3L27

crystal structure of zaire ebola vp35 interferon inhibitory domain r312a mutant

• Total interactions analyzed: 6
• Total true interactions: 5
• Strongest Interaction:
  • Chains: B-D
  • Int. Res.: 63
  • Norm. En. per Res.: -3.2943
• Hub Node: A(2)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-33.3891	-44.8194	-126.868	-205.0765	64	6	7	5344	4	21	13
A-C	0.0	0.0	-0.0038	-0.0038	4	0	0	2	0	1	0
B-C	-34.8919	7.1689	-169.585	-197.308	78	4	3	6972	0	14	10
B-D	-21.4246	-52.5939	-133.524	-207.5425	63	4	7	5298	4	21	13
C-D	0.0	0.0	-0.8039	-0.8039	8	0	0	88	0	1	1

Interface residues

• A-B: ALA238B, ALA261A, ALA265A, ALA268A, ALA276B, ALA306B, ALA312B, ARG283A, ARG300B, ARG322B, ASN254A, ASP218A, ASP257A, ASP271A, ASP271B, ASP321B, CYS275B, CYS307B, GLN264A, GLN274B, GLN279B, GLN288A, GLN308B, GLU262A, GLU269A, GLY270A, GLY323B, GLY337B, HIS260A, ILE219A, ILE227A, ILE258A, ILE259A, ILE278B, ILE320B, ILE340B, LEU232B, LEU256A, LEU267A, LEU277B, LEU311B, LEU336B, LEU338B, LYS282B, LYS309B, LYS339B, PHE239B, PHE263A, PRO217A, PRO233B, PRO273B, PRO285A, PRO313B, PRO315B, PRO316B, SER255A, SER266A, SER272B, SER310B, THR237B, TRP324B, VAL284A, VAL314B, VAL325B
• A-C: GLN288A, GLN329C, HIS296C, PRO285A
• B-C: ALA290B, ALA290C, ALA291B, ALA291C, ARG322B, ASN254B, ASN254C, ASP252B, ASP252C, ASP289B, ASP289C, ASP321B, CYS326B, CYS326C, GLN288B, GLN288C, GLN329B, GLN329C, GLY250B, GLY250C, GLY333B, GLY333C, GLY337B, GLY337C, HIS296B, HIS296C, ILE286B, ILE286C, ILE295B, ILE295C, ILE320B, ILE320C, LEU249B, LEU249C, LEU330C, LEU336B, LEU336C, LYS248B, LYS248C, LYS251B, LYS251C, LYS319B, LYS319C, LYS334B, LYS334C, PHE287B, PHE287C, PHE328B, PHE328C, PRO285B, PRO285C, PRO292B, PRO292C, PRO293B, PRO293C, PRO315B, PRO315C, PRO316B, PRO316C, PRO318B, PRO318C, SER253B, SER253C, SER255B, SER317B, SER317C, THR335B, THR335C, TRP324C, VAL245B, VAL245C, VAL284B, VAL294B, VAL294C, VAL314B, VAL314C, VAL327B, VAL327C
• B-D: ALA238D, ALA261B, ALA265B, ALA268B, ALA276D, ALA306D, ALA312D, ARG283B, ARG300D, ARG322D, ASN254B, ASP218B, ASP257B, ASP271B, ASP271D, ASP321D, CYS275D, CYS307D, GLN264B, GLN274D, GLN279B, GLN288B, GLN308D, GLU262B, GLU269B, GLY270B, GLY323D, GLY337D, HIS260B, ILE219B, ILE227B, ILE258B, ILE259B, ILE278D, ILE320D, ILE340D, LEU232D, LEU256B, LEU267B, LEU277D, LEU311D, LEU336D, LEU338D, LYS282D, LYS309D, LYS339D, PHE239D, PHE263B, PRO217B, PRO233D, PRO273D, PRO285B, PRO313D, PRO315D, SER255B, SER266B, SER272D, SER310D, THR237D, TRP324D, VAL284B, VAL314D, VAL325D
• C-D: ARG322D, ASN254C, ASP252C, LYS319D, PRO316D, SER253C, SER255C, SER317D