3K1Q

backbone model of an aquareovirus virion by cryo-electron microscopy and bioinformatics

• Total interactions analyzed: 300
• Total true interactions: 49
• Strongest Interaction:
  • Chains: F-K
  • Int. Res.: 2
  • Norm. En. per Res.: -3.0538
• Hub Node: A(6)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	0.0	-19.9819	-40.0236	-60.0055	77	9	0	3106	0	8	8
A-C	0.0	0.0	119.308	119.308	25	14	0	1753	0	2	2
A-D	0.0	12.2432	-43.9134	-31.6702	54	10	0	2894	0	5	5
A-I	0.0	0.0	121.021	121.021	29	32	1	2003	1	2	2
A-J	-10.2898	-6.3312	-21.4153	-38.0364	41	9	0	1850	1	6	4
A-K	0.0	2.4072	0.0	2.4072	2	0	0	0	0	1	0
B-C	-98.1027	-18.6031	1000.7	883.9942	182	257	10	14215	0	18	18
B-D	-19.7006	66.1626	2538.49	2584.9521	239	529	9	24121	0	33	50
C-D	-44.9602	-2.0766	107.94	60.9032	76	50	1	4790	0	18	10
C-E	-15.5613	-21.421	78.5446	41.5623	117	133	2	8361	0	9	12
D-I	0.0	0.0	-5.7505	-5.7505	25	11	0	738	0	2	0
D-P	-80.076	-10.1022			9
D-V	-74.1852	0.0			2
E-U	-37.1179	0.0			5
F-J	0.0	-2.7985	411.979	409.1805	38	56	0	2190	0	11	3
F-K	-6.1075	0.0	0.0	-6.1075	2	0	0	0	0	0	0
G-I	-4.7909	0.0	475.255	470.4641	74	75	3	5859	0	8	5
G-K	0.0	-2.8282	0.0	-2.8282	4	0	0	0	0	0	0
H-I	0.0	-2.9144	558.876	555.9615	42	75	0	2651	0	11	5
H-J	-5.5749	0.0	565.53	559.9551	76	79	3	6044	0	8	5
I-J	-307.6969	-197.3482	8222.64	7717.595	476	1435	31	59245	11	107	74
I-K	-352.122	-194.2448	1207.81	661.4432	217	311	13	16788	0	25	19
I-O	0.0	-5.1776			2
I-Q	-26.3112	30.3015			6
J-K	-280.7565	-191.2238	361.858	-110.1224	145	72	1	5224	0	13	12
J-Q	0.0	-5.4374			2
L-P	0.0	-2.2981			4
L-Q	-6.1733	0.0			2
M-O	-4.8476	0.0			2
M-Q	0.0	-2.8326			4
N-O	0.0	-2.9134			4
N-P	-5.625	0.0			2
O-P	-328.3319	-197.3707			73
O-Q	-355.8087	-195.1988			74
P-Q	-268.4834	-191.1797			69
P-U	0.0	-2.5237			2
P-W	-9.8846	40.0959			5
Q-W	0.0	-5.575			2
R-V	0.0	-2.803			4
R-W	-6.1853	0.0			2
S-U	-4.8074	0.0			2
S-W	0.0	-2.8259			4
T-U	0.0	-2.9138			4
T-V	-5.5859	0.0			2
U-V	-341.8713	-198.5995			73
U-W	-339.6337	-195.4881			74
U-X	0.0	-4.9181			2
V-W	-274.8658	-191.0372			69
X-Y	-25.0364	-3.2043			6

Interface residues

• A-B: ALA218A, ALA221A, ALA222A, ALA648B, ALA73A, ARG129A, ARG198A, ARG640B, ARG647B, ARG674B, ARG686B, ARG737B, ARG773B, ASN163A, ASN219A, ASN627B, ASN649B, ASN681B, ASN699B, ASN777B, ASP161A, ASP184A, ASP246A, ASP694B, GLN157A, GLN243A, GLN629B, GLN652B, GLN682B, GLN776B, GLU655B, GLY245A, GLY249A, HIS71A, ILE160A, ILE255A, ILE670B, LEU220A, LEU248A, LEU254A, LEU626B, LEU630B, LEU684B, LEU687B, LEU774B, LYS153A, MET675B, PHE625B, PHE74A, PHE771B, PRO155A, PRO185A, PRO199A, PRO628B, PRO633B, PRO653B, PRO671B, PRO683B, PRO685B, PRO770B, SER186A, SER251A, SER252A, SER253A, SER256A, SER672B, SER702B, THR200A, THR244A, THR703B, THR772B, TRP650B, TYR156A, TYR250A, VAL247A, VAL676B, VAL775B
• A-C: ALA150A, ALA600C, ARG137A, ASN163A, ASN632C, ASP136A, GLN595C, GLN608C, GLN634C, GLN635C, GLU597C, HIS607C, ILE148A, ILE151A, ILE599C, ILE601C, LEU630C, LYS153A, PHE154A, PRO596C, PRO598C, THR149A, THR152A, TYR156A, VAL164A
