3KYM

crystal structure of li33 igg2 di-fab

• Total interactions analyzed: 120
• Total true interactions: 37
• Strongest Interaction:
  • Chains: I-J
  • Int. Res.: 190
  • Norm. En. per Res.: -2.5982
• Hub Node: D(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-33.4136	-3.4083	-422.138	-458.9599	187	22	14	17332	2	19	23
A-F	0.0	0.0	-43.7394	-43.7394	26	0	0	1800	0	1	3
A-O	-2.1725	-9.0347	-52.6045	-63.8117	42	17	0	2368	1	13	10
A-P	0.0	0.0	-1.6948	-1.6948	7	0	0	102	0	2	0
B-E	-16.3575	0.0	-43.6063	-59.9638	28	5	0	1679	0	1	2
B-F	-5.0826	10.7122	-99.3139	-93.6843	45	1	0	4192	0	11	8
B-O	0.0	0.0	-0.0014	-0.0014	2	0	0	1	0	0	0
B-P	0.0	0.0	-7.3968	-7.3968	12	0	0	533	0	2	3
C-D	-8.1401	3.8391	-444.217	-448.5179	180	16	15	17572	1	22	22
C-L	-7.7461	11.9538	-58.1673	-53.9597	42	2	0	2601	0	10	9
C-M	0.0	0.0	-0.0184	-0.0184	5	0	0	16	0	2	4
C-N	0.0	0.0	-30.9441	-30.9441	31	2	0	987	0	3	3
D-K	-13.6435	43.8347	-89.4044	-59.2131	42	6	0	3344	0	9	12
D-L	0.0	12.4406	-12.6168	-0.1762	26	0	0	884	0	8	8
D-M	-2.9019	0.0	-34.3283	-37.2302	35	8	0	2023	0	0	0
D-O	0.0	-1.5253	-29.4134	-30.9387	27	3	0	1709	0	5	5
D-P	-23.7748	0.7979	-121.232	-144.2088	76	20	1	6336	0	14	16
E-F	-6.9822	10.6862	-433.806	-430.1021	184	25	12	17721	2	18	23
E-K	0.0	0.0	-0.4042	-0.4042	7	0	0	114	0	2	4
E-L	-3.0248	0.0	-20.3014	-23.3262	20	0	0	868	0	2	1
F-I	-13.2689	-2.045	-12.9047	-28.2186	19	11	0	951	0	3	3
F-J	-18.9225	-20.2399	-120.299	-159.4614	83	3	0	5619	2	11	15
F-K	0.0	0.0	-46.1782	-46.1782	41	0	0	2069	0	0	0
G-H	-7.0128	-22.2518	-415.534	-444.7987	188	17	14	17056	2	15	22
G-O	0.0	0.0	-0.0013	-0.0013	5	0	0	4	0	0	0
H-L	0.0	0.0	-0.0011	-0.0011	3	0	0	3	0	0	0
H-M	-5.9282	-3.2048	67.0037	57.8708	19	17	0	1100	0	3	3
H-N	-28.1765	1.6241	-148.78	-175.3324	86	16	2	6405	0	11	15
H-P	-3.5718	0.0	-30.8959	-34.4677	33	0	0	1777	0	4	2
I-J	-38.5642	-5.2575	-449.834	-493.6557	190	23	15	18375	2	21	22
J-L	0.0	0.0	-0.0458	-0.0458	5	0	0	24	0	2	0
K-L	-26.5646	0.7579	-422.671	-448.4777	175	20	14	16978	0	22	22
K-M	0.0	4.2782	-17.4385	-13.1603	29	1	1	1260	0	10	12
L-P	0.0	0.0	-0.0003	-0.0003	2	0	0	1	0	0	0
M-N	-10.7532	5.9688	-425.274	-430.0584	178	30	14	17354	2	19	22
N-P	0.0	0.0	-1.63	-1.63	12	0	0	201	0	2	1
O-P	-28.7374	10.6504	-436.95	-455.037	183	25	14	18075	2	23	23

Interface residues

• A-B: ALA130A, ALA131B, ALA142B, ALA143B, ALA174B, ALA34A, ALA43A, ALA55A, ALA61B, ALA97B, ARG111B, ARG135B, ARG142A, ARG211A, ARG219B, ARG38B, ARG45A, ASN102B, ASN137A, ASN138A, ASN158A, ASN210A, ASN53A, ASP103B, ASP107B, ASP122A, ASP150B, ASP167A, ASP170A, ASP1A, ASP1A5, ASP50A, ASP62B, ASP92A, CB9.7672035.10231, CYS133B, CYS134A, CYS146B, CYS88A, CYS96B, GLN124A, GLN160A, GLN177B, GLN37A, GLN38A, GLN39B, GLN42A, GLN89A, GLN90A, GLU123A, GLU139B, GLU161A, GLU165A, GLU46B, GLU6B, GLU99B, GLY100A, GLY100B, GLY101A, GLY110B, GLY112B, GLY145B, GLY157A, GLY168B, GLY180B, GLY212A, GLY41A, GLY42B, GLY44B, GLY99A, HIS101B, HIS170B, ILE117A, ILE48A, LEU108B, LEU125A, LEU130B, LEU135A, LEU136A, LEU144B, LEU147B, LEU175A, LEU176B, LEU179A, LEU181A, LEU181B, LEU184B, LEU33A, LEU45B, LEU46A, LEU47A, LEU4B, LEU96A, LYS126A, LYS149B, LYS169A, LYS207A, LYS215B, LYS220B, LYS43B, LYS59B, LYS65B, LYS93A, PHE106B, PHE116A, PHE118A, PHE128B, PHE139A, PHE172B, PHE209A, PHE35B, PHE98A, PRO119A, PRO120A, PRO129B, PRO132B, PRO173B, PRO191B, PRO44A, PRO95A, SER114A, SER121A, SER126B, SER127A, SER131A, SER134B, SER140B, SER159A, SER162A, SER167B, SER168A, SER174A, SER176A, SER177A, SER178B, SER179B, SER183B, SER185B, SER186B, SER208A, SER49B, THR129A, THR137B, THR141B, THR164A, THR171B, THR172A, THR178A, THR180A, THR189B, THR56A, THR58B, THR93B, THR97A, TRP104B, TRP109B, TRP35A, TRP36B, TRP47B, TRP50B, TRP94A, TYR105B, TYR173A, TYR182B, TYR32A, TYR36A, TYR49A, TYR60B, TYR86A, TYR87A, TYR91A, TYR95B, VAL115A, VAL127B, VAL132A, VAL133A, VAL148B, VAL163A, VAL169B, VAL175B, VAL187B, VAL188B, VAL190B, VAL217B, VAL37B, VAL48B, VAL85A
• A-F: ARG72F, ASN53A, ASN74F, ASP50A, ASP92A, GLN90A, GLY52F, GLY55F, GLY56F, ILE31F, ILE57F, LYS93A, PHE29F, PRO53F, SER30A, SER30F, SER31A, SER54F, SER75F, THR28F, TRP94A, TYR32A, TYR32F, TYR49A, TYR91A, VAL29A
• A-O: ALA60A, ALA60O, ARG18A, ARG45O, ARG61A, ARG61O, ASP82A, ASP82O, GLN37O, GLN42O, GLN79A, GLN79O, GLU17A, GLU81A, GLU81O, GLY16A, GLY16O, GLY57O, ILE106A, ILE58O, LEU78A, LEU78O, LYS169A, LYS169O, LYS39A, LYS39O, PHE62O, PHE83A, PHE83O, PRO15A, PRO15O, PRO59A, PRO59O, SER14A, SER168A, SER168O, SER76A, SER76O, SER77A, SER77O, SER80A, SER80O
• A-P: ARG111P, ARG45A, GLN3P, GLU1P, GLY57A, ILE58A, THR56A
• B-E: ARG72B, ASN53E, ASN74B, ASP50E, ASP92E, GLY52B, GLY55B, GLY56B, ILE31B, ILE57B, LEU96E, LYS93E, PHE29B, PRO53B, PRO95E, SER28E, SER30B, SER30E, SER31E, SER54B, SER75B, THR28B, TRP94E, TYR32B, TYR32E, TYR49E, TYR91E, VAL29E
• B-F: ARG98B, ARG98F, ASN102B, ASN102F, ASP103B, ASP103F, ASP107B, ASP107F, GLU99B, GLU99F, GLY100B, GLY100F, GLY52B, GLY52F, GLY55B, GLY55F, GLY56B, HIS101B, HIS101F, ILE31B, ILE31F, ILE51B, ILE57B, ILE57F, LYS59B, LYS59F, PHE35B, PRO33B, PRO33F, PRO53B, PRO53F, SER30B, SER30F, SER54B, SER54F, THR58B, THR58F, TRP104B, TRP104F, TRP50B, TRP50F, TYR105B, TYR105F, TYR32B, TYR32F
• B-O: GLU1B, THR56O
• B-P: GLN3P, GLU1B, GLU1P, GLY26B, GLY26P, LEU108B, PHE27B, PHE27P, SER25P, THR28P, VAL2B, VAL2P
