3K1F

crystal structure of rna polymerase ii in complex with tfiib

• Total interactions analyzed: 78
• Total true interactions: 31
• Strongest Interaction:
  • Chains: A-B
  • Int. Res.: 784
  • Norm. En. per Res.: -4.6324
• Hub Node: B(11)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-477.3872	-233.1278	-2921.3	-3631.815	784	141	58	113565	34	267	242
A-C	-4.0934	21.5581	-68.7877	-51.323	51	2	0	2748	0	17	19
A-D	-2.3311	-52.5114	-45.3568	-100.1993	37	1	2	2353	4	12	5
A-E	-90.9812	-91.547	-620.24	-802.7683	203	25	14	24279	11	78	62
A-F	-58.2439	-43.2386	-576.56	-678.0425	177	21	16	22902	2	59	57
A-G	-30.612	-73.5254	-160.947	-265.0845	66	9	5	6119	3	21	17
A-H	-42.2404	-17.5553	-451.226	-511.0217	137	29	12	17711	0	33	34
A-I	-94.3727	-59.2571	-463.289	-616.9188	134	29	10	17038	6	45	43
A-K	-23.1001	-23.7332	-264.966	-311.7993	96	9	8	9959	2	22	17
A-M	-79.7806	-13.8516	-456.934	-550.5662	194	30	6	19969	8	34	33
B-C	-100.6559	-94.9497	-512.63	-708.2357	167	35	3	18302	7	54	64
B-D	-7.4997	1.0781	-54.1976	-60.6193	38	5	1	2392	0	16	19
B-E	0.0	0.0	-24.0376	-24.0376	9	0	0	657	0	2	1
B-F	-6.296	-6.3628	-16.2087	-28.8675	25	1	0	685	1	7	8
B-G	0.0	-2.7766	-12.7951	-15.5717	25	0	0	830	0	7	4
B-H	0.0	0.0	-0.2178	-0.2178	2	0	0	35	0	0	0
B-I	-23.8895	-36.2375	-305.307	-365.434	135	17	3	13152	1	53	49
B-J	-44.9236	-0.7612	-451.207	-496.8918	141	17	7	18456	3	35	35
B-K	-11.546	-27.8524	-99.3699	-138.7682	61	7	0	3947	4	16	18
B-L	-74.2573	-66.7621	-273.073	-414.0924	112	16	7	11606	8	43	43
B-M	-49.851	-26.4995	-291.551	-367.9015	177	14	2	14041	3	42	33
C-H	0.0	-6.8431	-26.6586	-33.5017	20	0	1	1191	0	7	5
C-J	-42.1326	-19.2076	-313.049	-374.3892	117	26	9	13408	6	38	28
C-K	-34.6056	-29.307	-542.575	-606.4876	154	30	16	23360	9	45	47
C-L	-62.2423	-26.5605	-179.105	-267.9078	62	9	9	6243	4	25	16
D-G	-80.6053	-18.2687	-675.091	-773.9651	204	21	18	26900	10	55	49
E-F	0.0	-23.7802	-25.3853	-49.1655	20	2	0	1162	1	6	6
F-G	-6.0399	-11.4389	-135.573	-153.0518	54	6	1	5316	1	10	12
H-K	0.0	0.0	-61.2495	-61.2495	26	4	0	2292	0	3	4
J-L	0.0	0.0	-6.1141	-6.1141	9	0	0	309	0	0	1
K-L	0.0	5.8281	-0.9641	4.864	5	0	0	128	0	3	2

Interface residues

• A-B: ALA1016B, ALA1024B, ALA1068A, ALA1069A, ALA1083B, ALA1105B, ALA1107B, ALA1140B, ALA1143B, ALA1144B, ALA1149A, ALA1154B, ALA1157B, ALA1173B, ALA1199B, ALA1200B, ALA1209B, ALA1396A, ALA1412A, ALA1414A, ALA1416A, ALA1434A, ALA1440A, ALA266B, ALA29A, ALA349A, ALA371A, ALA457A, ALA472B, ALA480A, ALA48A, ALA499A, ALA506A, ALA509B, ALA525B, ALA532B, ALA671A, ALA695B, ALA704B, ALA726B, ALA735B, ALA749A, ALA753B, ALA759A, ALA763A, ALA776A, ALA817A, ALA826B, ALA828A, ALA828B, ALA832A, ALA9A, ARG1020B, ARG1067B, ARG1106B, ARG1108B, ARG1116B, ARG1122B, ARG1124B, ARG1129B, ARG1135B, ARG1150B, ARG1159B, ARG1215B, ARG1220B, ARG1222B, ARG12A, ARG1422A, ARG247A, ARG261B, ARG267B, ARG28A, ARG320A, ARG326A, ARG328A, ARG335A, ARG337A, ARG344A, ARG350A, ARG412A, ARG416A, ARG446A, ARG469A, ARG47A, ARG498A, ARG512B, ARG57A, ARG620B, ARG635B, ARG63A, ARG677A, ARG728B, ARG730B, ARG766B, ARG782A, ARG806A, ARG821A, ARG839A, ARG840A, ARG857A, ARG884B, ARG928B, ARG935B, ASN1013B, ASN1074B, ASN1176B, ASN1178B, ASN1211B, ASN1265A, ASN1393A, ASN1427A, ASN253A, ASN339A, ASN358A, ASN445A, ASN471A, ASN479A, ASN488A, ASN516B, ASN538B, ASN548A, ASN64A, ASN654A, ASN660A, ASN741A, ASN742A, ASN757A, ASN75A, ASN762B, ASN767B, ASN802A, ASN834B, ASN858A, ASN862A, ASP1100B, ASP1101B, ASP1125B, ASP1136B, ASP1156B, ASP1186B, ASP1190B, ASP1219B, ASP1223B, ASP1257A, ASP1419A, ASP1420A, ASP260A, ASP305A, ASP346A, ASP356A, ASP397B, ASP399B, ASP414A, ASP481A, ASP483A, ASP485A, ASP526A, ASP544A, ASP618B, ASP62A, ASP668A, ASP672A, ASP694B, ASP724B, ASP760B, ASP781A, ASP790A, ASP791A, ASP826A, ASP837B, ASP847A, ASP921B, ASP936B, ASP978B, ASP998B, CYS1029B, CYS1137B, CYS1163B, CYS1166B, CYS1182B, CYS1185B, CYS1400A, CYS1421A, CYS238A, CYS505A, CYS523B, CYS529A, CYS533B, CYS67A, CYS70A, CYS741B, CYS764A, CYS77A, CYS829B, GLN1065B, GLN1070A, GLN1084B, GLN1112B, GLN1117B, GLN1179B, GLN1193B, GLN1205B, GLN1432A, GLN18A, GLN256A, GLN313A, GLN316A, GLN447A, GLN469B, GLN493A, GLN4A