3KZ4

crystal structure of the rotavirus double layered particle

• Total interactions analyzed: 105
• Total true interactions: 40
• Strongest Interaction:
  • Chains: I-K
  • Int. Res.: 245
  • Norm. En. per Res.: -3.2176
• Hub Node: B(9)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-23.156	-84.4989	-292.023	-399.6779	156	52	2	15522	8	57	41
A-F	-12.0229	0.0	-38.6911	-50.714	38	11	0	1861	0	1	2
A-G	0.0	0.0	-47.0699	-47.0699	43	3	1	2626	0	2	1
A-J	0.0	0.0	-0.1883	-0.1883	4	0	0	44	0	0	0
A-K	0.0	0.0	-4.3342	-4.3342	23	1	0	428	0	0	1
B-D	-2.8641	0.0	-60.7409	-63.605	43	6	1	2588	0	0	1
B-H	0.0	-17.7207	-94.451	-112.1717	52	7	0	4999	0	2	1
B-I	-18.009	13.954	-143.581	-147.636	99	34	3	8696	0	8	7
B-J	-35.9375	0.0	-66.4319	-102.3694	48	28	0	4549	0	4	3
B-K	0.0	0.0	-5.6921	-5.6921	23	0	0	401	1	4	2
B-L	0.0	0.0	-63.0394	-63.0394	45	6	1	3520	0	1	2
B-M	0.0	0.0	-29.2916	-29.2916	45	1	1	2176	0	1	6
B-N	0.0	0.0	-70.0213	-70.0213	65	11	0	4105	0	6	5
B-O	0.0	-1.1719			2
C-D	-63.6668	-71.9322	-584.969	-720.568	243	32	13	25288	12	69	65
C-E	-78.2824	-65.6698	-580.241	-724.1932	243	33	13	25126	10	69	64
C-L	-24.1419	-74.68	-47.0396	-145.8615	60	1	0	2543	1	24	17
C-N	-4.0984	-16.417	-75.3469	-95.8622	65	6	0	3870	2	13	15
D-E	-68.4485	-79.6031	-586.334	-734.3856	243	36	13	25295	10	70	66
D-L	-4.7743	44.3642	-34.7899	4.8	21	7	1	1283	0	6	9
D-N	0.0	0.0	-2.8435	-2.8435	13	0	0	282	0	12	4
F-G	-53.337	-37.5232	-573.175	-664.0352	245	29	13	25046	10	71	64
F-H	-50.3282	-27.354	-563.031	-640.7132	240	41	13	24931	9	68	63
G-H	-64.7403	-62.3836	-606.157	-733.2809	245	29	13	25392	9	71	66
G-I	-6.5477	-25.3562	-86.8381	-118.7419	96	9	0	5289	2	24	25
G-J	0.0	-31.3188	-19.3691	-50.6879	36	0	0	1012	1	19	9
H-I	0.0	-32.7527	-11.679	-44.4317	26	8	0	847	1	17	8
H-J	0.0	54.1203	-32.102	22.0183	23	9	1	1381	0	6	10
I-J	-52.5639	-50.9915	-582.607	-686.1624	242	36	14	25328	12	69	66
I-K	-94.0803	-80.7633	-613.471	-788.3146	245	32	13	25893	12	70	63
I-L	0.0	-5.9867	-6.0655	-12.0522	25	0	0	602	0	13	5
I-M	-6.0066	51.6875	-25.5194	20.1614	23	13	1	1665	0	6	10
J-K	-57.1295	-27.1718	-571.26	-655.5612	242	39	13	24914	9	68	64
K-L	-9.2101	-23.6653	-70.0699	-102.9454	71	3	0	3563	2	19	16
K-M	-13.2756	-44.2868	-47.6192	-105.1816	56	4	0	2631	3	25	18
L-M	-72.9266	-81.895	-604.877	-759.6986	242	32	13	25544	11	71	63
L-N	-78.8141	-57.651	-569.317	-705.7821	229	37	13	24110	9	60	55
M-N	-44.7785	-33.3209	-410.862	-488.9613	192	30	10	17666	8	51	51
M-O	0.0	-27.2628			6
N-O	0.0	50.5054			6

Interface residues

• A-B: ALA344B, ALA357B, ALA591B, ALA628A, ALA640A, ALA655A, ALA745A, ALA860B, ARG279B, ARG290B, ARG421A, ARG444B, ARG527B, ARG531B, ARG539B, ARG548B, ARG656A, ARG664A, ARG666A, ARG668A, ARG670A, ARG740A, ARG790A, ARG875B, ASN280B, ASN283B, ASN287B, ASN313A, ASN538B, ASN590B, ASN629A, ASN632A, ASN867B, ASN873B, ASN878B, ASP281B, ASP289B, ASP312A, ASP319A, ASP352B, ASP451A, ASP524B, ASP545B, ASP653A, ASP659A, ASP660A, ASP667A, ASP743A, ASP861B, GLN345B, GLN347B, GLN351B, GLN354B, GLN453A, GLN530B, GLN542B, GLN569A, GLN635A, GLN661A, GLU315A, GLU338B, GLU343B, GLU422A, GLU736A, GLU864B, GLU879B, GLY450A, GLY541B, GLY589B, GLY742A, HIS311A, ILE278B, ILE285B, ILE346B, ILE420A, ILE533B, ILE588B, ILE625A, ILE641A, ILE866B, LEU286B, LEU317A, LEU339B, LEU353B, LEU355B, LEU358B, LEU510B, LEU534B, LEU535B, LEU536B, LEU540B, LEU571A, LEU587B, LEU633A, LEU665A, LEU738A, LEU789A, LEU880B, LYS348B, LYS526B, LYS636A, LYS637A, LYS639A, LYS788A, LYS791A, MET288B, MET349B, MET521B, MET586B, MET638A, MET662A, MET739A, PHE314A, PHE419A, PHE518B, PHE652A, PRO452A, PRO519B, PRO522B, PRO658A, PRO865B, SER316A, SER341B, SER350B, SER423A, SER514B, SER528B, SER537B, SER859B, THR320A, THR342B, THR391A, THR520B, THR570A, THR572A, THR573A, THR741A, THR748A, THR862B, TRP318A, TYR160A, TYR284B, TYR525B, TYR634A, TYR663A, TYR744A, VAL282B, VAL340B, VAL425A, VAL523B, VAL568A, VAL654A, VAL657A, VAL787A, VAL863B, VAL869B
• A-F: ALA459A, ALA469A, ARG126F, ARG444A, ARG448A, ASN35F, ASN465A, ASN470A, ASP29F, GLN32F, GLN36F, GLN453A, GLN457A, GLN461A, GLN462A, GLN464A, GLU460A, GLY67F, HIS473A, ILE31F, ILE38F, ILE39F, ILE458A, ILE463A, LEU65F, LEU66F, LEU70F, LEU71F, MET442A, MET445A, PHE466A, SER25F, SER28F, THR40F, THR68F, THR69F, TYR24F, TYR447A
• A-G: ALA469A, ARG481A, ARG498A, ASN26G, ASN465A, ASN470A, ASN476A, ASN477A, ASN478A, ASN496A, ASN499A, ASN72G, ASN76G, ASP74G, GLN32G, GLN457A, GLN461A, GLN464A, GLN467A, GLN479A, GLN482A, GLN505A, GLU460A, GLU508A, GLY64G, GLY67G, HIS473A, ILE497A, LEU23G, LEU472A, LEU65G, LEU70G, LEU71G, PHE466A, PHE474A, SER25G, SER28G, THR68G, THR69G, TRP471A, TYR24G, VAL468A, VAL475A
• A-J: ARG126J, ARG630A, LEU65J, LEU671A
• A-K: ARG740A, ASN632A, ASN734A, ASN76K, ASP62K, GLN731A, GLN732A, GLN746A, GLN755A, GLU737A, GLY64K, GLY67K, LEU65K, LEU66K, LEU70K, LEU71K, PHE63K, THR68K, THR69K, THR741A, THR80K, TYR634A, TYR744A
