3KFB

crystal structure of a group ii chaperonin from methanococcus maripaludis

• Total interactions analyzed: 28
• Total true interactions: 22
• Strongest Interaction:
  • Chains: E-F
  • Int. Res.: 255
  • Norm. En. per Res.: -3.4739
• Hub Node: A(6)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-182.443	-39.698	-653.279	-875.4199	255	37	11	27399	13	130	149
A-C	0.0	0.0	-1.6842	-1.6842	10	0	0	208	0	3	3
A-D	0.0	0.0	-0.0026	-0.0026	2	0	0	3	0	1	1
A-F	0.0	0.0	-0.0061	-0.0061	2	0	0	6	0	2	1
A-G	0.0	-6.9972	-1.5973	-8.5944	13	0	0	268	0	3	3
A-H	-171.066	-37.0093	-655.548	-863.6233	256	44	11	27342	14	132	151
B-C	-154.353	-35.8306	-584.484	-774.6677	250	25	11	25670	13	122	146
B-D	0.0	0.0	-1.7337	-1.7337	12	0	0	249	0	4	3
B-E	0.0	0.0	-0.0055	-0.0055	2	0	0	5	0	2	1
B-G	0.0	0.0	-0.0004	-0.0004	2	0	0	1	0	2	1
B-H	0.0	-6.5945	-2.4444	-9.0389	14	0	0	290	0	3	3
C-D	-118.8704	-22.4684	-629.033	-770.3718	255	33	11	26862	16	132	151
C-E	0.0	-7.0199	-1.7273	-8.7472	12	0	0	282	0	4	3
C-F	0.0	0.0	-0.0004	-0.0004	2	0	0	1	0	2	1
D-E	-168.1964	-39.4695	-663.176	-870.8419	256	43	11	27374	14	131	151
D-F	0.0	-6.6949	-2.7758	-9.4707	14	0	0	310	0	3	3
E-F	-186.0848	-41.3998	-658.367	-885.8516	255	34	11	27443	13	131	149
E-G	0.0	0.0	-1.8027	-1.8027	10	0	0	218	0	3	3
E-H	0.0	0.0	-0.0025	-0.0025	2	0	0	3	0	1	1
F-G	-151.0997	-36.1547	-582.836	-770.0904	250	28	11	25731	13	123	146
F-H	0.0	0.0	-1.6962	-1.6962	12	0	0	251	0	4	3
G-H	-96.8883	-20.1264	-607.471	-724.4857	254	35	10	26624	15	131	150

Interface residues

• A-B: ALA126B, ALA163A, ALA166A, ALA201A, ALA20B, ALA221A, ALA238B, ALA248A, ALA248B, ALA256A, ALA27B, ALA294A, ALA299A, ALA318B, ALA323B, ALA445A, ALA448A, ALA498B, ALA502B, ALA503B, ALA517B, ALA518B, ALA74B, ALA75B, ALA82B, ARG14B, ARG218A, ARG251A, ARG251B, ARG307A, ARG346A, ARG370A, ARG382A, ARG493B, ARG511B, ASN11B, ASN236B, ASN24B, ASN324B, ASN328B, ASN447A, ASN59A, ASP183B, ASP184B, ASP189B, ASP191B, ASP204A, ASP205A, ASP247A, ASP247B, ASP254A, ASP254B, ASP271B, ASP291A, ASP292A, ASP331B, ASP336B, ASP351A, ASP45A, ASP50A, ASP513B, ASP514B, ASP51A, ASP54A, CYS237B, GLN125B, GLN129B, GLN132B, GLN21B, GLN222A, GLN264A, GLN264B, GLN287B, GLN295A, GLN497B, GLN500B, GLN85B, GLU164A, GLU185B, GLU217A, GLU240A, GLU243A, GLU243B, GLU245B, GLU249A, GLU249B, GLU260A, GLU260B, GLU263A, GLU263B, GLU265A, GLU265B, GLU266A, GLU275B, GLU315B, GLU33A, GLU374A, GLU378A, GLU379A, GLU446A, GLU504B, GLU507B, GLU519B, GLU67A, GLU71A, GLU71B, GLU80B, GLU88B, GLY160A, GLY162A, GLY17B, GLY200A, GLY350A, GLY371A, GLY40A, GLY43A, GLY449A, GLY53A, HIS116