3K1X

acidic fibroblast growth factor (fgf-1) complexed with dobesilate

• Total interactions analyzed: 15
• Total true interactions: 8
• Strongest Interaction:
  • Chains: A-C
  • Int. Res.: 51
  • Norm. En. per Res.: -3.2472
• Hub Node: A(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-21.1867	-25.6822	-112.412	-159.2809	56	9	1	4919	1	18	13
A-C	-33.3366	-28.9412	-103.33	-165.6079	51	4	0	3896	0	29	10
A-E	-2.6667	-0.1826	-116.659	-119.5083	64	12	3	5385	1	30	31
B-C	0.0	0.0	-46.4042	-46.4042	33	0	0	2171	0	1	2
B-E	0.0	0.0	-0.0176	-0.0176	2	0	0	11	0	1	1
D-E	0.0	-16.5992	-89.8977	-106.4969	49	8	1	3794	0	18	11
D-F	-8.9894	5.6463	-123.339	-126.6821	64	6	3	5493	1	23	19
E-F	0.0	-7.4215	-14.6629	-22.0844	12	0	0	752	0	8	10

Interface residues

• A-B: ALA58B, ARG16B, ARG27A, ARG29A, ARG29B, ASN84A, ASP20B, ASP28A, ASP28B, ASP31B, CYS8A, GLN32B, GLN35B, GLN55B, GLN69B, GLU52B, GLU83A, GLY11A, GLY12A, GLY21B, GLY54B, GLY67B, HIS13A, HIS33B, HIS85A, ILE17B, ILE34A, LEU123A, LEU125A, LEU127A, LEU18B, LEU5A, LEU6A, LYS120A, LYS4A, PHE14A, PRO126A, PRO128A, PRO19B, SER130A, SER30A, SER30B, SER50B, SER68B, SER9A, THR22B, THR26A, THR26B, THR53B, THR70B, TYR56B, TYR66B, TYR7A, TYR86A, VAL129A, VAL23B
• A-C: ALA58C, ARG111C, ARG114A, ARG16A, ARG27A, ARG29A, ASN106A, ASN10A, ASN72C, ASP20C, ASP24A, ASP28A, ASP31A, ASP60C, ASP62C, CYS109C, CYS8A, GLN119A, GLN55C, GLN69C, GLU74C, GLY107A, GLY11A, GLY12A, GLY21C, GLY25A, GLY67C, HIS13A, ILE17C, LEU18C, LEU64C, LEU65C, LYS104A, LYS105A, LYS110A, LYS93C, MET59C, PHE14A, PRO19C, SER108A, SER68C, SER9A, THR22C, THR26A, THR53C, THR61C, THR70C, TYR56C, TYR66C, TYR7A, VAL23C
• A-E: ALA95A, ALA95E, ARG80A, ARG80E, ASN84A, ASN84E, ASN87A, ASN98A, ASN98E, GLN119A, GLN119E, GLU45A, GLU45E, GLU73E, GLU79A, GLU79E, GLU82A, GLU82E, GLU83A, GLU83E, GLU96A, GLU96E, GLY118A, GLY118E, GLY44A, GLY44E, HIS116A, HIS116E, HIS85A, HIS85E, HIS94A, HIS94E, ILE122A, ILE122E, ILE90A, ILE90E, LEU123E, LEU76A, LEU76E, LEU78A, LEU78E, LEU81A, LEU81E, LYS120A, LYS92A, LYS92E, LYS93A, LYS93E, LYS97A, LYS97E, PHE100A, PHE100E, PHE77A, SER42A, SER42E, SER91A, THR88A, THR88E, TYR117A, TYR117E, TYR86A, TYR89A, VAL43A, VAL43E
• B-C: ASN72B, ASN72C, ASP20C, GLN37B, GLN55B, GLN55C, GLN69B, GLN69C, GLU41B, GLU52B, GLU52C, GLY54B, GLY54C, HIS33C, LYS1B, LYS49B, LYS49C, PRO19B, PRO19C, PRO71B, PRO71C, SER50B, SER50C, SER68C, THR51B, THR51C, THR53B, THR53C, THR70B, THR70C, TYR47B, TYR56B, TYR56C
• B-E: HIS116E, SER30B
• D-E: ARG16E, ARG27D, ARG29D, ASN10D, ASN84D, ASP20E, ASP28D, ASP28E, ASP31D, ASP31E, CYS8D, GLN32E, GLN55E, GLN69E, GLU52E, GLU83D, GLY12D, GLY21E, GLY54E, GLY67E, HIS13D, HIS33E, HIS85D, ILE17E, ILE34D, LEU125D, LEU127D, LEU18E, LEU5D, LEU64E, LEU6D, LYS120D, LYS4D, PHE14D, PRO126D, PRO128D, PRO19E, SER130D, SER30D, SER30E, SER50E, SER68E, SER9D, THR22E, THR26D, THR53E, TYR7D, TYR86D, VAL129D
• D-F: ALA40F, ALA95D, ARG29F, ARG80D, ASN84D, ASN84F, ASN87D, ASN87F, ASN98D, CYS8F, GLN37F, GLU45D, GLU79D, GLU79F, GLU82D, GLU82F, GLU83D, GLU83F, GLU96D, GLY118D, GLY12F, GLY44D, HIS85D, HIS85F, ILE122D, ILE90D, LEU125D, LEU125F, LEU127F, LEU36F, LEU38F, LEU5F, LEU6F, LEU78D, LEU81D, LEU81F, LYS1D, LYS1F, LYS2F, LYS4D, LYS4F, LYS92D, PHE100D, PHE124F, PHE14F, PRO126D, PRO126F, PRO128F, PRO3F, SER130F, SER39F, SER42D, SER91D, SER9F, THR88D, TRP99D, TYR117D, TYR7F, TYR86D, TYR86F, TYR89F, VAL129F, VAL43D, VAL46F
• E-F: ARG16E, ARG27E, ARG29E, ASN106E, ASP28E, ASP31E, LYS1F, LYS2F, PRO3F, SER130F, SER30E, THR26E