3K4W

crystal structure of uncharacterized tim-barrel protein bb4693 from bordetella bronchiseptica

• Total interactions analyzed: 66
• Total true interactions: 26
• Strongest Interaction:
  • Chains: A-D
  • Int. Res.: 68
  • Norm. En. per Res.: -6.7144
• Hub Node: A(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-14.5856	13.1132	-245.935	-247.4074	85	10	2	9285	0	18	22
A-C	-25.2519	13.5407	-277.223	-288.9342	93	8	2	10211	0	17	23
A-D	-41.4237	-204.5962	-210.559	-456.5789	68	9	1	7683	14	54	40
A-E	-6.9558	0.0	-15.5528	-22.5086	22	0	1	741	0	4	2
B-C	-21.7347	15.4351	-233.188	-239.4875	89	7	2	8772	0	16	18
B-D	0.0	0.0	-16.2094	-16.2094	21	0	1	819	0	4	2
B-F	-41.8769	-199.3872	-204.945	-446.2091	67	8	1	7635	14	55	41
C-E	-44.1967	-151.3444	-197.897	-393.4381	67	5	1	7309	14	54	40
C-F	0.0	0.0	-1.9176	-1.9176	19	0	0	304	0	4	2
C-J	-9.3487	7.375	-91.4563	-93.4301	55	6	0	3802	0	13	16
D-E	-13.9394	15.2111	-245.222	-243.9503	88	2	1	8936	0	16	20
D-F	-26.428	16.3025	-278.053	-288.1785	96	5	2	10244	0	17	22
E-F	-34.3635	16.7958	-228.322	-245.8897	89	6	1	8703	0	18	19
F-G	0.0	6.3311	-0.5618	5.7693	9	0	0	118	0	10	10
F-H	0.0	-24.7584	-6.0065	-30.7649	21	0	0	482	1	9	12
F-J	-12.1615	-21.0133	-85.6408	-118.8156	67	7	1	4118	2	27	28
F-K	0.0	2.5643	-13.0119	-10.4476	19	0	0	725	0	9	10
G-H	-16.4674	16.1065	-233.583	-233.9439	88	6	2	8857	0	18	18
G-I	-25.0729	15.8537	-271.882	-281.1012	94	8	2	10265	0	18	27
H-I	-27.9353	16.2651	-234.125	-245.7952	89	5	1	8858	0	16	20
H-J	0.0	17.4251	-42.9739	-25.5488	39	2	0	2614	0	11	16
H-K	0.0	-0.9322	-1.0012	-1.9334	12	0	0	197	0	3	3
I-K	0.0	9.3206	-18.6795	-9.3589	28	0	0	908	0	10	11
J-K	-26.3339	15.0382	-240.634	-251.9297	86	3	2	8909	0	18	20
J-L	-17.8269	15.5803	-246.8	-249.0467	90	3	1	9113	0	18	19
K-L	-18.484	15.2305	-244.344	-247.5975	88	3	1	8974	0	17	20

Interface residues

• A-B: ALA160B, ALA201A, ALA222A, ALA222B, ALA227A, ARG174A, ARG203A, ARG204A, ARG235A, ARG29B, ARG32B, ASN159B, ASN168A, ASN168B, ASN190A, ASN190B, ASN217B, ASN229A, ASP134A, ASP163B, ASP173A, ASP178A, ASP223A, ASP223B, GLN195A, GLN195B, GLN226A, GLN33B, GLU170A, GLU170B, GLU196A, GLU196B, GLY125B, GLY157B, GLY158B, GLY161B, GLY177A, GLY220A, GLY220B, GLY35B, HIS132B, HIS171A, HIS171B, HIS199A, HIS221B, ILE164B, ILE172A, ILE197A, ILE197B, ILE198A, LEU215B, LEU218B, LEU232A, LEU34B, MET155B, MET213B, MET244B, PHE202A, PHE224A, PHE224B, PHE231A, PHE30B, PRO162B, PRO169A, PRO169B, PRO192B, PRO205A, PRO219A, PRO219B, SER230A, THR165B, THR167B, THR31B, TRP191B, TRP193A, TRP193B, TRP253B, TYR166B, TYR214B, TYR216B, VAL126B, VAL175A, VAL194A, VAL194B, VAL200A