B, HIS296A, HIS375A, HIS72A, HIS72B, ILE119B, ILE158A, ILE203A, ILE241A, ILE241B, ILE250A, ILE250B, ILE252A, ILE252B, ILE262A, ILE262B, ILE30A, ILE31A, ILE326B, ILE329B, ILE348A, ILE377A, ILE499B, ILE512B, ILE516B, ILE64A, ILE79B, LEU111B, LEU192B, LEU258A, LEU258B, LEU269A, LEU293A, LEU332B, LEU450A, LEU48A, LEU509B, LEU510B, LEU52A, LEU65A, LEU78B, LYS122B, LYS13B, LYS161A, LYS165A, LYS167A, LYS187B, LYS190B, LYS198A, LYS216A, LYS225A, LYS226A, LYS242A, LYS242B, LYS257A, LYS257B, LYS267B, LYS270A, LYS288B, LYS300A, LYS311B, LYS316B, LYS319B, LYS330B, LYS347A, LYS42A, LYS46A, LYS76B, LYS83B, LYS87B, MET12B, MET16B, MET23B, MET259A, MET259B, MET268A, MET268B, MET272B, MET314B, MET44A, MET47A, MET508B, MET68A, MET77B, PHE261A, PHE261B, PHE476A, PRO117B, PRO255A, PRO41A, PRO73B, SER199A, SER202A, SER220A, SER333B, SER349A, SER352A, SER37A, SER501B, SER505B, SER69A, THR118B, THR159A, THR244A, THR244B, THR246B, THR253A, THR253B, THR327B, THR34A, THR372A, THR373A, THR38A, THR496B, THR506B, THR58A, THR84B, TYR15B, TYR297A, VAL120B, VAL121B, VAL188B, VAL219A, VAL325B, VAL35A, VAL376A, VAL380A, VAL475A, VAL49A, VAL515B, VAL55A, VAL56A, VAL57A, VAL70A, VAL70B, VAL81B, VAL89B
• A-C: ALA248C, ARG251A, ARG251C, ASP247C, GLU249C, ILE252A, ILE262A, LEU258A, THR244C, THR246C
• A-D: ARG251A, ARG251D
• A-F: ARG251A, ARG251F
• A-G: ALA248A, ARG251A, ARG251G, ASP247A, GLU249A, GLU249G, ILE250G, ILE252G, ILE262G, LEU258G, PHE261G, THR244A, THR246A
• A-H: ALA126A, ALA163H, ALA166H, ALA201H, ALA20A, ALA221H, ALA238A, ALA248A, ALA248H, ALA256H, ALA27A, ALA294H, ALA299H, ALA318A, ALA323A, ALA445H, ALA448H, ALA498A, ALA502A, ALA503A, ALA517A, ALA518A, ALA74A, ALA75A, ALA82A, ARG14A, ARG218H, ARG251A, ARG251H, ARG307H, ARG346H, ARG370H, ARG382H, ARG493A, ARG511A, ASN11A, ASN236A, ASN24A, ASN324A, ASN328A, ASN447H, ASN59H, ASP183A, ASP184A, ASP189A, ASP191A, ASP204H, ASP205H, ASP247A, ASP247H, ASP254A, ASP254H, ASP271A, ASP291H, ASP292H, ASP331A, ASP336A, ASP351H, ASP45H, ASP50H, ASP513A, ASP514A, ASP51H, ASP54H, CYS237A, GLN125A, GLN129A, GLN132A, GLN21A, GLN222H, GLN264A, GLN264H, GLN287A, GLN295H, GLN497A, GLN500A, GLN85A, GLU164H, GLU185A, GLU217H, GLU240H, GLU243A, GLU243H, GLU245A, GLU249A, GLU249H, GLU260A, GLU260H, GLU263A, GLU263H, GLU265A, GLU265H, GLU266A, GLU266H, GLU275A, GLU315A, GLU33H, GLU374H, GLU378H, GLU379H, GLU446H, GLU504A, GLU507A, GLU519A, GLU67H, GLU71A, GLU71H, GLU80A, GLU88A, GLY160H, GLY162H, GLY17A, GLY200H, GLY350H, GLY371H, GLY40H, GLY43H, GLY449H, GLY53H, HIS116A, HIS296H, HIS375H, HIS72A, HIS