3K35

crystal structure of human sirt6

• Total interactions analyzed: 15
• Total true interactions: 10
• Strongest Interaction:
  • Chains: A-B
  • Int. Res.: 53
  • Norm. En. per Res.: -3.7753
• Hub Node: B(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-12.5488	-108.5787	-78.9638	-200.0913	53	1	0	3405	6	35	27
A-C	0.0	9.591	-9.6441	-0.0531	20	0	0	574	0	17	18
A-E	-7.4975	5.0537	-57.5003	-59.9441	37	3	0	2571	0	27	27
B-C	0.0	0.0	-0.001	-0.001	3	0	0	3	0	0	2
B-D	-44.7517	8.1238	-151.081	-187.7089	65	13	0	6112	0	15	14
B-E	0.0	0.0	-0.0431	-0.0431	2	0	0	20	0	4	0
B-F	0.0	0.0	-0.0256	-0.0256	3	0	0	15	0	4	3
C-D	-23.2752	-69.5347	-106.468	-199.2779	55	6	1	3827	5	35	37
C-E	-6.0895	-3.8779	-62.6003	-72.5677	40	1	0	2874	0	28	29
E-F	-22.2338	-14.3599	-40.6188	-77.2126	33	7	1	2146	1	25	27

Interface residues

• A-B: ALA196A, ALA196B, ALA198A, ALA201A, ALA201B, ALA205B, ALA226A, ALA226B, ARG106B, ARG193A, ARG193B, ARG203A, ARG203B, ARG218A, ARG218B, ARG229A, ARG229B, ARG230A, ARG230B, ASN204B, ASN222A, ASP125B, ASP192A, ASP192B, ASP194A, ASP194B, ASP199A, ASP199B, ASP206B, GLU187A, GLU200A, GLU200B, HIS244A, HIS247A, LEU130A, LEU190A, LEU195A, LEU195B, LEU197A, LEU197B, LEU223A, LEU225A, LYS243A, PHE107B, PRO191A, PRO191B, PRO219A, SER189A, SER202A, SER202B, SER220A, SER43B, SER44B
• A-C: ARG251A, ARG74C, ASP23A, GLU187C, GLU20A, GLU26A, GLU27A, GLU72C, GLU73C, GLY14C, GLY75C, ILE21A, LYS13C, LYS15C, PHE22A, PRO19A, PRO24A, PRO25A, TRP186C, TRP69C
• A-E: ALA248E, ALA77A, ARG246E, ARG251E, ARG74A, ASP23E, ASP245E, ASP249E, CYS16A, GLN240E, GLU27E, GLU72A, GLU73A, GLY14A, GLY75A, HIS244E, HIS247E, HIS253E, ILE21E, ILE236E, ILE252E, LEU18A, LEU250E, LEU76A, LYS13A, LYS15A, LYS15E, LYS243E, LYS31E, MET71A, PHE22E, PRO19E, PRO241E, PRO24E, THR242E, THR70A, TRP69A
• B-C: ALA174B, ARG203C, ARG230C
• B-D: ALA283B, ARG101B, ARG119B, ARG148B, ARG162B, ARG278B, ARG282B, ARG289D, ARG37D, ASP149B, ASP206D, ASP275B, CYS164B, GLN41D, GLN98D, GLU137B, GLU270D, GLU281B, GLU85B, GLY121B, GLY153B, GLY268D, GLY276B, LEU163B, LEU179B, LEU267D, LEU269D, LEU280B, LEU284B, LEU284D, LEU287D, LYS294D, MET134B, PHE122B, PHE135B, PRO123B, PRO277B, PRO285B, PRO285D, PRO286D, PRO288D, PRO290D, PRO291D, PRO293D, SER120B, SER42D, SER43D, THR144B, THR150B, THR154B, THR160B, THR165B, THR292D, TRP274B, TRP33D, TRP40D, TYR146B, VAL102D, VAL118B, VAL136B, VAL147B, VAL151B, VAL152B, VAL166B, VAL279B
• B-E: ARG180B, ARG218E
• B-F: ASP12F, GLY153B, THR154B
• C-D: ALA140C, ALA196C, ALA196D, ALA198C, ALA198D, ALA201C, ALA201D, ALA226D, ARG193C, ARG193D, ARG203C, ARG203D, ARG229D, ARG230C, ARG230D, ARG233D, ASN204C, ASN204D, ASP192C, ASP192D, ASP194C, ASP199C, ASP199D, CYS139C, CYS142C, CYS164C, CYS175C, GLU178C, GLU200C, GLU200D, GLY177C, GLY231D, GLY232D, LEU130C, LEU190C, LEU190D, LEU195C, LEU195D, LEU197C, LEU197D, LEU223C, LEU225D, LYS141C, LYS143C, LYS143D, LYS228D, PHE107C, PRO191C, PRO191D, PRO219C, SER189D, SER202D, THR144C, THR227D, VAL166C
• C-E: ALA248C, ALA77E, ARG246C, ARG251C, ARG63E, ARG74E, ASP23C, ASP245C, ASP249C, CYS16E, GLN216E, GLN240C, GLU27C, GLU72E, GLU73E, GLY14E, GLY75E, HIS244C, HIS247C, HIS253C, ILE21C, ILE236C, ILE252C, LEU18E, LEU250C, LEU76E, LYS13E, LYS15C, LYS15E, LYS243C, LYS31C, MET71E, PHE22C, PRO19C, PRO19E, PRO241C, PRO24C, THR242C, THR70E, TRP69E
• E-F: ALA140E, ALA159E, ALA196F, ALA198F, ALA201F, ARG106F, ARG176E, ARG180E, ARG193E, ARG193F, ARG203F, ARG230F, ASN204F, ASP125F, ASP192E, ASP192F, ASP194F, ASP199F, CYS139E, CYS142E, CYS175E, GLU178E, GLU200F, GLY177E, LEU190F, LEU195F, LEU197F, LYS141E, LYS143E, LYS158E, PHE107F, PRO191F, SER189F