3K55

structure of beta hairpin deletion mutant of beta toxin from staphylococcus aureus

• Total interactions analyzed: 120
• Total true interactions: 31
• Strongest Interaction:
  • Chains: A-B
  • Int. Res.: 234
  • Norm. En. per Res.: -6.646
• Hub Node: A(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-340.9017	-80.9688	-1133.29	-1555.1605	234	70	29	40721	8	75	75
A-C	0.0	0.0	-49.7038	-49.7038	67	4	1	3281	0	6	11
A-D	0.0	3.8564	-57.0046	-53.1482	49	2	0	3348	0	30	20
A-K	0.0	0.0	-7.561	-7.561	9	0	0	475	0	2	1
A-L	0.0	0.0	-0.007	-0.007	2	0	0	1	0	0	1
B-C	-7.4553	1.8799	-57.8476	-63.423	55	13	0	3736	0	33	22
B-E	0.0	0.0	-0.0115	-0.0115	4	0	0	13	0	1	1
B-K	-27.1427	13.414	-160.982	-174.7107	90	45	10	8169	0	28	29
B-L	0.0	0.0	-8.1387	-8.1387	10	0	0	433	0	2	1
C-D	-302.6295	-60.6084	-1134.77	-1498.0079	231	86	28	41297	8	77	74
C-E	-4.5796	1.58	-25.3898	-28.3894	48	29	0	3133	1	14	10
C-J	0.0	-12.8814	-34.2598	-47.1412	48	6	0	2369	0	16	17
D-J	-25.5731	-2.9156	137.14	108.6513	21	56	0	1957	0	7	4
E-F	-280.1634	-54.4049	-1113.89	-1448.4583	235	64	29	40507	8	80	79
E-H	-3.8056	1.3462	-23.9986	-26.4581	41	8	0	1799	0	18	14
E-O	0.0	0.0	-1.2893	-1.2893	13	0	0	266	0	4	3
F-G	-4.135	2.23	-36.8831	-38.7881	48	4	0	2573	0	25	18
F-H	0.0	0.0	-48.7248	-48.7248	69	2	1	3158	0	6	11
G-H	-289.7511	-64.3154	-1112.13	-1466.1965	231	63	29	40261	8	77	77
G-M	0.0	0.0	-4.3788	-4.3788	7	0	0	364	0	2	1
H-M	0.0	1.5705	-46.475	-44.9045	61	2	3	3268	0	16	21
H-N	0.0	0.0	-2.31	-2.31	4	0	0	239	0	1	1
I-J	-296.538	-67.7983	-1087.94	-1452.2763	232	75	28	39750	8	76	72
J-O	0.0	6.5972	-25.0116	-18.4144	57	22	0	2424	0	13	13
K-L	-316.3815	-92.8614	-736.309	-1145.5519	231	82	28	38886	8	72	70
M-N	-312.5149	-75.5147	-1085.58	-1473.6095	231	72	28	39183	8	74	72
M-O	0.0	0.0	-3.4291	-3.4291	5	0	0	239	0	2	1
M-P	0.0	0.0	-0.0723	-0.0723	2	0	0	5	0	0	1
N-O	-5.6891	0.6837	-66.8463	-71.8517	66	5	7	4162	0	18	20
N-P	0.0	0.0	-10.961	-10.961	8	1	0	479	0	2	1
O-P	-259.1807	-54.3887	-1051.14	-1364.7094	233	84	28	38804	7	74	68

Interface residues

• A-B: ALA219A, ALA219B, ALA233A, ALA233B, ALA283A, ALA283B, ALA34A, ALA34B, ALA59A, ARG33A, ARG33B, ASN16A, ASN16B, ASN196A, ASN196B, ASN222A, ASN230A, ASN230B, ASN236A, ASN236B, ASN262A, ASN262B, ASN273A, ASN273B, ASN27A, ASN27B, ASN45A, ASN45B, ASN46A, ASN46B, ASN52A, ASN52B, ASN66A, ASN66B, ASP194A, ASP194B, ASP226A, ASP226B, ASP246A, ASP246B, ASP274A, ASP274B, ASP277A, ASP277B, ASP35A, ASP35B, ASP47A, ASP47B, ASP7B, ASP9A, ASP9B, GLN228A, GLN228B, GLN256A, GLN256B, GLN259A, GLN259B, GLN30A, GLN30B, GLN39A, GLN39B, GLU243A, GLU243B, GLU263A, GLU263B, GLU267A, GLU267B, GLU53A, GLU53B, GLY192A, GLY192B, GLY193A, GLY193B, GLY220A, GLY220B, GLY29A, GLY29B, GLY38A, GLY38B, HIS150A, HIS150B, HIS15A, HIS15B, HIS221A, HIS221B, HIS244A, HIS244B, HIS278A, HIS278B, ILE232A, ILE232B, ILE248A, ILE248B, ILE281A, ILE281B, ILE37A, ILE37B, ILE43A, ILE43B, ILE50A, ILE50B, LEU10A, LEU10B, LEU12A, LEU12B, LEU195A, LEU195B, LEU20A, LEU20B, LEU217A, LEU217B, LEU245A, LEU245B, LEU260A, LEU260B, LEU36A, LEU36B, LEU63B, LYS11A, LYS11B, LYS234A, LYS234B, LYS258A, LYS258B, LYS268A, LYS268B, LYS270A, LYS270B, LYS282A, LYS282B, LYS286A, LYS286B, LYS32A, LYS32B, LYS44A, LYS44B, LYS62A, LYS62B, MET19A, MET19B, PHE249A, PHE249B, PHE275A, PHE275B, PHE51A, PHE51B, PRO227A, PRO227B, PRO242A, PRO242B, PRO257A, PRO257B, PRO269A, PRO269B, PRO26A, PRO26B, PRO271A, PRO271B, PRO280A, PRO280B, SER14A, SER14B, SER153A, SER153B, SER223A, SER223B, SER229A, SER229B, SER231A, SER231B, SER276A, SER276B, SER285A, SER285B, SER40A, SER40B, SER41A, SER41B, THR188A, THR188B, THR224A, THR224B, THR250A, THR250B, THR266A, THR266B, THR8A, THR8B, TRP225A, TRP225B, TRP272A, TRP272B, TRP28A, TRP28B, TYR18A, TYR18B, TYR190A, TYR190B, TYR218A, TYR218B, TYR235A, TYR235B, TYR237A, TYR237B, TYR247A, TYR247B, TYR279A, TYR279B, TYR284A, TYR284B, TYR31A, TYR31B, TYR42A, TYR42B, TYR71A, TYR71B, VAL13A, VAL13B, VAL17A, VAL17B, VAL197A, VAL197B, VAL216A, VAL216B, VAL261A, VAL261B, VAL264A, VAL264B, VAL265A, VAL265B, VAL48A, VAL48B, VAL49A, VAL49B
• A-C: ALA59A, ALA59C, ALA97A, ALA97C, ARG80A, ARG80C, ASN57A, ASN57C, ASP56A, ASP56C, ASP61A, ASP61C, ASP99A, ASP99C, GLN74A, GLN74C, GLN82A, GLN82C, GLU98A, GLU98C, GLY58A, GLY58C, GLY84A, GLY84C, LEU24A, LEU24C, LEU63A, LEU63C, LEU64A, LEU64C, LYS113A, LYS113C, LYS62A, LYS62C, LYS68A, LYS68C, PRO76A, PRO76C, SER21A, SER21C, SER60A, SER60C, SER65A, SER65C, SER81A, SER81C, SER83A, SER83C, SER93A, SER93C, SER94A, SER94C, THR22A, THR75A, THR75C, THR95A, THR95C, TYR31A, TYR31C, TYR92A, TYR92C, VAL23A, VAL23C, VAL77A, VAL77C, VAL96A, VAL96C
• A-D: ALA160A, ASN126A, ASN129A, ASN140D, ASN66D, ASP125A, ASP127A, ASP163A, ASP7D, CYS122A, CYS158A, GLN170A, GLN39D, GLU138D, GLU169A, GLU70D, GLY121A, GLY123A, GLY141D, GLY159A, GLY161A, GLY38D, GLY90A, HIS162A, ILE166A, LYS107D, LYS119A, LYS130A, LYS139D, LYS142D, LYS165A, LYS44D, LYS68D, LYS69D, PHE118A, PRO109D, PRO72D, SER120A, SER128A, SER91A, SER93A, SER94A, THR95A, TYR108D, TYR71D, TYR73D, TYR92A, VAL117A, VAL96A
• A-K: ASN214K, ASP215K, GLN259K, LEU217K, LYS258K, LYS286A, SER285A, TYR284A, VAL216K
• A-L: LYS286A, LYS286L
• B-C: ALA160C, ALA97C, ARG157C, ASN126C, ASN129C, ASN140B, ASN45B, ASN66B, ASP127C, ASP163C, ASP7B, CYS122C, CYS158C, GLN39B, GLU138B, GLU169C, GLU173C, GLU70B, GLU98C, GLY121C, GLY123C, GLY141B, GLY159C, GLY161C, GLY38B, GLY90C, HIS162C, ILE137B, ILE166C, LYS107B, LYS111B, LYS119C, LYS130C, LYS139B, LYS142B, LYS165C, LYS44B, LYS68B, LYS69B, PHE118C, PHE124C, PRO109B, PRO72B, SER120C, SER128C, SER91C, SER93C, SER94C, THR95C, TYR108B, TYR71B, TYR73B, TYR92C, VAL117C, VAL96C
• B-E: ASP7B, LYS142B, LYS234E, PRO238E
• B-K: ALA219B, ALA219K, ASN198B, ASN198K, ASN222B, ASN222K, ASN239B, ASN239K, ASN262B, ASN262K, ASP215B, ASP215K, ASP226B, ASP226K, GLN228B, GLN228K, GLN259B, GLN259K, GLU243B, GLU243K, GLU263B, GLU263K, GLU267B, GLU267K, GLY200B, GLY200K, GLY220B, GLY220K, GLY240B, GLY240K, HIS221B, HIS221K, HIS244B, HIS244K, LEU208B, LEU208K, LEU217B, LEU217K, LEU245B, LEU245K, LEU260B, LEU260K, LYS199B, LYS199K, LYS205B, LYS205K, LYS234B, LYS234K, LYS241B, LYS241K, LYS258B, LYS258K, LYS268K, PHE204B, PHE204K, PRO202B, PRO202K, PRO227B, PRO227K, PRO238B, PRO238K, PRO242B, PRO242K, SER223B, SER223K, SER229B, SER229K, THR201B, THR201K, THR224B, THR224K, THR266B, THR266K, TRP225B, TRP225K, TYR218B, TYR218K, TYR237B, TYR237K, TYR247B, TYR247K, VAL197B, VAL197K, VAL216B, VAL216K, VAL261B, VAL261K, VAL264B, VAL264K, VAL265K
