3L28

crystal structure of zaire ebola vp35 interferon inhibitory domain k339a mutant

• Total interactions analyzed: 15
• Total true interactions: 9
• Strongest Interaction:
  • Chains: A-B
  • Int. Res.: 108
  • Norm. En. per Res.: -3.5956
• Hub Node: A(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-52.8081	-61.2777	-274.239	-388.3248	108	9	1	10446	5	25	25
A-C	0.0	16.291	-3.3223	12.9687	19	0	0	551	0	2	15
A-D	-25.3041	-4.561	-104.265	-134.1301	41	6	0	3774	3	12	12
A-E	0.0	-12.846	-8.4948	-21.3408	8	0	0	332	1	2	0
B-C	-22.4487	-4.1629	-96.7445	-123.3562	38	2	0	3202	1	12	12
B-E	-33.2531	5.4014	-153.369	-181.2207	74	6	3	6795	0	15	12
B-F	0.0	0.0	-0.3478	-0.3478	6	0	0	61	0	1	0
C-D	-40.6191	-63.075	-267.48	-371.1741	107	6	1	10574	5	24	25
E-F	-40.3561	-36.8536	-252.294	-329.5037	101	11	1	10269	2	23	25

Interface residues

• A-B: ALA238A, ALA238B, ALA265A, ALA265B, ALA268A, ALA268B, ALA276A, ALA276B, ALA306A, ALA306B, ALA339A, ALA339B, ARG283A, ARG283B, ARG300B, ARG305A, ARG305B, ARG312A, ARG312B, ARG322A, ARG322B, ASP230A, ASP230B, ASP271A, ASP271B, ASP321A, ASP321B, CYS275A, CYS275B, GLN274A, GLN274B, GLN279A, GLN279B, GLN308A, GLN308B, GLU269A, GLU269B, GLY234A, GLY234B, GLY236B, GLY270A, GLY270B, GLY323A, GLY323B, GLY337A, GLY337B, HIS231A, HIS231B, ILE227A, ILE278A, ILE278B, ILE280A, ILE280B, ILE320A, ILE320B, ILE340A, ILE340B, LEU232A, LEU232B, LEU267A, LEU267B, LEU277A, LEU277B, LEU311A, LEU311B, LEU338A, LEU338B, LYS282A, LYS282B, LYS309A, LYS309B, LYS319A, LYS319B, PHE235A, PHE235B, PHE239A, PHE239B, PHE263A, PHE263B, PRO233A, PRO233B, PRO273A, PRO273B, PRO313A, PRO313B, PRO315A, PRO315B, PRO316A, PRO316B, PRO318A, PRO318B, SER266A, SER266B, SER272A, SER272B, SER310A, SER310B, SER317A, SER317B, THR237A, THR237B, THR281B, TRP324A, TRP324B, TYR229A, VAL314B, VAL325A, VAL325B
• A-C: ARG300A, ARG300C, ARG305A, ARG305C, ARG312A, ARG312C, GLN308A, GLN308C, GLY301A, GLY301C, LEU311A, LEU311C, LYS309A, LYS309C, LYS334A, LYS334C, PRO313A, PRO313C, SER310C
• A-D: ALA306D, ARG225D, ARG298A, ARG300A, ARG305A, ARG305D, ASN226D, ASP230D, ASP302A, ASP302D, ASP332A, CYS307D, GLN241D, GLN244D, GLN308A, GLN308D, GLN331A, GLY234D, GLY236D, GLY301A, GLY301D, GLY333A, HIS231D, HIS240D, ILE227D, ILE297A, ILE303A, ILE303D, LEU232D, LEU311A, LEU330A, LEU336A, LYS334A, PHE235D, PRO233D, PRO304D, SER299A, THR237D, THR335A, TYR229D, VAL243D
• A-E: ALA268A, GLN329E, GLU269A, GLY270A, HIS296E, ILE295E, LEU267A, VAL294E
• B-C: ALA306B, ARG225B, ARG298C, ARG300C, ARG305B, ARG305C, ASN226B, ASP230B, ASP302B, ASP302C, ASP332C, GLN308C, GLN329C, GLN331C, GLY234B, GLY236B, GLY301C, GLY333C, HIS231B, HIS240B, ILE297C, ILE303B, ILE303C, LEU232B, LEU311C, LEU330C, LEU336C, LYS222B, LYS334C, PHE235B, PRO233B, PRO304B, PRO313C, SER299C, THR237B, THR335C, TYR229B, VAL243B