• A-C: ALA160A, ALA201C, ALA222A, ALA222C, ALA227C, ARG174C, ARG19A, ARG203C, ARG204C, ARG235C, ARG27A, ARG29A, ARG32A, ASN159A, ASN168A, ASN168C, ASN190A, ASN190C, ASN206C, ASN217A, ASN229C, ASP134C, ASP163A, ASP173C, ASP178C, ASP223A, ASP223C, GLN195A, GLN195C, GLN226C, GLN33A, GLU170A, GLU170C, GLU196A, GLU196C, GLY125A, GLY157A, GLY158A, GLY161A, GLY177C, GLY220A, GLY220C, GLY35A, HIS132A, HIS171C, HIS199C, HIS221A, ILE164A, ILE172C, ILE197A, ILE197C, ILE198A, ILE198C, LEU176C, LEU207C, LEU215A, LEU218A, LEU232C, LEU34A, LEU72A, LYS260C, MET213A, MET244A, PHE202C, PHE224A, PHE224C, PHE231C, PHE30A, PHE36A, PRO162A, PRO169A, PRO169C, PRO192A, PRO205C, PRO219A, PRO219C, SER230C, THR165A, THR167A, THR31A, TRP191A, TRP193A, TRP193C, TRP253A, TYR166A, TYR214A, TYR216A, VAL126A, VAL175C, VAL194A, VAL194C, VAL200C, VAL71A
• A-D: ALA100A, ALA100D, ALA143A, ALA143D, ARG102A, ARG102D, ARG136A, ARG136D, ARG137A, ARG137D, ARG174A, ARG174D, ASN148A, ASN148D, ASP134A, ASP134D, ASP135A, ASP135D, ASP147A, ASP147D, ASP178A, ASP178D, ASP181A, ASP181D, CYS145A, CYS145D, GLU146A, GLU146D, GLU170A, GLU170D, GLY149A, GLY149D, GLY177A, GLY177D, HIS132A, HIS132D, HIS171A, HIS171D, LEU138A, LEU138D, LEU141A, LEU141D, LEU182A, LEU182D, LYS103A, LYS103D, MET106A, MET106D, MET131A, MET131D, PHE144A, PHE144D, PHE179A, PHE179D, PRO140A, PRO140D, PRO180A, PRO180D, THR101A, THR101D, TYR139A, TYR139D, TYR142A, TYR142D, VAL133A, VAL133D, VAL175A, VAL175D
• A-E: ALA100E, ALA128A, ALA128E, ARG136A, ARG136E, ARG137A, ARG137E, ASP163A, ASP163E, PRO130A, PRO130E, PRO162A, PRO162E, SER70A, THR129A, THR129E, THR165E, TRP127A, TRP127E, TYR166A, TYR166E, VAL71A
• B-C: ALA160C, ALA201B, ALA222B, ALA222C, ALA227B, ARG174B, ARG203B, ARG204B, ARG235B, ARG29C, ARG32C, ASN159C, ASN168B, ASN168C, ASN190B, ASN190C, ASN217C, ASN229B, ASP134B, ASP163C, ASP173B, ASP178B, ASP223B, ASP223C, GLN195B, GLN195C, GLN226B, GLN33C, GLU170B, GLU170C, GLU196B, GLU196C, GLY125C, GLY157C, GLY158C, GLY161C, GLY177B, GLY220B, GLY220C, GLY35C, HIS132C, HIS171B, HIS171C, HIS199B, HIS221C, ILE164C, ILE172B, ILE197B, ILE197C, ILE198B, ILE225B, LEU215C, LEU218C, LEU232B, LEU34C, LEU72C, LYS260B, MET155C, MET213C, MET244C, PHE202B, PHE224B, PHE224C, PHE231B, PHE30C, PRO162C, PRO169B, PRO169C, PRO192B, PRO192C, PRO205B, PRO219B, PRO219C, SER230B, THR165C, THR167C, THR31C, TRP191C, TRP193B, TRP193C, TRP253C, TYR166C, TYR214C, TYR216C, VAL126C, VAL175B, VAL194B, VAL194C, VAL200B
• B-D: ALA128B, ALA128D, ARG136B, ARG136D, ARG137B, ARG137D, ASP163B, ASP163D, MET131D, PRO130B, PRO130D, PRO162B, PRO162D, THR129B, THR129D, THR165B, THR165D, TRP127B, TRP127D, TYR166B, TYR166D