, GLN510A, GLN513B, GLN525A, GLN531B, GLN545A, GLN5A, GLN650A, GLN68A, GLN706B, GLN71A, GLN745A, GLN760A, GLN763B, GLN768A, GLN811A, GLN835B, GLN838A, GLN843B, GLN975B, GLN986B, GLU1028B, GLU1053B, GLU1062A, GLU1070B, GLU1120B, GLU1132B, GLU1134B, GLU1149B, GLU1151A, GLU1153B, GLU1181B, GLU1206B, GLU1264A, GLU1269A, GLU1407A, GLU1411A, GLU1417A, GLU1426A, GLU16A, GLU254A, GLU25A, GLU262B, GLU26A, GLU312B, GLU319B, GLU333A, GLU433A, GLU486A, GLU495A, GLU496A, GLU500A, GLU526B, GLU529B, GLU542A, GLU621B, GLU696B, GLU697B, GLU698B, GLU699B, GLU72A, GLU742B, GLU76A, GLU771A, GLU795A, GLU801A, GLU812A, GLU822A, GLU833A, GLU836B, GLU846A, GLU922B, GLU923B, GLU924B, GLY1061A, GLY1065A, GLY1068B, GLY1075B, GLY1078B, GLY1109B, GLY1121B, GLY1126B, GLY1127B, GLY1131B, GLY1142B, GLY1167B, GLY1184B, GLY1395A, GLY1413A, GLY1423A, GLY1431A, GLY1437A, GLY1439A, GLY20A, GLY263B, GLY319A, GLY331A, GLY334A, GLY338A, GLY342A, GLY355A, GLY3A, GLY402B, GLY484A, GLY520B, GLY530A, GLY530B, GLY534B, GLY661A, GLY665A, GLY667A, GLY673A, GLY73A, GLY750A, GLY750B, GLY753A, GLY778A, GLY79A, GLY807A, GLY819A, GLY820A, GLY823A, GLY82A, GLY832B, GLY835A, GLY861A, GLY94A, GLY977B, GLY985B, GLY988B, GLY991B, HIS1015B, HIS1025B, HIS1076B, HIS1097B, HIS1104B, HIS1141B, HIS1161B, HIS1177B, HIS1195B, HIS1258A, HIS400B, HIS451A, HIS490A, HIS515B, HIS518B, HIS659A, HIS734B, HIS740B, HIS744B, HIS761B, HIS786A, HIS80A, HIS816A, HIS887B, HIS92A, ILE1011B, ILE1012B, ILE1017B, ILE1027B, ILE1050B, ILE1055B, ILE1085B, ILE1103B, ILE1139B, ILE1162B, ILE1165B, ILE1172B, ILE1189B, ILE1191B, ILE1194B, ILE1196B, ILE1212B, ILE1408A, ILE1429A, ILE1436A, ILE235A, ILE250A, ILE30A, ILE325A, ILE336A, ILE353A, ILE370A, ILE406A, ILE436A, ILE463A, ILE523A, ILE541A, ILE619B, ILE61A, ILE666A, ILE670A, ILE679A, ILE683A, ILE693B, ILE701B, ILE703B, ILE729B, ILE743B, ILE748B, ILE756A, ILE756B, ILE758A, ILE775A, ILE825A, ILE827B, ILE840B, ILE846B, ILE848A, ILE870B, ILE918B, ILE976B, ILE990B, ILE992B, LEU1026B, LEU1030B, LEU1031B, LEU1059B, LEU1067A, LEU1081B, LEU1095B, LEU1114B, LEU1128B, LEU1147B, LEU1151B, LEU1168B, LEU1175B, LEU11A, LEU1202B, LEU1203B, LEU1207B, LEU1216B, LEU1268A, LEU1397A, LEU1409A, LEU1418A, LEU1430A, LEU21A, LEU236A, LEU239A, LEU262A, LEU266A, LEU315A, LEU329A, LEU340A, LEU359A, LEU374A, LEU443A, LEU450A, LEU470A, LEU472A, LEU489A, LEU501A, LEU504A, LEU508B, LEU509A, LEU514B, LEU521B, LEU528A, LEU535B, LEU637B, LEU657A, LEU658A, LEU65A, LEU702B, LEU710B, LEU740A, LEU749B, LEU784A, LEU805A, LEU808A, LEU824A, LEU845A, LEU860A, LEU86A, LEU883B, LEU925B, LYS1079B, LYS1080B, LYS1102B, LYS1144A, LYS1148B, LYS1174B, LYS1183B, LYS1201B, LYS1261A, LYS1262A, LYS132A, LYS15A, LYS315B, LYS317A, LYS332A, LYS343A, LYS368A, LYS372A, LYS393B, LYS403A, LYS452A, LYS470B, LYS510B, LYS533A, LYS537B, LYS569A, LYS687A, LYS727B, LYS744A, LYS752A, LYS789A, LYS797A, LYS830A, LYS843A, LYS864B, LYS934B, LYS979B, LYS987B, MET1021B, MET1063A, MET1072B, MET1082B, MET1098B, MET1111B, MET1133B, MET1138B, MET1152B, MET1169B, MET1208B, MET1210B, MET1398A, MET1433A, MET234A, MET304A, MET341A, MET453A, MET455A, MET456A, MET473B, MET487A, MET676A, MET705B, MET746A, MET747B, MET74A, MET761A, MET818A, MET839B, MET849A, PHE1047B, PHE1069B, PHE1086B, PHE1087B, PHE1130B, PHE1146B, PHE1158B, PHE1180B, PHE1204B, PHE1224B, PHE1402A, PHE1410A, PHE1441A, PHE19A, PHE228A, PHE22A, PHE252A, PHE347A, PHE401B, PHE468A, PHE482A, PHE540A, PHE655A, PHE662A, PHE738B, PHE758B, PHE777A, PHE779A, PHE787A, PHE799A, PHE813A, PHE814A, PHE815A, PHE81A, PHE95A, PHE980B, PRO1000B, PRO1014B, PRO1018B, PRO1046B, PRO10A, PRO1110B, PRO1118B, PRO1197B, PRO1214B, PRO1435A, PRO240A, PRO242A, PRO243A, PRO244A, PRO245A, PRO248A, PRO24A, PRO316B, PRO321A, PRO357A, PRO367A, PRO377A, PRO441A, PRO448A, PRO464A, PRO492A, PRO511B, PRO524B, PRO528B, PRO725B, PRO745B, PRO759B, PRO765B, PRO785A, PRO78A, PRO794A, PRO810A, PRO917B, PRO920B, PRO974B, SER1019B, SER1056B, SER1066B, SER1071A, SER1145B, SER1150A, SER1155B, SER1221B, SER1401A, SER1425A, SER229A, SER23A, SER251A, SER255A, SER264B, SER265B, SER318A, SER31A, SER348A, SER354A, SER369