3KQ4

structure of intrinsic factor-cobalamin bound to its receptor cubilin

• Total interactions analyzed: 15
• Total true interactions: 7
• Strongest Interaction:
  • Chains: C-D
  • Int. Res.: 98
  • Norm. En. per Res.: -3.9646
• Hub Node: A(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-76.8839	-61.8666	-250.595	-389.3455	100	25	6	10029	9	24	18
A-C	0.0	0.0	-11.0862	-11.0862	58	1	0	1026	0	8	8
A-E	0.0	-4.0423	-18.1869	-22.2292	14	0	0	739	0	2	0
A-F	0.0	0.0	-23.4461	-23.4461	26	8	0	1448	0	1	2
C-D	-76.9342	-61.89	-249.711	-388.5352	98	24	6	10012	9	24	18
C-E	-106.5492	-47.262	-304.575	-458.3862	116	14	0	10912	2	24	18
E-F	-76.9657	-61.8991	-250.937	-389.8018	100	24	6	10028	9	24	18

Interface residues

• A-B: ALA1098B, ALA121A, ALA127A, ALA129A, ALA131A, ALA158A, ALA163A, ARG1151B, ARG1349B, ARG1377B, ARG1378B, ARG156A, ARG196A, ARG323A, ASN1070B, ASN1071B, ASN1101B, ASN126A, ASN1303B, ASN164A, ASN320A, ASN375A, ASN379A, ASN381A, ASP1105B, ASP1146B, ASP1149B, ASP1336B, ASP1373B, CYS1333B, GLN1147B, GLN1304B, GLN201A, GLN321A, GLN416A, GLU1096B, GLU1097B, GLU128A, GLU1302B, GLU1328B, GLU1339B, GLU1379B, GLU192A, GLU193A, GLU326A, GLY1100B, GLY1374B, GLY1376B, GLY194A, GLY324A, HIS1305B, HIS1329B, HIS382A, ILE1099B, ILE1148B, ILE1331B, ILE153A, ILE376A, LEU1370B, LEU1371B, LEU151A, LEU161A, LEU162A, LEU198A, LEU322A, LEU327A, LYS159A, LYS383A, PHE132A, PHE157A, PHE199A, PHE414A, PRO122A, PRO125A, PRO152A, SER1145B, SER123A, SER124A, SER1334B, SER165A, SER166A, SER197A, THR1104B, THR1150B, THR1335B, THR1372B, THR160A, THR384A, THR415A, TRP120A, TYR1068B, TYR1102B, TYR1103B, TYR1300B, TYR1337B, TYR195A, VAL1375B, VAL155A, VAL202A, VAL325A
• A-C: ALA400C, ALA51A, ALA51C, ARG104A, ARG104C, ARG352A, ARG352C, ASN45A, ASN45C, ASP108A, ASP108C, GLN351A, GLN351C, GLN78A, GLN78C, GLU348A, GLU348C, GLY340A, GLY340C, LEU344C, LEU368A, LEU368C, LYS109A, LYS109C, LYS338A, LYS338C, LYS73A, LYS73C, MET363A, MET363C, MET80A, MET80C, PRO299A, PRO299C, SER341A, SER341C, SER46A, SER46C, SER49A, SER49C, SER50A, SER50C, SER81A, SER81C, SER82A, SER82C, THR297A, THR297C, THR48A, THR48C, TYR52A, TYR52C, TYR77A, TYR77C, VAL337A, VAL337C, VAL345A, VAL345C
• A-E: ALA309A, ASN311A, GLU192E, GLU193E, GLY190E, GLY194E, LEU198E, LYS338A, SER191E, SER197E, SER308A, SER310A, TYR195E, VAL337A
• A-F: ALA309A, ARG1151F, ASN1063F, ASN1066F, ASN1067F, ASN1070F, ASN1071F, ASN311A, ASN406A, ASP1146F, ASP1149F, GLN1147F, HIS407A, ILE1148F, ILE312A, PHE1064F, PHE405A, PRO1065F, PRO1069F, SER1152F, SER308A, SER310A, THR1150F, THR313A, TYR1068F, VAL335A
