3KZW

crystal structure of cytosol aminopeptidase from staphylococcus aureus col

• Total interactions analyzed: 66
• Total true interactions: 27
• Strongest Interaction:
  • Chains: J-K
  • Int. Res.: 108
  • Norm. En. per Res.: -4.3956
• Hub Node: A(6)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-87.3931	-43.5348	-298.105	-429.0329	105	10	6	11468	3	47	32
A-C	-84.4789	-41.1426	-314.02	-439.6415	106	11	6	11841	3	46	32
A-D	-16.7575	3.9935	-208.611	-221.375	82	7	9	8799	4	16	13
A-E	-13.4344	17.2157	-109.748	-105.9667	58	4	5	5234	2	19	20
A-G	0.0	-4.2963	-0.3982	-4.6945	5	0	0	62	0	5	4
A-J	0.0	35.1268	-21.695	13.4319	44	0	1	1189	0	14	17
B-C	-69.316	-42.4382	-307.838	-419.5923	105	10	6	11599	3	46	32
B-D	-13.1662	16.2947	-102.446	-99.3175	58	3	5	5056	2	19	20
B-F	-24.9746	3.9691	-194.514	-215.5196	79	8	8	8564	4	16	13
C-E	-26.539	3.955	-210.685	-233.269	81	8	8	8835	4	16	13
C-F	-13.6344	17.2612	-110.025	-106.3982	57	6	5	5250	2	18	20
D-E	-87.8005	-41.3634	-309.379	-438.5429	106	13	6	11734	3	47	32
D-F	-79.857	-40.996	-323.175	-444.0279	107	10	6	11962	3	47	32
D-J	-21.4106	5.9944	-115.128	-130.5443	64	4	2	4931	2	30	30
E-F	-64.5567	-44.5064	-300.555	-409.6181	105	11	6	11499	3	46	33
G-H	-99.4575	-41.8319	-319.45	-460.7394	107	15	6	11987	3	47	34
G-I	-70.8231	-41.8486	-308.416	-421.0877	105	11	6	11693	3	47	32
G-J	-16.7338	3.9164	-192.267	-205.0844	77	9	7	8455	4	16	13
G-L	-10.9049	15.9277	-97.2792	-92.2564	56	4	5	5003	2	18	20
H-I	-82.2556	-42.7569	-310.473	-435.4854	107	12	6	11669	3	46	33
H-K	-11.301	16.4709	-98.3173	-93.1474	58	3	5	4924	2	19	20
H-L	-20.4296	3.9766	-201.205	-217.6579	81	6	8	8631	4	16	13
I-J	-13.7532	17.4138	-111.935	-108.2744	59	6	5	5391	2	18	20
I-K	-19.0654	3.9096	-188.716	-203.8718	80	5	6	8432	4	16	13
J-K	-113.4854	-39.8205	-321.414	-474.7199	108	15	6	12134	3	47	33
J-L	-68.3117	-42.3117	-298.002	-408.6253	104	10	6	11500	3	46	32
K-L	-82.6326	-43.3755	-295.031	-421.0392	107	12	6	11510	3	47	32

Interface residues

• A-B: ALA228A, ALA277B, ALA319A, ALA319B, ALA342A, ALA426A, ASN184B, ASN188B, ASN274B, ASN314B, ASN317A, ASN317B, ASN339A, ASN433A, ASN466B, ASP139B, ASP264B, ASP282B, ASP324A, ASP325A, ASP341A, ASP424A, ASP427A, GLU313B, GLU318A, GLU318B, GLU333A, GLU336A, GLY230B, GLY232B, GLY266A, GLY266B, GLY267A, GLY267B, GLY275A, GLY275B, GLY332A, GLY475B, HIS140B, HIS235B, HIS422A, HIS431A, ILE270A, ILE270B, ILE316A, ILE316B, ILE425A, LEU190B, LEU428A, LYS142B, LYS145B, LYS231A, LYS231B, LYS234B, LYS236B, LYS271A, LYS271B, LYS273B, LYS280B, LYS322A, LYS421A, LYS437A, LYS474B, MET185B, MET276B, MET279B, MET315B, MET321A, MET338A, PHE138B, PHE281B, PHE327A, PRO186B, PRO187B, PRO323A, PRO473B, PRO476B, SER143B, SER144B, SER183B, SER233B, SER265A, SER265B, SER269A, SER320A, SER320B, SER331A, SER423A, THR191B, THR262B, THR272A, THR272B, THR278B, THR328A, THR334A, THR340A, TYR141B, TYR263B, TYR268A, TYR268B, VAL189B, VAL326A, VAL335A, VAL337A, VAL429A