• B-L: GLN259B, GLY200B, LEU217B, LEU260B, LYS258B, LYS286L, SER285L, TYR279L, TYR284L, VAL216B
• C-D: ALA219C, ALA219D, ALA233C, ALA233D, ALA283C, ALA283D, ALA34C, ALA34D, ALA59C, ARG33C, ARG33D, ASN16C, ASN16D, ASN196C, ASN196D, ASN222C, ASN230C, ASN230D, ASN236C, ASN236D, ASN262C, ASN262D, ASN273C, ASN273D, ASN27C, ASN27D, ASN45C, ASN45D, ASN46C, ASN46D, ASN52C, ASN52D, ASN66C, ASN66D, ASP194C, ASP194D, ASP226C, ASP226D, ASP246C, ASP246D, ASP274C, ASP274D, ASP277C, ASP277D, ASP35C, ASP35D, ASP47C, ASP47D, ASP7D, ASP9C, ASP9D, GLN228C, GLN228D, GLN256C, GLN256D, GLN259C, GLN259D, GLN30C, GLN30D, GLN39C, GLN39D, GLU243C, GLU243D, GLU263C, GLU263D, GLU267C, GLU267D, GLU53C, GLU53D, GLY192C, GLY192D, GLY193C, GLY193D, GLY220C, GLY220D, GLY29C, GLY29D, GLY38C, GLY38D, HIS150C, HIS150D, HIS15C, HIS15D, HIS221C, HIS221D, HIS244C, HIS244D, HIS278C, HIS278D, ILE232C, ILE232D, ILE248C, ILE248D, ILE281C, ILE281D, ILE37C, ILE37D, ILE43C, ILE43D, ILE50C, ILE50D, LEU10C, LEU10D, LEU12C, LEU12D, LEU195C, LEU195D, LEU20C, LEU20D, LEU217C, LEU217D, LEU245C, LEU245D, LEU260C, LEU260D, LEU36C, LEU36D, LYS11C, LYS11D, LYS234C, LYS234D, LYS258C, LYS258D, LYS268C, LYS268D, LYS270C, LYS270D, LYS282C, LYS282D, LYS286C, LYS286D, LYS32C, LYS32D, LYS44C, LYS44D, LYS62C, LYS62D, MET19C, MET19D, PHE249C, PHE249D, PHE275C, PHE275D, PHE51D, PRO227C, PRO227D, PRO242C, PRO242D, PRO257C, PRO257D, PRO269C, PRO269D, PRO26C, PRO26D, PRO271C, PRO271D, PRO280C, PRO280D, SER14C, SER14D, SER153C, SER153D, SER223C, SER223D, SER229C, SER229D, SER231C, SER231D, SER276C, SER276D, SER285C, SER285D, SER40C, SER40D, SER41C, SER41D, THR188C, THR188D, THR224C, THR224D, THR250C, THR250D, THR266C, THR266D, THR8D, TRP225C, TRP225D, TRP272C, TRP272D, TRP28C, TRP28D, TYR18C, TYR18D, TYR190C, TYR190D, TYR218C, TYR218D, TYR235C, TYR235D, TYR237C, TYR237D, TYR247C, TYR247D, TYR279C, TYR279D, TYR284C, TYR284D, TYR31C, TYR31D, TYR42C, TYR42D, TYR71C, TYR71D, VAL13C, VAL13D, VAL17C, VAL17D, VAL197C, VAL197D, VAL216C, VAL216D, VAL261C, VAL261D, VAL264C, VAL264D, VAL265C, VAL265D, VAL48C, VAL48D, VAL49C, VAL49D
• C-E: ALA160C, ALA160E, ARG157C, ARG164E, ARG167E, ASN198E, ASN222C, ASN239C, ASN239E, ASP163C, ASP163E, ASP206E, ASP226C, CYS158C, GLN228C, GLN228E, GLU154C, GLU154E, GLU203E, GLU243C, GLU243E, GLY159C, GLY161C, GLY161E, GLY200E, GLY240C, GLY240E, HIS244E, LEU245E, LYS165E, LYS199E, LYS205E, LYS234C, LYS241C, LYS241E, PHE204E, PRO202E, PRO227C, PRO238C, PRO238E, PRO242C, PRO242E, SER156C, SER223E, SER229C, THR201E, TYR237C, VAL197E
• C-J: ALA160J, ALA219C, ARG157J, ASN214C, ASN236J, ASN239J, ASN262C, ASP155J, ASP163J, ASP186C, ASP7C, ASP9C, CYS158J, GLN256C, GLN259C, GLU154J, GLU187C, GLU243J, GLU263C, GLY159J, LEU10C, LEU12C, LEU20J, LEU217C, LEU24J, LEU260C, LYS11C, LYS139C, LYS142C, LYS185C, LYS241J, LYS255C, LYS258C, PHE124J, PRO238J, PRO257C, PRO26J, SER153J, SER156J, THR8C, TRP225J, TRP28J, TYR18J, TYR218C, TYR235J, TYR237J, TYR25J, VAL261C