• C-D: ALA130C, ALA131D, ALA142D, ALA143D, ALA174D, ALA34C, ALA43C, ALA51C, ALA55C, ALA61D, ALA97D, ARG111D, ARG135D, ARG142C, ARG211C, ARG38D, ARG45C, ARG98D, ASN102D, ASN137C, ASN138C, ASN210C, ASP103D, ASP107D, ASP122C, ASP150D, ASP167C, ASP170C, ASP1C, ASP50C, ASP62D, ASP92C, CYS133D, CYS134C, CYS146D, CYS88C, CYS96D, GLN124C, GLN160C, GLN177D, GLN37C, GLN38C, GLN39D, GLN42C, GLN89C, GLN90C, GLU123C, GLU139D, GLU161C, GLU165C, GLU46D, GLU6D, GLU99D, GLY100C, GLY100D, GLY101C, GLY110D, GLY112D, GLY145D, GLY168D, GLY180D, GLY41C, GLY42D, GLY44D, GLY99C, HIS101D, HIS170D, ILE117C, ILE48C, ILE58C, LEU108D, LEU125C, LEU130D, LEU135C, LEU136C, LEU144D, LEU147D, LEU175C, LEU176D, LEU179C, LEU181C, LEU181D, LEU184D, LEU33C, LEU45D, LEU46C, LEU47C, LEU96C, LYS126C, LYS149D, LYS169C, LYS207C, LYS215D, LYS43D, LYS59D, LYS65D, LYS93C, PHE106D, PHE116C, PHE118C, PHE128D, PHE139C, PHE172D, PHE209C, PHE35D, PHE98C, PRO119C, PRO120C, PRO129D, PRO132D, PRO173D, PRO191D, PRO44C, PRO95C, SER114C, SER121C, SER126D, SER127C, SER131C, SER134D, SER140D, SER159C, SER162C, SER167D, SER174C, SER176C, SER177C, SER178D, SER179D, SER183D, SER185D, SER186D, SER208C, SER49D, THR129C, THR137D, THR141D, THR164C, THR166D, THR171D, THR172C, THR178C, THR180C, THR189D, THR56C, THR93D, THR97C, TRP104D, TRP109D, TRP35C, TRP36D, TRP47D, TRP50D, TRP94C, TYR105D, TYR173C, TYR182D, TYR32C, TYR36C, TYR49C, TYR60D, TYR86C, TYR87C, TYR91C, TYR95D, VAL115C, VAL127D, VAL132C, VAL133C, VAL163C, VAL169D, VAL175D, VAL187D, VAL188D, VAL190D, VAL213D, VAL217D, VAL37D, VAL48D, VAL85C
• C-L: ARG211C, ARG219L, ASN161L, ASN194L, ASN203L, ASN210C, ASP122C, ASP214L, CYS202L, GLN124C, GLN198L, GLU123C, GLU187C, GLU213C, GLU218L, GLY196L, GLY212C, LEU125C, LEU144L, LYS126C, LYS183C, LYS190C, LYS215L, PHE195L, PHE209C, PRO119C, PRO120C, SER121C, SER127C, SER136L, SER162L, SER192L, SER193L, THR137L, THR197L, THR199L, THR201L, THR216L, TYR186C, TYR192C, TYR200L, VAL217L
• C-M: ARG108C, GLU81M, LYS169C, LYS169M, THR109C
• C-N: ALA164N, ALA60C, ARG108C, ARG18C, ASN161N, ASN203N, ASP205N, GLN79C, GLU17C, GLY163N, GLY16C, ILE106C, LEU13C, LEU165N, LEU78C, LYS107C, LYS207N, LYS212N, PHE83C, PRO15C, SER14C, SER159N, SER162N, SER167N, SER76C, SER77C, SER80C, THR109C, THR157N, THR166N, TRP160N
• D-K: ARG135D, ARG211K, ARG219D, ASN161D, ASN194D, ASN210K, ASP122K, ASP214D, GLN124K, GLN198D, GLU123K, GLU187K, GLU218D, GLY196D, GLY212K, HIS189K, LEU125K, LYS126K, LYS188K, LYS190K, LYS207K, LYS215D, LYS220D, PHE195D, PHE209K, PRO120K, PRO191D, SER121K, SER134D, SER136D, SER138D, SER192D, SER193D, SER208K, THR137D, THR197D, THR199D, THR201D, THR216D, TYR186K, TYR200D, VAL217D
• D-L: ALA131D, ALA131L, ARG135D, ARG135L, ARG219D, ARG219L, ASP214D, ASP214L, CYS133D, CYS133L, GLU218D, GLU218L, LYS215D, LYS215L, LYS220D, PHE128D, PHE128L, PRO129D, PRO129L, PRO132D, PRO132L, SER134D, SER136D, THR216D, THR216L, VAL217L
