3K39

crystal structure of b/perth neuraminidase d197e mutant in complex with peramivir

• Total interactions analyzed: 120
• Total true interactions: 35
• Strongest Interaction:
  • Chains: E-H
  • Int. Res.: 170
  • Norm. En. per Res.: -3.8029
• Hub Node: B(6)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-66.6379	-29.7494	-502.885	-599.2723	170	25	12	19791	4	43	43
A-C	0.0	12.7713	-0.6336	12.1377	12	0	0	69	0	2	1
A-D	-103.4995	-35.5537	-503.885	-642.9381	173	26	14	19686	4	45	44
B-C	-90.9577	-35.1131	-506.18	-632.2508	171	25	14	19784	4	44	44
B-D	0.0	12.3917	-0.5311	11.8606	11	0	0	62	0	2	1
B-E	0.0	0.3011	-45.2507	-44.9496	48	0	0	2470	0	15	17
B-F	-9.9914	0.0	-11.3048	-21.2962	32	5	0	737	0	5	2
B-I	-34.4439	-11.7584	-11.67	-57.8723	77	39	0	4573	0	29	49
B-J	0.0	0.0	-0.0325	-0.0325	3	0	0	16	0	2	1
C-D	-96.4105	-30.2328	-498.956	-625.5993	172	25	13	19783	4	43	44
C-F	0.0	0.0	-10.8934	-10.8934	29	0	0	746	0	3	2
C-I	0.0	0.0	-0.0238	-0.0238	3	0	0	11	0	2	1
C-M	0.0	0.0	-0.9961	-0.9961	5	0	0	122	0	4	3
E-F	-83.1032	-31.5803	-495.577	-610.2605	168	23	13	19596	4	43	43
E-G	0.0	12.3739	-0.5619	11.812	12	0	0	67	0	2	1
E-H	-108.469	-37.3397	-500.682	-646.4907	170	25	13	19518	5	43	44
E-J	0.0	0.0	-0.0022	-0.0022	4	0	0	6	0	1	3
E-N	0.0	0.0	-0.0068	-0.0068	3	0	0	5	0	1	2
F-G	-101.5343	-39.1147	-498.899	-639.548	174	23	14	19630	4	42	44
F-H	0.0	11.7704	-0.5481	11.2222	13	0	0	68	0	2	1
F-N	-3.5206	-7.1252	108.937	98.2913	82	37	0	4048	0	46	43
F-O	0.0	0.0	-0.004	-0.004	5	0	0	7	0	1	1
G-H	-92.9115	-32.0403	-496.568	-621.5197	169	16	12	19526	4	43	43
I-J	-89.5509	-34.6843	-496.345	-620.5802	173	24	14	19721	4	43	44
I-K	0.0	12.45	-0.5443	11.9057	11	0	0	60	0	2	1
I-L	-97.8092	-30.5749	-493.537	-621.9211	171	26	13	19736	4	43	44
J-K	-87.9865	-28.2124	-497.643	-613.8418	173	22	12	19685	4	43	43
J-L	0.0	12.3188	-0.5594	11.7593	12	0	0	65	0	2	1
K-L	-85.6565	-36.1977	-507.386	-629.2403	173	20	14	19724	4	44	44
M-N	-78.2237	-31.9857	-494.419	-604.6284	170	26	12	19678	4	43	43
M-O	0.0	12.4413	-0.5604	11.8809	12	0	0	65	0	2	1
M-P	-102.1136	-40.2255	-480.592	-622.9311	172	24	15	19497	4	42	44
N-O	-94.4568	-37.3934	-491.104	-622.9542	170	24	15	19569	4	43	44
N-P	0.0	11.7991	-0.5689	11.2302	14	0	0	68	0	2	1
O-P	-96.1956	-32.4969	-495.135	-623.8275	170	22	13	19626	4	43	44

Interface residues

• A-B: ALA111A, ALA111B, ALA136A, ALA137A, ALA175A, ALA176A, ALA200A, ALA209A, ALA442B, ALA444B, ALA465B, ALA95B, ARG102B, ARG150A, ARG154A, ARG260A, ASN109A, ASN109B, ASN144A, ASN151A, ASN169A, ASN169B, ASN198A, ASN199A, ASP184A, ASP194A, ASP212A, ASP417B, ASP421B, ASP457B, ASP463B, CYS122B, CYS127B, CYS420B, CYS424B, CYS447B, CYS87B, GLN138A, GLN138B, GLN453B, GLN93B, GLU105A, GLU105B, GLU126B, GLU168A, GLU168B, GLU187A, GLU197A, GLU208A, GLU258A, GLU405B, GLY104A, GLY104B, GLY108A, GLY108B, GLY123B, GLY140A, GLY141A, GLY145A, GLY162B, GLY192A, GLY195A, GLY207A, GLY259A, GLY450B, GLY452B, GLY461B, GLY89B, HIS101B, HIS134A, HIS155A, HIS173A, HIS215A, ILE114A, ILE120B, ILE157A, ILE164B, ILE171A, ILE204A, ILE261A, ILE415B, ILE445B, ILE98B, LEU113A, LEU153A, LEU156A, LEU161B, LEU201A, LEU202A, LEU448B, LEU454B, LEU455B, LEU466B, LEU96B, LEU97B, LYS107A, LYS107B, LYS125B, LYS128A, LYS152A, LYS160A, LYS160B, LYS163B, LYS186A, LYS203A, LYS205A, LYS416B, LYS418B, LYS419B, LYS94B, MET174A, MET449B, MET464B, PHE103A, PHE103B, PHE172A, PHE413B, PHE92B, PRO100B, PRO112A, PRO112B, PRO124B, PRO139A, PRO165B, PRO196A, PRO423B, PRO78A, PRO88B, SER110A, SER110B, SER158A, SER170A, SER170B, SER216A, SER402B, SER451B, SER86B, SER99B, THR106A, THR106B, THR133A, THR146A, THR166A, THR166B, THR211A, THR213A, THR443B, THR458B, THR460B, THR91B, TRP177A, TRP438B, TRP456B, TRP80A, TYR135A, TYR142A, TYR143A, TYR190A, TYR206A, TYR210A, TYR214A, TYR446B, VAL159A, VAL167A, VAL167B, VAL193A, VAL401B, VAL422B, VAL459B, VAL462B
