3KC3

mk2 complexed to inhibitor n4-(7-(benzofuran-2-yl)-1h-indazol-5-yl) pyrimidine-2,4-diamine

• Total interactions analyzed: 66
• Total true interactions: 30
• Strongest Interaction:
  • Chains: D-F
  • Int. Res.: 56
  • Norm. En. per Res.: -4.0017
• Hub Node: A(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-66.1433	8.2492	-175.083	-232.9771	64	9	7	7427	0	18	19
A-C	-54.643	12.4143	-187.914	-230.1427	68	12	4	8011	0	21	19
A-E	-3.4536	20.2233	-23.4937	-6.724	34	2	0	1697	0	0	7
A-F	-30.9987	-11.2786	-200.907	-243.1843	102	10	3	9196	5	30	22
A-H	-29.1341	-62.6968	-220.555	-312.3859	103	9	5	9698	5	29	23
B-C	-54.6725	3.5449	-159.946	-211.0736	68	12	4	7009	1	20	20
B-E	-29.0518	-13.4696	-211.386	-253.9074	98	6	4	9270	5	30	24
B-J	-29.0659	-13.507	-204.272	-246.8448	105	15	4	9743	4	28	25
B-L	0.0	5.5011	-14.1268	-8.6257	29	0	0	1390	0	0	6
C-H	0.0	0.0	-10.1568	-10.1568	20	4	0	883	0	0	6
C-I	-9.8735	-7.4526	-182.795	-200.1211	93	9	0	8438	3	29	24
C-L	-23.8901	-62.3163	-205.135	-291.3414	100	8	3	9669	6	32	23
D-E	-56.7749	0.8558	-163.817	-219.7362	60	14	4	7109	1	19	19
D-F	-53.552	0.6155	-171.16	-224.0965	56	16	6	7487	1	18	20
D-G	-8.3837	3.2961	-151.039	-156.1266	81	3	0	7261	3	30	26
D-J	0.0	17.2335	-24.5189	-7.2854	28	8	0	1667	0	0	8
D-K	-3.7332	-12.7757	-140.319	-156.8279	81	3	0	7023	5	28	25
E-F	-36.3791	-6.5146	-166.07	-208.9637	64	7	7	7188	2	19	19
E-J	-14.4572	-65.8957	-215.185	-295.5379	95	5	3	9696	5	29	23
F-G	-13.0575	12.5819	-25.8517	-26.3273	36	2	0	1853	0	1	11
F-H	-16.64	-64.0776	-217.36	-298.0776	103	12	4	9560	5	30	26
G-H	-42.1326	5.3565	-156.133	-192.9091	59	8	4	7231	0	17	20
G-I	-43.2763	-1.0747	-172.643	-216.994	66	15	5	7730	1	19	20
G-K	-22.8864	-2.2488	-156.081	-181.2162	87	4	0	7277	5	28	23
H-I	-56.5271	-3.6096	-157.01	-217.1467	60	8	4	6874	1	17	19
I-K	0.0	20.4301	-28.0598	-7.6297	34	5	0	1603	0	2	9
I-L	-34.1787	-59.6989	-240.796	-334.6736	110	13	4	10469	4	30	24
J-K	-30.5104	3.0634	-184.741	-212.1879	61	17	6	7840	1	19	21
J-L	-62.9419	10.3102	-188.413	-241.0447	72	20	7	8507	1	22	24
K-L	-49.4819	1.6686	-216.165	-263.9783	66	15	5	8627	2	19	19

Interface residues

• A-B: ALA111B, ALA129A, ALA58A, ARG110B, ARG131A, ASN126A, ASN181B, ASN57A, ASP61A, CYS133A, GLN113B, GLN45B, GLN53A, GLN53B, GLN68A, GLN80A, GLN96A, GLU106B, GLU125A, GLU213B, GLY130A, GLY51B, HIS108B, HIS178B, HIS47B, ILE180B, ILE182B, ILE54A, ILE54B, ILE59A, ILE60A, ILE81A, LEU107B, LEU127A, LEU135A, LEU177B, LEU52B, LEU79A, LEU92A, LYS132A, LYS49B, LYS55A, LYS56A, LYS56B, LYS64A, LYS77A, MET94A, PHE46B, PHE82A, PRO44B, SER112B, SER179B, SER50B, SER67A, THR214B, THR215B, THR66A, TRP109B, TYR124A, TYR128A, TYR176B, TYR63A, VAL48B, VAL65A
