3K6S

structure of integrin alphaxbeta2 ectodomain

• Total interactions analyzed: 28
• Total true interactions: 12
• Strongest Interaction:
  • Chains: C-G
  • Int. Res.: 122
  • Norm. En. per Res.: -3.7524
• Hub Node: A(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-37.3202	-13.8061	-692.822	-743.9484	422	47	10	33161	6	118	113
A-C	-79.4501	-114.2348	-432.587	-626.2719	232	71	3	21485	10	61	54
A-E	-51.1752	-77.4428	-276.648	-405.266	119	32	9	13214	3	18	14
A-G	0.0	0.0	-78.3518	-78.3518	106	2	0	4332	0	11	7
B-C	0.0	0.0	-0.0004	-0.0004	2	0	0	1	0	0	0
C-D	-26.4319	-46.1292	-669.383	-741.9441	390	63	9	32451	7	103	103
C-E	-19.9942	1.2005	-101.798	-120.5917	132	10	0	5931	0	15	8
C-G	-66.6923	-85.9531	-305.147	-457.7925	122	49	9	13830	5	18	13
E-F	-24.4124	-81.628	-631.961	-738.0014	381	57	9	30982	6	107	99
E-G	-93.5549	-103.4575	-434.892	-631.9044	229	38	3	20354	10	56	54
E-H	0.0	0.0	-0.0003	-0.0003	2	0	0	1	0	0	0
G-H	-24.8301	-67.0674	-606.74	-698.6375	380	52	9	30487	5	105	99

Interface residues

• A-B: ALA1068A, ALA1072A, ALA210B, ALA248B, ALA255B, ALA286B, ALA290B, ALA316A, ALA333A, ALA351B, ALA405A, ALA441A, ALA489A, ALA504A, ALA505A, ALA550B, ALA568A, ALA661A, ALA736A, ALA738A, ALA814A, ALA855A, ARG1071A, ARG303B, ARG375B, ARG382A, ARG407A, ARG466B, ARG469A, ARG476B, ARG483A, ARG484A, ARG501A, ARG521B, ARG532B, ARG555B, ARG565B, ARG588A, ARG638B, ARG643B, ARG666A, ARG670A, ARG714A, ARG740A, ARG811A, ARG823A, ARG845A, ARG852A, ARG99A, ASN100A, ASN159B, ASN167B, ASN171B, ASN207B, ASN260B, ASN378A, ASN42A, ASN479B, ASN480B, ASN518B, ASN523B, ASN530A, ASN577B, ASN70A, ASN716A, ASN847A, ASN920A, ASN939A, ASN998A, ASP163B, ASP209B, ASP20A, ASP243B, ASP250B, ASP261B, ASP278B, ASP348B, ASP354B, ASP380A, ASP383A, ASP478B, ASP488A, ASP489B, ASP501B, ASP515B, ASP644B, ASP663A, ASP706A, ASP737A, ASP794A, ASP830A, CYS169B, CYS484B, CYS487A, CYS490B, CYS497B, CYS512B, CYS514B, CYS519B, CYS537B, CYS540B, CYS576B, CYS579B, CYS593B, CYS596B, CYS600B, CYS640B, CYS648B, CYS673B, CYS829A, CYS97A, GLN1066A, GLN1073A, GLN284B, GLN291A, GLN334A, GLN36A, GLN376A, GLN409A, GLN434A, GLN464B, GLN467A, GLN472A, GLN525B, GLN552B, GLN563A, GLN567A, GLN586B, GLN591B, GLN739A, GLN817A, GLN819A, GLU1067A, GLU1079A, GLU173B, GLU212B, GLU291B, GLU292A, GLU2B, GLU309B, GLU312A, GLU313B, GLU318A, GLU325B, GLU331A, GLU377A, GLU466A, GLU494A, GLU513B, GLU520B, GLU554B, GLU592B, GLU642B, GLU646B, GLU705A, GLU815A, GLU884A, GLU913A, GLU96A, GLY17A, GLY19A, GLY213B, GLY244B, GLY249B, GLY251B, GLY254B, GLY262B, GLY283B, GLY319A, GLY352A, GLY412A, GLY432A, GLY436A, GLY453B, GLY465B, GLY481A, GLY486B, GLY488B, GLY493A, GLY496A, GLY524B, GLY526A, GLY528B, GLY529B, GLY531B, GLY538B, GLY559B, GLY584B, GLY595B, GLY601B, GLY637B, GLY647B, GLY665A, GLY797A, GLY816A, GLY853A, GLY98A, HIS161B, HIS246B, HIS287B, HIS293A, HIS349B, HIS410A, HIS463A, HIS498B, HIS549A, HIS582B, HIS826A, HIS848A, HIS930A, HIS94A, HIS95A, ILE256B, ILE263A, ILE314A, ILE314B, ILE315B, ILE317A, ILE435