3KL9

crystal structure of pepa from streptococcus pneumoniae

• Total interactions analyzed: 66
• Total true interactions: 18
• Strongest Interaction:
  • Chains: A-D
  • Int. Res.: 159
  • Norm. En. per Res.: -3.4343
• Hub Node: A(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-20.4327	1.861	-305.369	-323.9408	113	8	3	11826	1	28	39
A-C	-18.785	-5.8888	-298.774	-323.4479	114	7	2	11735	1	30	36
A-D	-43.2513	-54.1617	-448.636	-546.049	159	36	10	18148	4	34	35
B-C	-24.4121	-4.3945	-298.826	-327.6326	115	10	2	11832	1	30	38
B-G	-39.28	-51.4424	-407.395	-498.1174	160	39	10	18154	4	33	32
C-J	-46.7445	-53.3589	-412.963	-513.0663	160	31	10	17879	4	32	34
D-H	-26.2828	-8.267	-296.3	-330.8499	115	9	2	11724	1	28	37
D-L	-18.4965	-6.3442	-296.72	-321.5608	114	5	2	11629	1	29	38
E-F	-22.6595	-9.027	-296.997	-328.6835	111	9	2	11607	1	28	38
E-G	-32.5733	-13.6438	-302.074	-348.2911	114	12	2	11800	1	28	39
E-H	-60.126	-57.1625	-411.783	-529.0714	158	38	10	18210	4	34	33
F-G	-21.9559	-7.1608	-303.878	-332.9948	115	8	2	11692	1	28	38
F-K	-38.939	-56.8343	-435.536	-531.3093	161	40	10	17929	4	32	33
H-L	-20.3666	-9.9043	-295.475	-325.7458	116	7	2	11590	1	28	38
I-J	-22.5723	-10.772	-300.376	-333.7203	114	9	2	11722	1	29	37
I-K	-12.9848	-10.9845	-296.22	-320.1893	116	8	2	11707	1	28	38
I-L	-33.7983	-53.3785	-403.15	-490.3268	158	40	10	17875	4	32	34
J-K	-39.5627	-7.3264	-297.911	-344.8001	116	12	2	11778	1	28	39

Interface residues

• A-B: ALA135A, ALA220A, ALA22A, ALA26A, ALA297A, ALA297B, ALA298B, ARG106A, ARG155A, ARG218A, ARG257B, ARG25A, ARG29A, ARG84A, ASN302A, ASN302B, ASP158A, ASP260B, ASP271B, ASP42A, ASP68A, CYS288B, GLN212A, GLN247B, GLN285B, GLU150A, GLU214A, GLU21A, GLU230B, GLU278B, GLU76A, GLU87A, GLY157A, GLY19A, GLY216A, GLY219A, GLY245B, GLY246B, GLY262B, GLY268B, GLY289B, GLY296B, GLY303B, GLY304B, GLY43A, GLY45A, GLY46A, GLY89A, HIS20A, HIS221A, HIS221B, HIS263B, HIS299B, HIS353B, ILE154A, ILE256B, ILE351B, ILE47A, ILE77A, ILE88A, LEU104A, LEU217A, LEU264B, LEU265B, LEU266B, LEU273B, LEU274B, LEU300B, LEU44A, LYS146A, LYS226A, LYS270B, LYS290B, LYS301A, LYS301B, LYS352B, LYS78A, MET67A, MET73A, PHE227A, PHE258B, PHE272B, PRO156A, PRO23A, PRO261B, PRO267B, PRO306B, SER18A, SER223A, SER307B, SER75A, THR105A, THR159A, THR222A, THR224A, THR225A, THR225B, THR275B, THR41A, TYR259B, TYR284B, TYR286B, TYR287B, TYR354B, VAL17A, VAL211A, VAL215A, VAL305B, VAL39A, VAL40A, VAL74A, VAL85A, VAL86A
