3L2G

glycocyamine kinase, beta-beta homodimer from marine worm namalycastis sp., with transition state analog mg(ii)-adp-no3-glycocyamine. part 2.

• Total interactions analyzed: 153
• Total true interactions: 33
• Strongest Interaction:
  • Chains: G-H
  • Int. Res.: 154
  • Norm. En. per Res.: -3.3349
• Hub Node: D(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-90.4342	-41.3157	-369.899	-501.6489	164	24	4	14978	4	77	75
B-C	0.0	-30.4484	-48.4546	-78.903	55	6	0	2825	3	25	27
B-G	-10.3574	14.7621	-51.1163	-46.7116	47	5	0	2723	1	30	29
B-H	-5.1939	-15.0679	-5.8211	-26.0829	9	1	0	173	2	8	7
C-D	-101.05	-30.2891	-367.062	-498.4011	162	24	4	14482	3	78	73
C-H	-21.2071	17.9021	-38.2603	-41.5653	51	12	0	2572	2	30	26
D-E	-6.6755	-1.9366	-39.9284	-48.5405	52	3	0	2110	4	19	19
D-H	0.0	-1.9793	-4.4884	-6.4678	10	0	0	203	1	8	6
D-I	-10.9191	17.3844	-54.7166	-48.2513	51	10	0	2862	0	28	30
D-J	-9.1477	-14.7523	-3.7834	-27.6833	9	1	0	168	2	8	7
E-F	-81.0999	-19.2508	-345.127	-445.4777	156	25	3	14004	3	72	73
E-J	0.0	8.8409	-18.4853	-9.6444	34	3	0	1215	0	19	27
F-K	-16.3824	5.3216	-68.7357	-79.7965	55	6	0	3253	0	35	37
F-L	0.0	5.484	-0.4088	5.0752	8	0	0	87	0	7	6
G-H	-105.6397	-55.2961	-352.639	-513.5748	154	17	3	13870	4	73	71
G-N	0.0	-1.9246	-1.6769	-3.6016	8	0	0	192	0	6	3
G-O	-32.6573	17.7821	-120.736	-135.6112	83	10	0	5373	0	59	56
H-I	-12.9908	-42.7316	-40.9028	-96.6252	50	4	0	2270	4	26	23
H-O	-2.7589	-6.6792	-22.6165	-32.0546	24	0	0	1356	2	6	8
H-P	-27.2092	16.819	-109.087	-119.4772	86	5	0	5230	0	55	56
I-J	-111.9014	-38.1226	-346.224	-496.248	160	24	4	14221	6	76	73
I-P	0.0	5.0054	-0.0638	4.9416	7	0	0	27	0	5	6
I-Q	-45.7648	21.3686	-121.561	-145.9571	89	15	0	5656	0	63	54
J-K	0.0	-5.8983	-15.6437	-21.542	45	0	2	1646	1	22	25
J-Q	0.0	-21.2563	-22.8057	-44.062	22	0	0	1258	5	6	8
J-R	-55.3497	8.5488			22
K-L	-101.185	-43.7305	-333.511	-478.4265	153	27	2	13047	4	74	73
K-R	0.0	-5.1866			4
M-N	-92.5943	-48.1726	-346.364	-487.1309	160	21	3	13953	5	75	74
N-O	-6.9823	-5.3767	-10.8517	-23.2107	40	6	0	1396	1	15	10
O-P	-111.3014	-42.8676	-343.981	-498.15	163	16	3	13967	5	72	79
P-Q	-8.3072	-9.4347	-10.071	-27.8129	30	2	0	797	0	9	10
Q-R	-110.1486	-31.5697			31

Interface residues

• A-B: ALA156A, ALA160A, ALA160B, ALA219A, ALA219B, ALA27A, ALA27B, ALA28A, ALA28B, ARG13B, ARG159A, ARG159B, ARG162A, ARG162B, ARG163A, ARG163B, ARG220A, ARG220B, ARG226A, ARG226B, ASN12B, ASN191A, ASN191B, ASN30A, ASN30B, ASN60A, ASN60B, ASN74A, ASN74B, ASP221A, ASP221B, ASP224A, ASP224B, ASP29A, ASP29B, ASP33A, ASP33B, ASP55A, ASP65A, ASP65B, ASP73A, ASP73B, ASP7B, ASP90A, CB9.72643-9.77260, CYS152A, CYS152B, CYS218A, CYS67A, GLN195A, GLN195B, GLN69A, GLN69B, GLN6B, GLU161A, GLU161B, GLU192A, GLU21B, GLY150A, GLY150B, GLY15B, GLY217A, GLY217B, GLY225A, GLY225B, GLY61A, GLY71A, GLY71B, GLY89A, HIS16B, HIS37A, HIS37B, ILE5B, ILE68A, ILE68B, LEU153A, LEU164A, LEU164B, LEU187A, LEU187B, LEU34A, LEU34B, LEU45A, LEU45B, LYS11B, LYS149A, LYS18B, LYS207A, LYS207B, LYS24A, LYS24A5, LYS24B, LYS26A, LYS26B, LYS36A, LYS36B, LYS56A, LYS66A, LYS66B, LYS78A, LYS78B, MET157A, MET157B, MET190A, MET190B, MET41A, MET41B, PHE25A, PHE25B, PHE31A, PHE31B, PHE64A, PHE64B, PHE9B, PRO155A, PRO186B, PRO19B, PRO223A, PRO223B, PRO32A, PRO32B, PRO59A, PRO75A, PRO75B, SER158A, SER158B, SER17B, SER216A, SER22B, SER35A, SER3B, THR188A, THR188B, THR189A, THR189B, THR214A, THR214B, THR215A, THR215B, THR58A, THR63A, THR70A, THR70B, TRP20B, TRP222A, TRP222B, TRP54A, TRP54B, TYR50A, TYR50B, TYR53A, TYR8B, TYR97A, VAL10B, VAL148A, VAL14B, VAL151A, VAL151B, VAL165A, VAL165B, VAL57A, VAL62A, VAL72A, VAL72B
• B-C: ALA119C, ALA373B, ARG358B, ARG358C, ASN125B, ASN125C, ASN369B, ASP115C, ASP121C, ASP123C, ASP366B, ASP366C, ASP386B, GLN362B, GLN362C, GLU133B, GLU359C, GLY129B, GLY129C, GLY130B, GLY354C, GLY367B, HIS117C, HIS124C, ILE372B, ILE388B, LEU127B, LEU127C, LEU326B, LEU328B, LEU360C, LEU370B, LYS116C, LYS126B, LYS126C, LYS258C, LYS355C, LYS376B, LYS377B, LYS390B, MET387B, PHE111C, PHE132B, PRO118C, PRO389B, SER114C, SER356C, VAL128B, VAL128C, VAL131B, VAL131C, VAL363B, VAL363C, VAL365B, VAL368B
• B-G: ALA181G, ALA42B, ARG266G, ARG273G, ARG318B, ASN231G, ASN232G, ASN38B, ASN39B, ASP171G, ASP179G, GLN44B, GLU106B, GLU107B, GLU233G, GLU270G, GLU321B, GLU48B, GLU99B, GLY174G, GLY175G, GLY178G, GLY182G, HIS37B, ILE388B, LEU176G, LEU180G, LEU34B, LEU45B, LEU49B, LYS103B, LYS112B, LYS167G, LYS177G, LYS183G, LYS325B, LYS36B, LYS390B, LYS47B, LYS82B, MET41B, PHE31B, SER35B, SER43B, THR46B, TYR185G, VAL40B
• B-H: ALA28H, ARG318B, ASP29H, ASP385B, ASP386B, ILE384B, LYS26H, LYS390B, SER383B
• C-D: ALA156C, ALA160C, ALA160D, ALA219C, ALA219D, ALA27C, ALA27D, ALA28C, ALA28D, ARG13D, ARG159C, ARG159D, ARG162C, ARG162D, ARG163C, ARG163D, ARG220C, ARG220D, ARG226C, ARG226D, ASN12D, ASN191C, ASN191D, ASN30C, ASN30D, ASN60C, ASN60D, ASN74C, ASN74D, ASP221C, ASP221D, ASP224C, ASP224D, ASP29C, ASP29D, ASP33C, ASP33D, ASP55C, ASP65C, ASP65D, ASP73C, ASP73D, ASP90C, CYS152C, CYS152D, CYS218C, CYS67C, GLN195C, GLN195D, GLN69C, GLN69D, GLN6D, GLU161C, GLU161D, GLU192C, GLU192D, GLU21D, GLY150C, GLY150D, GLY15D, GLY217C, GLY217D, GLY225C, GLY225D, GLY61C, GLY71C, GLY89C, HIS16D, HIS37C, HIS37D, ILE68C, ILE68D, LEU153C, LEU164C, LEU164D, LEU187C, LEU187D, LEU34C, LEU34D, LEU45C, LEU45D, LYS11D, LYS149C, LYS18D, LYS207C, LYS