• A-C: ALA111A, ALA111C, ASN109A, ASN109C, ASN169A, ASN169C, GLU168A, GLU168C, GLY108A, SER110A, SER110C, THR166C
• A-D: ALA111A, ALA111D, ALA136D, ALA137D, ALA175D, ALA176D, ALA200D, ALA209D, ALA442A, ALA444A, ALA465A, ALA95A, ARG102A, ARG150D, ARG154D, ARG260D, ARG84A, ASN109A, ASN109D, ASN144D, ASN151D, ASN169A, ASN169D, ASN198D, ASN199D, ASP184D, ASP194D, ASP212D, ASP417A, ASP421A, ASP457A, ASP463A, CYS122A, CYS127A, CYS420A, CYS424A, CYS447A, CYS87A, GLN138A, GLN138D, GLN453A, GLN93A, GLU105A, GLU105D, GLU126A, GLU168A, GLU168D, GLU187D, GLU197D, GLU208D, GLU258D, GLU405A, GLY104A, GLY104D, GLY108A, GLY108D, GLY123A, GLY140D, GLY141D, GLY145D, GLY162A, GLY192D, GLY195D, GLY207D, GLY259D, GLY450A, GLY452A, GLY461A, GLY89A, HIS101A, HIS134D, HIS155D, HIS173D, HIS215D, ILE114D, ILE120A, ILE157D, ILE164A, ILE171D, ILE204D, ILE261D, ILE415A, ILE445A, ILE98A, LEU113D, LEU153D, LEU156D, LEU161A, LEU201D, LEU202D, LEU448A, LEU454A, LEU455A, LEU466A, LEU96A, LEU97A, LYS107A, LYS107D, LYS125A, LYS128D, LYS152D, LYS160A, LYS160D, LYS163A, LYS186D, LYS203D, LYS205D, LYS416A, LYS418A, LYS419A, LYS94A, MET174D, MET449A, MET464A, PHE103A, PHE103D, PHE172D, PHE413A, PHE92A, PRO100A, PRO112A, PRO112D, PRO124A, PRO139D, PRO165A, PRO196D, PRO423A, PRO78D, PRO88A, SER110A, SER110D, SER158D, SER170A, SER170D, SER216D, SER402A, SER451A, SER86A, SER90A, SER99A, THR106A, THR106D, THR133D, THR146D, THR166A, THR166D, THR211D, THR213D, THR443A, THR458A, THR460A, THR91A, TRP177D, TRP438A, TRP456A, TRP80D, TYR135D, TYR142D, TYR143D, TYR190D, TYR206D, TYR210D, TYR214D, TYR446A, VAL159A, VAL159D, VAL167A, VAL167D, VAL193D, VAL401A, VAL422A, VAL459A, VAL462A
• B-C: ALA111B, ALA111C, ALA136B, ALA137B, ALA175B, ALA176B, ALA200B, ALA209B, ALA442C, ALA444C, ALA465C, ALA95C, ARG102C, ARG150B, ARG154B, ARG260B, ARG84C, ASN109B, ASN109C, ASN144B, ASN151B, ASN169B, ASN169C, ASN198B, ASN199B, ASP184B, ASP194B, ASP212B, ASP417C, ASP421C, ASP457C, ASP463C, CYS122C, CYS127C, CYS420C, CYS424C, CYS447C, CYS87C, GLN138B, GLN138C, GLN453C, GLN93C, GLU105B, GLU105C, GLU126C, GLU168B, GLU168C, GLU187B, GLU197B, GLU208B, GLU258B, GLU405C, GLY104B, GLY104C, GLY108B, GLY108C, GLY123C, GLY140B, GLY141B, GLY145B, GLY162C, GLY192B, GLY195B, GLY207B, GLY259B, GLY450C, GLY452C, GLY461C, GLY89C, HIS101C, HIS134B, HIS155B, HIS173B, HIS215B, HIS431C, ILE114B, ILE120C, ILE157B, ILE164C, ILE171B, ILE204B, ILE261B, ILE415C, ILE445C, ILE98C, LEU113B, LEU153B, LEU156B, LEU161C, LEU201B, LEU202B, LEU448C, LEU454C, LEU455C, LEU466C, LEU96C, LEU97C, LYS107B, LYS107C, LYS125C, LYS128B, LYS152B, LYS160C, LYS163C, LYS186B, LYS203B, LYS205B, LYS416C, LYS418C, LYS419C, LYS94C, MET174B, MET449C, MET464C, PHE103B, PHE103C, PHE172B, PHE413C, PHE92C, PRO100C, PRO112B, PRO112C, PRO124C, PRO139B, PRO165C, PRO196B, PRO423C, PRO78B, PRO88C, SER110B, SER110C, SER158B, SER170B, SER170C, SER216B, SER402C, SER451C, SER86C, SER90C, SER99C, THR106B, THR106C, THR133B, THR146B, THR166B, THR166C, THR211B, THR213B, THR443C, THR458C, THR460C, THR91C, TRP177B, TRP438C, TRP456C, TRP80B, TYR135B, TYR142B, TYR143B, TYR206B, TYR210B, TYR214B, TYR446C, VAL159B, VAL167B, VAL167C, VAL193B, VAL401C, VAL422C, VAL459C, VAL462C
• B-D: ALA111B, ALA111D, ASN109B, ASN109D, ASN169B, ASN169D, GLU168B, GLU168D, SER110B, THR166B, THR166D
• B-E: ALA218E, ALA312B, ALA312E, ARG252E, ARG270B, ARG315B, ASN198E, ASN199E, ASN219E, ASN340B, CYS251E, CYS337B, GLU250B, GLU250E, GLU264E, GLU313B, GLU338B, GLY243E, GLY269B, GLY269E, GLY335B, GLY341B, HIS215E, ILE248E, ILE262E, ILE265E, ILE314B, LEU316B, LYS263E, LYS272B, PHE266B, PHE266E, PRO267B, PRO267E, PRO336B, SER216E, SER339B, THR268B, THR268E, THR311B, THR311E, THR334B, THR389B, TRP388B, TYR214E, TYR217E, VAL271B, VAL271E