A, SER449A, SER454A, SER466A, SER473A, SER474B, SER476A, SER494A, SER663A, SER700B, SER732B, SER746B, SER751A, SER754A, SER762A, SER764B, SER788A, SER793A, SER796A, SER7A, SER803A, SER831B, SER838B, SER859A, SER8A, SER919B, THR1022B, THR1048B, THR1051B, THR1077A, THR1077B, THR1115B, THR1170B, THR1213B, THR1218B, THR1266A, THR1394A, THR13A, THR1405A, THR1438A, THR237A, THR351A, THR373A, THR375A, THR467A, THR46A, THR475A, THR497A, THR517B, THR527A, THR527B, THR539A, THR664A, THR669A, THR680A, THR69A, THR737B, THR739B, THR768B, THR783A, THR809A, THR827A, THR831A, THR834A, THR916B, THR989B, THR993B, TRP233A, TRP308B, TRP519B, TRP552A, TRP656A, TYR1192B, TYR1198B, TYR1217B, TYR303A, TYR376A, TYR404A, TYR417A, TYR459B, TYR465A, TYR6A, TYR769B, TYR804A, TYR830B, TYR833B, TYR836A, TYR866B, TYR994B, VAL1023B, VAL1052B, VAL1064A, VAL1066A, VAL1099B, VAL1113B, VAL1119B, VAL1160B, VAL1171B, VAL1406A, VAL1424A, VAL1428A, VAL14A, VAL17A, VAL227A, VAL241A, VAL246A, VAL27A, VAL2A, VAL300A, VAL322A, VAL32A, VAL345A, VAL352A, VAL366A, VAL405A, VAL442A, VAL491A, VAL507A, VAL522B, VAL524A, VAL536B, VAL723B, VAL731B, VAL743A, VAL747A, VAL765A, VAL770A, VAL780A, VAL800A, VAL829A, VAL842A, VAL93A
• A-C: ALA223C, ALA671A, ASN31C, ASN660A, ASN736A, ASN741A, ASN742A, ASP190C, ASP196C, ASP220C, ASP538A, ASP544A, ASP668A, ASP672A, ASP739A, GLN195C, GLN224C, GLN745A, GLU194C, GLU200C, GLU542A, GLY665A, GLY667A, GLY673A, HIS188C, HIS659A, ILE666A, ILE670A, LEU186C, LEU571A, LEU737A, LEU740A, LYS222C, LYS533A, LYS567A, LYS569A, LYS738A, PHE219C, PRO568A, PRO570A, PRO674A, SER197C, SER663A, THR189C, THR664A, THR669A, TRP192C, TYR191C, TYR193C, TYR221C, VAL743A
• A-D: ALA29A, ALA9A, ARG12A, ARG12D, ARG13D, ARG14D, ARG230A, ASN225A, GLN18A, GLU16A, GLU226A, GLU26A, GLY20A, ILE30A, LEU11A, LEU1418A, LEU15D, LEU21A, LYS15A, LYS16D, LYS17D, PHE228A, PHE22A, PRO10A, SER229A, SER23A, SER4D, SER6D, SER7A, SER8A, THR10D, THR5D, TRP233A, TYR6A, VAL17A, VAL227A, VAL3D
• A-E: ALA1010A, ALA1014A, ALA1137A, ALA127A, ALA1343A, ALA1346A, ALA1347A, ALA1369A, ALA138E, ALA139E, ALA181E, ALA185E, ALA209E, ALA875A, ARG1012A, ARG1023A, ARG11E, ARG1215A, ARG1289A, ARG1326A, ARG1345A, ARG1366A, ARG1422A, ARG14E, ARG162E, ARG167E, ARG169E, ARG177E, ARG180E, ARG192E, ARG200E, ARG207E, ARG212E, ARG7E, ARG857A, ASN1004A, ASN1009A, ASN1364A, ASN1393A, ASN143E, ASN517A, ASN854A, ASN858A, ASN862A, ASN953A, ASP1013A, ASP1323A, ASP1334A, ASP1373A, ASP159E, ASP182E, ASP853A, ASP871A, CYS1019A, CYS1020A, CYS214E, GLN1008A, GLN1011A, GLN1218A, GLN124A, GLN1378A, GLN174E, GLN179E, GLN865A, GLN935A, GLU1005A, GLU1121A, GLU1315A, GLU1337A, GLU1342A, GLU137E, GLU148E, GLU160E, GLU163E, GLU172E, GLU203E, GLU4E, GLU870A, GLU945A, GLU951A, GLY1002A, GLY1275A, GLY1321A, GLY1340A, GLY1344A, GLY1379A, GLY1380A, GLY206E, GLY861A, GLY869A, GLY872A, HIS146E, HIS147E, HIS153E, ILE1006A, ILE1007A, ILE128A, ILE1322A, ILE1327A, ILE1335A, ILE1341A, ILE144E, ILE178E, ILE198E, ILE199E, ILE213E, ILE864A, ILE867A, ILE878A, LEU1000A, LEU1017A, LEU121A, LEU1313A, LEU1339A, LEU1348A, LEU1381A, LEU140E, LEU149E, LEU156E, LEU164E, LEU165E, LEU170E, LEU175E, LEU860A, LEU943A, LEU956A, LYS1003A, LYS122E, LYS129A, LYS1350A, LYS152E, LYS161E, LYS166E, LYS171E, LYS197E, LYS201E, LYS880A, LYS941A, MET1317A, MET1336A, MET1368A, MET1375A, MET215E, MET873A, PHE1018A, PHE1332A, PHE866A, PHE942A, PHE947A, PRO1320A, PRO1324A, PRO151E, PRO176E, PRO183E, PRO955A, PRO957A, SER10E, SER1314A, SER173E, SER202E, SER205E, SER210E, SER859A, THR1016A, THR1117A, THR1318A, THR1325A, THR1329A, THR1376A, THR1377A, THR1382A, THR145E, THR204E, THR855A, THR856A, TRP954A, TYR1119A, TYR1328A, TYR1349A, TYR1353A, TYR1362A, TYR1365A, TYR168E, TYR208E, TYR211E, TYR868A, VAL1015A, VAL1276A, VAL1316A, VAL1319A, VAL1338A, VAL1363A, VAL1372A, VAL1374A, VAL141E, VAL142E, VAL150E, VAL184E, VAL195E, VAL196E, VAL863A, VAL946A, VAL948A