207D, LYS24C, LYS24D, LYS26C, LYS26D, LYS36C, LYS36D, LYS56C, LYS66C, LYS66D, LYS78C, LYS78D, MET157C, MET157D, MET190C, MET190D, MET41C, MET41D, PHE25C, PHE25D, PHE31C, PHE31D, PHE64C, PHE64D, PHE9D, PRO154C, PRO155C, PRO19D, PRO223C, PRO223D, PRO32C, PRO32D, PRO59C, PRO75C, PRO75D, SER158C, SER158D, SER17D, SER216C, SER22D, SER35C, SER35D, THR188C, THR188D, THR189C, THR189D, THR209C, THR214C, THR214D, THR215C, THR215D, THR58C, THR63C, THR63D, THR70C, THR70D, TRP20D, TRP222C, TRP222D, TRP54C, TRP54D, TYR50C, TYR50D, TYR53C, TYR8D, TYR97C, VAL10D, VAL148C, VAL14D, VAL151C, VAL151D, VAL165C, VAL165D, VAL57C, VAL62C, VAL72C, VAL72D
• C-H: ALA181C, ALA42H, ARG266C, ARG273C, ARG318H, ASN232C, ASN38H, ASN39H, ASP171C, ASP179C, GLN44H, GLU106H, GLU107H, GLU233C, GLU270C, GLU277C, GLU321H, GLU48H, GLU99H, GLY174C, GLY175C, GLY178C, HIS110H, HIS37H, ILE388H, LEU176C, LEU180C, LEU34H, LEU45H, LEU49H, LYS103H, LYS112H, LYS167C, LYS177C, LYS183C, LYS325H, LYS36H, LYS390H, LYS47H, LYS82H, MET41H, PHE100H, PHE31H, PRO113H, PRO389H, SER262C, SER35H, SER43H, THR46H, TYR185C, VAL40H
• D-E: ALA119E, ALA373D, ARG358D, ARG358E, ASN125D, ASN125E, ASN369D, ASP115E, ASP121E, ASP123E, ASP366D, ASP366E, ASP386D, GLN362D, GLN362E, GLU133D, GLU359E, GLY129D, GLY129E, GLY130D, GLY354E, GLY367D, HIS117E, ILE372D, LEU127D, LEU127E, LEU326D, LEU360E, LEU370D, LYS116E, LYS126D, LYS126E, LYS258D, LYS258E, LYS355E, LYS376D, LYS377D, LYS390D, MET387D, PHE111E, PHE132D, PRO118E, PRO389D, SER114E, SER356E, VAL128D, VAL128E, VAL131E, VAL363D, VAL363E, VAL365D, VAL368D
• D-H: ALA28D, ARG318H, ASP29D, ASP385H, ASP386H, ILE384H, LYS26D, LYS390H, LYS47D, SER383H
• D-I: ALA181I, ALA42D, ARG266I, ARG273I, ARG318D, ASN231I, ASN232I, ASN38D, ASN39D, ASP171I, ASP179I, GLN44D, GLU106D, GLU107D, GLU233I, GLU270I, GLU277I, GLU321D, GLU48D, GLU99D, GLY174I, GLY175I, GLY178I, GLY182I, HIS110D, HIS37D, ILE388D, LEU176I, LEU180I, LEU34D, LEU45D, LEU49D, LYS103D, LYS112D, LYS167I, LYS177I, LYS183I, LYS325D, LYS36D, LYS390D, LYS47D, LYS82D, MET41D, PHE31D, PRO389D, PRO75D, SER35D, SER43D, THR46D, TYR185I, VAL40D
• D-J: ALA28J, ARG318D, ASP29J, ASP385D, ASP386D, LYS26J, LYS390D, LYS47J, SER383D
• E-F: ALA156E, ALA160E, ALA160F, ALA219E, ALA219F, ALA27E, ALA27F, ALA28E, ALA28F, ARG13F, ARG159E, ARG159F, ARG162E, ARG162F, ARG163E, ARG163F, ARG220E, ARG220F, ARG226E, ARG226F, ASN12F, ASN191E, ASN30E, ASN30F, ASN60E, ASN60F, ASN74E, ASN74F, ASP221E, ASP221F, ASP224E, ASP224F, ASP29E, ASP29F, ASP33E, ASP33F, ASP55E, ASP65E, ASP65F, ASP73E, ASP73F, ASP90E, CYS152E, CYS152F, CYS218E, CYS67E, GLN195F, GLN69E, GLN69F, GLU161E, GLU161F, GLU192E, GLU21F, GLY150E, GLY150F, GLY15F, GLY217E, GLY217F, GLY225F, GLY61E, GLY71E, GLY71F, GLY89E, HIS16F, HIS37E, HIS37F, ILE68E, ILE68F, LEU153E, LEU164E, LEU164F, LEU187E, LEU187F, LEU34E, LEU34F, LEU45E, LEU45F, LYS11F, LYS149E, LYS149F, LYS18F, LYS207E, LYS207F, LYS24E, LYS24F, LYS26E, LYS26F, LYS36E, LYS36F, LYS47E, LYS56E, LYS66E, LYS66F, LYS78E, LYS78F, MET157E, MET157F, MET190E, MET190F, MET41E, MET41F, PHE25E, PHE25F, PHE31E, PHE31F, PHE64E, PHE64F, PHE9F, PRO154E, PRO155E, PRO19F, PRO223E, PRO223F, PRO32E, PRO32F, PRO59E, PRO75E, PRO75F, SER158E, SER158F, SER17F, SER216E, SER22F, SER35E, THR188E, THR188F, THR189E, THR189F, THR209E, THR214E, THR214F, THR215E, THR215F, THR58E, THR63E, THR70E, THR70F, TRP20F, TRP222E, TRP222F, TRP54E, TRP54F, TYR50E, TYR50F, TYR53E, TYR97E, VAL10F, VAL14F, VAL151E, VAL151F, VAL165E, VAL165F, VAL57E, VAL62E, VAL72E, VAL72F
• E-J: ALA181E, ALA42J, ARG318J, ASN232E, ASN38J, ASN39J, ASP171E, ASP179E, GLN44J, GLU106J, GLU107J, GLU233E, GLU321J, GLY178E, HIS110J, HIS37J, ILE388J, LEU176E, LEU180E, LEU45J, LYS103J, LYS112J, LYS167E, LYS177E, LYS183E, LYS325J, LYS390J, LYS82J, PRO113J, PRO389J, SER43J, THR46J, TYR185E, VAL40J
• F-K: ALA181K, ALA42F, ARG263K, ARG266K, ARG273K, ARG318F, ASN231K, ASN232K, ASN235K, ASN38F, ASN39F, ASP171K, ASP179K, ASP33F, CYS104F, GLN44F, GLU106F, GLU107F, GLU233K, GLU270K, GLU321F, GLU48F, GLY174K, GLY175K, GLY178K, GLY182K, GLY76F, HIS110F, HIS37F, LEU176K, LEU180K, LEU34F, LEU45F, LEU49F, LYS103F, LYS112F, LYS167K, LYS177K, LYS183K, LYS325F, LYS36F, LYS390F, LYS47F, LYS82F, MET41F, PHE31F, PRO186K, PRO317F, PRO75F, SER35F, SER43F, THR189K, THR46F, TYR185K, VAL40F
• F-L: ALA28L, ASP29L, ASP385F, ASP386F, LYS26L, LYS390F, LYS47L, SER383F
• G-H: ALA156G, ALA160G, ALA160H, ALA219G, ALA219H, ALA27G, ALA27H, ALA28G, ALA28H, ARG13H, ARG159G, ARG159H, ARG162G, ARG162H, ARG163G, ARG163H, ARG220G, ARG220H, ARG226G, ARG226H, ASN12H, ASN191G, ASN30G, ASN30H, ASN60G, ASN60H, ASN74G, ASN74H, ASP221G, ASP221H, ASP224G, ASP224H, ASP29G, ASP29H, ASP33G, ASP33H, ASP55G, ASP65G, ASP65H, ASP73G, ASP73H, ASP90G, CYS152G, CYS152H, CYS218G, CYS67G, GLN195H, GLN69G, GLN69H, GLU161G, GLU161H, GLU192G, GLU21H, GLY150G, GLY150H, GLY15H, GLY217G, GLY217H, GLY225G, GLY61G, GLY71H, GLY89G, HIS16H, HIS37G, HIS37H, ILE68G, ILE68H, LEU153G, LEU164G, LEU164H, LEU187G, LEU187H, LEU34G, LEU34H, LEU45G, LEU45H, LYS11H, LYS149G, LYS18H, LYS207G, LYS207H, LYS24G, LYS24H, LYS26G, LYS26H, LYS36G, LYS36H, LYS56G, LYS66G, LYS66H, LYS78G, LYS78H, MET157G, MET157H, MET190G, MET190H, MET41H, PHE25G, PHE25H, PHE31G, PHE31H, PHE64G, PHE64H, PHE9H, PRO154G, PRO155G, PRO186H, PRO19H, PRO223G, PRO223H, PRO32G, PRO32H, PRO59G, PRO75G, PRO75H, SER158G, SER158H, SER17H, SER216G, SER22H, SER35G, SER35H, THR188G, THR188H, THR189G, THR189H, THR214G, THR214H, THR215G, THR215H, THR58G, THR63G, THR70G, THR70H, TRP20H, TRP222G, TRP222H, TRP54G, TRP54H, TYR50G, TYR50H, TYR53G, TYR92H, TYR97G, VAL10H, VAL14H, VAL151G, VAL151H, VAL165G, VAL165H, VAL57G, VAL62G, VAL72G, VAL72H