72H, ILE119A, ILE158H, ILE203H, ILE241A, ILE241H, ILE250A, ILE250H, ILE252A, ILE252H, ILE262A, ILE262H, ILE30H, ILE31H, ILE326A, ILE329A, ILE348H, ILE377H, ILE499A, ILE512A, ILE516A, ILE64H, ILE79A, LEU111A, LEU192A, LEU258A, LEU258H, LEU269H, LEU293H, LEU332A, LEU450H, LEU48H, LEU509A, LEU510A, LEU52H, LEU65H, LEU78A, LYS122A, LYS13A, LYS161H, LYS165H, LYS167H, LYS187A, LYS190A, LYS198H, LYS216H, LYS225H, LYS226H, LYS242A, LYS242H, LYS257A, LYS257H, LYS267A, LYS270H, LYS288A, LYS300H, LYS311A, LYS316A, LYS319A, LYS330A, LYS347H, LYS42H, LYS46H, LYS76A, LYS83A, LYS87A, MET12A, MET16A, MET23A, MET259A, MET259H, MET268A, MET268H, MET272A, MET314A, MET44H, MET47H, MET508A, MET68H, MET77A, PHE261A, PHE261H, PHE476H, PRO117A, PRO255H, PRO41H, PRO73A, SER199H, SER202H, SER220H, SER333A, SER349H, SER352H, SER37H, SER501A, SER505A, SER69H, THR118A, THR159H, THR244A, THR244H, THR246A, THR253A, THR253H, THR327A, THR34H, THR372H, THR373H, THR38H, THR496A, THR506A, THR58H, THR84A, TYR15A, TYR297H, VAL120A, VAL121A, VAL188A, VAL219H, VAL325A, VAL35H, VAL376H, VAL380H, VAL475H, VAL49H, VAL515A, VAL55H, VAL56H, VAL57H, VAL70A, VAL70H, VAL81A, VAL89A
• B-C: ALA126C, ALA163B, ALA166B, ALA201B, ALA20C, ALA221B, ALA238C, ALA248B, ALA248C, ALA256B, ALA27C, ALA294B, ALA299B, ALA318C, ALA323C, ALA445B, ALA448B, ALA498C, ALA502C, ALA503C, ALA517C, ALA518C, ALA74C, ALA75C, ALA82C, ARG14C, ARG218B, ARG251B, ARG251C, ARG307B, ARG346B, ARG370B, ARG382B, ARG493C, ARG511C, ASN11C, ASN236C, ASN24C, ASN324C, ASN328C, ASN447B, ASN59B, ASP183C, ASP184C, ASP189C, ASP191C, ASP204B, ASP205B, ASP247B, ASP247C, ASP254B, ASP254C, ASP271C, ASP291B, ASP292B, ASP331C, ASP336C, ASP351B, ASP45B, ASP50B, ASP513C, ASP514C, ASP51B, ASP54B, CYS237C, GLN125C, GLN129C, GLN132C, GLN21C, GLN222B, GLN264B, GLN264C, GLN287C, GLN295B, GLN497C, GLN500C, GLN85C, GLU164B, GLU185C, GLU217B, GLU240B, GLU243B, GLU243C, GLU245C, GLU249B, GLU249C, GLU260B, GLU260C, GLU263B, GLU263C, GLU265B, GLU265C, GLU266B, GLU315C, GLU33B, GLU374B, GLU378B, GLU379B, GLU446B, GLU504C, GLU507C, GLU519C, GLU67B, GLU71B, GLU71C, GLU80C, GLU88C, GLY160B, GLY162B, GLY17C, GLY200B, GLY350B, GLY371B, GLY40B, GLY43B, GLY449B, GLY53B, HIS116C, HIS296B, HIS375B, HIS72B, HIS72C, ILE119C, ILE158B, ILE203B, ILE241B, ILE241C, ILE250B, ILE250C, ILE252B, ILE252C, ILE262B, ILE262C, ILE30B, ILE31B, ILE326C, ILE329C, ILE348B, ILE377B, ILE499C, ILE512C, ILE516C, ILE64B, ILE79C, LEU111C, LEU192C, LEU258B, LEU269B, LEU293B, LEU332C, LEU450B, LEU48B, LEU509C, LEU510C, LEU52B, LEU65B, LEU78C, LYS122C