• A-C: ALA228C, ALA277A, ALA319A, ALA319C, ALA342C, ALA426C, ASN184A, ASN188A, ASN274A, ASN314A, ASN317A, ASN317C, ASN339C, ASN433C, ASN466A, ASP139A, ASP181A, ASP264A, ASP282A, ASP324C, ASP325C, ASP341C, ASP424C, ASP427C, GLU137A, GLU313A, GLU318A, GLU318C, GLU333C, GLU336C, GLY230A, GLY232A, GLY266A, GLY266C, GLY267A, GLY267C, GLY275A, GLY275C, GLY332C, GLY475A, HIS140A, HIS235A, HIS422C, HIS431C, ILE270A, ILE270C, ILE316A, ILE316C, ILE425C, LEU190A, LEU428C, LYS142A, LYS145A, LYS231A, LYS231C, LYS234A, LYS236A, LYS271A, LYS271C, LYS273A, LYS280A, LYS322C, LYS421C, LYS437C, LYS474A, MET185A, MET276A, MET279A, MET315A, MET321C, MET338C, PHE138A, PHE281A, PHE327C, PRO186A, PRO187A, PRO323C, PRO473A, PRO476A, SER143A, SER144A, SER183A, SER233A, SER265A, SER265C, SER269C, SER320A, SER320C, SER423C, THR191A, THR262A, THR272A, THR272C, THR278A, THR328C, THR334C, THR340C, TYR141A, TYR263A, TYR268A, TYR268C, VAL189A, VAL326C, VAL335C, VAL337C, VAL429C
• A-D: ALA372A, ALA372D, ALA373A, ALA373D, ALA376A, ALA376D, ALA382A, ALA382D, ALA383A, ALA383D, ALA414A, ALA414D, ALA438A, ALA438D, ARG417A, ARG417D, ASN394A, ASN394D, ASP379A, ASP379D, ASP380A, ASP380D, GLN398A, GLN398D, GLN435A, GLN435D, GLN85A, GLN85D, GLU409A, GLU409D, GLU416A, GLU416D, GLY371A, GLY371D, GLY378A, GLY378D, GLY434A, GLY434D, GLY436A, GLY436D, GLY461A, GLY461D, ILE374A, ILE374D, ILE412A, ILE412D, LEU377A, LEU377D, LEU397A, LEU397D, LEU410A, LEU410D, LEU439A, LEU439D, LYS381A, LYS381D, LYS390A, LYS390D, LYS437A, LYS437D, MET406A, MET406D, PHE385A, PHE385D, PHE408A, PHE408D, PHE440A, PHE440D, PRO411A, PRO411D, SER419A, SER419D, THR370A, THR370D, THR413A, THR413D, THR415A, THR415D, VAL375A, VAL375D, VAL407A, VAL407D
• A-E: ALA61A, ALA61E, ARG43A, ARG43E, ARG70A, ARG70E, ASN14A, ASN14E, ASP63A, ASP63E, GLN47A, GLN47E, GLN67A, GLN67E, GLU101A, GLU101E, HIS102A, HIS102E, HIS46A, HIS46E, HIS48A, HIS48E, ILE103A, ILE103E, ILE49A, ILE49E, ILE50A, ILE50E, ILE57A, ILE57E, ILE72A, ILE72E, LEU44A, LEU44E, LEU71A, LEU71E, LYS467A, LYS467E, LYS56A, LYS56E, PHE62A, PHE62E, SER100A, SER100E, THR15A, THR15E, THR59A, THR59E, THR60A, THR60E, THR68A, THR68E, TYR58A, TYR58E, TYR69A, TYR69E, TYR97A, TYR97E
• A-G: ARG43A, GLU39A, LYS116G, LYS80G, TYR117G
• A-J: ALA252J, ASN388A, ASN394A, ASN394J, ASP118A, ASP164A, ASP248J, ASP250J, ASP395A, ASP395J, GLN119A, GLN119J, GLN26A, GLN359J, GLN398A, GLN490J, GLN491J, GLU162A, GLU162J, GLU251J, ILE161A, ILE161J, ILE392J, LEU120A, LEU120J, LEU160J, LYS116A, LYS247J, LYS390A, LYS390J, LYS80A, PHE165A, PHE165J, PRO453A, SER115A, SER121A, SER121J, SER159A, SER159J, SER389J, TYR117A, VAL303J, VAL391A, VAL391J