• A-C: ALA135C, ALA220C, ALA22C, ALA26C, ALA295A, ALA297A, ALA297C, ALA298A, ARG106C, ARG155C, ARG218C, ARG25C, ARG29C, ARG84C, ASN302A, ASN302C, ASP107C, ASP158C, ASP260A, ASP271A, ASP42C, ASP68C, CYS288A, GLN212C, GLN247A, GLN285A, GLU150C, GLU214C, GLU21C, GLU230A, GLU278A, GLU76C, GLU87C, GLY157C, GLY19C, GLY216C, GLY219C, GLY245A, GLY246A, GLY262A, GLY268A, GLY289A, GLY296A, GLY303A, GLY304A, GLY43C, GLY45C, GLY46C, GLY89C, HIS20C, HIS221A, HIS221C, HIS263A, HIS299A, HIS353A, ILE154C, ILE256A, ILE351A, ILE47C, ILE77C, ILE88C, LEU104C, LEU217C, LEU264A, LEU265A, LEU266A, LEU273A, LEU274A, LEU300A, LEU44C, LYS146C, LYS226C, LYS270A, LYS290A, LYS301A, LYS301C, LYS352A, LYS78C, MET67C, MET73C, PHE227C, PHE258A, PHE272A, PRO156C, PRO23C, PRO261A, PRO267A, PRO306A, SER18C, SER223C, SER307A, SER75C, THR105C, THR159C, THR222C, THR224C, THR225A, THR225C, THR275A, THR41C, TYR259A, TYR284A, TYR286A, TYR287A, TYR354A, VAL17C, VAL211C, VAL215C, VAL305A, VAL39C, VAL40C, VAL74C, VAL85C, VAL86C
• A-D: ALA133A, ALA133D, ALA144A, ALA144D, ALA149A, ALA149D, ALA166A, ALA166D, ALA170A, ALA170D, ARG100A, ARG100D, ARG315A, ARG315D, ARG84A, ARG84D, ASN171A, ASN171D, ASN174A, ASN174D, ASN92A, ASN92D, ASP136A, ASP136D, ASP140A, ASP140D, ASP145A, ASP145D, ASP163A, ASP163D, ASP242A, ASP242D, ASP80A, ASP80D, GLN321A, GLN321D, GLN99A, GLN99D, GLU110A, GLU110D, GLU13A, GLU13D, GLU148A, GLU148D, GLU172A, GLU172D, GLY116A, GLY116D, GLY141A, GLY141D, GLY142A, GLY142D, GLY245A, GLY245D, GLY251A, GLY81A, GLY81D, HIS109A, HIS109D, HIS318A, HIS318D, HIS320A, HIS320D, ILE111A, ILE111D, ILE114A, ILE114D, ILE137A, ILE137D, ILE154A, ILE154D, ILE167A, ILE167D, ILE175A, ILE175D, ILE176A, ILE176D, ILE250A, ILE250D, ILE317A, ILE317D, LEU103A, LEU103D, LEU168A, LEU168D, LEU323A, LEU323D, LYS102A, LYS102D, LYS173A, LYS173D, LYS178A, LYS178D, LYS249A, LYS249D, LYS78A, LYS78D, LYS9A, LYS9D, MET94A, MET94D, PHE101A, PHE101D, PHE139A, PHE139D, PHE143A, PHE143D, PHE152A, PHE152D, PHE5A, PHE5D, PHE83A, PHE83D, PRO112A, PRO112D, PRO132A, PRO132D, PRO93A, PRO93D, SER115A, SER115D, SER151A, SER151D, SER164A, SER164D, SER165A, SER165D, SER177A, SER177D, SER319A, SER319D, SER97A, SER97D, SER98A, SER98D, THR169A, THR169D, THR322A, THR322D, THR82A, THR82D, TRP91A, TRP91D, TYR244A, TYR244D, TYR316A, TYR316D, TYR324A, TYR324D, VAL113A, VAL113D, VAL138A, VAL138D, VAL243A, VAL243D, VAL95A, VAL95D, VAL96A, VAL96D
• B-C: ALA135B, ALA220B, ALA22B, ALA26B, ALA297B, ALA297C, ALA298C, ARG106B, ARG155B, ARG218B, ARG25B, ARG29B, ARG84B, ASN302B, ASN302C, ASP158B, ASP260C, ASP271C, ASP42B, ASP68B, CYS288C, GLN212B, GLN247C, GLN285C, GLU150B, GLU214B, GLU21B, GLU230C, GLU278C, GLU76B, GLU87B, GLY153B, GLY157B, GLY19B, GLY216B, GLY219B, GLY245C, GLY246C, GLY262C, GLY268C, GLY289C, GLY296C, GLY303C, GLY304C, GLY43B, GLY45B, GLY46B, GLY89B, HIS20B, HIS221B, HIS221C, HIS263C, HIS299C, HIS353C, ILE154B, ILE256C, ILE351C, ILE47B, ILE77B, ILE88B, LEU104B, LEU217B, LEU264C, LEU265C, LEU266C, LEU273C, LEU274C, LEU300C, LEU44B, LYS146B, LYS226B, LYS270C, LYS290C, LYS301B, LYS301C, LYS352C, LYS78B, MET269C, MET67B, MET73B, PHE227B, PHE258C, PHE272C, PRO156B, PRO23B, PRO261C, PRO267C, PRO306C, SER18B, SER223B, SER307C, SER75B, THR105B, THR159B, THR222B, THR224B, THR225B, THR225C, THR275C, THR41B, TYR259C, TYR284C, TYR286C, TYR287C, TYR354C, VAL17B, VAL211B, VAL215B, VAL231C, VAL305C, VAL39B, VAL40B, VAL74B, VAL85B, VAL86B
