3KIC

crystal structure of adeno-associated virus serotype 3b

• Total interactions analyzed: 190
• Total true interactions: 51
• Strongest Interaction:
  • Chains: C-D
  • Int. Res.: 342
  • Norm. En. per Res.: -6.0136
• Hub Node: A(9)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-85.6648	-205.6947	-410.691	-702.0505	142	40	2	15888	13	36	32
A-C	-375.0683	-28.6339	-1582.87	-1986.5722	342	158	30	59358	4	66	63
A-D	-384.7479	-29.3212	-1598.76	-2012.829	342	154	29	59143	4	66	63
A-E	-87.3795	-9.6622	-654.477	-751.5187	213	41	12	26479	1	16	17
A-F	0.0	0.0	-0.0074	-0.0074	5	0	0	8	0	0	0
A-G	0.0	0.0	-0.0101	-0.0101	6	0	0	10	0	0	0
A-H	-68.508	-10.9629	-663.436	-742.907	215	45	12	26699	1	16	17
A-I	0.0	0.0	-8.6086	-8.6086	11	1	2	460	0	0	0
A-J	0.0	0.0	-9.0129	-9.0129	11	1	2	462	0	0	0
B-C	-81.766	-8.0378	-671.31	-761.1139	214	39	12	26603	1	16	17
B-G	0.0	0.0	-8.5514	-8.5514	12	1	2	481	0	0	0
B-H	-354.5727	-37.4876	-1588.43	-1980.4903	343	150	30	59350	4	66	63
B-J	0.0	0.0	-0.0041	-0.0041	6	0	0	7	0	0	0
B-M	0.0	0.0	-0.0104	-0.0104	6	0	0	11	0	0	0
B-N	-96.4035	-7.9798			22
C-D	-374.8806	-39.4951	-1642.28	-2056.6557	342	164	27	59697	4	66	64
C-J	-69.3089	-8.2009	-639.578	-717.0879	214	35	12	26095	1	16	17
C-M	0.0	0.0	-0.0042	-0.0042	6	0	0	7	0	0	0
C-O	-85.2337	-204.8531			28
D-E	-80.4144	-202.7004	-418.512	-701.6268	140	34	2	15825	14	36	32
D-H	0.0	0.0	-8.7394	-8.7394	12	1	2	492	0	0	0
D-K	0.0	0.0	-0.0077	-0.0077	6	0	0	9	0	0	0
D-O	-87.8709	-8.4393			22
D-Q	-74.9705	-10.12			20
E-F	-91.5313	-8.2717	-653.18	-752.983	212	37	12	26121	1	16	17
E-G	0.0	0.0	-0.0099	-0.0099	6	0	0	10	0	0	0
E-H	0.0	0.0	-0.0106	-0.0106	6	0	0	11	0	0	0
E-I	-378.3772	-30.0496	-1597.56	-2005.9868	343	144	28	59004	4	66	63
E-K	0.0	0.0	-8.6325	-8.6325	11	1	2	446	0	0	0
E-Q	-356.7259	-28.5543			90
F-G	-83.5536	-8.8651	-640.496	-732.9147	213	29	12	26020	1	16	17
F-H	0.0	0.0	-0.0038	-0.0038	5	0	0	6	0	0	0
F-I	-89.1251	-205.0507	-419.829	-714.0048	140	35	2	15936	14	36	32
F-L	0.0	0.0	-8.4371	-8.4371	12	1	2	483	0	0	0
F-P	-363.4675	-29.3701			86
G-H	-100.7672	-9.2178	-647.561	-757.546	213	36	12	26121	1	16	17
I-L	0.0	0.0	-0.0104	-0.0104	6	0	0	11	0	0	0
I-P	-85.0532	-8.4601			21
I-Q	-377.9794	-28.6176			88
I-R	-89.9431	-10.2815			20
J-M	-68.4622	-8.6792	-457.745	-534.8864	159	35	7	17689	0	11	13
J-O	-397.2663	-39.1816			98
K-Q	-84.9559	-7.8158			21
K-R	-389.6169	-27.3623			93
K-S	-74.2406	-9.7993			21
L-P	-97.2164	-9.4174			22
L-T	-79.7654	-8.6887			20
M-N	-74.3567	-10.1986			19
O-S	-80.1556	-11.0556			20
Q-R	-83.5604	-207.5579			28
R-T	-97.8906	-9.8362			24

Interface residues

• A-B: ALA367A, ALA367B, ARG245A, ARG245B, ARG294A, ARG294B, ARG298A, ARG298B, ARG567A, ARG567B, ARG694A, ARG694B, ARG725A, ARG725B, ASN301A, ASN301B, ASN302A, ASN302B, ASN303A, ASN303B, ASN691A, ASN691B, ASN696A, ASN696B, ASN704A, ASN704B, ASN706A, ASN706B, ASP231A, ASP231B, ASP295A, ASP295B, ASP529A, ASP529B, ASP530A, ASP530B, ASP562A, ASP562B, ASP712A, ASP712B, CYS230A, CYS230B, CYS289A, CYS289B, GLN233A, GLN233B, GLN297A, GLN297B, GLN700A, GLN700B, GLU531A, GLU531B, GLU532A, GLU532B, GLU564A, GLU564B, GLU565A, GLU565B, GLU690A, GLU690B, GLU698A, GLU698B, GLU723A, GLU723B, GLY236A, GLY236B, HIS288A, HIS288B, HIS290A, HIS290B, HIS527A, HIS527B, ILE699A, ILE699B, ILE727A, ILE727B, LEU235A, LEU235B, LEU614A, LEU614B, LEU732A, LEU732B, LYS689A, LYS689B, LYS693A, LYS693B, LYS707A, LYS707B, PHE291A, PHE291B, PHE365A, PHE365B, PHE713A, PHE713B, PRO293A, PRO293B, PRO363A, PRO363B, PRO364A, PRO364B, PRO366A, PRO366B, PRO697A, PRO697B, PRO724A, PRO724B, SER232A, SER232B, SER243A, SER243B, SER292A, SER292B, SER692A, SER692B, SER703A, SER703B, THR702A, THR702B, THR714A, THR714B, THR733A, THR733B, TRP234A, TRP234B, TRP296A, TRP296B, TRP304A, TRP304B, TRP695A, TRP695B, TYR701A, TYR701B, TYR705A, TYR705B, TYR721A, TYR721B, TYR731A, TYR731B, VAL711A, VAL711B, VAL715A, VAL715B
• A-C: ALA357C, ALA386C, ALA425A, ALA466A, ALA475A, ALA493C, ALA505C, ALA506C, ALA523A, ALA523C, ALA525A, ALA550C, ALA553C, ALA573A, ALA573C, ALA581A, ALA590A, ALA601A, ALA601C, ALA620C, ARG286C, ARG389C, ARG432A, ARG447A, ARG460A, ARG476A, ARG485A, ARG485C, ARG488C, ARG514C, ARG567A, ARG594A, ARG594C, ARG610A, ARG610C, ARG694A, ARG730A, ARG734A, ASN253C, ASN268C, ASN270C, ASN285C, ASN381C, ASN382C, ASN435A, ASN446A, ASN457A, ASN477A, ASN494C, ASN496C, ASN497C, ASN498C, ASN500C, ASN512C, ASN519C, ASN540C, ASN552C, ASN557C, ASN570A, ASN570C, ASN582A, ASN583A, ASN588A, ASN597A, ASN597C, ASN691A, ASN696A, ASN735A, ASP269C, ASP283C, ASP345C, ASP431A, ASP439A, ASP495C, ASP515C, ASP529A, ASP530A, ASP556C, ASP562A, ASP598A, ASP598C, ASP609A, ASP609C, ASP611A, ASP626C, CYS361C, CYS394C, CYS483C, GLN263C, GLN349C, GLN359C, GLN374C, GLN385C, GLN428A, GLN440A, GLN449A, GLN458A, GLN465A, GLN469A, GLN474A, GLN486C, GLN487C, GLN576A, GLN576C, GLN585A, GLN599A, GLN599C, GLN608A, GLN608C, GLN615C, GLN646C, GLN688A, GLN700A, GLU347C, GLU396C, GLU531A, GLU531C, GLU554C, GLU564A, GLU565A, GLU575A, GLU575C, GLU690A, GLU698A, GLY274C, GLY280C, GLY305A, GLY355C, GLY360C, GLY376C, GLY383C, GLY388C, GLY450A, GLY467A, GLY481A, GLY481C, GLY513C, GLY521C, GLY539C, GLY544C, GLY547C, GLY578A, GLY600A, GLY600C, GLY604A, GLY616C, GLY627A, GLY627C, GLY636C, GLY637C, GLY639C, GLY728A, HIS271C, HIS288C, HIS358C, HIS421A, HIS426A, HIS510A, HIS510C, HIS527A, HIS538C, HIS624C, HIS628A, HIS628C, HIS630A, HIS630C, HIS642C, ILE260C, ILE438A, ILE542C, ILE560C, ILE566A, ILE618C, ILE622C, ILE699A, LEU350C, LEU354C, LEU378C, LEU380C, LEU395C, LEU430A, LEU433A, LEU437A, LEU442A, LEU445A, LEU461A, LEU462A, LEU473A, LEU479A, LEU489C, LEU511C, LEU517C, LEU541C, LEU555C, LEU584A, LEU584C, LEU602A, LEU602C, LEU634C, LEU640C, LEU732A, LEU736A, LYS258C, LYS491C, LYS508C, LYS528A, LYS528C, LYS533C, LYS545C, LYS621C, LYS693A, MET434A, MET471A, MET524C, MET537C, MET559C, MET605A, MET605C, MET635C, PHE273C, PHE287C, PHE343C, PHE392C, PHE398C, PHE420A, PHE463A, PHE501C, PHE534C, PHE535C, PHE543C, PHE629A, PHE629C, PHE638C, PRO278C, PRO351C, PRO373C, PRO399C, PRO419A, PRO436A, PRO468A, PRO480A, PRO482A, PRO482C, PRO502C, PRO520C, PRO522C, PRO536C, PRO571A, PRO591A, PRO603A, PRO603C, PRO617C, PRO623C, PRO631C, PRO633C, PRO643C, PRO697A, SER261C, SER262C, SER267C, SER276C, SER356C, SER390C, SER391C, SER422A, SER423A, SER427A, SER429A, SER459A, SER464A, SER470A, SER472A, SER490C, SER499C, SER507C, SER516C, SER551C, SER586A, SER587A, SER632A, SER632C, SER692A, THR277C, THR379C, THR448A, THR451A, THR492C, THR504C, THR548C, THR549C, THR561C, THR568A, THR569A, THR574A, THR574C, THR579A, THR589A, THR592A, THR593A, THR595A, THR595C, THR625C, THR729A, THR733A, TRP279C, TRP304A, TRP478A, TRP503C, TRP607A, TRP607C, TRP619C, TRP695A, TYR252C, TYR272C, TYR275C, TYR281C, TYR348C, TYR352C, TYR375C, TYR377C, TYR393C, TYR397C, TYR424A, TYR441A, TYR443A, TYR444A, TYR484C, TYR509C, TYR577A, TYR613C, TYR731A, VAL353C, VAL372C, VAL387C, VAL518C, VAL558C, VAL572A, VAL572C, VAL580A, VAL596A, VAL596C, VAL606A
• A-D: ALA357A, ALA386A, ALA425D, ALA466D, ALA475D, ALA493A, ALA505A, ALA506A, ALA523A, ALA523D, ALA525D, ALA550A, ALA553A, ALA573A, ALA573D, ALA581D, ALA590D, ALA601A, ALA601D, ALA620A, ARG286A, ARG389A, ARG432D, ARG447D, ARG460D, ARG476D, ARG485A, ARG485D, ARG488A, ARG514A, ARG567D, ARG594A, ARG594D, ARG610A, ARG610D, ARG694D, ARG730D, ARG734D, ASN253A, ASN268A, ASN270A, ASN285A, ASN381A, ASN382A, ASN435D, ASN446D, ASN457D, ASN477D, ASN494A, ASN496A, ASN497A, ASN498A, ASN500A, ASN512A, ASN519A, ASN540A, ASN552A, ASN557A, ASN570A, ASN570D, ASN582D, ASN583D, ASN588D, ASN597A, ASN597D, ASN691D, ASN696D, ASN735D, ASP269A, ASP283A, ASP345A, ASP431D, ASP439D, ASP495A, ASP515A, ASP529D, ASP530D, ASP556A, ASP562D, ASP598A, ASP598D, ASP609A, ASP609D, ASP611D, ASP626A, CYS361A, CYS394A, CYS483A, GLN263A, GLN349A, GLN359A, GLN374A, GLN385A, GLN428D, GLN440D, GLN449D, GLN458D, GLN465D, GLN469D, GLN474D, GLN486A, GLN487A, GLN576A, GLN576D, GLN585D, GLN599A, GLN599D, GLN608A, GLN608D, GLN615A, GLN646A, GLN688D, GLN700D, GLU347A, GLU396A, GLU531A, GLU531D, GLU554A, GLU564D, GLU565D, GLU575A, GLU575D, GLU690D, GLU698D, GLY274A, GLY280A, GLY305D, GLY355A, GLY360A, GLY376A, GLY383A, GLY388A, GLY450D, GLY467D, GLY481A, GLY481D, GLY513A, GLY521A, GLY539A, GLY544A, GLY547A, GLY578D, GLY600A, GLY600D, GLY604D, GLY616A, GLY627A, GLY627D, GLY636A, GLY637A, GLY639A, GLY728D, HIS271A, HIS288A, HIS358A, HIS421D, HIS426D, HIS510A, HIS510D, HIS527D, HIS538A, HIS624A, HIS628A, HIS628D, HIS630A, HIS630D, HIS642A, ILE260A, ILE438D, ILE542A, ILE560A, ILE566D, ILE618A, ILE622A, ILE699D, LEU350A, LEU354A, LEU378A, LEU380A, LEU395A, LEU430D, LEU433D, LEU437D, LEU442D, LEU445D, LEU461D, LEU462D, LEU473D, LEU479D, LEU489A, LEU511A, LEU517A, LEU541A, LEU555A, LEU584A, LEU584D, LEU602A, LEU602D, LEU634A, LEU640A, LEU732D, LEU736D, LYS258A, LYS491A, LYS508A, LYS528A, LYS528D, LYS533A, LYS545A, LYS621A, LYS693D, MET434D, MET471D, MET524A, MET537A, MET559A, MET605A, MET605D, MET635A, PHE273A, PHE287A, PHE343A, PHE392A, PHE398A, PHE420D, PHE463D, PHE501A, PHE534A, PHE535A, PHE543A, PHE629A, PHE629D, PHE638A, PRO278A, PRO351A, PRO373A, PRO399A, PRO419D, PRO436D, PRO468D, PRO480D, PRO482A, PRO482D, PRO502A, PRO520A, PRO522A, PRO536A, PRO571D, PRO591D, PRO603A, PRO603D, PRO617A, PRO623A, PRO631A, PRO633A, PRO643A, PRO697D, SER261A, SER262A, SER267A, SER276A, SER356A, SER390A, SER391A, SER422D, SER423D, SER427D, SER429D, SER459D, SER464D, SER470D, SER472D, SER490A, SER499A, SER507A, SER516A, SER551A, SER586D, SER587D, SER632A, SER632D, SER692D, THR277A, THR379A, THR448D, THR451D, THR492A, THR504A, THR548A, THR549A, THR561A, THR568D, THR569D, THR574A, THR574D, THR579D, THR589D, THR592D, THR593D, THR595A, THR595D, THR625A, THR729D, THR733D, TRP279A, TRP304D, TRP478D, TRP503A, TRP607A, TRP607D, TRP619A, TRP695D, TYR252A, TYR272A, TYR275A, TYR281A, TYR348A, TYR352A, TYR375A, TYR377A, TYR393A, TYR397A, TYR424D, TYR441D, TYR443D, TYR444D, TYR484A, TYR509A, TYR577D, TYR613A, TYR731D, VAL353A, VAL372A, VAL387A, VAL518A, VAL558A, VAL572A, VAL572D, VAL580D, VAL596A, VAL596D, VAL606D
• A-E: ALA218A, ALA248E, ALA333A, ALA333E, ALA367E, ALA386A, ALA550E, ALA656A, ALA665A, ALA668A, ARG245E, ARG294E, ARG298E, ARG389A, ARG404A, ARG404E, ASN223A, ASN223E, ASN227E, ASN253A, ASN253E, ASN254A, ASN254E, ASN317E, ASN326A, ASN334A, ASN334E, ASN335A, ASN335E, ASN381A, ASN382A, ASN407A, ASN407E, ASN408A, ASN408E, ASN651E, ASN657A, ASN704E, ASN706E, ASN710E, ASN718E, ASP219A, ASP219E, ASP231E, ASP295E, ASP327A, ASP327E, ASP368E, ASP712E, ASP716E, CYS230E, CYS289E, CYS361E, CYS394A, GLN233E, GLN259A, GLN319E, GLN325A, GLN325E, GLN341A, GLN349A, GLN359E, GLN374E, GLN385A, GLN401A, GLN673A, GLN673E, GLN678E, GLU322A, GLU322E, GLU396A, GLU546E, GLY217A, GLY220A, GLY220E, GLY222A, GLY222E, GLY226E, GLY274A, GLY328E, GLY360E, GLY383A, GLY388A, GLY406A, GLY406E, GLY547E, GLY677E, GLY719E, HIS229E, HIS255A, HIS255E, HIS290E, HIS358E, ILE240E, ILE260A, ILE318E, ILE332E, ILE671A, LEU249E, LEU256A, LEU336A, LEU336E, LEU380A, LEU395A, LEU403A, LYS258A, LYS258E, LYS321E, LYS650A, LYS666A, LYS707E, MET371E, MET402A, PHE273A, PHE291E, PHE316E, PHE343A, PHE365E, PHE370E, PHE392A, PHE398A, PHE662A, PHE667A, PHE670A, PHE713E, PRO250E, PRO278A, PRO278E, PRO293E, PRO363E, PRO364E, PRO366E, PRO373E, PRO399A, PRO653A, PRO655A, PRO658A, PRO659A, PRO664A, SER224E, SER225E, SER232E, SER243E, SER261A, SER276A, SER292E, SER338A, SER384A, SER390A, SER391A, SER400A, SER663A, SER669A, SER675E, SER703E, SER708E, SER722E, THR241E, THR242E, THR244E, THR246E, THR251E, THR277A, THR324A, THR324E, THR329E, THR330E, THR331A, THR331E, THR337A, THR339A, THR379A, THR405A, THR405E, THR652A, THR660A, THR661A, THR672A, THR672E, THR676E, THR714E, THR717E, TRP228E, TRP234E, TRP247E, TRP279A, TRP296E, TYR252E, TYR257A, TYR275A, TYR281E, TYR377A, TYR393A, TYR397A, TYR674E, TYR705E, TYR721E, VAL221A, VAL221E, VAL239E, VAL320A, VAL320E, VAL323E, VAL340A, VAL342A, VAL369E, VAL372E, VAL387A, VAL654A, VAL709E, VAL711E, VAL715E, VAL720E