, LYS13C, LYS161B, LYS165B, LYS167B, LYS187C, LYS190C, LYS198B, LYS216B, LYS225B, LYS226B, LYS242B, LYS242C, LYS257B, LYS257C, LYS267C, LYS270B, LYS288C, LYS300B, LYS311C, LYS319C, LYS330C, LYS347B, LYS42B, LYS46B, LYS76C, LYS83C, LYS87C, MET12C, MET16C, MET23C, MET259B, MET259C, MET268B, MET268C, MET272C, MET44B, MET47B, MET508C, MET68B, MET77C, PHE261B, PHE261C, PHE476B, PRO117C, PRO255B, PRO41B, PRO73C, SER199B, SER202B, SER220B, SER333C, SER349B, SER352B, SER37B, SER501C, SER505C, SER69B, THR118C, THR159B, THR244B, THR244C, THR246C, THR253B, THR253C, THR327C, THR34B, THR372B, THR373B, THR38B, THR496C, THR506C, THR58B, THR84C, TYR15C, TYR297B, VAL120C, VAL121C, VAL188C, VAL219B, VAL325C, VAL35B, VAL376B, VAL380B, VAL475B, VAL49B, VAL515C, VAL55B, VAL56B, VAL57B, VAL70B, VAL81C, VAL89C
• B-D: ALA248D, ARG251B, ARG251D, ASP247D, GLU249B, GLU249D, ILE252B, ILE262B, LEU258B, THR244D, THR246D, THR253B
• B-E: ARG251B, ARG251E
• B-G: ARG251B, ARG251G
• B-H: ALA248B, ARG251B, ARG251H, ASP247B, GLU249B, GLU249H, ILE252H, ILE262H, LEU258H, PHE261H, PRO255H, THR244B, THR246B, THR253H
• C-D: ALA126D, ALA163C, ALA166C, ALA201C, ALA20D, ALA221C, ALA238D, ALA248C, ALA248D, ALA256C, ALA27D, ALA294C, ALA299C, ALA318D, ALA323D, ALA445C, ALA448C, ALA498D, ALA502D, ALA503D, ALA517D, ALA518D, ALA74D, ALA75D, ALA82D, ARG14D, ARG218C, ARG251C, ARG251D, ARG307C, ARG346C, ARG370C, ARG382C, ARG493D, ARG511D, ASN11D, ASN236D, ASN24D, ASN324D, ASN328D, ASN447C, ASN59C, ASP183D, ASP184D, ASP189D, ASP191D, ASP204C, ASP205C, ASP247C, ASP247D, ASP254C, ASP254D, ASP271D, ASP291C, ASP292C, ASP331D, ASP336D, ASP351C, ASP45C, ASP50C, ASP513D, ASP514D, ASP51C, ASP54C, CYS237D, GLN125D, GLN129D, GLN132D, GLN21D, GLN222C, GLN264C, GLN264D, GLN287D, GLN295C, GLN497D, GLN500D, GLN85D, GLU164C, GLU185D, GLU217C, GLU240C, GLU243C, GLU243D, GLU245D, GLU249C, GLU249D, GLU260C, GLU260D, GLU263C, GLU263D, GLU265C, GLU265D, GLU266C, GLU266D, GLU275D, GLU315D, GLU33C, GLU374C, GLU378C, GLU379C, GLU446C, GLU504D, GLU507D, GLU519D, GLU67C, GLU71C, GLU71D, GLU80D, GLU88D, GLY160C, GLY162C, GLY17D, GLY200C, GLY350C, GLY371C, GLY40C, GLY43C, GLY449C, GLY53C, HIS116D, HIS296C, HIS375C, HIS72C, HIS72D, ILE119D, ILE158C, ILE203C, ILE241C, ILE241D, ILE250C, ILE250D, ILE252C, ILE252D, ILE262C, ILE262D, ILE30C, ILE31C, ILE326D, ILE329D, ILE348C, ILE377C, ILE499D, ILE512D, ILE516D, ILE64C, ILE79D, LEU111D, LEU192D, LEU258C, LEU269C, LEU293C, LEU332D, LEU450C, LEU48C, LEU509D, LEU510D, LEU52C, LEU65C, LEU78D, LYS122D, LYS13D, LYS161C, LYS165C, LYS167C, LYS187