• D-M: ALA164D, ALA60M, ARG45M, ARG54M, ARG61M, ASN161D, ASN194D, ASP82M, GLN198D, GLN79M, GLU17M, GLU81M, GLY16M, GLY196D, GLY57M, ILE58M, ILE75M, LEU165D, LEU78M, LYS39M, PHE195D, PHE62M, PRO15M, PRO191D, PRO59M, SER162D, SER167D, SER193D, SER76M, SER77M, SER80M, THR197D, THR199D, TYR200D, VAL190D
• D-O: ALA23D, ALA24D, ALA51O, ARG19D, ARG72D, ASN77D, ASP50O, ASP73D, ASP92O, CYS22D, GLU6D, LEU33O, LEU5D, LEU79D, LYS76D, LYS93O, SER21D, SER30O, SER31O, SER71D, SER75D, SER7D, THR78D, TYR32O, TYR80D, TYR91O, VAL29O
• D-P: ARG111D, ARG19D, ARG19P, ARG72P, ASN102P, ASN210D, ASN74P, ASN77P, ASP103P, ASP73P, CYS22D, GLN13D, GLN82D, GLN82P, GLU154D, GLU6D, GLY10D, GLY124D, GLY16D, GLY52P, GLY55P, GLY56P, GLY8D, GLY9D, HIS101P, HIS206D, ILE31P, ILE51P, ILE57P, ILE70P, LEU114D, LEU11D, LEU18D, LEU20D, LEU79D, LEU79P, LEU81D, LYS123D, LYS207D, LYS212D, LYS59P, LYS76D, LYS76P, MET83D, PHE152D, PHE29P, PRO153D, PRO155D, PRO208D, PRO33P, PRO53P, SER121D, SER17D, SER209D, SER21D, SER21P, SER30P, SER54P, SER71D, SER71P, SER75P, SER7D, THR113D, THR122D, THR211D, THR28P, THR58P, THR69P, THR78D, THR78P, TRP104P, TRP50P, TYR60P, TYR80D, TYR80P, VAL12D
• E-F: ALA130E, ALA131F, ALA142F, ALA143F, ALA174F, ALA34E, ALA43E, ALA55E, ALA61F, ALA97F, ARG111F, ARG135F, ARG142E, ARG211E, ARG38F, ARG45E, ARG98F, ASN102F, ASN137E, ASN138E, ASN158E, ASN210E, ASN53E, ASP103F, ASP107F, ASP122E, ASP150F, ASP167E, ASP170E, ASP1E, ASP50E, ASP62F, ASP92E, CYS133F, CYS134E, CYS146F, CYS88E, CYS96F, GLN124E, GLN160E, GLN177F, GLN37E, GLN38E, GLN39F, GLN3F, GLN42E, GLN89E, GLN90E, GLU123E, GLU139F, GLU161E, GLU165E, GLU46F, GLU6F, GLU99F, GLY100E, GLY100F, GLY101E, GLY110F, GLY112F, GLY128E, GLY145F, GLY168F, GLY41E, GLY42F, GLY44F, GLY99E, HIS101F, HIS170F, ILE117E, ILE48E, LEU108F, LEU125E, LEU130F, LEU135E, LEU136E, LEU144F, LEU147F, LEU175E, LEU176F, LEU179E, LEU181E, LEU184F, LEU33E, LEU45F, LEU46E, LEU47E, LEU4F, LEU5F, LEU96E, LYS126E, LYS149F, LYS169E, LYS207E, LYS215F, LYS43F, LYS59F, LYS93E, PHE106F, PHE116E, PHE118E, PHE128F, PHE139E, PHE172F, PHE195F, PHE209E, PHE35F, PHE98E, PRO119E, PRO120E, PRO129F, PRO132F, PRO173F, PRO191F, PRO40E, PRO44E, PRO95E, SER114E, SER121E, SER126F, SER127E, SER131E, SER134F, SER140F, SER159E, SER162E, SER167F, SER168E, SER174E, SER176E, SER177E, SER178F, SER179F, SER183F, SER185F, SER186F, SER208E, SER31E, SER49F, THR129E, THR137F, THR141F, THR164E, THR171F, THR172E, THR178E, THR180E, THR189F, THR56E, THR58F, THR93F, THR97E, TRP104F, TRP109F, TRP35E, TRP36F, TRP47F, TRP50F, TRP94E, TYR105F, TYR173E, TYR186E, TYR32E, TYR36E, TYR49E, TYR60F, TYR86E, TYR87E, TYR91E, TYR95F, VAL115E, VAL127F, VAL132E, VAL133E, VAL163E, VAL169F, VAL175F, VAL187F, VAL188F, VAL190F, VAL217F, VAL37F, VAL48F, VAL85E
• E-K: ARG108E, GLU81K, LYS169E, LYS169K, SER168K, SER80K, THR109E