• B-G: ALA133B, ALA133G, ALA144B, ALA144G, ALA149B, ALA149G, ALA166B, ALA166G, ALA170B, ALA170G, ARG100B, ARG100G, ARG315B, ARG315G, ARG84B, ARG84G, ASN171B, ASN171G, ASN174B, ASN174G, ASN92B, ASN92G, ASP136B, ASP136G, ASP140B, ASP140G, ASP145B, ASP145G, ASP163B, ASP163G, ASP242B, ASP242G, ASP80B, ASP80G, GLN321B, GLN321G, GLN99B, GLN99G, GLU110B, GLU110G, GLU13B, GLU13G, GLU148B, GLU148G, GLU172B, GLU172G, GLY116B, GLY116G, GLY141B, GLY141G, GLY142B, GLY142G, GLY245B, GLY245G, GLY251B, GLY251G, GLY81B, GLY81G, HIS109B, HIS109G, HIS318B, HIS318G, HIS320B, HIS320G, ILE111B, ILE111G, ILE114B, ILE114G, ILE137B, ILE137G, ILE154B, ILE154G, ILE167B, ILE167G, ILE175B, ILE175G, ILE176B, ILE176G, ILE250B, ILE250G, ILE317B, ILE317G, LEU103B, LEU103G, LEU168B, LEU168G, LEU323B, LEU323G, LYS102B, LYS102G, LYS173B, LYS173G, LYS178B, LYS178G, LYS249B, LYS249G, LYS78B, LYS78G, LYS9B, LYS9G, MET94B, MET94G, PHE101B, PHE101G, PHE139B, PHE139G, PHE143B, PHE143G, PHE152B, PHE152G, PHE5B, PHE5G, PHE83B, PHE83G, PRO112B, PRO112G, PRO132B, PRO132G, PRO93B, PRO93G, SER115B, SER115G, SER151B, SER151G, SER164B, SER164G, SER165B, SER165G, SER177B, SER177G, SER319B, SER319G, SER97B, SER97G, SER98B, SER98G, THR169B, THR169G, THR322B, THR322G, THR82B, THR82G, TRP91B, TRP91G, TYR244B, TYR244G, TYR316B, TYR316G, TYR324B, TYR324G, VAL113B, VAL113G, VAL138B, VAL138G, VAL243B, VAL243G, VAL95B, VAL95G, VAL96B, VAL96G
• C-J: ALA133C, ALA133J, ALA144C, ALA144J, ALA149C, ALA149J, ALA166C, ALA166J, ALA170C, ALA170J, ARG100C, ARG100J, ARG315C, ARG315J, ARG84C, ARG84J, ASN171C, ASN171J, ASN174C, ASN174J, ASN92C, ASN92J, ASP136C, ASP136J, ASP140C, ASP140J, ASP145C, ASP145J, ASP163C, ASP163J, ASP242C, ASP242J, ASP80C, ASP80J, GLN321C, GLN321J, GLN99C, GLN99J, GLU110C, GLU110J, GLU13C, GLU13J, GLU148C, GLU148J, GLU172C, GLU172J, GLY116C, GLY116J, GLY141C, GLY141J, GLY142C, GLY142J, GLY245C, GLY245J, GLY251C, GLY81C, GLY81J, HIS109C, HIS109J, HIS318C, HIS318J, HIS320C, HIS320J, ILE111C, ILE111J, ILE114C, ILE114J, ILE137C, ILE137J, ILE154C, ILE154J, ILE167C, ILE167J, ILE175C, ILE175J, ILE176C, ILE176J, ILE250C, ILE250J, ILE317C, ILE317J, LEU103C, LEU103J, LEU168C, LEU168J, LEU323C, LEU323J, LYS102C, LYS102J, LYS173C, LYS173J, LYS178C, LYS178J, LYS249C, LYS249J, LYS78C, LYS78J, LYS9C, LYS9J, MET94C, MET94J, PHE101C, PHE101J, PHE139C, PHE139J, PHE143C, PHE143J, PHE152C, PHE152J, PHE5