• A-C: ALA111A, ALA129C, ALA58C, ARG102A, ARG102C, ARG110A, ARG131C, ASN126C, ASN181A, ASN57C, ASP61C, ASP62C, ASP97C, CYS133C, GLN113A, GLN45A, GLN53A, GLN53C, GLN68C, GLU106A, GLU125C, GLU213A, GLY130C, GLY51A, HIS108A, HIS178A, HIS47A, ILE180A, ILE182A, ILE54A, ILE54C, ILE59C, ILE60C, LEU107A, LEU127C, LEU135C, LEU177A, LEU52A, LEU79C, LEU92C, LYS132C, LYS49A, LYS55C, LYS56A, LYS56C, LYS64C, LYS77C, LYS84C, MET94C, PHE43A, PHE46A, PRO44A, SER112A, SER179A, SER50A, SER67C, THR214A, THR215A, THR66C, TRP109A, TYR124C, TYR128C, TYR176A, TYR63C, VAL105A, VAL48A, VAL65C, VAL69C
• A-E: ALA129A, ALA129E, ARG131A, ARG131E, ARG278E, ARG280A, ARG280E, CYS133E, GLN96A, GLN96E, GLY130A, GLY130E, GLY274A, GLY274E, HIS267A, ILE271A, ILE271E, LYS276A, LYS276E, LYS77A, LYS77E, MET275E, MET281E, MET94A, MET94E, PRO273A, PRO273E, SER272A, SER272E, SER67E, THR277A, THR277E, TYR128A, TYR128E
• A-F: ALA231F, ARG185A, ARG278A, ARG280A, ARG303A, ARG313A, ARG313F, ASN181F, ASN266A, ASN304A, ASN304F, ASN321F, ASP186A, ASP241A, ASP245A, ASP345A, CYS244A, GLN175F, GLN283A, GLN312A, GLN312F, GLN45F, GLU190A, GLU233F, GLU238F, GLU285A, GLU309A, GLU309F, GLU318F, GLU347A, GLY236F, GLY259A, GLY274A, GLY282A, HIS178F, HIS267A, HIS47F, ILE174F, ILE180F, ILE182F, ILE252A, ILE255A, ILE271A, ILE279A, ILE316F, LEU177F, LEU235F, LEU305A, LEU306A, LYS188A, LYS239F, LYS242F, LYS276A, LYS307A, LYS307F, LYS346A, MET246A, MET246F, MET275A, MET281A, MET314F, MET320F, MET326F, PHE210A, PHE263A, PHE46F, PRO189A, PRO227F, PRO232F, PRO237F, PRO261A, PRO262A, PRO273A, PRO310A, PRO310F, SER179F, SER243A, SER243F, SER248A, SER265A, SER272A, THR214F, THR215F, THR277A, THR308A, THR311A, THR311F, THR315F, THR317F, TRP247A, TYR176F, TYR228F, TYR229F, TYR240A, TYR240F, TYR260A, TYR264A, TYR284A, VAL187A, VAL230F, VAL234F, VAL251A
• A-H: ALA231A, ARG185H, ARG278H, ARG280H, ARG303H, ARG313A, ARG313H, ARG348H, ASN181A, ASN191H, ASN266H, ASN304A, ASN304H, ASN321A, ASP186H, ASP241H, ASP245H, CYS244H, GLN175A, GLN283H, GLN312A, GLN312H, GLU190H, GLU233A, GLU238A, GLU285H, GLU309A, GLU309H, GLU318A, GLU350H, GLY236A, GLY274H, GLY282H, HIS178A, HIS184H, HIS47A, ILE174A, ILE180A, ILE182A, ILE252H, ILE255H, ILE279H, ILE316A, ILE74H, LEU177A, LEU235A, LEU249H, LEU305H, LEU306H, LYS188H, LYS239A, LYS242A, LYS242H, LYS276H, LYS307A, LYS307H, MET246A, MET246H, MET275H, MET281H, MET314A, MET320A, PHE147H, PHE210H, PHE263H, PHE43A, PRO189H, PRO227A, PRO232A, PRO237A, PRO261H, PRO262H, PRO273H, PRO310A, PRO310H, PRO44A, SER179A, SER243A, SER243H, SER248H, SER265H, SER272H, THR214A, THR215A, THR277H, THR308H, THR311A, THR311H, THR315A, THR317A, TRP247H, TYR176A, TYR228A, TYR229A, TYR240A, TYR240H, TYR260H, TYR264H, TYR284H, VAL187H, VAL230A, VAL234A, VAL251H