A, ILE455B, ILE482B, ILE483B, ILE507B, ILE517B, ILE545A, ILE604B, ILE850A, LEU103A, LEU1063A, LEU118B, LEU155B, LEU165B, LEU208B, LEU215B, LEU253B, LEU257B, LEU285B, LEU289B, LEU311B, LEU487B, LEU491A, LEU496B, LEU587B, LEU589B, LEU667A, LEU75A, LEU77A, LEU825A, LEU827A, LEU849A, LEU919A, LEU941A, LYS1044A, LYS1080A, LYS152B, LYS164B, LYS172B, LYS252B, LYS288B, LYS306B, LYS310B, LYS311A, LYS313A, LYS477B, LYS505B, LYS539B, LYS602B, LYS636B, LYS641B, LYS750A, LYS818A, LYS917A, MET101A, MET219B, MET304B, MET332A, MET71A, PHE1069A, PHE157B, PHE245B, PHE247B, PHE298B, PHE315A, PHE328A, PHE337A, PHE439A, PHE617B, PHE742A, PHE851A, PHE915A, PHE921A, PRO1064A, PRO156B, PRO162B, PRO168B, PRO170B, PRO211B, PRO259B, PRO280B, PRO289A, PRO316B, PRO35A, PRO374B, PRO406A, PRO462A, PRO498A, PRO503B, PRO525A, PRO530B, PRO547A, PRO563B, PRO588B, PRO594B, PRO597B, PRO634B, PRO664A, PRO710A, PRO91A, SER116B, SER21A, SER281B, SER324A, SER325A, SER326A, SER327A, SER338A, SER384A, SER389A, SER437A, SER442A, SER467B, SER481B, SER485B, SER500B, SER546A, SER548A, SER549B, SER550A, SER583B, SER598B, SER605B, SER645B, SER668A, SER707A, SER72A, SER76A, SER809A, SER824A, SER831A, SER910A, SER911A, THR1074A, THR1075A, THR160B, THR258B, THR307B, THR312B, THR320A, THR323A, THR355A, THR411A, THR431A, THR433A, THR452B, THR463B, THR468A, THR499B, THR516B, THR557B, THR639B, THR709A, THR712A, THR743A, THR828A, THR916A, THR92A, TRP356A, TRP482A, TRP485A, TRP486A, TRP499A, TRP649B, TYR102A, TYR115B, TYR265A, TYR279B, TYR308B, TYR385A, TYR388A, TYR408A, TYR438A, TYR464A, TYR465A, TYR492A, TYR511B, TYR522B, TYR564A, TYR585B, TYR603B, TYR741A, TYR796A, TYR810A, TYR812A, TYR906A, TYR918A, VAL1077A, VAL154B, VAL158B, VAL282B, VAL351A, VAL379A, VAL430A, VAL490A, VAL502B, VAL540A, VAL578B, VAL674B, VAL708A, VAL813A, VAL908A, VAL909A, VAL93A
• A-C: ALA1006A, ALA1006C, ALA1051A, ALA1051C, ALA754A, ALA754C, ALA879A, ALA879C, ALA962A, ALA985A, ALA985C, ALA988A, ALA988C, ARG1010A, ARG1010C, ARG1012A, ARG1012C, ARG1071A, ARG1071C, ARG615A, ARG615C, ARG621A, ARG621C, ARG874A, ARG874C, ARG889A, ARG889C, ASN751A, ASN751C, ASN761A, ASN761C, ASN790A, ASN790C, ASN880A, ASN880C, ASN951A, ASN951C, ASN959A, ASN959C, ASP1002A, ASP1002C, ASP1014A, ASP1056A, ASP1056C, ASP755A, ASP755C, ASP760A, ASP760C, ASP791A, ASP791C, ASP873A, ASP873C, CYS1003A, CYS1003C, CYS1008A, CYS1008C, CYS620A, CYS620C, CYS752A, CYS752C, CYS758A, CYS758C, GLN1062A, GLN1062C, GLN1066A, GLN1066C, GLN1073C, GLN623A, GLN623C, GLN759A, GLN759C, GLN856A, GLN856C, GLN896A, GLN896C, GLN960A, GLN960C, GLU1052A, GLU1052C, GLU619A, GLU619C, GLU622A, GLU622C, GLU749A, GLU749C, GLU793A, GLU793C, GLU898A, GLU898C, GLU957A, GLU957C, GLU961A, GLU961C, GLU982A, GLU982C, GLY1007A, GLY1007C, GLY1065A, GLY1065C, GLY753A, GLY753C, GLY763A, GLY763C, GLY770A, GLY770C, GLY792A, GLY792C, GLY853A, GLY853C, GLY854A, GLY854C, HIS756A, HIS756C, ILE1005A, ILE1005C, ILE1053A, ILE1053C, ILE757A, ILE757C, ILE764A, ILE764C, ILE984A, ILE984