C, PHE5J, PHE83C, PHE83J, PRO112C, PRO112J, PRO132C, PRO132J, PRO93C, PRO93J, SER115C, SER115J, SER151C, SER151J, SER164C, SER164J, SER165C, SER165J, SER177C, SER177J, SER319C, SER319J, SER97C, SER97J, SER98C, SER98J, THR12J, THR169C, THR169J, THR322C, THR322J, THR82C, THR82J, TRP91C, TRP91J, TYR244C, TYR244J, TYR316C, TYR316J, TYR324C, TYR324J, VAL113C, VAL113J, VAL138C, VAL138J, VAL243C, VAL243J, VAL95C, VAL95J, VAL96C, VAL96J
• D-H: ALA135H, ALA220H, ALA22H, ALA26H, ALA295D, ALA297D, ALA297H, ALA298D, ARG106H, ARG155H, ARG218H, ARG25H, ARG29H, ARG84H, ASN302D, ASN302H, ASP158H, ASP260D, ASP271D, ASP42H, ASP68H, CYS288D, GLN212H, GLN247D, GLN285D, GLU150H, GLU214H, GLU21H, GLU230D, GLU278D, GLU76H, GLU87H, GLY153H, GLY157H, GLY19H, GLY216H, GLY219H, GLY245D, GLY246D, GLY262D, GLY268D, GLY289D, GLY296D, GLY303D, GLY304D, GLY43H, GLY45H, GLY46H, GLY89H, HIS20H, HIS221D, HIS221H, HIS263D, HIS299D, HIS353D, ILE154H, ILE256D, ILE351D, ILE47H, ILE77H, ILE88H, LEU104H, LEU217H, LEU264D, LEU265D, LEU266D, LEU273D, LEU274D, LEU300D, LEU44H, LYS146H, LYS226H, LYS270D, LYS290D, LYS301D, LYS301H, LYS352D, LYS78H, MET269D, MET67H, MET73H, PHE227H, PHE258D, PHE272D, PRO156H, PRO23H, PRO261D, PRO267D, PRO306D, SER18H, SER223H, SER307D, SER75H, THR105H, THR159H, THR222H, THR224H, THR225D, THR225H, THR275D, THR41H, TYR259D, TYR284D, TYR286D, TYR287D, TYR354D, VAL17H, VAL211H, VAL215H, VAL231D, VAL305D, VAL40H, VAL74H, VAL85H, VAL86H
• D-L: ALA135D, ALA220D, ALA22D, ALA26D, ALA295L, ALA297D, ALA297L, ALA298L, ARG106D, ARG155D, ARG218D, ARG25D, ARG29D, ARG84D, ASN302D, ASN302L, ASP158D, ASP260L, ASP271L, ASP42D, ASP68D, CYS288L, GLN212D, GLN247L, GLN285L, GLU150D, GLU214D, GLU21D, GLU230L, GLU278L, GLU76D, GLU87D, GLY153D, GLY157D, GLY19D, GLY216D, GLY219D, GLY245L, GLY246L, GLY262L, GLY268L, GLY289L, GLY296L, GLY303L, GLY304L, GLY43D, GLY45D, GLY46D, GLY89D, HIS20D, HIS221D, HIS221L, HIS263L, HIS299L, HIS353L, ILE154D, ILE256L, ILE351L, ILE47D, ILE77D, ILE88D, LEU104D, LEU217D, LEU264L, LEU265L, LEU266L, LEU273L, LEU274L, LEU300L, LEU44D, LYS146D, LYS226D, LYS270L, LYS290L, LYS301D, LYS301L, LYS352L, LYS78D, MET67D, MET73D, PHE227D, PHE258L, PHE272L, PRO156D, PRO23D, PRO261L, PRO267L, PRO306L, SER18D, SER223D, SER307L, SER75D, THR105D, THR159D, THR222D, THR224D, THR225D, THR225L, THR275L, THR41D, TYR259L, TYR284L, TYR286L, TYR287L, TYR354L, VAL17D, VAL211D, VAL215D, VAL305L, VAL39D, VAL40D, VAL74D, VAL85D, VAL86D