• B-C: ALA228B, ALA277C, ALA319B, ALA319C, ALA342B, ALA426B, ASN184C, ASN188C, ASN274C, ASN314C, ASN317B, ASN317C, ASN339B, ASN433B, ASN466C, ASP139C, ASP264C, ASP282C, ASP324B, ASP325B, ASP341B, ASP424B, ASP427B, GLU137C, GLU313C, GLU318B, GLU318C, GLU333B, GLU336B, GLY230C, GLY232C, GLY266B, GLY266C, GLY267B, GLY267C, GLY275B, GLY275C, GLY332B, GLY475C, HIS140C, HIS235C, HIS422B, HIS431B, ILE270B, ILE270C, ILE316B, ILE316C, ILE425B, LEU190C, LEU428B, LYS142C, LYS145C, LYS231B, LYS231C, LYS234C, LYS236C, LYS271B, LYS271C, LYS273C, LYS280C, LYS322B, LYS421B, LYS437B, LYS474C, MET185C, MET276C, MET279C, MET315C, MET321B, MET338B, PHE138C, PHE281C, PHE327B, PRO186C, PRO187C, PRO323B, PRO473C, PRO476C, SER143C, SER144C, SER183C, SER233C, SER265B, SER265C, SER269B, SER320B, SER320C, SER423B, THR191C, THR262C, THR272B, THR272C, THR278C, THR328B, THR334B, THR340B, TYR141C, TYR263C, TYR268B, TYR268C, VAL189C, VAL326B, VAL335B, VAL337B, VAL429B
• B-D: ALA61B, ALA61D, ARG43B, ARG43D, ARG70B, ARG70D, ASN14B, ASN14D, ASP63B, ASP63D, GLN47B, GLN47D, GLN67B, GLN67D, GLU101B, GLU101D, HIS102B, HIS102D, HIS46B, HIS46D, HIS48B, HIS48D, ILE103B, ILE103D, ILE49B, ILE49D, ILE50B, ILE50D, ILE57B, ILE57D, ILE72B, ILE72D, LEU44B, LEU44D, LEU71B, LEU71D, LYS467B, LYS467D, LYS56B, LYS56D, PHE62B, PHE62D, SER100B, SER100D, THR15B, THR15D, THR59B, THR59D, THR60B, THR60D, THR68B, THR68D, TYR58B, TYR58D, TYR69B, TYR69D, TYR97B, TYR97D
• B-F: ALA372B, ALA372F, ALA373B, ALA373F, ALA376B, ALA376F, ALA382B, ALA382F, ALA414B, ALA414F, ALA438B, ALA438F, ARG417B, ARG417F, ASN394B, ASN394F, ASP379B, ASP379F, ASP380B, ASP380F, GLN398B, GLN398F, GLN435B, GLN435F, GLN85B, GLN85F, GLU409B, GLU409F, GLU416B, GLU416F, GLY371B, GLY371F, GLY378B, GLY378F, GLY434B, GLY434F, GLY436B, GLY436F, GLY461B, GLY461F, ILE374B, ILE374F, ILE412B, ILE412F, LEU377B, LEU377F, LEU397B, LEU397F, LEU410B, LEU410F, LEU439B, LEU439F, LYS381B, LYS381F, LYS390B, LYS390F, LYS437B, LYS437F, MET406B, MET406F, PHE385B, PHE385F, PHE408B, PHE408F, PHE440B, PHE440F, PRO411B, PRO411F, SER419B, THR370B, THR370F, THR413B, THR413F, THR415B, THR415F, VAL375B, VAL375F, VAL407B, VAL407F
• C-E: ALA372C, ALA372E, ALA373C, ALA373E, ALA376C, ALA376E, ALA382C, ALA382E, ALA383C, ALA383E, ALA414C, ALA414E, ALA438C, ALA438E, ARG417C, ARG417E, ASN394C, ASN394E, ASP379C, ASP379E, ASP380C, ASP380E, GLN398C, GLN398E, GLN435C, GLN435E, GLN85C, GLN85E, GLU409C, GLU409E, GLU416C, GLU416E, GLY371C, GLY371E, GLY378C, GLY378E, GLY434C, GLY434E, GLY436C, GLY436E, GLY461C, GLY461E, ILE374C, ILE374E, ILE412C, ILE412E, LEU377C, LEU377E, LEU397C, LEU397E, LEU410C, LEU410E, LEU439C, LEU439E, LYS381C, LYS381E, LYS390C, LYS390E, LYS437C, LYS437E, MET406C, MET406E, PHE385C, PHE385E, PHE408C, PHE408E, PHE440C, PHE440E, PRO411C, PRO411E, SER419E, THR370C, THR370E, THR413C, THR413E, THR415C, THR415E, VAL375C, VAL375E, VAL407C, VAL407E