• A-D: ALA212A, ALA218A, ALA2D, ARG213A, ARG215A, ARG353A, ARG4D, ASN123D, ASN124D, ASN131D, ASN219A, ASP121D, ASP167A, ASP201D, ASP296A, GLN198D, GLN356A, GLN3D, GLN5D, GLU228A, GLY370A, HIS290A, LEU130D, LEU132D, LEU210A, LEU217A, MET135D, MET1D, PHE295A, PHE350A, PHE376A, PHE6D, PRO126D, PRO197D, PRO200D, PRO211A, PRO297A, PRO351A, SER122D, SER133D, SER199D, SER202D, SER214A, SER294A, SER298A, THR127D, THR293A, TYR125D, TYR128D, TYR352A, VAL129D, VAL292A, VAL293D, VAL354A
• A-I: ALA56I, ARG377A, ARG889A, ASN380A, ASN886A, ASP59I, GLN347A, GLN348A, GLY52I, GLY887A, ILE58I, LEU127I, LEU61I, PHE376A, PHE381A, PRO279I, PRO346A, PRO351A, PRO378A, PRO50I, SER54I, SER60I, THR278I, THR53I, THR57I, TRP349A, TYR359A, VAL379A, VAL51I
• A-J: ALA151J, ALA407A, ALA723A, ARG147J, ARG152J, ARG154J, ARG405A, ARG775A, ASN144J, ASN380A, ASN406A, ASP155J, ASP722A, ASP776A, CYS103J, GLN403A, GLN97J, GLY102J, GLY104J, ILE409A, ILE781A, LYS100J, MET143J, PHE381A, PHE867A, PHE96J, PRO105J, PRO382A, PRO869A, THR101J, THR10J, THR148J, THR408A, THR410A, THR782A, THR783A, THR99J, TYR404A, VAL140J, VAL724A, VAL777A
• A-K: ARG625K, ARG889A
• B-C: ALA1057C, ALA1110C, ALA1213B, ALA292C, ALA348B, ALA357B, ALA374B, ALA383B, ALA594C, ALA612C, ALA719C, ALA796C, ALA797C, ALA802C, ALA805C, ALA896C, ALA897C, ARG1016C, ARG1023C, ARG1211B, ARG328B, ARG370B, ARG373B, ARG686B, ARG787C, ARG793C, ARG801C, ARG889C, ASN1025C, ASN1108C, ASN289C, ASN375B, ASN421B, ASN425B, ASN426B, ASN429B, ASN591C, ASN830B, ASP1050C, ASP1155B, ASP320B, ASP548C, ASP552C, ASP795C, ASP799C, ASP892C, ASP928C, GLN1030C, GLN1053C, GLN353B, GLN358B, GLN555C, GLN595C, GLN608C, GLN614C, GLN890C, GLU380B, GLU547C, GLY1018C, GLY1111C, GLY327B, GLY378B, GLY379B, GLY605C, GLY619C, GLY794C, GLY838B, GLY927C, HIS559C, HIS607C, HIS617C, HIS804C, HIS835B, HIS836B, ILE1020C, ILE1032C, ILE1041C, ILE1154B, ILE220B, ILE324B, ILE377B, ILE432B, ILE434B, ILE800C, ILE832B, LEU1027C, LEU1031C, LEU1052C, LEU219B, LEU278C, LEU291C, LEU350B, LEU376B, LEU427B, LEU428B, LEU436B, LEU687B, LEU831B, LYS584C, LYS839B, MET1208B, MET228B, MET329B, MET606C, PHE1017C, PHE1059C, PHE222B, PHE225B, PHE317B, PHE550C, PHE615C, PHE807C, PHE891C, PRO1022C, PRO1024C, PRO1109C, PRO1126B, PRO290C, PRO351B, PRO433B, PRO551C, PRO596C, PRO611C, PRO618C, PRO685B, PRO833B, SER1049C, SER1055C, SER1212B, SER319B, SER361B, SER382B, SER430B, SER435B, SER463C, SER553C, SER554C, SER556C, SER613C, SER616C, SER834B, SER895C, THR1019C, THR1214B, THR318B, THR322B, THR323B, THR325B, THR352B, THR354B, THR431B, THR558C, THR609C, THR610C, THR688B, THR720C, THR803C, THR806C, THR829B, THR894C, TYR1062C, TYR1209B, TYR229B, TYR282C, TYR837B, TYR926C, VAL1021C, VAL1051C, VAL1054C, VAL1056C, VAL1058C, VAL1210B, VAL321B, VAL349B, VAL381B, VAL417B, VAL620C, VAL689B, VAL721C, VAL785C, VAL798C, VAL893C