• A-F: ALA1051A, ALA105F, ALA121F, ALA1434A, ALA1440A, ALA499A, ALA80F, ALA876A, ALA91F, ALA98F, ARG1001A, ARG1055A, ARG119F, ARG135F, ARG136F, ARG1422A, ARG387A, ARG498A, ARG79F, ARG857A, ARG90F, ARG92F, ARG97F, ASN1004A, ASN104F, ASN384A, ASN854A, ASN858A, ASP110F, ASP116F, ASP140F, ASP1442A, ASP1446A, ASP145F, ASP154F, ASP77F, ASP853A, ASP874A, CYS505A, GLN100F, GLN1052A, GLN427A, GLN493A, GLN503A, GLN510A, GLN78F, GLU1050A, GLU1062A, GLU114F, GLU124F, GLU127F, GLU1447A, GLU1448A, GLU144F, GLU149F, GLU150F, GLU378A, GLU495A, GLU496A, GLU500A, GLU89F, GLY1002A, GLY1061A, GLY113F, GLY141F, GLY1437A, GLY1439A, GLY429A, GLY861A, GLY95F, HIS1059A, HIS851A, HIS877A, ILE1007A, ILE101F, ILE120F, ILE130F, ILE134F, ILE1436A, ILE1445A, ILE152F, ILE385A, ILE74F, ILE93F, LEU1000A, LEU1054A, LEU1067A, LEU111F, LEU118F, LEU125F, LEU132F, LEU138F, LEU1450A, LEU151F, LEU155F, LEU501A, LEU504A, LEU509A, LEU860A, LEU94F, LEU998A, LEU99F, LYS1003A, LYS128F, LYS129F, LYS1452A, LYS15A, LYS431A, LYS452A, LYS70F, LYS76F, LYS87F, MET103F, MET1063A, MET122F, MET1433A, MET1444A, MET1454A, MET437A, MET849A, MET85F, PHE108F, PHE143F, PHE1441A, PRO1060A, PRO106F, PRO117F, PRO131F, PRO139F, PRO1435A, PRO1455A, PRO382A, PRO441A, PRO514A, PRO639A, PRO83F, SER102F, SER142F, SER1449A, SER147F, SER494A, SER502A, THR115F, THR1438A, THR381A, THR497A, THR81F, THR82F, THR855A, THR856A, THR86F, THR96F, TRP146F, TRP430A, TYR137F, TYR1453A, TYR376A, TYR383A, TYR428A, TYR84F, TYR852A, TYR88F, VAL1057A, VAL1058A, VAL1064A, VAL107F, VAL109F, VAL133F, VAL1443A, VAL1451A, VAL148F, VAL153F, VAL379A, VAL380A, VAL850A, VAL863A, VAL999A
• A-G: ALA68G, ARG12A, ARG21G, ARG58G, ARG60G, ASN10G, ASN71G, ASP1442A, ASP1446A, ASP65G, GLN1432A, GLN24G, GLN57G, GLU1447A, GLU1448A, GLU495A, GLU496A, GLU69G, GLY1439A, GLY19G, GLY429A, GLY59G, GLY66G, HIS14G, ILE1445A, ILE56G, ILE61G, LEU11A, LEU13G, LEU1450A, LEU26G, LEU62G, LEU9G, LYS1452A, LYS15A, LYS23G, LYS27G, LYS431A, MET1433A, MET1444A, MET1454A, MET22G, PHE1441A, PHE17G, PHE18G, PHE70G, PRO10A, PRO1455A, PRO15G, PRO20G, PRO63G, SER1449A, SER16G, SER494A, SER67G, THR12G, THR13A, THR1438A, THR497A, THR64G, TYR1453A, TYR428A, VAL1443A, VAL1451A, VAL2A, VAL379A
• A-H: ALA101H, ALA140H, ALA564A, ARG1036A, ARG124H, ARG19H, ARG25H, ARG537A, ARG77H, ARG80H, ASN139H, ASN21H, ASN43H, ASN603A, ASN736A, ASN741A, ASP16H, ASP41H, ASP538A, ASP557A, ASP602A, ASP609A, ASP739A, ASP91H, ASP94H, ASP974A, CYS24H, GLN576A, GLN589A, GLN611A, GLN745A, GLU105H, GLU106H, GLU138H, GLU27H, GLU45H, GLY119H, GLY120H, GLY18H, GLY558A, GLY574A, GLY615A, GLY99H, HIS587A, HIS972A, HIS975A, ILE112H, ILE144H, ILE26H, ILE42H, ILE541A, ILE560A, ILE565A, ILE566A, ILE577A, ILE608A, ILE612A, ILE613A, ILE973A, LEU121H, LEU122H, LEU125H, LEU142H, LEU143H, LEU38H, LEU40H, LEU46H, LEU536A, LEU543A, LEU547A, LEU550A, LEU571A, LEU597A, LEU598A, LEU606A, LEU63H, LEU737A, LEU740A, LEU89H, LYS103H, LYS136H, LYS22H, LYS567A, LYS569A, LYS575A, LYS601A, LYS738A, LYS744A, LYS977A, MET123H, MET748A, MET97H, PHE104H, PHE118H, PHE47H, PHE540A, PHE591A, PHE614A, PRO48H, PRO561A, PRO563A, PRO568A, PRO570A, PRO600A, PRO81H, PRO82H, SER117H, SER573A, SER579A, SER599A, SER78H, THR100H, THR39H, THR535A, THR539A, THR562A, THR596A, THR76H, THR976A, TRP556A, TRP572A, TRP656A, TRP79H, TYR102H, TYR115H, TYR116H, TYR141H, TYR20H, TYR93H, TYR95H, TYR98H, VAL114H, VAL23H, VAL44H, VAL559A, VAL616A, VAL96H
• A-I: ALA1149A, ALA1201A, ALA38I, ALA697A, ALA699A, ALA704A, ARG1194A, ARG17I, ARG24I, ARG30I, ARG45I, ARG70I, ARG711A, ARG73I, ARG782A, ARG91I, ARG92I, ASN116I, ASN1265A, ASN22I, ASN23I, ASN51I, ASN700A, ASP113I, ASP1155A, ASP1157A, ASP1198A, ASP1257A, ASP19I, ASP65I, ASP781A, ASP790A, ASP791A, ASP94I, GLN114I, GLN698A, GLN87I, GLN89I, GLN90I, GLU1151A, GLU1196A, GLU1256A, GLU1264A, GLU1269A, GLU18I, GLU47I, GLU54I, GLU696A, GLU712A, GLU715A, HIS1258A, HIS46I, ILE1148A, ILE1152A, ILE1163A, ILE49I, ILE62I, LEU1143A, LEU1192A, LEU1193A, LEU1195A, LEU1197A, LEU1260A, LEU1268A, LEU25I, LEU26I, LEU42I, LEU48I, LEU68I, LEU701A, LEU702A, LEU710A, LEU99I, LYS1144A, LYS115I, LYS117I, LYS1235A, LYS1261A, LYS20I, LYS695A, LYS789A, LYS797A, LYS93I, MET708A, MET97I, PHE100I, PHE101I, PHE27I, PHE714A, PHE777A, PHE779A, PHE787A, PHE85I, PHE86I, PRO1156A, PRO1190A, PRO16I, PRO41I, PRO66I, PRO69I, PRO785A, SER112I, SER1145A, SER1150A, SER40I, SER713A, SER71I, SER788A, SER88I, SER96I, THR111I, THR1147A, THR1161A, THR2I, THR50I, THR67I, THR694A, THR703A, THR709A, THR95I, TRP1191A, TYR1153A, TYR1154A, TYR15I, TYR44I, TYR792A, VAL1146A, VAL1162A, VAL43I, VAL693A, VAL718A, VAL780A, VAL84I, VAL98I
