3L2F

glycocyamine kinase, beta-beta homodimer from marine worm namalycastis sp., with transition state analog mg(ii)-adp-no3-glycocyamine. part 1.

• Total interactions analyzed: 153
• Total true interactions: 37
• Strongest Interaction:
  • Chains: A-B
  • Int. Res.: 159
  • Norm. En. per Res.: -3.3866
• Hub Node: I(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-130.6393	-19.2758	-388.561	-538.4761	159	27	4	14661	2	73	67
A-D	0.0	-1.265	-31.5607	-32.8257	49	0	0	1994	1	22	20
A-H	-12.3942	10.2267	-26.2027	-28.3701	42	4	0	1671	1	22	25
B-H	0.0	-5.2692	-0.7945	-6.0637	6	0	0	101	0	6	3
C-D	-86.7014	-46.4572	-326.95	-460.1086	154	18	3	13768	4	73	73
C-F	-6.4526	-1.0168	-36.9777	-44.4471	50	0	0	2058	2	22	21
C-J	0.0	8.7598	-20.2484	-11.4886	37	1	0	1319	0	19	28
D-G	-8.8838	-7.1187	-68.2082	-84.2107	58	1	0	3330	1	36	35
D-H	0.0	5.2339	-1.1307	4.1032	8	0	0	116	0	8	7
D-J	0.0	0.0	-0.0018	-0.0018	2	0	0	2	0	4	2
E-F	-104.6121	-46.7246	-343.206	-494.5427	162	17	4	14216	2	76	74
E-L	-16.2452	12.938	-45.4836	-48.7908	50	5	0	2474	1	30	29
F-I	0.0	12.648	-47.1209	-34.4729	48	1	0	2577	0	30	28
F-J	0.0	0.9439	-4.1601	-3.2162	9	0	0	165	1	8	7
F-L	-2.2672	-6.0787	-6.8222	-15.1681	9	0	0	222	2	8	7
G-H	-91.1554	-36.0875	-350.484	-477.7269	155	23	4	14212	4	73	74
G-J	0.0	-22.6638	-21.5934	-44.2572	49	0	2	1885	0	23	25
G-M	-31.3034	-12.8487	-90.2749	-134.427	81	6	0	4673	2	53	52
G-P	0.0	-3.7849	-1.5045	-5.2894	9	0	0	184	0	5	4
H-M	-6.0785	-4.1272	-45.6851	-55.8908	20	5	0	1747	5	6	10
H-N	0.0	28.7104	-19.6646	9.0458	41	0	0	1385	0	28	26
I-J	-110.3222	-34.471	-346.053	-490.8463	158	22	4	13788	4	73	68
I-L	-9.6964	-42.3033	-35.6406	-87.6403	49	3	0	2148	4	24	23
I-O	-61.0202	11.4479	-111.789	-161.3613	88	16	0	5406	0	60	54
I-P	0.0	0.0	-0.0011	-0.0011	2	0	0	3	0	0	1
I-R	0.0	4.7217			2
J-O	-7.6979	-24.1338	-23.3671	-55.1988	24	0	0	1238	4	6	8
J-P	-39.1118	20.8725	-114.325	-132.5643	88	9	0	5289	0	61	56
K-L	-110.8714	-31.97	-376.571	-519.4124	161	18	4	14277	3	77	73
K-Q	-44.9932	15.7382	-118.919	-148.174	81	12	0	5515	1	60	56
L-Q	-13.5241	-5.612	-27.1777	-46.3138	24	0	0	1415	4	6	8
L-R	-26.677	5.9338			19
M-N	-92.6654	-27.2066	-344.558	-464.43	159	22	3	13887	3	73	75
M-P	-14.9825	-30.3388	-52.8805	-98.2018	55	5	0	2967	4	32	33
O-P	-116.5141	-25.3854	-331.506	-473.4055	154	15	2	12733	3	72	67
O-R	-5.6239	-6.9181			5
Q-R	-96.0232	-29.2498			29

Interface residues

• A-B: ALA156A, ALA160A, ALA160B, ALA219A, ALA219B, ALA27A, ALA27B, ALA28A, ALA28B, ARG13B, ARG159A, ARG159B, ARG162A, ARG162B, ARG163A, ARG163B, ARG220A, ARG220B, ARG226A, ARG226B, ASN12B, ASN191A, ASN191B, ASN30A, ASN30B, ASN60A, ASN74A, ASN74B, ASP221A, ASP221B, ASP224A, ASP224B, ASP29A, ASP29B, ASP33A, ASP33B, ASP55A, ASP65A, ASP65B, ASP73A, ASP73B, ASP7B, ASP90A, CYS152A, CYS152B, CYS67A, GLN195A, GLN195B, GLN69A, GLN69B, GLN6B, GLU161A, GLU161B, GLU192A, GLU21B, GLY150A, GLY150B, GLY15B, GLY217A, GLY217B, GLY225A, GLY225B, GLY61A, GLY71A, GLY71B, GLY89A, HIS16B, HIS37A, HIS37B, ILE5B, ILE68A, ILE68B, LEU153A, LEU164A, LEU164B, LEU187A, LEU187B, LEU34A, LEU34B, LEU45A, LEU45B, LYS11B, LYS149A, LYS18B, LYS207A, LYS207B, LYS24B, LYS26A, LYS26B, LYS36A, LYS36B, LYS56A, LYS66A, LYS66B, LYS78A, LYS78B, MET157A, MET157B, MET190A, MET190B, MET41A, MET41B, PHE25A, PHE25B, PHE31A, PHE31B, PHE64A, PHE64B, PHE9B, PRO154A, PRO155A, PRO186B, PRO19B, PRO223A, PRO223B, PRO32A, PRO32B, PRO59A, PRO75A, PRO75B, SER158A, SER158B, SER17B, SER216A, SER22B, SER35A, SER35B, THR188A, THR188B, THR189A, THR189B, THR214A, THR214B, THR215A, THR215B, THR58A, THR63A, THR70A, THR70B, TRP20B, TRP222A, TRP222B, TRP54A, TRP54B, TYR50A, TYR50B, TYR53A, TYR8B, TYR97A, VAL10B, VAL14B, VAL151A, VAL151B, VAL165A, VAL165B, VAL57A, VAL62A, VAL72A, VAL72B
• A-D: ALA373D, ARG358A, ARG358D, ASN125A, ASN369D, ASP115A, ASP121A, ASP123A, ASP256A, ASP366A, ASP366D, ASP386D, GLN362A, GLN362D, GLN382D, GLU133D, GLU359A, GLY129A, GLY129D, GLY130D, GLY354A, GLY367D, HIS124A, ILE372D, LEU127A, LEU127D, LEU326D, LEU370D, LYS116A, LYS126A, LYS126D, LYS258A, LYS355D, LYS376D, LYS377D, LYS390D, MET387D, PHE132D, PRO118A, PRO389D, SER356A, VAL128A, VAL128D, VAL131A, VAL131D, VAL363A, VAL363D, VAL365D, VAL368D
• A-H: ALA181A, ALA42H, ARG266A, ARG273A, ARG318H, ASN232A, ASN38H, ASN39H, ASP171A, ASP179A, GLN44H, GLU106H, GLU107H, GLU233A, GLU321H, GLY174A, GLY175A, GLY178A, HIS110H, HIS37H, ILE388H, LEU176A, LEU180A, LEU34H, LEU45H, LYS103H, LYS112H, LYS167A, LYS177A, LYS183A, LYS325H, LYS36H, LYS390H, LYS47H, LYS82H, MET41H, PRO389H, SER35H, SER43H, THR46H, TYR185A, VAL40H
• B-H: ALA28B, ASP29B, ASP385H, ASP386H, LYS26B, SER383H
• C-D: ALA156C, ALA160C, ALA160D, ALA219C, ALA219D, ALA27C, ALA27D, ALA28C, ALA28D, ARG13D, ARG159C, ARG159D, ARG162C, ARG162D, ARG163C, ARG163D, ARG220C, ARG220D, ARG226C, ARG226D, ASN12D, ASN191C, ASN191D, ASN30C, ASN30D, ASN60C, ASN60D, ASN74C, ASN74D, ASP221C, ASP221D, ASP224C, ASP224D, ASP29C, ASP29D, ASP33C, ASP33D, ASP55C, ASP65C, ASP65D, ASP73C, ASP73D, ASP90C, CYS152C, CYS152D, CYS67C, GLN195D, GLN69C, GLN69D, GLU161C, GLU161D, GLU21D, GLY150C, GLY150D, GLY15D, GLY217C, GLY217D, GLY225D, GLY61C, GLY71C, GLY71D, GLY89C, HIS16D, HIS37C, HIS37D, ILE68C, ILE68D, LEU153C, LEU164C, LEU164D, LEU187C, LEU187D, LEU34C, LEU34D, LEU45C, LEU45D, LYS11D, LYS149C, LYS18D, LYS207C, LYS207D, LYS24C, LYS24D, LYS26C, LYS26D, LYS36C, LYS36D, LYS56C, LYS66C, LYS66D, LYS78C, LYS78D, MET157C, MET157D, MET190C, MET190D, MET41C, MET41D, PHE25C, PHE25D, PHE31C, PHE31D, PHE64C, PHE64D, PHE9D, PRO154C, PRO155C, PRO186D, PRO19D, PRO223C, PRO223D, PRO32C, PRO32D, PRO59C, PRO75C, PRO75D, SER158C, SER158D, SER17D, SER216C, SER22D, SER35C, THR188C, THR188D, THR189C, THR189D, THR209C, THR214C, THR214D, THR215C, THR215D, THR58C, THR63C, THR70C, THR70D, TRP20D, TRP222C, TRP222D, TRP54C, TRP54D, TYR50C, TYR50D, TYR53C, TYR97C, VAL10D, VAL14D, VAL151C, VAL151D, VAL165C, VAL165D, VAL57C, VAL62C, VAL72C, VAL72D