• B-D: ALA101D, ALA105D, ALA168D, ALA169D, ALA172D, ALA173D, ALA176D, ALA183D, ALA186D, ALA189D, ALA193D, ALA237D, ALA240D, ALA30D, ALA34D, ALA363D, ALA374B, ALA383B, ALA393B, ALA446B, ALA45D, ALA56D, ALA791B, ALA877B, ALA932B, ALA960B, ARG1178B, ARG191D, ARG225D, ARG35D, ARG367B, ARG407B, ARG40D, ARG437B, ARG64D, ARG793B, ARG861B, ARG868B, ARG883B, ARG93D, ARG947B, ARG959B, ASN1176B, ASN1182B, ASN1192B, ASN242D, ASN24D, ASN251D, ASN375B, ASN673B, ASP1183B, ASP201D, ASP252D, ASP25D, ASP372B, ASP412B, ASP450B, ASP795B, ASP933B, ASP94D, CYS32D, GLN107D, GLN187D, GLN195D, GLN245D, GLN27D, GLN411B, GLN415B, GLN418B, GLN663B, GLN792B, GLN962B, GLN963B, GLU235D, GLU28D, GLU367D, GLU380B, GLU386B, GLU400B, GLU422B, GLU449B, GLU862B, GLU948B, GLY1180B, GLY179D, GLY194D, GLY31D, GLY378B, GLY49D, GLY664B, GLY794B, GLY878B, GLY953B, HIS184D, HIS397B, HIS410B, HIS43D, HIS949B, HIS956B, HIS958B, ILE106D, ILE182D, ILE366D, ILE377B, ILE398B, ILE403B, ILE416B, ILE419B, ILE432B, ILE434B, ILE440B, ILE46D, ILE90D, ILE957B, LEU100D, LEU1184B, LEU174D, LEU185D, LEU196D, LEU241D, LEU248D, LEU26D, LEU29D, LEU370D, LEU371B, LEU376B, LEU394B, LEU396B, LEU405B, LEU406B, LEU436B, LEU441B, LEU44D, LEU51D, LEU662B, LEU71D, LEU880B, LEU934B, LEU97D, LYS238D, LYS249D, MET175D, MET204D, MET384B, MET404B, MET409B, PHE1199B, PHE192D, PHE232D, PHE41D, PHE445B, PHE864B, PHE879B, PRO102D, PRO104D, PRO108D, PRO1175B, PRO1185B, PRO181D, PRO197D, PRO200D, PRO239D, PRO243D, PRO36D, PRO413B, PRO433B, PRO438B, PRO52D, PRO59D, PRO671B, PRO790B, PRO882B, PRO884B, PRO951B, PRO952B, PRO954B, PRO95D, SER1193B, SER133D, SER199D, SER39D, SER408B, SER42D, SER435B, SER447B, SER448B, SER47D, SER50D, SER55D, SER660B, SER665B, SER672B, SER869B, SER935B, SER955B, SER98D, SER99D, THR1181B, THR1189B, THR170D, THR171D, THR178D, THR188D, THR203D, THR207D, THR38D, THR401B, THR414B, THR439B, THR48D, THR661B, TRP250D, TRP37D, TRP444B, TRP54D, TRP92D, TYR1177B, TYR1195B, TYR1197B, TYR177D, TYR190D, TYR233D, TYR33D, TYR359D, TYR362D, TYR402B, TYR58D, VAL103D, VAL1179B, VAL180D, VAL247D, VAL417B, VAL53D, VAL858B, VAL865B, VAL881B, VAL946B, VAL950B, VAL96D
• C-D: ALA168D, ALA169D, ALA172D, ALA254D, ALA256D, ALA786C, ALA791C, ALA796C, ALA797C, ALA802C, ALA937C, ARG225D, ARG227D, ARG255D, ARG342D, ARG793C, ARG801C, ARG947C, ASN224D, ASN230D, ASN251D, ASN782C, ASN944C, ASP201D, ASP252D, ASP344D, ASP789C, ASP795C, ASP799C, GLN776C, GLN792C, GLN940C, GLU235D, GLY231D, GLY253D, GLY345D, GLY605C, GLY619C, GLY794C, GLY942C, GLY943C, HIS617C, ILE347D, LEU248D, LEU346D, LEU784C, LEU939C, LYS249D, MET166D, MET175D, PHE234D, PRO167D, PRO258D, PRO604C, PRO618C, PRO790C, SER202D, SER226D, SER616C, THR171D, THR178D, THR203D, THR228D, THR348D, TRP250D, TRP341D, TRP621C, TYR233D, TYR938C, TYR941C, VAL247D, VAL603C, VAL620C, VAL785C, VAL945C, VAL946C