• B-C: ALA111C, ALA129B, ALA58B, ARG102B, ARG102C, ARG110C, ARG131B, ASN126B, ASN181C, ASN57B, ASP61B, ASP62B, ASP97B, CYS133B, GLN113C, GLN42C, GLN45C, GLN53B, GLN53C, GLN68B, GLN96B, GLU106C, GLU125B, GLU213C, GLY130B, GLY236C, GLY51C, HIS108C, HIS47C, ILE180C, ILE182C, ILE54B, ILE54C, ILE59B, ILE60B, ILE81B, LEU107C, LEU127B, LEU135B, LEU235C, LEU52C, LEU79B, LEU92B, LYS132B, LYS49C, LYS55B, LYS56B, LYS56C, LYS64B, LYS77B, MET94B, PHE43C, PHE46C, PRO44C, SER112C, SER179C, SER50C, SER67B, THR214C, THR66B, TRP109C, TYR124B, TYR128B, TYR176C, TYR63B, VAL105C, VAL48C, VAL65B
• B-E: ALA231B, ARG185E, ARG278E, ARG280E, ARG303E, ARG313B, ARG313E, ASN181B, ASN266E, ASN304B, ASN304E, ASN321B, ASP186E, ASP241E, ASP245E, CYS244E, GLN175B, GLN283E, GLN312B, GLN312E, GLN45B, GLU190E, GLU233B, GLU238B, GLU285E, GLU309B, GLU309E, GLU318B, GLY236B, GLY274E, GLY282E, HIS178B, HIS47B, ILE174B, ILE180B, ILE182B, ILE252E, ILE255E, ILE271E, ILE279E, ILE316B, LEU177B, LEU235B, LEU249E, LEU305E, LEU306E, LYS188E, LYS239B, LYS239E, LYS242B, LYS276E, LYS307B, LYS307E, MET246E, MET275E, MET281E, MET314B, MET320B, MET326B, PHE147E, PHE210E, PHE263E, PHE46B, PRO189E, PRO227B, PRO232B, PRO237B, PRO261E, PRO262E, PRO273E, PRO310B, PRO310E, SER179B, SER243B, SER243E, SER248E, SER265E, SER272E, THR214B, THR215B, THR277E, THR308E, THR311B, THR311E, THR315B, THR317B, TRP247E, TYR176B, TYR228B, TYR229B, TYR240B, TYR240E, TYR264E, TYR284E, VAL187E, VAL230B, VAL234B, VAL251E
• B-J: ALA231J, ARG185B, ARG278B, ARG280B, ARG303B, ARG313B, ARG313J, ASN181J, ASN191B, ASN304B, ASN304J, ASN321J, ASP186B, ASP241B, ASP245B, CYS244B, GLN175J, GLN283B, GLN312B, GLN312J, GLU190B, GLU233J, GLU238J, GLU285B, GLU309B, GLU309J, GLU318J, GLY236J, GLY274B, GLY282B, HIS178J, HIS217J, HIS47J, ILE174J, ILE180J, ILE182J, ILE252B, ILE255B, ILE271B, ILE279B, ILE316J, ILE74B, LEU177J, LEU235J, LEU249B, LEU305B, LEU306B, LYS188B, LYS239J, LYS242B, LYS242J, LYS276B, LYS307B, LYS307J, MET246B, MET275B, MET281B, MET314J, MET320J, MET326J, PHE147B, PHE210B, PHE263B, PHE286B, PHE43J, PRO189B, PRO227J, PRO232J, PRO237J, PRO261B, PRO262B, PRO273B, PRO310B, PRO310J, PRO323J, PRO44J, SER179J, SER216J, SER243B, SER243J, SER248B, SER265B, SER272B, THR214J, THR215J, THR277B, THR308B, THR311B, THR311J, THR315J, THR317J, TRP247B, TRP349B, TYR176J, TYR228J, TYR229J, TYR240B, TYR240J, TYR260B, TYR264B, TYR284B, VAL187B, VAL230J, VAL234J, VAL251B