• C-F: ALA119C, ALA373F, ARG358C, ARG358F, ASN125C, ASN125F, ASN369F, ASP115C, ASP121C, ASP123C, ASP366C, ASP366F, ASP386F, GLN362C, GLN362F, GLU133F, GLU359C, GLY129C, GLY129F, GLY130F, GLY354C, GLY367F, HIS117C, ILE372F, LEU127C, LEU127F, LEU326F, LEU360C, LEU370F, LYS116C, LYS126C, LYS126F, LYS258C, LYS355C, LYS376F, LYS377F, LYS390F, MET387F, PHE111C, PHE132F, PRO118C, PRO389F, SER114C, SER356C, VAL128C, VAL128F, VAL131C, VAL363C, VAL363F, VAL365F
• C-J: ALA181C, ALA42J, ARG266C, ARG318J, ASN232C, ASN38J, ASN39J, ASP171C, ASP179C, GLN44J, GLU106J, GLU107J, GLU233C, GLU321J, GLU48J, GLY178C, HIS37J, ILE388J, LEU176C, LEU180C, LEU45J, LYS103J, LYS112J, LYS167C, LYS177C, LYS183C, LYS325J, LYS390J, LYS47J, LYS82J, LYS83J, MET41J, PRO389J, SER43J, THR46J, TYR185C, VAL40J
• D-G: ALA181G, ALA259G, ALA42D, ARG263G, ARG266G, ARG273G, ARG318D, ASN231G, ASN232G, ASN235G, ASN38D, ASN39D, ASP171G, ASP179G, ASP33D, GLN44D, GLU107D, GLU233G, GLU270G, GLU321D, GLU48D, GLY174G, GLY175G, GLY178G, GLY182G, GLY76D, HIS110D, HIS316D, HIS37D, ILE388D, LEU176G, LEU180G, LEU34D, LEU45D, LEU49D, LYS103D, LYS112D, LYS167G, LYS177G, LYS183G, LYS325D, LYS36D, LYS390D, LYS47D, LYS82D, MET322D, MET41D, PHE31D, PRO186G, PRO317D, PRO75D, SER262G, SER35D, SER43D, THR189G, THR46D, TYR185G, VAL40D
• D-H: ALA28H, ASP29H, ASP385D, ASP386D, LYS26H, LYS390D, LYS47H, SER383D
• D-J: ASP385J, LYS26D
• E-F: ALA156E, ALA160E, ALA160F, ALA219E, ALA219F, ALA27E, ALA27F, ALA28E, ALA28F, ARG13F, ARG159E, ARG159F, ARG162E, ARG162F, ARG163E, ARG163F, ARG220E, ARG220F, ARG226E, ARG226F, ASN12F, ASN191E, ASN191F, ASN30E, ASN30F, ASN60E, ASN60F, ASN74E, ASN74F, ASP221E, ASP221F, ASP224E, ASP224F, ASP29E, ASP29F, ASP33E, ASP33F, ASP55E, ASP65E, ASP65F, ASP73E, ASP73F, ASP90E, CYS152E, CYS152F, CYS218E, CYS67E, GLN195E, GLN195F, GLN69E, GLN69F, GLN6F, GLU161E, GLU161F, GLU192E, GLU192F, GLU21F, GLY150E, GLY150F, GLY15F, GLY217E, GLY217F, GLY225E, GLY225F, GLY61E, GLY71F, GLY89E, HIS16F, HIS37E, HIS37F, ILE68E, ILE68F, LEU153E, LEU164E, LEU164F, LEU187E, LEU187F, LEU34E, LEU34F, LEU45E, LEU45F, LYS11F, LYS149E, LYS149F, LYS18F, LYS207E, LYS207F, LYS24E, LYS24F, LYS26E, LYS26F, LYS36E, LYS36F, LYS47E, LYS56E, LYS66E, LYS66F, LYS78E, LYS78F, MET157E, MET157F, MET190E, MET190F, MET41E, MET41F, PHE25E, PHE25F, PHE31E, PHE31F, PHE64E, PHE64F, PHE9F, PRO155E, PRO186F, PRO19F, PRO208F, PRO223E, PRO223F, PRO32E, PRO32F, PRO59E, PRO75E, PRO75F, SER158E, SER158F, SER17F, SER216E, SER22F, SER35E, SER35F, THR188E, THR188F, THR189E, THR189F, THR214E, THR214F, THR215E, THR215F, THR58E, THR63E, THR70E, THR70F, TRP20F, TRP222E, TRP222F, TRP54E, TRP54F, TYR50E, TYR50F, TYR53E, TYR8F, TYR97E, VAL10F, VAL14F, VAL151E, VAL151F, VAL165E, VAL165F, VAL57E, VAL62E, VAL72E, VAL72F