• A-F: ARG404A, GLY222F, LEU336A, LEU336F, THR337A
• A-G: ARG404G, GLY222A, LEU336A, LEU336G, THR337G, VAL221A
• A-H: ALA218H, ALA248A, ALA333A, ALA333H, ALA367A, ALA386H, ALA550A, ALA656H, ALA665H, ALA668H, ARG245A, ARG294A, ARG298A, ARG389H, ARG404A, ARG404H, ASN223A, ASN223H, ASN227A, ASN253A, ASN253H, ASN254A, ASN254H, ASN317A, ASN326A, ASN326H, ASN334A, ASN334H, ASN335A, ASN335H, ASN381H, ASN382H, ASN407A, ASN407H, ASN408A, ASN408H, ASN651A, ASN657H, ASN704A, ASN706A, ASN710A, ASN718A, ASP219A, ASP219H, ASP231A, ASP295A, ASP327A, ASP327H, ASP368A, ASP712A, ASP716A, CYS230A, CYS289A, CYS361A, CYS394H, GLN233A, GLN259H, GLN319A, GLN325A, GLN325H, GLN341H, GLN349H, GLN359A, GLN374A, GLN385H, GLN401H, GLN673A, GLN673H, GLN678A, GLU322A, GLU322H, GLU396H, GLU546A, GLY217H, GLY220A, GLY220H, GLY222A, GLY222H, GLY226A, GLY274H, GLY328A, GLY360A, GLY383H, GLY388H, GLY406A, GLY406H, GLY547A, GLY677A, GLY719A, HIS229A, HIS255A, HIS255H, HIS290A, HIS358A, ILE240A, ILE260H, ILE318A, ILE332A, ILE671H, LEU249A, LEU256H, LEU336A, LEU336H, LEU380H, LEU395H, LEU403H, LYS258A, LYS258H, LYS321A, LYS650H, LYS666H, LYS707A, MET371A, MET402H, PHE273H, PHE291A, PHE316A, PHE343H, PHE365A, PHE370A, PHE392H, PHE398H, PHE662H, PHE667H, PHE670H, PHE713A, PRO250A, PRO278A, PRO278H, PRO293A, PRO363A, PRO364A, PRO366A, PRO373A, PRO399H, PRO653H, PRO655H, PRO658H, PRO659H, PRO664H, SER224A, SER225A, SER232A, SER243A, SER261H, SER276H, SER292A, SER338H, SER384H, SER390H, SER391H, SER400H, SER663H, SER669H, SER675A, SER703A, SER708A, SER722A, THR241A, THR242A, THR244A, THR246A, THR251A, THR277H, THR324A, THR324H, THR329A, THR330A, THR331A, THR331H, THR337H, THR339H, THR379H, THR405A, THR405H, THR652H, THR660H, THR661H, THR672A, THR672H, THR676A, THR702A, THR714A, THR717A, TRP228A, TRP234A, TRP247A, TRP279H, TRP296A, TYR252A, TYR257H, TYR275H, TYR281A, TYR377H, TYR393H, TYR397H, TYR674A, TYR705A, TYR721A, VAL221A, VAL221H, VAL239A, VAL320A, VAL320H, VAL323A, VAL340H, VAL342H, VAL369A, VAL372A, VAL387H, VAL654H, VAL709A, VAL711A, VAL715A, VAL720A
• A-I: ASN435I, ASP439I, GLN440I, GLN465I, ILE438I, LEU437I, PHE662A, PRO664A, SER663A, THR661A, TYR441I
• A-J: ASN435A, ASP439A, GLN440A, GLN465A, ILE438A, LEU437A, PHE662J, PRO664J, SER663J, THR661J, TYR441A
• B-C: ALA218C, ALA248B, ALA333B, ALA333C, ALA367B, ALA386C, ALA550B, ALA656C, ALA665C, ALA668C, ARG245B, ARG294B, ARG298B, ARG389C, ARG404B, ARG404C, ASN223B, ASN223C, ASN227B, ASN253B, ASN253C, ASN254B, ASN254C, ASN317B, ASN326B, ASN326C, ASN334B, ASN334C, ASN335B, ASN335C, ASN381C, ASN382C, ASN407B, ASN407C, ASN408B, ASN408C, ASN651B, ASN657C, ASN704B, ASN706B, ASN710B, ASN718B, ASP219B, ASP219C, ASP231B, ASP295B, ASP327B, ASP327C, ASP368B, ASP712B, ASP716B, CYS230B, CYS289B, CYS361B, CYS394C, GLN233B, GLN259C, GLN319B, GLN325B, GLN325C, GLN341C, GLN349C, GLN359B, GLN374B, GLN385C, GLN401C, GLN673B, GLN673C, GLN678B, GLU322B, GLU322C, GLU396C, GLU546B, GLY217C, GLY220B, GLY220C, GLY222B, GLY222C, GLY226B, GLY274C, GLY328B, GLY360B, GLY383C, GLY388C, GLY406B, GLY406C, GLY547B, GLY677B, GLY719B, HIS229B, HIS255B, HIS255C, HIS290B, HIS358B, ILE240B, ILE260C, ILE318B, ILE332B, ILE671C, LEU249B, LEU256C, LEU336B, LEU336C, LEU380C, LEU395C, LEU403C, LYS258B, LYS258C, LYS321B, LYS650C, LYS666C, LYS707B, MET371B, MET402C, PHE273C, PHE291B, PHE316B, PHE343C, PHE365B, PHE370B, PHE392C, PHE398C, PHE662C, PHE667C, PHE670C, PHE713B, PRO250B, PRO278B, PRO278C, PRO293B, PRO363B, PRO364B, PRO366B, PRO373B, PRO399C, PRO653C, PRO655C, PRO658C, PRO659C, PRO664C, SER224B, SER225B, SER232B, SER243B, SER261C, SER276C, SER292B, SER338C, SER384C, SER390C, SER391C, SER400C, SER663C, SER669C, SER675B, SER703B, SER708B, SER722B, THR241B, THR242B, THR244B, THR246B, THR251B, THR277C, THR324B, THR324C, THR329B, THR330B, THR331B, THR331C, THR337C, THR339C, THR379C, THR405B, THR405C, THR652C, THR660C, THR661C, THR672B, THR672C, THR676B, THR702B, THR714B, THR717B, TRP228B, TRP234B, TRP247B, TRP279C, TRP296B, TYR252B, TYR257C, TYR275C, TYR281B, TYR377C, TYR393C, TYR397C, TYR674B, TYR705B, TYR721B, VAL221B, VAL221C, VAL320B, VAL320C, VAL323B, VAL340C, VAL342C, VAL369B, VAL372B, VAL387C, VAL654C, VAL709B, VAL711B, VAL715B, VAL720B
• B-G: ASN435B, ASP439B, GLN440B, GLN465B, ILE438B, LEU437B, PHE662G, PRO664G, SER663G, THR660G, THR661G, TYR441B