• A-K: ALA27K, ALA30K, ALA371A, ALA3K, ALA48K, ALA59K, ALA60K, ARG469A, ARG47K, ARG6K, ARG70K, ARG74K, ASN2K, ASN358A, ASN44K, ASN548A, ASN648A, ASP24K, ASP356A, ASP544A, ASP555A, ASP557A, ASP5K, GLN545A, GLN76K, GLU542A, GLU64K, GLU8K, GLY355A, GLY365A, GLY558A, GLY647A, HIS40K, HIS659A, HIS65K, ILE33K, ILE370A, ILE463A, ILE560A, ILE75K, LEU359A, LEU50K, LEU51K, LEU543A, LEU547A, LEU550A, LEU57K, LEU658A, LEU73K, LEU9K, LYS26K, LYS368A, LYS372A, LYS461A, LYS62K, LYS644A, LYS651A, LYS72K, MET1K, MET549A, PHE58K, PHE655A, PHE67K, PHE68K, PHE71K, PRO28K, PRO357A, PRO367A, PRO464A, PRO4K, PRO554A, PRO561A, PRO66K, SER354A, SER369A, SER466A, THR25K, THR34K, THR351A, THR373A, THR467A, TRP552A, TRP556A, TYR465A, TYR551A, TYR61K, VAL31K, VAL32K, VAL366A, VAL462A, VAL546A, VAL553A, VAL559A, VAL56K, VAL63K, VAL652A
• A-M: ALA267A, ALA272A, ALA288A, ALA292A, ALA309A, ALA314A, ALA421A, ALA46M, ARG13M, ARG257A, ARG320A, ARG37M, ARG407A, ARG412A, ARG416A, ARG420A, ARG47A, ARG60M, ARG63A, ARG64M, ASN17M, ASN19M, ASN253A, ASN306A, ASN64A, ASN68M, ASN75A, ASP177A, ASP260A, ASP261A, ASP268A, ASP346A, ASP411A, ASP414A, ASP42A, ASP42M, ASP54M, ASP55A, ASP58M, ASP62A, CYS27M, CYS45M, CYS48M, CYS67A, CYS70A, GLN256A, GLN311A, GLN313A, GLN316A, GLN45A, GLN4A, GLN68A, GLN71A, GLU254A, GLU259A, GLU26M, GLU290A, GLU291A, GLU293A, GLU36M, GLU39A, GLU40M, GLU43A, GLU62M, GLU72A, GLU76A, GLY178A, GLY258A, GLY310A, GLY319A, GLY3A, GLY410A, GLY41M, GLY49M, GLY73A, HIS299A, ILE20M, ILE250A, ILE269A, ILE289A, ILE308A, ILE406A, ILE413A, ILE424A, ILE50A, LEU179A, LEU18M, LEU22M, LEU262A, LEU266A, LEU270A, LEU279A, LEU295A, LEU296A, LEU315A, LEU415A, LEU47M, LEU50M, LEU52M, LEU53A, LEU56M, LEU65A, LYS265A, LYS271A, LYS317A, LYS323A, LYS33M, LYS403A, LYS419A, LYS55M, LYS66A, MET41A, MET74A, PHE252A, PHE264A, PHE298A, PHE38M, PHE66M, PRO16M, PRO248A, PRO25M, PRO312A, PRO321A, PRO38A, SER249A, SER251A, SER255A, SER275A, SER294A, SER318A, SER39M, SER409A, SER418A, SER53M, SER60A, SER61M, SER67M, THR263A, THR278A, THR302A, THR373A, THR40A, THR59M, THR65M, THR69A, TRP63M, TYR404A, TYR417A, UNK102M, UNK103M, UNK104M, UNK105M, UNK106M, UNK107M, UNK108M, UNK109M, UNK110M, UNK111M, UNK112M, UNK113M, UNK114M, UNK115M, UNK116M, UNK117M, UNK118M, UNK119M, UNK120M, UNK121M, UNK122M, UNK84M, UNK85M, UNK86M, UNK87M, UNK88M, UNK89M, UNK90M, UNK91M, UNK92M, UNK93M, UNK94M, UNK95M, UNK96M, UNK97M, UNK98M, UNK99M, VAL21M, VAL2A, VAL322A, VAL35M, VAL405A, VAL43M, VAL44M, VAL51M, VAL57M
• B-C: ALA1003B, ALA1083B, ALA164C, ALA168C, ALA173C, ALA174C, ALA175C, ALA198C, ALA225C, ALA28C, ALA30C, ALA39C, ALA59C, ALA64C, ARG1060B, ARG1067B, ARG148C, ARG34C, ARG35C, ARG66C, ARG848B, ARG852B, ARG904B, ARG969B, ARG995B, ARG996B, ASN1074B, ASN184C, ASN206C, ASN231C, ASN31C, ASN54C, ASN786B, ASN842B, ASP181C, ASP190C, ASP196C, ASP60C, ASP847B, ASP950B, ASP998B, GLN1065B, GLN1084B, GLN195C, GLN203C, GLN224C, GLN843B, GLU1004B, GLU1053B, GLU1070B, GLU166C, GLU177C, GLU179C, GLU194C, GLU200C, GLU233C, GLU40C, GLU50C, GLU61C, GLU997B, GLY1005B, GLY1063B, GLY1068B, GLY1075B, GLY1078B, GLY171C, GLY68C, GLY849B, GLY902B, GLY947B, HIS1076B, HIS167C, HIS188C, HIS65C, ILE1006B, ILE1085B, ILE144C, ILE163C, ILE176C, ILE38C, ILE63C, ILE795B, ILE846B, ILE948B, ILE973B, LEU1081B, LEU186C, LEU27C, LEU58C, LEU67C, LEU69C, LEU796B, LEU850B, LEU854B, LYS1079B, LYS1080B, LYS149C, LYS165C, LYS169C, LYS185C, LYS187C, LYS191B, LYS193B, LYS199C, LYS254C, LYS972B, MET1072B, MET1082B, MET230C, MET37C, MET999B, PHE1001B, PHE1069B, PHE1086B, PHE178C, PHE228C, PHE62C, PHE855B, PHE856B, PRO1000B, PRO172C, PRO182C, PRO202C, PRO799B, PRO901B, SER1056B, SER1066B, SER187B, SER197C, SER204C, SER32C, SER48C, SER844B, SER845B, SER853B, THR1002B, THR1077B, THR189C, THR56C, THR783B, THR970B, THR971B, TRP170C, TRP183C, TRP192C, TRP201C, TYR1064B, TYR1073B, TYR180C, TYR190B, TYR191C, TYR193C, TYR229C, TYR785B, TYR797B, TYR798B, TYR830B, TYR994B, VAL1007B, VAL1071B, VAL235C, VAL36C, VAL49C, VAL51C, VAL57C, VAL949B, VAL968B