D, LYS190D, LYS198C, LYS216C, LYS225C, LYS226C, LYS242C, LYS242D, LYS257C, LYS257D, LYS267D, LYS270C, LYS288D, LYS300C, LYS311D, LYS316D, LYS319D, LYS330D, LYS347C, LYS42C, LYS46C, LYS76D, LYS83D, LYS87D, MET12D, MET16D, MET23D, MET259C, MET259D, MET268C, MET268D, MET272D, MET314D, MET44C, MET47C, MET508D, MET68C, MET77D, PHE261C, PHE261D, PHE476C, PRO117D, PRO255C, PRO41C, PRO73D, SER199C, SER202C, SER220C, SER333D, SER349C, SER352C, SER37C, SER501D, SER505D, SER69C, THR118D, THR159C, THR244C, THR244D, THR246D, THR253C, THR253D, THR327D, THR34C, THR372C, THR373C, THR38C, THR496D, THR506D, THR58C, THR84D, TYR15D, TYR297C, VAL120D, VAL121D, VAL188D, VAL219C, VAL325D, VAL35C, VAL376C, VAL380C, VAL475C, VAL49C, VAL515D, VAL55C, VAL56C, VAL57C, VAL70C, VAL70D, VAL81D, VAL89D
• C-E: ALA248E, ARG251C, ARG251E, ASP247E, GLU249C, GLU249E, ILE252C, ILE262C, LEU258C, PHE261C, THR244E, THR246E
• C-F: ARG251C, ARG251F
• D-E: ALA126E, ALA163D, ALA166D, ALA201D, ALA20E, ALA221D, ALA238E, ALA248D, ALA248E, ALA256D, ALA27E, ALA294D, ALA299D, ALA318E, ALA323E, ALA445D, ALA448D, ALA498E, ALA502E, ALA503E, ALA517E, ALA518E, ALA74E, ALA75E, ALA82E, ARG14E, ARG218D, ARG251D, ARG251E, ARG307D, ARG346D, ARG370D, ARG382D, ARG493E, ARG511E, ASN11E, ASN236E, ASN24E, ASN324E, ASN328E, ASN447D, ASN59D, ASP183E, ASP184E, ASP189E, ASP191E, ASP204D, ASP205D, ASP247D, ASP247E, ASP254D, ASP254E, ASP271E, ASP291D, ASP292D, ASP331E, ASP336E, ASP351D, ASP45D, ASP50D, ASP513E, ASP514E, ASP51D, ASP54D, CYS237E, GLN125E, GLN129E, GLN132E, GLN21E, GLN222D, GLN264D, GLN264E, GLN287E, GLN295D, GLN497E, GLN500E, GLN85E, GLU164D, GLU185E, GLU217D, GLU240D, GLU243D, GLU243E, GLU245E, GLU249D, GLU249E, GLU260D, GLU260E, GLU263D, GLU263E, GLU265D, GLU265E, GLU266D, GLU266E, GLU275E, GLU315E, GLU33D, GLU374D, GLU378D, GLU379D, GLU446D, GLU504E, GLU507E, GLU519E, GLU67D, GLU71D, GLU71E, GLU80E, GLU88E, GLY160D, GLY162D, GLY17E, GLY200D, GLY350D, GLY371D, GLY40D, GLY43D, GLY449D, GLY53D, HIS116E, HIS296D, HIS375D, HIS72D, HIS72E, ILE119E, ILE158D, ILE203D, ILE241D, ILE241E, ILE250D, ILE250E, ILE252D, ILE252E, ILE262D, ILE262E, ILE30D, ILE31D, ILE326E, ILE329E, ILE348D, ILE377D, ILE499E, ILE512E, ILE516E, ILE64D, ILE79E, LEU111E, LEU192E, LEU258D, LEU258E, LEU269D, LEU293D, LEU332E, LEU450D, LEU48D, LEU509E, LEU510E, LEU52D, LEU65D, LEU78E, LYS122E, LYS13E, LYS161D, LYS165D, LYS167D, LYS187E, LYS190E, LYS198D, LYS216D, LYS225D, LYS226D, LYS242D, LYS242E, LYS257D, LYS257E, LYS267E, LYS270D, LYS288E, LYS300D, LYS311E, LYS316E, LYS319E, LYS330E, LYS347D, LYS42D, LYS46D, LYS76E, LYS83E, LYS87E, MET12E, MET16E, MET23E, MET259D, MET259E, MET268D, MET268E, MET272E, MET314E, MET44D, MET47D, MET508E, MET68D, MET77E, PHE261D, PHE261E, PHE476D, PRO117E, PRO255D, PRO41D, PRO73E, SER199D, SER202D, SER220D, SER333E, SER349D, SER352D, SER37D, SER501E, SER505E, SER69D, THR118E, THR159D, THR244D, THR244E, THR246E, THR253D, THR253E, THR327E, THR34D, THR372D, THR373D, THR38D, THR496E, THR506E, THR58D, THR84E, TYR15E, TYR297D, VAL120E, VAL121E, VAL188E, VAL219D, VAL325E, VAL35D, VAL376D, VAL380D, VAL475D, VAL49D, VAL515E, VAL55D, VAL56D, VAL57D, VAL70D, VAL70E, VAL81E, VAL89E
• D-F: ALA248F, ARG251D, ARG251F, ASP247F, GLU249D, GLU249F, ILE252D, ILE262D, LEU258D, PHE261D, PRO255D, THR244F, THR246F, THR253D
• E-F: ALA126F, ALA163E, ALA166E, ALA201E, ALA20F, ALA221E, ALA238F, ALA248E, ALA248F, ALA256E, ALA27F, ALA294E, ALA299E, ALA318F, ALA323F, ALA445E, ALA448E, ALA498F, ALA502F, ALA503F, ALA517F, ALA518F, ALA74F, ALA75F, ALA82F, ARG14F, ARG218E, ARG251E, ARG251F, ARG307E, ARG346E, ARG370E, ARG382E, ARG493F, ARG511F, ASN11F, ASN236F, ASN24F, ASN324F, ASN328F, ASN447E, ASN59E, ASP183F, ASP184F, ASP189F, ASP191F, ASP204E, ASP205E, ASP247E, ASP247F, ASP254E, ASP254F, ASP271F, ASP291E, ASP292E, ASP331F, ASP336F, ASP351E, ASP45E, ASP50E, ASP513F, ASP514F, ASP51E, ASP54E, CYS237F, GLN125F, GLN129F, GLN132F, GLN21F, GLN222E, GLN264E, GLN264F, GLN287F, GLN295E, GLN497F, GLN500F, GLN85F, GLU164E, GLU185F, GLU217E, GLU240E, GLU243E, GLU243F, GLU245F, GLU249E, GLU249F, GLU260E, GLU260F, GLU263E, GLU263F, GLU265E, GLU265F, GLU266E, GLU275F, GLU315F, GLU33E, GLU374E, GLU378E, GLU379E, GLU446E, GLU504F, GLU507F, GLU519F, GLU67E, GLU71E, GLU71F, GLU80F, GLU88F, GLY160E, GLY162E, GLY17F, GLY200E, GLY350E, GLY371E, GLY40E, GLY43E, GLY449E, GLY53E, HIS116F, HIS296E, HIS375E, HIS72E, HIS72F, ILE119F, ILE158E, ILE203E, ILE241E, ILE241F, ILE250E, ILE250F, ILE252E, ILE252F, ILE262E, ILE262F, ILE30E, ILE31E, ILE326F, ILE329F, ILE348E, ILE377E, ILE499F, ILE512F, ILE516F, ILE64E, ILE79F, LEU111F, LEU192F, LEU258E, LEU258F, LEU269E, LEU293E, LEU332F, LEU450E, LEU48E, LEU509F, LEU510F, LEU52E, LEU65E, LEU78F, LYS122F, LYS13F, LYS161E, LYS165E, LYS167E, LYS187F, LYS190F, LYS198E, LYS216E, LYS225E, LYS226E, LYS242E, LYS242F, LYS257E, LYS257F, LYS267F, LYS270E, LYS288F, LYS300E, LYS311F, LYS316F, LYS319F, LYS330F, LYS347E, LYS42E, LYS46E, LYS76F, LYS83F, LYS87F, MET12F, MET16F, MET23F, MET259E, MET259F, MET268E, MET268F, MET272F, MET314F, MET44E, MET47E, MET508F, MET68E, MET77F, PHE261E, PHE261F, PHE476E, PRO117F, PRO255E, PRO41E, PRO73F, SER199E, SER202E, SER220E, SER333F, SER349E, SER352E, SER37E, SER501F, SER505F, SER69E, THR118F, THR159E, THR244E, THR244F, THR246F, THR253E, THR253F, THR327F, THR34E, THR372E, THR373E, THR38E, THR496F, THR506F, THR58E, THR84F, TYR15F, TYR297E, VAL120F, VAL121F, VAL188F, VAL219E, VAL325F, VAL35E, VAL376E, VAL380E, VAL475E, VAL49E, VAL515F, VAL55E, VAL56E, VAL57E, VAL70E, VAL70F, VAL81F, VAL89F
• E-G: ALA248G, ARG251E, ARG251G, ASP247G, GLU249G, ILE252E, ILE262E, LEU258E, THR244G, THR246G
• E-H: ARG251E, ARG251H
• F-G: ALA126G, ALA163F, ALA166F, ALA201F, ALA20G, ALA221F, ALA238G, ALA248F, ALA248G, ALA256F, ALA27G, ALA294F, ALA299F, ALA318G, ALA323G, ALA445F, ALA448F, ALA498G, ALA502G, ALA503G, ALA517G, ALA518G, ALA74G, ALA75G, ALA82G, ARG14G, ARG218F, ARG251F, ARG251G, ARG307F, ARG346F, ARG370F, ARG382F, ARG493G, ARG511G, ASN11G, ASN236G, ASN24G, ASN324G, ASN328G, ASN447F, ASN59F, ASP183G, ASP184G, ASP189G, ASP191G, ASP204F, ASP205F, ASP247F, ASP247G, ASP254F, ASP254G, ASP271G, ASP291F, ASP292F, ASP331G, ASP336G, ASP351F, ASP45F, ASP50F, ASP513G, ASP514G, ASP51F, ASP54F, CYS237G, GLN125G, GLN129G, GLN132G, GLN21G, GLN222F, GLN264F, GLN264G, GLN287G, GLN295F, GLN497G, GLN500G, GLN85G, GLU164F, GLU185G, GLU217F, GLU240F, GLU243F, GLU243G, GLU245G, GLU249F, GLU249G, GLU260F, GLU260G, GLU263F, GLU263G, GLU265F, GLU265G, GLU266F, GLU315G, GLU33F, GLU374F, GLU378F, GLU379F, GLU446F, GLU504G, GLU507G, GLU519G, GLU67F, GLU71F, GLU71G, GLU80G, GLU88G, GLY160F, GLY162F, GLY17G, GLY200F, GLY350F, GLY371F, GLY40F, GLY43F, GLY449F, GLY53F, HIS116G, HIS296F, HIS375F, HIS72F, HIS72G, ILE119G, ILE158F, ILE203F, ILE241F, ILE241G, ILE250F, ILE250G, ILE252F, ILE252G, ILE262F, ILE262G, ILE30F, ILE31F, ILE326G, ILE329G, ILE348F, ILE377F, ILE499G, ILE512G, ILE516G, ILE64F, ILE79G, LEU111G, LEU192G, LEU258F, LEU269F, LEU293F, LEU332G, LEU450F, LEU48F, LEU509G, LEU510G, LEU52F, LEU65F, LEU78G, LYS122G, LYS13G, LYS161F, LYS165F, LYS167F, LYS187G, LYS190G, LYS198F, LYS216F, LYS225F, LYS226F, LYS242F, LYS242G, LYS257F, LYS257G, LYS267G, LYS270F, LYS288G, LYS300F, LYS311G, LYS319G, LYS330G, LYS347F, LYS42F, LYS46F, LYS76G, LYS83G, LYS87G, MET12G, MET16G, MET23G, MET259F, MET259G, MET268F, MET268G, MET272G, MET44F, MET47F, MET508G, MET68F, MET77G, PHE261F, PHE261G, PHE476F, PRO117G, PRO255F, PRO41F, PRO73G, SER199F, SER202F, SER220F, SER333G, SER349F, SER352F, SER37F, SER501G, SER505G, SER69F, THR118G, THR159F, THR244F, THR244G, THR246G, THR253F, THR253G, THR327G, THR34F, THR372F, THR373F, THR38F, THR496G, THR506G, THR58F, THR84G, TYR15G, TYR297F, VAL120G, VAL121G, VAL188G, VAL219F, VAL325G, VAL35F, VAL376F, VAL380F, VAL475F, VAL49F, VAL515G, VAL55F, VAL56F, VAL57F, VAL70F, VAL81G, VAL89G