• C-E: ALA168E, ALA169E, ALA172E, ALA173E, ALA176E, ALA183E, ALA186E, ALA189E, ALA193E, ALA237E, ALA374C, ALA383C, ARG1178C, ARG141C, ARG191E, ARG255E, ARG373C, ARG407C, ARG40E, ARG437C, ARG959C, ASN1182C, ASN251E, ASN375C, ASP252E, ASP372C, ASP412C, GLN140E, GLN187E, GLN195E, GLN198E, GLN245E, GLN411C, GLN415C, GLN418C, GLU386C, GLU400C, GLY1180C, GLY179E, GLY194E, GLY253E, GLY378C, GLY379C, GLY49E, GLY953C, HIS184E, HIS397C, HIS410C, HIS43E, HIS956C, ILE208E, ILE377C, ILE403C, ILE432C, ILE434C, ILE440C, ILE46E, LEU174E, LEU185E, LEU196E, LEU248E, LEU376C, LEU405C, LEU406C, LEU436C, LEU441C, LEU44E, LYS238E, LYS249E, MET175E, MET204E, MET384C, MET404C, MET409C, PHE1199C, PHE192E, PHE232E, PHE445C, PRO167E, PRO181E, PRO197E, PRO433C, PRO438C, PRO954C, SER1193C, SER199E, SER202E, SER289E, SER39E, SER408C, SER42E, SER435C, SER47E, SER50E, SER955C, THR1181C, THR170E, THR171E, THR178E, THR188E, THR203E, THR207E, THR401C, THR414C, THR431C, THR439C, THR48E, THR661C, TRP136E, TRP250E, TYR1195C, TYR1197C, TYR177E, TYR190E, VAL1179C, VAL180E, VAL247E
• D-I: ALA56I, ALA80D, ARG49I, ASN124D, ASN133I, GLN70I, GLN83D, GLU116D, GLY52I, GLY81D, GLY82D, ILE84D, PHE68I, PRO50I, SER116I, SER54I, THR114I, THR132I, THR53I, THR57I, THR85D, TYR125D, VAL111D, VAL114D, VAL55I
• D-P: ARG49P, ASN390D, ASP393D, PHE389D, PRO50P, SER54P, THR53P, TYR14D, VAL55P
• D-V: GLN343D, SER54V
• E-U: ARG49U, ASP327E, GLN408E, PRO332E, SER54U
• F-J: ALA236F, ALA491J, ALA60F, ASN492J, ASN61F, ASP303J, CYS237F, GLN383J, GLN384J, GLN493J, GLN551J, GLN585J, GLN8F, GLU302J, GLU496J, GLU497J, GLY587J, HIS11F, HIS4F, ILE588J, ILE6F, LEU3F, LEU549J, LYS300J, MET1F, MET5F, PRO2F, PRO589J, SER495J, SER500J, THR494J, THR592J, TYR238F, TYR46F, VAL498J, VAL586J, VAL590J, VAL9F
• F-K: ALA400K, GLY44F
• G-I: ALA12G, ALA16G, ALA19G, ALA325I, ALA399I, ALA400I, ALA402I, ALA404I, ALA424I, ARG131G, ARG15G, ARG188G, ARG21G, ARG45G, ASN363I, ASN406I, ASP136G, ASP365I, CYS189G, CYS43G, GLN423I, GLU127G, GLU31G, GLY193G, GLY324I, GLY401I, GLY44G, HIS171G, HIS421I, ILE405I, ILE445I, LEU128G, LEU135G, LEU194G, LEU195G, LEU196G, LEU320I, LEU366I, LEU420I, LEU422I, LYS191G, LYS318I, MET1G, PHE130G, PHE373I, PRO129G, PRO168G, PRO190G, PRO364I, PRO446I, PRO448I, SER139G, SER323I, SER367I, SER369I, SER398I, SER403I, SER447I, THR132G, THR192G, THR23G, THR30G, THR321I, THR326I, THR362I, THR368I, THR425I, THR42G, THR449I, TYR322I, TYR46G, VAL396I, VAL397I, VAL9G
• G-K: GLU302K, GLU497K, HIS11G, HIS4G
• H-I: ALA236H, ALA491I, ALA60H, ASN492I, ASN61H, ASP303I, CYS237H, GLN383I, GLN384I, GLN493I, GLN551I, GLN554I, GLN585I, GLN8H, GLU302I, GLU496I, GLU497I, GLY587I, HIS11H, HIS4H, HIS59H, ILE588I, ILE6H, LEU3H, LEU549I, LEU584I, LYS300I, MET1H, MET490I, MET5H, PRO2H, PRO589I, SER495I, SER500I, THR494I, THR592I, TYR238H, TYR46H, VAL498I, VAL586I, VAL590I, VAL9H
• H-J: ALA12H, ALA16H, ALA19H, ALA325J, ALA399J, ALA400J, ALA402J, ALA404J, ALA424J, ARG131H, ARG15H, ARG188H, ARG21H, ARG45H, ASN363J, ASN406J, ASP136H, ASP365J, CYS189H, CYS43H, GLN423J, GLU127H, GLU31H, GLY193H, GLY324J, GLY401J, GLY44H, HIS171H, HIS421J, ILE405J, ILE445J, LEU128H, LEU135H, LEU194H, LEU195H, LEU196H, LEU22H, LEU320J, LEU366J, LEU420J, LEU422J, LYS191H, LYS318J, MET1H, PHE130H, PHE373J, PRO129H, PRO168H, PRO190H, PRO364J, PRO446J, PRO448J, SER139H, SER323J, SER367J, SER369J, SER398J, SER403J, SER447J, THR132H, THR192H, THR23H, THR30H, THR321J, THR326J, THR362J, THR368J, THR425J, THR42H, THR449J, TYR322J, TYR46H, VAL370J, VAL396J, VAL397J, VAL9H