• E-F: ALA135E, ALA220E, ALA22E, ALA26E, ALA295F, ALA297E, ALA297F, ALA298F, ARG106E, ARG155E, ARG218E, ARG25E, ARG29E, ARG84E, ASN302E, ASN302F, ASP158E, ASP260F, ASP271F, ASP42E, ASP68E, CYS288F, GLN212E, GLN247F, GLN285F, GLU214E, GLU21E, GLU230F, GLU278F, GLU76E, GLU87E, GLY157E, GLY19E, GLY216E, GLY219E, GLY245F, GLY246F, GLY262F, GLY268F, GLY289F, GLY296F, GLY303F, GLY304F, GLY43E, GLY45E, GLY46E, GLY89E, HIS20E, HIS221E, HIS221F, HIS263F, HIS299F, HIS353F, ILE154E, ILE256F, ILE351F, ILE47E, ILE77E, ILE88E, LEU104E, LEU217E, LEU264F, LEU265F, LEU266F, LEU273F, LEU274F, LEU300F, LEU44E, LYS146E, LYS226E, LYS270F, LYS290F, LYS301E, LYS301F, LYS352F, LYS78E, MET67E, MET73E, PHE227E, PHE258F, PHE272F, PRO156E, PRO23E, PRO261F, PRO267F, PRO306F, SER18E, SER223E, SER307F, SER75E, THR105E, THR159E, THR222E, THR224E, THR225E, THR225F, THR275F, THR41E, TYR259F, TYR284F, TYR286F, TYR287F, TYR354F, VAL17E, VAL211E, VAL215E, VAL305F, VAL40E, VAL74E, VAL85E, VAL86E
• E-G: ALA135G, ALA220G, ALA22G, ALA26G, ALA295E, ALA297E, ALA297G, ALA298E, ARG106G, ARG155G, ARG218G, ARG25G, ARG29G, ARG84G, ASN302E, ASN302G, ASP158G, ASP260E, ASP271E, ASP42G, ASP68G, CYS288E, GLN212G, GLN247E, GLN285E, GLU150G, GLU214G, GLU21G, GLU230E, GLU278E, GLU76G, GLU87G, GLY157G, GLY19G, GLY216G, GLY219G, GLY245E, GLY246E, GLY262E, GLY268E, GLY289E, GLY296E, GLY303E, GLY304E, GLY43G, GLY45G, GLY46G, GLY89G, HIS20G, HIS221E, HIS221G, HIS263E, HIS299E, HIS353E, ILE154G, ILE256E, ILE351E, ILE47G, ILE77G, ILE88G, LEU104G, LEU217G, LEU264E, LEU265E, LEU266E, LEU273E, LEU274E, LEU300E, LEU44G, LYS146G, LYS226G, LYS270E, LYS290E, LYS301E, LYS301G, LYS352E, LYS78G, MET269E, MET67G, MET73G, PHE227G, PHE258E, PHE272E, PRO156G, PRO23G, PRO261E, PRO267E, PRO306E, SER18G, SER223G, SER307E, SER75G, THR105G, THR159G, THR222G, THR224G, THR225E, THR225G, THR275E, THR41G, TYR259E, TYR284E, TYR286E, TYR287E, TYR354E, VAL17G, VAL211G, VAL215G, VAL231E, VAL305E, VAL40G, VAL74G, VAL85G, VAL86G
• E-H: ALA133E, ALA133H, ALA144E, ALA144H, ALA149E, ALA149H, ALA166E, ALA166H, ALA170E, ALA170H, ARG100E, ARG100H, ARG315E, ARG315H, ARG84E, ARG84H, ASN171E, ASN171H, ASN174E, ASN174H, ASN92E, ASN92H, ASP136E, ASP136H, ASP140E, ASP140H, ASP145E, ASP145H, ASP163E, ASP163H, ASP242E, ASP242H, ASP80E, ASP80H, GLN321E, GLN321H, GLN99E, GLN99H, GLU110E, GLU110H, GLU13E, GLU13H, GLU148E, GLU148H, GLU172E, GLU172H, GLY116E, GLY116H, GLY141E, GLY141H, GLY142E, GLY142H, GLY245E, GLY245H, GLY81E, GLY81H, HIS109E, HIS109H, HIS318E, HIS318H, HIS320E, HIS320H, ILE111E, ILE111H, ILE114E, ILE114H, ILE137E, ILE137H, ILE154E, ILE154H, ILE167E, ILE167H, ILE175E, ILE175H, ILE176E, ILE176H, ILE250E, ILE250H, ILE317E, ILE317H, LEU103E, LEU103H, LEU168E, LEU168H, LEU323E, LEU323H, LYS102E, LYS102H, LYS173E, LYS173H, LYS178E, LYS178H, LYS249E, LYS249H, LYS78E, LYS78H, LYS9E, LYS9H, MET94E, MET94H, PHE101E, PHE101H, PHE139E, PHE139H, PHE143E, PHE143H, PHE152E, PHE152H, PHE5E, PHE5H, PHE83E, PHE83H, PRO112E, PRO112H, PRO132E, PRO132H, PRO93E, PRO93H, SER115E, SER115H, SER151E, SER151H, SER164E, SER164H, SER165E, SER165H, SER177E, SER177H, SER319E, SER319H, SER97E, SER97H, SER98E, SER98H, THR169E, THR169H, THR322E, THR322H, THR82E, THR82H, TRP91E, TRP91H, TYR244E, TYR244H, TYR316E, TYR316H, TYR324E, TYR324H, VAL113E, VAL113H, VAL138E, VAL138H, VAL243E, VAL243H, VAL95E, VAL95H, VAL96E, VAL96H