• B-D: ALA745B, ARG126D, ARG708B, ASN35D, ASN42D, ASN44D, ASN734B, ASN749B, ASN753B, ASP62D, ASP743B, GLN32D, GLN36D, GLN731B, GLN732B, GLN746B, GLN755B, GLU45D, GLU737B, GLY43D, GLY64D, GLY67D, GLY729B, ILE38D, ILE39D, ILE733B, ILE747B, LEU65D, LEU66D, LEU738B, LYS123D, MET41D, MET750B, PHE61D, PHE63D, PHE730B, PRO756B, THR40D, THR68D, THR741B, THR748B, TYR744B, VAL757B
• B-H: ALA439B, ALA459B, ALA469B, ALA81H, ARG444B, ARG515B, ASN35H, ASN42H, ASN465B, ASN76H, ASN83H, ASP62H, ASP74H, GLN32H, GLN443B, GLN461B, GLN462B, GLN464B, GLN467B, GLN516B, GLN517B, GLU460B, GLU79H, GLY441B, GLY64H, GLY67H, ILE38H, ILE39H, ILE458B, ILE463B, LEU65H, LEU66H, LEU70H, LEU71H, MET442B, MET445B, PHE34H, PHE440B, PHE466B, PHE518B, PHE63H, PRO438B, PRO519B, SER514B, THR68H, THR69H, THR80H, THR84H, TYR24H, TYR437B, TYR77H, VAL468B
• B-I: ALA469B, ALA551B, ALA870B, ARG126I, ARG277B, ARG279B, ARG481B, ARG498B, ASN280B, ASN35I, ASN42I, ASN44I, ASN470B, ASN476B, ASN477B, ASN478B, ASN490B, ASN494B, ASN496B, ASN499B, ASN504B, ASN72I, ASN76I, ASN873B, ASP281B, ASP29I, ASP486B, ASP495B, ASP74I, ASP872B, GLN32I, GLN33I, GLN36I, GLN457B, GLN461B, GLN464B, GLN467B, GLN479B, GLN482B, GLN505B, GLU276B, GLU460B, GLU508B, GLU555B, GLY487B, GLY500B, GLY64I, GLY67I, HIS473B, HIS501B, ILE278B, ILE31I, ILE38I, ILE39I, ILE463B, ILE485B, ILE497B, ILE503B, LEU122I, LEU23I, LEU30I, LEU472B, LEU489B, LEU493B, LEU65I, LEU66I, LEU70I, LEU71I, LYS123I, LYS125I, MET41I, MET558B, PHE124I, PHE34I, PHE466B, PHE474B, PHE480B, PHE63I, PHE871B, PRO275B, SER25I, SER28I, THR40I, THR556B, THR68I, THR69I, THR80I, TRP471B, TYR24I, TYR552B, TYR554B, TYR77I, VAL27I, VAL468B, VAL475B, VAL483B, VAL484B, VAL488B, VAL502B
• B-J: ALA509B, ALA75J, ARG481B, ARG498B, ARG515B, ASN26J, ASN465B, ASN470B, ASN496B, ASN504B, ASN72J, ASN76J, ASP74J, GLN32J, GLN467B, GLN505B, GLN512B, GLU20J, GLU508B, GLY21J, GLY67J, HIS473B, ILE497B, ILE503B, LEU23J, LEU506B, LEU510B, LEU540B, LEU70J, LEU71J, LEU73J, MET507B, MET511B, MET874B, PHE466B, PHE474B, SER25J, SER28J, SER514B, THR22J, THR68J, THR69J, TRP471B, TYR24J, TYR77J, VAL27J, VAL468B, VAL502B
• B-K: ALA870B, ARG126K, ARG279B, ASN280B, ASN873B, ASP29K, ASP872B, GLN32K, GLN36K, GLU276B, GLY487B, ILE31K, ILE39K, LEU71K, MET874B, PHE871B, SER25K, SER28K, THR68K, THR69K, TYR24K, VAL282B, VAL869B
• B-L: ALA627B, ALA628B, ARG126L, ARG307B, ARG630B, ARG668B, ARG670B, ASN309B, ASN35L, ASN629B, ASN632B, ASN683B, ASN72L, ASP29L, ASP667B, ASP74L, GLN32L, GLN566B, GLY67L, ILE31L, ILE39L, ILE625B, LEU23L, LEU631B, LEU65L, LEU669B, LEU66L, LEU671B, LEU672B, LEU679B, LEU686B, LEU70L, LEU71L, LEU73L, LYS637B, PHE682B, PRO673B, SER25L, SER28L, THR626B, THR68L, THR69L, TYR24L, VAL622B, VAL674B
• B-M: ARG126M, ARG236B, ARG300B, ARG307B, ASN302B, ASN309B, ASN564B, ASN615B, ASN72M, ASN76M, ASP29M, ASP306B, ASP486B, ASP74M, GLN258B, GLN305B, GLN32M, GLU263B, GLY67M, HIS259B, ILE485B, LEU23M, LEU303B, LEU304B, LEU308B, LEU489B, LEU65M, LEU66M, LEU671B, LEU672B, LEU70M, LEU71M, LYS123M, PRO301B, PRO673B, SER25M, SER28M, THR68M, THR69M, THR843B, TYR24M, TYR77M, VAL488B, VAL674B, VAL676B
• B-N: ALA251B, ARG126N, ARG630B, ARG694B, ASN253B, ASN35N, ASN44N, ASN632B, ASN683B, ASN688B, ASN726B, ASN72N, ASN76N, ASP249B, ASP29N, ASP680B, ASP690B, ASP728B, ASP74N, GLN258B, GLN260B, GLN32N, GLN36N, GLN691B, GLN732B, GLU254B, GLY43N, GLY64N, GLY67N, HIS259B, HIS840B, ILE248B, ILE31N, ILE38N, ILE39N, ILE681B, ILE685B, LEU23N, LEU257B, LEU65N, LEU66N, LEU679B, LEU684B, LEU686B, LEU70N, LEU71N, LEU727B, LEU73N, LYS123N, MET687B, MET689B, PHE252B, PHE256B, PHE682B, PRO247B, SER25N, SER28N, THR68N, THR69N, THR843B, TYR24N, TYR250B, TYR255B, TYR77N, VAL676B
• B-O: ASP74O, HIS840B
• C-D: ALA14D, ALA162D, ALA172D, ALA184D, ALA221C, ALA229C, ALA229D, ALA244D, ALA275C, ALA282C, ALA303C, ALA305C, ALA306C, ALA318C, ALA329C, ALA336D, ALA338C, ALA338D, ALA344D, ALA354D, ALA75D, ALA81D, ARG126C, ARG144C, ARG147C, ARG15D, ARG231C, ARG231D, ARG236D, ARG255C, ARG276C, ARG283C, ARG296C, ARG325C, ARG325D, ARG350D, ARG392D, ARG82D, ASN128C, ASN131C, ASN138C, ASN140C, ASN143C, ASN156D, ASN183D, ASN239D, ASN250C, ASN250D, ASN26D, ASN271C, ASN284C, ASN299C, ASN345D, ASN35C, ASN366D, ASN72D, ASN83D, ASP130C, ASP13C, ASP13D, ASP16D, ASP174D, ASP228C, ASP29C, ASP29D, ASP2C, ASP337D, ASP369D, ASP74D, ASP86D, ASP93D, CYS197C, CYS331C, GLN146C, GLN170D, GLN189D, GLN32C, GLN33C, GLN351D, GLN36C, GLU134C, GLU137C, GLU187D, GLU20D, GLU230C, GLU230D, GLU315D, GLU327C, GLU327D, GLU332C, GLU340D, GLU352D, GLU79D, GLY149C, GLY185D, GLY21D, GLY243D, GLY278C, GLY321C, GLY364D, HIS153C, HIS153D, HIS173D, HIS316C, HIS317C, HIS317D, ILE127C, ILE136C, ILE18D, ILE223C, ILE238D, ILE253C, ILE270C, ILE280C, ILE281C, ILE31C, ILE326