3K4G

crystal structure of e. coli rna polymerase alpha subunit c-terminal domain

• Total interactions analyzed: 28
• Total true interactions: 14
• Strongest Interaction:
  • Chains: E-F
  • Int. Res.: 73
  • Norm. En. per Res.: -6.3937
• Hub Node: A(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-101.5486	-4.3895	-326.016	-431.9541	73	15	14	11769	0	10	11
A-C	0.0	13.9861	-6.0086	7.9775	30	0	0	347	0	6	14
A-D	-15.3905	-53.098	-43.1198	-111.6083	39	1	0	2045	2	16	15
B-C	-27.0307	-31.2289	-73.0979	-131.3575	42	2	0	2915	4	14	8
B-D	0.0	0.0	-5.4337	-5.4337	23	0	0	213	0	3	8
C-D	-118.5513	-0.7216	-334.025	-453.2979	73	14	14	12008	0	11	11
C-E	-16.531	-36.2312	-44.5009	-97.2631	37	2	1	2058	5	4	4
C-F	-9.1912	3.9572	-32.2306	-37.4646	17	4	0	964	0	2	7
E-F	-107.3968	-5.9101	-353.434	-466.7409	73	13	14	12120	0	11	12
E-G	-26.1965	-20.5559	-72.0545	-118.8069	41	6	0	3029	2	14	7
E-H	-7.3061	0.0	-2.388	-9.6941	21	1	0	215	0	1	8
F-G	0.0	13.2828	-4.7292	8.5536	30	0	0	326	0	5	13
F-H	0.0	38.724	-37.3204	1.4036	34	0	0	1799	0	14	15
G-H	-92.282	0.7334	-329.098	-420.6466	73	13	14	11804	0	10	11