• E-L: ALA181E, ALA42L, ARG266E, ARG273E, ARG318L, ASN231E, ASN232E, ASN38L, ASN39L, ASP171E, ASP179E, GLN44L, GLU106L, GLU107L, GLU233E, GLU270E, GLU277E, GLU321L, GLU48L, GLY174E, GLY175E, GLY178E, GLY182E, HIS110L, HIS37L, ILE388L, LEU176E, LEU180E, LEU34L, LEU45L, LEU49L, LYS103L, LYS112L, LYS167E, LYS177E, LYS183E, LYS325L, LYS36L, LYS390L, LYS47L, LYS82L, MET41L, PHE100L, PHE31L, PRO389L, SER35L, SER43L, THR46L, TYR185E, VAL40L
• F-I: ALA181I, ALA42F, ARG266I, ARG273I, ARG318F, ASN231I, ASN232I, ASN38F, ASN39F, ASP171I, ASP179I, GLN44F, GLU106F, GLU107F, GLU233I, GLU270I, GLU277I, GLU321F, GLU48F, GLU99F, GLY174I, GLY175I, GLY178I, GLY182I, HIS110F, HIS37F, LEU176I, LEU180I, LEU34F, LEU45F, LEU49F, LYS103F, LYS112F, LYS167I, LYS177I, LYS183I, LYS325F, LYS36F, LYS390F, LYS47F, LYS82F, MET41F, PHE31F, SER35F, SER43F, THR46F, TYR185I, VAL40F
• F-J: ALA28J, ARG318F, ASP29J, ASP385F, ASP386F, LYS26J, LYS390F, LYS47J, SER383F
• F-L: ALA28F, ARG318L, ASP29F, ASP385L, ASP386L, ILE384L, LYS26F, LYS390L, SER383L
• G-H: ALA156G, ALA160G, ALA160H, ALA219G, ALA219H, ALA27G, ALA27H, ALA28G, ALA28H, ARG13H, ARG159G, ARG159H, ARG162G, ARG162H, ARG163G, ARG163H, ARG220G, ARG220H, ARG226G, ARG226H, ASN12H, ASN191G, ASN30G, ASN30H, ASN60G, ASN60H, ASN74G, ASN74H, ASP221G, ASP221H, ASP224G, ASP224H, ASP29G, ASP29H, ASP33G, ASP33H, ASP55G, ASP65G, ASP65H, ASP73G, ASP73H, ASP90G, CYS152G, CYS152H, CYS67G, GLN195H, GLN69G, GLN69H, GLU161G, GLU161H, GLU192G, GLU21H, GLY150G, GLY150H, GLY15H, GLY217G, GLY217H, GLY225H, GLY61G, GLY71G, GLY71H, GLY89G, HIS16H, HIS37G, HIS37H, ILE68G, ILE68H, LEU153G, LEU164G, LEU164H, LEU187G, LEU187H, LEU34G, LEU34H, LEU45G, LEU45H, LYS11H, LYS149G, LYS149H, LYS18H, LYS207G, LYS24G, LYS24H, LYS26G, LYS26H, LYS36G, LYS36H, LYS47H, LYS56G, LYS66G, LYS66H, LYS78H, MET157G, MET157H, MET190G, MET190H, MET41G, MET41H, PHE25G, PHE25H, PHE31G, PHE31H, PHE64G, PHE64H, PHE9H, PRO154G, PRO155G, PRO19H, PRO223G, PRO223H, PRO32G, PRO32H, PRO59G, PRO75G, PRO75H, SER158G, SER158H, SER17H, SER216G, SER22H, SER35G, THR188G, THR188H, THR189G, THR189H, THR214G, THR214H, THR215G, THR215H, THR58G, THR63G, THR70G, THR70H, TRP20H, TRP222G, TRP222H, TRP54G, TRP54H, TYR50G, TYR50H, TYR53G, TYR8H, TYR97G, VAL10H, VAL148G, VAL14H, VAL151G, VAL151H, VAL165G, VAL165H, VAL168G, VAL57G, VAL62G, VAL72G, VAL72H