C, ILE371D, ILE39C, ILE85D, LEU122C, LEU141C, LEU176D, LEU182D, LEU225C, LEU226C, LEU23D, LEU254C, LEU294C, LEU307C, LEU30C, LEU30D, LEU322C, LEU343D, LEU395D, LEU70D, LEU71D, LEU73D, LYS125C, LYS12D, LYS154C, LYS154D, LYS17C, LYS17D, LYS397D, LYS9C, LYS9D, MET295C, MET300C, MET342D, MET365D, MET37C, MET394D, PHE124C, PHE129C, PHE150C, PHE152C, PHE158D, PHE232C, PHE232D, PHE234C, PHE234D, PHE249D, PHE277C, PHE308C, PHE314D, PHE34C, PRO155C, PRO159D, PRO171D, PRO227C, PRO235C, PRO235D, PRO251C, PRO251D, PRO256C, PRO297C, PRO298C, PRO302C, PRO313D, PRO362D, PRO363D, SER132C, SER133C, SER161D, SER186C, SER186D, SER233C, SER233D, SER240D, SER25C, SER25D, SER28C, SER28D, SER328C, SER339C, SER339D, SER348D, SER393D, SER6C, THR148C, THR151C, THR219C, THR220C, THR222C, THR224C, THR22D, THR245D, THR246D, THR272C, THR279C, THR301C, THR319C, THR323C, THR341D, THR347D, THR368D, THR40C, THR84D, TRP139C, TRP247D, TRP367D, TYR135C, TYR160D, TYR195D, TYR248D, TYR24D, TYR273C, TYR353D, TYR5C, VAL19D, VAL237D, VAL252C, VAL27D, VAL304C, VAL320C, VAL330C, VAL346D, VAL349D, VAL396D, VAL3C, VAL78D, VAL89D
• C-E: ALA14C, ALA162C, ALA172C, ALA184C, ALA221E, ALA229C, ALA229E, ALA244C, ALA275E, ALA282E, ALA303E, ALA305E, ALA306E, ALA318E, ALA329E, ALA336C, ALA338C, ALA338E, ALA344C, ALA354C, ALA75C, ALA81C, ARG126E, ARG144E, ARG147E, ARG15C, ARG231C, ARG231E, ARG236C, ARG255E, ARG276E, ARG283E, ARG296E, ARG325C, ARG325E, ARG350C, ARG392C, ARG82C, ASN128E, ASN131E, ASN138E, ASN140E, ASN143E, ASN156C, ASN183C, ASN239C, ASN250C, ASN250E, ASN26C, ASN271E, ASN284E, ASN299E, ASN345C, ASN35E, ASN366C, ASN72C, ASN83C, ASP130E, ASP13C, ASP13E, ASP16C, ASP174C, ASP228E, ASP29C, ASP29E, ASP2E, ASP337C, ASP369C, ASP74C, ASP86C, ASP93C, CYS197E, CYS331E, GLN142E, GLN146E, GLN170C, GLN189C, GLN32E, GLN33E, GLN351C, GLN36E, GLU134E, GLU137E, GLU187C, GLU187E, GLU20C, GLU230C, GLU230E, GLU315C, GLU327C, GLU327E, GLU332E, GLU340C, GLU352C, GLU79C, GLY149E, GLY185C, GLY21C, GLY243C, GLY278E, GLY321E, GLY364C, HIS153C, HIS153E, HIS173C, HIS316E, HIS317C, HIS317E, ILE127E, ILE136E, ILE18C, ILE223E, ILE238C, ILE253E, ILE270E, ILE280E, ILE281E, ILE31E, ILE326E, ILE371C, ILE39E, ILE85C, LEU122E, LEU141E, LEU176C, LEU182C, LEU225E, LEU226E, LEU23C, LEU254E, LEU294E, LEU307E, LEU30C, LEU30E, LEU322E, LEU343C, LEU395C, LEU71C, LEU73C, LYS125E, LYS12C, LYS154C, LYS154E, LYS17C, LYS17E, LYS397C, LYS9C, LYS9E, MET295E, MET300E, MET342C, MET365C, MET37E, MET394C, PHE124E, PHE129E, PHE150E, PHE152E, PHE158C, PHE232C, PHE232E, PHE234C, PHE234E, PHE249C, PHE277E, PHE308E, PHE314C, PHE34E, PRO155C, PRO155E, PRO159C, PRO171C, PRO227E, PRO235C, PRO235E, PRO251C, PRO251E, PRO256E, PRO297E, PRO298E, PRO302E, PRO313C, PRO362C, PRO363C, SER132E, SER133E, SER161C, SER186C, SER186E, SER233C, SER233E, SER240C, SER25C, SER28C, SER28E, SER328E, SER339C, SER339E, SER348C, SER393C, SER6E, THR148E, THR151E, THR219E, THR220E, THR222E, THR224E, THR22C, THR245C, THR246C, THR272E, THR279E, THR301E, THR319E, THR323E, THR341C, THR347C, THR368C, THR40E, TRP139E, TRP247C, TRP367C, TYR135E, TYR160C, TYR195C, TYR248C, TYR24C, TYR273E, TYR353C, TYR5E, VAL19C, VAL237C, VAL252E, VAL27C, VAL304E, VAL320E, VAL330E, VAL346C, VAL349C, VAL396C, VAL3E, VAL78C, VAL89C
• C-L: ALA110C, ALA81L, ARG102C, ARG106C, ARG117C, ARG15L, ARG392L, ARG57L, ARG82L, ASN107C, ASN53L, ASN58L, ASN60L, ASN76L, ASN83L, ASN94L, ASP114C, ASP62L, ASP86L, ASP90L, ASP93L, GLN105C, GLN112C, GLN47C, GLU352L, GLU45C, GLU79L, GLY121C, GLY64L, ILE56L, ILE85L, LEU119C, LEU122C, LEU54L, LYS118C, LYS123C, LYS125C, LYS397L, MET1C, MET97L, PHE124C, PHE63L, PHE88L, PHE91L, PRO111C, PRO359C, PRO55L, SER104C, SER113C, SER120C, THR80L, THR84L, TRP59L, TYR353L, TYR87L, VAL349L, VAL396L, VAL3C, VAL78L, VAL89L
• C-N: ALA110C, ALA110N, ARG106C, ARG106N, ARG117C, ARG144C, ARG144N, ARG145C, ARG145N, ARG147C, ARG147N, ARG216N, ARG283N, ARG378C, ASN107C, ASN107N, ASN140C, ASN140N, ASN143C, ASN143N, ASN266C, ASN266N, ASN284C, ASN284N, ASN373C, ASP286N, ASP369C, ASP380C, GLN105C, GLN105N, GLN142C, GLN142N, GLN146C, GLN146N, GLN268C, GLN268N, GLN383C, GLU379C, GLY108C, GLY267N, GLY358C, ILE109C, ILE109N, ILE270C, ILE270N, LEU141N, LEU265C, LEU265N, LEU370C, PRO111N, PRO359C, PRO362C, PRO363C, PRO376C, SER375C, SER377C, THR148N, THR219N, THR372C, TRP139C, TRP139N, TYR374C, VAL217N, VAL357C, VAL360C