• B-F: ALA100B, ALA100F, ALA143B, ALA143F, ARG102B, ARG102F, ARG136B, ARG136F, ARG137B, ARG137F, ARG174B, ARG174F, ASN148B, ASN148F, ASP134B, ASP134F, ASP135B, ASP135F, ASP147B, ASP147F, ASP178B, ASP178F, ASP181B, ASP181F, CYS145B, CYS145F, GLU146B, GLU146F, GLU170B, GLU170F, GLY149B, GLY149F, GLY177B, GLY177F, HIS132B, HIS132F, HIS171B, HIS171F, LEU138B, LEU138F, LEU141B, LEU141F, LEU182B, LEU182F, LYS103B, LYS103F, MET106B, MET106F, MET131B, PHE144B, PHE144F, PHE179B, PHE179F, PRO140B, PRO140F, PRO180B, PRO180F, THR101B, THR101F, TYR139B, TYR139F, TYR142B, TYR142F, VAL133B, VAL133F, VAL175B, VAL175F
• C-E: ALA100C, ALA100E, ALA143C, ALA143E, ARG102C, ARG102E, ARG136C, ARG136E, ARG137C, ARG137E, ARG174C, ARG174E, ASN148C, ASN148E, ASP134C, ASP134E, ASP135C, ASP135E, ASP147C, ASP147E, ASP178C, ASP178E, ASP181C, ASP181E, CYS145C, CYS145E, GLU146C, GLU146E, GLU170C, GLU170E, GLY149C, GLY149E, GLY177C, GLY177E, HIS132C, HIS132E, HIS171C, HIS171E, LEU138C, LEU138E, LEU141C, LEU141E, LEU182C, LEU182E, LYS103C, LYS103E, MET106C, MET106E, MET131E, PHE144C, PHE144E, PHE179C, PHE179E, PRO140C, PRO140E, PRO180C, PRO180E, THR101C, THR101E, TYR139C, TYR139E, TYR142C, TYR142E, VAL133C, VAL133E, VAL175C, VAL175E
• C-F: ALA128C, ALA128F, ARG136C, ARG136F, ARG137C, ARG137F, ASP163C, ASP163F, PRO130C, PRO130F, PRO162C, PRO162F, THR129C, THR129F, THR165C, THR165F, TRP127C, TYR166C, VAL71F
• C-J: ALA128C, ALA12J, ALA18C, ALA78J, ALA81J, ALA82J, ALA84J, ALA86J, ARG19C, ARG23C, ARG67C, ASN17C, ASN68C, ASN77J, ASP114J, ASP25C, ASP79C, ASP79J, ASP89J, GLN108C, GLU104C, GLU111C, GLU111J, GLU48J, GLU98C, GLY116J, GLY14C, GLY14J, GLY73C, ILE26C, LEU115J, LEU16C, LEU16J, LEU47J, LEU72C, LYS45C, LYS85J, LYS90J, MET13C, MET13J, PHE51J, PRO24C, PRO88J, SER69C, SER70C, SER74C, SER76C, SER76J, THR22C, TYR21C, TYR87J, VAL71C, VAL75C, VAL80J, VAL83J
• D-E: ALA160E, ALA201D, ALA222D, ALA222E, ALA227D, ARG174D, ARG19E, ARG203D, ARG204D, ARG235D, ARG29E, ARG32E, ASN159E, ASN168D, ASN168E, ASN190D, ASN190E, ASN217E, ASN229D, ASP134D, ASP163E, ASP173D, ASP178D, ASP223D, ASP223E, GLN195D, GLN195E, GLN226D, GLN33E, GLU170D, GLU170E, GLU196D, GLU196E, GLY125E, GLY157E, GLY158E, GLY161E, GLY177D, GLY220D, GLY220E, GLY35E, HIS132E, HIS171D, HIS171E, HIS199D, HIS221E, ILE164E, ILE172D, ILE197D, ILE197E, ILE198D, ILE198E, LEU215E, LEU218E, LEU232D, LEU34E, MET155E, MET213E, MET244E, PHE202D, PHE224D, PHE224E, PHE231D, PHE30E, PRO162E, PRO169D, PRO169E, PRO192D, PRO192E, PRO205D, PRO219D, PRO219E, SER230D, THR165E, THR167E, THR31E, TRP191E, TRP193D, TRP193E, TRP253E, TYR166E, TYR214E, TYR216E, VAL126E, VAL175D, VAL194D, VAL194E, VAL200D