C, LEU1009A, LEU1009C, LEU762A, LEU762C, LEU771A, LEU771C, LEU774A, LEU774C, LEU775A, LEU775C, LEU876A, LEU876C, LEU877A, LEU877C, LEU897A, LEU897C, LEU899A, LEU899C, LEU958A, LEU958C, LYS750C, LYS772A, LYS772C, LYS892A, LYS892C, LYS902A, LYS902C, LYS983A, LYS983C, MET1070A, MET1070C, MET787A, MET787C, PHE1011A, PHE1011C, PHE1055A, PHE1055C, PHE618A, PHE618C, PHE766A, PHE766C, PHE768A, PHE768C, PHE895A, PHE895C, PHE952A, PHE952C, PRO614A, PRO614C, PRO769A, PRO769C, PRO888A, PRO888C, PRO900A, PRO900C, PRO986A, PRO986C, PRO987A, PRO987C, SER1004A, SER1004C, SER1049C, SER1058A, SER1058C, SER1061A, SER1061C, SER616A, SER616C, SER765A, SER765C, SER767A, SER767C, SER773A, SER773C, SER891A, SER891C, SER949A, SER949C, SER989C, THR1054A, THR1054C, THR1057A, THR1057C, THR878A, THR878C, THR890A, THR890C, THR893A, THR893C, THR894A, THR894C, TRP789A, TRP789C, TRP953A, TRP953C, TYR1060A, TYR1060C, VAL1048C, VAL1050A, VAL1050C, VAL1059A, VAL1059C, VAL881A, VAL881C, VAL901A, VAL901C, VAL954C, VAL956A, VAL963A
• A-E: ALA611A, ALA611E, ALA617A, ALA691A, ALA691E, ALA726A, ALA726E, ARG650A, ARG650E, ARG683A, ARG683E, ARG685A, ARG685E, ARG728A, ARG728E, ASN634A, ASN634E, ASN695A, ASN695E, ASN697A, ASN697E, ASP651A, ASP651E, CYS636A, CYS636E, CYS693A, CYS693E, GLN607A, GLN607E, GLN628A, GLN628E, GLN632A, GLN632E, GLN653A, GLN653E, GLN674A, GLN674E, GLU612A, GLU612E, GLU627A, GLU627E, GLU675A, GLU675E, GLU694A, GLU694E, GLY648A, GLY648E, GLY688A, GLY688E, HIS692A, HIS692E, ILE609A, ILE609E, ILE635A, ILE635E, ILE639A, ILE639E, LEU630A, LEU630E, LEU637A, LEU637E, LEU647A, LEU647E, LEU652A, LEU652E, LEU687A, LEU687E, LEU689A, LEU689E, LEU698A, LEU698E, LEU699A, LEU699E, LEU700A, LEU724A, LEU724E, LEU725A, LEU725E, LYS690A, LYS690E, MET606A, MET606E, PHE608A, PHE608E, PHE696A, PHE696E, PRO610A, PRO610E, PRO614A, PRO614E, PRO723A, PRO723E, SER605A, SER605E, SER616E, SER626A, SER626E, SER633A, SER633E, SER649A, SER649E, SER654A, SER654E, SER655A, SER655E, THR629A, THR629E, TYR638A, TYR638E, VAL624A, VAL624E, VAL625A, VAL625E, VAL631A, VAL631E, VAL684A, VAL684E, VAL686A, VAL686E
• A-G: ALA26A, ALA26G, ARG1012A, ARG1012G, ARG422A, ARG422G, ARG978A, ARG978G, ASN1031A, ASN1031G, ASN27A, ASN27G, ASN974A, ASN974G, ASP447A, ASP449A, ASP451A, ASP451G, ASP966A, ASP966G, GLN114A, GLN114G, GLN399A, GLN577A, GLN577G, GLN85A, GLN85G, GLN973G, GLU928A, GLU928G, GLU968A, GLU968G, GLU982G, GLY1030A, GLY1030G, GLY111A, GLY111G, GLY452A, GLY452G, HIS930A, HIS930G, HIS971A, HIS971G, LEU1028G, LEU115A, LEU115G, LEU394A, LEU394G, LEU646A, LEU646G, LEU977G, LYS1029A, LYS1029G, LYS396A, LYS396G, LYS983A, LYS983G, MET367A, MET367G, MET933A, MET933G, MET965A, MET965G, PRO112A, PRO112G, PRO343A, PRO343G, PRO365A, PRO365G, PRO83A, PRO83G, PRO972A, PRO972G, PRO975A, PRO975G, SER28A, SER28G, SER450A, SER450G, SER82A, SER82G, SER84A, SER84G, SER929A, SER929G, SER970A, SER970G, SER976A, SER976G, SER981A, THR1027A, THR1027G, THR113A, THR113G, THR81A, THR81G, TRP29A, TRP29G, TYR25A, TYR25G, VAL931A, VAL931G, VAL967A, VAL967G, VAL969A, VAL969G