• D-E: ALA14E, ALA162E, ALA172E, ALA184E, ALA221D, ALA229D, ALA229E, ALA244E, ALA275D, ALA282D, ALA303D, ALA305D, ALA306D, ALA318D, ALA329D, ALA336E, ALA338D, ALA338E, ALA344E, ALA354E, ALA75E, ALA81E, ARG126D, ARG144D, ARG147D, ARG15E, ARG231D, ARG231E, ARG236E, ARG255D, ARG276D, ARG283D, ARG296D, ARG325D, ARG325E, ARG350E, ARG392E, ARG82E, ASN128D, ASN131D, ASN138D, ASN140D, ASN143D, ASN156E, ASN183E, ASN239E, ASN250D, ASN250E, ASN26E, ASN271D, ASN284D, ASN299D, ASN345E, ASN35D, ASN366E, ASN72E, ASN83E, ASP130D, ASP13D, ASP13E, ASP16E, ASP174E, ASP228D, ASP29D, ASP29E, ASP2D, ASP337E, ASP369E, ASP74E, ASP86E, ASP93E, CYS197D, CYS331D, GLN142D, GLN146D, GLN170E, GLN189E, GLN32D, GLN33D, GLN351E, GLN36D, GLU134D, GLU137D, GLU187D, GLU187E, GLU20E, GLU230D, GLU230E, GLU315E, GLU327D, GLU327E, GLU332D, GLU340E, GLU352E, GLU79E, GLY149D, GLY185E, GLY21E, GLY243E, GLY278D, GLY321D, GLY364E, HIS153D, HIS153E, HIS173E, HIS316D, HIS317D, HIS317E, ILE127D, ILE136D, ILE18E, ILE223D, ILE238E, ILE253D, ILE270D, ILE280D, ILE281D, ILE31D, ILE326D, ILE371E, ILE39D, ILE85E, LEU122D, LEU141D, LEU176E, LEU182E, LEU225D, LEU226D, LEU23E, LEU254D, LEU294D, LEU307D, LEU30D, LEU30E, LEU322D, LEU343E, LEU395E, LEU71E, LEU73E, LYS125D, LYS12E, LYS154D, LYS154E, LYS17D, LYS17E, LYS397E, LYS9D, LYS9E, MET295D, MET300D, MET342E, MET365E, MET37D, MET394E, MET97E, PHE124D, PHE129D, PHE150D, PHE152D, PHE158E, PHE232D, PHE232E, PHE234D, PHE234E, PHE249E, PHE277D, PHE308D, PHE314E, PHE34D, PRO155D, PRO155E, PRO159E, PRO171E, PRO227D, PRO235D, PRO235E, PRO251D, PRO251E, PRO256D, PRO297D, PRO298D, PRO302D, PRO313E, PRO362E, PRO363E, SER132D, SER133D, SER161E, SER186E, SER233D, SER233E, SER240E, SER25E, SER28D, SER28E, SER328D, SER339D, SER339E, SER348E, SER393E, SER6D, THR148D, THR151D, THR219D, THR220D, THR222D, THR224D, THR22E, THR245E, THR246E, THR272D, THR279D, THR301D, THR319D, THR323D, THR341E, THR347E, THR368E, THR40D, TRP139D, TRP247E, TRP367E, TYR135D, TYR160E, TYR195E, TYR248E, TYR24E, TYR273D, TYR353E, TYR5D, VAL19E, VAL237E, VAL252D, VAL27E, VAL304D, VAL320D, VAL330D, VAL346E, VAL349E, VAL396E, VAL3D, VAL78E, VAL89E
• D-L: ALA75D, ALA75L, ARG82D, ASN76D, ASN76L, ASN83L, ASP74D, ASP74L, GLU20D, GLU20L, GLU79D, GLU79L, LEU70L, LEU73D, THR69D, THR80D, THR80L, TYR77D, TYR77L, VAL78D, VAL78L
• D-N: ARG106N, ARG117N, ARG57D, ASN83D, GLU352D, GLU79D, GLY121N, LEU122N, LYS123N, LYS125N, SER120N, THR80D, THR84D
• F-G: ALA14G, ALA162G, ALA172G, ALA184G, ALA221F, ALA229F, ALA229G, ALA244G, ALA275F, ALA282F, ALA303F, ALA305F, ALA306F, ALA318F, ALA329F, ALA336G, ALA338F, ALA338G, ALA344G, ALA354G, ALA75G, ALA81G, ARG126F, ARG144F, ARG145F, ARG147F, ARG15G, ARG231F, ARG231G, ARG236G, ARG255F, ARG276F, ARG283F, ARG296F, ARG325F, ARG325G, ARG350G, ARG392G, ARG82G, ASN128F, ASN131F, ASN138F, ASN140F, ASN143F, ASN156G, ASN183G, ASN239G, ASN250F, ASN250G, ASN26G, ASN271F, ASN284F, ASN299F, ASN345G, ASN35F, ASN366G, ASN72G, ASN83G, ASP130F, ASP13F, ASP13G, ASP16G, ASP174G, ASP228F, ASP29F, ASP29G, ASP2F, ASP337G, ASP369G, ASP74G, ASP86G, ASP93G, CYS197F, CYS331F, GLN146F, GLN170G, GLN189G, GLN32F, GLN33F, GLN351G, GLN36F, GLU134F, GLU137F, GLU187F, GLU187G, GLU20G, GLU230F, GLU230G, GLU315G, GLU327F, GLU327G, GLU332F, GLU340G, GLU352G, GLU79G, GLY149F, GLY185G, GLY21G, GLY243G, GLY278F, GLY321F, GLY364G, HIS153F, HIS153G, HIS173G, HIS316F, HIS317F, HIS317G, ILE127F, ILE136F, ILE157G, ILE18G, ILE223F, ILE238G, ILE253F, ILE270F, ILE280F, ILE281F, ILE31F, ILE326F, ILE371G, ILE39F, ILE85G, LEU122F, LEU141F, LEU176G, LEU182G, LEU225F, LEU226F, LEU23G, LEU254F, LEU294F, LEU307F, LEU30F, LEU30G, LEU322F, LEU343G, LEU395G, LEU71G, LEU73G, LYS125F, LYS12G, LYS154F, LYS154G, LYS17F, LYS17G, LYS397G, LYS9F, LYS9G, MET295F, MET300F, MET342G, MET365G, MET37F, MET394G, MET97G, PHE124F, PHE129F, PHE150F, PHE152F, PHE158G, PHE232F, PHE232G, PHE234F, PHE234G, PHE249G, PHE277F, PHE308F, PHE314G, PHE34F, PRO155F, PRO155G, PRO159G, PRO171G, PRO227F, PRO235F, PRO235G, PRO251F, PRO251G, PRO256F, PRO297F, PRO298F, PRO302F, PRO313G, PRO362G, PRO363G, SER132F, SER133F, SER161G, SER186F, SER186G, SER233F, SER233G, SER240G, SER25G, SER28F, SER28G, SER328F, SER339F, SER339G, SER348G, SER393G, SER6F, THR148F, THR151F, THR219F, THR220F, THR222F, THR224F, THR22G, THR245G, THR246G, THR272F, THR279F, THR301F, THR319F, THR323F, THR341G, THR347G, THR368G, THR40F, TRP139F, TRP247G, TRP367G, TYR135F, TYR160G, TYR195G, TYR248G, TYR24G, TYR273F, TYR353G, TYR5F, VAL19G, VAL237G, VAL252F, VAL27G, VAL304F, VAL320F, VAL330F, VAL346G, VAL349G, VAL396G, VAL3F, VAL78G, VAL89G