• G-J: ALA373J, ARG327J, ARG358G, ARG358J, ASN125G, ASN369G, ASN369J, ASP115G, ASP123G, ASP366G, ASP366J, ASP386J, CYS374J, GLN362G, GLN362J, GLN382J, GLU359G, GLY129G, GLY129J, GLY367J, HIS124G, ILE372J, ILE388J, LEU127G, LEU326J, LEU370J, LEU371J, LYS112G, LYS116G, LYS126G, LYS126J, LYS258G, LYS325J, LYS355G, LYS376J, LYS377J, LYS390J, MET387J, PHE111G, PRO118G, PRO389J, SER356G, VAL128G, VAL128J, VAL131G, VAL363G, VAL363J, VAL365J, VAL368J
• G-M: ALA181M, ALA259M, ALA42G, ARG263M, ARG266M, ARG318G, ARG327G, ASN125M, ASN191M, ASN231M, ASN232M, ASN235M, ASN38G, ASN39G, ASP134M, ASP179M, ASP194M, ASP256M, ASP320G, ASP33G, ASP385G, ASP386G, CYS140M, GLN252M, GLN44G, GLU106G, GLU107G, GLU133M, GLU233M, GLU321G, GLY178M, GLY182M, GLY254M, GLY255M, GLY324G, GLY81G, HIS110G, HIS124M, HIS230M, HIS316G, HIS37G, ILE384G, ILE388G, LEU257M, LEU323G, LEU34G, LYS103G, LYS138M, LYS167M, LYS177M, LYS183M, LYS234M, LYS253M, LYS258M, LYS315G, LYS325G, LYS36G, LYS390G, LYS47G, LYS82G, MET190M, MET322G, PHE132M, PHE319G, PRO186M, PRO317G, PRO75G, SER139M, SER262M, SER35G, SER383G, SER43G, THR188M, THR189M, TRP350G, TYR184M, TYR185M, VAL131M, VAL137M, VAL260M, VAL40G
• G-P: ASP386G, ASP386P, GLN382G, GLN382P, LYS377G, LYS377P, LYS390G, LYS390P, MET387P
• H-M: ASN191H, ASN191M, ASP194H, ASP194M, GLN195H, GLN197H, GLU192H, GLU192M, GLU196H, GLU196M, LYS193H, LYS193M, LYS207H, LYS207M, MET190H, MET190M, THR188H, THR188M, THR189H, THR189M
• H-N: ALA259H, ARG263H, ARG266H, ARG318N, ASN191H, ASN231H, ASN232H, ASN235H, ASN38N, ASN39N, ASP179H, ASP256H, ASP320N, ASP385N, GLN252H, GLU233H, GLU321N, GLY178H, GLY254H, GLY324N, HIS230H, HIS37N, ILE388N, LEU34N, LYS183H, LYS253H, LYS315N, LYS325N, LYS36N, LYS82N, MET190H, MET322N, PHE319N, PRO186H, PRO317N, PRO75N, SER35N, THR188H, THR189H, TYR184H, TYR185H
• I-J: ALA156I, ALA160I, ALA160J, ALA219I, ALA219J, ALA27I, ALA27J, ALA28I, ALA28J, ARG13J, ARG159I, ARG159J, ARG162I, ARG162J, ARG163I, ARG163J, ARG220I, ARG220J, ARG226I, ARG226J, ASN12J, ASN191I, ASN191J, ASN30I, ASN30J, ASN60I, ASN74I, ASN74J, ASP221I, ASP221J, ASP224I, ASP224J, ASP29I, ASP29J, ASP33I, ASP33J, ASP55I, ASP65I, ASP65J, ASP73I, ASP73J, ASP7J, ASP90I, CYS152I, CYS152J, CYS67I, GLN195I, GLN195J, GLN69I, GLN69J, GLN6J, GLU161I, GLU161J, GLU192I, GLU192J, GLU21J, GLY150I, GLY150J, GLY15J, GLY217I, GLY217J, GLY225J, GLY61I, GLY71I, GLY89I, HIS16J, HIS37I, HIS37J, ILE68I, ILE68J, LEU153I, LEU164I, LEU164J, LEU187I, LEU187J, LEU34I, LEU34J, LEU45I, LEU45J, LYS11J, LYS149I, LYS18J, LYS207I, LYS207J, LYS24J, LYS26I, LYS26J, LYS36I, LYS36J, LYS56I, LYS66I, LYS66J, LYS78I, LYS78J, MET157I, MET157J, MET190I, MET190J, MET41I, MET41J, PHE25I, PHE25J, PHE31I, PHE31J, PHE64I, PHE64J, PHE9J, PRO154I, PRO155I, PRO186J, PRO19J, PRO223I, PRO223J, PRO32I, PRO32J, PRO59I, PRO75I, PRO75J, SER158I, SER158J, SER17J, SER216I, SER22J, SER35I, SER35J, THR188I, THR188J, THR189I, THR189J, THR209J, THR214I, THR214J, THR215I, THR215J, THR58I, THR63I, THR70I, THR70J, TRP20J, TRP222I, TRP222J, TRP54I, TRP54J, TYR50I, TYR50J, TYR53I, TYR8J, TYR97I, VAL10J, VAL14J, VAL151I, VAL151J, VAL165I, VAL165J, VAL57I, VAL62I, VAL72I, VAL72J