• C-F: ALA61C, ALA61F, ARG43C, ARG43F, ARG70C, ARG70F, ASN14C, ASN14F, ASP63C, ASP63F, GLN47C, GLN47F, GLN67C, GLN67F, GLU101C, GLU101F, HIS102C, HIS102F, HIS46C, HIS46F, HIS48C, HIS48F, ILE103C, ILE103F, ILE49C, ILE49F, ILE50C, ILE50F, ILE57C, ILE72C, ILE72F, LEU44C, LEU44F, LEU71C, LEU71F, LYS467C, LYS467F, LYS56C, LYS56F, PHE62C, PHE62F, SER100C, SER100F, THR15C, THR15F, THR59C, THR59F, THR60C, THR60F, THR68C, THR68F, TYR58C, TYR58F, TYR69C, TYR69F, TYR97C, TYR97F
• D-E: ALA228D, ALA277E, ALA319D, ALA319E, ALA342D, ALA426D, ASN184E, ASN188E, ASN274E, ASN314E, ASN317D, ASN317E, ASN339D, ASN433D, ASN466E, ASP139E, ASP181E, ASP264E, ASP282E, ASP324D, ASP325D, ASP341D, ASP424D, ASP427D, GLU313E, GLU318D, GLU318E, GLU333D, GLU336D, GLY230E, GLY232E, GLY266D, GLY266E, GLY267D, GLY267E, GLY275D, GLY275E, GLY332D, GLY475E, HIS140E, HIS235E, HIS422D, HIS431D, ILE270D, ILE270E, ILE316D, ILE316E, ILE425D, LEU190E, LEU428D, LYS142E, LYS145E, LYS231D, LYS231E, LYS234E, LYS236E, LYS271D, LYS271E, LYS273E, LYS280E, LYS322D, LYS421D, LYS437D, LYS474E, MET185E, MET276E, MET279E, MET315E, MET321D, MET338D, PHE138E, PHE281E, PHE327D, PRO186E, PRO187E, PRO323D, PRO473E, PRO476E, SER143E, SER144E, SER183E, SER233E, SER265D, SER265E, SER269D, SER320D, SER320E, SER331D, SER423D, THR191E, THR262E, THR272D, THR272E, THR278E, THR328D, THR334D, THR340D, TYR141E, TYR263E, TYR268D, TYR268E, VAL189E, VAL326D, VAL335D, VAL337D, VAL429D
• D-F: ALA228F, ALA277D, ALA319D, ALA319F, ALA342F, ALA426F, ASN184D, ASN188D, ASN274D, ASN314D, ASN317D, ASN317F, ASN339F, ASN433F, ASN466D, ASP139D, ASP181D, ASP264D, ASP282D, ASP324F, ASP325F, ASP341F, ASP424F, ASP427F, GLU137D, GLU313D, GLU318D, GLU318F, GLU333F, GLU336F, GLY230D, GLY232D, GLY266D, GLY266F, GLY267D, GLY267F, GLY275D, GLY275F, GLY332F, GLY475D, HIS140D, HIS235D, HIS422F, HIS431F, ILE270D, ILE270F, ILE316D, ILE316F, ILE425F, LEU190D, LEU428F, LYS142D, LYS145D, LYS231D, LYS231F, LYS234D, LYS236D, LYS271D, LYS271F, LYS273D, LYS280D, LYS322F, LYS421F, LYS437F, LYS474D, MET185D, MET276D, MET279D, MET315D, MET321F, MET338F, PHE138D, PHE281D, PHE327F, PRO186D, PRO187D, PRO192D, PRO323F, PRO473D, PRO476D, SER143D, SER144D, SER183D, SER233D, SER265D, SER265F, SER269F, SER320D, SER320F, SER423F, THR191D, THR262D, THR272D, THR272F, THR278D, THR328F, THR334F, THR340F, TYR141D, TYR263D, TYR268D, TYR268F, VAL189D, VAL326F, VAL335F, VAL337F, VAL429F