• B-H: ALA357H, ALA386H, ALA425B, ALA466B, ALA475B, ALA493H, ALA505H, ALA506H, ALA523B, ALA523H, ALA525B, ALA550H, ALA553H, ALA573B, ALA573H, ALA581B, ALA590B, ALA601B, ALA601H, ALA620H, ARG286H, ARG389H, ARG432B, ARG447B, ARG460B, ARG476B, ARG485B, ARG485H, ARG488H, ARG514H, ARG567B, ARG594B, ARG594H, ARG610B, ARG610H, ARG694B, ARG730B, ARG734B, ASN253H, ASN268H, ASN270H, ASN285H, ASN381H, ASN382H, ASN435B, ASN446B, ASN457B, ASN477B, ASN494H, ASN496H, ASN497H, ASN498H, ASN500H, ASN512H, ASN519H, ASN540H, ASN552H, ASN557H, ASN570B, ASN570H, ASN582B, ASN583B, ASN588B, ASN597B, ASN597H, ASN691B, ASN696B, ASN735B, ASP269H, ASP283H, ASP345H, ASP431B, ASP439B, ASP495H, ASP515H, ASP529B, ASP530B, ASP556H, ASP562B, ASP598B, ASP598H, ASP609B, ASP609H, ASP611B, ASP626H, CYS361H, CYS394H, CYS483B, CYS483H, GLN263H, GLN349H, GLN359H, GLN374H, GLN385H, GLN428B, GLN440B, GLN449B, GLN458B, GLN465B, GLN469B, GLN474B, GLN486H, GLN487H, GLN576B, GLN576H, GLN585B, GLN599B, GLN599H, GLN608B, GLN608H, GLN615H, GLN646H, GLN688B, GLN700B, GLU347H, GLU396H, GLU531B, GLU531H, GLU546H, GLU554H, GLU563B, GLU564B, GLU565B, GLU575B, GLU575H, GLU690B, GLU698B, GLY274H, GLY280H, GLY305B, GLY355H, GLY360H, GLY376H, GLY383H, GLY388H, GLY450B, GLY467B, GLY481B, GLY481H, GLY513H, GLY521H, GLY539H, GLY544H, GLY547H, GLY578B, GLY600B, GLY600H, GLY604B, GLY616H, GLY627B, GLY627H, GLY636H, GLY637H, GLY639H, GLY728B, HIS271H, HIS288H, HIS358H, HIS421B, HIS426B, HIS510H, HIS527B, HIS538H, HIS624H, HIS628B, HIS628H, HIS630B, HIS630H, HIS642H, ILE260H, ILE438B, ILE542H, ILE560H, ILE566B, ILE618H, ILE622H, ILE699B, LEU350H, LEU354H, LEU378H, LEU380H, LEU395H, LEU430B, LEU433B, LEU437B, LEU442B, LEU445B, LEU461B, LEU462B, LEU473B, LEU479B, LEU489H, LEU511H, LEU517H, LEU541H, LEU555H, LEU584B, LEU602B, LEU602H, LEU634H, LEU640H, LEU732B, LEU736B, LYS258H, LYS491H, LYS508H, LYS528B, LYS528H, LYS533H, LYS545H, LYS621H, LYS693B, MET434B, MET471B, MET524H, MET537H, MET559H, MET605B, MET605H, MET635H, PHE273H, PHE287H, PHE343H, PHE392H, PHE398H, PHE420B, PHE463B, PHE501H, PHE534H, PHE535H, PHE543H, PHE629B, PHE629H, PHE638H, PRO278H, PRO351H, PRO373H, PRO399H, PRO419B, PRO436B, PRO468B, PRO480B, PRO482B, PRO482H, PRO502H, PRO520H, PRO522H, PRO536H, PRO571B, PRO591B, PRO603B, PRO603H, PRO617H, PRO623H, PRO631H, PRO633H, PRO643H, PRO697B, SER261H, SER262H, SER267H, SER276H, SER356H, SER390H, SER391H, SER422B, SER423B, SER427B, SER429B, SER459B, SER464B, SER470B, SER472B, SER490H, SER499H, SER507H, SER516H, SER551H, SER586B, SER587B, SER632B, SER632H, SER692B, THR277H, THR379H, THR448B, THR451B, THR492H, THR504H, THR548H, THR549H, THR561H, THR568B, THR569B, THR574B, THR574H, THR579B, THR589B, THR592B, THR593B, THR595B, THR595H, THR625H, THR729B, THR733B, TRP279H, TRP304B, TRP478B, TRP503H, TRP607B, TRP607H, TRP619H, TRP695B, TYR252H, TYR272H, TYR275H, TYR281H, TYR348H, TYR352H, TYR375H, TYR377H, TYR393H, TYR397H, TYR424B, TYR441B, TYR443B, TYR444B, TYR484H, TYR509H, TYR577B, TYR613H, TYR731B, VAL353H, VAL372H, VAL387H, VAL518H, VAL558H, VAL572B, VAL572H, VAL580B, VAL596B, VAL596H, VAL606B
• B-J: ARG404J, GLY222B, LEU336B, LEU336J, THR337J, VAL221B
• B-M: ARG404B, GLY222M, LEU336B, LEU336M, THR337B, VAL221M
• B-N: ALA386B, ARG245N, ARG404B, ASN407B, ASP219N, ASP295N, ASP327B, ASP327N, ASP368N, ASP716N, GLN259B, GLN319N, GLU396B, GLU546N, LYS258B, LYS666B, SER224N, SER400B, SER708N, THR337B, TRP228N, TYR397B
• C-D: ALA357D, ALA425C, ALA466C, ALA475C, ALA493D, ALA505D, ALA506D, ALA523C, ALA523D, ALA525C, ALA550D, ALA553D, ALA573C, ALA573D, ALA581C, ALA590C, ALA601C, ALA601D, ALA620D, ARG286D, ARG389D, ARG432C, ARG447C, ARG460C, ARG476C, ARG485C, ARG485D, ARG488D, ARG514D, ARG567C, ARG594C, ARG594D, ARG610C, ARG610D, ARG694C, ARG730C, ARG734C, ASN253D, ASN268D, ASN270D, ASN285D, ASN381D, ASN382D, ASN435C, ASN446C, ASN457C, ASN477C, ASN494D, ASN496D, ASN497D, ASN498D, ASN500D, ASN512D, ASN519D, ASN540D, ASN552D, ASN557D, ASN570C, ASN570D, ASN582C, ASN583C, ASN588C, ASN597C, ASN597D, ASN691C, ASN696C, ASN735C, ASP269D, ASP283D, ASP345D, ASP431C, ASP439C, ASP495D, ASP515D, ASP529C, ASP530C, ASP556D, ASP562C, ASP598C, ASP598D, ASP609C, ASP609D, ASP611C, ASP626D, CYS361D, CYS394D, CYS483C, CYS483D, GLN263D, GLN349D, GLN359D, GLN374D, GLN385D, GLN428C, GLN440C, GLN449C, GLN458C, GLN465C, GLN469C, GLN474C, GLN486D, GLN487D, GLN576C, GLN576D, GLN585C, GLN599C, GLN599D, GLN608C, GLN608D, GLN615D, GLN646D, GLN688C, GLN700C, GLU347D, GLU396D, GLU531C, GLU531D, GLU546D, GLU554D, GLU563C, GLU564C, GLU565C, GLU575C, GLU575D, GLU690C, GLU698C, GLY274D, GLY280D, GLY305C, GLY355D, GLY360D, GLY376D, GLY383D, GLY388D, GLY450C, GLY467C, GLY481C, GLY481D, GLY513D, GLY521D, GLY539D, GLY544D, GLY547D, GLY578C, GLY600C, GLY600D, GLY604C, GLY616D, GLY627C, GLY627D, GLY636D, GLY637D, GLY639D, GLY728C, HIS271D, HIS288D, HIS358D, HIS421C, HIS426C, HIS510D, HIS527C, HIS538D, HIS624D, HIS628C, HIS628D, HIS630C, HIS630D, HIS642D, ILE260D, ILE438C, ILE542D, ILE560D, ILE566C, ILE618D, ILE622D, ILE699C, LEU350D, LEU354D, LEU378D, LEU380D, LEU395D, LEU430C, LEU433C, LEU437C, LEU442C, LEU445C, LEU461C, LEU462C, LEU473C, LEU479C, LEU489D, LEU511D, LEU517D, LEU541D, LEU555D, LEU584C, LEU602C, LEU602D, LEU634D, LEU640D, LEU732C, LEU736C, LYS258D, LYS491D, LYS508D, LYS528C, LYS528D, LYS533D, LYS545D, LYS621D, LYS693C, MET434C, MET471C, MET524D, MET537D, MET559D, MET605C, MET605D, MET635D, PHE273D, PHE287D, PHE343D, PHE392D, PHE398D, PHE420C, PHE463C, PHE501D, PHE534D, PHE535D, PHE543D, PHE629C, PHE629D, PHE638D, PRO278D, PRO351D, PRO373D, PRO399D, PRO419C, PRO436C, PRO468C, PRO480C, PRO482C, PRO482D, PRO502D, PRO520D, PRO522D, PRO536D, PRO571C, PRO591C, PRO603C, PRO603D, PRO617D, PRO623D, PRO631D, PRO633D, PRO643D, PRO697C, SER261D, SER262D, SER267D, SER276D, SER356D, SER390D, SER391D, SER422C, SER423C, SER427C, SER429C, SER459C, SER464C, SER470C, SER472C, SER490D, SER499D, SER507D, SER516D, SER551D, SER586C, SER587C, SER632C, SER632D, SER692C, THR277D, THR379D, THR448C, THR451C, THR492D, THR504D, THR548D, THR549D, THR561D, THR568C, THR569C, THR574C, THR574D, THR579C, THR589C, THR592C, THR593C, THR595C, THR595D, THR625D, THR729C, THR733C, TRP279D, TRP304C, TRP478C, TRP503D, TRP607C, TRP607D, TRP619D, TRP695C, TYR252D, TYR272D, TYR275D, TYR281D, TYR348D, TYR352D, TYR375D, TYR377D, TYR393D, TYR397D, TYR424C, TYR441C, TYR443C, TYR444C, TYR484D, TYR509D, TYR577C, TYR613D, TYR731C, VAL353D, VAL372D, VAL387D, VAL518D, VAL558D, VAL572C, VAL572D, VAL580C, VAL596C, VAL596D, VAL606C