• I-L: ALA373L, ARG358I, ARG358L, ASN125I, ASN125L, ASN369L, ASP115I, ASP121I, ASP123I, ASP366I, ASP366L, ASP386L, GLN362I, GLN362L, GLU133L, GLU359I, GLY129I, GLY129L, GLY130L, GLY354I, GLY367L, HIS124I, ILE372L, LEU127I, LEU127L, LEU326L, LEU360I, LEU370L, LYS116I, LYS126I, LYS126L, LYS258I, LYS355I, LYS376L, LYS377L, LYS390L, MET387L, PHE132L, PRO118I, PRO389L, SER356I, VAL128I, VAL128L, VAL131I, VAL131L, VAL363I, VAL363L, VAL365L, VAL368L
• I-O: ALA181O, ALA259O, ALA42I, ARG263O, ARG318I, ASN191O, ASN231O, ASN232O, ASN235O, ASN38I, ASN39I, ASN77I, ASP134O, ASP171O, ASP179O, ASP194O, ASP256O, ASP320I, ASP33I, ASP385I, ASP386I, GLN252O, GLN382I, GLN44I, GLU106I, GLU107I, GLU133O, GLU233O, GLU321I, GLY174O, GLY178O, GLY182O, GLY254O, GLY255O, GLY324I, GLY76I, HIS110I, HIS230O, HIS316I, HIS37I, ILE108I, ILE384I, ILE388I, LEU187O, LEU198O, LEU34I, LEU378I, LEU45I, LYS103I, LYS112I, LYS135O, LYS138O, LYS167O, LYS177O, LYS183O, LYS193O, LYS234O, LYS253O, LYS325I, LYS36I, LYS390I, LYS47I, LYS78I, LYS82I, MET190O, MET322I, MET41I, PHE132O, PHE319I, PRO186O, PRO317I, PRO389I, PRO75I, SER139O, SER170O, SER35I, SER383I, SER43I, THR188O, THR189O, THR46I, TRP350I, TYR184O, TYR185O, VAL131O, VAL137O, VAL260O, VAL40I
• I-P: LYS36I, LYS36P
• I-R: ASP386I, ASP386R
• J-O: ASN191J, ASN191O, ASP194J, ASP194O, GLN195J, GLN195O, GLU192J, GLU192O, GLU196J, GLU196O, LEU187J, LEU187O, LYS193J, LYS193O, LYS207J, LYS207O, MET190J, MET190O, PRO223J, PRO223O, THR188J, THR188O, THR189J, THR189O
• J-P: ALA181J, ALA259J, ALA42P, ARG263J, ARG318P, ARG327P, ASN191J, ASN231J, ASN232J, ASN235J, ASN38P, ASN39P, ASN77P, ASP134J, ASP171J, ASP179J, ASP194J, ASP256J, ASP320P, ASP33P, ASP385P, ASP386P, CYS140J, GLN252J, GLN382P, GLN44P, GLU106P, GLU107P, GLU133J, GLU166J, GLU192J, GLU233J, GLU321P, GLY174J, GLY178J, GLY182J, GLY254J, GLY255J, GLY324P, GLY76P, HIS110P, HIS230J, HIS316P, HIS37P, ILE108P, ILE384P, ILE388P, LEU187J, LEU198J, LEU34P, LEU378P, LEU45P, LYS103P, LYS112P, LYS135J, LYS138J, LYS167J, LYS177J, LYS183J, LYS193J, LYS234J, LYS253J, LYS325P, LYS36P, LYS390P, LYS47P, LYS78P, LYS82P, MET190J, MET41P, PHE132J, PHE319P, PRO186J, PRO317P, PRO389P, PRO75P, SER139J, SER35P, SER383P, SER43P, THR188J, THR189J, THR46P, TYR184J, TYR185J, VAL131J, VAL137J, VAL40P