• D-J: ARG29J, ARG43J, ARG82D, ASN25J, ASN33J, ASN394D, ASN78D, ASN78J, ASP118D, ASP118J, ASP122D, ASP36J, ASP395D, GLN119D, GLN26D, GLN26J, GLN398D, GLN486D, GLN490D, GLN491D, GLN65J, GLU28J, GLU39J, GLU402D, GLU42J, HIS23J, HIS34J, ILE114D, ILE30J, ILE35J, ILE37J, ILE392D, ILE396D, ILE399D, LEU120D, LEU124D, LEU24J, LEU27J, LEU393D, LEU397D, LEU79D, LYS116D, LYS116J, LYS489D, LYS80D, LYS80J, PHE165D, PHE32J, SER115D, SER115J, SER121D, SER31J, SER400D, SER401D, SER40J, SER83D, THR38J, THR81D, TRP487D, TYR117D, TYR117J, VAL123D, VAL391D, VAL64J
• E-F: ALA228E, ALA277F, ALA319E, ALA319F, ALA342E, ALA426E, ASN184F, ASN188F, ASN274F, ASN314F, ASN317E, ASN317F, ASN339E, ASN433E, ASN466F, ASP139F, ASP264F, ASP282F, ASP324E, ASP325E, ASP341E, ASP424E, ASP427E, GLU137F, GLU313F, GLU318E, GLU318F, GLU333E, GLU336E, GLY230F, GLY232F, GLY266E, GLY266F, GLY267E, GLY267F, GLY275E, GLY275F, GLY332E, GLY475F, HIS140F, HIS235F, HIS422E, HIS431E, ILE270E, ILE270F, ILE316E, ILE316F, ILE425E, LEU190F, LEU428E, LYS142F, LYS145F, LYS231E, LYS231F, LYS234F, LYS236F, LYS271E, LYS271F, LYS273F, LYS280F, LYS322E, LYS421E, LYS437E, LYS474F, MET185F, MET276F, MET279F, MET315F, MET321E, MET338E, PHE138F, PHE281F, PHE327E, PRO186F, PRO187F, PRO323E, PRO473F, PRO476F, SER143F, SER144F, SER183F, SER233F, SER265E, SER265F, SER269E, SER320E, SER320F, SER423E, THR191F, THR262F, THR272E, THR272F, THR278F, THR328E, THR334E, THR340E, TYR141F, TYR263F, TYR268E, TYR268F, VAL189F, VAL326E, VAL335E, VAL337E, VAL429E
• G-H: ALA228H, ALA277G, ALA319G, ALA319H, ALA342H, ALA426H, ASN184G, ASN188G, ASN274G, ASN314G, ASN317G, ASN317H, ASN339H, ASN433H, ASN466G, ASP139G, ASP181G, ASP264G, ASP282G, ASP324H, ASP325H, ASP341H, ASP424H, ASP427H, GLU137G, GLU313G, GLU318G, GLU318H, GLU333H, GLU336H, GLY230G, GLY232G, GLY266G, GLY266H, GLY267G, GLY267H, GLY275G, GLY275H, GLY332H, GLY475G, HIS140G, HIS235G, HIS422H, HIS431H, ILE270G, ILE270H, ILE316G, ILE316H, ILE425H, LEU190G, LEU428H, LYS142G, LYS145G, LYS231G, LYS231H, LYS234G, LYS236G, LYS271G, LYS271H, LYS273G, LYS280G, LYS322H, LYS421H, LYS437H, LYS474G, MET185G, MET276G, MET279G, MET315G, MET321H, MET338H, PHE138G, PHE281G, PHE327H, PRO186G, PRO187G, PRO323H, PRO473G, PRO476G, SER143G, SER144G, SER183G, SER233G, SER265G, SER265H, SER269H, SER320G, SER320H, SER423H, THR191G, THR262G, THR272G, THR272H, THR278G, THR328H, THR334H, THR340H, THR465G, TYR141G, TYR263G, TYR268G, TYR268H, VAL189G, VAL326H, VAL335H, VAL337H, VAL429H