• C-J: ALA218J, ALA248C, ALA333C, ALA333J, ALA367C, ALA386J, ALA550C, ALA656J, ALA665J, ALA668J, ARG245C, ARG294C, ARG298C, ARG389J, ARG404C, ARG404J, ASN223C, ASN223J, ASN227C, ASN253C, ASN253J, ASN254C, ASN254J, ASN317C, ASN326J, ASN334C, ASN334J, ASN335C, ASN335J, ASN381J, ASN382J, ASN407C, ASN407J, ASN408C, ASN408J, ASN651C, ASN657J, ASN704C, ASN706C, ASN710C, ASN718C, ASP219C, ASP219J, ASP231C, ASP295C, ASP327C, ASP327J, ASP368C, ASP712C, ASP716C, CYS230C, CYS289C, CYS361C, CYS394J, GLN233C, GLN259J, GLN319C, GLN325C, GLN325J, GLN341J, GLN349J, GLN359C, GLN374C, GLN385J, GLN401J, GLN673C, GLN673J, GLN678C, GLU322C, GLU322J, GLU396J, GLU546C, GLY217J, GLY220C, GLY220J, GLY222C, GLY222J, GLY226C, GLY274J, GLY328C, GLY360C, GLY383J, GLY388J, GLY406C, GLY406J, GLY547C, GLY677C, GLY719C, HIS229C, HIS255C, HIS255J, HIS290C, HIS358C, ILE240C, ILE260J, ILE318C, ILE332C, ILE671J, LEU249C, LEU256J, LEU336C, LEU336J, LEU380J, LEU395J, LEU403J, LYS258C, LYS258J, LYS321C, LYS650J, LYS666J, LYS707C, MET371C, MET402J, PHE273J, PHE291C, PHE316C, PHE343J, PHE365C, PHE370C, PHE392J, PHE398J, PHE662J, PHE667J, PHE670J, PHE713C, PRO250C, PRO278C, PRO278J, PRO293C, PRO363C, PRO364C, PRO366C, PRO373C, PRO399J, PRO653J, PRO655J, PRO658J, PRO659J, PRO664J, SER224C, SER225C, SER232C, SER243C, SER261J, SER276J, SER292C, SER338J, SER384J, SER390J, SER391J, SER400J, SER663J, SER669J, SER675C, SER703C, SER708C, SER722C, THR241C, THR242C, THR244C, THR246C, THR251C, THR277J, THR324C, THR324J, THR329C, THR330C, THR331C, THR331J, THR337J, THR339J, THR379J, THR405C, THR405J, THR652J, THR660J, THR661J, THR672C, THR672J, THR676C, THR702C, THR714C, THR717C, TRP228C, TRP234C, TRP247C, TRP279J, TRP296C, TYR252C, TYR257J, TYR275J, TYR281C, TYR377J, TYR393J, TYR397J, TYR674C, TYR705C, TYR721C, VAL221C, VAL221J, VAL239C, VAL320C, VAL320J, VAL323C, VAL340J, VAL342J, VAL369C, VAL372C, VAL387J, VAL654J, VAL709C, VAL711C, VAL715C, VAL720C
• C-M: ARG404M, GLY222C, LEU336C, LEU336M, THR337M, VAL221C
• C-O: ARG294C, ARG294O, ARG298C, ARG298O, ARG694C, ARG694O, ASP231C, ASP231O, ASP529C, ASP529O, ASP530C, ASP530O, GLN297C, GLN297O, GLN700C, GLU690C, GLU690O, GLU698C, GLU698O, LYS693C, LYS693O, LYS707C, LYS707O, SER692C, SER692O, THR702O, TRP695C, TRP695O
• D-E: ALA367D, ALA367E, ARG245D, ARG245E, ARG294D, ARG294E, ARG298D, ARG298E, ARG567D, ARG567E, ARG694D, ARG694E, ARG725D, ARG725E, ASN301D, ASN301E, ASN302D, ASN302E, ASN303D, ASN303E, ASN691D, ASN691E, ASN696D, ASN696E, ASN704D, ASN704E, ASN706D, ASN706E, ASP231D, ASP231E, ASP295D, ASP295E, ASP529D, ASP529E, ASP530D, ASP530E, ASP562D, ASP562E, ASP712D, ASP712E, CYS230D, CYS230E, CYS289D, CYS289E, GLN233D, GLN233E, GLN297D, GLN297E, GLN700D, GLN700E, GLU532D, GLU532E, GLU564D, GLU564E, GLU565D, GLU565E, GLU690D, GLU690E, GLU698D, GLU698E, GLU723D, GLU723E, GLY236D, GLY236E, HIS288D, HIS288E, HIS290D, HIS290E, HIS527D, HIS527E, ILE699D, ILE699E, ILE727D, ILE727E, LEU235D, LEU235E, LEU614D, LEU614E, LEU732D, LEU732E, LYS689D, LYS689E, LYS693D, LYS693E, LYS707D, LYS707E, PHE291D, PHE291E, PHE365D, PHE365E, PHE713D, PHE713E, PRO293D, PRO293E, PRO363D, PRO363E, PRO364D, PRO364E, PRO366D, PRO366E, PRO697D, PRO697E, PRO724D, PRO724E, SER232D, SER232E, SER243D, SER243E, SER292D, SER292E, SER692D, SER692E, SER703D, SER703E, THR702D, THR702E, THR714D, THR714E, THR733D, THR733E, TRP234D, TRP234E, TRP296D, TRP296E, TRP304D, TRP304E, TRP695D, TRP695E, TYR701D, TYR701E, TYR705D, TYR705E, TYR721D, TYR721E, TYR731D, TYR731E, VAL711D, VAL711E, VAL715D, VAL715E
• D-H: ASN435D, ASP439D, GLN440D, GLN465D, ILE438D, LEU437D, PHE662H, PRO664H, SER663H, THR660H, THR661H, TYR441D
• D-K: ARG404K, GLY222D, LEU336D, LEU336K, THR337K, VAL221D
• D-O: ALA386D, ARG245O, ARG404D, ASN407D, ASP219O, ASP295O, ASP327D, ASP327O, ASP368O, ASP716O, GLN259D, GLU396D, GLU546O, LYS258D, LYS666D, MET402D, SER224O, SER400D, SER708O, TRP228O, TYR397D, VAL221O
• D-Q: ALA386Q, ARG245D, ARG404Q, ASP219D, ASP295D, ASP327D, ASP327Q, ASP368D, ASP716D, GLN259Q, GLU396Q, GLU546D, LYS258Q, LYS666Q, MET402Q, SER224D, SER400Q, SER708D, TRP228D, TYR397Q
• E-F: ALA218E, ALA248F, ALA333E, ALA333F, ALA367F, ALA386E, ALA550F, ALA656E, ALA665E, ALA668E, ARG245F, ARG294F, ARG298F, ARG389E, ARG404E, ARG404F, ASN223E, ASN223F, ASN227F, ASN253E, ASN253F, ASN254E, ASN254F, ASN317F, ASN326E, ASN334E, ASN334F, ASN335E, ASN335F, ASN381E, ASN382E, ASN407E, ASN407F, ASN408E, ASN408F, ASN651F, ASN657E, ASN704F, ASN706F, ASN710F, ASN718F, ASP219E, ASP219F, ASP231F, ASP295F, ASP327E, ASP327F, ASP368F, ASP712F, ASP716F, CYS230F, CYS289F, CYS361F, CYS394E, GLN233F, GLN259E, GLN319F, GLN325E, GLN325F, GLN341E, GLN349E, GLN359F, GLN374F, GLN385E, GLN401E, GLN673E, GLN673F, GLN678F, GLU322E, GLU322F, GLU396E, GLU546F, GLY217E, GLY220E, GLY220F, GLY222E, GLY222F, GLY226F, GLY274E, GLY328F, GLY360F, GLY383E, GLY388E, GLY406E, GLY406F, GLY547F, GLY677F, GLY719F, HIS229F, HIS255E, HIS255F, HIS290F, HIS358F, ILE240F, ILE260E, ILE318F, ILE332F, ILE671E, LEU249F, LEU256E, LEU336E, LEU336F, LEU380E, LEU395E, LEU403E, LYS258E, LYS258F, LYS321F, LYS650E, LYS666E, LYS707F, MET371F, MET402E, PHE273E, PHE291F, PHE316F, PHE343E, PHE365F, PHE370F, PHE392E, PHE398E, PHE662E, PHE667E, PHE670E, PHE713F, PRO250F, PRO278E, PRO278F, PRO293F, PRO363F, PRO364F, PRO366F, PRO373F, PRO399E, PRO653E, PRO655E, PRO658E, PRO659E, PRO664E, SER224F, SER225F, SER232F, SER243F, SER261E, SER276E, SER292F, SER338E, SER384E, SER390E, SER391E, SER400E, SER663E, SER669E, SER675F, SER703F, SER708F, SER722F, THR241F, THR242F, THR244F, THR246F, THR251F, THR277E, THR324E, THR324F, THR329F, THR330F, THR331E, THR331F, THR337E, THR339E, THR379E, THR405E, THR405F, THR652E, THR660E, THR661E, THR672E, THR672F, THR676F, THR714F, THR717F, TRP228F, TRP234F, TRP247F, TRP279E, TRP296F, TYR252F, TYR257E, TYR275E, TYR281F, TYR377E, TYR393E, TYR397E, TYR674F, TYR705F, TYR721F, VAL221E, VAL221F, VAL320E, VAL320F, VAL323F, VAL340E, VAL342E, VAL369F, VAL372F, VAL387E, VAL654E, VAL709F, VAL711F, VAL715F, VAL720F