• I-J: ALA121I, ALA123I, ALA126I, ALA150I, ALA151I, ALA157I, ALA166I, ALA176I, ALA188I, ALA190I, ALA211I, ALA217I, ALA230J, ALA232J, ALA239I, ALA239J, ALA241J, ALA244J, ALA245I, ALA245J, ALA267J, ALA276J, ALA290J, ALA297I, ALA304I, ALA30I, ALA30J, ALA31I, ALA31J, ALA33I, ALA33J, ALA408J, ALA483J, ALA487J, ALA499I, ALA503J, ALA518I, ALA524I, ALA528I, ALA535J, ALA538J, ALA544J, ALA555J, ALA572I, ALA573I, ALA599J, ALA607J, ALA620I, ALA620J, ALA626I, ALA633I, ALA636I, ALA85I, ALA85J, ARG147I, ARG152I, ARG154I, ARG214I, ARG292I, ARG295I, ARG337I, ARG412J, ARG416I, ARG416J, ARG428J, ARG472J, ARG530I, ARG542J, ARG571I, ARG609I, ARG609J, ARG625I, ARG627I, ARG67I, ARG79I, ARG79J, ASN129I, ASN198I, ASN243I, ASN243J, ASN312I, ASN406J, ASN410J, ASN418J, ASN42I, ASN456I, ASN504J, ASN515I, ASN519I, ASN579I, ASN75I, ASN90J, ASP125I, ASP128I, ASP155I, ASP164I, ASP173I, ASP192I, ASP197I, ASP25J, ASP270J, ASP272J, ASP277J, ASP303I, ASP346J, ASP352J, ASP35I, ASP35J, ASP361I, ASP461I, ASP482J, ASP523I, ASP532I, ASP532J, ASP533J, ASP561J, ASP619I, ASP639I, ASP66I, ASP88I, ASP88J, CYS200I, GLN146I, GLN160I, GLN231J, GLN261I, GLN261J, GLN330I, GLN414J, GLN423J, GLN546J, GLN551J, GLN585I, GLN593J, GLN628I, GLN640I, GLN70I, GLN93J, GLU237J, GLU248J, GLU275J, GLU302I, GLU309I, GLU427J, GLU429J, GLU473J, GLU496I, GLU497I, GLU622I, GLU76I, GLU76J, GLU80J, GLY120I, GLY124I, GLY236J, GLY240I, GLY240J, GLY250I, GLY250J, GLY254I, GLY254J, GLY268J, GLY332I, GLY334I, GLY355J, GLY39I, GLY39J, GLY413J, GLY441I, GLY45I, GLY462I, GLY522I, GLY595J, GLY603J, GLY605J, GLY611J, GLY614I, GLY614J, GLY616I, GLY616J, GLY642I, GLY69I, GLY77I, GLY77J, HIS162I, HIS213J, HIS233J, HIS421J, HIS513J, HIS547J, ILE106J, ILE137I, ILE142I, ILE149I, ILE174I, ILE193I, ILE263I, ILE263J, ILE274J, ILE299I, ILE307I, ILE34I, ILE34J, ILE357I, ILE357J, ILE405J, ILE409J, ILE484J, ILE525I, ILE525J, ILE539J, ILE588I, ILE63I, ILE641I, ILE89I, ILE89J, LEU108J, LEU127I, LEU145I, LEU158I, LEU163I, LEU170I, LEU186I, LEU194I, LEU196I, LEU201I, LEU227J, LEU235J, LEU252I, LEU252J, LEU259I, LEU259J, LEU271J, LEU273J, LEU280J, LEU289J, LEU315I, LEU331I, LEU358I, LEU358J, LEU36I, LEU36J, LEU407J, LEU41I, LEU420J, LEU440I, LEU459I, LEU470J, LEU471J, LEU47I, LEU543J, LEU549J, LEU564J, LEU565J, LEU582I, LEU597J, LEU600J, LEU608J, LEU613J, LEU624I, LEU630I, LEU644I, LEU86J, LYS161I, LYS191I, LYS269J, LYS300I, LYS37I, LYS37J, LYS46I, LYS516J, LYS548J, LYS570I, LYS570J, LYS615I, LYS615J, LYS623I, LYS634I, LYS84J, MET143I, MET153I, MET167I, MET169I, MET266J, MET26I, MET26J, MET419J, MET460I, MET575I, MET596J, MET78I, MET91I, MET91J, PHE189I, PHE242J, PHE285J, PHE298I, PHE310I, PHE417J, PHE443I, PHE454I, PHE576I, PHE637I, PHE638I, PHE68I, PHE73I, PHE82I, PHE82J, PHE87J, PRO105J, PRO172I, PRO195I, PRO216I, PRO216J, PRO234J, PRO279J, PRO281J, PRO287J, PRO291J, PRO296I, PRO301I, PRO32I, PRO32J, PRO333I, PRO335