• B-F: ALA218B, ALA395F, ARG252B, ASN198B, ASN199B, ASN219B, ASN220B, ASP384F, ASP392F, GLN453F, GLU250B, GLU264B, GLY452F, HIS215B, ILE248B, ILE265B, LEU396F, LEU455F, LYS272B, LYS360F, MET357F, PHE266B, PRO267B, SER216B, SER359F, SER397F, SER451F, SER90F, THR268B, TYR217B, TYR383F, VAL271B
• B-I: ALA298B, ALA465B, ALA465I, ARG147B, ARG147I, ARG327B, ARG327I, ASN144B, ASN144I, ASN294B, ASN294I, ASP329B, ASP329I, ASP342B, ASP342I, ASP432B, ASP432I, ASP463B, ASP463I, GLU404B, GLU404I, GLU436B, GLU436I, GLY344B, GLY344I, GLY346B, GLY346I, GLY347B, GLY347I, GLY433B, GLY433I, GLY434B, GLY434I, HIS431B, HIS431I, HIS439B, HIS439I, LEU466B, LEU466I, LYS343B, LYS343I, LYS371B, LYS371I, LYS373B, LYS373I, LYS435B, LYS435I, MET369B, MET369I, MET375B, MET375I, MET403B, MET403I, MET464B, MET464I, PRO326B, PRO326I, PRO328B, PRO328I, SER345B, SER345I, SER370B, SER370I, THR106B, THR106I, THR325B, THR325I, THR372B, THR372I, THR437B, THR437I, TRP408B, TRP408I, TRP438B, TRP438I, TYR143B, TYR143I
• B-J: ASP329B, LYS107J, SER332B
• C-D: ALA111C, ALA111D, ALA136C, ALA137C, ALA175C, ALA176C, ALA200C, ALA209C, ALA442D, ALA444D, ALA465D, ALA95D, ARG102D, ARG150C, ARG154C, ARG260C, ARG84D, ASN109C, ASN109D, ASN144C, ASN151C, ASN169C, ASN169D, ASN198C, ASN199C, ASP184C, ASP194C, ASP212C, ASP417D, ASP421D, ASP457D, ASP463D, CYS122D, CYS127D, CYS420D, CYS424D, CYS447D, CYS87D, GLN138C, GLN138D, GLN453D, GLN93D, GLU105C, GLU105D, GLU126D, GLU168C, GLU168D, GLU187C, GLU197C, GLU208C, GLU258C, GLU405D, GLY104C, GLY104D, GLY108C, GLY108D, GLY123D, GLY140C, GLY141C, GLY145C, GLY162D, GLY192C, GLY195C, GLY207C, GLY259C, GLY450D, GLY452D, GLY461D, GLY89D, HIS101D, HIS134C, HIS155C, HIS173C, HIS215C, HIS431D, ILE114C, ILE120D, ILE157C, ILE164D, ILE171C, ILE204C, ILE261C, ILE415D, ILE445D, ILE98D, LEU113C, LEU153C, LEU156C, LEU161D, LEU201C, LEU202C, LEU448D, LEU454D, LEU455D, LEU466D, LEU96D, LEU97D, LYS107C, LYS107D, LYS125D, LYS128C, LYS152C, LYS160C, LYS160D, LYS163D, LYS186C, LYS203C, LYS205C, LYS416D, LYS418D, LYS419D, LYS94D, MET174C, MET449D, MET464D, PHE103C, PHE103D, PHE172C, PHE413D, PHE92D, PRO100D, PRO112C, PRO112D, PRO124D, PRO139C, PRO165D, PRO196C, PRO423D, PRO78C, PRO88D, SER110C, SER110D, SER158C, SER170C, SER170D, SER216C, SER402D, SER451D, SER86D, SER90D, SER99D, THR106C, THR106D, THR133C, THR146C, THR166C, THR166D, THR211C, THR213C, THR443D, THR458D, THR460D, THR91D, TRP177C, TRP438D, TRP456D, TRP80C, TYR135C, TYR142C, TYR143C, TYR206C, TYR210C, TYR214C, TYR446D, VAL159C, VAL167C, VAL167D, VAL193C, VAL401D, VAL422D, VAL459D, VAL462D
• C-F: ALA393F, ALA395C, ASP384C, ASP384F, ASP386F, ASP390F, ASP392C, ASP392F, GLN453C, GLU320F, GLY331F, GLY335F, GLY385F, GLY452C, ILE333F, LYS360C, LYS382C, LYS382F, PRO336F, SER332F, SER359C, SER391F, SER451C, SER90C, THR334F, THR389F, THR91C, TYR383C, TYR383F
• C-I: ASP329I, LYS107C, SER332I
• C-M: ALA358C, GLU436M, LEU85C, LYS435M, SER359C
• E-F: ALA111E, ALA111F, ALA136E, ALA137E, ALA175E, ALA176E, ALA200E, ALA209E, ALA442F, ALA444F, ALA465F, ALA95F, ARG102F, ARG150E, ARG154E, ARG260E, ARG84F, ASN109E, ASN109F, ASN144E, ASN151E, ASN169E, ASN169F, ASN198E, ASN199E, ASP184E, ASP194E, ASP212E, ASP417F, ASP421F, ASP457F, ASP463F, CYS122F, CYS127F, CYS420F, CYS424F, CYS447F, CYS87F, GLN138E, GLN138F, GLN453F, GLN93F, GLU105E, GLU105F, GLU126F, GLU168E, GLU168F, GLU187E, GLU197E, GLU208E, GLU258E, GLU405F, GLY104E, GLY104F, GLY108E, GLY108F, GLY123F, GLY140E, GLY141E, GLY145E, GLY162F, GLY192E, GLY195E, GLY207E, GLY259E, GLY450F, GLY452F, GLY461F, GLY89F, HIS101F, HIS134E, HIS155E, HIS173E, HIS215E, ILE114E, ILE120F, ILE157E, ILE164F, ILE171E, ILE204E, ILE261E, ILE415F, ILE445F, ILE98F, LEU113E, LEU153E, LEU156E, LEU161F, LEU201E, LEU202E, LEU448F, LEU454F, LEU455F, LEU466F, LEU96F, LEU97F, LYS107E, LYS107F, LYS125F, LYS152E, LYS160F, LYS163F, LYS186E, LYS203E, LYS205E, LYS416F, LYS418F, LYS419F, LYS94F, MET174E, MET449F, MET464F, PHE103E, PHE103F, PHE172E, PHE413F, PHE92F, PRO100F, PRO112E, PRO112F, PRO124F, PRO139E, PRO165F, PRO196E, PRO423F, PRO78E, PRO88F, SER110E, SER110F, SER158E, SER170E, SER170F, SER216E, SER402F, SER451F, SER86F, SER99F, THR106E, THR106F, THR133E, THR146E, THR166E, THR166F, THR211E, THR213E, THR443F, THR458F, THR460F, THR91F, TRP177E, TRP438F, TRP456F, TRP80E, TYR135E, TYR142E, TYR143E, TYR206E, TYR210E, TYR214E, TYR446F, VAL159E, VAL167E, VAL167F, VAL193E, VAL401F, VAL422F, VAL459F, VAL462F