• C-D: ALA1098D, ALA121C, ALA127C, ALA129C, ALA131C, ALA158C, ALA163C, ARG1151D, ARG1349D, ARG1377D, ARG1378D, ARG156C, ARG196C, ARG323C, ASN1070D, ASN1071D, ASN1101D, ASN126C, ASN1303D, ASN164C, ASN320C, ASN375C, ASN379C, ASN381C, ASP1105D, ASP1146D, ASP1149D, ASP1336D, ASP1373D, CYS1333D, GLN1147D, GLN1304D, GLN201C, GLN321C, GLN416C, GLU1096D, GLU1097D, GLU128C, GLU1302D, GLU1328D, GLU1339D, GLU1379D, GLU192C, GLU193C, GLU326C, GLY1100D, GLY1374D, GLY1376D, GLY194C, GLY324C, HIS1305D, HIS1329D, HIS382C, ILE1099D, ILE1148D, ILE1331D, ILE153C, ILE376C, LEU1370D, LEU1371D, LEU151C, LEU161C, LEU162C, LEU198C, LEU322C, LEU327C, LYS159C, LYS383C, PHE132C, PHE157C, PHE199C, PHE414C, PRO122C, PRO125C, PRO152C, SER1145D, SER123C, SER124C, SER1334D, SER165C, SER166C, SER197C, THR1104D, THR1150D, THR1335D, THR1372D, THR160C, THR384C, THR415C, TRP120C, TYR1102D, TYR1103D, TYR1337D, TYR195C, VAL1375D, VAL155C, VAL202C, VAL325C
• C-E: ALA149C, ALA149E, ALA66C, ALA66E, ALA71C, ALA71E, ALA98C, ALA98E, ARG104C, ARG104E, ARG196C, ARG196E, ASN146C, ASN146E, ASN185C, ASN185E, ASN62C, ASN62E, ASP105C, ASP105E, ASP282C, ASP282E, ASP291C, ASP291E, CYS103C, CYS103E, CYS182C, CYS182E, CYS288C, CYS288E, GLN144C, GLN144E, GLN285C, GLN285E, GLN72C, GLN72E, GLU148C, GLU148E, GLU192C, GLU192E, GLU193C, GLU193E, GLY107C, GLY107E, GLY190C, GLY190E, ILE187C, ILE187E, LEU151C, LEU151E, LEU281C, LEU281E, LEU58C, LEU58E, LEU69C, LEU69E, LEU74C, LEU74E, LEU75C, LEU75E, LEU99C, LEU99E, LYS145C, LYS145E, LYS186C, LYS186E, LYS70C, LYS70E, LYS73C, LYS73E, MET183C, MET183E, MET61C, MET61E, MET80C, MET80E, PRO106C, PRO106E, PRO188C, PRO188E, PRO284C, PRO284E, PRO290C, PRO290E, SER101C, SER101E, SER102C, SER102E, SER147C, SER147E, SER191C, SER191E, SER289C, SER289E, THR100C, THR100E, THR150C, THR150E, THR181C, THR181E, THR287C, THR287E, THR76C, THR76E, TYR184C, TYR184E, TYR195C, TYR195E, TYR77C, TYR77E, VAL189C, VAL189E, VAL283C, VAL283E, VAL286C, VAL286E
• E-F: ALA1098F, ALA121E, ALA127E, ALA129E, ALA131E, ALA158E, ALA163E, ARG1151F, ARG1349F, ARG1377F, ARG1378F, ARG156E, ARG196E, ARG323E, ASN1070F, ASN1071F, ASN1101F, ASN126E, ASN1303F, ASN164E, ASN320E, ASN375E, ASN379E, ASN381E, ASP1105F, ASP1146F, ASP1149F, ASP1336F, ASP1373F, CYS1333F, GLN1147F, GLN1304F, GLN201E, GLN321E, GLN416E, GLU1096F, GLU1097F, GLU128E, GLU1302F, GLU1328F, GLU1339F, GLU1379F, GLU192E, GLU193E, GLU326E, GLY1100F, GLY1374F, GLY1376F, GLY194E, GLY324E, HIS1305F, HIS1329F, HIS382E, ILE1099F, ILE1148F, ILE1331F, ILE153E, ILE376E, LEU1370F, LEU1371F, LEU151E, LEU161E, LEU162E, LEU198E, LEU322E, LEU327E, LYS159E, LYS383E, PHE132E, PHE157E, PHE199E, PHE414E, PRO122E, PRO125E, PRO152E, SER1145F, SER123E, SER124E, SER1334F, SER165E, SER166E, SER197E, THR1104F, THR1150F, THR1335F, THR1372F, THR160E, THR384E, THR415E, TRP120E, TYR1068F, TYR1102F, TYR1103F, TYR1300F, TYR1337F, TYR195E, VAL1375F, VAL155E, VAL202E, VAL325E