I, PRO359I, PRO371J, PRO38I, PRO38J, PRO415J, PRO43I, PRO457I, PRO468J, PRO486J, PRO526I, PRO526J, PRO559J, PRO560J, PRO563J, PRO580I, PRO646I, PRO94J, SER109J, SER110J, SER138I, SER175I, SER247J, SER24I, SER251I, SER251J, SER255I, SER255J, SER256I, SER256J, SER257I, SER257J, SER260I, SER260J, SER264I, SER264J, SER283J, SER288J, SER28I, SER28J, SER313I, SER354J, SER455I, SER495I, SER500I, SER529I, SER534J, SER537J, SER541J, SER550J, SER574I, SER578I, SER581I, SER594J, SER598J, SER602J, SER612J, SER621I, SER629I, SER643I, SER65I, SER72I, SER83J, THR122I, THR139I, THR148I, THR165I, THR168I, THR171I, THR23I, THR246J, THR258I, THR258J, THR265J, THR278J, THR27I, THR286J, THR29I, THR29J, THR328I, THR336I, THR350J, THR356I, THR356J, THR425J, THR442I, THR44I, THR458I, THR465J, THR467J, THR474J, THR475J, THR488J, THR494I, THR531I, THR531J, THR536J, THR558J, THR601J, THR606J, THR610I, THR610J, THR618I, THR631I, THR81I, THR81J, TRP159I, TRP48I, TRP566J, TRP645I, TRP92I, TRP92J, TYR215I, TYR294I, TYR327I, TYR360I, TYR562J, TYR71I, VAL107J, VAL119I, VAL140I, VAL156I, VAL210I, VAL238J, VAL249I, VAL249J, VAL253I, VAL253J, VAL282J, VAL284J, VAL329I, VAL348J, VAL353J, VAL40I, VAL40J, VAL411J, VAL469J, VAL480J, VAL481J, VAL485J, VAL520I, VAL521I, VAL527I, VAL540J, VAL545J, VAL577I, VAL604J, VAL617I, VAL617J, VAL632I, VAL64I, VAL74I
• I-K: ALA121K, ALA123K, ALA126K, ALA150K, ALA151K, ALA230I, ALA232I, ALA239I, ALA241I, ALA244I, ALA245I, ALA30I, ALA30K, ALA31I, ALA31K, ALA33I, ALA33K, ALA528K, ALA538I, ALA607I, ALA85I, ALA85K, ARG147K, ARG152K, ARG154K, ARG214K, ARG295K, ARG412I, ARG416I, ARG472I, ARG530K, ARG542I, ARG571K, ARG609I, ARG625K, ARG627K, ARG67K, ARG79I, ARG79K, ASN129K, ASN243I, ASN418I, ASN42K, ASN456K, ASN75K, ASN90I, ASP125K, ASP128K, ASP155K, ASP164K, ASP173K, ASP192K, ASP25I, ASP270I, ASP272I, ASP277I, ASP346I, ASP35I, ASP35K, ASP361K, ASP461K, ASP482I, ASP532I, ASP533I, ASP561I, ASP619K, ASP66K, ASP88I, ASP88K, GLN146K, GLN160K, GLN231I, GLN640K, GLN70K, GLN93I, GLU237I, GLU248I, GLU275I, GLU473I, GLU496K, GLU622K, GLU76I, GLU76K, GLU80I, GLY120K, GLY124K, GLY236I, GLY240I, GLY254I, GLY39K, GLY45K, GLY603I, GLY605I, GLY611I, GLY614I, GLY69K, GLY77I, GLY77K, HIS162K, HIS213I, HIS233I, HIS421I, ILE106I, ILE137K, ILE142K, ILE149K, ILE263I, ILE34I, ILE34K, ILE63K, ILE89I, ILE89K, LEU108I, LEU127K, LEU145K, LEU227I, LEU235I, LEU252I, LEU259I, LEU271I, LEU36I, LEU36K, LEU41K, LEU47K, LEU608I, LEU613I, LEU86I, LYS161K, LYS300K, LYS37I, LYS37K, LYS46K, LYS570K, LYS615K, LYS623K, LYS634K, LYS84I, MET143K, MET153K, MET26I, MET26K, MET419I, MET78K, MET91I, MET91K, PHE242I, PHE298K, PHE68K, PHE73K, PHE82I, PHE82K, PHE87I, PRO105I, PRO216I, PRO234I, PRO32I, PRO32K, PRO38K, PRO43K, PRO94I, SER109I, SER110I, SER138K, SER247I, SER24K, SER251I, SER255I, SER256I, SER257I, SER260I, SER28I, SER28K, SER529K, SER534I, SER537I, SER541I, SER578K, SER602I, SER612I, SER65K, SER72K, SER83I, THR122K, THR139K, THR148K, THR168K, THR23K, THR246I, THR258I, THR278I, THR27K, THR29I, THR29K, THR336K, THR44K, THR458K, THR606I, THR610I, THR81I, THR81K, TRP48K, TRP92I, TRP92K, TYR71K, VAL107I, VAL119K, VAL140K, VAL238I, VAL249I, VAL253I, VAL40I, VAL40K, VAL411I, VAL469I, VAL545I, VAL64K, VAL74K