• F-H: ALA14F, ALA162F, ALA172F, ALA184F, ALA221H, ALA229F, ALA229H, ALA244F, ALA275H, ALA282H, ALA303H, ALA305H, ALA306H, ALA318H, ALA329H, ALA336F, ALA338F, ALA338H, ALA344F, ALA354F, ALA75F, ARG126H, ARG144H, ARG147H, ARG15F, ARG231F, ARG231H, ARG236F, ARG255H, ARG276H, ARG283H, ARG296H, ARG325F, ARG325H, ARG350F, ARG392F, ARG82F, ASN128H, ASN131H, ASN138H, ASN140H, ASN143H, ASN156F, ASN183F, ASN239F, ASN250F, ASN250H, ASN26F, ASN271H, ASN284H, ASN299H, ASN345F, ASN35H, ASN366F, ASN72F, ASN83F, ASP130H, ASP13F, ASP13H, ASP16F, ASP174F, ASP228H, ASP29F, ASP29H, ASP2H, ASP337F, ASP369F, ASP74F, ASP86F, ASP93F, CYS197H, CYS331H, GLN146H, GLN170F, GLN189F, GLN32H, GLN33H, GLN351F, GLN36H, GLU134H, GLU137H, GLU187F, GLU20F, GLU230F, GLU230H, GLU315F, GLU327F, GLU327H, GLU332H, GLU340F, GLU352F, GLU79F, GLY149H, GLY185F, GLY21F, GLY243F, GLY278H, GLY321H, GLY364F, HIS153F, HIS153H, HIS173F, HIS316H, HIS317F, HIS317H, ILE127H, ILE136H, ILE18F, ILE223H, ILE238F, ILE253H, ILE270H, ILE280H, ILE281H, ILE31H, ILE326H, ILE371F, ILE39H, ILE85F, LEU122H, LEU141H, LEU176F, LEU182F, LEU225H, LEU226H, LEU23F, LEU254H, LEU294H, LEU307H, LEU30F, LEU30H, LEU322H, LEU343F, LEU395F, LEU71F, LEU73F, LYS125H, LYS12F, LYS154F, LYS154H, LYS17F, LYS17H, LYS397F, LYS9F, LYS9H, MET295H, MET300H, MET342F, MET365F, MET37H, MET394F, MET97F, PHE124H, PHE129H, PHE150H, PHE152H, PHE158F, PHE232F, PHE232H, PHE234F, PHE234H, PHE249F, PHE277H, PHE308H, PHE314F, PHE34H, PRO155H, PRO159F, PRO171F, PRO227H, PRO235F, PRO235H, PRO251F, PRO251H, PRO256H, PRO297H, PRO298H, PRO302H, PRO313F, PRO362F, PRO363F, SER132H, SER133H, SER161F, SER186F, SER186H, SER233F, SER233H, SER240F, SER25F, SER28F, SER28H, SER328H, SER339F, SER339H, SER348F, SER393F, SER6H, THR148H, THR151H, THR219H, THR220H, THR222H, THR224H, THR22F, THR245F, THR246F, THR272H, THR279H, THR301H, THR319H, THR323H, THR341F, THR347F, THR368F, THR40H, TRP139H, TRP247F, TRP367F, TYR135H, TYR160F, TYR195F, TYR248F, TYR24F, TYR273H, TYR353F, TYR5H, VAL19F, VAL237F, VAL252H, VAL27F, VAL304H, VAL320H, VAL330H, VAL346F, VAL349F, VAL396F, VAL3H, VAL78F, VAL89F
• G-H: ALA14H, ALA162H, ALA172H, ALA184H, ALA221G, ALA229G, ALA229H, ALA244H, ALA275G, ALA282G, ALA303G, ALA305G, ALA306G, ALA318G, ALA329G, ALA336H, ALA338G, ALA338H, ALA344H, ALA354H, ALA75H, ALA81H, ARG126G, ARG144G, ARG147G, ARG15H, ARG231G, ARG231H, ARG236H, ARG255G, ARG276G, ARG283G, ARG296G, ARG325G, ARG325H, ARG350H, ARG392H, ARG82H, ASN128G, ASN131G, ASN138G, ASN140G, ASN143G, ASN156H, ASN183H, ASN239H, ASN250G, ASN250H, ASN26H, ASN271G, ASN284G, ASN299G, ASN345H, ASN35G, ASN366H, ASN53H, ASN72H, ASN83H, ASP130G, ASP13G, ASP13H, ASP16H, ASP174H, ASP228G, ASP29G, ASP29H, ASP2G, ASP337H, ASP369H, ASP74H, ASP86H, ASP93H, CYS197G, CYS331G, GLN146G, GLN170H, GLN189H, GLN32G, GLN33G, GLN351H, GLN36G, GLU134G, GLU137G, GLU187H, GLU20H, GLU230G, GLU230H, GLU315H, GLU327G, GLU327H, GLU332G, GLU340H, GLU352H, GLU79H, GLY149G, GLY185H, GLY21H, GLY243H, GLY278G, GLY321G, GLY364H, HIS153G, HIS153H, HIS173H, HIS316G, HIS317G, HIS317H, ILE127G, ILE136G, ILE18H, ILE223G, ILE238H, ILE253G, ILE270G, ILE280G, ILE281G, ILE31G, ILE326G, ILE371H, ILE39G, ILE85H, LEU122G, LEU141G, LEU176H, LEU182H, LEU225G, LEU226G, LEU23H, LEU254G, LEU294G, LEU307G, LEU30G, LEU30H, LEU322G, LEU343H, LEU395H, LEU71H, LEU73H, LYS125G, LYS12H, LYS154G, LYS154H, LYS17G, LYS17H, LYS397H, LYS9G, LYS9H, MET295G, MET300G, MET342H, MET365H, MET37G, MET394H, MET97H, PHE124G, PHE129G, PHE150G, PHE152G, PHE158H, PHE232G, PHE232H, PHE234G, PHE234H, PHE249H, PHE277G, PHE308G, PHE314H, PHE34G, PRO155G, PRO155H, PRO159H, PRO171H, PRO227G, PRO235G, PRO235H, PRO251G, PRO251H, PRO256G, PRO297G, PRO298G, PRO302G, PRO313H, PRO362H, PRO363H, SER132G, SER133G, SER161H, SER186G, SER186H, SER233G, SER233H, SER240H, SER25G, SER25H, SER28G, SER28H, SER328G, SER339G, SER339H, SER348H, SER393H, SER6G, THR148G, THR151G, THR219G, THR220G, THR222G, THR224G, THR22H, THR245H, THR246H, THR272G, THR279G, THR301G, THR319G, THR323G, THR341H, THR347H, THR368H, THR40G, THR84H, TRP139G, TRP247H, TRP367H, TYR135G, TYR160H, TYR195H, TYR248H, TYR24H, TYR273G, TYR353H, TYR5G, VAL19H, VAL237H, VAL252G, VAL27H, VAL304G, VAL320G, VAL330G, VAL346H, VAL349H, VAL396H, VAL3G, VAL78H, VAL89H
• G-I: ALA110G, ALA110I, ARG106G, ARG106I, ARG117G, ARG144G, ARG144I, ARG145G, ARG145I, ARG147G, ARG147I, ARG215G, ARG215I, ARG216G, ARG216I, ARG283G, ARG283I, ARG378G, ARG378I, ASN107G, ASN107I, ASN140G, ASN140I, ASN143G, ASN143I, ASN266G, ASN266I, ASN284G, ASN284I, ASN373G, ASN373I, ASN381I, ASP286G, ASP286I, ASP380G, ASP380I, GLN105G, GLN105I, GLN142G, GLN142I, GLN146G, GLN146I, GLN213G, GLN213I, GLN268G, GLN268I, GLN383G, GLN383I, GLU332G, GLU332I, GLU379G, GLU379I, GLY108G, GLY267G, GLY267I, GLY358G, GLY358I, ILE109G, ILE109I, ILE270G, ILE270I, LEU141G, LEU141I, LEU265G, LEU265I, PHE361G, PHE361I, PRO111G, PRO111I, PRO359G, PRO359I, PRO362G, PRO362I, PRO363G, PRO363I, PRO376G, PRO376I, SER104I, SER333G, SER333I, SER375G, SER375I, SER377G, SER377I, THR148G, THR148I, THR219G, THR219I, TRP139G, TRP139I, VAL217G, VAL217I, VAL357G, VAL357I, VAL360G, VAL360I
• G-J: ALA81J, ARG106G, ARG117G, ARG392J, ARG57J, ARG82J, ASN107G, ASN76J, ASN83J, ASN94J, ASP114G, ASP86J, ASP90J, ASP93J, GLN105G, GLN112G, GLU352J, GLU79J, GLY121G, LEU119G, LEU122G, LYS123G, LYS125G, LYS397J, MET97J, PHE124G, PHE63J, PRO55J, SER104G, SER120G, THR80J, THR84J, TRP59J, TYR353J, TYR87J, VAL396J