• D-J: ALA283D, ALA97J, ARG157J, ASP125J, ASP127J, ASP155J, CYS158J, GLU154J, GLY123J, LEU20J, LEU24J, LYS282D, LYS286D, PHE124J, SER153J, SER156J, SER21J, SER285D, TYR237J, TYR25J, TYR284D
• E-F: ALA219E, ALA219F, ALA233E, ALA233F, ALA283E, ALA283F, ALA34E, ALA34F, ARG33E, ARG33F, ASN16E, ASN16F, ASN196E, ASN196F, ASN222F, ASN230E, ASN230F, ASN236E, ASN236F, ASN262E, ASN262F, ASN273E, ASN273F, ASN27E, ASN27F, ASN45E, ASN45F, ASN46E, ASN46F, ASN52E, ASN52F, ASN66E, ASN66F, ASP194E, ASP194F, ASP226E, ASP226F, ASP246E, ASP246F, ASP274E, ASP274F, ASP277E, ASP277F, ASP35E, ASP35F, ASP47E, ASP47F, ASP7E, ASP7F, ASP9E, ASP9F, GLN228E, GLN228F, GLN256E, GLN256F, GLN259E, GLN259F, GLN30E, GLN30F, GLN39E, GLN39F, GLU243E, GLU243F, GLU263E, GLU263F, GLU267E, GLU267F, GLU53E, GLU53F, GLY192E, GLY192F, GLY193E, GLY193F, GLY220E, GLY220F, GLY29E, GLY29F, GLY38E, GLY38F, HIS150E, HIS150F, HIS15E, HIS15F, HIS221E, HIS221F, HIS244E, HIS244F, HIS278E, HIS278F, ILE232E, ILE232F, ILE248E, ILE248F, ILE281E, ILE281F, ILE37E, ILE37F, ILE43E, ILE43F, ILE50E, ILE50F, LEU10E, LEU10F, LEU12E, LEU12F, LEU195E, LEU195F, LEU20E, LEU20F, LEU217E, LEU217F, LEU245E, LEU245F, LEU260E, LEU260F, LEU36E, LEU36F, LYS11E, LYS11F, LYS234E, LYS234F, LYS258E, LYS258F, LYS268E, LYS268F, LYS270E, LYS270F, LYS282E, LYS282F, LYS286E, LYS286F, LYS32E, LYS32F, LYS44E, LYS44F, LYS62E, LYS62F, LYS69F, MET19E, MET19F, PHE249E, PHE249F, PHE275E, PHE275F, PHE51E, PHE51F, PRO227E, PRO227F, PRO242E, PRO242F, PRO257E, PRO257F, PRO269E, PRO269F, PRO26E, PRO26F, PRO271E, PRO271F, PRO280E, PRO280F, SER14E, SER14F, SER153E, SER153F, SER223E, SER223F, SER229E, SER229F, SER231E, SER231F, SER276E, SER276F, SER285E, SER285F, SER40E, SER40F, SER41E, SER41F, SER65F, THR188E, THR188F, THR224E, THR224F, THR250E, THR250F, THR266E, THR266F, THR8E, THR8F, TRP225E, TRP225F, TRP272E, TRP272F, TRP28E, TRP28F, TYR18E, TYR18F, TYR190E, TYR190F, TYR218E, TYR218F, TYR235E, TYR235F, TYR237E, TYR237F, TYR247E, TYR247F, TYR279E, TYR279F, TYR284E, TYR284F, TYR31E, TYR31F, TYR42E, TYR42F, TYR71E, TYR71F, VAL13E, VAL13F, VAL17E, VAL17F, VAL197E, VAL197F, VAL216E, VAL216F, VAL261E, VAL261F, VAL264E, VAL264F, VAL265E, VAL265F, VAL48E, VAL48F, VAL49E, VAL49F
• E-H: ALA160H, ALA97H, ASN126H, ASN129H, ASN140E, ASN66E, ASP127H, CYS122H, GLN39E, GLU169H, GLU70E, GLY121H, GLY141E, GLY159H, GLY161H, GLY38E, GLY90H, HIS162H, ILE166H, LYS107E, LYS119H, LYS130H, LYS139E, LYS165H, LYS44E, LYS68E, LYS69E, PHE118H, PRO109E, PRO72E, SER120H, SER128H, SER91H, SER93H, SER94H, THR95H, TYR108E, TYR73E, TYR92H, VAL117H, VAL96H
• E-O: ALA160O, ARG157O, ASP7E, CYS158O, GLN256E, GLN259E, GLY159O, LYS142E, LYS255E, LYS258E, PHE124O, PRO257E, SER156O
• F-G: ALA160F, ALA97F, ASN126F, ASN129F, ASN140G, ASN66G, ASP125F, ASP127F, CYS122F, CYS158F, GLN39G, GLU138G, GLU169F, GLU70G, GLU98F, GLY121F, GLY123F, GLY141G, GLY159F, GLY161F, GLY38G, GLY90F, HIS162F, ILE166F, LYS107G, LYS119F, LYS130F, LYS139G, LYS142G, LYS165F, LYS44G, LYS68G, LYS69G, PHE118F, PRO109G, PRO72G, SER120F, SER128F, SER91F, SER93F, SER94F, THR95F, TYR108G, TYR71G, TYR73G, TYR92F, VAL117F, VAL96F