• G-N: ALA380N, ASP386G, ASP386N, GLN382N, GLY381N, LYS377N, LYS390G, SER383N
• G-O: ALA181O, ALA259O, ALA42G, ARG263O, ARG318G, ASN191O, ASN231O, ASN232O, ASN235O, ASN38G, ASN39G, ASN77G, ASP134O, ASP171O, ASP179O, ASP194O, ASP256O, ASP320G, ASP33G, ASP385G, ASP386G, GLN252O, GLN382G, GLN44G, GLU106G, GLU107G, GLU133O, GLU233O, GLU321G, GLY174O, GLY178O, GLY182O, GLY254O, GLY255O, GLY324G, GLY76G, HIS110G, HIS230O, HIS316G, HIS37G, ILE108G, ILE384G, ILE388G, LEU187O, LEU198O, LEU34G, LEU378G, LEU45G, LYS103G, LYS112G, LYS135O, LYS138O, LYS167O, LYS177O, LYS183O, LYS234O, LYS253O, LYS325G, LYS36G, LYS390G, LYS47G, LYS82G, MET190O, MET41G, PHE132O, PHE319G, PRO186O, PRO317G, PRO389G, PRO75G, SER139O, SER35G, SER383G, SER43G, THR188O, THR189O, THR46G, TYR184O, TYR185O, VAL131O, VAL137O, VAL260O, VAL40G
• H-I: ALA373H, ARG358H, ARG358I, ASN125H, ASN125I, ASN369H, ASP115I, ASP121I, ASP123I, ASP366H, ASP366I, ASP386H, GLN362H, GLN362I, GLN382H, GLU133H, GLU359I, GLY129H, GLY129I, GLY130H, GLY354I, GLY367H, ILE372H, LEU127H, LEU127I, LEU326H, LEU360I, LEU370H, LYS116I, LYS126H, LYS126I, LYS258I, LYS355H, LYS355I, LYS376H, LYS377H, LYS390H, MET387H, PHE132H, PRO118I, PRO389H, SER356I, VAL128H, VAL128I, VAL131H, VAL131I, VAL363H, VAL363I, VAL365H, VAL368H
• H-O: ASN191H, ASN191O, ASP194H, ASP194O, GLN195H, GLN195O, GLU192H, GLU192O, GLU196H, GLU196O, LEU187H, LEU187O, LYS193H, LYS193O, LYS207H, LYS207O, MET190H, MET190O, PRO223H, PRO223O, THR188H, THR188O, THR189H, THR189O
• H-P: ALA181H, ALA259H, ALA42P, ARG263H, ARG318P, ASN191H, ASN231H, ASN232H, ASN235H, ASN38P, ASN39P, ASN77P, ASP134H, ASP171H, ASP179H, ASP194H, ASP256H, ASP320P, ASP33P, ASP385P, ASP386P, GLN252H, GLN382P, GLN44P, GLU106P, GLU107P, GLU133H, GLU192H, GLU233H, GLU321P, GLY174H, GLY178H, GLY182H, GLY254H, GLY255H, GLY324P, GLY76P, HIS110P, HIS230H, HIS316P, HIS37P, ILE108P, ILE384P, ILE388P, LEU187H, LEU198H, LEU34P, LEU378P, LEU45P, LYS103P, LYS112P, LYS135H, LYS138H, LYS167H, LYS177H, LYS183H, LYS234H, LYS253H, LYS325P, LYS36P, LYS390P, LYS47P, LYS82P, MET190H, MET322P, MET41P, PHE132H, PHE319P, PRO186H, PRO317P, PRO389P, PRO75P, SER139H, SER35P, SER383P, SER43P, THR188H, THR189H, THR46P, TRP350P, TYR184H, TYR185H, VAL131H, VAL137H, VAL260H, VAL40P