• I-O: ARG625O, ASP197I
• I-Q: ARG147I, ARG147Q, GLN97I, GLN97Q, LYS100I, LYS100Q
• J-K: ALA121J, ALA123J, ALA126J, ALA267J, ALA30K, ALA31K, ALA33K, ALA528J, ALA85K, ARG154J, ARG214J, ARG295J, ARG412K, ARG416K, ARG472K, ARG530J, ARG542K, ARG571J, ARG609J, ARG609K, ARG625J, ARG627J, ARG79J, ARG79K, ASN129J, ASN418K, ASN42J, ASN456J, ASN75J, ASN90K, ASP125J, ASP128J, ASP155J, ASP164J, ASP173J, ASP192J, ASP25K, ASP270K, ASP272K, ASP277K, ASP346K, ASP35K, ASP361J, ASP461J, ASP482K, ASP532K, ASP533K, ASP561K, ASP619J, ASP66J, ASP88K, GLN146J, GLN160J, GLN261J, GLN640J, GLN93K, GLU237K, GLU248K, GLU275K, GLU473K, GLU496J, GLU622J, GLU76J, GLU76K, GLU80K, GLY120J, GLY124J, GLY39J, GLY39K, GLY45J, GLY77J, GLY77K, HIS162J, HIS233K, HIS421K, ILE106K, ILE142J, ILE263J, ILE34K, ILE89K, LEU108K, LEU127J, LEU259J, LEU36K, LEU41J, LEU86K, LYS161J, LYS300J, LYS37J, LYS37K, LYS46J, LYS570J, LYS615J, LYS623J, LYS634J, LYS84K, MET143J, MET26K, MET419K, MET91K, PHE298J, PHE73J, PHE82K, PHE87K, PRO105K, PRO32K, PRO38J, PRO38K, PRO43J, PRO94K, SER109K, SER110K, SER256J, SER257J, SER260J, SER264J, SER28J, SER28K, SER354K, SER529J, SER534K, SER537K, SER541K, SER578J, SER612K, SER72J, SER83K, THR122J, THR139J, THR168J, THR278K, THR29K, THR44J, THR458J, THR610J, THR81K, TRP92K, VAL107K, VAL119J, VAL40J, VAL40K, VAL411K, VAL469K, VAL545K, VAL74J
• J-Q: ARG625J, ASP197Q
• L-P: GLU302P, GLU497P, HIS11L, HIS4L
• L-Q: ALA400Q, GLY44L
• M-O: ALA400O, GLY44M
• M-Q: GLU302Q, GLU497Q, HIS11M, HIS4M
• N-O: GLU302O, GLU497O, HIS11N, HIS4N
• N-P: ALA400P, GLY44N
• O-P: ALA30O, ALA528O, ARG154O, ARG214O, ARG295O, ARG412P, ARG416P, ARG472P, ARG530O, ARG542P, ARG571O, ARG609P, ARG625O, ARG627O, ASN418P, ASN456O, ASP155O, ASP164O, ASP173O, ASP192O, ASP270P, ASP272P, ASP277P, ASP346P, ASP35P, ASP361O, ASP461O, ASP482P, ASP532P, ASP533P, ASP561P, ASP619O, ASP66O, GLN160O, GLN640O, GLU237P, GLU248P, GLU275P, GLU473P, GLU496O, GLU622O, GLU76O, GLU76P, GLU80P, HIS162O, HIS233P, HIS421P, LEU170O, LYS161O, LYS300O, LYS37O, LYS570O, LYS615O, LYS623O, LYS634O, MET169O, MET419P, PHE298O, SER28O, SER354P, SER529O, SER534P, SER537P, SER541P, SER578O, SER612P, THR168O, THR278P, THR27O, THR458O, VAL411P, VAL469P, VAL545P
• O-Q: ALA30Q, ALA528Q, ALA538O, ARG154Q, ARG214Q, ARG295Q, ARG412O, ARG416O, ARG472O, ARG530Q, ARG542O, ARG571Q, ARG609O, ARG625Q, ARG627Q, ASN418O, ASN456Q, ASP155Q, ASP164Q, ASP173Q, ASP192Q, ASP270O, ASP272O, ASP277O, ASP346O, ASP35O, ASP361Q, ASP461Q, ASP482O, ASP532O, ASP533O, ASP561O, ASP619Q, ASP66Q, GLN160Q, GLN640Q, GLU237O, GLU248O, GLU275O, GLU473O, GLU496Q, GLU622Q, GLU76O, GLU76Q, GLU80O, HIS162Q, HIS233O, HIS421O, LYS161Q, LYS300Q, LYS37Q, LYS570Q, LYS615Q, LYS623Q, LYS634Q, LYS84O, MET419O, PHE298Q, SER28Q, SER529Q, SER534O, SER537O, SER541O, SER578Q, SER612O, THR168Q, THR278O, THR27Q, THR336Q, THR44Q, THR458Q, VAL411O, VAL469O, VAL545O