• K-L: ALA156K, ALA160K, ALA160L, ALA219K, ALA219L, ALA27K, ALA27L, ALA28K, ALA28L, ARG13L, ARG159K, ARG159L, ARG162K, ARG162L, ARG163K, ARG163L, ARG220K, ARG220L, ARG226K, ARG226L, ASN12L, ASN191K, ASN191L, ASN30K, ASN30L, ASN60K, ASN60L, ASN74K, ASN74L, ASP221K, ASP221L, ASP224K, ASP224L, ASP29K, ASP29L, ASP33K, ASP33L, ASP55K, ASP65K, ASP65L, ASP73K, ASP73L, ASP7L, ASP90K, CYS152K, CYS152L, CYS218K, CYS67K, GLN195K, GLN195L, GLN69K, GLN69L, GLU161K, GLU161L, GLU192K, GLU192L, GLU21L, GLY150K, GLY150L, GLY15L, GLY217K, GLY217L, GLY225K, GLY61K, GLY71K, GLY89K, HIS16L, HIS37K, HIS37L, ILE68K, ILE68L, LEU153K, LEU164K, LEU164L, LEU187K, LEU187L, LEU34K, LEU34L, LEU45K, LEU45L, LYS11L, LYS149K, LYS18L, LYS207K, LYS207L, LYS24K, LYS24L, LYS26K, LYS26L, LYS36K, LYS36L, LYS56K, LYS66K, LYS66L, LYS78K, LYS78L, MET157K, MET157L, MET190K, MET190L, MET41K, MET41L, PHE25K, PHE25L, PHE31K, PHE31L, PHE64K, PHE64L, PHE9L, PRO154K, PRO155K, PRO186L, PRO19L, PRO223K, PRO223L, PRO32K, PRO32L, PRO59K, PRO75K, PRO75L, SER158K, SER158L, SER17L, SER216K, SER22L, SER35K, SER35L, THR188K, THR188L, THR189K, THR189L, THR209K, THR214K, THR214L, THR215K, THR215L, THR58K, THR63K, THR70K, THR70L, TRP20L, TRP222K, TRP222L, TRP54K, TRP54L, TYR50K, TYR50L, TYR53K, TYR8L, TYR92L, TYR97K, VAL10L, VAL14L, VAL151K, VAL151L, VAL165K, VAL165L, VAL57K, VAL62K, VAL72K, VAL72L
• K-Q: ALA181Q, ALA259Q, ALA42K, ARG263Q, ARG318K, ASN191Q, ASN231Q, ASN232Q, ASN235Q, ASN38K, ASN39K, ASN77K, ASP134Q, ASP179Q, ASP194Q, ASP256Q, ASP320K, ASP33K, ASP385K, ASP386K, GLN252Q, GLN382K, GLN44K, GLU106K, GLU107K, GLU133Q, GLU233Q, GLU321K, GLY178Q, GLY182Q, GLY254Q, GLY255Q, GLY324K, GLY76K, HIS110K, HIS230Q, HIS316K, HIS37K, ILE108K, ILE384K, ILE388K, LEU187Q, LEU198Q, LEU34K, LEU378K, LEU45K, LYS103K, LYS112K, LYS135Q, LYS138Q, LYS167Q, LYS177Q, LYS183Q, LYS234Q, LYS253Q, LYS325K, LYS36K, LYS390K, LYS47K, LYS82K, MET190Q, MET322K, MET41K, PHE132Q, PHE319K, PRO186Q, PRO317K, PRO389K, PRO75K, SER139Q, SER35K, SER383K, SER43K, THR188Q, THR189Q, TYR184Q, TYR185Q, VAL131Q, VAL137Q, VAL260Q, VAL40K
• L-Q: ASN191L, ASN191Q, ASP194L, ASP194Q, GLN195L, GLN195Q, GLU192L, GLU192Q, GLU196L, GLU196Q, LEU187L, LEU187Q, LYS193L, LYS193Q, LYS207L, LYS207Q, MET190L, MET190Q, PRO223L, PRO223Q, THR188L, THR188Q, THR189L, THR189Q
• L-R: ARG318R, ASN232L, ASP134L, ASP194L, ASP256L, ASP320R, ASP385R, ASP386R, GLU233L, GLU321R, HIS316R, HIS37R, LEU34R, LYS183L, LYS253L, LYS325R, LYS36R, LYS390R, LYS82R
• M-N: ALA156M, ALA160M, ALA160N, ALA219M, ALA219N, ALA27M, ALA27N, ALA28M, ALA28N, ARG13N, ARG159M, ARG159N, ARG162M, ARG162N, ARG163M, ARG163N, ARG220M, ARG220N, ARG226M, ARG226N, ASN12N, ASN191M, ASN191N, ASN30M, ASN30N, ASN60M, ASN60N, ASN74M, ASN74N, ASP221M, ASP221N, ASP224M, ASP224N, ASP29M, ASP29N, ASP33M, ASP33N, ASP55M, ASP65M, ASP65N, ASP73M, ASP73N, ASP90M, CYS152M, CYS152N, CYS218M, CYS67M, GLN195M, GLN195N, GLN69M, GLN69N, GLU161M, GLU161N, GLU192M, GLU192N, GLU21N, GLY150M, GLY150N, GLY15N, GLY217M, GLY217N, GLY225M, GLY225N, GLY61M, GLY71M, GLY71N, GLY89M, HIS16N, HIS37M, HIS37N, ILE68M, ILE68N, LEU153M, LEU164M, LEU164N, LEU187M, LEU187N, LEU34M