• G-I: ALA228G, ALA277I, ALA319G, ALA319I, ALA342G, ALA426G, ASN184I, ASN188I, ASN274I, ASN314I, ASN317G, ASN317I, ASN339G, ASN433G, ASN466I, ASP139I, ASP264I, ASP282I, ASP324G, ASP325G, ASP341G, ASP424G, ASP427G, GLU137I, GLU313I, GLU318G, GLU318I, GLU333G, GLU336G, GLY230I, GLY232I, GLY266G, GLY266I, GLY267G, GLY267I, GLY275G, GLY275I, GLY332G, GLY475I, HIS140I, HIS235I, HIS422G, HIS431G, ILE270G, ILE270I, ILE316G, ILE316I, ILE425G, LEU190I, LEU428G, LYS142I, LYS145I, LYS231G, LYS231I, LYS234I, LYS236I, LYS271G, LYS271I, LYS273I, LYS280I, LYS322G, LYS421G, LYS437G, LYS474I, MET185I, MET276I, MET279I, MET315I, MET321G, MET338G, PHE138I, PHE281I, PHE327G, PRO186I, PRO187I, PRO323G, PRO473I, PRO476I, SER143I, SER144I, SER183I, SER233I, SER265G, SER265I, SER269G, SER320G, SER320I, SER423G, THR191I, THR262I, THR272G, THR272I, THR278I, THR328G, THR334G, THR340G, TYR141I, TYR263I, TYR268G, TYR268I, VAL189I, VAL326G, VAL335G, VAL337G, VAL429G
• G-J: ALA372G, ALA372J, ALA373G, ALA373J, ALA376G, ALA376J, ALA382G, ALA382J, ALA414G, ALA414J, ALA438G, ALA438J, ARG417G, ARG417J, ASN394G, ASN394J, ASP379G, ASP379J, ASP380G, ASP380J, GLN398G, GLN398J, GLN435G, GLN435J, GLN85G, GLN85J, GLU409G, GLU409J, GLU416G, GLU416J, GLY371G, GLY371J, GLY378G, GLY378J, GLY434G, GLY434J, GLY436G, GLY436J, GLY461G, GLY461J, ILE374G, ILE374J, ILE412G, ILE412J, LEU377G, LEU377J, LEU397G, LEU410G, LEU410J, LEU439G, LEU439J, LYS381G, LYS381J, LYS390G, LYS390J, LYS437G, LYS437J, MET406G, MET406J, PHE385G, PHE385J, PHE408G, PHE408J, PHE440G, PHE440J, PRO411G, PRO411J, THR370G, THR370J, THR413G, THR413J, THR415G, THR415J, VAL375G, VAL375J, VAL407G, VAL407J
• G-L: ALA61G, ALA61L, ARG43G, ARG43L, ARG70G, ARG70L, ASN14G, ASN14L, ASP63G, ASP63L, GLN47G, GLN47L, GLN67G, GLN67L, GLU101G, GLU101L, HIS102G, HIS102L, HIS46G, HIS46L, HIS48G, HIS48L, ILE103G, ILE103L, ILE49G, ILE49L, ILE50G, ILE50L, ILE72G, ILE72L, LEU44G, LEU44L, LEU71G, LEU71L, LYS467G, LYS467L, LYS56G, LYS56L, PHE62G, PHE62L, SER100G, SER100L, THR15G, THR15L, THR59G, THR59L, THR60G, THR60L, THR68G, THR68L, TYR58G, TYR58L, TYR69G, TYR69L, TYR97G, TYR97L
• H-I: ALA228I, ALA277H, ALA319H, ALA319I, ALA342I, ALA426I, ASN184H, ASN188H, ASN274H, ASN314H, ASN317H, ASN317I, ASN339I, ASN433I, ASN466H, ASP139H, ASP264H, ASP282H, ASP324I, ASP325I, ASP341I, ASP424I, ASP427I, GLU137H, GLU313H, GLU318H, GLU318I, GLU333I, GLU336I, GLY230H, GLY232H, GLY266H, GLY266I, GLY267H, GLY267I, GLY275H, GLY275I, GLY332I, GLY475H, HIS140H, HIS235H, HIS422I, HIS431I, ILE270H, ILE270I, ILE316H, ILE316I, ILE425I, LEU190H, LEU428I, LYS142H, LYS145H, LYS231H, LYS231I, LYS234H, LYS236H, LYS271H, LYS271I, LYS273H, LYS280H, LYS322I, LYS421I, LYS437I, LYS474H, MET185H, MET276H, MET279H, MET315H, MET321I, MET338I, PHE138H, PHE281H, PHE327I, PRO186H, PRO187H, PRO323I, PRO473H, PRO476H, SER143H, SER144H, SER183H, SER233H, SER265H, SER265I, SER269I, SER320H, SER320I, SER331I, SER423I, THR191H, THR262H, THR272H, THR272I, THR278H, THR328I, THR334I, THR340I, THR465H, TYR141H, TYR263H, TYR268H, TYR268I, VAL189H, VAL326I, VAL335I, VAL337I, VAL429I