• B-C: GLN469B, SER989C
• C-D: ALA1068C, ALA1072C, ALA210D, ALA248D, ALA255D, ALA286D, ALA333C, ALA351D, ALA405C, ALA441C, ALA489C, ALA504C, ALA505C, ALA550D, ALA568C, ALA661C, ALA736C, ALA814C, ALA855C, ARG1071C, ARG303D, ARG375D, ARG382C, ARG407C, ARG469C, ARG476D, ARG484C, ARG501C, ARG521D, ARG532D, ARG555D, ARG565D, ARG588C, ARG638D, ARG643D, ARG666C, ARG670C, ARG679C, ARG714C, ARG740C, ARG811C, ARG823C, ARG845C, ARG852C, ARG99C, ASN100C, ASN159D, ASN207D, ASN260D, ASN42C, ASN479D, ASN480D, ASN518D, ASN523D, ASN530C, ASN562D, ASN577D, ASN70C, ASN716C, ASN790C, ASN847C, ASN920C, ASN939C, ASP163D, ASP209D, ASP20C, ASP243D, ASP250D, ASP261D, ASP278D, ASP348D, ASP383C, ASP41D, ASP478D, ASP488C, ASP489D, ASP501D, ASP515D, ASP644D, ASP663C, ASP706C, ASP737C, ASP794C, ASP830C, ASP864C, CYS3D, CYS484D, CYS487C, CYS490D, CYS497D, CYS512D, CYS514D, CYS519D, CYS527D, CYS535D, CYS537D, CYS540D, CYS560D, CYS581D, CYS593D, CYS596D, CYS600D, CYS640D, CYS648D, CYS673D, CYS829C, CYS97C, GLN1066C, GLN1073C, GLN1D, GLN284D, GLN334C, GLN36C, GLN409C, GLN434C, GLN45D, GLN467C, GLN495C, GLN525D, GLN552D, GLN563C, GLN567C, GLN586D, GLN591D, GLN739C, GLN817C, GLN937C, GLU1067C, GLU1079C, GLU212D, GLU291D, GLU2D, GLU309D, GLU313D, GLU331C, GLU466C, GLU494C, GLU513D, GLU520D, GLU554D, GLU558D, GLU592D, GLU642D, GLU646D, GLU705C, GLU815C, GLU884C, GLU913C, GLU96C, GLY17C, GLY18D, GLY19C, GLY213D, GLY244D, GLY249D, GLY251D, GLY254D, GLY262D, GLY283D, GLY352C, GLY412C, GLY432C, GLY436C, GLY486D, GLY488D, GLY493C, GLY496C, GLY524D, GLY526C, GLY538D, GLY559D, GLY584D, GLY595D, GLY601D, GLY637D, GLY647D, GLY665C, GLY797C, GLY816C, GLY853C, GLY98C, HIS161D, HIS246D, HIS287D, HIS410C, HIS463C, HIS498D, HIS538C, HIS549C, HIS582D, HIS826C, HIS848C, HIS912C, HIS930C, HIS94C, HIS95C, ILE256D, ILE314D, ILE315D, ILE435C, ILE482D, ILE483D, ILE507D, ILE517D, ILE604D, ILE850C, LEU103C, LEU1063C, LEU1078C, LEU155D, LEU165D, LEU208D, LEU215D, LEU253D, LEU257D, LEU285D, LEU289D, LEU311D, LEU487D, LEU491C, LEU496D, LEU561D, LEU587D, LEU589D, LEU667C, LEU75C, LEU77C, LEU825C, LEU827C, LEU849C, LEU919C, LEU941C, LYS1044C, LYS164D, LYS252D, LYS288D, LYS306D, LYS310D, LYS477D, LYS505D, LYS539D, LYS5D, LYS602D, LYS636D, LYS641D, LYS750C, LYS818C, LYS917C, MET101C, MET219D, MET304D, MET332C, MET71C, PHE1069C, PHE157D, PHE245D, PHE247D, PHE298D, PHE328C, PHE337C, PHE439C, PHE536D, PHE537C, PHE546D, PHE851C, PHE915C, PHE921C, PRO1064C, PRO156D, PRO162D, PRO168D, PRO170D, PRO19D, PRO211D, PRO259D, PRO280D, PRO316D, PRO35C, PRO374D, PRO406C, PRO44D, PRO462C, PRO498C, PRO503D, PRO525C, PRO547C, PRO563D, PRO588D, PRO594D, PRO597D, PRO664C, PRO710C, PRO91C, SER17D, SER21C, SER281D, SER326C, SER327C, SER338C, SER384C, SER389C, SER437C, SER481D, SER485D, SER500D, SER546C, SER548C, SER549D, SER550C, SER583D, SER598D, SER645D, SER668C, SER707C, SER72C, SER76C, SER809C, SER824C, SER831C, SER910C, SER911C, SER922C, THR1075C, THR1076C, THR160D, THR258D, THR307D, THR312D, THR355C, THR411C, THR42D, THR431C, THR433C, THR468C, THR499D, THR4D, THR516D, THR557D, THR639D, THR709C, THR712C, THR743C, THR828C, THR842C, THR907C, THR916C, THR92C, TRP356C, TRP486C, TRP499C, TRP649D, TYR102C, TYR279D, TYR308D, TYR385C, TYR388C, TYR408C, TYR438C, TYR464C, TYR465C, TYR492C, TYR508D, TYR511D, TYR522D, TYR564C, TYR585D, TYR741C, TYR796C, TYR810C, TYR812C, TYR906C, TYR918C, VAL1077C, VAL154D, VAL158D, VAL22C, VAL282D, VAL351C, VAL379C, VAL490C, VAL502D, VAL526D, VAL578D, VAL674D, VAL708C, VAL813C, VAL908C, VAL909C, VAL938C, VAL93C
• C-E: ALA26C, ALA26E, ARG1012E, ARG422C, ARG422E, ARG425C, ARG978C, ARG978E, ASN1031C, ASN1031E, ASN27C, ASN27E, ASN974C, ASN974E, ASP344C, ASP344E, ASP447C, ASP447E, ASP449C, ASP451C, ASP451E, ASP511C, ASP966C, ASP966E, GLN114C, GLN114E, GLN399C, GLN399E, GLN419E, GLN423C, GLN423E, GLN577C, GLN577E, GLN85C, GLN85E, GLN973C, GLN973E, GLU928C, GLU928E, GLU968C, GLU968E, GLY1030C, GLY1030E, GLY111C, GLY111E, GLY397C, GLY452C, GLY452E, HIS930E, HIS971C, HIS971E, LEU1028E, LEU115E, LEU362E, LEU392C, LEU394C, LEU394E, LEU646C, LEU977C, LEU977E, LYS1029C, LYS1029E, LYS396C, LYS516C, LYS983C, LYS983E, MET367C, MET367E, MET933C, MET933E, MET965C, MET965E, PRO1016E, PRO112C, PRO112E, PRO343C, PRO343E, PRO364C, PRO364E, PRO365C, PRO365E, PRO83C, PRO83E, PRO972C, PRO972E, PRO975C, PRO975E, SER1017E, SER28C, SER28E, SER368E, SER421C, SER421E, SER450C, SER450E, SER453C, SER82C, SER82E, SER84C, SER84E, SER929C, SER929E, SER970C, SER970E, SER976C, SER976E, SER980E, SER981C, THR1027E, THR113C, THR113E, THR342C, THR370C, THR370E, THR518C, THR80C, THR81C, THR81E, TRP29E, TRP395C, TRP424C, TRP424E, TYR25E, VAL398C, VAL420C, VAL420E, VAL931C, VAL931E, VAL967C, VAL967E, VAL969C, VAL969E
• C-G: ALA611C, ALA611G, ALA617C, ALA691C, ALA691G, ALA726C, ALA726G, ARG650C, ARG650G, ARG683C, ARG683G, ARG685C, ARG685G, ARG728C, ARG728G, ASN634C, ASN634G, ASN695C, ASN695G, ASN697C, ASN697G, ASP651C, ASP651G, CYS636C, CYS636G, CYS693C, CYS693G, GLN607C, GLN607G, GLN628C, GLN628G, GLN632C, GLN632G, GLN653C, GLN653G, GLN674C, GLN674G, GLU612C, GLU612G, GLU627C, GLU627G, GLU675C, GLU675G, GLU694C, GLU694G, GLY648C, GLY648G, GLY688C, GLY688G, HIS692C, HIS692G, ILE609C, ILE609G, ILE635C, ILE635G, ILE639C, ILE639G, LEU630C, LEU630G, LEU637C, LEU637G, LEU647C, LEU647G, LEU652C, LEU652G, LEU658C, LEU658G, LEU687C, LEU687G, LEU689C, LEU689G, LEU698C, LEU698G, LEU699C, LEU699G, LEU700C, LEU700G, LEU724C, LEU724G, LEU725C, LEU725G, LYS690C, LYS690G, MET606C, PHE608C, PHE608G, PHE696C, PHE696G, PHE727G, PRO610C, PRO610G, PRO614C, PRO614G, PRO723C, PRO723G, SER605C, SER605G, SER616C, SER626C, SER626G, SER633C, SER633G, SER649C, SER649G, SER654C, SER654G, SER655C, SER655G, THR629C, THR629G, TYR638C, TYR638G, VAL624C, VAL624G, VAL625C, VAL625G, VAL631C, VAL631G, VAL684C, VAL684G, VAL686C, VAL686G