• F-H: ALA59F, ALA59H, ALA97F, ALA97H, ARG80F, ARG80H, ASN57F, ASN57H, ASP35H, ASP56F, ASP56H, ASP61F, ASP61H, ASP99F, ASP99H, GLN74F, GLN74H, GLN82F, GLN82H, GLU98F, GLU98H, GLY58F, GLY58H, GLY84F, GLY84H, LEU24F, LEU24H, LEU63F, LEU63H, LEU64F, LEU64H, LYS113F, LYS113H, LYS62F, LYS62H, LYS68F, LYS68H, PRO76F, PRO76H, SER21F, SER21H, SER60F, SER60H, SER65F, SER65H, SER81F, SER81H, SER83F, SER83H, SER93F, SER93H, SER94F, SER94H, THR22F, THR22H, THR75F, THR75H, THR95F, THR95H, TYR31F, TYR31H, TYR92F, TYR92H, VAL23F, VAL23H, VAL77F, VAL77H, VAL96F, VAL96H
• G-H: ALA219G, ALA219H, ALA233G, ALA233H, ALA283G, ALA283H, ALA34G, ALA34H, ARG33G, ARG33H, ASN16G, ASN16H, ASN196G, ASN196H, ASN222H, ASN230G, ASN230H, ASN236G, ASN236H, ASN262G, ASN262H, ASN273G, ASN273H, ASN27G, ASN27H, ASN45G, ASN45H, ASN46G, ASN46H, ASN52G, ASN52H, ASN66G, ASN66H, ASP194G, ASP194H, ASP226G, ASP226H, ASP246G, ASP246H, ASP274G, ASP274H, ASP277G, ASP277H, ASP35G, ASP35H, ASP47G, ASP47H, ASP7G, ASP9G, ASP9H, GLN228G, GLN228H, GLN256G, GLN256H, GLN259G, GLN259H, GLN30G, GLN30H, GLN39G, GLN39H, GLU243G, GLU243H, GLU263G, GLU263H, GLU267G, GLU267H, GLU53G, GLU53H, GLY192G, GLY192H, GLY193G, GLY193H, GLY220G, GLY220H, GLY29G, GLY29H, GLY38G, GLY38H, HIS150G, HIS150H, HIS15G, HIS15H, HIS221G, HIS221H, HIS244G, HIS244H, HIS278G, HIS278H, ILE232G, ILE232H, ILE248G, ILE248H, ILE281G, ILE281H, ILE37G, ILE37H, ILE43G, ILE43H, ILE50G, ILE50H, LEU10G, LEU10H, LEU12G, LEU12H, LEU195G, LEU195H, LEU20G, LEU20H, LEU217G, LEU217H, LEU245G, LEU245H, LEU260G, LEU260H, LEU36G, LEU36H, LYS11G, LYS11H, LYS234G, LYS234H, LYS258G, LYS258H, LYS268G, LYS268H, LYS270G, LYS270H, LYS282G, LYS282H, LYS286G, LYS286H, LYS32G, LYS32H, LYS44G, LYS44H, LYS62G, LYS62H, MET19G, MET19H, PHE249G, PHE249H, PHE275G, PHE275H, PHE51G, PHE51H, PRO227G, PRO227H, PRO242G, PRO242H, PRO257G, PRO257H, PRO269G, PRO269H, PRO26G, PRO26H, PRO271G, PRO271H, PRO280G, PRO280H, SER14G, SER14H, SER153G, SER153H, SER223G, SER223H, SER229G, SER229H, SER231G, SER231H, SER276G, SER276H, SER285G, SER285H, SER40G, SER40H, SER41G, SER41H, THR188G, THR188H, THR224G, THR224H, THR250G, THR250H, THR266G, THR266H, THR8G, TRP225G, TRP225H, TRP272G, TRP272H, TRP28G, TRP28H, TYR18G, TYR18H, TYR190G, TYR190H, TYR218G, TYR218H, TYR235G, TYR235H, TYR237G, TYR237H, TYR247G, TYR247H, TYR279G, TYR279H, TYR284G, TYR284H, TYR31G, TYR31H, TYR42G, TYR42H, TYR71G, TYR71H, VAL13G, VAL13H, VAL17G, VAL17H, VAL197G, VAL197H, VAL216G, VAL216H, VAL261G, VAL261H, VAL264G, VAL264H, VAL265G, VAL265H, VAL48G, VAL48H, VAL49G, VAL49H
• G-M: ASN214M, ASP215M, GLN259M, LEU217M, LYS286G, TYR284G, VAL216M
• H-M: ALA219H, ALA219M, ASN198H, ASN198M, ASN222H, ASN222M, ASN239H, ASN239M, ASN262M, ASP215H, ASP215M, ASP226H, ASP226M, GLN228H, GLN228M, GLN259H, GLN259M, GLU243H, GLU243M, GLU263M, GLY200H, GLY200M, GLY220H, GLY220M, GLY240H, GLY240M, HIS221H, HIS221M, HIS244H, HIS244M, LEU217H, LEU217M, LEU260H, LEU260M, LYS199H, LYS199M, LYS205H, LYS205M, LYS241H, LYS241M, PRO227H, PRO227M, PRO238H, PRO238M, PRO242H, PRO242M, SER223H, SER223M, SER229H, SER229M, THR201H, THR201M, THR224M, THR266H, THR266M, TYR218H, TYR218M, VAL216H, VAL216M, VAL261H, VAL261M