• F-G: ALA135F, ALA220F, ALA22F, ALA26F, ALA297F, ALA297G, ALA298G, ARG106F, ARG155F, ARG218F, ARG25F, ARG29F, ARG84F, ASN302F, ASN302G, ASP107F, ASP158F, ASP260G, ASP271G, ASP42F, ASP68F, CYS288G, GLN212F, GLN247G, GLN285G, GLU150F, GLU214F, GLU21F, GLU230G, GLU278G, GLU76F, GLU87F, GLY153F, GLY157F, GLY19F, GLY216F, GLY219F, GLY245G, GLY246G, GLY262G, GLY268G, GLY289G, GLY296G, GLY303G, GLY304G, GLY43F, GLY45F, GLY46F, GLY89F, HIS20F, HIS221F, HIS221G, HIS263G, HIS299G, HIS353G, ILE154F, ILE256G, ILE351G, ILE47F, ILE77F, ILE88F, LEU104F, LEU217F, LEU264G, LEU265G, LEU266G, LEU273G, LEU274G, LEU300G, LEU44F, LYS146F, LYS226F, LYS270G, LYS290G, LYS301F, LYS301G, LYS352G, LYS78F, MET67F, MET73F, PHE227F, PHE258G, PHE272G, PRO156F, PRO23F, PRO261G, PRO267G, PRO306G, SER18F, SER223F, SER307G, SER75F, THR105F, THR159F, THR222F, THR224F, THR225F, THR225G, THR275G, THR41F, TYR259G, TYR284G, TYR286G, TYR287G, TYR354G, VAL17F, VAL211F, VAL215F, VAL231G, VAL305G, VAL39F, VAL40F, VAL74F, VAL85F, VAL86F
• F-K: ALA133F, ALA133K, ALA144F, ALA144K, ALA149F, ALA149K, ALA166F, ALA166K, ALA170F, ALA170K, ARG100F, ARG100K, ARG315F, ARG315K, ARG84F, ARG84K, ASN171F, ASN171K, ASN174F, ASN174K, ASN92F, ASN92K, ASP136F, ASP136K, ASP140F, ASP140K, ASP145F, ASP145K, ASP163F, ASP163K, ASP242F, ASP242K, ASP80F, ASP80K, GLN321F, GLN321K, GLN99F, GLN99K, GLU110F, GLU110K, GLU13F, GLU13K, GLU148F, GLU148K, GLU172F, GLU172K, GLY116F, GLY116K, GLY141F, GLY141K, GLY142F, GLY142K, GLY245F, GLY245K, GLY251F, GLY251K, GLY81F, GLY81K, HIS109F, HIS109K, HIS318F, HIS318K, HIS320F, HIS320K, ILE111F, ILE111K, ILE114F, ILE114K, ILE137F, ILE137K, ILE154F, ILE154K, ILE167F, ILE167K, ILE175F, ILE175K, ILE176F, ILE176K, ILE250F, ILE250K, ILE317F, ILE317K, LEU103F, LEU103K, LEU168F, LEU168K, LEU323F, LEU323K, LYS102F, LYS102K, LYS173F, LYS173K, LYS178F, LYS178K, LYS249F, LYS249K, LYS78F, LYS78K, LYS9F, LYS9K, MET94F, MET94K, PHE101F, PHE101K, PHE139F, PHE139K, PHE143F, PHE143K, PHE152F, PHE152K, PHE5F, PHE5K, PHE83F, PHE83K, PRO112F, PRO112K, PRO132F, PRO132K, PRO93F, PRO93K, SER115F, SER115K, SER151F, SER151K, SER164F, SER164K, SER165F, SER165K, SER177F, SER177K, SER319F, SER319K, SER97F, SER97K, SER98F, SER98K, THR12F, THR169F, THR169K, THR322F, THR322K, THR82F, THR82K, TRP91F, TRP91K, TYR244F, TYR244K, TYR316F, TYR316K, TYR324F, TYR324K, VAL113F, VAL113K, VAL138F, VAL138K, VAL243F, VAL243K, VAL95F, VAL95K, VAL96F, VAL96K