• E-G: ALA111E, ALA111G, ASN109E, ASN109G, ASN169E, ASN169G, GLU168E, GLU168G, PRO139E, PRO139G, SER110E, SER110G
• E-H: ALA111E, ALA111H, ALA136H, ALA137H, ALA175H, ALA176H, ALA200H, ALA209H, ALA442E, ALA444E, ALA465E, ALA95E, ARG102E, ARG150H, ARG154H, ARG260H, ASN109E, ASN109H, ASN144H, ASN151H, ASN169E, ASN169H, ASN198H, ASN199H, ASP184H, ASP194H, ASP212H, ASP417E, ASP421E, ASP457E, ASP463E, CYS122E, CYS127E, CYS420E, CYS424E, CYS447E, CYS87E, GLN138E, GLN138H, GLN453E, GLN93E, GLU105E, GLU105H, GLU126E, GLU168E, GLU168H, GLU187H, GLU197H, GLU208H, GLU258H, GLU405E, GLY104E, GLY104H, GLY108E, GLY108H, GLY123E, GLY140H, GLY141H, GLY145H, GLY162E, GLY192H, GLY195H, GLY207H, GLY259H, GLY450E, GLY452E, GLY461E, GLY89E, HIS101E, HIS134H, HIS155H, HIS173H, HIS215H, ILE114H, ILE120E, ILE157H, ILE164E, ILE171H, ILE204H, ILE261H, ILE415E, ILE445E, ILE98E, LEU113H, LEU153H, LEU156H, LEU161E, LEU201H, LEU202H, LEU448E, LEU454E, LEU455E, LEU466E, LEU96E, LEU97E, LYS107E, LYS107H, LYS125E, LYS152H, LYS160E, LYS163E, LYS186H, LYS203H, LYS205H, LYS416E, LYS418E, LYS419E, LYS94E, MET174H, MET400E, MET449E, MET464E, PHE103E, PHE103H, PHE172H, PHE413E, PHE92E, PRO100E, PRO112E, PRO112H, PRO124E, PRO139H, PRO165E, PRO196H, PRO423E, PRO78H, PRO88E, SER110E, SER110H, SER158H, SER170E, SER170H, SER216H, SER402E, SER451E, SER86E, SER90E, SER99E, THR106E, THR106H, THR133H, THR146H, THR166E, THR166H, THR211H, THR213H, THR443E, THR458E, THR460E, THR91E, TRP177H, TRP438E, TRP456E, TRP80H, TYR135H, TYR142H, TYR143H, TYR206H, TYR210H, TYR214H, TYR446E, VAL159E, VAL159H, VAL167E, VAL167H, VAL193H, VAL401E, VAL422E, VAL459E, VAL462E
• E-J: ALA465J, GLU436J, LYS285E, THR309E
• E-N: ASN144E, ASP329N, LYS343N
• F-G: ALA111F, ALA111G, ALA136F, ALA137F, ALA175F, ALA176F, ALA200F, ALA209F, ALA442G, ALA444G, ALA465G, ALA95G, ARG102G, ARG150F, ARG154F, ARG260F, ARG84G, ASN109F, ASN109G, ASN144F, ASN151F, ASN169F, ASN169G, ASN198F, ASN199F, ASP184F, ASP194F, ASP212F, ASP417G, ASP421G, ASP457G, ASP463G, CYS122G, CYS127G, CYS420G, CYS424G, CYS447G, CYS87G, GLN138F, GLN138G, GLN453G, GLN93G, GLU105F, GLU105G, GLU126G, GLU168F, GLU168G, GLU187F, GLU197F, GLU208F, GLU258F, GLU405G, GLY104F, GLY104G, GLY108F, GLY108G, GLY123G, GLY140F, GLY141F, GLY145F, GLY162G, GLY192F, GLY195F, GLY207F, GLY259F, GLY450G, GLY452G, GLY461G, GLY89G, HIS101G, HIS134F, HIS155F, HIS173F, HIS215F, HIS431G, ILE114F, ILE120G, ILE157F, ILE164G, ILE171F, ILE204F, ILE261F, ILE415G, ILE445G, ILE98G, LEU113F, LEU153F, LEU156F, LEU161G, LEU201F, LEU202F, LEU448G, LEU454G, LEU455G, LEU466G, LEU96G, LEU97G, LYS107F, LYS107G, LYS125G, LYS128F, LYS152F, LYS160G, LYS163G, LYS186F, LYS203F, LYS205F, LYS416G, LYS418G, LYS419G, LYS94G, MET174F, MET400G, MET429G, MET449G, MET464G, PHE103F, PHE103G, PHE172F, PHE413G, PHE92G, PRO100G, PRO112F, PRO112G, PRO124G, PRO139F, PRO165G, PRO196F, PRO423G, PRO78F, PRO88G, SER110F, SER110G, SER158F, SER170F, SER170G, SER216F, SER402G, SER451G, SER86G, SER90G, SER99G, THR106F, THR106G, THR133F, THR146F, THR166F, THR166G, THR211F, THR213F, THR443G, THR458G, THR460G, THR91G, TRP177F, TRP438G, TRP456G, TRP80F, TYR135F, TYR142F, TYR143F, TYR206F, TYR210F, TYR214F, TYR446G, VAL159F, VAL159G, VAL167F, VAL167G, VAL193F, VAL401G, VAL422G, VAL459G, VAL462G