• E-G: ARG404E, GLY222G, LEU336E, LEU336G, THR337E, VAL221G
• E-H: ARG404H, GLY222E, LEU336E, LEU336H, THR337H, VAL221E
• E-I: ALA357E, ALA386E, ALA425I, ALA466I, ALA475I, ALA493E, ALA505E, ALA506E, ALA523E, ALA523I, ALA525I, ALA550E, ALA553E, ALA573E, ALA573I, ALA581I, ALA590I, ALA601E, ALA601I, ALA620E, ARG286E, ARG389E, ARG432I, ARG447I, ARG460I, ARG476I, ARG485E, ARG485I, ARG488E, ARG514E, ARG567I, ARG594E, ARG594I, ARG610E, ARG610I, ARG694I, ARG730I, ARG734I, ASN253E, ASN268E, ASN270E, ASN285E, ASN381E, ASN382E, ASN435I, ASN446I, ASN457I, ASN477I, ASN494E, ASN496E, ASN497E, ASN498E, ASN500E, ASN512E, ASN519E, ASN540E, ASN552E, ASN557E, ASN570E, ASN570I, ASN582I, ASN583I, ASN588I, ASN597E, ASN597I, ASN691I, ASN696I, ASN735I, ASP269E, ASP283E, ASP345E, ASP431I, ASP439I, ASP495E, ASP515E, ASP529I, ASP530I, ASP556E, ASP562I, ASP598E, ASP598I, ASP609E, ASP609I, ASP611I, ASP626E, CYS289E, CYS361E, CYS394E, CYS483E, GLN263E, GLN349E, GLN359E, GLN374E, GLN385E, GLN428I, GLN440I, GLN449I, GLN458I, GLN465I, GLN469I, GLN474I, GLN486E, GLN487E, GLN576E, GLN576I, GLN585I, GLN599E, GLN599I, GLN608E, GLN608I, GLN615E, GLN646E, GLN688I, GLN700I, GLU347E, GLU396E, GLU531E, GLU531I, GLU554E, GLU564I, GLU565I, GLU575E, GLU575I, GLU690I, GLU698I, GLY274E, GLY280E, GLY305I, GLY355E, GLY360E, GLY376E, GLY383E, GLY388E, GLY450I, GLY467I, GLY481E, GLY481I, GLY513E, GLY521E, GLY539E, GLY544E, GLY547E, GLY578I, GLY600E, GLY600I, GLY604I, GLY616E, GLY627E, GLY627I, GLY636E, GLY637E, GLY639E, GLY728I, HIS271E, HIS288E, HIS358E, HIS421I, HIS426I, HIS510E, HIS510I, HIS527I, HIS538E, HIS624E, HIS628E, HIS628I, HIS630E, HIS630I, HIS642E, ILE260E, ILE438I, ILE542E, ILE560E, ILE566I, ILE618E, ILE622E, ILE699I, LEU350E, LEU354E, LEU378E, LEU380E, LEU395E, LEU430I, LEU433I, LEU437I, LEU442I, LEU445I, LEU461I, LEU462I, LEU473I, LEU479I, LEU489E, LEU511E, LEU517E, LEU541E, LEU555E, LEU584E, LEU584I, LEU602E, LEU602I, LEU634E, LEU640E, LEU732I, LEU736I, LYS258E, LYS491E, LYS508E, LYS528E, LYS528I, LYS533E, LYS545E, LYS621E, LYS693I, MET434I, MET471I, MET524E, MET537E, MET559E, MET605E, MET605I, MET635E, PHE273E, PHE287E, PHE343E, PHE392E, PHE398E, PHE420I, PHE463I, PHE501E, PHE534E, PHE535E, PHE543E, PHE629E, PHE629I, PHE638E, PRO278E, PRO351E, PRO373E, PRO399E, PRO419I, PRO436I, PRO468I, PRO480I, PRO482E, PRO482I, PRO502E, PRO520E, PRO522E, PRO536E, PRO571I, PRO591I, PRO603E, PRO603I, PRO617E, PRO623E, PRO631E, PRO633E, PRO643E, PRO697I, SER261E, SER262E, SER267E, SER276E, SER356E, SER390E, SER391E, SER422I, SER423I, SER427I, SER429I, SER459I, SER464I, SER470I, SER472I, SER490E, SER499E, SER507E, SER516E, SER551E, SER586I, SER587I, SER632E, SER632I, SER692I, THR277E, THR379E, THR448I, THR451I, THR492E, THR504E, THR548E, THR549E, THR561E, THR568I, THR569I, THR574E, THR574I, THR579I, THR589I, THR592I, THR593I, THR595E, THR595I, THR625E, THR729I, THR733I, TRP279E, TRP304I, TRP478I, TRP503E, TRP607E, TRP607I, TRP619E, TRP695I, TYR252E, TYR272E, TYR275E, TYR281E, TYR348E, TYR352E, TYR375E, TYR377E, TYR393E, TYR397E, TYR424I, TYR441I, TYR443I, TYR444I, TYR484E, TYR509E, TYR577I, TYR613E, TYR731I, VAL353E, VAL372E, VAL387E, VAL518E, VAL558E, VAL572E, VAL572I, VAL580I, VAL596E, VAL596I, VAL606I
• E-K: ASN435E, ASP439E, GLN440E, GLN465E, ILE438E, LEU437E, PHE662K, PRO664K, SER663K, THR661K, TYR441E
• E-Q: ALA357Q, ALA493Q, ALA550Q, ALA553Q, ARG389Q, ARG432E, ARG460E, ARG476E, ARG485Q, ARG514Q, ARG567E, ARG594E, ARG694E, ARG730E, ARG734E, ASN435E, ASN477E, ASN496Q, ASN497Q, ASN498Q, ASN500Q, ASN512Q, ASN583E, ASN691E, ASN696E, ASP269Q, ASP345Q, ASP431E, ASP439E, ASP495Q, ASP529E, ASP598E, ASP598Q, ASP609E, ASP626Q, GLN349Q, GLN359Q, GLN374Q, GLN440E, GLN449E, GLN458E, GLN465E, GLN487Q, GLN585E, GLU347Q, GLU554Q, GLU565E, GLU575E, GLU698E, GLY355Q, GLY627Q, HIS271Q, HIS358Q, HIS421E, HIS426E, HIS510Q, HIS624Q, HIS628Q, HIS630E, ILE542Q, LEU380Q, LEU517Q, LEU634Q, LEU736E, LYS508Q, LYS528E, LYS621Q, LYS693E, MET605E, MET635Q, PHE392Q, PHE463E, PHE629Q, SER390Q, SER391Q, SER427E, SER459E, SER472E, SER499Q, SER587E, THR448E, THR579E, TRP607E, TRP695E, TYR397Q, TYR441E, TYR443E, TYR484Q, TYR509Q, TYR577E
• F-G: ALA218F, ALA248G, ALA333F, ALA333G, ALA367G, ALA386F, ALA550G, ALA656F, ALA665F, ALA668F, ARG245G, ARG294G, ARG298G, ARG389F, ARG404F, ARG404G, ASN223F, ASN223G, ASN227G, ASN253F, ASN253G, ASN254F, ASN254G, ASN317G, ASN326F, ASN334F, ASN334G, ASN335F, ASN335G, ASN381F, ASN382F, ASN407F, ASN407G, ASN408F, ASN408G, ASN651G, ASN657F, ASN704G, ASN706G, ASN710G, ASN718G, ASP219F, ASP219G, ASP231G, ASP295G, ASP327F, ASP327G, ASP368G, ASP712G, ASP716G, CYS230G, CYS289G, CYS361G, CYS394F, GLN233G, GLN259F, GLN319G, GLN325F, GLN325G, GLN341F, GLN349F, GLN359G, GLN374G, GLN385F, GLN401F, GLN673F, GLN673G, GLN678G, GLU322F, GLU322G, GLU396F, GLU546G, GLY217F, GLY220F, GLY220G, GLY222F, GLY222G, GLY226G, GLY274F, GLY328G, GLY360G, GLY383F, GLY388F, GLY406F, GLY406G, GLY547G, GLY677G, GLY719G, HIS229G, HIS255F, HIS255G, HIS290G, HIS358G, ILE240G, ILE260F, ILE318G, ILE332G, ILE671F, LEU249G, LEU256F, LEU336F, LEU336G, LEU380F, LEU395F, LEU403F, LYS258F, LYS258G, LYS321G, LYS650F, LYS666F, LYS707G, MET371G, MET402F, PHE273F, PHE291G, PHE316G, PHE343F, PHE365G, PHE370G, PHE392F, PHE398F, PHE662F, PHE667F, PHE670F, PHE713G, PRO250G, PRO278F, PRO278G, PRO293G, PRO363G, PRO364G, PRO366G, PRO373G, PRO399F, PRO653F, PRO655F, PRO658F, PRO659F, PRO664F, SER224G, SER225G, SER232G, SER243G, SER261F, SER276F, SER292G, SER338F, SER384F, SER390F, SER391F, SER400F, SER663F, SER669F, SER675G, SER703G, SER708G, SER722G, THR241G, THR242G, THR244G, THR246G, THR251G, THR277F, THR324F, THR324G, THR329G, THR330G, THR331F, THR331G, THR337F, THR339F, THR379F, THR405F, THR405G, THR652F, THR660F, THR661F, THR672F, THR672G, THR676G, THR702G, THR714G, THR717G, TRP228G, TRP234G, TRP247G, TRP279F, TRP296G, TYR252G, TYR257F, TYR275F, TYR281G, TYR377F, TYR393F, TYR397F, TYR674G, TYR705G, TYR721G, VAL221F, VAL221G, VAL320F, VAL320G, VAL323G, VAL340F, VAL342F, VAL369G, VAL372G, VAL387F, VAL654F, VAL709G, VAL711G, VAL715G, VAL720G
• F-H: ARG404F, GLY222H, LEU336F, LEU336H, THR337F
• F-I: ALA367F, ALA367I, ARG245F, ARG245I, ARG294F, ARG294I, ARG298F, ARG298I, ARG567F, ARG567I, ARG694F, ARG694I, ARG725F, ARG725I, ASN301F, ASN301I, ASN302F, ASN302I, ASN303F, ASN303I, ASN691F, ASN691I, ASN696F, ASN696I, ASN704F, ASN704I, ASN706F, ASN706I, ASP231F, ASP231I, ASP295F, ASP295I, ASP529F, ASP529I, ASP530F, ASP530I, ASP562F, ASP562I, ASP712F, ASP712I, CYS230F, CYS230I, CYS289F, CYS289I, GLN233F, GLN233I, GLN297F, GLN297I, GLN700F, GLN700I, GLU532F, GLU532I, GLU564F, GLU564I, GLU565F, GLU565I, GLU690F, GLU690I, GLU698F, GLU698I, GLU723F, GLU723I, GLY236F, GLY236I, HIS288F, HIS288I, HIS290F, HIS290I, HIS527F, HIS527I, ILE699F, ILE699I, ILE727F, ILE727I, LEU235F, LEU235I, LEU614F, LEU614I, LEU732F, LEU732I, LYS689F, LYS689I, LYS693F, LYS693I, LYS707F, LYS707I, PHE291F, PHE291I, PHE365F, PHE365I, PHE713F, PHE713I, PRO293F, PRO293I, PRO363F, PRO363I, PRO364F, PRO364I, PRO366F, PRO366I, PRO697F, PRO697I, PRO724F, PRO724I, SER232F, SER232I, SER243F, SER243I, SER292F, SER292I, SER692F, SER692I, SER703F, SER703I, THR702F, THR702I, THR714F, THR714I, THR733F, THR733I, TRP234F, TRP234I, TRP296F, TRP296I, TRP304F, TRP304I, TRP695F, TRP695I, TYR701F, TYR701I, TYR705F, TYR705I, TYR721F, TYR721I, TYR731F, TYR731I, VAL711F, VAL711I, VAL715F, VAL715I
• F-L: ASN435F, ASP439F, GLN440F, GLN465F, ILE438F, LEU437F, PHE662L, PRO664L, SER663L, THR660L, THR661L, TYR441F
• F-P: ALA357P, ALA550P, ALA553P, ARG389P, ARG432F, ARG460F, ARG476F, ARG485P, ARG514P, ARG567F, ARG594F, ARG694F, ARG730F, ARG734F, ASN435F, ASN477F, ASN496P, ASN497P, ASN498P, ASN500P, ASN512P, ASN583F, ASN691F, ASN696F, ASP269P, ASP345P, ASP431F, ASP439F, ASP495P, ASP529F, ASP598F, ASP598P, ASP609F, ASP626P, GLN349P, GLN359P, GLN374P, GLN440F, GLN449F, GLN458F, GLN465F, GLN487P, GLN585F, GLN599F, GLU347P, GLU554P, GLU565F, GLU575F, GLU698F, GLY355P, GLY627P, HIS271P, HIS358P, HIS421F, HIS426F, HIS510P, HIS624P, HIS628P, HIS630F, ILE542P, LEU517P, LEU634P, LEU736F, LYS508P, LYS528F, LYS693F, MET605F, MET635P, PHE392P, PHE463F, PHE629P, SER390P, SER391P, SER422F, SER472F, SER507P, SER587F, THR448F, THR579F, TRP607F, TRP695F, TYR397P, TYR441F, TYR443F, TYR509P, TYR577F
• G-H: ALA218G, ALA248H, ALA333G, ALA333H, ALA367H, ALA386G, ALA550H, ALA656G, ALA665G, ALA668G, ARG245H, ARG294H, ARG298H, ARG389G, ARG404G, ARG404H, ASN223G, ASN223H, ASN227H, ASN253G, ASN253H, ASN254G, ASN254H, ASN317H, ASN326G, ASN334G, ASN334H, ASN335G, ASN335H, ASN381G, ASN382G, ASN407G, ASN407H, ASN408G, ASN408H, ASN651H, ASN657G, ASN704H, ASN706H, ASN710H, ASN718H, ASP219G, ASP219H, ASP231H, ASP295H, ASP327G, ASP327H, ASP368H, ASP712H, ASP716H, CYS230H, CYS289H, CYS361H, CYS394G, GLN233H, GLN259G, GLN319H, GLN325G, GLN325H, GLN341G, GLN349G, GLN359H, GLN374H, GLN385G, GLN401G, GLN673G, GLN673H, GLN678H, GLU322G, GLU322H, GLU396G, GLU546H, GLY217G, GLY220G, GLY220H, GLY222G, GLY222H, GLY226H, GLY274G, GLY328H, GLY360H, GLY383G, GLY388G, GLY406G, GLY406H, GLY547H, GLY677H, GLY719H, HIS229H, HIS255G, HIS255H, HIS290H, HIS358H, ILE240H, ILE260G, ILE318H, ILE332H, ILE671G, LEU249H, LEU256G, LEU336G, LEU336H, LEU380G, LEU395G, LEU403G, LYS258G, LYS258H, LYS321H, LYS650G, LYS666G, LYS707H, MET371H, MET402G, PHE273G, PHE291H, PHE316H, PHE343G, PHE365H, PHE370H, PHE392G, PHE398G, PHE662G, PHE667G, PHE670G, PHE713H, PRO250H, PRO278G, PRO278H, PRO293H, PRO363H, PRO364H, PRO366H, PRO373H, PRO399G, PRO653G, PRO655G, PRO658G, PRO659G, PRO664G, SER224H, SER225H, SER232H, SER243H, SER261G, SER276G, SER292H, SER338G, SER384G, SER390G, SER391G, SER400G, SER663G, SER669G, SER675H, SER703H, SER708H, SER722H, THR241H, THR242H, THR244H, THR246H, THR251H, THR277G, THR324G, THR324H, THR329H, THR330H, THR331G, THR331H, THR337G, THR339G, THR379G, THR405G, THR405H, THR652G, THR660G, THR661G, THR672G, THR672H, THR676H, THR702H, THR714H, THR717H, TRP228H, TRP234H, TRP247H, TRP279G, TRP296H, TYR252H, TYR257G, TYR275G, TYR281H, TYR377G, TYR393G, TYR397G, TYR674H, TYR705H, TYR721H, VAL221G, VAL221H, VAL320G, VAL320H, VAL323H, VAL340G, VAL342G, VAL369H, VAL372H, VAL387G, VAL654G, VAL709H, VAL711H, VAL715H, VAL720H
• I-L: ARG404L, GLY222I, LEU336I, LEU336L, THR337L, VAL221I
• I-P: ALA386P, ARG245I, ARG404P, ASP219I, ASP327I, ASP327P, ASP368I, ASP716I, GLN259P, GLU396P, GLU546I, LYS258P, LYS666P, MET402P, PRO655P, SER224I, SER400P, SER708I, TRP228I, TYR674I, VAL221I