• E-L: ALA164L, ARG18E, ARG61E, ASN161L, GLN79E, GLU17E, GLY163L, GLY16E, LEU165L, LEU78E, PRO15E, SER14E, SER159L, SER162L, SER167L, SER76E, SER77E, SER80E, THR166L, TRP160L
• F-I: ARG19F, ARG72F, ASN74F, ASN77F, ASP50I, ASP73F, ASP92I, LYS76F, LYS93I, SER25F, SER28I, SER30I, SER31I, SER75F, THR78F, TYR32I, TYR80F, TYR91I, VAL29I
• F-J: ALA23F, ARG111F, ARG19F, ARG19J, ARG72J, ASN102J, ASN210F, ASN74J, ASN77J, ASN84F, ASP103J, ASP73F, ASP73J, CYS22F, GLN13F, GLN82F, GLN82J, GLU154F, GLU6F, GLU99J, GLY100J, GLY10F, GLY112F, GLY124F, GLY16F, GLY52J, GLY55J, GLY56J, GLY8F, GLY9F, HIS101J, HIS206F, ILE31J, ILE51J, ILE57J, ILE70J, LEU114F, LEU11F, LEU18F, LEU20F, LEU5F, LEU79J, LEU86F, LYS123F, LYS207F, LYS212F, LYS59J, LYS76F, LYS76J, MET83F, PHE152F, PHE27J, PHE29J, PRO153F, PRO155F, PRO208F, PRO33J, PRO53J, SER121F, SER17F, SER209F, SER21F, SER30J, SER54J, SER71J, SER75J, SER7F, THR113F, THR116F, THR122F, THR211F, THR28J, THR58J, THR69J, THR78F, THR78J, TRP104J, TRP50J, TYR105J, TYR32J, TYR80F, TYR80J, VAL12F
• F-K: ALA164F, ALA60K, ARG45K, ARG54K, ARG61K, ASN161F, ASN194F, ASP82K, GLN198F, GLN79K, GLU17K, GLU81K, GLY168F, GLY16K, GLY196F, GLY57K, ILE58K, ILE75K, LEU165F, LEU78K, PHE195F, PHE62K, PRO15K, PRO191F, PRO59K, SER140F, SER162F, SER167F, SER192F, SER193F, SER63K, SER76K, SER77K, SER80K, THR141F, THR166F, THR197F, THR199F, THR56K, TYR200F, VAL190F
• G-H: ALA130G, ALA131H, ALA142H, ALA143H, ALA174H, ALA34G, ALA43G, ALA51G, ALA55G, ALA61H, ALA97H, ARG111H, ARG135H, ARG211G, ARG38H, ARG45G, ARG98H, ASN102H, ASN137G, ASN138G, ASN158G, ASN210G, ASN53G, ASP103H, ASP107H, ASP122G, ASP150H, ASP167G, ASP170G, ASP1G, ASP50G, ASP62H, ASP92G, CYS133H, CYS134G, CYS146H, CYS88G, CYS96H, GLN124G, GLN160G, GLN166G, GLN177H, GLN37G, GLN38G, GLN39H, GLN3H, GLN42G, GLN89G, GLN90G, GLU123G, GLU139H, GLU161G, GLU165G, GLU46H, GLU6H, GLU99H, GLY100G, GLY100H, GLY101G, GLY110H, GLY112H, GLY145H, GLY157G, GLY168H, GLY212G, GLY41G, GLY42H, GLY44H, GLY99G, HIS101H, HIS170H, ILE117G, ILE48G, LEU108H, LEU125G, LEU130H, LEU135G, LEU136G, LEU144H, LEU147H, LEU175G, LEU176H, LEU179G, LEU181G, LEU181H, LEU184H, LEU33G, LEU45H, LEU46G, LEU47G, LEU4H, LEU5H, LEU96G, LYS126G, LYS149H, LYS169G, LYS207G, LYS215H, LYS39G, LYS43H, LYS59H, LYS65H, PHE106H, PHE116G, PHE118G, PHE128H, PHE139G, PHE172H, PHE195H, PHE209G, PHE35H, PHE98G, PRO119G, PRO120G, PRO129H, PRO132H, PRO173H, PRO191H, PRO40G, PRO44G, PRO95G, SER114G, SER121G, SER126H, SER127G, SER131G, SER134H, SER140H, SER159G, SER162G, SER167H, SER168G, SER174G, SER176G, SER177G, SER178H, SER179H, SER183H, SER185H, SER186H, SER208G, SER49H, THR129G, THR137H, THR141H, THR164G, THR171H, THR172G, THR178G, THR180G, THR189H, THR56G, THR93H, THR97G, TRP104H, TRP109H, TRP35G, TRP36H, TRP47H, TRP50H, TRP94G, TYR105H, TYR173G, TYR186G, TYR32G, TYR36G, TYR49G, TYR60H, TYR86G, TYR87G, TYR91G, TYR95H, VAL115G, VAL127H, VAL132G, VAL133G, VAL148H, VAL163G, VAL169H, VAL175H, VAL187H, VAL188H, VAL190H, VAL213H, VAL217H, VAL37H, VAL48H, VAL85G