• F-H: ALA111F, ALA111H, ASN109F, ASN109H, ASN169F, ASN169H, GLU168F, GLU168H, GLY108H, SER110F, SER110H, THR166F, THR166H
• F-N: ALA245N, ALA465F, ALA465N, ARG116F, ARG147F, ARG147N, ARG150N, ARG292F, ARG327F, ARG374F, ASN294F, ASN294N, ASP149F, ASP149N, ASP329F, ASP342F, ASP342N, ASP432F, ASP432N, ASP463F, ASP463N, GLU197N, GLU404F, GLU405F, GLU436F, GLU436N, GLY145N, GLY148F, GLY148N, GLY344N, GLY346F, GLY346N, GLY347F, GLY433F, GLY433N, GLY434F, GLY434N, HIS431N, HIS439F, HIS439N, ILE221N, ILE348F, LEU466F, LEU466N, LYS107F, LYS107N, LYS343F, LYS343N, LYS371F, LYS373F, LYS373N, LYS435F, LYS435N, MET375F, MET375N, MET403F, MET464F, MET464N, PRO326F, PRO326N, PRO328F, PRO406F, PRO406N, SER246N, SER295N, SER345F, SER345N, SER370F, THR106N, THR325F, THR334F, THR372F, THR372N, THR437F, THR437N, TRP408F, TRP408N, TRP438N, TYR143N, TYR409F, VAL430F, VAL430N
• F-O: LEU466O, LYS107O, SER246F, SER345F, TYR296F
• G-H: ALA111G, ALA111H, ALA136G, ALA137G, ALA175G, ALA176G, ALA200G, ALA209G, ALA442H, ALA444H, ALA465H, ALA95H, ARG102H, ARG150G, ARG154G, ARG260G, ASN109G, ASN109H, ASN144G, ASN151G, ASN169G, ASN169H, ASN198G, ASN199G, ASP194G, ASP212G, ASP417H, ASP421H, ASP457H, ASP463H, CYS122H, CYS127H, CYS420H, CYS424H, CYS447H, CYS87H, GLN138G, GLN138H, GLN453H, GLN93H, GLU105G, GLU105H, GLU126H, GLU168G, GLU168H, GLU187G, GLU197G, GLU208G, GLU258G, GLU405H, GLY104G, GLY104H, GLY108G, GLY108H, GLY123H, GLY140G, GLY141G, GLY145G, GLY162H, GLY192G, GLY195G, GLY207G, GLY259G, GLY450H, GLY452H, GLY461H, GLY89H, HIS101H, HIS134G, HIS155G, HIS173G, HIS215G, HIS431H, ILE114G, ILE120H, ILE157G, ILE164H, ILE171G, ILE204G, ILE261G, ILE415H, ILE445H, ILE98H, LEU113G, LEU153G, LEU156G, LEU161H, LEU201G, LEU202G, LEU448H, LEU454H, LEU455H, LEU466H, LEU96H, LEU97H, LYS107G, LYS107H, LYS125H, LYS152G, LYS160G, LYS160H, LYS163H, LYS186G, LYS203G, LYS205G, LYS416H, LYS418H, LYS419H, LYS94H, MET174G, MET449H, MET464H, PHE103G, PHE103H, PHE172G, PHE413H, PHE92H, PRO100H, PRO112G, PRO112H, PRO124H, PRO139G, PRO165H, PRO196G, PRO423H, PRO78G, PRO88H, SER110G, SER110H, SER158G, SER170G, SER170H, SER216G, SER402H, SER451H, SER86H, SER90H, SER99H, THR106G, THR106H, THR133G, THR146G, THR166G, THR166H, THR211G, THR213G, THR443H, THR458H, THR460H, THR91H, TRP177G, TRP438H, TRP456H, TRP80G, TYR135G, TYR142G, TYR143G, TYR206G, TYR210G, TYR214G, TYR446H, VAL159G, VAL167G, VAL167H, VAL193G, VAL401H, VAL422H, VAL459H, VAL462H
• I-J: ALA111I, ALA111J, ALA136I, ALA137I, ALA175I, ALA176I, ALA200I, ALA209I, ALA442J, ALA444J, ALA465J, ALA95J, ARG102J, ARG150I, ARG154I, ARG260I, ARG84J, ASN109I, ASN109J, ASN144I, ASN151I, ASN169I, ASN169J, ASN198I, ASN199I, ASP184I, ASP194I, ASP212I, ASP417J, ASP421J, ASP457J, ASP463J, CYS122J, CYS127J, CYS420J, CYS424J, CYS447J, CYS87J, GLN138I, GLN138J, GLN453J, GLN93J, GLU105I, GLU105J, GLU126J, GLU168I, GLU168J, GLU187I, GLU197I, GLU208I, GLU258I, GLU405J, GLY104I, GLY104J, GLY108I, GLY108J, GLY123J, GLY140I, GLY141I, GLY145I, GLY162J, GLY192I, GLY195I, GLY207I, GLY259I, GLY450J, GLY452J, GLY461J, GLY89J, HIS101J, HIS134I, HIS155I, HIS173I, HIS215I, HIS431J, ILE114I, ILE120J, ILE157I, ILE164J, ILE171I, ILE204I, ILE261I, ILE415J, ILE445J, ILE98J, LEU113I, LEU153I, LEU156I, LEU161J, LEU201I, LEU202I, LEU448J, LEU454J, LEU455J, LEU466J, LEU96J, LEU97J, LYS107I, LYS107J, LYS125J, LYS128I, LYS152I, LYS160I, LYS160J, LYS163J, LYS186I, LYS203I, LYS205I, LYS416J, LYS418J, LYS419J, LYS94J, MET174I, MET400J, MET449J, MET464J, PHE103I, PHE103J, PHE172I, PHE413J, PHE92J, PRO100J, PRO112I, PRO112J, PRO124J, PRO139I, PRO165J, PRO196I, PRO423J, PRO78I, PRO88J, SER110I, SER110J, SER158I, SER170I, SER170J, SER216I, SER402J, SER451J, SER86J, SER90J, SER99J, THR106I, THR106J, THR133I, THR146I, THR166I, THR166J, THR211I, THR213I, THR443J, THR458J, THR460J, THR91J, TRP177I, TRP438J, TRP456J, TRP80I, TYR135I, TYR142I, TYR143I, TYR206I, TYR210I, TYR214I, TYR446J, VAL159I, VAL167I, VAL167J, VAL193I, VAL401J, VAL422J, VAL459J, VAL462J