• B-D: ARG11D, ARG1215B, ARG1220B, ARG1222B, ARG12D, ARG13D, ARG14D, ASN1187B, ASP1186B, ASP1190B, ASP1219B, ASP1223B, CYS1163B, CYS1166B, CYS1182B, CYS1185B, GLN1193B, GLU20D, GLY1164B, GLY1167B, GLY1184B, ILE1165B, ILE1189B, LEU1168B, LEU1216B, LEU15D, LYS1183B, LYS16D, LYS17D, SER1221B, SER4D, SER6D, THR10D, THR1213B, THR1218B, TYR1192B, TYR1217B, VAL3D
• B-E: ARG1222B, ARG169E, ASP1223B, GLN174E, GLU172E, LEU170E, LYS171E, PHE1224B, SER173E
• B-F: ALA1140B, ALA1143B, ALA1144B, ALA91F, ARG1220B, ARG92F, ASP1223B, ASP140F, GLY1142B, GLY141F, GLY95F, HIS1141B, ILE1139B, LEU69F, LEU99F, LYS1148B, LYS72F, LYS87F, MET1138B, PHE1224B, PRO139F, SER1145B, SER142F, THR96F, TYR88F
• B-G: ALA1144B, ARG60G, ASN10G, ASP1190B, ASP65G, GLN1179B, GLU1149B, GLU1153B, GLY40G, HIS1177B, HIS1195B, ILE1189B, LEU62G, LYS1148B, LYS1188B, LYS41G, MET1152B, PHE42G, PRO63G, SER1145B, SER152G, THR39G, THR64G, TYR1192B, VAL154G
• B-H: LYS22H, MET1082B
• B-I: ALA56I, ALA577B, ALA594B, ALA735B, ARG267B, ARG287B, ARG30I, ARG392B, ARG45I, ARG591B, ARG595B, ARG5I, ARG601B, ARG617B, ARG620B, ARG70I, ARG91I, ARG92I, ASN11I, ASN12I, ASN306B, ASN51I, ASN592B, ASP294B, ASP304B, ASP307B, ASP320B, ASP391B, ASP394B, ASP576B, ASP618B, ASP61I, ASP65I, ASP9I, CYS10I, CYS29I, CYS32I, CYS388B, CYS7I, GLN309B, GLN325B, GLN60I, GLN87I, GLN89I, GLN90I, GLU262B, GLU296B, GLU299B, GLU312B, GLU319B, GLU47I, GLU54I, GLU621B, GLU623B, GLU641B, GLU698B, GLU699B, GLY263B, GLY295B, GLY321B, GLY53I, GLY57I, GLY63I, HIS46I, HIS734B, HIS740B, ILE291B, ILE292B, ILE297B, ILE52I, ILE619B, ILE62I, ILE701B, ILE703B, LEU104I, LEU14I, LEU298B, LEU311B, LEU314B, LEU387B, LEU390B, LEU42I, LEU48I, LEU68I, LEU702B, LEU99I, LYS227B, LYS315B, LYS393B, LYS622B, LYS649B, LYS93I, MET13I, MET310B, MET313B, MET597B, PHE100I, PHE27I, PHE322B, PHE4I, PHE6I, PHE738B, PHE85I, PHE86I, PRO16I, PRO293B, PRO316B, PRO575B, PRO593B, PRO66I, PRO69I, SER264B, SER265B, SER64I, SER700B, SER71I, SER88I, THR2I, THR31I, THR3I, THR50I, THR578B, THR67I, THR736B, THR737B, THR739B, TRP308B, TYR15I, TYR44I, VAL305B, VAL318B, VAL43I, VAL58I, VAL59I, VAL84I
• B-J: ALA1035B, ALA1036B, ALA35J, ALA823B, ARG43J, ARG47J, ARG48J, ARG62J, ARG6J, ARG788B, ARG815B, ARG848B, ARG852B, ARG996B, ASN1040B, ASN64J, ASN784B, ASN786B, ASN822B, ASN842B, ASP1009B, ASP188B, ASP198B, ASP31J, ASP55J, ASP847B, CYS10J, CYS195B, CYS45J, CYS46J, CYS7J, GLN115B, GLN800B, GLN821B, GLU1004B, GLU1041B, GLU1070B, GLU186B, GLU194B, GLU32J, GLU58J, GLU816B, GLY1005B, GLY1039B, GLY1042B, GLY1068B, GLY1088B, GLY11J, GLY33J, GLY779B, GLY804B, GLY820B, GLY849B, HIS1062B, HIS53J, ILE1006B, ILE2J, ILE50J, ILE57J, ILE795B, ILE824B, ILE846B, LEU1010B, LEU1037B, LEU1059B, LEU189B, LEU192B, LEU25J, LEU36J, LEU41J, LEU51J, LEU56J, LEU61J, LEU782B, LEU796B, LEU803B, LEU817B, LEU850B, LEU854B, LYS1033B, LYS12J, LYS191B, LYS193B, LYS42J, LYS59J, LYS801B, LYS813B, MET1072B, MET1J, MET49J, MET999B, PHE1087B, PHE197B, PHE60J, PHE781B, PHE814B, PHE851B, PHE856B, PHE8J, PRO1008B, PRO1089B, PRO196B, PRO4J, PRO65J, PRO799B, PRO802B, PRO818B, SER1032B, SER1038B, SER187B, SER37J, SER844B, SER845B, SER9J, THR1002B, THR1090B, THR185B, THR34J, THR52J, THR783B, THR805B, TRP18J, TYR1064B, TYR1091B, TYR190B, TYR21J, TYR44J, TYR63J, TYR785B, TYR797B, TYR798B, VAL1007B, VAL1034B, VAL13J, VAL14J, VAL3J, VAL54J, VAL5J, VAL780B, VAL787B, VAL825B
• B-K: ALA3K, ALA48K, ALA69K, ARG1122B, ARG47K, ARG6K, ARG848B, ARG995B, ARG996B, ASN1074B, ASN2K, ASN44K, ASN842B, ASN946B, ASP1100B, ASP1101B, ASP39K, ASP847B, ASP998B, GLN843B, GLN975B, GLU38K, GLU64K, GLU997B, GLY1075B, GLY1078B, GLY43K, GLY991B, HIS1076B, HIS1104B, HIS40K, HIS65K, ILE1103B, ILE840B, ILE846B, ILE973B, ILE976B, ILE992B, LEU45K, LEU9K, LYS1079B, LYS972B, MET1K, PHE10K, PHE67K, PHE68K, PRO4K, PRO66K, PRO974B, SER831B, SER844B, SER845B, THR1077B, THR41K, THR944B, THR993B, TYR61K, TYR833B, TYR994B, VAL1099B, VAL63K
