, ALA125L, ALA126K, ALA126L, ALA130K, ALA153L, ALA155K, ALA155L, ALA164L, ALA169L, ALA173L, ALA180K, ALA182K, ALA182L, ALA183K, ALA183L, ALA203K, ALA205K, ALA212K, ALA232K, ALA234K, ALA236K, ALA85L, ALA93L, ALA96L, ARG158K, ARG158L, ARG162K, ARG162L, ARG163L, ARG188K, ARG209K, ARG215K, ARG216K, ARG223K, ARG223L, ARG84L, ASN145L, ASN187K, ASN210K, ASN222K, ASN222L, ASP100L, ASP128K, ASP246K, ASP89L, CYS127K, CYS94L, GLN122K, GLN122L, GLN144L, GLN211K, GLN231K, GLU167L, GLU219K, GLU226K, GLU226L, GLU230K, GLU242K, GLU72L, GLU82L, GLU92L, GLY142L, GLY146L, GLY147L, GLY161K, GLY161L, GLY172L, GLY184K, GLY217K, GLY248K, GLY83L, HIS103K, HIS103L, HIS198K, HIS224K, HIS243K, HIS68L, ILE109K, ILE160K, ILE160L, ILE186K, LEU101L, LEU121K, LEU123K, LEU123L, LEU129K, LEU140L, LEU170L, LEU181K, LEU185K, LEU190K, LEU202K, LEU206K, LEU214K, LEU218K, LEU221K, LEU225K, LEU225L, LEU227K, LEU227L, LEU229K, LEU229L, LEU235K, LEU70L, LEU90L, LEU97L, LEU99L, LYS106K, PHE138K, PHE148L, PHE244K, PHE86L, PHE91L, PRO105K, PRO107K, PRO141L, PRO152L, PRO213K, PRO228K, PRO228L, PRO238K, PRO247K, SER157K, SER157L, SER95L, THR108K, THR150L, THR151L, THR166L, THR171L, THR220K, THR237K, THR88L, TRP179L, TYR131K, TYR175L, TYR233K, VAL112K, VAL143L, VAL154K, VAL154L, VAL156K, VAL156L, VAL159K, VAL159L, VAL165L, VAL239K, VAL241K, VAL54K, VAL87L