• I-K: ALA111I, ALA111K, ASN109I, ASN109K, ASN169I, ASN169K, GLU168I, GLU168K, SER110I, THR166I, THR166K
• I-L: ALA111I, ALA111L, ALA136L, ALA137L, ALA175L, ALA176L, ALA200L, ALA209L, ALA442I, ALA444I, ALA465I, ALA95I, ARG102I, ARG150L, ARG154L, ARG260L, ARG84I, ASN109I, ASN109L, ASN144L, ASN151L, ASN169I, ASN169L, ASN198L, ASN199L, ASP184L, ASP194L, ASP212L, ASP417I, ASP421I, ASP457I, ASP463I, CYS122I, CYS127I, CYS420I, CYS424I, CYS447I, CYS87I, GLN138I, GLN138L, GLN453I, GLN93I, GLU105I, GLU105L, GLU126I, GLU168I, GLU168L, GLU187L, GLU197L, GLU208L, GLU258L, GLU405I, GLY104I, GLY104L, GLY108I, GLY108L, GLY123I, GLY140L, GLY141L, GLY145L, GLY162I, GLY192L, GLY195L, GLY207L, GLY259L, GLY450I, GLY452I, GLY461I, GLY89I, HIS101I, HIS134L, HIS155L, HIS173L, HIS215L, ILE114L, ILE120I, ILE157L, ILE164I, ILE171L, ILE204L, ILE261L, ILE415I, ILE445I, ILE98I, LEU113L, LEU153L, LEU156L, LEU161I, LEU201L, LEU202L, LEU448I, LEU454I, LEU455I, LEU466I, LEU96I, LEU97I, LYS107I, LYS107L, LYS125I, LYS128L, LYS152L, LYS160I, LYS163I, LYS186L, LYS203L, LYS205L, LYS416I, LYS418I, LYS419I, LYS94I, MET174L, MET449I, MET464I, PHE103I, PHE103L, PHE172L, PHE413I, PHE92I, PRO100I, PRO112I, PRO112L, PRO124I, PRO139L, PRO165I, PRO196L, PRO423I, PRO78L, PRO88I, SER110I, SER110L, SER158L, SER170I, SER170L, SER216L, SER402I, SER451I, SER86I, SER90I, SER99I, THR106I, THR106L, THR133L, THR146L, THR166I, THR166L, THR211L, THR213L, THR443I, THR458I, THR460I, THR91I, TRP177L, TRP438I, TRP456I, TRP80L, TYR135L, TYR142L, TYR143L, TYR206L, TYR210L, TYR214L, TYR446I, VAL159I, VAL159L, VAL167I, VAL167L, VAL193L, VAL401I, VAL422I, VAL459I, VAL462I
• J-K: ALA111J, ALA111K, ALA136J, ALA137J, ALA175J, ALA176J, ALA200J, ALA209J, ALA442K, ALA444K, ALA465K, ALA95K, ARG102K, ARG150J, ARG154J, ARG260J, ASN109J, ASN109K, ASN144J, ASN151J, ASN169J, ASN169K, ASN198J, ASN199J, ASP184J, ASP194J, ASP212J, ASP417K, ASP421K, ASP457K, ASP463K, CYS122K, CYS127K, CYS420K, CYS424K, CYS447K, CYS87K, GLN138J, GLN138K, GLN453K, GLN93K, GLU105J, GLU105K, GLU126K, GLU168J, GLU168K, GLU187J, GLU197J, GLU208J, GLU258J, GLU405K, GLY104J, GLY104K, GLY108J, GLY108K, GLY123K, GLY140J, GLY141J, GLY145J, GLY162K, GLY192J, GLY195J, GLY207J, GLY259J, GLY450K, GLY452K, GLY461K, GLY89K, HIS101K, HIS134J, HIS155J, HIS173J, HIS215J, HIS431K, ILE114J, ILE120K, ILE157J, ILE164K, ILE171J, ILE204J, ILE261J, ILE415K, ILE445K, ILE98K, LEU113J, LEU153J, LEU156J, LEU161K, LEU201J, LEU202J, LEU448K, LEU454K, LEU455K, LEU466K, LEU96K, LEU97K, LYS107J, LYS107K, LYS125K, LYS128J, LYS152J, LYS160J, LYS160K, LYS163J, LYS163K, LYS186J, LYS203J, LYS205J, LYS416K, LYS418K, LYS419K, LYS94K, MET174J, MET449K, MET464K, PHE103J, PHE103K, PHE172J, PHE413K, PHE92K, PRO100K, PRO112J, PRO112K, PRO124K, PRO139J, PRO165K, PRO196J, PRO423K, PRO78J, PRO88K, SER110J, SER110K, SER158J, SER170J, SER170K, SER216J, SER402K, SER451K, SER86K, SER90K, SER99K, THR106J, THR106K, THR133J, THR146J, THR166J, THR166K, THR211J, THR213J, THR443K, THR458K, THR460K, THR91K, TRP177J, TRP438K, TRP456K, TRP80J, TYR135J, TYR142J, TYR143J, TYR206J, TYR210J, TYR214J, TYR446K, VAL159J, VAL159K, VAL167J, VAL167K, VAL193J, VAL401K, VAL422K, VAL459K, VAL462K
• J-L: ALA111J, ALA111L, ASN109J, ASN109L, ASN169J, ASN169L, GLU168J, GLU168L, SER110J, SER110L, THR166J, THR166L