• I-J: ALA156I, ALA160I, ALA160J, ALA219I, ALA219J, ALA27I, ALA27J, ALA28I, ALA28J, ARG13J, ARG159I, ARG159J, ARG162I, ARG162J, ARG163I, ARG163J, ARG220I, ARG220J, ARG226I, ARG226J, ASN12J, ASN191I, ASN191J, ASN30I, ASN30J, ASN60I, ASN60J, ASN74I, ASN74J, ASP221I, ASP221J, ASP224I, ASP224J, ASP29I, ASP29J, ASP33I, ASP33J, ASP55I, ASP65I, ASP65J, ASP73I, ASP73J, ASP7J, ASP90I, CYS152I, CYS152J, CYS67I, GLN195J, GLN69I, GLN69J, GLN6J, GLU161I, GLU161J, GLU192I, GLU192J, GLU21J, GLY150I, GLY150J, GLY15J, GLY217I, GLY217J, GLY225I, GLY225J, GLY61I, GLY71I, GLY71J, GLY89I, HIS16J, HIS37I, HIS37J, ILE68I, ILE68J, LEU153I, LEU164I, LEU164J, LEU187I, LEU187J, LEU34I, LEU34J, LEU45I, LEU45J, LYS11J, LYS149I, LYS18J, LYS207I, LYS207J, LYS24I, LYS24J, LYS26I, LYS26J, LYS36I, LYS36J, LYS56I, LYS66I, LYS66J, LYS78I, LYS78J, MET157I, MET157J, MET190I, MET190J, MET41I, MET41J, PHE25I, PHE25J, PHE31I, PHE31J, PHE64I, PHE64J, PHE9J, PRO154I, PRO155I, PRO19J, PRO223I, PRO223J, PRO32I, PRO32J, PRO59I, PRO75I, PRO75J, SER158I, SER158J, SER17J, SER216I, SER22J, SER35I, SER35J, THR188I, THR188J, THR189I, THR189J, THR214I, THR214J, THR215I, THR215J, THR58I, THR63I, THR63J, THR70I, THR70J, TRP20J, TRP222I, TRP222J, TRP54I, TRP54J, TYR50I, TYR50J, TYR53I, TYR8J, TYR97I, VAL10J, VAL14J, VAL151I, VAL151J, VAL165I, VAL165J, VAL57I, VAL62I, VAL72I, VAL72J
• I-P: ASP386I, ASP386P, GLN382I, GLN382P, LYS377I, LYS377P, MET387P
• I-Q: ALA181Q, ALA259Q, ALA42I, ARG263Q, ARG318I, ARG327I, ASN191Q, ASN231Q, ASN232Q, ASN235Q, ASN38I, ASN39I, ASN77I, ASP134Q, ASP171Q, ASP179Q, ASP194Q, ASP256Q, ASP320I, ASP33I, ASP385I, ASP386I, CYS140Q, GLN252Q, GLN382I, GLN44I, GLU106I, GLU107I, GLU133Q, GLU233Q, GLU321I, GLY174Q, GLY178Q, GLY182Q, GLY254Q, GLY255Q, GLY324I, GLY76I, HIS110I, HIS230Q, HIS316I, HIS37I, ILE108I, ILE384I, ILE388I, LEU187Q, LEU198Q, LEU34I, LEU378I, LEU45I, LYS103I, LYS112I, LYS135Q, LYS138Q, LYS167Q, LYS177Q, LYS183Q, LYS234Q, LYS253Q, LYS315I, LYS325I, LYS36I, LYS390I, LYS47I, LYS82I, MET190Q, MET322I, MET387I, MET41I, PHE132Q, PHE319I, PRO186Q, PRO317I, PRO389I, PRO75I, SER139Q, SER35I, SER383I, SER43I, THR188Q, THR189Q, THR46I, TRP350I, TYR184Q, TYR185Q, VAL131Q, VAL137Q, VAL260Q, VAL40I
• J-K: ALA373J, ARG358K, ASN125K, ASN369J, ASN369K, ASP115K, ASP123K, ASP366J, ASP366K, ASP386J, CYS374J, GLN362J, GLN362K, GLN382J, GLU359K, GLY129J, GLY129K, GLY367J, HIS124K, ILE372J, ILE388J, LEU127K, LEU326J, LEU370J, LEU371J, LYS112K, LYS116K, LYS126J, LYS126K, LYS258K, LYS325J, LYS355K, LYS376J, LYS377J, LYS390J, MET387J, PRO389J, SER114K, SER356K, VAL128J, VAL128K, VAL131K, VAL363K, VAL365J, VAL368J