• B-E: ALA290B, ALA290E, ALA291B, ALA291E, ARG322B, ARG322E, ASN254B, ASP252B, ASP252E, ASP289B, ASP289E, CYS326B, CYS326E, GLN288B, GLN288E, GLN329B, GLN329E, GLY250E, GLY333B, GLY333E, GLY337E, HIS296B, HIS296E, ILE286B, ILE286E, ILE295E, ILE320B, ILE320E, LEU249B, LEU249E, LEU256E, LEU330B, LEU330E, LEU336B, LEU336E, LYS248B, LYS248E, LYS251E, LYS319B, LYS319E, LYS334B, LYS334E, PHE287B, PHE287E, PHE328B, PHE328E, PRO285B, PRO285E, PRO292B, PRO292E, PRO293B, PRO293E, PRO315B, PRO315E, PRO316B, PRO316E, PRO318B, PRO318E, SER253B, SER255B, SER317B, SER317E, THR335B, THR335E, TRP324E, VAL245B, VAL245E, VAL284B, VAL294B, VAL294E, VAL314B, VAL314E, VAL327B, VAL327E
• B-F: ALA268F, GLN329B, GLU269F, GLY270F, HIS296B, VAL294B
• C-D: ALA238C, ALA238D, ALA265C, ALA265D, ALA268C, ALA268D, ALA276C, ALA276D, ALA306C, ALA306D, ALA339C, ALA339D, ARG283C, ARG283D, ARG305C, ARG305D, ARG312C, ARG312D, ARG322C, ARG322D, ASP230C, ASP230D, ASP271C, ASP271D, ASP321C, ASP321D, CYS275C, CYS275D, CYS307D, GLN274C, GLN274D, GLN279C, GLN279D, GLN308C, GLN308D, GLU269C, GLU269D, GLY234C, GLY234D, GLY236D, GLY270C, GLY270D, GLY323C, GLY323D, GLY337C, GLY337D, HIS231C, HIS231D, ILE278C, ILE278D, ILE280C, ILE280D, ILE320C, ILE320D, ILE340C, ILE340D, LEU232C, LEU232D, LEU267C, LEU267D, LEU277C, LEU277D, LEU311C, LEU311D, LEU338C, LEU338D, LYS282C, LYS282D, LYS309C, LYS309D, LYS319C, LYS319D, PHE235C, PHE235D, PHE239C, PHE239D, PHE263C, PHE263D, PRO233C, PRO233D, PRO273C, PRO273D, PRO313C, PRO313D, PRO315C, PRO315D, PRO316C, PRO316D, PRO318C, PRO318D, SER266C, SER266D, SER272C, SER272D, SER310C, SER310D, SER317C, SER317D, THR237C, THR237D, THR281C, THR281D, TRP324C, TRP324D, TYR229C, VAL325C, VAL325D
• E-F: ALA238E, ALA238F, ALA265E, ALA268E, ALA268F, ALA276E, ALA276F, ALA306E, ALA339E, ALA339F, ARG283E, ARG283F, ARG300F, ARG305F, ARG312E, ARG312F, ARG322E, ARG322F, ASP230E, ASP230F, ASP271E, ASP271F, ASP321E, ASP321F, CYS275E, CYS275F, GLN264E, GLN274E, GLN274F, GLN279E, GLN279F, GLN308E, GLU269E, GLU269F, GLY234E, GLY234F, GLY270E, GLY270F, GLY323E, GLY323F, GLY337E, GLY337F, HIS231E, HIS231F, ILE278E, ILE278F, ILE280E, ILE320E, ILE320F, ILE340E, ILE340F, LEU232E, LEU232F, LEU267E, LEU267F, LEU277E, LEU277F, LEU311E, LEU311F, LEU338E, LEU338F, LYS282E, LYS282F, LYS309E, LYS319E, LYS319F, PHE235F, PHE239E, PHE239F, PHE263E, PHE263F, PRO233E, PRO233F, PRO273E, PRO273F, PRO313E, PRO313F, PRO315E, PRO315F, PRO316E, PRO316F, PRO318E, PRO318F, SER266E, SER266F, SER272E, SER272F, SER310E, SER310F, SER317E, SER317F, THR237E, THR237F, THR281E, THR281F, TRP324E, TRP324F, TYR229F, VAL314F, VAL325E, VAL325F