• B-L: ALA129B, ALA129L, ARG131B, ARG131L, ARG280B, ARG280L, CYS133B, CYS133L, GLN96B, GLN96L, GLY130B, GLY274B, GLY274L, ILE271B, ILE271L, LYS276B, LYS276L, LYS77B, LYS77L, MET281B, MET94B, PRO273B, PRO273L, SER272B, SER272L, THR277B, THR277L, TYR128B, TYR128L
• C-H: ALA129C, ALA129H, ARG131C, ARG131H, ARG280C, ARG280H, GLN96C, GLN96H, GLY130H, GLY274H, LYS276C, LYS276H, LYS77C, MET275C, MET94C, PRO273H, SER272H, THR277C, THR277H, TYR128C
• C-I: ALA231I, ARG185C, ARG278C, ARG280C, ARG303C, ARG313C, ARG313I, ASN181I, ASN304C, ASN304I, ASN321I, ASP186C, ASP241C, ASP245C, CYS244C, GLN175I, GLN283C, GLN312C, GLN312I, GLU190C, GLU233I, GLU238I, GLU285C, GLU309C, GLU309I, GLU318I, GLY236I, GLY250C, GLY282C, HIS178I, ILE174I, ILE180I, ILE182I, ILE252C, ILE255C, ILE279C, ILE316I, LEU177I, LEU192C, LEU235I, LEU249C, LEU256C, LEU305C, LEU306C, LYS188C, LYS239C, LYS239I, LYS242I, LYS276C, LYS307C, LYS307I, MET246C, MET246I, MET253C, MET275C, MET281C, MET314I, MET320I, MET326I, PHE147C, PHE210C, PHE263C, PRO189C, PRO232I, PRO237I, PRO261C, PRO262C, PRO310C, PRO310I, SER179I, SER243C, SER243I, SER248C, THR214I, THR215I, THR277C, THR308C, THR311C, THR311I, THR315I, THR317I, TRP247C, TYR176I, TYR229I, TYR240C, TYR240I, TYR254C, TYR264C, TYR284C, VAL187C, VAL230I, VAL234I, VAL251C
• C-L: ALA231C, ARG185L, ARG278L, ARG280L, ARG303L, ARG313C, ARG313L, ASN181C, ASN191L, ASN304C, ASN304L, ASN321C, ASP186L, ASP241L, ASP245L, CYS244L, GLN175C, GLN283L, GLN312C, GLN312L, GLU190L, GLU233C, GLU238C, GLU285L, GLU309C, GLU309L, GLU318C, GLY236C, GLY274L, GLY282L, HIS178C, HIS47C, ILE174C, ILE180C, ILE182C, ILE252L, ILE255L, ILE271L, ILE279L, ILE316C, LEU177C, LEU235C, LEU249L, LEU305L, LEU306L, LYS188L, LYS239C, LYS239L, LYS242C, LYS242L, LYS276L, LYS307C, LYS307L, MET246C, MET246L, MET275L, MET281L, MET314C, MET320C, MET326C, PHE147L, PHE210L, PHE263L, PHE43C, PRO189L, PRO227C, PRO232C, PRO237C, PRO261L, PRO262L, PRO273L, PRO310C, PRO310L, SER179C, SER243C, SER243L, SER248L, SER265L, SER272L, THR214C, THR277L, THR308L, THR311C, THR311L, THR315C, THR317C, TRP247L, TYR176C, TYR228C, TYR229C, TYR240C, TYR240L, TYR254L, TYR260L, TYR264L, TYR284L, VAL187L, VAL230C, VAL234C, VAL251L
• D-E: ALA111E, ALA129D, ALA58D, ARG110E, ARG131D, ASN126D, ASN181E, ASN57D, ASP61D, ASP97D, CYS133D, GLN113E, GLN45E, GLN53D, GLN53E, GLN68D, GLU106E, GLU125D, GLU213E, GLY130D, GLY51E, HIS178E, HIS47E, ILE180E, ILE182E, ILE54D, ILE54E, ILE59D, ILE60D, ILE81D, LEU107E, LEU127D, LEU135D, LEU235E, LEU52E, LEU79D, LEU92D, LYS132D, LYS242E, LYS49E, LYS55D, LYS56D, LYS64D, LYS77D, MET94D, PHE46E, PRO44E, SER112E, SER179E, SER50E, SER67D, THR214E, THR215E, THR66D, TRP109E, TYR124D, TYR128D, TYR176E, VAL48E, VAL65D