• D-F: ALA160D, ALA201F, ALA222D, ALA222F, ALA227F, ALA228F, ALA233F, ARG174F, ARG203F, ARG204F, ARG235F, ARG29D, ARG32D, ASN159D, ASN168D, ASN168F, ASN190D, ASN190F, ASN206F, ASN217D, ASN229F, ASP134F, ASP163D, ASP173F, ASP178F, ASP223D, ASP223F, GLN195D, GLN195F, GLN226F, GLN33D, GLU170D, GLU170F, GLU196D, GLU196F, GLY125D, GLY157D, GLY158D, GLY161D, GLY177F, GLY220D, GLY220F, GLY35D, HIS132D, HIS171D, HIS171F, HIS199F, HIS221D, ILE164D, ILE172F, ILE197D, ILE197F, ILE198D, ILE198F, ILE225F, ILE26D, LEU176F, LEU207F, LEU215D, LEU218D, LEU232F, LEU34D, LYS260F, MET155D, MET213D, MET244D, PHE202F, PHE224D, PHE224F, PHE231F, PHE30D, PHE36D, PRO162D, PRO169D, PRO169F, PRO192D, PRO192F, PRO205F, PRO219D, PRO219F, SER230F, THR165D, THR167D, THR31D, TRP191D, TRP193D, TRP193F, TRP253D, TYR166D, TYR214D, TYR216D, VAL126D, VAL175F, VAL194D, VAL194F, VAL200F
• E-F: ALA160F, ALA201E, ALA222E, ALA222F, ALA227E, ALA228E, ARG174E, ARG203E, ARG204E, ARG235E, ARG29F, ARG32F, ASN159F, ASN168E, ASN168F, ASN190E, ASN190F, ASN217F, ASN229E, ASP134E, ASP163F, ASP173E, ASP178E, ASP223E, ASP223F, GLN195E, GLN195F, GLN226E, GLN33F, GLU170E, GLU170F, GLU196E, GLU196F, GLY125F, GLY157F, GLY158F, GLY161F, GLY177E, GLY220E, GLY220F, GLY35F, HIS132F, HIS171E, HIS171F, HIS199E, HIS221F, ILE164F, ILE172E, ILE197E, ILE197F, ILE198E, ILE198F, ILE225E, LEU176E, LEU215F, LEU218F, LEU232E, LEU34F, MET213F, MET244F, PHE202E, PHE224E, PHE224F, PHE231E, PHE30F, PRO162F, PRO169E, PRO169F, PRO192E, PRO192F, PRO205E, PRO219E, PRO219F, SER230E, THR165F, THR167F, THR31F, TRP191F, TRP193E, TRP193F, TRP253F, TYR166F, TYR214F, TYR216F, VAL126F, VAL175E, VAL194E, VAL194F, VAL200E
• F-G: ASP262G, ASP89F, GLN61F, GLU273F, GLU60F, HIS269F, LYS260G, LYS2F, PRO261G
• F-H: ALA81F, ARG118F, ARG281F, ARG32H, ASP114F, GLN110F, GLU249H, GLU252H, GLU37H, GLU44H, GLY116F, GLY280F, LEU113F, LEU115F, LEU49H, LYS248H, LYS85F, PRO38H, PRO40H, THR256H, TRP253H
• F-J: ALA107F, ALA128F, ALA12F, ALA18F, ALA233J, ALA272J, ALA277J, ALA279J, ALA78F, ALA82F, ARG118J, ARG19F, ARG235J, ARG23F, ARG274J, ARG281J, ARG67F, ASN148J, ASN17F, ASN206J, ASN271J, ASN68F, ASN77F, ASP147J, ASP181J, ASP234J, ASP262J, ASP79F, GLN278J, GLU111F, GLU146J, GLU265J, GLU273J, GLY116J, GLY149J, GLY14F, GLY270J, GLY280J, GLY73F, HIS269J, ILE150J, LEU115F, LEU16F, LEU232J, LEU275J, LEU276J, LEU72F, LYS266J, LYS2J, LYS45F, LYS85F, MET13F, PHE15F, PHE231J, PRO151J, PRO205J, PRO24F, SER69F, SER70F, SER74F, SER76F, THR183J, THR22F, TYR208J, VAL71F, VAL75F, VAL80F
• F-K: ALA12F, ARG23K, ARG29K, ARG32K, ASN28K, ASP25K, GLU44F, GLU48F, GLU52F, ILE26K, LEU16F, LEU47F, LEU49F, LYS45F, MET13F, PRO11F, PRO24K, SER46F, TYR87F