• G-O: ALA184O, GLN147O, GLN3G, SER156G, SER182O
• H-L: GLY15L, LYS65H, PRO14L
• H-M: ARG19H, ARG72H, ASN74H, ASN77H, ASP50M, ASP73H, ASP92M, ILE2M, LYS76H, LYS93M, SER28M, SER30M, SER31M, SER75H, THR78H, TYR32M, TYR80H, TYR91M, VAL29M
• H-N: ALA23H, ARG111H, ARG19H, ARG19N, ARG72H, ARG72N, ASN102N, ASN210H, ASN74N, ASN77N, ASN84H, ASP103N, ASP73H, ASP73N, CYS22H, GLN13H, GLN82H, GLN82N, GLU154H, GLU6H, GLU99N, GLY100N, GLY10H, GLY124H, GLY15H, GLY16H, GLY52N, GLY55N, GLY56N, GLY8H, GLY9H, HIS101N, HIS206H, ILE31N, ILE51N, ILE57N, ILE70N, LEU11H, LEU18H, LEU20H, LEU5H, LEU79H, LEU79N, LEU81N, LEU86H, LYS123H, LYS207H, LYS212H, LYS59N, LYS76H, LYS76N, MET83H, PHE152H, PHE29N, PRO153H, PRO155H, PRO208H, PRO33N, PRO53N, SER121H, SER17H, SER209H, SER21H, SER30N, SER54N, SER71H, SER71N, SER75N, SER7H, THR113H, THR122H, THR157H, THR211H, THR28N, THR58N, THR69H, THR69N, THR78H, THR78N, TRP104N, TRP50N, TYR105N, TYR32N, TYR80H, TYR80N, VAL12H
• H-P: ALA120H, ALA120P, ALA88H, ALA88P, ARG67H, ARG67P, ARG87H, ARG87P, GLN13H, GLN13P, GLU89H, GLU89P, GLY15H, GLY15P, GLY16H, GLY16P, GLY180P, LEU86H, LEU86P, PRO14H, PRO14P, SER118H, SER118P, SER119H, SER119P, SER121H, SER178P, SER179P, SER85H, SER85P, VAL117P, VAL12H, VAL64P
• I-J: ALA130I, ALA131J, ALA142J, ALA143J, ALA174J, ALA34I, ALA43I, ALA55I, ALA61J, ALA97J, ARG111J, ARG135J, ARG142I, ARG211I, ARG38J, ARG45I, ARG98J, ASN102J, ASN137I, ASN138I, ASN210I, ASN53I, ASP103J, ASP107J, ASP122I, ASP150J, ASP167I, ASP170I, ASP1I, ASP50I, ASP62J, ASP92I, CYS133J, CYS134I, CYS146J, CYS88I, CYS96J, GLN124I, GLN160I, GLN166I, GLN177J, GLN37I, GLN38I, GLN39J, GLN42I, GLN89I, GLN90I, GLU123I, GLU139J, GLU161I, GLU165I, GLU213I, GLU46J, GLU6J, GLU99J, GLY100I, GLY100J, GLY101I, GLY110J, GLY112J, GLY145J, GLY168J, GLY212I, GLY41I, GLY42J, GLY44J, GLY99I, HIS101J, HIS170J, ILE117I, ILE48I, ILE51J, LEU108J, LEU125I, LEU130J, LEU135I, LEU136I, LEU144J, LEU147J, LEU175I, LEU176J, LEU179I, LEU181I, LEU184J, LEU33I, LEU45J, LEU46I, LEU47I, LEU4J, LEU96I, LYS126I, LYS149J, LYS169I, LYS207I, LYS215J, LYS39I, LYS43J, LYS59J, LYS65J, LYS93I, MET34J, PHE106J, PHE116I, PHE118I, PHE128J, PHE139I, PHE172J, PHE195J, PHE209I, PHE35J, PHE98I, PRO119I, PRO120I, PRO129J, PRO132J, PRO173J, PRO191J, PRO33J, PRO44I, PRO95I, SER114I, SER121I, SER126J, SER127I, SER131I, SER134J, SER136J, SER140J, SER159I, SER162I, SER167J, SER168I, SER174I, SER176I, SER177I, SER178J, SER179J, SER183J, SER185J, SER186J, SER192J, SER208I, SER49J, SER63J, THR129I, THR141J, THR164I, THR171J, THR172I, THR178I, THR180I, THR189J, THR56I, THR93J, THR97I, TRP104J, TRP109J, TRP35I, TRP36J, TRP47J, TRP50J, TRP94I, TYR105J, TYR173I, TYR186I, TYR192I, TYR32I, TYR36I, TYR49I, TYR60J, TYR86I, TYR87I, TYR91I, TYR95J, VAL115I, VAL127J, VAL132I, VAL133I, VAL148J, VAL163I, VAL169J, VAL175J, VAL187J, VAL188J, VAL190J, VAL213J, VAL217J, VAL37J, VAL48J, VAL85I
• J-L: ARG67J, ARG87J, GLY26L, GLY66J, THR28L
• K-L: ALA130K, ALA131L, ALA142L, ALA143L, ALA174L, ALA34K, ALA43K, ALA55K, ALA61L, ALA97L, ARG111L, ARG135L, ARG142K, ARG38L, ARG45K, ARG98L, ASN102L, ASN137K, ASN138K, ASN158K, ASN53K, ASP103L, ASP107L, ASP122K, ASP150L, ASP167K, ASP170K, ASP1K, ASP50K, ASP62L, ASP92K, CYS133L, CYS134K, CYS146L, CYS88K, CYS96L, GLN124K, GLN160K, GLN177L, GLN37K, GLN38K, GLN39L, GLN42K, GLN6K, GLN89K, GLN90K, GLU123K, GLU139L, GLU161K, GLU165K, GLU218L, GLU46L, GLU6L, GLU99L, GLY100K, GLY100L, GLY101K, GLY110L, GLY112L, GLY145L, GLY168L, GLY41K, GLY42L, GLY44L, GLY99K, HIS101L, HIS170L, ILE48K, LEU108L, LEU130L, LEU135K, LEU136K, LEU144L, LEU147L, LEU175K, LEU176L, LEU184L, LEU33K, LEU45L, LEU46K, LEU47K, LEU96K, LYS123L, LYS126K, LYS149L, LYS169K, LYS207K, LYS215L, LYS39K, LYS43L, LYS59L, LYS65L, LYS93K, PHE106L, PHE116K, PHE128L, PHE139K, PHE172L, PHE195L, PHE35L, PHE98K, PRO113K, PRO120K, PRO129L, PRO132L, PRO173L, PRO191L, PRO44K, PRO95K, SER121K, SER126L, SER127K, SER131K, SER134L, SER140L, SER159K, SER162K, SER167L, SER168K, SER174K, SER176K, SER177K, SER178L, SER179L, SER182K, SER183L, SER185L, SER186L, SER49L, THR129K, THR141L, THR164K, THR171L, THR172K, THR178K, THR180K, THR189L, THR206K, THR56K, THR58L, THR93L, THR97K, TRP104L, TRP109L, TRP35K, TRP36L, TRP47L, TRP50L, TRP94K, TYR105L, TYR173K, TYR32K, TYR36K, TYR49K, TYR60L, TYR86K, TYR87K, TYR91K, TYR95L, VAL115K, VAL127L, VAL132K, VAL133K, VAL163K, VAL169L, VAL175L, VAL187L, VAL188L, VAL190L, VAL205K, VAL213L, VAL217L, VAL37L, VAL48L, VAL85K
• K-M: ALA184K, ALA60M, ARG18M, ARG211K, ARG54M, ARG61M, ASN53M, ASP185K, GLU123K, GLU187K, GLY128K, GLY16M, GLY57M, GLY64M, HIS189K, ILE58M, LEU125K, LYS183K, LYS188K, LYS190K, PHE62M, PRO59M, SER52M, SER63M, SER65M, SER76M, SER77M, THR74M, TYR186K
• L-P: GLN13L, GLN13P
• M-N: ALA130M, ALA131N, ALA142N, ALA143N, ALA174N, ALA34M, ALA43M, ALA51M, ALA55M, ALA61N, ALA97N, ARG111N, ARG142M, ARG45M, ARG98N, ASN102N, ASN137M, ASN138M, ASN158M, ASN53M, ASP103N, ASP107N, ASP122M, ASP150N, ASP167M, ASP170M, ASP1M, ASP50M, ASP62N, ASP92M, CYS133N, CYS134M, CYS146N, CYS88M, CYS96N, GLN124M, GLN160M, GLN166M, GLN177N, GLN37M, GLN38M, GLN39N, GLN42M, GLN89M, GLN90M, GLU123M, GLU161M, GLU165M, GLU46N, GLU6N, GLU99N, GLY100M, GLY100N, GLY101M, GLY110N, GLY112N, GLY145