• E-F: ALA1068E, ALA1072E, ALA210F, ALA248F, ALA255F, ALA286F, ALA290F, ALA333E, ALA351F, ALA405E, ALA441E, ALA489E, ALA504E, ALA505E, ALA550F, ALA568E, ALA661E, ALA736E, ALA738E, ALA814E, ALA855E, ARG1071E, ARG303F, ARG375F, ARG382E, ARG407E, ARG466F, ARG469E, ARG476F, ARG483E, ARG484E, ARG501E, ARG521F, ARG532F, ARG555F, ARG565F, ARG588E, ARG638F, ARG643F, ARG666E, ARG670E, ARG714E, ARG740E, ARG811E, ARG823E, ARG845E, ARG852E, ARG99E, ASN100E, ASN159F, ASN207F, ASN260F, ASN42E, ASN479F, ASN480F, ASN518F, ASN523F, ASN530E, ASN577F, ASN70E, ASN716E, ASN847E, ASN920E, ASN939E, ASP163F, ASP209F, ASP20E, ASP243F, ASP250F, ASP261F, ASP278F, ASP348F, ASP354F, ASP383E, ASP478F, ASP488E, ASP489F, ASP501F, ASP515F, ASP644F, ASP663E, ASP706E, ASP737E, ASP794E, ASP830E, ASP864E, CYS484F, CYS487E, CYS490F, CYS497F, CYS512F, CYS514F, CYS519F, CYS527F, CYS537F, CYS540F, CYS560F, CYS576F, CYS581F, CYS593F, CYS596F, CYS600F, CYS640F, CYS648F, CYS673F, CYS829E, CYS97E, GLN1066E, GLN1073E, GLN284F, GLN334E, GLN36E, GLN409E, GLN434E, GLN464F, GLN467E, GLN525F, GLN552F, GLN563E, GLN567E, GLN586F, GLN591F, GLN739E, GLN817E, GLN937E, GLU1067E, GLU1079E, GLU212F, GLU291F, GLU309F, GLU313F, GLU331E, GLU466E, GLU494E, GLU513F, GLU520F, GLU554F, GLU592F, GLU642F, GLU646F, GLU705E, GLU815E, GLU884E, GLU913E, GLU96E, GLY17E, GLY19E, GLY213F, GLY244F, GLY249F, GLY251F, GLY254F, GLY262F, GLY283F, GLY352E, GLY412E, GLY432E, GLY436E, GLY465F, GLY486F, GLY488F, GLY493E, GLY496E, GLY524F, GLY526E, GLY528F, GLY529F, GLY531F, GLY538F, GLY559F, GLY584F, GLY595F, GLY601F, GLY637F, GLY647F, GLY665E, GLY797E, GLY816E, GLY853E, GLY98E, HIS161F, HIS246F, HIS287F, HIS349F, HIS410E, HIS463E, HIS498F, HIS549E, HIS582F, HIS826E, HIS848E, HIS912E, HIS930E, HIS94E, HIS95E, ILE256F, ILE314F, ILE315F, ILE435E, ILE482F, ILE483F, ILE507F, ILE517F, ILE545E, ILE604F, ILE850E, LEU103E, LEU1063E, LEU1078E, LEU155F, LEU165F, LEU208F, LEU215F, LEU253F, LEU257F, LEU285F, LEU289F, LEU311F, LEU487F, LEU491E, LEU496F, LEU587F, LEU589F, LEU667E, LEU75E, LEU77E, LEU825E, LEU827E, LEU849E, LEU919E, LEU941E, LYS1044E, LYS1080E, LYS164F, LYS252F, LYS288F, LYS306F, LYS310F, LYS477F, LYS505F, LYS539F, LYS602F, LYS641F, LYS750E, LYS818E, LYS917E, MET101E, MET219F, MET304F, MET332E, MET71E, PHE1069E, PHE157F, PHE245F, PHE247F, PHE298F, PHE328E, PHE337E, PHE439E, PHE742E, PHE851E, PHE915E, PHE921E, PRO1064E, PRO156F, PRO162F, PRO168F, PRO211F, PRO259F, PRO280F, PRO316F, PRO35E, PRO374F, PRO406E, PRO462E, PRO498E, PRO503F, PRO525E, PRO530F, PRO547E, PRO563F, PRO588F, PRO594F, PRO597F, PRO664E, PRO710E, PRO91E, SER21E, SER281F, SER327E, SER338E, SER384E, SER389E, SER437E, SER467F, SER481F, SER485F, SER500F, SER546E, SER548E, SER549F, SER583F, SER598F, SER645F, SER668E, SER707E, SER72E, SER76E, SER809E, SER824E, SER831E, SER910E, SER911E, SER922E, THR1075E, THR1076E, THR160F, THR258F, THR307F, THR312F, THR355E, THR411E, THR431E, THR433E, THR463F, THR468E, THR499F, THR516F, THR557F, THR639F, THR709E, THR712E, THR743E, THR828E, THR907E, THR916E, THR92E, TRP356E, TRP482E, TRP485E, TRP486E, TRP499E, TRP649F, TYR102E, TYR279F, TYR308F, TYR385E, TYR388E, TYR408E, TYR438E, TYR464E, TYR465E, TYR492E, TYR508F, TYR511F, TYR522F, TYR564E, TYR585F, TYR741E, TYR796E, TYR810E, TYR812E, TYR906E, TYR918E, VAL1077E, VAL154F, VAL158F, VAL282F, VAL351E, VAL430E, VAL490E, VAL502F, VAL540E, VAL578F, VAL674F, VAL708E, VAL813E, VAL908E, VAL909E, VAL938E, VAL93E