• F-H: ALA248H, ARG251F, ARG251H, ASP247H, GLU249F, GLU249H, ILE252F, ILE262F, LEU258F, THR244H, THR246H, THR253F
• G-H: ALA126H, ALA163G, ALA166G, ALA201G, ALA20H, ALA221G, ALA238H, ALA248G, ALA248H, ALA256G, ALA27H, ALA294G, ALA299G, ALA318H, ALA323H, ALA445G, ALA448G, ALA498H, ALA502H, ALA503H, ALA517H, ALA518H, ALA74H, ALA75H, ALA82H, ARG14H, ARG218G, ARG251G, ARG251H, ARG307G, ARG346G, ARG370G, ARG382G, ARG493H, ARG511H, ASN11H, ASN236H, ASN24H, ASN324H, ASN328H, ASN447G, ASN59G, ASP183H, ASP184H, ASP189H, ASP191H, ASP204G, ASP205G, ASP247G, ASP247H, ASP254G, ASP254H, ASP271H, ASP291G, ASP292G, ASP331H, ASP336H, ASP351G, ASP45G, ASP50G, ASP513H, ASP514H, ASP51G, ASP54G, CYS237H, GLN125H, GLN129H, GLN132H, GLN21H, GLN222G, GLN264G, GLN264H, GLN287H, GLN295G, GLN497H, GLN500H, GLN85H, GLU164G, GLU185H, GLU217G, GLU240G, GLU243G, GLU243H, GLU245H, GLU249G, GLU249H, GLU260G, GLU260H, GLU263G, GLU263H, GLU265G, GLU265H, GLU266G, GLU266H, GLU275H, GLU315H, GLU33G, GLU374G, GLU378G, GLU379G, GLU446G, GLU504H, GLU507H, GLU519H, GLU67G, GLU71G, GLU71H, GLU80H, GLU88H, GLY160G, GLY162G, GLY17H, GLY200G, GLY350G, GLY371G, GLY40G, GLY43G, GLY449G, GLY53G, HIS116H, HIS296G, HIS375G, HIS72G, HIS72H, ILE119H, ILE158G, ILE203G, ILE241G, ILE241H, ILE250G, ILE250H, ILE252G, ILE252H, ILE262G, ILE262H, ILE30G, ILE31G, ILE326H, ILE329H, ILE348G, ILE377G, ILE499H, ILE512H, ILE516H, ILE64G, ILE79H, LEU111H, LEU192H, LEU258G, LEU269G, LEU293G, LEU332H, LEU450G, LEU48G, LEU509H, LEU510H, LEU52G, LEU65G, LEU78H, LYS122H, LYS161G, LYS165G, LYS167G, LYS187H, LYS190H, LYS198G, LYS216G, LYS225G, LYS226G, LYS242G, LYS242H, LYS257G, LYS257H, LYS267H, LYS270G, LYS288H, LYS300G, LYS311H, LYS316H, LYS319H, LYS330H, LYS347G, LYS42G, LYS46G, LYS76H, LYS83H, LYS87H, MET12H, MET16H, MET23H, MET259G, MET259H, MET268G, MET268H, MET272H, MET314H, MET44G, MET47G, MET508H, MET68G, MET77H, PHE261G, PHE261H, PHE476G, PRO117H, PRO255G, PRO41G, PRO73H, SER199G, SER202G, SER220G, SER333H, SER349G, SER352G, SER37G, SER501H, SER505H, SER69G, THR118H, THR159G, THR244G, THR244H, THR246H, THR253G, THR253H, THR327H, THR34G, THR372G, THR373G, THR38G, THR496H, THR506H, THR58G, THR84H, TYR15H, TYR297G, VAL120H, VAL121H, VAL188H, VAL219G, VAL325H, VAL35G, VAL376G, VAL380G, VAL475G, VAL49G, VAL515H, VAL55G, VAL56G, VAL57G, VAL70G, VAL70H, VAL81H, VAL89H