• D-F: ALA111D, ALA129F, ALA58F, ARG102D, ARG110D, ARG131F, ASN126F, ASN181D, ASN57F, ASP61F, ASP62F, ASP97F, CYS133F, GLN113D, GLN53D, GLN53F, GLU106D, GLU125F, GLY130F, GLY51D, HIS178D, HIS47D, ILE180D, ILE182D, ILE54D, ILE54F, ILE59F, ILE60F, ILE81F, LEU107D, LEU127F, LEU135F, LEU177D, LEU52D, LEU79F, LEU92F, LYS132F, LYS49D, LYS55F, LYS56D, LYS56F, LYS64F, MET94F, PHE46D, SER112D, SER179D, SER50D, SER67F, THR66F, TRP109D, TYR124F, TYR128F, TYR176D, TYR63F, VAL48D, VAL65F
• D-G: ALA231D, ARG185G, ARG278G, ARG280G, ARG303G, ARG313D, ARG313G, ASN181D, ASN304D, ASN304G, ASN321D, ASP186G, ASP241G, ASP245G, CYS244G, GLN175D, GLN283G, GLN312D, GLN312G, GLU233D, GLU238D, GLU285G, GLU309D, GLU309G, GLU318D, GLY236D, GLY274G, GLY282G, HIS178D, HIS267G, HIS47D, ILE174D, ILE180D, ILE182D, ILE279G, ILE316D, LEU177D, LEU235D, LEU305G, LEU306G, LYS188G, LYS239D, LYS239G, LYS242D, LYS242G, LYS276G, LYS307G, MET246D, MET246G, MET275G, MET281G, MET314D, MET320D, MET326D, PHE210G, PHE263G, PHE46D, PRO232D, PRO237D, PRO310D, PRO310G, SER179D, SER243D, SER243G, SER248G, THR214D, THR277G, THR308G, THR311D, THR311G, THR315D, THR317D, TRP247G, TYR176D, TYR240D, TYR240G, TYR284G, VAL187G, VAL230D, VAL234D, VAL251G
• D-J: ALA129D, ALA129J, ARG131D, ARG131J, ARG278D, ARG280D, ARG280J, ASN266J, GLN96D, GLN96J, GLY130J, GLY274D, GLY274J, ILE271D, LYS276D, LYS276J, LYS77D, LYS77J, MET275D, MET281D, MET94J, PRO273D, PRO273J, SER272D, THR277D, THR277J, TYR128D, TYR128J
• D-K: ALA231K, ARG185D, ARG278D, ARG280D, ARG303D, ARG313D, ARG313K, ASN181K, ASN304K, ASN321K, ASP186D, ASP241D, ASP245D, CYS244D, GLN175K, GLN283D, GLN312D, GLN312K, GLU233K, GLU238K, GLU285D, GLU309D, GLU309K, GLU318K, GLY236K, GLY274D, GLY282D, HIS178K, HIS47K, ILE174K, ILE180K, ILE182K, ILE271D, ILE279D, ILE316K, LEU177K, LEU235K, LEU249D, LEU305D, LEU306D, LYS188D, LYS239D, LYS239K, LYS242K, LYS276D, LYS307D, LYS307K, MET246K, MET275D, MET281D, MET314K, MET320K, PHE210D, PHE263D, PRO232K, PRO237K, PRO273D, PRO310D, PRO310K, PRO44K, SER179K, SER243D, SER243K, SER248D, THR214K, THR215K, THR277D, THR308D, THR311D, THR311K, THR315K, THR317K, TRP247D, TYR176K, TYR240D, TYR240K, TYR284D, VAL187D, VAL230K, VAL234K, VAL251D