• K-L: ALA111K, ALA111L, ALA136K, ALA137K, ALA175K, ALA176K, ALA200K, ALA209K, ALA442L, ALA444L, ALA465L, ALA95L, ARG102L, ARG150K, ARG154K, ARG260K, ARG84L, ASN109K, ASN109L, ASN144K, ASN151K, ASN169K, ASN169L, ASN198K, ASN199K, ASP184K, ASP194K, ASP212K, ASP417L, ASP421L, ASP457L, ASP463L, CYS122L, CYS127L, CYS420L, CYS424L, CYS447L, CYS87L, GLN138K, GLN138L, GLN453L, GLN93L, GLU105K, GLU105L, GLU126L, GLU168K, GLU168L, GLU187K, GLU197K, GLU208K, GLU258K, GLU405L, GLY104K, GLY104L, GLY108K, GLY108L, GLY123L, GLY140K, GLY141K, GLY145K, GLY162L, GLY192K, GLY195K, GLY207K, GLY259K, GLY450L, GLY452L, GLY461L, GLY89L, HIS101L, HIS134K, HIS155K, HIS173K, HIS215K, ILE114K, ILE120L, ILE157K, ILE164L, ILE171K, ILE204K, ILE261K, ILE415L, ILE445L, ILE98L, LEU113K, LEU153K, LEU156K, LEU161L, LEU201K, LEU202K, LEU448L, LEU454L, LEU455L, LEU466L, LEU96L, LEU97L, LYS107K, LYS107L, LYS125L, LYS128K, LYS152K, LYS160L, LYS163L, LYS186K, LYS203K, LYS205K, LYS416L, LYS418L, LYS419L, LYS94L, MET174K, MET400L, MET449L, MET464L, PHE103K, PHE103L, PHE172K, PHE413L, PHE92L, PRO100L, PRO112K, PRO112L, PRO124L, PRO139K, PRO165L, PRO196K, PRO423L, PRO78K, PRO88L, SER110K, SER110L, SER158K, SER170K, SER170L, SER216K, SER402L, SER451L, SER86L, SER90L, SER99L, THR106K, THR106L, THR133K, THR146K, THR166K, THR166L, THR211K, THR213K, THR443L, THR458L, THR460L, THR91L, TRP177K, TRP438L, TRP456L, TRP80K, TYR135K, TYR142K, TYR143K, TYR190K, TYR206K, TYR210K, TYR214K, TYR446L, VAL159K, VAL159L, VAL167K, VAL167L, VAL193K, VAL401L, VAL422L, VAL459L, VAL462L
• M-N: ALA111M, ALA111N, ALA136M, ALA137M, ALA175M, ALA176M, ALA200M, ALA209M, ALA442N, ALA444N, ALA465N, ALA95N, ARG102N, ARG150M, ARG154M, ARG260M, ARG84N, ASN109M, ASN109N, ASN144M, ASN151M, ASN169M, ASN169N, ASN198M, ASN199M, ASP184M, ASP194M, ASP212M, ASP417N, ASP421N, ASP457N, ASP463N, CYS122N, CYS127N, CYS420N, CYS424N, CYS447N, CYS87N, GLN138M, GLN138N, GLN453N, GLN93N, GLU105M, GLU105N, GLU126N, GLU168M, GLU168N, GLU187M, GLU197M, GLU208M, GLU258M, GLU405N, GLY104M, GLY104N, GLY108M, GLY108N, GLY123N, GLY140M, GLY141M, GLY145M, GLY162N, GLY192M, GLY195M, GLY207M, GLY259M, GLY450N, GLY452N, GLY461N, GLY89N, HIS101N, HIS134M, HIS155M, HIS173M, HIS215M, ILE114M, ILE120N, ILE157M, ILE164N, ILE171M, ILE204M, ILE261M, ILE415N, ILE445N, ILE98N, LEU113M, LEU153M, LEU156M, LEU161N, LEU201M, LEU202M, LEU448N, LEU454N, LEU455N, LEU466N, LEU96N, LEU97N, LYS107M, LYS107N, LYS125N, LYS152M, LYS160M, LYS160N, LYS163N, LYS186M, LYS203M, LYS205M, LYS416N, LYS418N, LYS419N, LYS94N, MET174M, MET449N, MET464N, PHE103M, PHE103N, PHE172M, PHE413N, PHE92N, PRO100N, PRO112M, PRO112N, PRO124N, PRO139M, PRO165N, PRO196M, PRO423N, PRO78M, PRO88N, SER110M, SER110N, SER158M, SER170M, SER170N, SER216M, SER402N, SER451N, SER86N, SER99N, THR106M, THR106N, THR133M, THR146M, THR166M, THR166N, THR211M, THR213M, THR443N, THR458N, THR460N, THR91N, TRP177M, TRP438N, TRP456N, TRP80M, TYR135M, TYR142M, TYR143M, TYR190M, TYR206M, TYR210M, TYR214M, TYR446N, VAL159M, VAL167M, VAL167N, VAL193M, VAL401N, VAL422N, VAL459N, VAL462N
• M-O: ALA111M, ALA111O, ASN109M, ASN109O, ASN169M, ASN169O, GLU168M, GLU168O, PRO139M, PRO139O, SER110M, SER110O
• M-P: ALA111M, ALA111P, ALA136P, ALA137P, ALA175P, ALA176P, ALA200P, ALA209P, ALA442M, ALA444M, ALA465M, ALA95M, ARG102M, ARG150P, ARG154P, ARG260P, ARG84M, ASN109M, ASN109P, ASN144P, ASN151P, ASN169M, ASN169P, ASN198P, ASN199P, ASP184P, ASP194P, ASP212P, ASP417M, ASP421M, ASP457M, ASP463M, CYS122M, CYS127M, CYS420M, CYS424M, CYS447M, CYS87M, GLN138M, GLN138P, GLN453M, GLN93M, GLU105M, GLU105P, GLU126M, GLU168M, GLU168P, GLU187P, GLU197P, GLU208P, GLU258P, GLU405M, GLY104M, GLY104P, GLY108M, GLY108P, GLY123M, GLY140P, GLY141P, GLY145P, GLY162M, GLY192P, GLY195P, GLY207P, GLY259P, GLY450M, GLY452M, GLY461M, GLY89M, HIS101M, HIS134P, HIS155P, HIS173P, HIS215P, ILE114P, ILE120M, ILE157P, ILE164M, ILE171P, ILE204P, ILE261P, ILE415M, ILE445M, ILE98M, LEU113P, LEU153P, LEU156P, LEU161M, LEU201P, LEU202P, LEU448M, LEU454M, LEU455M, LEU466M, LEU96M, LEU97M, LYS107M, LYS107P, LYS125M, LYS152P, LYS160M, LYS160