• H-K: ALA61H, ALA61K, ARG43H, ARG43K, ARG70H, ARG70K, ASN14H, ASN14K, ASP63H, ASP63K, GLN47H, GLN47K, GLN67H, GLN67K, GLU101H, GLU101K, HIS102H, HIS102K, HIS46H, HIS46K, HIS48H, HIS48K, ILE103H, ILE103K, ILE49H, ILE49K, ILE50H, ILE50K, ILE57H, ILE57K, ILE72H, ILE72K, LEU44H, LEU44K, LEU71H, LEU71K, LYS467H, LYS467K, LYS56H, LYS56K, PHE62H, PHE62K, SER100H, SER100K, THR15H, THR15K, THR59H, THR59K, THR60H, THR60K, THR68H, THR68K, TYR58H, TYR58K, TYR69H, TYR69K, TYR97H, TYR97K
• H-L: ALA372H, ALA372L, ALA373H, ALA373L, ALA376H, ALA376L, ALA382H, ALA382L, ALA383H, ALA414H, ALA414L, ALA438H, ALA438L, ARG417H, ARG417L, ASN394H, ASN394L, ASP379H, ASP379L, ASP380H, ASP380L, GLN398H, GLN398L, GLN435H, GLN435L, GLN85H, GLN85L, GLU409H, GLU409L, GLU416H, GLU416L, GLY371H, GLY371L, GLY378H, GLY378L, GLY434H, GLY434L, GLY436H, GLY436L, GLY461H, GLY461L, ILE374H, ILE374L, ILE412H, ILE412L, LEU377H, LEU377L, LEU397H, LEU397L, LEU410H, LEU410L, LEU439H, LEU439L, LYS381H, LYS381L, LYS390H, LYS390L, LYS437H, LYS437L, MET406H, MET406L, PHE385H, PHE385L, PHE408H, PHE408L, PHE440H, PHE440L, PRO411H, PRO411L, SER419H, SER419L, THR370H, THR370L, THR413H, THR413L, THR415H, THR415L, VAL375H, VAL375L, VAL407H, VAL407L
• I-J: ALA61I, ALA61J, ARG43I, ARG43J, ARG70I, ARG70J, ASN14I, ASN14J, ASP63I, ASP63J, GLN47I, GLN47J, GLN67I, GLN67J, GLU101I, GLU101J, HIS102I, HIS102J, HIS46I, HIS46J, HIS48I, HIS48J, ILE103I, ILE103J, ILE49I, ILE49J, ILE50I, ILE50J, ILE57I, ILE57J, ILE72I, ILE72J, LEU44I, LEU44J, LEU71I, LEU71J, LYS467I, LYS467J, LYS53I, LYS56I, LYS56J, PHE62I, PHE62J, SER100I, SER100J, THR15I, THR15J, THR59I, THR59J, THR60I, THR60J, THR68I, THR68J, TYR58I, TYR58J, TYR69I, TYR69J, TYR97I, TYR97J
• I-K: ALA372I, ALA372K, ALA373I, ALA373K, ALA376I, ALA376K, ALA382I, ALA382K, ALA414I, ALA414K, ALA438I, ALA438K, ARG417I, ARG417K, ASN394I, ASN394K, ASP379I, ASP379K, ASP380I, ASP380K, GLN398I, GLN398K, GLN435I, GLN435K, GLN85I, GLN85K, GLU409I, GLU409K, GLU416I, GLU416K, GLY371I, GLY371K, GLY378I, GLY378K, GLY434I, GLY434K, GLY436I, GLY436K, GLY461I, GLY461K, ILE374I, ILE374K, ILE412I, ILE412K, LEU377I, LEU377K, LEU397I, LEU397K, LEU410I, LEU410K, LEU439I, LEU439K, LYS381I, LYS381K, LYS390I, LYS390K, LYS437I, LYS437K, MET406I, MET406K, PHE385I, PHE385K, PHE408I, PHE408K, PHE440I, PHE440K, PRO411I, PRO411K, SER419I, SER419K, THR370I, THR370K, THR413I, THR413K, THR415I, THR415K, VAL375I, VAL375K, VAL407I, VAL407K