N, GLY168N, GLY41M, GLY42N, GLY44N, GLY99M, HIS101N, HIS170N, ILE117M, ILE2M, ILE48M, LEU108N, LEU125M, LEU130N, LEU135M, LEU136M, LEU144N, LEU147N, LEU175M, LEU176N, LEU179M, LEU181M, LEU181N, LEU184N, LEU33M, LEU45N, LEU46M, LEU47M, LEU96M, LYS149N, LYS169M, LYS207M, LYS215N, LYS43N, LYS59N, LYS65N, LYS93M, PHE106N, PHE116M, PHE118M, PHE128N, PHE139M, PHE172N, PHE35N, PHE98M, PRO119M, PRO120M, PRO125N, PRO129N, PRO132N, PRO173N, PRO44M, PRO95M, SER114M, SER121M, SER126N, SER127M, SER131M, SER134N, SER138N, SER140N, SER162M, SER167N, SER168M, SER174M, SER176M, SER177M, SER178N, SER179N, SER183N, SER185N, SER186N, SER208M, SER31M, SER49N, SER63N, THR129M, THR137N, THR141N, THR164M, THR166N, THR171N, THR172M, THR178M, THR180M, THR189N, THR56M, THR93N, THR97M, TRP104N, TRP109N, TRP35M, TRP47N, TRP50N, TRP94M, TYR105N, TYR173M, TYR192M, TYR32M, TYR36M, TYR49M, TYR60N, TYR86M, TYR87M, TYR91M, TYR95N, VAL115M, VAL127N, VAL132M, VAL133M, VAL148N, VAL163M, VAL169N, VAL175N, VAL187N, VAL188N, VAL190N, VAL191M, VAL217N, VAL37N, VAL48N, VAL85M
• N-P: ALA24N, ARG67P, ARG87P, ASN77N, GLU1N, GLY26N, GLY66P, LYS65P, PHE27N, PHE29N, SER25N, THR28N
• O-P: ALA130O, ALA131P, ALA142P, ALA143P, ALA174P, ALA34O, ALA43O, ALA51O, ALA55O, ALA61P, ALA97P, ARG111P, ARG135P, ARG142O, ARG211O, ARG38P, ARG45O, ARG98P, ASN102P, ASN137O, ASN138O, ASN210O, ASP103P, ASP107P, ASP122O, ASP150P, ASP167O, ASP170O, ASP1O, ASP50O, ASP62P, ASP92O, CYS133P, CYS134O, CYS146P, CYS88O, CYS96P, GLN124O, GLN160O, GLN177P, GLN37O, GLN38O, GLN39P, GLN42O, GLN89O, GLN90O, GLU123O, GLU139P, GLU161O, GLU165O, GLU46P, GLU6P, GLU99P, GLY100O, GLY100P, GLY101O, GLY110P, GLY112P, GLY145P, GLY168P, GLY41O, GLY42P, GLY44P, GLY52P, GLY99O, HIS101P, HIS170P, ILE117O, ILE48O, ILE51P, ILE70P, LEU108P, LEU125O, LEU130P, LEU135O, LEU136O, LEU144P, LEU147P, LEU175O, LEU176P, LEU179O, LEU181O, LEU181P, LEU184P, LEU33O, LEU45P, LEU46O, LEU47O, LEU96O, LYS126O, LYS149P, LYS169O, LYS207O, LYS215P, LYS43P, LYS59P, LYS93O, PHE106P, PHE116O, PHE118O, PHE128P, PHE139O, PHE172P, PHE209O, PHE35P, PHE98O, PRO119O, PRO120O, PRO129P, PRO132P, PRO173P, PRO44O, PRO95O, SER114O, SER121O, SER126P, SER127O, SER131O, SER134P, SER140P, SER159O, SER162O, SER167P, SER168O, SER174O, SER176O, SER177O, SER178P, SER179P, SER183P, SER185P, SER186P, SER208O, SER49P, SER63P, THR129O, THR141P, THR164O, THR166P, THR171P, THR172O, THR178O, THR180O, THR189P, THR56O, THR58P, THR93P, THR97O, TRP104P, TRP109P, TRP35O, TRP36P, TRP47P, TRP50P, TRP94O, TYR105P, TYR173O, TYR186O, TYR32O, TYR36O, TYR49O, TYR60P, TYR86O, TYR87O, TYR91O, TYR95P, VAL115O, VAL127P, VAL132O, VAL133O, VAL148P, VAL163O, VAL169P, VAL175P, VAL187P, VAL188P, VAL190P, VAL213P, VAL217P, VAL2P, VAL37P, VAL48P, VAL85O