• H-I: ALA81H, ARG106I, ARG117I, ARG57H, ARG82H, ASN53H, ASN83H, ASN94H, ASP114I, ASP86H, ASP90H, GLN105I, GLN112I, GLU352H, GLU79H, GLY121I, LEU122I, LYS123I, LYS125I, PHE124I, PHE63H, SER120I, THR80H, THR84H, TRP59H, TYR353H
• H-J: ALA75H, ALA75J, ARG82H, ASN76H, ASN76J, ASN83H, ASN83J, ASP74H, ASP74J, GLU20H, GLU20J, GLU79H, GLU79J, LEU70H, LEU70J, LEU73H, LEU73J, THR80H, THR80J, TYR77H, TYR77J, VAL78H, VAL78J
• I-J: ALA14J, ALA162J, ALA172J, ALA184J, ALA221I, ALA229I, ALA229J, ALA244J, ALA275I, ALA282I, ALA303I, ALA305I, ALA306I, ALA318I, ALA329I, ALA336J, ALA338I, ALA338J, ALA344J, ALA354J, ALA75J, ARG126I, ARG144I, ARG147I, ARG15J, ARG231I, ARG231J, ARG236J, ARG255I, ARG276I, ARG283I, ARG296I, ARG325I, ARG325J, ARG350J, ARG392J, ARG82J, ASN128I, ASN131I, ASN138I, ASN140I, ASN143I, ASN156J, ASN183J, ASN239J, ASN250I, ASN250J, ASN26I, ASN26J, ASN271I, ASN284I, ASN299I, ASN345J, ASN35I, ASN366J, ASN72J, ASN83J, ASP130I, ASP13I, ASP13J, ASP16J, ASP174J, ASP228I, ASP29I, ASP29J, ASP2I, ASP337J, ASP369J, ASP86J, ASP93J, CYS197I, CYS331I, GLN146I, GLN170J, GLN189J, GLN32I, GLN33I, GLN351J, GLN36I, GLU134I, GLU137I, GLU187I, GLU187J, GLU20J, GLU230I, GLU230J, GLU315J, GLU327I, GLU327J, GLU332I, GLU340J, GLU352J, GLU79J, GLY149I, GLY185J, GLY21J, GLY243J, GLY278I, GLY321I, GLY364J, HIS153I, HIS153J, HIS173J, HIS316I, HIS317I, HIS317J, ILE127I, ILE136I, ILE18J, ILE223I, ILE238J, ILE253I, ILE270I, ILE280I, ILE281I, ILE31I, ILE326I, ILE371J, ILE39I, ILE85J, LEU122I, LEU141I, LEU176J, LEU182J, LEU225I, LEU226I, LEU23J, LEU254I, LEU294I, LEU307I, LEU30I, LEU30J, LEU322I, LEU343J, LEU395J, LEU71J, LEU73J, LYS125I, LYS12J, LYS154I, LYS154J, LYS17I, LYS17J, LYS397J, LYS9I, LYS9J, MET295I, MET300I, MET342J, MET365J, MET37I, MET394J, MET97J, PHE124I, PHE129I, PHE150I, PHE152I, PHE158J, PHE232I, PHE232J, PHE234I, PHE234J, PHE249J, PHE277I, PHE308I, PHE314J, PHE34I, PRO155I, PRO159J, PRO171J, PRO227I, PRO235I, PRO235J, PRO251I, PRO251J, PRO256I, PRO297I, PRO298I, PRO302I, PRO313J, PRO362J, PRO363J, SER132I, SER133I, SER161J, SER186I, SER186J, SER233I, SER233J, SER240J, SER25I, SER25J, SER28I, SER28J, SER328I, SER339I, SER339J, SER348J, SER393J, SER6I, THR148I, THR151I, THR219I, THR220I, THR222I, THR224I, THR22J, THR245J, THR246J, THR272I, THR279I, THR301I, THR319I, THR323I, THR341J, THR347J, THR368J, THR40I, TRP247J, TRP367J, TYR135I, TYR160J, TYR195J, TYR248J, TYR24J, TYR273I, TYR353J, TYR5I, VAL19J, VAL237J, VAL252I, VAL27I, VAL27J, VAL304I, VAL320I, VAL330I, VAL346J, VAL349J, VAL396J, VAL3I, VAL78J, VAL89J
• I-K: ALA14I, ALA162I, ALA172I, ALA184I, ALA221K, ALA229I, ALA229K, ALA244I, ALA275K, ALA282K, ALA303K, ALA305K, ALA306K, ALA318K, ALA329K, ALA336I, ALA338I, ALA338K, ALA344I, ALA354I, ALA75I, ALA81I, ARG126K, ARG144K, ARG147K, ARG15I, ARG231I, ARG231K, ARG236I, ARG255K, ARG276K, ARG283K, ARG296K, ARG325I, ARG325K, ARG350I, ARG392I, ARG82I, ASN128K, ASN131K, ASN138K, ASN140K, ASN143K, ASN156I, ASN183I, ASN239I, ASN250I, ASN250K, ASN26I, ASN271K, ASN284K, ASN299K, ASN345I, ASN35K, ASN366I, ASN72I, ASN83I, ASP130K, ASP13I, ASP13K, ASP16I, ASP174I, ASP228K, ASP29I, ASP29K, ASP2K, ASP337I, ASP369I, ASP74I, ASP86I, ASP90I, ASP93I, CYS197K, CYS331K, GLN142K, GLN146K, GLN170I, GLN189I, GLN32K, GLN33K, GLN351I, GLN36K, GLU134K, GLU137K, GLU187I, GLU187K, GLU20I, GLU230I, GLU230K, GLU315I, GLU327I, GLU327K, GLU332K, GLU340I, GLU352I, GLU79I, GLY149K, GLY185I, GLY21I, GLY243I, GLY278K, GLY321K, GLY364I, HIS153I, HIS153K, HIS173I, HIS316K, HIS317I, HIS317K, ILE127K, ILE136K, ILE18I, ILE223K, ILE238I, ILE253K, ILE270K, ILE280K, ILE281K, ILE31K, ILE326K, ILE371I, ILE39K, ILE85I, LEU122K, LEU141K, LEU176I, LEU182I, LEU225K, LEU226K, LEU23I, LEU254K, LEU294K, LEU307K, LEU30I, LEU30K, LEU322K, LEU343I, LEU395I, LEU71I, LEU73I, LYS125K, LYS12I, LYS154I, LYS154K, LYS17I, LYS17K, LYS397I, LYS9I, LYS9K, MET295K, MET300K, MET342I, MET365I, MET37K, MET394I, MET97I, PHE124K, PHE129K, PHE150K, PHE152K, PHE158I, PHE232I, PHE232K, PHE234I, PHE234K, PHE249I, PHE277K, PHE308K, PHE314I, PHE34K, PRO155K, PRO159I, PRO171I, PRO227K, PRO235I, PRO235K, PRO251I, PRO251K, PRO256K, PRO297K, PRO298K, PRO302K, PRO313I, PRO362I, PRO363I, SER132K, SER133K, SER161I, SER186I, SER186K, SER233I, SER233K, SER240I, SER25I, SER28I, SER28K, SER328K, SER339I, SER339K, SER348I, SER393I, SER6K, THR148K, THR151K, THR219K, THR220K, THR222K, THR224K, THR22I, THR245I, THR246I, THR272K, THR279K, THR301K, THR319K, THR323K, THR341I, THR347I, THR368I, THR40K, TRP139K, TRP247I, TRP367I, TYR135K, TYR160I, TYR195I, TYR248I, TYR24I, TYR273K, TYR353I, TYR5K, VAL19I, VAL237I, VAL252K, VAL27I, VAL27K, VAL304K, VAL320K, VAL330K, VAL346I, VAL349I, VAL396I, VAL3K, VAL78I, VAL89I