• H-L: ALA135L, ALA220L, ALA22L, ALA26L, ALA295H, ALA297H, ALA297L, ALA298H, ARG106L, ARG155L, ARG218L, ARG25L, ARG29L, ARG84L, ASN302H, ASN302L, ASP158L, ASP228L, ASP260H, ASP271H, ASP42L, ASP68L, CYS288H, GLN212L, GLN247H, GLN285H, GLU150L, GLU214L, GLU21L, GLU230H, GLU278H, GLU76L, GLU87L, GLY157L, GLY19L, GLY216L, GLY219L, GLY245H, GLY246H, GLY262H, GLY268H, GLY289H, GLY296H, GLY303H, GLY304H, GLY43L, GLY45L, GLY46L, GLY89L, HIS20L, HIS221H, HIS221L, HIS263H, HIS299H, HIS353H, ILE154L, ILE256H, ILE351H, ILE47L, ILE77L, ILE88L, LEU104L, LEU217L, LEU264H, LEU265H, LEU266H, LEU273H, LEU274H, LEU300H, LEU44L, LYS146L, LYS226L, LYS270H, LYS290H, LYS301H, LYS301L, LYS352H, LYS78L, MET269H, MET67L, MET73L, PHE227L, PHE258H, PHE272H, PRO156L, PRO229H, PRO23L, PRO261H, PRO267H, PRO306H, SER18L, SER223L, SER307H, SER75L, THR105L, THR159L, THR222L, THR224L, THR225H, THR225L, THR275H, THR41L, TYR259H, TYR284H, TYR286H, TYR287H, TYR354H, VAL17L, VAL211L, VAL215L, VAL305H, VAL39L, VAL40L, VAL74L, VAL85L, VAL86L
• I-J: ALA135I, ALA220I, ALA22I, ALA26I, ALA295J, ALA297I, ALA297J, ALA298J, ARG106I, ARG155I, ARG218I, ARG25I, ARG29I, ARG84I, ASN302I, ASN302J, ASP158I, ASP260J, ASP271J, ASP42I, ASP68I, CYS288J, GLN212I, GLN247J, GLN285J, GLU150I, GLU214I, GLU21I, GLU230J, GLU278J, GLU76I, GLU87I, GLY157I, GLY19I, GLY216I, GLY219I, GLY245J, GLY246J, GLY262J, GLY268J, GLY289J, GLY296J, GLY303J, GLY304J, GLY43I, GLY45I, GLY46I, GLY89I, HIS20I, HIS221I, HIS221J, HIS263J, HIS299J, HIS353J, ILE154I, ILE256J, ILE351J, ILE47I, ILE77I, ILE88I, LEU104I, LEU217I, LEU264J, LEU265J, LEU266J, LEU273J, LEU274J, LEU300J, LEU44I, LYS146I, LYS226I, LYS270J, LYS290J, LYS301I, LYS301J, LYS352J, LYS78I, MET269J, MET67I, MET73I, PHE227I, PHE258J, PHE272J, PRO156I, PRO23I, PRO261J, PRO267J, PRO306J, SER18I, SER223I, SER307J, SER75I, THR105I, THR159I, THR222I, THR224I, THR225I, THR225J, THR275J, THR41I, TYR259J, TYR284J, TYR286J, TYR287J, TYR354J, VAL17I, VAL211I, VAL215I, VAL231J, VAL305J, VAL40I, VAL74I, VAL85I, VAL86I
• I-K: ALA135K, ALA220K, ALA22K, ALA26K, ALA295I, ALA297I, ALA297K, ALA298I, ARG106K, ARG155K, ARG218K, ARG25K, ARG29K, ARG84K, ASN302I, ASN302K, ASP158K, ASP228K, ASP260I, ASP271I, ASP42K, ASP68K, CYS288I, GLN212K, GLN247I, GLN285I, GLU150K, GLU214K, GLU21K, GLU230I, GLU278I, GLU76K, GLU87K, GLY157K, GLY19K, GLY216K, GLY219K, GLY245I, GLY246I, GLY262I, GLY268I, GLY289I, GLY296I, GLY303I, GLY304I, GLY43K, GLY45K, GLY46K, GLY89K, HIS20K, HIS221I, HIS221K, HIS263I, HIS299I, HIS353I, ILE256I, ILE351I, ILE47K, ILE77K, ILE88K, LEU104K, LEU217K, LEU264I, LEU265I, LEU266I, LEU273I, LEU274I, LEU300I, LEU44K, LYS146K, LYS226K, LYS270I, LYS290I, LYS301I, LYS301K, LYS352I, LYS78K, MET269I, MET67K, MET73K, PHE227K, PHE258I, PHE272I, PRO156K, PRO229I, PRO23K, PRO261I, PRO267I, PRO306I, SER18K, SER223K, SER307I, SER75K, THR105K, THR159K, THR222K, THR224K, THR225I, THR225K, THR275I, THR41K, TYR259I, TYR284I, TYR286I, TYR287I, TYR354I, VAL17K, VAL211K, VAL215K, VAL231I, VAL305I, VAL39K, VAL40K, VAL74K, VAL85K, VAL86K