• E-F: ALA111F, ALA129E, ALA58E, ARG102F, ARG103F, ARG110F, ARG131E, ASN126E, ASN181F, ASN57E, ASP61E, ASP97E, CYS133E, GLN113F, GLN45F, GLN53E, GLN53F, GLN68E, GLN96E, GLU106F, GLU125E, GLU213F, GLY130E, GLY236F, GLY51F, HIS47F, ILE180F, ILE182F, ILE54E, ILE54F, ILE59E, ILE60E, ILE81E, LEU107F, LEU127E, LEU135E, LEU235F, LEU52F, LEU79E, LEU92E, LYS132E, LYS49F, LYS55E, LYS56E, LYS56F, LYS64E, LYS77E, MET94E, PHE46F, PRO44F, SER112F, SER179F, SER50F, SER67E, THR214F, THR215F, THR66E, TRP109F, TYR124E, TYR128E, TYR176F, TYR63E, VAL48F, VAL65E
• E-J: ALA231E, ARG185J, ARG278J, ARG280J, ARG303J, ARG313E, ARG313J, ARG348J, ASN181E, ASN266J, ASN304E, ASN304J, ASN321E, ASP186J, ASP241J, ASP245J, CYS244J, GLN175E, GLN283J, GLN312E, GLN312J, GLU190J, GLU233E, GLU238E, GLU285J, GLU309E, GLU309J, GLU318E, GLY236E, GLY274J, GLY282J, HIS178E, HIS47E, ILE174E, ILE180E, ILE182E, ILE252J, ILE255J, ILE279J, ILE316E, ILE74J, LEU177E, LEU235E, LEU249J, LEU305J, LEU306J, LYS188J, LYS239E, LYS242E, LYS276J, LYS307E, LYS307J, MET246E, MET246J, MET275J, MET281J, MET314E, MET320E, PHE147J, PHE210J, PHE263J, PRO189J, PRO227E, PRO232E, PRO237E, PRO261J, PRO262J, PRO310E, PRO310J, PRO44E, SER179E, SER243E, SER243J, SER248J, SER265J, THR214E, THR215E, THR277J, THR308J, THR311E, THR311J, THR315E, THR317E, TRP247J, TYR176E, TYR228E, TYR229E, TYR240E, TYR240J, TYR264J, TYR284J, VAL187J, VAL230E, VAL234E, VAL251J
• F-G: ALA129F, ALA129G, ARG131F, ARG131G, ARG278F, ARG278G, ARG280F, ARG280G, ASN266F, CYS133G, GLN96F, GLN96G, GLY130F, GLY130G, GLY274F, GLY274G, HIS267F, HIS267G, ILE271F, LEU79G, LYS276F, LYS276G, LYS77G, MET275G, MET281F, MET281G, MET94G, PRO273F, SER265F, SER272F, SER67G, THR277F, THR277G, TYR128F, TYR128G, VAL69G
• F-H: ALA231H, ARG185F, ARG278F, ARG280F, ARG303F, ARG313F, ARG313H, ARG348F, ASN181H, ASN191F, ASN266F, ASN304F, ASN304H, ASN321H, ASP186F, ASP241F, ASP245F, CYS244F, GLN175H, GLN283F, GLN312F, GLN312H, GLN45H, GLU190F, GLU233H, GLU238H, GLU285F, GLU309F, GLU309H, GLU318H, GLY236H, GLY274F, GLY282F, HIS178H, HIS267F, HIS47H, ILE174H, ILE180H, ILE182H, ILE252F, ILE255F, ILE271F, ILE279F, ILE316H, ILE74F, LEU177H, LEU235H, LEU249F, LEU305F, LEU306F, LYS188F, LYS239F, LYS239H, LYS242F, LYS242H, LYS276F, LYS307F, LYS307H, MET246F, MET275F, MET281F, MET314H, MET320H, MET326H, PHE147F, PHE210F, PHE263F, PHE46H, PRO189F, PRO227H, PRO232H, PRO261F, PRO262F, PRO273F, PRO310F, PRO310H, PRO44H, SER179H, SER243F, SER243H, SER248F, SER265F, SER272F, THR214H, THR215H, THR277F, THR308F, THR311F, THR311H, THR315H, THR317H, TRP247F, TYR176H, TYR228H, TYR229H, TYR240F, TYR240H, TYR264F, TYR284F, VAL187F, VAL230H, VAL234H, VAL251F