• J-Q: ASN191J, ASN191Q, ASP194J, ASP194Q, GLN195J, GLN195Q, GLU192J, GLU192Q, GLU196J, GLU196Q, LEU187Q, LYS193J, LYS193Q, LYS207J, LYS207Q, MET190J, MET190Q, PRO223Q, THR188J, THR188Q, THR189J, THR189Q
• J-R: ARG318R, ASN232J, ASP134J, ASP194J, ASP256J, ASP385R, ASP386R, GLU106R, GLU107R, GLU233J, GLU321R, HIS316R, HIS37R, LEU34R, LYS177J, LYS183J, LYS253J, LYS325R, LYS36R, LYS390R, SER35R, THR189J
• K-L: ALA156K, ALA160K, ALA160L, ALA219K, ALA219L, ALA27K, ALA27L, ALA28K, ALA28L, ARG13L, ARG159K, ARG159L, ARG162K, ARG162L, ARG163K, ARG163L, ARG220K, ARG220L, ARG226K, ARG226L, ASN12L, ASN191K, ASN191L, ASN30K, ASN30L, ASN60K, ASN60L, ASN74K, ASN74L, ASP221K, ASP221L, ASP224K, ASP224L, ASP29K, ASP29L, ASP33K, ASP33L, ASP55K, ASP65K, ASP65L, ASP73K, ASP73L, ASP90K, CYS152K, CYS152L, CYS67K, GLN195K, GLN69K, GLN69L, GLU161K, GLU161L, GLU192K, GLU21L, GLY150K, GLY150L, GLY15L, GLY217K, GLY217L, GLY225K, GLY225L, GLY61K, GLY71L, GLY89K, HIS16L, HIS37K, HIS37L, ILE68K, ILE68L, LEU153K, LEU164K, LEU164L, LEU187K, LEU187L, LEU34K, LEU34L, LEU45K, LEU45L, LYS11L, LYS149K, LYS149L, LYS18L, LYS207K, LYS24K, LYS24L, LYS26K, LYS26L, LYS36K, LYS36L, LYS47K, LYS66K, LYS66L, LYS78L, MET157K, MET157L, MET190K, MET190L, MET41K, MET41L, PHE25K, PHE25L, PHE31K, PHE31L, PHE64K, PHE64L, PRO154K, PRO155K, PRO19L, PRO223K, PRO223L, PRO32K, PRO32L, PRO59K, PRO75K, PRO75L, SER158K, SER158L, SER17L, SER216K, SER22L, SER35K, SER35L, THR188K, THR188L, THR189K, THR189L, THR209K, THR214K, THR214L, THR215K, THR215L, THR58K, THR63K, THR63L, THR70K, THR70L, TRP20L, TRP222K, TRP222L, TRP54K, TRP54L, TYR50K, TYR50L, VAL10L, VAL148K, VAL14L, VAL151K, VAL151L, VAL165K, VAL165L, VAL57K, VAL62K, VAL72K, VAL72L
• K-R: ASP386K, ASP386R, LYS377R, LYS390K
• M-N: ALA156M, ALA160M, ALA160N, ALA219M, ALA219N, ALA27M, ALA27N, ALA28M, ALA28N, ARG13N, ARG159M, ARG159N, ARG162M, ARG162N, ARG163M, ARG163N, ARG220M, ARG220N, ARG226M, ARG226N, ASN12N, ASN191M, ASN191N, ASN30M, ASN30N, ASN60M, ASN60N, ASN74M, ASN74N, ASP221M, ASP221N, ASP224M, ASP224N, ASP29M, ASP29N, ASP33M, ASP33N, ASP55M, ASP65M, ASP65N, ASP73M, ASP73N, ASP90M, CYS152M, CYS152N, CYS218M, CYS67M, GLN195N, GLN69M, GLN69N, GLU161M, GLU161N, GLU192M, GLU192N, GLU21N, GLY150M, GLY150N, GLY15N, GLY217M, GLY217N, GLY225M, GLY225N, GLY61M, GLY71M, GLY71N, GLY89M, HIS16N, HIS37M, HIS37N, ILE68M, ILE68N, LEU153M, LEU164M, LEU164N, LEU187M, LEU187N, LEU34M, LEU34N, LEU45M, LEU45N, LYS11N, LYS149M, LYS18N, LYS207M, LYS207N, LYS24M, LYS24N, LYS26M, LYS26N, LYS36M, LYS36N, LYS56M, LYS66M, LYS66N, LYS78M, LYS78N, MET157M, MET157N, MET190M, MET190N, MET41M, MET41N, PHE25M, PHE25N, PHE31M, PHE31N, PHE64M, PHE64N, PHE9N, PRO155M, PRO186N, PRO19N, PRO208N, PRO223M, PRO223N, PRO32M, PRO32N, PRO59M, PRO75M, PRO75N, SER158M, SER158N, SER17N, SER216M, SER22N, SER35M, SER35N, THR188M, THR188N, THR189M, THR189N, THR214M, THR214N, THR215M, THR215N, THR58M, THR63M, THR70M, THR70N, TRP20N, TRP222M, TRP222N, TRP54M, TRP54N, TYR50M, TYR50N, TYR53M, TYR92N, TYR97M, VAL10N, VAL148M, VAL14N, VAL151M, VAL151N, VAL165M, VAL165N, VAL57M, VAL62M, VAL72M, VAL72N