• I-L: ALA81I, ARG106L, ARG117L, ARG57I, ASN107L, ASN76I, ASN83I, ASN94I, ASP86I, ASP90I, GLU352I, GLU79I, GLY121L, LEU122L, LYS123L, LYS125L, MET97I, PRO55I, SER104L, SER120L, THR80I, THR84I, TRP59I, TYR353I, TYR87I
• I-M: ALA75I, ALA75M, ARG82I, ARG82M, ASN76I, ASN76M, ASN83I, ASN83M, ASP74I, ASP74M, GLU20I, GLU20M, GLU79I, GLU79M, LEU70M, LEU73I, LEU73M, THR80I, THR80M, TYR77I, TYR77M, VAL78I, VAL78M
• J-K: ALA14K, ALA162K, ALA172K, ALA184K, ALA221J, ALA229J, ALA229K, ALA244K, ALA275J, ALA282J, ALA303J, ALA305J, ALA306J, ALA318J, ALA329J, ALA336K, ALA338J, ALA338K, ALA344K, ALA354K, ALA75K, ARG126J, ARG144J, ARG147J, ARG15K, ARG231J, ARG231K, ARG236K, ARG255J, ARG276J, ARG283J, ARG296J, ARG325J, ARG325K, ARG350K, ARG392K, ARG82K, ASN128J, ASN131J, ASN138J, ASN140J, ASN143J, ASN156K, ASN183K, ASN239K, ASN250J, ASN250K, ASN26K, ASN271J, ASN284J, ASN299J, ASN345K, ASN35J, ASN366K, ASN72K, ASN83K, ASP130J, ASP13J, ASP13K, ASP16K, ASP174K, ASP228J, ASP29J, ASP29K, ASP2J, ASP337K, ASP369K, ASP86K, ASP93K, CYS197J, CYS331J, GLN142J, GLN146J, GLN170K, GLN189K, GLN32J, GLN33J, GLN351K, GLN36J, GLU134J, GLU137J, GLU187J, GLU187K, GLU20K, GLU230J, GLU230K, GLU315K, GLU327J, GLU327K, GLU332J, GLU340K, GLU352K, GLU79K, GLY149J, GLY185K, GLY21K, GLY243K, GLY278J, GLY321J, GLY364K, HIS153J, HIS153K, HIS173K, HIS316J, HIS317J, HIS317K, ILE127J, ILE136J, ILE157K, ILE18K, ILE223J, ILE238K, ILE253J, ILE270J, ILE280J, ILE281J, ILE31J, ILE326J, ILE371K, ILE39J, ILE85K, LEU122J, LEU141J, LEU176K, LEU182K, LEU225J, LEU226J, LEU23K, LEU254J, LEU294J, LEU307J, LEU30J, LEU30K, LEU322J, LEU343K, LEU395K, LEU71K, LEU73K, LYS125J, LYS12K, LYS154J, LYS154K, LYS17J, LYS17K, LYS397K, LYS9J, LYS9K, MET295J, MET300J, MET342K, MET365K, MET37J, MET394K, PHE124J, PHE129J, PHE150J, PHE152J, PHE158K, PHE232J, PHE232K, PHE234J, PHE234K, PHE249K, PHE277J, PHE308J, PHE314K, PHE34J, PRO155J, PRO155K, PRO159K, PRO171K, PRO227J, PRO235J, PRO235K, PRO251J, PRO251K, PRO256J, PRO297J, PRO298J, PRO302J, PRO313K, PRO362K, PRO363K, SER132J, SER133J, SER161K, SER186J, SER186K, SER233J, SER233K, SER240K, SER25K, SER28J, SER28K, SER328J, SER339J, SER339K, SER348K, SER393K, SER6J, THR148J, THR151J, THR219J, THR220J, THR222J, THR224J, THR22K, THR245K, THR246K, THR272J, THR279J, THR301J, THR319J, THR323J, THR341K, THR347K, THR368K, THR40J, TRP139J, TRP247K, TRP367K, TYR135J, TYR160K, TYR195K, TYR248K, TYR24K, TYR273J, TYR353K, TYR5J, VAL19K, VAL237K, VAL252J, VAL27K, VAL304J, VAL320J, VAL330J, VAL346K, VAL349K, VAL396K, VAL3J, VAL78K, VAL89K
• K-L: ALA110K, ALA110L, ARG106K, ARG106L, ARG144K, ARG144L, ARG145K, ARG145L, ARG147K, ARG147L, ARG216L, ARG283L, ARG378K, ARG378L, ASN107K, ASN107L, ASN140K, ASN140L, ASN143K, ASN143L, ASN266K, ASN266L, ASN284L, ASN373K, ASN373L, ASP286K, ASP286L, ASP369K, ASP380K, ASP380L, GLN105K, GLN105L, GLN142K, GLN142L, GLN146K, GLN146L, GLN268K, GLN268L, GLN383K, GLN383L, GLU332L, GLU379K, GLU379L, GLY108K, GLY267K, GLY267L, ILE109K, ILE109L, ILE270K, ILE270L, LEU141K, LEU141L, LEU265K, LEU265L, PRO359K, PRO362K, PRO376K, PRO376L, SER375K, SER375L, SER377K, SER377L, THR148L, THR219L, THR372K, TRP139K, TRP139L, TYR374K, VAL217K, VAL217L, VAL360K
• K-M: ALA110K, ALA81M, ARG102K, ARG106K, ARG117K, ARG392M, ARG57M, ARG82M, ASN107K, ASN53M, ASN58M, ASN60M, ASN76M, ASN83M, ASN94M, ASP114K, ASP62M, ASP86M, ASP90M, ASP93M, GLN105K, GLN112K, GLN47K, GLU103K, GLU352M, GLU45K, GLU79M, GLY121K, GLY64M, ILE56M, LEU119K, LEU122K, LEU54M, LYS118K, LYS123K, LYS125K, MET1K, MET97M, PHE124K, PHE63M, PHE91M, PRO111K, PRO359K, PRO55M, SER104K, SER113K, SER120K, THR80M, THR84M, TRP59M, TYR353M, TYR87M, VAL396M, VAL3K, VAL78M, VAL89M
• L-M: ALA14M, ALA162M, ALA172M, ALA184M, ALA221L, ALA229L, ALA229M, ALA244M, ALA275L, ALA282L, ALA303L, ALA305L, ALA306L, ALA318L, ALA329L, ALA336M, ALA338L, ALA338M, ALA344M, ALA354M, ALA75M, ARG126L, ARG144L, ARG147L, ARG15M, ARG231L, ARG231M, ARG236M, ARG255L, ARG276L, ARG283L, ARG296L, ARG325L, ARG325M, ARG350M, ARG392M, ARG82M, ASN128L, ASN131L, ASN138L, ASN140L, ASN143L, ASN156M, ASN183M, ASN239M, ASN250L, ASN250M, ASN26M, ASN271L, ASN284L, ASN299L, ASN345M, ASN35L, ASN366M, ASN72M, ASN83M, ASP130L, ASP13L, ASP13M, ASP16M, ASP174M, ASP228L, ASP29L, ASP29M, ASP2L, ASP337M, ASP369M, ASP74M, ASP86M, ASP93M, CYS197L, CYS331L, GLN146L, GLN170M, GLN189M, GLN32L, GLN33L, GLN351M, GLN36L, GLU134L, GLU137L, GLU187L, GLU187M, GLU20M, GLU230L, GLU230M, GLU315M, GLU327L, GLU327M, GLU332L, GLU340M, GLU352M, GLU79M, GLY149L, GLY185M, GLY21M, GLY243M, GLY278L, GLY321L, GLY364M, HIS153L, HIS153M, HIS173M, HIS316L, HIS317L, HIS317M, ILE127L, ILE136L, ILE18M, ILE223L, ILE238M, ILE253L, ILE270L, ILE280L, ILE281L, ILE31L, ILE326L, ILE371M, ILE39L, ILE85M, LEU122L, LEU141L, LEU176M, LEU182M, LEU225L, LEU226L, LEU23M, LEU254L, LEU294L, LEU307L, LEU30L, LEU30M, LEU322L, LEU343M, LEU395M, LEU70M, LEU71M, LEU73M, LYS125L, LYS12M, LYS154L, LYS154M, LYS17L, LYS17M, LYS397M, LYS9L, LYS9M, MET295L, MET300L, MET342M, MET365M, MET37L, MET394M, MET97M, PHE124L, PHE129L, PHE150L, PHE152L, PHE158M, PHE232L, PHE232M, PHE234L, PHE234M, PHE249M, PHE277L, PHE308L, PHE314M, PHE34L, PRO155L, PRO159M, PRO171M, PRO227L, PRO235L, PRO235M, PRO251L, PRO251M, PRO256L, PRO297L, PRO298L, PRO302L, PRO313M, PRO362M, PRO363M, SER132L, SER133L, SER161M, SER186L, SER186M, SER233L, SER233M, SER240M, SER25M, SER28L, SER28M, SER328L, SER339L, SER339M, SER348M, SER393M, SER6L, THR148L, THR151L, THR219L, THR220L, THR222L, THR224L, THR22M, THR245M, THR246M, THR272L, THR279L, THR301L, THR319L, THR323L, THR341M, THR347M, THR368M, THR40L, TRP139L, TRP247M, TRP367M, TYR135L, TYR160M, TYR195M, TYR248M, TYR24M, TYR273L, TYR353M, TYR5L, VAL19M, VAL237M, VAL252L, VAL27M, VAL304L, VAL320L, VAL330L, VAL346M, VAL349M, VAL396M, VAL3L, VAL78M, VAL89M
• L-N: ALA14L, ALA162L, ALA172L, ALA184L, ALA221N, ALA229L, ALA229N, ALA244L, ALA275N, ALA282N, ALA303N, ALA305N, ALA306N, ALA318N, ALA336L, ALA338L, ALA344L, ALA354L, ALA75L, ALA81L, ARG126N, ARG144N, ARG147N, ARG15L, ARG231L, ARG231N, ARG236L, ARG255N, ARG276N, ARG283N, ARG296N, ARG350L, ARG392L, ARG82L, ASN128N, ASN131N, ASN138N, ASN140N, ASN143N, ASN156L, ASN183L, ASN239L, ASN250L, ASN250N, ASN26L, ASN271N, ASN284N, ASN299N, ASN345L, ASN35N, ASN366L, ASN72L, ASN83L, ASP130N, ASP13L, ASP13N, ASP16L, ASP174L, ASP228N, ASP29L, ASP29N, ASP2N, ASP337L, ASP369L, ASP74L, ASP86L, ASP93L, CYS197N, GLN146N, GLN170L, GLN189L, GLN32N, GLN33N, GLN351L, GLN36N, GLU134N, GLU137N, GLU187L, GLU187N, GLU20L, GLU230L, GLU230N, GLU315L, GLU327L, GLU327N, GLU340L, GLU352L, GLU79L, GLY149N, GLY185L, GLY21L, GLY243L, GLY278N, GLY364L, HIS153L, HIS153N, HIS173L, HIS316N, HIS317L, HIS317N, ILE127N, ILE136N, ILE18L, ILE223N, ILE238L, ILE253N, ILE270N, ILE280N, ILE281N, ILE31N, ILE371L, ILE39N, ILE85L, LEU122N, LEU141N, LEU176L, LEU182L, LEU225N, LEU226N, LEU23L, LEU254N, LEU294N, LEU307N, LEU30L, LEU30N, LEU343L, LEU395L, LEU70L, LEU71L, LEU73L, LYS125N, LYS12L, LYS154L, LYS154N, LYS17L, LYS17N, LYS397L, LYS9L, LYS9N, MET295N, MET300N, MET342L, MET365L, MET37N, MET394L, MET97L, PHE124N, PHE129N, PHE150N, PHE152N, PHE158L, PHE232L, PHE232N, PHE234L, PHE234N, PHE249L, PHE277N, PHE308N, PHE314L, PHE34N, PRO155N, PRO159L, PRO171L, PRO227N, PRO235L, PRO235N, PRO251L, PRO251N, PRO256N, PRO297N, PRO298N, PRO302N, PRO313L, PRO362L, PRO363L, SER132N, SER133N, SER161L, SER186L, SER186N, SER233L, SER233N, SER240L, SER25L, SER28L, SER28N, SER339L, SER348L, SER393L, SER6N, THR148N, THR151N, THR219N, THR220N, THR222N, THR224N, THR22L, THR245L, THR246L, THR272N, THR279N, THR301N, THR319N, THR341L, THR347L, THR368L, THR40N, TRP139N, TRP247L, TRP367L, TYR135N, TYR160L, TYR195L, TYR248L, TYR24L, TYR273N, TYR353L, TYR5N, VAL19L, VAL237L, VAL252N, VAL27L, VAL304N, VAL346L, VAL349L, VAL396L, VAL3N, VAL78L, VAL89L
• M-N: ALA14N, ALA162N, ALA172N, ALA184N, ALA229M, ALA229N, ALA244N, ALA275M, ALA303M, ALA305M, ALA306M, ALA318M, ALA338M, ALA75N, ARG126M, ARG144M, ARG145M, ARG147M, ARG15N, ARG231M, ARG231N, ARG236N, ARG255M, ARG276M, ARG283M, ARG296M, ARG325M, ARG82N, ASN128M, ASN131M, ASN138M, ASN140M, ASN143M, ASN156N, ASN183N, ASN239N, ASN250M, ASN250N, ASN26N, ASN299M, ASN35M, ASN72N, ASN83N, ASP130M, ASP13M, ASP13N, ASP16N, ASP174N, ASP228M, ASP29M, ASP29N, ASP2M, ASP337N, ASP74N, ASP86N, ASP93N, CYS197M, GLN146M, GLN170N, GLN189N, GLN32M, GLN33M, GLN36M, GLU134M, GLU137M, GLU187M, GLU187N, GLU20N, GLU230M, GLU230N, GLU315N, GLU327M, GLU352N, GLU79N, GLY185N, GLY21N, GLY243N, GLY278M, GLY321M, HIS153M, HIS153N, HIS173N, HIS316M, HIS317M, HIS317N, ILE127M, ILE136M, ILE157N, ILE18N, ILE223M, ILE238N, ILE253M, ILE280M, ILE281M, ILE31M, ILE326M, ILE39M, ILE85N, LEU122M, LEU141M, LEU176N, LEU182N, LEU225M, LEU226M, LEU23N, LEU254M, LEU294M, LEU307M, LEU30M, LEU30N, LEU322M, LEU71N, LEU73N, LYS125M, LYS12N, LYS154M, LYS154N, LYS17M, LYS17N, LYS397N, LYS9M, LYS9N, MET295M, MET300M, MET37M, MET97N, PHE124M, PHE129M, PHE158N, PHE232M, PHE232N, PHE234M, PHE234N, PHE249N, PHE277M, PHE308M, PHE314N, PHE34M, PRO155N, PRO159N, PRO171N, PRO227M, PRO235M, PRO235N, PRO251M, PRO251N, PRO256M, PRO297M, PRO298M, PRO302M, PRO313N, SER132M, SER133M, SER161N, SER186M, SER186N, SER233M, SER233N, SER240N, SER25M, SER25N, SER28M, SER28N, SER328M, SER339M, SER6M, THR148M, THR222M, THR224M, THR22N, THR245N, THR246N, THR279M, THR301M, THR319M, THR323M, THR40M, TRP247N, TYR160N, TYR195N, TYR248N, TYR24N, TYR5M, VAL19N, VAL237N, VAL252M, VAL27N, VAL304M, VAL320M, VAL3M, VAL78N, VAL89N
• M-O: ARG106M, ARG117M, ASP90O, GLU352O, GLU79O, LYS125M
• N-O: ASP74N, ASP74O, GLU20N, GLU20O, GLU79N, GLU79O