• G-H: ALA111H, ALA129G, ALA58G, ARG110H, ARG131G, ASN126G, ASN181H, ASN57G, ASP61G, CYS133G, GLN113H, GLN45H, GLN53G, GLN53H, GLU106H, GLU125G, GLU213H, GLY130G, GLY51H, HIS108H, HIS178H, HIS47H, ILE180H, ILE182H, ILE54G, ILE54H, ILE59G, ILE60G, ILE81G, LEU107H, LEU127G, LEU135G, LEU235H, LEU52H, LEU79G, LEU92G, LYS132G, LYS49H, LYS55G, LYS56G, LYS56H, LYS64G, LYS84G, MET94G, PHE46H, PRO44H, SER112H, SER179H, SER50H, SER67G, THR215H, THR66G, TRP109H, TYR124G, TYR128G, TYR176H, TYR63G, VAL48H, VAL65G
• G-I: ALA111G, ALA129I, ALA58I, ARG102G, ARG103G, ARG110G, ARG131I, ASN126I, ASN181G, ASN57I, ASP61I, ASP97I, CYS133I, GLN113G, GLN45G, GLN53G, GLN53I, GLU106G, GLU125I, GLU213G, GLY130I, GLY236G, GLY51G, HIS47G, ILE180G, ILE182G, ILE54G, ILE54I, ILE59I, ILE60I, ILE81I, LEU107G, LEU127I, LEU135I, LEU235G, LEU52G, LEU79I, LEU92I, LYS132I, LYS49G, LYS55I, LYS56G, LYS56I, LYS64I, LYS77I, LYS84I, MET94I, PHE43G, PHE46G, PHE82I, PRO237G, PRO44G, SER112G, SER179G, SER50G, SER67I, THR214G, THR215G, THR66I, TRP109G, TYR124I, TYR128I, TYR176G, TYR63I, VAL48G, VAL65I
• G-K: ALA231G, ARG185K, ARG278K, ARG280K, ARG303K, ARG313G, ARG313K, ASN181G, ASN304G, ASN304K, ASN321G, ASP186K, ASP241K, ASP245K, CYS244K, GLN175G, GLN283K, GLN312G, GLN312K, GLU190K, GLU233G, GLU238G, GLU285K, GLU309G, GLU309K, GLU318G, GLY236G, GLY274K, GLY282K, HIS178G, HIS47G, ILE174G, ILE180G, ILE182G, ILE255K, ILE279K, ILE316G, LEU177G, LEU235G, LEU249K, LEU305K, LEU306K, LYS188K, LYS239G, LYS239K, LYS242G, LYS276K, LYS307G, LYS307K, MET246K, MET275K, MET281K, MET314G, MET320G, PHE210K, PHE263K, PHE286K, PRO189K, PRO232G, PRO237G, PRO261K, PRO262K, PRO310G, PRO310K, PRO44G, SER179G, SER243G, SER243K, SER248K, SER265K, THR214G, THR215G, THR277K, THR308K, THR311G, THR311K, THR315G, THR317G, TRP247K, TYR176G, TYR240G, TYR240K, TYR284K, VAL187K, VAL230G, VAL234G, VAL251K
• H-I: ALA111I, ALA129H, ALA58H, ARG102I, ARG110I, ARG131H, ASN126H, ASN181I, ASN57H, ASP61H, ASP97H, CYS133H, GLN113I, GLN45I, GLN53H, GLN53I, GLN96H, GLU106I, GLU125H, GLU213I, GLY130H, GLY51I, HIS108I, HIS47I, ILE180I, ILE182I, ILE54H, ILE54I, ILE59H, ILE60H, LEU107I, LEU127H, LEU135H, LEU235I, LEU52I, LEU92H, LYS132H, LYS49I, LYS55H, LYS56H, LYS56I, LYS64H, LYS84H, MET94H, PHE46I, SER112I, SER179I, SER50I, SER67H, THR214I, THR215I, THR66H, TRP109I, TYR124H, TYR128H, TYR176I, TYR63H, VAL105I, VAL48I, VAL65H
• I-K: ALA129I, ALA129K, ARG131I, ARG131K, ARG278I, ARG280I, ARG280K, ASN75K, CYS133K, GLN96I, GLN96K, GLY130I, GLY130K, GLY274I, GLY274K, GLY73K, ILE271I, ILE74K, LEU72K, LYS276I, LYS276K, LYS353I, LYS77I, LYS77K, MET275I, MET275K, MET356I, MET94K, PRO273I, SER272I, THR277I, THR277K, TYR128I, TYR128K