• B-L: ALA111B, ALA32L, ALA45L, ALA59L, ALA69L, ALA900B, ARG120B, ARG42L, ARG47L, ARG54L, ARG60L, ARG63L, ARG70L, ARG852B, ARG904B, ARG967B, ARG969B, ASN103B, ASN786B, ASN957B, ASP106B, ASP44L, ASP847B, ASP891B, ASP894B, ASP895B, ASP896B, ASP950B, CYS31L, CYS34L, CYS51L, GLN115B, GLN66L, GLN951B, GLN958B, GLU104B, GLU116B, GLU33L, GLU68L, GLU863B, GLU875B, GLY107B, GLY52L, GLY849B, GLY897B, GLY902B, GLY947B, GLY960B, HIS110B, HIS53L, ILE30L, ILE55L, ILE846B, ILE899B, ILE948B, ILE973B, LEU112B, LEU119B, LEU122B, LEU192B, LEU27L, LEU38L, LEU40L, LEU56L, LEU57L, LEU893B, LEU898B, LEU953B, LEU961B, LYS191B, LYS193B, LYS28L, LYS58L, LYS62L, LYS876B, LYS892B, LYS934B, LYS962B, LYS965B, MET789B, PHE67L, PHE874B, PHE963B, PRO877B, PRO901B, SER105B, SER35L, SER41L, THR109B, THR43L, THR61L, THR873B, THR915B, THR955B, THR956B, THR970B, THR971B, TYR113B, TYR29L, TYR797B, VAL102B, VAL108B, VAL46L, VAL65L, VAL787B, VAL903B, VAL905B, VAL949B, VAL952B, VAL954B, VAL964B, VAL966B
• B-M: ALA1105B, ALA1107B, ALA1157B, ALA1199B, ALA447B, ALA450B, ALA46M, ALA472B, ALA930B, ALA937B, ARG1106B, ARG1108B, ARG1116B, ARG1124B, ARG1159B, ARG13M, ARG169B, ARG37M, ARG430B, ARG60M, ARG64M, ARG879B, ARG884B, ARG928B, ARG935B, ASN103B, ASN19M, ASN449B, ASN68M, ASN957B, ASP106B, ASP1125B, ASP1156B, ASP42M, ASP54M, ASP58M, ASP861B, ASP921B, ASP936B, ASP959B, GLN1112B, GLN1117B, GLN862B, GLN927B, GLN958B, GLU104B, GLU1120B, GLU36M, GLU40M, GLU437B, GLU62M, GLU863B, GLU872B, GLU908B, GLU922B, GLU923B, GLU924B, GLY107B, GLY1109B, GLY41M, GLY867B, GLY888B, GLY926B, GLY960B, HIS887B, ILE20M, ILE34M, ILE448B, ILE870B, ILE918B, LEU1114B, LEU22M, LEU52M, LEU56M, LEU883B, LEU925B, LEU961B, LYS33M, LYS451B, LYS458B, LYS55M, LYS864B, LYS865B, LYS886B, LYS914B, MET1111B, MET868B, MET885B, PHE1158B, PHE166B, PHE38M, PHE66M, PRO1110B, PRO1118B, PRO1197B, PRO31M, PRO32M, PRO940B, SER105B, SER1155B, SER39M, SER53M, SER61M, SER67M, SER869B, SER938B, SER943B, THR1115B, THR23M, THR452B, THR454B, THR463B, THR59M, THR65M, THR871B, THR889B, THR916B, THR929B, THR939B, TRP63M, TYR1198B, TYR30M, TYR431B, TYR459B, TYR866B, TYR931B, UNK131M, UNK133M, UNK134M, UNK135M, UNK136M, UNK137M, UNK138M, UNK139M, UNK140M, UNK141M, UNK142M, UNK143M, UNK144M, UNK145M, UNK146M, UNK147M, UNK148M, UNK149M, UNK150M, UNK151M, UNK152M, UNK153M, UNK154M, UNK156M, UNK175M, UNK177M, UNK178M, UNK179M, UNK180M, UNK181M, UNK182M, UNK183M, UNK184M, UNK185M, UNK186M, UNK195M, UNK197M, UNK214M, UNK87M, UNK88M, UNK98M, VAL108B, VAL1113B, VAL1119B, VAL21M, VAL29M, VAL35M, VAL43M, VAL44M, VAL51M, VAL57M
• C-H: ARG19H, ASN21H, ASN43H, ASP190C, ASP217C, ASP220C, GLU45H, HIS188C, LEU186C, LEU46H, LYS187C, LYS222C, LYS22H, PHE219C, PHE47H, PRO218C, PRO48H, TYR193C, TYR221C, VAL44H
• C-J: ALA164C, ALA168C, ALA173C, ALA174C, ALA175C, ALA45C, ALA59C, ARG148C, ARG43J, ARG62J, ARG66C, ARG6J, ASN112C, ASN140C, ASN17C, ASN231C, ASN23J, ASN64J, ASP136C, ASP16C, ASP16J, ASP19C, ASP28J, ASP55J, CYS10J, CYS145C, CYS45J, CYS46J, CYS7J, GLN135C, GLN151C, GLU138C, GLU177C, GLU19J, GLU233C, GLU27J, GLU58J, GLY105C, GLY11J, GLY139C, GLY141C, GLY150C, GLY15J, GLY171C, GLY236C, GLY40J, GLY68C, HIS167C, HIS53J, HIS65C, ILE133C, ILE134C, ILE144C, ILE176C, ILE2J, ILE38C, ILE57J, ILE63C, ILE70C, LEU143C, LEU147C, LEU22J, LEU24J, LEU39J, LEU41J, LEU44C, LEU56J, LEU58C, LEU61J, LEU67C, LEU69C, LEU72C, LYS116C, LYS12J, LYS137C, LYS146C, LYS149C, LYS15C, LYS169C, LYS17J, LYS42J, LYS59J, MET1J, PHE60J, PHE62C, PHE8J, PRO172C, PRO4J, PRO65J, PRO71C, SER109C, SER115C, SER14C, SER20J, SER234C, SER237C, SER9J, THR110C, THR111C, THR43C, THR55C, THR56C, TRP170C, TRP18J, TYR114C, TYR21J, TYR63J, VAL113C, VAL13J, VAL142C, VAL14J, VAL18C, VAL232C, VAL235C, VAL3J, VAL57C, VAL5J