• E-G: ALA1006E, ALA1006G, ALA1051E, ALA1051G, ALA754E, ALA754G, ALA879E, ALA879G, ALA985E, ALA985G, ALA988E, ALA988G, ARG1010E, ARG1010G, ARG1012E, ARG1012G, ARG1071E, ARG1071G, ARG615E, ARG615G, ARG621E, ARG621G, ARG874E, ARG874G, ARG889E, ARG889G, ASN751E, ASN751G, ASN761E, ASN761G, ASN790E, ASN790G, ASN880E, ASN880G, ASN951E, ASN951G, ASN959E, ASN959G, ASP1002E, ASP1002G, ASP1014E, ASP1056E, ASP1056G, ASP755E, ASP755G, ASP760E, ASP760G, ASP791E, ASP791G, ASP873E, ASP873G, CYS1003E, CYS1003G, CYS1008E, CYS1008G, CYS620E, CYS620G, CYS752E, CYS752G, CYS758E, CYS758G, GLN1062E, GLN1062G, GLN1066E, GLN1066G, GLN1073E, GLN623E, GLN623G, GLN759E, GLN759G, GLN856E, GLN856G, GLN896E, GLN896G, GLN960E, GLN960G, GLU1052E, GLU1052G, GLU619E, GLU619G, GLU622E, GLU622G, GLU749E, GLU749G, GLU793E, GLU793G, GLU898E, GLU898G, GLU957E, GLU957G, GLU961E, GLU961G, GLU982E, GLU982G, GLY1007E, GLY1007G, GLY1065E, GLY1065G, GLY753E, GLY753G, GLY763E, GLY763G, GLY770E, GLY770G, GLY792E, GLY792G, GLY853E, GLY853G, GLY854E, GLY854G, HIS756E, HIS756G, ILE1005E, ILE1005G, ILE1053E, ILE1053G, ILE757E, ILE757G, ILE764E, ILE764G, ILE950E, ILE984E, ILE984G, LEU1009E, LEU762E, LEU762G, LEU771E, LEU771G, LEU774E, LEU774G, LEU775E, LEU775G, LEU876E, LEU876G, LEU877E, LEU877G, LEU897E, LEU897G, LEU899E, LEU899G, LEU958E, LEU958G, LYS772E, LYS772G, LYS892E, LYS892G, LYS902E, LYS902G, LYS983E, LYS983G, MET1070E, MET1070G, MET787E, MET787G, PHE1011E, PHE1055E, PHE1055G, PHE618E, PHE618G, PHE766E, PHE766G, PHE768E, PHE768G, PHE895E, PHE895G, PHE952E, PHE952G, PRO614E, PRO614G, PRO769E, PRO769G, PRO888E, PRO888G, PRO900E, PRO900G, PRO986E, PRO986G, PRO987E, PRO987G, SER1004E, SER1004G, SER1049E, SER1058E, SER1058G, SER1061E, SER1061G, SER616E, SER616G, SER765E, SER765G, SER767E, SER767G, SER773E, SER773G, SER891E, SER891G, SER949E, SER949G, SER989E, THR1054E, THR1054G, THR1057E, THR1057G, THR878E, THR878G, THR890E, THR890G, THR893E, THR893G, THR894E, THR894G, TRP789E, TRP789G, TRP953E, TRP953G, TYR1060E, TYR1060G, VAL1048E, VAL1050E, VAL1050G, VAL1059E, VAL1059G, VAL624E, VAL624G, VAL788E, VAL881E, VAL881G, VAL901E, VAL901G
• E-H: GLN469H, SER989E