• H-N: GLN259H, LEU217H, LYS286N, TYR284N
• I-J: ALA219I, ALA219J, ALA233I, ALA233J, ALA283I, ALA283J, ALA34I, ALA34J, ARG33I, ARG33J, ASN16I, ASN16J, ASN196I, ASN196J, ASN222I, ASN222J, ASN230I, ASN230J, ASN236I, ASN236J, ASN262I, ASN262J, ASN273I, ASN273J, ASN27I, ASN27J, ASN45I, ASN45J, ASN46I, ASN46J, ASN52I, ASN52J, ASN66J, ASP194I, ASP194J, ASP226I, ASP226J, ASP246I, ASP246J, ASP274I, ASP274J, ASP277I, ASP277J, ASP35I, ASP35J, ASP47I, ASP47J, ASP7J, ASP9I, ASP9J, GLN228I, GLN228J, GLN256I, GLN256J, GLN259I, GLN259J, GLN30I, GLN30J, GLN39I, GLN39J, GLU243I, GLU243J, GLU263I, GLU263J, GLU267I, GLU267J, GLU53I, GLU53J, GLY192I, GLY192J, GLY193I, GLY193J, GLY220I, GLY220J, GLY29I, GLY29J, GLY38I, GLY38J, HIS150I, HIS150J, HIS15I, HIS15J, HIS221I, HIS221J, HIS244I, HIS244J, HIS278I, HIS278J, ILE232I, ILE232J, ILE248I, ILE248J, ILE281I, ILE281J, ILE37I, ILE37J, ILE43I, ILE43J, ILE50I, ILE50J, LEU10I, LEU10J, LEU12I, LEU12J, LEU195I, LEU195J, LEU20I, LEU20J, LEU217I, LEU217J, LEU245I, LEU245J, LEU260I, LEU260J, LEU36I, LEU36J, LYS11I, LYS11J, LYS234I, LYS234J, LYS258I, LYS258J, LYS268I, LYS268J, LYS270I, LYS270J, LYS282I, LYS282J, LYS286I, LYS286J, LYS32I, LYS32J, LYS44I, LYS44J, LYS62I, LYS62J, MET19I, MET19J, PHE249I, PHE249J, PHE275I, PHE275J, PHE51I, PHE51J, PRO227I, PRO227J, PRO242I, PRO242J, PRO257I, PRO257J, PRO269I, PRO269J, PRO26I, PRO26J, PRO271I, PRO271J, PRO280I, PRO280J, SER14I, SER14J, SER153I, SER153J, SER223I, SER223J, SER229I, SER229J, SER231I, SER231J, SER276I, SER276J, SER285I, SER285J, SER40I, SER40J, SER41I, SER41J, THR188I, THR188J, THR224I, THR224J, THR250I, THR250J, THR266I, THR266J, THR8I, THR8J, TRP225I, TRP225J, TRP272I, TRP272J, TRP28I, TRP28J, TYR18I, TYR18J, TYR190I, TYR190J, TYR218I, TYR218J, TYR235I, TYR235J, TYR237I, TYR237J, TYR247I, TYR247J, TYR279I, TYR279J, TYR284I, TYR284J, TYR31I, TYR31J, TYR42I, TYR42J, TYR71I, TYR71J, VAL13I, VAL13J, VAL17I, VAL17J, VAL197I, VAL197J, VAL216I, VAL216J, VAL261I, VAL261J, VAL264I, VAL264J, VAL265I, VAL265J, VAL48I, VAL48J, VAL49I, VAL49J
• J-O: ALA59O, ARG80J, ARG80O, ASN57J, ASN57O, ASN66J, ASP56O, ASP61J, ASP61O, ASP86J, ASP86O, GLN115O, GLN74J, GLN82J, GLN82O, GLY58J, GLY58O, GLY84J, GLY84O, LEU64J, LEU64O, LYS111J, LYS113J, LYS113O, LYS62J, LYS62O, LYS68J, LYS68O, LYS87J, LYS87O, PRO72J, PRO76J, PRO76O, SER60O, SER65J, SER65O, SER81J, SER81O, SER83J, SER83O, SER93O, SER94J, SER94O, THR75J, THR88J, THR88O, THR95O, TRP85J, TRP85O, TYR31J, TYR31O, TYR71J, TYR73J, TYR92O, VAL105J, VAL23O, VAL77O
• K-L: ALA219K, ALA219L, ALA233K, ALA233L, ALA283K, ALA283L, ALA34K, ALA34L, ARG33K, ARG33L, ASN16K, ASN16L, ASN196K, ASN196L, ASN222K, ASN230K, ASN230L, ASN236K, ASN236L, ASN262K, ASN262L, ASN273K, ASN273L, ASN27K, ASN27L, ASN45K, ASN45L, ASN46K, ASN46L, ASN52K, ASN52L, ASP194K, ASP194L, ASP226K, ASP226L, ASP246K, ASP246L, ASP274K, ASP274L, ASP277K, ASP277L, ASP35K, ASP35L, ASP47K, ASP47L, ASP7K, ASP7L, ASP9K, ASP9L, GLN228K, GLN228L, GLN256K, GLN256L, GLN259K, GLN259L, GLN30K, GLN30L, GLN39K, GLN39L, GLU243