P, LYS163M, LYS186P, LYS203P, LYS205P, LYS416M, LYS418M, LYS419M, LYS94M, MET174P, MET400M, MET449M, MET464M, PHE103M, PHE103P, PHE172P, PHE413M, PHE92M, PRO100M, PRO112M, PRO112P, PRO124M, PRO139P, PRO165M, PRO196P, PRO423M, PRO78P, PRO88M, SER110M, SER110P, SER158P, SER170M, SER170P, SER216P, SER402M, SER451M, SER86M, SER90M, SER99M, THR106M, THR106P, THR133P, THR146P, THR166M, THR166P, THR211P, THR213P, THR443M, THR458M, THR460M, THR91M, TRP177P, TRP438M, TRP456M, TRP80P, TYR135P, TYR142P, TYR143P, TYR206P, TYR210P, TYR214P, TYR446M, VAL159M, VAL159P, VAL167M, VAL167P, VAL193P, VAL401M, VAL422M, VAL459M, VAL462M
• N-O: ALA111N, ALA111O, ALA136N, ALA137N, ALA175N, ALA176N, ALA200N, ALA209N, ALA442O, ALA444O, ALA465O, ALA95O, ARG102O, ARG150N, ARG154N, ARG260N, ASN109N, ASN109O, ASN144N, ASN151N, ASN169N, ASN169O, ASN198N, ASN199N, ASP194N, ASP212N, ASP417O, ASP421O, ASP457O, ASP463O, CYS122O, CYS127O, CYS420O, CYS424O, CYS447O, CYS87O, GLN138N, GLN138O, GLN453O, GLN93O, GLU105N, GLU105O, GLU126O, GLU168N, GLU168O, GLU187N, GLU197N, GLU208N, GLU258N, GLU405O, GLY104N, GLY104O, GLY108N, GLY108O, GLY123O, GLY140N, GLY141N, GLY145N, GLY162O, GLY192N, GLY195N, GLY207N, GLY259N, GLY450O, GLY452O, GLY461O, GLY89O, HIS101O, HIS134N, HIS155N, HIS173N, HIS215N, HIS431O, ILE114N, ILE120O, ILE157N, ILE164O, ILE171N, ILE204N, ILE261N, ILE415O, ILE445O, ILE98O, LEU113N, LEU153N, LEU156N, LEU161O, LEU201N, LEU202N, LEU448O, LEU454O, LEU455O, LEU466O, LEU96O, LEU97O, LYS107N, LYS107O, LYS125O, LYS152N, LYS160O, LYS163O, LYS186N, LYS203N, LYS205N, LYS416O, LYS418O, LYS419O, LYS94O, MET174N, MET400O, MET449O, MET464O, PHE103N, PHE103O, PHE172N, PHE413O, PHE92O, PRO100O, PRO112N, PRO112O, PRO124O, PRO139N, PRO165O, PRO196N, PRO423O, PRO78N, PRO88O, SER110N, SER110O, SER158N, SER170N, SER170O, SER216N, SER402O, SER451O, SER86O, SER90O, SER99O, THR106N, THR106O, THR133N, THR146N, THR166N, THR166O, THR211N, THR213N, THR443O, THR458O, THR460O, THR91O, TRP177N, TRP438O, TRP456O, TRP80N, TYR135N, TYR142N, TYR143N, TYR206N, TYR210N, TYR214N, TYR446O, VAL159N, VAL159O, VAL167N, VAL167O, VAL193N, VAL401O, VAL422O, VAL459O, VAL462O
• N-P: ALA111N, ALA111P, ASN109N, ASN109P, ASN169N, ASN169P, GLU168N, GLU168P, GLY108P, PRO139N, PRO139P, SER110N, SER110P, THR166P
• O-P: ALA111O, ALA111P, ALA136O, ALA137O, ALA175O, ALA176O, ALA200O, ALA209O, ALA442P, ALA444P, ALA465P, ALA95P, ARG102P, ARG150O, ARG154O, ARG260O, ARG84P, ASN109O, ASN109P, ASN144O, ASN151O, ASN169O, ASN169P, ASN198O, ASN199O, ASP194O, ASP212O, ASP417P, ASP421P, ASP457P, ASP463P, CYS122P, CYS127P, CYS420P, CYS424P, CYS447P, CYS87P, GLN138O, GLN138P, GLN453P, GLN93P, GLU105O, GLU105P, GLU126P, GLU168O, GLU168P, GLU187O, GLU197O, GLU208O, GLU258O, GLU405P, GLY104O, GLY104P, GLY108O, GLY108P, GLY123P, GLY140O, GLY141O, GLY145O, GLY162P, GLY192O, GLY195O, GLY207O, GLY259O, GLY450P, GLY452P, GLY461P, GLY89P, HIS101P, HIS134O, HIS155O, HIS173O, HIS215O, HIS431P, ILE114O, ILE120P, ILE157O, ILE164P, ILE171O, ILE204O, ILE261O, ILE415P, ILE445P, ILE98P, LEU113O, LEU153O, LEU156O, LEU161P, LEU201O, LEU202O, LEU448P, LEU454P, LEU455P, LEU466P, LEU96P, LEU97P, LYS107O, LYS107P, LYS125P, LYS152O, LYS160O, LYS160P, LYS163P, LYS186O, LYS203O, LYS205O, LYS416P, LYS418P, LYS419P, LYS94P, MET174O, MET449P, MET464P, PHE103O, PHE103P, PHE172O, PHE413P, PHE92P, PRO100P, PRO112O, PRO112P, PRO124P, PRO139O, PRO165P, PRO196O, PRO423P, PRO78O, PRO88P, SER110O, SER110P, SER158O, SER170O, SER170P, SER216O, SER402P, SER451P, SER86P, SER90P, SER99P, THR106O, THR106P, THR133O, THR146O, THR166O, THR166P, THR211O, THR213O, THR443P, THR458P, THR460P, THR91P, TRP177O, TRP438P, TRP456P, TRP80O, TYR135O, TYR142O, TYR143O, TYR206O, TYR210O, TYR214O, TYR446P, VAL159O, VAL167O, VAL167P, VAL193O, VAL401P, VAL422P, VAL459P, VAL462P