• G-H: ALA160H, ALA201G, ALA222G, ALA222H, ALA227G, ARG174G, ARG203G, ARG204G, ARG235G, ARG29H, ARG32H, ASN159H, ASN168G, ASN168H, ASN190G, ASN190H, ASN217H, ASN229G, ASP134G, ASP163H, ASP173G, ASP178G, ASP223G, ASP223H, GLN195G, GLN195H, GLN226G, GLN33H, GLU170G, GLU170H, GLU196G, GLU196H, GLY125H, GLY157H, GLY158H, GLY161H, GLY177G, GLY220G, GLY220H, GLY35H, HIS132H, HIS171G, HIS171H, HIS199G, HIS221H, ILE164H, ILE172G, ILE197G, ILE197H, ILE198G, LEU176G, LEU215H, LEU218H, LEU232G, LEU34H, MET155H, MET213H, MET244H, PHE202G, PHE224G, PHE224H, PHE231G, PHE30H, PHE36H, PRO162H, PRO169G, PRO169H, PRO192G, PRO192H, PRO205G, PRO219G, PRO219H, SER230G, THR165H, THR167H, THR31H, TRP191H, TRP193G, TRP193H, TRP253H, TYR166H, TYR214H, TYR216H, VAL126H, VAL175G, VAL194G, VAL194H, VAL200G
• G-I: ALA160G, ALA201I, ALA222G, ALA222I, ALA227I, ARG174I, ARG19G, ARG203I, ARG204I, ARG235I, ARG27G, ARG29G, ARG32G, ASN159G, ASN168G, ASN168I, ASN190G, ASN190I, ASN206I, ASN217G, ASN229I, ASP134I, ASP163G, ASP173I, ASP178I, ASP223G, ASP223I, ASP234I, GLN195G, GLN195I, GLN226I, GLN33G, GLU170G, GLU170I, GLU196G, GLU196I, GLY125G, GLY157G, GLY158G, GLY161G, GLY177I, GLY220G, GLY220I, GLY35G, HIS132G, HIS171G, HIS171I, HIS199I, HIS221G, ILE164G, ILE172I, ILE197G, ILE197I, ILE198G, ILE198I, ILE26G, LEU207I, LEU215G, LEU218G, LEU232I, LEU34G, LYS260I, MET155G, MET213G, MET244G, PHE202I, PHE224G, PHE224I, PHE231I, PHE30G, PHE36G, PRO162G, PRO169G, PRO169I, PRO192G, PRO205I, PRO219G, PRO219I, SER230I, THR165G, THR167G, THR31G, TRP191G, TRP193G, TRP193I, TRP253G, TYR166G, TYR214G, TYR216G, VAL126G, VAL175I, VAL194G, VAL194I, VAL200I
• H-I: ALA160I, ALA201H, ALA222H, ALA222I, ALA227H, ARG174H, ARG19I, ARG203H, ARG204H, ARG235H, ARG29I, ARG32I, ASN159I, ASN168H, ASN168I, ASN190H, ASN190I, ASN217I, ASN229H, ASP134H, ASP163I, ASP173H, ASP178H, ASP223H, ASP223I, GLN195H, GLN195I, GLN226H, GLN33I, GLU170H, GLU170I, GLU196H, GLU196I, GLY125I, GLY157I, GLY158I, GLY161I, GLY177H, GLY220H, GLY220I, GLY35I, HIS132I, HIS171H, HIS171I, HIS199H, HIS221I, ILE164I, ILE172H, ILE197H, ILE197I, ILE198H, ILE198I, LEU176H, LEU215I, LEU218I, LEU232H, LEU34I, LEU72I, LYS260H, MET213I, MET244I, PHE202H, PHE224H, PHE224I, PHE231H, PHE30I, PRO162I, PRO169H, PRO169I, PRO192H, PRO192I, PRO205H, PRO219H, PRO219I, SER230H, THR165I, THR167I, THR31I, TRP191I, TRP193H, TRP193I, TYR166I, TYR214I, TYR216I, VAL126I, VAL175H, VAL194H, VAL194I, VAL200H
• H-J: ALA263J, ALA55H, ALA56H, ALA57H, ASN229J, ASP262J, GLU252H, GLU265H, GLU265J, GLU52H, GLU53H, GLU60H, GLY58H, HIS269H, ILE225J, ILE259J, ILE3H, ILE59H, LEU1H, LEU1J, LEU247H, LEU255H, LEU255J, LEU257J, LEU268H, LEU268J, LYS248H, LYS260J, LYS266J, LYS2H, MET264H, MET264J, MET54H, PRO258J, PRO261J, THR251H, THR256H, THR256J, TRP253J