• I-L: ALA133I, ALA133L, ALA144I, ALA144L, ALA149I, ALA149L, ALA166I, ALA166L, ALA170I, ALA170L, ARG100I, ARG100L, ARG315I, ARG315L, ARG84I, ARG84L, ASN171I, ASN171L, ASN174I, ASN174L, ASN92I, ASN92L, ASP136I, ASP136L, ASP140I, ASP140L, ASP145I, ASP145L, ASP163I, ASP163L, ASP242I, ASP242L, ASP80I, ASP80L, GLN321I, GLN321L, GLN99I, GLN99L, GLU110I, GLU110L, GLU13I, GLU13L, GLU148I, GLU148L, GLU172I, GLU172L, GLY116I, GLY116L, GLY141I, GLY141L, GLY142I, GLY142L, GLY245I, GLY245L, GLY251L, GLY81I, GLY81L, HIS109I, HIS109L, HIS318I, HIS318L, HIS320I, HIS320L, ILE111I, ILE111L, ILE114I, ILE114L, ILE137I, ILE137L, ILE154I, ILE154L, ILE167I, ILE167L, ILE175I, ILE175L, ILE176I, ILE176L, ILE250I, ILE250L, ILE317I, ILE317L, LEU103I, LEU103L, LEU168I, LEU168L, LEU323I, LEU323L, LYS102I, LYS102L, LYS173I, LYS173L, LYS178I, LYS178L, LYS249I, LYS249L, LYS78I, LYS78L, LYS9I, LYS9L, MET94I, MET94L, PHE101I, PHE101L, PHE139I, PHE139L, PHE143I, PHE143L, PHE152I, PHE152L, PHE5I, PHE83I, PHE83L, PRO112I, PRO112L, PRO132I, PRO132L, PRO93I, PRO93L, SER115I, SER115L, SER151I, SER151L, SER164I, SER164L, SER165I, SER165L, SER177I, SER177L, SER319I, SER319L, SER97I, SER97L, SER98I, SER98L, THR169I, THR169L, THR322I, THR322L, THR82I, THR82L, TRP91I, TRP91L, TYR244I, TYR244L, TYR316I, TYR316L, TYR324I, TYR324L, VAL113I, VAL113L, VAL138I, VAL138L, VAL243I, VAL243L, VAL95I, VAL95L, VAL96I, VAL96L
• J-K: ALA135J, ALA220J, ALA22J, ALA26J, ALA297J, ALA297K, ALA298K, ARG106J, ARG155J, ARG218J, ARG257K, ARG25J, ARG29J, ARG84J, ASN302J, ASN302K, ASP158J, ASP260K, ASP271K, ASP42J, ASP68J, CYS288K, GLN212J, GLN247K, GLN285K, GLU150J, GLU214J, GLU21J, GLU230K, GLU278K, GLU76J, GLU87J, GLY153J, GLY157J, GLY19J, GLY216J, GLY219J, GLY245K, GLY246K, GLY262K, GLY268K, GLY289K, GLY296K, GLY303K, GLY304K, GLY43J, GLY45J, GLY46J, GLY89J, HIS20J, HIS221J, HIS221K, HIS263K, HIS299K, HIS353K, ILE154J, ILE256K, ILE351K, ILE47J, ILE77J, ILE88J, LEU104J, LEU217J, LEU264K, LEU265K, LEU266K, LEU273K, LEU274K, LEU300K, LEU44J, LYS146J, LYS226J, LYS270K, LYS290K, LYS301J, LYS301K, LYS352K, LYS78J, MET269K, MET67J, MET73J, PHE227J, PHE258K, PHE272K, PRO156J, PRO23J, PRO261K, PRO267K, PRO306K, SER18J, SER223J, SER307K, SER75J, THR105J, THR159J, THR222J, THR224J, THR225J, THR225K, THR275K, THR276K, THR41J, TYR259K, TYR284K, TYR286K, TYR287K, TYR354K, VAL17J, VAL211J, VAL215J, VAL231K, VAL305K, VAL40J, VAL74J, VAL85J, VAL86J