• P-Q: ALA528P, ARG154P, ARG214P, ARG295P, ARG412Q, ARG416Q, ARG472Q, ARG530P, ARG542Q, ARG571P, ARG609Q, ARG625P, ARG627P, ASN418Q, ASN456P, ASP155P, ASP164P, ASP173P, ASP192P, ASP270Q, ASP272Q, ASP277Q, ASP346Q, ASP35Q, ASP361P, ASP461P, ASP482Q, ASP532Q, ASP533Q, ASP561Q, ASP619P, ASP66P, GLN160P, GLN640P, GLU237Q, GLU248Q, GLU275Q, GLU473Q, GLU496P, GLU622P, GLU76P, GLU76Q, GLU80Q, HIS162P, HIS233Q, HIS421Q, LYS161P, LYS300P, LYS37P, LYS570P, LYS615P, LYS623P, LYS634P, MET419Q, PHE298P, SER28P, SER354Q, SER529P, SER534Q, SER537Q, SER541Q, SER578P, SER612Q, THR168P, THR278Q, THR458P, VAL411Q, VAL469Q, VAL545Q
• P-U: ARG625U, ASP197P
• P-W: ARG147P, ARG147W, GLN97W, LYS100P, LYS100W
• Q-W: ARG625Q, ASP197W
• R-V: GLU302V, GLU497V, HIS11R, HIS4R
• R-W: ALA400W, GLY44R
• S-U: ALA400U, GLY44S
• S-W: GLU302W, GLU497W, HIS11S, HIS4S
• T-U: GLU302U, GLU497U, HIS11T, HIS4T
• T-V: ALA400V, GLY44T
• U-V: ALA30U, ALA528U, ARG154U, ARG214U, ARG295U, ARG412V, ARG416V, ARG472V, ARG530U, ARG542V, ARG571U, ARG609V, ARG625U, ARG627U, ASN418V, ASN456U, ASP155U, ASP164U, ASP173U, ASP192U, ASP270V, ASP272V, ASP277V, ASP346V, ASP35V, ASP361U, ASP461U, ASP482V, ASP532V, ASP533V, ASP561V, ASP619U, ASP66U, GLN160U, GLN640U, GLU237V, GLU248V, GLU275V, GLU473V, GLU496U, GLU622U, GLU76U, GLU76V, GLU80V, HIS162U, HIS233V, HIS421V, LEU170U, LYS161U, LYS300U, LYS37U, LYS570U, LYS615U, LYS623U, LYS634U, MET169U, MET419V, PHE298U, SER28U, SER354V, SER529U, SER534V, SER537V, SER541V, SER578U, SER612V, THR168U, THR278V, THR27U, THR458U, VAL411V, VAL469V, VAL545V
• U-W: ALA30W, ALA528W, ALA538U, ARG154W, ARG214W, ARG295W, ARG412U, ARG416U, ARG472U, ARG530W, ARG542U, ARG571W, ARG609U, ARG625W, ARG627W, ASN418U, ASN456W, ASP155W, ASP164W, ASP173W, ASP192W, ASP270U, ASP272U, ASP277U, ASP346U, ASP35U, ASP361W, ASP461W, ASP482U, ASP532U, ASP533U, ASP561U, ASP619W, ASP66W, GLN160W, GLN640W, GLU237U, GLU248U, GLU275U, GLU473U, GLU496W, GLU622W, GLU76U, GLU76W, GLU80U, HIS162W, HIS233U, HIS421U, LYS161W, LYS300W, LYS37W, LYS570W, LYS615W, LYS623W, LYS634W, LYS84U, MET169W, MET419U, PHE298W, SER28W, SER529W, SER537U, SER541U, SER578W, SER612U, THR168W, THR278U, THR27W, THR336W, THR44W, THR458W, VAL411U, VAL469U, VAL545U
• U-X: ARG625X, ASP197U
• V-W: ALA528V, ARG154V, ARG214V, ARG295V, ARG412W, ARG416W, ARG472W, ARG530V, ARG542W, ARG571V, ARG609W, ARG625V, ARG627V, ASN418W, ASN456V, ASP155V, ASP164V, ASP173V, ASP192V, ASP270W, ASP272W, ASP277W, ASP346W, ASP35W, ASP361V, ASP461V, ASP482W, ASP532W, ASP533W, ASP561W, ASP619V, ASP66V, GLN160V, GLN640V, GLU237W, GLU248W, GLU275W, GLU473W, GLU496V, GLU622V, GLU76V, GLU76W, GLU80W, HIS162V, HIS233W, HIS421W, LYS161V, LYS300V, LYS37V, LYS570V, LYS615V, LYS623V, LYS634V, MET419W, PHE298V, SER28V, SER354W, SER529V, SER534W, SER537W, SER541W, SER578V, SER612W, THR168V, THR278W, THR458V, VAL411W, VAL469W, VAL545W
• X-Y: GLN585X, GLU302X, GLU497X, HIS11Y, HIS4Y, VAL586X