• H-K: ASN217K, ASN229H, ASP262H, GLU249K, GLU252K, GLU37K, LYS260H, PRO258H, PRO261H, THR256K, TRP253K, TYR216K
• I-K: ALA55K, ALA56K, ALA57K, ASN217I, GLU249I, GLU252I, GLU252K, GLU37I, GLU52K, GLU53K, GLU60K, GLY58K, ILE259I, ILE59K, LEU1K, LEU255I, LEU257I, LEU49K, LYS248I, LYS248K, LYS2K, MET54K, PHE51K, PRO258I, PRO261K, THR256I, TRP253I, TYR216I
• J-K: ALA160K, ALA201J, ALA222J, ALA222K, ALA227J, ARG174J, ARG203J, ARG204J, ARG235J, ARG29K, ARG32K, ASN159K, ASN168J, ASN168K, ASN190K, ASN217K, ASN229J, ASP134J, ASP163K, ASP173J, ASP178J, ASP223J, ASP223K, GLN195J, GLN195K, GLN226J, GLN33K, GLU170J, GLU170K, GLU196J, GLU196K, GLY125K, GLY157K, GLY158K, GLY161K, GLY177J, GLY220J, GLY220K, GLY35K, HIS132K, HIS171J, HIS171K, HIS199J, HIS221K, ILE164K, ILE172J, ILE197J, ILE197K, ILE198J, LEU176J, LEU215K, LEU218K, LEU232J, LEU34K, LYS260J, MET213K, MET244K, PHE202J, PHE224J, PHE224K, PHE231J, PHE30K, PRO162K, PRO169J, PRO169K, PRO192J, PRO192K, PRO205J, PRO219J, PRO219K, SER230J, THR165K, THR167K, THR31K, TRP191K, TRP193J, TRP193K, TRP253K, TYR166K, TYR214K, TYR216K, VAL126K, VAL175J, VAL194J, VAL194K, VAL200J
• J-L: ALA160J, ALA201L, ALA222J, ALA222L, ALA227L, ALA228L, ARG174L, ARG203L, ARG204L, ARG235L, ARG29J, ARG32J, ASN159J, ASN168J, ASN168L, ASN190J, ASN190L, ASN217J, ASN229L, ASP134L, ASP163J, ASP173L, ASP178L, ASP223J, ASP223L, GLN195J, GLN195L, GLN226L, GLN33J, GLU170J, GLU170L, GLU196J, GLU196L, GLY125J, GLY157J, GLY158J, GLY161J, GLY177L, GLY220J, GLY220L, GLY35J, HIS132J, HIS171J, HIS171L, HIS199L, HIS221J, ILE164J, ILE172L, ILE197J, ILE197L, ILE198J, ILE198L, ILE225L, LEU176L, LEU215J, LEU218J, LEU232L, LEU34J, LYS260L, MET155J, MET213J, MET244J, PHE202L, PHE224J, PHE224L, PHE231L, PHE30J, PRO162J, PRO169J, PRO169L, PRO192J, PRO205L, PRO219J, PRO219L, SER230L, THR165J, THR167J, THR31J, TRP191J, TRP193J, TRP193L, TRP253J, TYR166J, TYR214J, TYR216J, VAL126J, VAL175L, VAL194J, VAL194L, VAL200L
• K-L: ALA160L, ALA201K, ALA222K, ALA222L, ALA227K, ARG174K, ARG203K, ARG204K, ARG235K, ARG29L, ARG32L, ASN159L, ASN168K, ASN168L, ASN190K, ASN190L, ASN217L, ASN229K, ASP134K, ASP163L, ASP173K, ASP178K, ASP223K, ASP223L, GLN195K, GLN195L, GLN226K, GLN33L, GLU170K, GLU170L, GLU196K, GLU196L, GLY125L, GLY157L, GLY158L, GLY161L, GLY177K, GLY220K, GLY220L, GLY35L, HIS132L, HIS171K, HIS171L, HIS199K, HIS221L, ILE164L, ILE172K, ILE197K, ILE197L, ILE198K, ILE198L, LEU176K, LEU215L, LEU218L, LEU232K, LEU34L, MET155L, MET213L, MET244L, PHE202K, PHE224K, PHE224L, PHE231K, PHE30L, PRO162L, PRO169K, PRO169L, PRO192K, PRO192L, PRO205K, PRO219K, PRO219L, SER230K, THR165L, THR167L, THR31L, TRP191L, TRP193K, TRP193L, TRP253L, TYR166L, TYR214L, TYR216L, VAL126L, VAL175K, VAL194K, VAL194L, VAL200K