• N-O: ALA373N, ARG358O, ASN125O, ASN369N, ASP121O, ASP123O, ASP256O, ASP366N, ASP386N, GLN362N, GLN362O, GLN382N, GLU133N, GLU359O, GLY129N, GLY129O, GLY130N, GLY367N, ILE372N, LEU127N, LEU127O, LEU326N, LEU370N, LYS126N, LYS126O, LYS258O, LYS376N, LYS377N, LYS390N, MET387N, PHE132N, PRO118O, PRO389N, SER356O, VAL128N, VAL128O, VAL131N, VAL131O, VAL363N, VAL365N
• O-P: ALA156O, ALA160O, ALA160P, ALA219O, ALA219P, ALA27O, ALA27P, ALA28O, ALA28P, ARG13P, ARG159O, ARG159P, ARG162O, ARG162P, ARG163O, ARG163P, ARG220O, ARG220P, ARG226O, ARG226P, ASN12P, ASN191O, ASN191P, ASN30O, ASN30P, ASN60O, ASN60P, ASN74O, ASN74P, ASP221O, ASP221P, ASP224O, ASP224P, ASP29O, ASP29P, ASP33O, ASP33P, ASP55O, ASP65O, ASP65P, ASP73O, ASP73P, ASP90O, CYS152O, CYS152P, CYS218O, CYS67O, GLN195O, GLN195P, GLN69O, GLN69P, GLU161O, GLU161P, GLU192O, GLU192P, GLU21P, GLY150O, GLY150P, GLY15P, GLY217O, GLY217P, GLY225O, GLY225P, GLY61O, GLY71O, GLY71P, GLY89O, HIS16P, HIS37O, HIS37P, ILE68O, ILE68P, LEU153O, LEU164O, LEU164P, LEU187O, LEU187P, LEU34O, LEU34P, LEU45O, LEU45P, LYS11P, LYS149O, LYS18P, LYS207O, LYS207P, LYS24O, LYS24P, LYS26O, LYS26P, LYS36O, LYS36P, LYS56O, LYS66O, LYS66P, LYS78O, LYS78P, MET157O, MET157P, MET190O, MET190P, MET41O, MET41P, PHE25O, PHE25P, PHE31O, PHE31P, PHE64O, PHE64P, PHE9P, PRO154O, PRO155O, PRO19P, PRO208O, PRO208P, PRO223O, PRO223P, PRO32O, PRO32P, PRO59O, PRO75O, PRO75P, SER158O, SER158P, SER17P, SER216O, SER22P, SER35O, SER35P, THR188O, THR188P, THR189O, THR189P, THR209O, THR209P, THR214O, THR214P, THR215O, THR215P, THR58O, THR63O, THR63P, THR70O, THR70P, TRP20P, TRP222O, TRP222P, TRP54O, TRP54P, TYR50O, TYR50P, TYR53O, TYR97O, VAL10P, VAL14P, VAL151O, VAL151P, VAL165O, VAL165P, VAL57O, VAL62O, VAL72O, VAL72P
• P-Q: ARG327Q, ARG358P, ASN125P, ASN125Q, ASP115P, ASP121P, ASP123P, ASP366P, ASP366Q, GLN362P, GLU359P, GLY129Q, GLY130Q, GLY354P, LEU127P, LEU127Q, LEU326Q, LEU360P, LYS116P, LYS126P, LYS126Q, LYS355P, LYS355Q, PHE132Q, PRO118P, SER356P, VAL128P, VAL128Q, VAL131Q, VAL363P
• Q-R: ALA160Q, ALA160R, ARG13R, ARG159Q, ARG159R, ARG163Q, ARG163R, ARG220Q, ARG220R, ASN30Q, ASN30R, ASP221Q, ASP221R, ASP224Q, ASP224R, ASP29Q, ASP29R, ASP33Q, ASP33R, ASP65Q, ASP65R, ASP73Q, ASP73R, GLN69Q, GLU161Q, HIS16R, LYS24R, LYS36Q, LYS66Q, PHE31R, TYR50R