• G-H: ALA1068G, ALA1072G, ALA210H, ALA248H, ALA255H, ALA286H, ALA290H, ALA333G, ALA351H, ALA405G, ALA441G, ALA489G, ALA504G, ALA505G, ALA550H, ALA568G, ALA661G, ALA738G, ALA814G, ALA855G, ARG1071G, ARG303H, ARG375H, ARG382G, ARG407G, ARG466H, ARG469G, ARG476H, ARG483G, ARG484G, ARG501G, ARG521H, ARG532H, ARG555H, ARG565H, ARG588G, ARG638H, ARG643H, ARG666G, ARG670G, ARG714G, ARG740G, ARG811G, ARG823G, ARG845G, ARG852G, ARG99G, ASN100G, ASN159H, ASN207H, ASN260H, ASN42G, ASN479H, ASN480H, ASN518H, ASN523H, ASN530G, ASN577H, ASN70G, ASN716G, ASN847G, ASN920G, ASN939G, ASP163H, ASP209H, ASP20G, ASP243H, ASP250H, ASP261H, ASP278H, ASP348H, ASP383G, ASP478H, ASP488G, ASP489H, ASP501H, ASP515H, ASP644H, ASP663G, ASP706G, ASP737G, ASP794G, ASP830G, ASP864G, CYS484H, CYS487G, CYS490H, CYS497H, CYS512H, CYS514H, CYS519H, CYS537H, CYS540H, CYS560H, CYS576H, CYS581H, CYS590H, CYS593H, CYS596H, CYS600H, CYS640H, CYS648H, CYS673H, CYS829G, CYS97G, GLN1066G, GLN1073G, GLN284H, GLN334G, GLN36G, GLN409G, GLN434G, GLN464H, GLN467G, GLN525H, GLN552H, GLN563G, GLN567G, GLN586H, GLN591H, GLN739G, GLN817G, GLN937G, GLU1067G, GLU1079G, GLU212H, GLU291H, GLU309H, GLU313H, GLU331G, GLU377G, GLU466G, GLU513H, GLU520H, GLU554H, GLU592H, GLU642H, GLU646H, GLU705G, GLU815G, GLU884G, GLU913G, GLU96G, GLY17G, GLY19G, GLY213H, GLY244H, GLY249H, GLY251H, GLY254H, GLY262H, GLY283H, GLY352G, GLY412G, GLY432G, GLY436G, GLY465H, GLY481G, GLY486H, GLY488H, GLY524H, GLY526G, GLY529H, GLY531H, GLY538H, GLY559H, GLY584H, GLY595H, GLY601H, GLY637H, GLY647H, GLY665G, GLY797G, GLY816G, GLY853G, GLY98G, HIS161H, HIS246H, HIS287H, HIS349H, HIS410G, HIS463G, HIS498H, HIS582H, HIS826G, HIS848G, HIS912G, HIS930G, HIS94G, HIS95G, ILE256H, ILE314H, ILE315H, ILE435G, ILE455H, ILE482H, ILE483H, ILE507H, ILE517H, ILE545G, ILE604H, ILE850G, LEU103G, LEU1063G, LEU155H, LEU165H, LEU208H, LEU215H, LEU253H, LEU257H, LEU285H, LEU289H, LEU311H, LEU409H, LEU487H, LEU491G, LEU496H, LEU587H, LEU589H, LEU667G, LEU75G, LEU77G, LEU825G, LEU827G, LEU849G, LEU919G, LEU941G, LYS1044G, LYS1080G, LYS152H, LYS164H, LYS252H, LYS288H, LYS306H, LYS310H, LYS477H, LYS505H, LYS539H, LYS602H, LYS636H, LYS641H, LYS750G, LYS818G, LYS917G, MET101G, MET219H, MET304H, MET332G, MET71G, PHE1069G, PHE157H, PHE245H, PHE247H, PHE298H, PHE328G, PHE337G, PHE439G, PHE742G, PHE851G, PHE915G, PHE921G, PRO1064G, PRO156H, PRO162H, PRO168H, PRO211H, PRO259H, PRO280H, PRO316H, PRO35G, PRO374H, PRO406G, PRO462G, PRO498G, PRO503H, PRO525G, PRO530H, PRO547G, PRO563H, PRO588H, PRO594H, PRO597H, PRO634H, PRO664G, PRO710G, PRO91G, SER21G, SER281H, SER326G, SER327G, SER338G, SER384G, SER389G, SER437G, SER442G, SER467H, SER481H, SER485H, SER500H, SER546G, SER548G, SER549H, SER583H, SER598H, SER645H, SER668G, SER707G, SER72G, SER76G, SER809G, SER824G, SER831G, SER910G, SER911G, THR1074G, THR1075G, THR1076G, THR160H, THR258H, THR307H, THR312H, THR355G, THR411G, THR431G, THR433G, THR463H, THR468G, THR499H, THR516H, THR639H, THR709G, THR712G, THR743G, THR828G, THR916G, THR92G, TRP356G, TRP482G, TRP485G, TRP486G, TRP499G, TRP649H, TYR102G, TYR279H, TYR308H, TYR385G, TYR388G, TYR408G, TYR438G, TYR464G, TYR465G, TYR492G, TYR511H, TYR522H, TYR564G, TYR585H, TYR741G, TYR796G, TYR810G, TYR812G, TYR906G, TYR918G, VAL1077G, VAL154H, VAL158H, VAL22G, VAL282H, VAL351G, VAL379G, VAL490G, VAL502H, VAL540G, VAL578H, VAL674H, VAL708G, VAL813G, VAL908G, VAL909G, VAL938G, VAL93G