K, GLU243L, GLU263K, GLU263L, GLU267K, GLU267L, GLU53K, GLU53L, GLY192K, GLY192L, GLY193K, GLY193L, GLY220K, GLY220L, GLY29K, GLY29L, GLY38K, GLY38L, HIS150K, HIS150L, HIS15K, HIS15L, HIS221K, HIS221L, HIS244K, HIS244L, HIS278K, HIS278L, ILE232K, ILE232L, ILE248K, ILE248L, ILE281K, ILE281L, ILE37K, ILE37L, ILE43K, ILE43L, ILE50K, ILE50L, LEU10K, LEU10L, LEU12K, LEU12L, LEU195K, LEU195L, LEU20K, LEU20L, LEU217K, LEU217L, LEU245K, LEU245L, LEU260K, LEU260L, LEU36K, LEU36L, LEU63L, LYS11K, LYS11L, LYS234K, LYS234L, LYS258K, LYS258L, LYS268K, LYS268L, LYS270K, LYS270L, LYS282K, LYS282L, LYS286K, LYS286L, LYS32K, LYS32L, LYS44K, LYS44L, MET19K, MET19L, PHE249K, PHE249L, PHE275K, PHE275L, PHE51K, PHE51L, PRO227K, PRO227L, PRO242K, PRO242L, PRO257K, PRO257L, PRO269K, PRO269L, PRO26K, PRO26L, PRO271K, PRO271L, PRO280K, PRO280L, SER14K, SER14L, SER153K, SER153L, SER223K, SER223L, SER229K, SER229L, SER231K, SER231L, SER276K, SER276L, SER285K, SER285L, SER40K, SER40L, SER41K, SER41L, THR188K, THR188L, THR224K, THR224L, THR250K, THR250L, THR266K, THR266L, THR8K, THR8L, TRP225K, TRP225L, TRP272K, TRP272L, TRP28K, TRP28L, TYR18K, TYR18L, TYR190K, TYR190L, TYR218K, TYR218L, TYR235K, TYR235L, TYR237K, TYR237L, TYR247K, TYR247L, TYR25L, TYR279K, TYR279L, TYR284K, TYR284L, TYR31K, TYR31L, TYR42K, TYR42L, TYR71K, TYR71L, VAL13K, VAL13L, VAL17K, VAL17L, VAL197K, VAL197L, VAL216K, VAL216L, VAL261K, VAL261L, VAL264K, VAL264L, VAL265K, VAL265L, VAL48K, VAL48L, VAL49K, VAL49L
• M-N: ALA219M, ALA219N, ALA233M, ALA233N, ALA283M, ALA283N, ALA34M, ALA34N, ARG33M, ARG33N, ASN16M, ASN16N, ASN196M, ASN196N, ASN222M, ASN222N, ASN230M, ASN230N, ASN236M, ASN236N, ASN262M, ASN262N, ASN273M, ASN273N, ASN27M, ASN27N, ASN45M, ASN45N, ASN46M, ASN46N, ASN52M, ASN52N, ASP194M, ASP194N, ASP226M, ASP226N, ASP246M, ASP246N, ASP274M, ASP274N, ASP277M, ASP277N, ASP35M, ASP35N, ASP47M, ASP47N, ASP7N, ASP9M, ASP9N, GLN228M, GLN228N, GLN256M, GLN256N, GLN259M, GLN259N, GLN30M, GLN30N, GLN39M, GLN39N, GLU243M, GLU243N, GLU263M, GLU263N, GLU267M, GLU267N, GLU53M, GLU53N, GLY192M, GLY192N, GLY193M, GLY193N, GLY220M, GLY220N, GLY29M, GLY29N, GLY38M, GLY38N, HIS150M, HIS150N, HIS15M, HIS15N, HIS221M, HIS221N, HIS244M, HIS244N, HIS278M, HIS278N, ILE232M, ILE232N, ILE248M, ILE248N, ILE281M, ILE281N, ILE37M, ILE37N, ILE43M, ILE43N, ILE50M, ILE50N, LEU10M, LEU10N, LEU12M, LEU12N, LEU195M, LEU195N, LEU20M, LEU20N, LEU217M, LEU217N, LEU245M, LEU245N, LEU260M, LEU260N, LEU36M, LEU36N, LYS11M, LYS11N, LYS234M, LYS234N, LYS258M, LYS258N, LYS268M, LYS268N, LYS270M, LYS270N, LYS282M, LYS282N, LYS286M, LYS286N, LYS32M, LYS32N, LYS44M, LYS44N, LYS62M, LYS62N, MET19M, MET19N, PHE249M, PHE249N, PHE275M, PHE275N, PHE51M, PHE51N, PRO227M, PRO227N, PRO242M, PRO242N, PRO257M, PRO257N, PRO269M, PRO269N, PRO26M, PRO26N, PRO271M, PRO271N, PRO280M, PRO280N, SER14M, SER14N, SER153M, SER153N, SER223M, SER223N, SER229M, SER229N, SER231M, SER231N, SER276M, SER276N, SER285M, SER285N, SER40M, SER40N, SER41M, SER41N, THR188M, THR188N, THR224M, THR224N, THR250M, THR250N, THR266M, THR266N, THR8M, THR8N, TRP225M, TRP225N, TRP272M, TRP272N, TRP28M, TRP28N, TYR18M, TYR18N, TYR190M, TYR190N, TYR218M, TYR218N, TYR235M, TYR235N, TYR237M, TYR237N, TYR247M, TYR247N, TYR279M, TYR279N, TYR284M, TYR284N, TYR31M, TYR31N, TYR42M, TYR42N, TYR71M, TYR71N, VAL13M, VAL13N, VAL17M, VAL17N, VAL197M, VAL197N, VAL216M, VAL216N, VAL261M, VAL261N, VAL264M, VAL264N, VAL265M, VAL265N, VAL48M, VAL48N, VAL49M, VAL49N