• I-L: ALA231L, ARG185I, ARG278I, ARG280I, ARG303I, ARG313I, ARG313L, ARG348I, ASN181L, ASN191I, ASN266I, ASN304I, ASN304L, ASN321L, ASP186I, ASP241I, ASP245I, ASP351I, CYS244I, GLN175L, GLN283I, GLN312I, GLN312L, GLU190I, GLU233L, GLU238L, GLU285I, GLU309I, GLU309L, GLU318L, GLU350I, GLU354I, GLU355I, GLY236L, GLY274I, GLY282I, HIS178L, HIS184I, HIS47L, ILE174L, ILE180L, ILE252I, ILE255I, ILE271I, ILE279I, ILE316L, ILE74I, LEU177L, LEU192I, LEU235L, LEU249I, LEU305I, LEU306I, LYS188I, LYS239I, LYS239L, LYS242I, LYS242L, LYS276I, LYS307I, LYS307L, MET246I, MET246L, MET275I, MET281I, MET314L, PHE147I, PHE210I, PHE263I, PHE286I, PHE43L, PHE46L, PRO189I, PRO227L, PRO232L, PRO237L, PRO261I, PRO262I, PRO273I, PRO310I, PRO310L, PRO44L, SER179L, SER243I, SER243L, SER248I, SER265I, SER272I, THR214L, THR215L, THR277I, THR308I, THR311I, THR311L, THR315L, THR317L, TRP247I, TYR176L, TYR228L, TYR229L, TYR240I, TYR240L, TYR260I, TYR264I, TYR284I, VAL187I, VAL230L, VAL234L, VAL251I, VAL352I
• J-K: ALA111K, ALA129J, ALA58J, ARG102K, ARG103K, ARG110K, ARG131J, ASN126J, ASN181K, ASN57J, ASP61J, ASP97J, CYS133J, GLN113K, GLN45K, GLN53J, GLN53K, GLN68J, GLU106K, GLU125J, GLU213K, GLY130J, GLY51K, HIS178K, HIS47K, ILE180K, ILE182K, ILE54J, ILE54K, ILE59J, ILE60J, ILE81J, LEU107K, LEU127J, LEU135J, LEU177K, LEU52K, LEU79J, LEU92J, LYS132J, LYS49K, LYS55J, LYS56J, LYS56K, LYS64J, MET94J, PHE46K, PRO44K, SER112K, SER179K, SER50K, SER67J, THR66J, TRP109K, TYR124J, TYR128J, TYR176K, TYR63J, VAL105K, VAL48K, VAL65J
• J-L: ALA111J, ALA129L, ALA58L, ARG102L, ARG110J, ARG131L, ASN126L, ASN181J, ASN57L, ASP61L, ASP97L, CYS133L, CYS98L, GLN113J, GLN45J, GLN53J, GLN53L, GLN68L, GLN96L, GLU106J, GLU125L, GLU213J, GLY130L, GLY51J, HIS108J, HIS178J, HIS217J, HIS47J, ILE180J, ILE182J, ILE54J, ILE54L, ILE59L, ILE60L, ILE81L, LEU107J, LEU127L, LEU135L, LEU177J, LEU52J, LEU79L, LEU92L, LYS100L, LYS132L, LYS242J, LYS49J, LYS55L, LYS56J, LYS56L, LYS64L, LYS77L, LYS84L, MET94L, PHE43J, PHE46J, PRO44J, PRO99L, SER112J, SER179J, SER216J, SER50J, SER67L, THR214J, THR215J, THR66L, TRP109J, TYR124L, TYR128L, TYR176J, VAL48J, VAL65L, VAL69L
• K-L: ALA111L, ALA129K, ALA58K, ARG102L, ARG110L, ARG131K, ASN126K, ASN181L, ASN57K, ASP61K, CYS133K, GLN113L, GLN42L, GLN45L, GLN53K, GLN53L, GLN68K, GLN80K, GLN96K, GLU106L, GLU125K, GLU213L, GLY130K, GLY51L, HIS178L, HIS47L, ILE180L, ILE182L, ILE54K, ILE54L, ILE59K, ILE60K, ILE81K, LEU107L, LEU127K, LEU135K, LEU52L, LEU79K, LEU92K, LYS132K, LYS49L, LYS55K, LYS56K, LYS56L, LYS64K, LYS77K, LYS84K, MET94K, PHE43L, PHE46L, PHE82K, PRO44L, SER112L, SER179L, SER50L, SER67K, THR66K, TRP109L, TYR124K, TYR128K, TYR176L, TYR63K, VAL105L, VAL48L, VAL65K, VAL69K