• C-K: ALA100K, ALA13C, ALA164C, ALA168C, ALA256C, ALA261C, ALA28C, ALA30C, ALA39C, ALA48K, ALA69K, ALA86K, ALA90K, ARG11C, ARG246C, ARG34C, ARG35C, ARG47K, ARG6K, ARG84C, ASN104K, ASN110K, ASN17C, ASN24C, ASN31C, ASN44K, ASN52K, ASN89K, ASN92K, ASN96K, ASP19C, ASP22K, ASP241C, ASP249C, ASP266C, ASP268C, ASP26C, ASP39K, ASP5K, ASP82K, ASP85C, ASP85K, CYS91K, GLN112K, GLN224C, GLN242C, GLN252C, GLN264C, GLN267C, GLN7C, GLU106K, GLU108K, GLU12C, GLU166C, GLU38K, GLU3C, GLU40C, GLU49K, GLU4C, GLU8K, GLY162C, GLY247C, GLY43K, GLY5C, GLY99K, HIS167C, HIS40K, ILE10C, ILE163C, ILE21C, ILE21K, ILE248C, ILE258C, ILE33K, ILE46K, ILE75K, ILE94K, ILE95K, LEU101K, LEU111K, LEU114K, LEU11K, LEU12K, LEU19K, LEU22C, LEU251C, LEU259C, LEU260C, LEU262C, LEU27C, LEU33C, LEU42K, LEU45K, LEU51K, LEU73K, LEU87K, LEU98K, LEU9K, LYS102K, LYS15C, LYS161C, LYS165C, LYS169C, LYS18K, LYS20K, LYS253C, LYS254C, LYS37K, LYS84K, LYS88K, LYS97K, LYS9C, MET265C, MET29C, MET37C, PHE105K, PHE10K, PHE20C, PHE228C, PHE35K, PHE71K, PHE7K, PRO239C, PRO6C, PRO83K, SER14C, SER17K, SER23C, SER257C, SER32C, SER93K, THR103K, THR107K, THR113K, THR250C, THR263C, THR34K, THR41K, TRP109K, TRP170C, TYR61K, TYR82C, VAL18C, VAL232C, VAL240C, VAL243C, VAL244C, VAL245C, VAL255C, VAL25C, VAL31K, VAL36C, VAL63K, VAL8C
• C-L: ALA159C, ALA168C, ALA25L, ALA32L, ALA45C, ALA59C, ALA64C, ALA69L, ARG60L, ARG63L, ARG66C, ARG70L, ARG84C, ASN54C, ASP47C, ASP60C, ASP90C, CYS157C, CYS34L, GLN66L, GLU166C, GLU33L, GLU50C, GLU52C, GLU61C, GLU68L, GLY162C, GLY68C, HIS167C, HIS65C, HIS91C, ILE163C, ILE30L, ILE46C, ILE63C, ILE70C, LEU153C, LEU155C, LEU27L, LEU64L, LEU67C, LEU69C, LYS149C, LYS154C, LYS160C, LYS161C, LYS169C, LYS62L, PHE62C, PHE67L, SER35L, SER48C, THR156C, THR53C, THR55C, THR56C, THR61L, TRP170C, VAL158C, VAL49C, VAL51C, VAL65L
• D-G: ALA178D, ALA184D, ALA188D, ALA191D, ALA24D, ALA25D, ALA49D, ALA55D, ALA62D, ALA69D, ALA76G, ARG119D, ARG11D, ARG142G, ARG144G, ARG153D, ARG21G, ARG56D, ARG66D, ARG67D, ARG68D, ARG72D, ARG75G, ASN10G, ASN137D, ASN138D, ASN143D, ASN150D, ASN23D, ASN39D, ASN51D, ASN53G, ASN71G, ASP140D, ASP166G, ASP186D, ASP189D, ASP50G, ASP52G, ASP55G, ASP6G, ASP88G, CYS150G, CYS185D, CYS38G, CYS47G, GLN102G, GLN146D, GLN179D, GLN24G, GLN28D, GLN31D, GLN34D, GLN37D, GLN41D, GLN57G, GLN74D, GLN9D, GLU148G, GLU165G, GLU176D, GLU190D, GLU20D, GLU22D, GLU32D, GLU32G, GLU33G, GLU35G, GLU43D, GLU45D, GLU46D, GLU54D, GLU61D, GLU65D, GLU69G, GLU85G, GLY104G, GLY135D, GLY149G, GLY169G, GLY181D, GLY30D, GLY36G, GLY40G, GLY42D, GLY43G, GLY84G, GLY89G, HIS173D, HIS40D, ILE11G, ILE143G, ILE147G, ILE157G, ILE171G, ILE195D, ILE38D, ILE45G, ILE48D, ILE4G, ILE54G, ILE59D, LEU123D, LEU130D, LEU141D, LEU148D, LEU168G, LEU180D, LEU183D, LEU194D, LEU27D, LEU29D, LEU30G, LEU31G, LEU35D, LEU46G, LEU47D, LEU49G, LEU50D, LEU52D, LEU57D, LEU63D, LEU7G, LEU9G, LYS107G, LYS139D, LYS140G, LYS142D, LYS146G, LYS192D, LYS27G, LYS29G, LYS36D, LYS41G, LYS5G, LYS60D, LYS73G, LYS76D, LYS80G, LYS83G, MET106G, MET145D, MET1G, PHE151D, PHE175D, PHE2G, PHE33D, PHE3G, PHE42G, PHE70D, PHE70G, PHE79G, PHE82G, PHE8D, PRO105G, PRO174D, PRO196D, PRO81G, SER141G, SER152D, SER155G, SER156G, SER182D, SER197D, SER37G, SER4D, SER53D, SER6D, SER73D, SER8G, THR10D, THR12G, THR133D, THR134D, THR144D, THR149D, THR187D, THR193D, THR26D, THR28G, THR39G, THR5D, THR7D, THR90G, TYR147D, TYR167G, TYR221D, TYR44G, TYR51G, TYR74G, VAL101G, VAL103G, VAL145G, VAL177D, VAL34G, VAL3D, VAL48G, VAL58D, VAL72G, VAL77G, VAL78G, VAL86G, VAL87G, VAL91G
• E-F: ALA80F, ARG167E, ARG169E, ARG79F, ASP140F, GLN174E, GLN78F, GLU144F, GLY141F, ILE74F, LEU138F, LEU165E, LEU170E, LYS171E, LYS72F, PHE143F, PRO139F, SER142F, THR81F, TYR168E
• F-G: ALA105F, ALA68G, ALA73F, ALA98F, ARG135F, ARG58G, ARG60G, ARG79F, ARG92F, ARG97F, ASN104F, ASP145F, ASP65G, GLN100F, GLN57G, GLU144F, GLU150F, GLY19G, GLY59G, GLY66G, GLY95F, HIS14G, ILE101F, ILE134F, ILE61G, ILE93F, LEU132F, LEU13G, LEU62G, LEU99F, LYS70F, LYS73G, LYS76F, MET103F, MET22G, PHE108F, PHE143F, PHE17G, PHE18G, PRO106F, PRO131F, PRO15G, PRO20G, PRO63G, SER102F, SER147F, SER16G, SER67G, THR64G, THR96F, TRP146F, TYR137F, VAL107F, VAL133F
• H-K: ALA27K, ALA84H, ARG54K, ARG74K, ARG80H, ARG87H, ASN29K, ASP53K, GLN76K, GLN83H, GLU79K, GLY80K, GLY85H, LEU57K, LYS26K, LYS55K, PHE58K, PRO28K, PRO81H, PRO82H, SER78H, THR77K, THR78K, TRP79H, TYR81K, VAL56K
• J-L: ALA32L, ASN64J, CYS31L, CYS34L, GLU33L, ILE30L, LEU57L, PRO65J, SER35L
• K-L: ARG6K, ARG70L, ASP5K, PHE10K, PHE7K