• M-O: GLN259O, LEU217O, LYS258O, LYS286M, TYR284M
• M-P: LYS286M, LYS286P
• N-O: ALA219N, ALA219O, ASN198N, ASN198O, ASN222N, ASN222O, ASN239N, ASN239O, ASN262N, ASN262O, ASP215N, ASP215O, ASP226N, ASP226O, GLN228N, GLN228O, GLN259N, GLN259O, GLU243N, GLU243O, GLU263N, GLU263O, GLY200N, GLY200O, GLY220N, GLY220O, GLY240N, GLY240O, HIS221N, HIS221O, HIS244N, HIS244O, LEU217N, LEU217O, LEU260N, LEU260O, LYS199N, LYS199O, LYS205N, LYS205O, LYS241N, LYS241O, LYS268N, LYS268O, PHE204N, PHE204O, PRO202N, PRO202O, PRO242N, PRO242O, SER223N, SER223O, SER229N, SER229O, THR201N, THR201O, THR266N, THR266O, TYR218N, TYR218O, TYR247N, TYR247O, VAL216N, VAL216O, VAL261N, VAL261O
• N-P: GLN259N, LEU217N, LEU260N, LYS258N, LYS286P, SER285P, TYR284P, VAL216N
• O-P: ALA219O, ALA219P, ALA233O, ALA233P, ALA283O, ALA283P, ALA34O, ALA34P, ARG33O, ARG33P, ASN16O, ASN16P, ASN196O, ASN196P, ASN222O, ASN222P, ASN230O, ASN230P, ASN236O, ASN236P, ASN262O, ASN262P, ASN273O, ASN273P, ASN27O, ASN27P, ASN45O, ASN45P, ASN46O, ASN46P, ASN52O, ASN52P, ASP194O, ASP194P, ASP226O, ASP226P, ASP246O, ASP246P, ASP274O, ASP274P, ASP277O, ASP277P, ASP35O, ASP35P, ASP47O, ASP47P, ASP7O, ASP7P, ASP9O, ASP9P, GLN228O, GLN228P, GLN256O, GLN256P, GLN259O, GLN259P, GLN30O, GLN30P, GLN39O, GLN39P, GLU243O, GLU243P, GLU263O, GLU263P, GLU267O, GLU267P, GLU53O, GLU53P, GLY192O, GLY192P, GLY193O, GLY193P, GLY220O, GLY220P, GLY29O, GLY29P, GLY38O, GLY38P, HIS150O, HIS150P, HIS15O, HIS15P, HIS221O, HIS221P, HIS244O, HIS244P, HIS278O, HIS278P, ILE232O, ILE232P, ILE248O, ILE248P, ILE281O, ILE281P, ILE37O, ILE37P, ILE43O, ILE43P, ILE50O, ILE50P, LEU10O, LEU10P, LEU12O, LEU12P, LEU195O, LEU195P, LEU20O, LEU20P, LEU217O, LEU217P, LEU245O, LEU245P, LEU260O, LEU260P, LEU36O, LEU36P, LEU63O, LYS11O, LYS11P, LYS234O, LYS234P, LYS258O, LYS258P, LYS268O, LYS268P, LYS270O, LYS270P, LYS282O, LYS282P, LYS286O, LYS286P, LYS32O, LYS32P, LYS44O, LYS44P, LYS62O, LYS62P, MET19O, MET19P, PHE249O, PHE249P, PHE275O, PHE275P, PHE51O, PHE51P, PRO227O, PRO227P, PRO242O, PRO242P, PRO257O, PRO257P, PRO269O, PRO269P, PRO26O, PRO26P, PRO271O, PRO271P, PRO280O, PRO280P, SER14O, SER14P, SER153O, SER153P, SER223O, SER223P, SER229O, SER229P, SER231O, SER231P, SER276O, SER276P, SER285O, SER285P, SER40O, SER40P, SER41O, SER41P, THR188O, THR188P, THR224O, THR224P, THR250O, THR250P, THR266O, THR266P, THR8O, THR8P, TRP225O, TRP225P, TRP272O, TRP272P, TRP28O, TRP28P, TYR18O, TYR18P, TYR190O, TYR190P, TYR218O, TYR218P, TYR235O, TYR235P, TYR237O, TYR237P, TYR247O, TYR247P, TYR279O, TYR279P, TYR284O, TYR284P, TYR31O, TYR31P, TYR42O, TYR42P, TYR71O, TYR71P, VAL13O, VAL13P, VAL17O, VAL17P, VAL197O, VAL197P, VAL216O, VAL216P, VAL261O, VAL261P, VAL264O, VAL264P, VAL265O, VAL265P, VAL48O, VAL48P, VAL49O, VAL49P