, LEU34N, LEU45M, LEU45N, LYS11N, LYS149M, LYS18N, LYS207M, LYS207N, LYS24M, LYS24N, LYS26M, LYS26N, LYS36M, LYS36N, LYS56M, LYS66M, LYS66N, LYS78M, LYS78N, MET157M, MET157N, MET190M, MET190N, MET41M, MET41N, PHE25M, PHE25N, PHE31M, PHE31N, PHE64M, PHE64N, PHE9N, PRO154M, PRO155M, PRO19N, PRO223M, PRO223N, PRO32M, PRO32N, PRO59M, PRO75M, PRO75N, SER158M, SER158N, SER17N, SER216M, SER22N, SER35M, SER35N, THR188M, THR188N, THR189M, THR189N, THR214M, THR214N, THR215M, THR215N, THR58M, THR63M, THR70M, THR70N, TRP20N, TRP222M, TRP222N, TRP54M, TRP54N, TYR50M, TYR50N, TYR53M, TYR92N, VAL10N, VAL148M, VAL14N, VAL151M, VAL151N, VAL165M, VAL165N, VAL57M, VAL62M, VAL72M, VAL72N
• M-P: ALA119M, ALA119P, ALA373P, ARG358M, ARG358P, ASN125M, ASN125P, ASN369P, ASP115M, ASP121M, ASP121P, ASP123M, ASP123P, ASP366M, ASP366P, GLN362M, GLN362P, GLU357M, GLU359M, GLU359P, GLY129M, GLY129P, GLY130P, GLY354M, GLY367P, HIS109M, HIS110M, HIS117M, LEU127M, LEU127P, LEU326P, LEU353M, LEU360M, LEU370P, LYS112M, LYS116M, LYS126M, LYS126P, LYS258M, LYS258P, LYS355M, LYS355P, LYS390P, PHE111M, PHE132P, PRO118M, PRO120M, PRO389P, SER356M, VAL128M, VAL128P, VAL361M, VAL363M, VAL363P, VAL365P
• O-P: ALA156O, ALA160O, ALA160P, ALA219O, ALA219P, ALA27O, ALA27P, ALA28O, ALA28P, ARG13P, ARG159O, ARG159P, ARG162O, ARG162P, ARG163O, ARG163P, ARG220O, ARG220P, ARG226O, ARG226P, ASN12P, ASN191O, ASN191P, ASN30O, ASN30P, ASN60O, ASN74O, ASN74P, ASP221O, ASP221P, ASP224O, ASP224P, ASP29O, ASP29P, ASP33O, ASP33P, ASP55O, ASP65O, ASP65P, ASP73O, ASP73P, ASP90O, CYS152O, CYS152P, CYS218O, CYS67O, GLN195O, GLN195P, GLN69O, GLN69P, GLU161O, GLU161P, GLU192O, GLU192P, GLU21P, GLY150O, GLY150P, GLY15P, GLY217O, GLY217P, GLY225O, GLY225P, GLY61O, GLY71O, GLY71P, GLY89O, HIS16P, HIS37O, HIS37P, ILE68O, ILE68P, LEU153O, LEU164O, LEU164P, LEU187O, LEU187P, LEU34O, LEU34P, LEU45O, LEU45P, LYS11P, LYS149O, LYS18P, LYS207O, LYS207P, LYS24P, LYS26O, LYS26P, LYS36O, LYS36P, LYS66O, LYS66P, LYS78O, LYS78P, MET157O, MET157P, MET190O, MET190P, MET41O, MET41P, PHE25O, PHE25P, PHE31O, PHE31P, PHE64O, PHE64P, PRO154O, PRO155O, PRO19P, PRO223O, PRO223P, PRO32O, PRO32P, PRO59O, PRO75O, PRO75P, SER158O, SER158P, SER17P, SER216O, SER22P, SER35O, SER35P, THR188O, THR188P, THR189O, THR189P, THR209O, THR214O, THR214P, THR215O, THR215P, THR58O, THR63O, THR70O, THR70P, TRP20P, TRP222O, TRP222P, TRP54O, TRP54P, TYR50O, TYR50P, TYR97O, VAL10P, VAL14P, VAL151O, VAL151P, VAL165O, VAL165P, VAL57O, VAL62O, VAL72O, VAL72P
• O-R: ASP123R, ASP366O, GLU359R, LYS126O, LYS126R
• Q-R: ALA160Q, ALA160R, ARG13R, ARG159Q, ARG159R, ARG163Q, ARG163R, ARG220Q, ARG220R, ASN30Q, ASN30R, ASP221Q, ASP221R, ASP224Q, ASP224R, ASP29Q, ASP29R, ASP33Q, ASP33R, ASP65Q, ASP65R, ASP73Q, ASP73R, GLN69Q, GLU161Q, HIS16R, LYS24R, LYS66Q, TYR50R