3KXX

structure of the mutant fibroblast growth factor receptor 1

• Total interactions analyzed: 6
• Total true interactions: 6
• Strongest Interaction:
  • Chains: B-C
  • Int. Res.: 151
  • Norm. En. per Res.: -3.702
• Hub Node: A(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-48.528	-19.2364	-101.371	-169.1354	56	7	2	3715	2	22	24
A-C	0.0	0.0	-0.3707	-0.3707	6	0	0	95	0	2	0
A-D	-66.4053	-44.7895	-404.557	-515.7519	147	28	8	16496	6	70	72
B-C	-110.538	-36.2783	-412.192	-559.0084	151	36	9	17100	3	72	76
B-D	0.0	0.0	-1.0517	-1.0517	7	0	0	99	0	3	1
C-D	0.0	-10.7043	-6.5403	-17.2446	26	0	0	378	1	28	15

Interface residues

• A-B: ALA671A, ALA671B, ALA739A, ALA739B, ARG675A, ARG675B, ARG744A, ARG744B, ASP652A, ASP652B, ASP674A, ASP674B, GLN680A, GLN680B, GLN743A, GLN743B, GLU670A, GLU670B, HIS649A, HIS649B, HIS650A, HIS650B, HIS738A, HIS738B, ILE648A, ILE648B, ILE651A, ILE651B, ILE676A, ILE676B, LEU672A, LYS618A, LYS655A, LYS655B, LYS714A, LYS714B, PHE673A, PHE673B, PRO669A, PRO669B, PRO741A, PRO741B, SER742A, SER742B, THR658A, THR658B, THR678A, THR678B, TYR653A, TYR653B, TYR654A, TYR654B, TYR677A, TYR677B, VAL740A, VAL740B
• A-C: ARG675A, GLU462C, LYS655A, THR658A, TYR463C, VAL460C
• A-D: ALA458D, ALA488A, ALA488D, ALA520A, ALA520D, ALA671A, ALA671D, ARG475A, ARG475D, ARG570A, ARG570D, ARG622A, ARG622D, ARG627A, ARG627D, ARG646D, ARG661A, ARG661D, ARG675A, ARG675D, ASN659A, ASN659D, ASP519A, ASP519D, ASP524A, ASP524D, ASP527A, ASP527D, ASP554A, ASP554D, ASP623D, ASP674A, ASP674D, CYS551A, CYS551D, GLN553A, GLN553D, GLU462A, GLU462D, GLU464A, GLU464D, GLU522A, GLU522D, GLU707A, GLU707D, GLU708A, GLU708D, GLY459D, GLY487A, GLY487D, GLY555A, GLY555D, GLY660A, GLY660D, GLY703A, GLY703D, HIS456D, ILE529A, ILE529D, LEU465A, LEU465D, LEU516A, LEU516D, LEU525A, LEU525D, LEU528A, LEU528D, LEU557A, LEU557D, LEU644A, LEU644D, LEU662A, LEU662D, LEU672A, LEU672D, LEU709A, LEU709D, LEU713A, LYS517A, LYS517D, LYS523A, LYS523D, LYS656A, LYS656D, LYS665A, LYS665D, LYS711A, LYS711D, LYS714A, LYS714D, MET457D, MET515A, MET515D, MET667A, MET667D, PHE489A, PHE489D, PHE673A, PHE673D, PHE710A, PHE710D, PRO556A, PRO556D, PRO663A, PRO663D, PRO669A, PRO669D, PRO700A, PRO700D, PRO702A, PRO702D, PRO705A, PRO705D, SER461A, SER461D, SER518A, SER518D, SER526A, SER526D, SER530D, SER699A, SER699D, THR521A, THR521D, THR552A, THR552D, THR657A, THR657D, THR658A, THR658D, TRP666A, TRP666D, TYR463A, TYR463D, TYR558A, TYR558D, TYR677A, TYR677D, TYR701A, TYR701D, VAL460D, VAL664A, VAL664D, VAL704A, VAL704D, VAL706A, VAL706D
• B-C: ALA458C, ALA488B, ALA488C, ALA520B, ALA520C, ALA625B, ALA625C, ALA668B, ALA668C, ALA671B, ALA671C, ARG475B, ARG475C, ARG570B, ARG570C, ARG622B, ARG627B, ARG627C, ARG661B, ARG661C, ARG675B, ARG675C, ASN659B, ASN659C, ASP519B, ASP519C, ASP524B, ASP524C, ASP527B, ASP527C, ASP554B, ASP554C, ASP623B, ASP623C, ASP674B, ASP674C, CYS551B, GLN553B, GLN553C, GLU462B, GLU462C, GLU464B, GLU464C, GLU522B, GLU522C, GLU670B, GLU707B, GLU707C, GLU708B, GLU708C, GLY459C, GLY487B, GLY487C, GLY555B, GLY555C, GLY660B, GLY660C, GLY703B, GLY703C, ILE529B, ILE529C, LEU465B, LEU465C, LEU516B, LEU516C, LEU525B, LEU525C, LEU528B, LEU528C, LEU557B, LEU557C, LEU644B, LEU644C, LEU662B, LEU662C, LEU672B, LEU672C, LEU709B, LEU709C, LEU713B, LEU713C, LYS517B, LYS517C, LYS523B, LYS523C, LYS656B, LYS656C, LYS665B, LYS665C, LYS711B, LYS711C, LYS714B, LYS714C, MET515B, MET515C, MET667B, MET667C, PHE489B, PHE489C, PHE673B, PHE673C, PHE710B, PHE710C, PRO556B, PRO556C, PRO663B, PRO663C, PRO669B, PRO669C, PRO700B, PRO700C, PRO702B, PRO702C, PRO705B, PRO705C, SER461B, SER461C, SER518B, SER518C, SER526B, SER526C, SER530B, SER530C, SER699B, SER699C, THR521B, THR521C, THR552B, THR552C, THR657B, THR657C, THR658B, THR658C, TRP666B, TRP666C, TYR463B, TYR463C, TYR558B, TYR558C, TYR677B, TYR677C, TYR701B, TYR701C, VAL460B, VAL460C, VAL664B, VAL664C, VAL704B, VAL704C, VAL706B, VAL706C
• B-D: ALA458D, ARG675B, GLU462D, GLY459D, LYS655B, SER461D, THR658B
• C-D: ALA458C, ALA458D, ARG470C, ARG470D, ASP468C, ASP468D, GLU462D, GLU464D, GLU467C, GLU467D, GLY459C, HIS650C, HIS650D, ILE651C, ILE651D, LYS536C, LYS655C, LYS656C, MET537D, PRO466C, PRO466D, PRO469C, PRO469D, TRP471C, TYR463D, TYR653D