Interface residues

• A-B: ALA274A, ALA274B, ALA324A, ALA324B, ALA327A, ALA327B, ARG255A, ARG255B, ARG310A, ARG310B, ARG317A, ARG317B, ASN320A, ASN320B, ASP250A, ASP250B, ASP280A, ASP280B, ASP328A, ASP328B, GLN283A, GLN283B, GLU248A, GLU248B, GLU319A, GLU319B, GLU329A, GLY279A, GLY279B, GLY311A, GLY311B, HIS276A, HIS276B, ILE252A, ILE252B, ILE275A, ILE275B, ILE278A, ILE278B, ILE326A, ILE326B, LEU253A, LEU253B, LEU254A, LEU254B, LEU312A, LEU312B, LEU318A, LEU318B, MET316A, MET316B, PHE249A, PHE249B, PRO247A, PRO247B, PRO251A, PRO251B, PRO256A, PRO256B, PRO322A, PRO322B, PRO323A, PRO323B, SER313A, SER313B, SER325A, SER325B, TRP321A, TRP321B, TYR277A, TYR277B, VAL282A, VAL282B
• A-C: ALA274A, ALA274C, ALA324A, ALA324C, ALA327A, ALA327C, ARG284A, ARG284C, ASN320A, ASN320C, ASP328A, ASP328C, GLN283C, GLU273A, GLU273C, GLU288A, GLU288C, GLU319A, GLU319C, GLU329A, GLU329C, PHE249C, PRO247A, PRO322A, PRO322C, SER325A, THR292A, THR292C, TRP321A, TRP321C
• A-D: ALA274A, ALA274D, ARG284A, ARG284D, ARG317A, ARG317D, ASN320A, ASN320D, ASP280A, ASP280D, GLN283A, GLN283D, GLU273A, GLU273D, GLU288A, GLU288D, GLU319A, GLU319D, GLY279A, GLY279D, GLY315A, GLY315D, ILE275A, ILE275D, LEU289A, LEU289D, LEU318A, LEU318D, PRO322A, PRO322D, PRO323A, PRO323D, SER325D, THR285A, THR285D, TRP321A, TRP321D, VAL287A, VAL287D
• B-C: ALA274B, ALA274C, ALA324C, ARG284B, ARG284C, ARG317B, ARG317C, ASN320B, ASN320C, ASP280B, ASP280C, GLN283B, GLN283C, GLU273B, GLU273C, GLU288B, GLU288C, GLU319B, GLU319C, GLY279B, GLY279C, GLY315B, GLY315C, ILE275B, ILE275C, LEU281C, LEU289B, LEU289C, LEU318B, LEU318C, MET316B, MET316C, PRO322B, PRO322C, PRO323B, PRO323C, THR285B, THR285C, TRP321B, TRP321C, VAL282B, VAL282C
• B-D: ALA274D, ALA324B, ALA324D, ALA327B, ALA327D, ARG284B, ARG284D, ASN320B, ASN320D, ASP328B, ASP328D, GLN283B, GLU288B, GLU319B, GLU319D, PHE249B, PHE249D, PRO247D, PRO322B, PRO322D, SER325D, TRP321B, TRP321D
• C-D: ALA274C, ALA274D, ALA324C, ALA324D, ALA327C, ALA327D, ARG255C, ARG255D, ARG310C, ARG310D, ARG317C, ARG317D, ASN320C, ASN320D, ASP250C, ASP250D, ASP280C, ASP280D, ASP328C, ASP328D, GLN283C, GLN283D, GLU248C, GLU248D, GLU319C, GLU319D, GLU329C, GLY279C, GLY279D, GLY311C, GLY311D, HIS276C, HIS276D, ILE252C, ILE252D, ILE275C, ILE275D, ILE278C, ILE278D, ILE326C, ILE326D, LEU253C, LEU253D, LEU254C, LEU254D, LEU312C, LEU312D, LEU318C, LEU318D, MET316C, MET316D, PHE249C, PHE249D, PRO247C, PRO247D, PRO251C, PRO251D, PRO256C, PRO256D, PRO322C, PRO322D, PRO323C, PRO323D, SER313C, SER313D, SER325C, SER325D, TRP321C, TRP321D, TYR277C, TYR277D, VAL282C, VAL282D
• C-E: ALA267C, ALA272C, ALA274C, ALA308E, ARG255E, ARG265C, ARG310E, ARG317E, ASN268C, ASN294C, ASP250E, CYS269C, GLU248E, GLU273C, GLY296C, GLY311E, GLY315E, ILE252E, LEU253E, LEU270C, LEU295C, LEU300C, LEU307E, LEU312E, LEU314E, LEU318E, MET316E, PHE249E, PRO251E, PRO293C, SER266C, SER299C, SER309E, SER313E, THR263C, THR301C, VAL264C
• C-F: ALA267C, ALA327F, ARG265C, ASN294C, ASP328F, CYS269C, GLU261C, GLU302C, GLU329F, ILE326F, LEU262C, LEU295C, SER266C, SER299C, SER325F, THR263C, VAL264C
• E-F: ALA274E, ALA274F, ALA324E, ALA324F, ALA327E, ALA327F, ARG255E, ARG255F, ARG310E, ARG310F, ARG317E, ARG317F, ASN320E, ASN320F, ASP250E, ASP250F, ASP280E, ASP280F, ASP328E, ASP328F, GLN283E, GLN283F, GLU248E, GLU248F, GLU319E, GLU319F, GLU329F, GLY279E, GLY279F, GLY311E, GLY311F, HIS276E, HIS276F, ILE252E, ILE252F, ILE275E, ILE275F, ILE278E, ILE278F, ILE326E, ILE326F, LEU253E, LEU253F, LEU254E, LEU254F, LEU312E, LEU312F, LEU318E, LEU318F, MET316E, MET316F, PHE249E, PHE249F, PRO247E, PRO247F, PRO251E, PRO251F, PRO256E, PRO256F, PRO322E, PRO322F, PRO323E, PRO323F, SER313E, SER313F, SER325E, SER325F, TRP321E, TRP321F, TYR277E, TYR277F, VAL282E, VAL282F
• E-G: ALA274E, ALA274G, ALA324G, ARG284E, ARG284G, ARG317E, ARG317G, ASN320E, ASN320G, ASP280E, ASP280G, GLN283E, GLN283G, GLU273E, GLU273G, GLU288E, GLU288G, GLU319E, GLU319G, GLY279E, GLY279G, GLY315E, GLY315G, ILE275E, ILE275G, LEU281G, LEU289G, LEU318E, LEU318G, MET316E, MET316G, PRO322E, PRO322G, PRO323E, PRO323G, THR285E, THR285G, TRP321E, TRP321G, VAL282E, VAL282G
• E-H: ALA324E, ALA324H, ALA327E, ALA327H, ARG284E, ARG284H, ASN320E, ASN320H, ASP328E, ASP328H, GLN283E, GLU288E, GLU319E, GLU319H, PHE249E, PRO247H, PRO322E, PRO322H, SER325H, TRP321E, TRP321H
• F-G: ALA274F, ALA274G, ALA324F, ALA324G, ALA327F, ALA327G, ARG284F, ARG284G, ASN320F, ASN320G, ASP328F, ASP328G, GLN283G, GLU273F, GLU273G, GLU288F, GLU288G, GLU319F, GLU319G, GLU329F, GLU329G, ILE275G, PHE249G, PRO322F, PRO322G, SER325F, THR292F, THR292G, TRP321F, TRP321G
• F-H: ALA274F, ALA274H, ARG284F, ARG284H, ARG317F, ARG317H, ASN320F, ASN320H, ASP280F, ASP280H, GLN283F, GLN283H, GLU273F, GLU273H, GLU288F, GLU288H, GLU319F, GLU319H, GLY315F, GLY315H, ILE275F, ILE275H, LEU289F, LEU289H, LEU318F, LEU318H, PRO322F, PRO322H, THR285F, THR285H, TRP321F, TRP321H, VAL287F, VAL287H
• G-H: ALA274G, ALA274H, ALA324G, ALA324H, ALA327G, ALA327H, ARG255G, ARG255H, ARG310G, ARG310H, ARG317G, ARG317H, ASN320G, ASN320H, ASP250G, ASP250H, ASP280G, ASP280H, ASP328G, ASP328H, GLN283G, GLN283H, GLU248G, GLU248H, GLU319G, GLU319H, GLU329G, GLY279G, GLY279H, GLY311G, GLY311H, HIS276G, HIS276H, ILE252G, ILE252H, ILE275G, ILE275H, ILE278G, ILE278H, ILE326G, ILE326H, LEU253G, LEU253H, LEU254G, LEU254H, LEU312G, LEU312H, LEU318G, LEU318H, MET316G, MET316H, PHE249G, PHE249H, PRO247G, PRO247H, PRO251G, PRO251H, PRO256G, PRO256H, PRO322G, PRO322H, PRO323G, PRO323H, SER313G, SER313H, SER325G, SER325H, TRP321G, TRP321H, TYR277G, TYR277H, VAL282G, VAL282H