• J-K: ALA228K, ALA277J, ALA319J, ALA319K, ALA342K, ALA426K, ASN184J, ASN188J, ASN274J, ASN314J, ASN317J, ASN317K, ASN339K, ASN433K, ASN466J, ASP139J, ASP181J, ASP264J, ASP282J, ASP324K, ASP325K, ASP341K, ASP424K, ASP427K, GLU137J, GLU313J, GLU318J, GLU318K, GLU333K, GLU336K, GLY230J, GLY232J, GLY266J, GLY266K, GLY267J, GLY267K, GLY275J, GLY275K, GLY332K, GLY475J, HIS140J, HIS235J, HIS422K, HIS431K, ILE270J, ILE270K, ILE316J, ILE316K, ILE425K, LEU190J, LEU428K, LYS142J, LYS145J, LYS231J, LYS231K, LYS234J, LYS236J, LYS271J, LYS271K, LYS273J, LYS280J, LYS322K, LYS421K, LYS437K, LYS474J, MET185J, MET276J, MET279J, MET315J, MET321K, MET338K, PHE138J, PHE281J, PHE327K, PRO186J, PRO187J, PRO192J, PRO323K, PRO473J, PRO476J, SER143J, SER144J, SER183J, SER233J, SER265J, SER265K, SER269K, SER320J, SER320K, SER423K, THR191J, THR262J, THR272J, THR272K, THR278J, THR328K, THR334K, THR340K, THR465J, TYR141J, TYR263J, TYR268J, TYR268K, VAL189J, VAL326K, VAL335K, VAL337K, VAL429K
• J-L: ALA228J, ALA277L, ALA319J, ALA319L, ALA342J, ALA426J, ASN184L, ASN188L, ASN274L, ASN314L, ASN317J, ASN317L, ASN339J, ASN433J, ASN466L, ASP139L, ASP264L, ASP282L, ASP324J, ASP325J, ASP341J, ASP424J, ASP427J, GLU313L, GLU318J, GLU318L, GLU333J, GLU336J, GLY230L, GLY232L, GLY266J, GLY266L, GLY267J, GLY267L, GLY275J, GLY275L, GLY332J, GLY475L, HIS140L, HIS235L, HIS422J, HIS431J, ILE270J, ILE270L, ILE316J, ILE316L, ILE425J, LEU190L, LEU428J, LYS142L, LYS145L, LYS231J, LYS231L, LYS234L, LYS236L, LYS271J, LYS271L, LYS273L, LYS280L, LYS322J, LYS421J, LYS437J, LYS474L, MET185L, MET276L, MET279L, MET315L, MET321J, MET338J, PHE138L, PHE281L, PHE327J, PRO186L, PRO187L, PRO323J, PRO473L, PRO476L, SER143L, SER144L, SER183L, SER233L, SER265J, SER265L, SER269J, SER320J, SER320L, SER423J, THR191L, THR262L, THR272J, THR272L, THR278L, THR328J, THR334J, THR340J, TYR141L, TYR263L, TYR268J, TYR268L, VAL189L, VAL326J, VAL335J, VAL337J, VAL429J
• K-L: ALA228L, ALA277K, ALA319K, ALA319L, ALA342L, ALA426L, ASN184K, ASN188K, ASN274K, ASN314K, ASN317K, ASN317L, ASN339L, ASN433L, ASN466K, ASP139K, ASP264K, ASP282K, ASP324L, ASP325L, ASP341L, ASP424L, ASP427L, GLU137K, GLU313K, GLU318K, GLU318L, GLU333L, GLU336L, GLY230K, GLY232K, GLY266K, GLY266L, GLY267K, GLY267L, GLY275K, GLY275L, GLY332L, GLY475K, HIS140K, HIS235K, HIS422L, HIS431L, ILE270K, ILE270L, ILE316K, ILE316L, ILE425L, LEU190K, LEU428L, LYS142K, LYS145K, LYS231K, LYS231L, LYS234K, LYS236K, LYS271K, LYS271L, LYS273K, LYS280K, LYS322L, LYS421L, LYS437L, LYS474K, MET185K, MET276K, MET279K, MET315K, MET321L, MET338L, PHE138K, PHE281K, PHE327L, PRO186K, PRO187K, PRO323L, PRO473K, PRO476K, SER143K, SER144K, SER183K, SER233K, SER265K, SER265L, SER269L, SER320K, SER320L, SER331L, SER423L, THR191K, THR262K, THR272K, THR272L, THR278K, THR328L, THR334L, THR340L, THR465K, TYR141K, TYR263K, TYR268K, TYR268L, VAL189K, VAL326L, VAL335L, VAL337L, VAL429L