• I-Q: ALA357I, ALA550I, ALA553I, ARG389I, ARG432Q, ARG460Q, ARG485I, ARG514I, ARG567Q, ARG594Q, ARG694Q, ARG730Q, ARG734Q, ASN270I, ASN435Q, ASN477Q, ASN496I, ASN497I, ASN498I, ASN500I, ASN512I, ASN552I, ASN583Q, ASN691Q, ASN696Q, ASP269I, ASP345I, ASP431Q, ASP439Q, ASP495I, ASP529Q, ASP598I, ASP598Q, ASP609Q, ASP626I, GLN349I, GLN359I, GLN374I, GLN440Q, GLN449Q, GLN458Q, GLN465Q, GLN487I, GLN585Q, GLU347I, GLU554I, GLU565Q, GLU575Q, GLU698Q, GLY355I, GLY627I, HIS271I, HIS358I, HIS421Q, HIS426Q, HIS510I, HIS624I, HIS628I, HIS630Q, ILE542I, LEU380I, LEU517I, LEU634I, LEU736Q, LYS508I, LYS528Q, LYS621I, LYS693Q, MET605Q, MET635I, PHE392I, PHE463Q, PHE501I, PHE629I, SER390I, SER422Q, SER427Q, SER464Q, SER472Q, SER587Q, THR448Q, THR579Q, TRP607Q, TRP695Q, TYR397I, TYR441Q, TYR443Q, TYR577Q
• I-R: ALA386I, ARG245R, ARG404I, ASN407I, ASP219R, ASP327I, ASP327R, ASP368R, ASP716R, GLN259I, GLU396I, GLU546R, LYS258I, LYS666I, MET402I, SER224R, SER400I, SER708R, TRP228R, VAL221R
• J-M: ALA218M, ALA333J, ALA333M, ALA367J, ALA386M, ARG245J, ARG294J, ARG298J, ARG389M, ARG404J, ARG404M, ASN223J, ASN223M, ASN227J, ASN253M, ASN254M, ASN317J, ASN326M, ASN334J, ASN334M, ASN335J, ASN335M, ASN381M, ASN382M, ASN407J, ASN407M, ASN408J, ASN408M, ASN704J, ASN706J, ASN710J, ASN718J, ASP219J, ASP219M, ASP231J, ASP295J, ASP327J, ASP327M, ASP368J, ASP712J, ASP716J, CYS230J, CYS289J, CYS394M, GLN233J, GLN259M, GLN319J, GLN325M, GLN341M, GLN349M, GLN385M, GLN401M, GLN678J, GLU322M, GLU396M, GLU546J, GLY217M, GLY220J, GLY220M, GLY222J, GLY222M, GLY226J, GLY274M, GLY328J, GLY383M, GLY388M, GLY406J, GLY406M, GLY677J, GLY719J, HIS229J, HIS255M, HIS290J, ILE240J, ILE260M, ILE318J, ILE332J, LEU256M, LEU336J, LEU336M, LEU380M, LEU395M, LEU403M, LYS258M, LYS321J, LYS666M, LYS707J, MET402M, PHE273M, PHE291J, PHE316J, PHE343M, PHE365J, PHE392M, PHE398M, PHE713J, PRO278M, PRO293J, PRO364J, PRO366J, PRO399M, SER224J, SER225J, SER232J, SER243J, SER261M, SER276M, SER292J, SER338M, SER384M, SER390M, SER391M, SER400M, SER703J, SER708J, SER722J, THR241J, THR242J, THR244J, THR246J, THR277M, THR324M, THR329J, THR330J, THR331J, THR331M, THR337M, THR339M, THR379M, THR405J, THR405M, THR676J, THR702J, THR714J, THR717J, TRP228J, TRP234J, TRP279M, TRP296J, TYR257M, TYR275M, TYR377M, TYR393M, TYR397M, TYR705J, TYR721J, VAL221J, VAL221M, VAL239J, VAL320J, VAL320M, VAL340M, VAL342M, VAL369J, VAL387M, VAL709J, VAL711J, VAL715J, VAL720J
• J-O: ALA357J, ALA493J, ALA550J, ALA553J, ARG389J, ARG432O, ARG460O, ARG485J, ARG514J, ARG567O, ARG594O, ARG694O, ARG730O, ARG734O, ASN270J, ASN382J, ASN435O, ASN477O, ASN496J, ASN497J, ASN498J, ASN500J, ASN512J, ASN552J, ASN583O, ASN691O, ASN696O, ASN735O, ASP269J, ASP345J, ASP431O, ASP439O, ASP495J, ASP529O, ASP530O, ASP598J, ASP598O, ASP609O, ASP626J, GLN349J, GLN359J, GLN374J, GLN440O, GLN449O, GLN458O, GLN465O, GLN487J, GLN585O, GLU347J, GLU554J, GLU564O, GLU565O, GLU575O, GLU698O, GLY355J, GLY627J, HIS271J, HIS358J, HIS421O, HIS426O, HIS510J, HIS624J, HIS628J, HIS630O, ILE542J, LEU380J, LEU517J, LEU634J, LEU736O, LYS508J, LYS528O, LYS621J, LYS693O, MET605O, MET635J, PHE392J, PHE463O, PHE501J, PHE629J, SER390J, SER427O, SER459O, SER464O, SER472O, SER499J, SER587O, THR448O, THR504J, THR579O, THR593O, TRP607O, TRP695O, TYR393J, TYR397J, TYR424O, TYR441O, TYR443O, TYR577O
• K-Q: ALA386K, ARG245Q, ARG404K, ASN407K, ASP219Q, ASP327K, ASP327Q, ASP368Q, ASP716Q, GLN259K, GLN319Q, GLU396K, GLU546Q, LYS258K, LYS666K, SER224Q, SER400K, SER708Q, THR337K, TRP228Q, VAL221Q
• K-R: ALA357K, ALA550K, ALA553K, ARG389K, ARG432R, ARG460R, ARG485K, ARG514K, ARG567R, ARG594R, ARG694R, ARG730R, ARG734R, ASN270K, ASN435R, ASN477R, ASN496K, ASN497K, ASN498K, ASN500K, ASN512K, ASN552K, ASN583R, ASN691R, ASN696R, ASN735R, ASP269K, ASP345K, ASP431R, ASP439R, ASP495K, ASP529R, ASP598K, ASP598R, ASP609R, ASP626K, GLN349K, GLN359K, GLN374K, GLN440R, GLN449R, GLN458R, GLN465R, GLN487K, GLN585R, GLU347K, GLU554K, GLU565R, GLU575R, GLU698R, GLY355K, GLY627K, HIS271K, HIS358K, HIS421R, HIS426R, HIS510K, HIS624K, HIS628K, HIS630R, ILE542K, LEU380K, LEU517K, LEU634K, LEU736R, LYS508K, LYS528R, LYS621K, LYS693R, MET605R, MET635K, PHE392K, PHE463R, PHE501K, PHE629K, SER390K, SER427R, SER464R, SER472R, SER499K, SER587R, THR448R, THR504K, THR548K, THR579R, THR593R, TRP607R, TRP695R, TYR393K, TYR397K, TYR441R, TYR443R, TYR577R
• K-S: ALA386S, ARG245K, ARG404S, ASP219K, ASP327K, ASP327S, ASP368K, ASP716K, GLN259S, GLN319K, GLU396S, GLU546K, LYS258S, LYS666S, PRO655S, SER400S, SER708K, THR337S, TRP228K, TYR674K, VAL221K
• L-P: ALA386L, ARG245P, ARG404L, ASN407L, ASP219P, ASP327L, ASP327P, ASP368P, ASP716P, GLN259L, GLU396L, GLU546P, LYS258L, LYS666L, MET402L, PRO655L, SER224P, SER400L, SER708P, TRP228P, TYR674P, VAL221P
• L-T: ALA386T, ARG245L, ARG404T, ASP219L, ASP327L, ASP327T, ASP368L, ASP716L, GLN259T, GLN319L, GLU396T, GLU546L, LYS258T, LYS666T, PRO655T, SER400T, SER708L, THR337T, TRP228L, TYR674L
• M-N: ALA386N, ARG245M, ARG404N, ASP219M, ASP295M, ASP327M, ASP327N, ASP368M, ASP716M, GLN259N, GLU396N, GLU546M, LYS258N, LYS666N, SER400N, SER708M, TRP228M, TYR397N, VAL221M
• O-S: ALA386O, ARG245S, ARG404O, ASN407O, ASP219S, ASP327O, ASP327S, ASP368S, ASP716S, GLN259O, GLN319S, GLU396O, GLU546S, LYS258O, LYS666O, SER224S, SER400O, SER708S, THR337O, TRP228S
• Q-R: ARG294Q, ARG294R, ARG298Q, ARG298R, ARG694Q, ARG694R, ASP231Q, ASP231R, ASP529Q, ASP529R, ASP530Q, ASP530R, GLN297Q, GLN297R, GLN700Q, GLU690Q, GLU690R, GLU698Q, GLU698R, LYS693Q, LYS693R, LYS707Q, LYS707R, SER692Q, SER692R, THR702R, TRP695Q, TRP695R
• R-T: ALA386R, ARG245T, ARG404R, ASN407R, ASP219T, ASP327R, ASP327T, ASP368T, ASP716T, GLN259R, GLN319T, GLU396R, GLU546T, LYS258R, LYS666R, MET402R, PRO655R, SER224T, SER400R, SER708T, THR337R, TRP228T, TYR674T, VAL221T