3K09

crystal structure of the phosphorylation-site mutant s431d of the kaic circadian clock protein

• Total interactions analyzed: 15
• Total true interactions: 12
• Strongest Interaction:
  • Chains: B-C
  • Int. Res.: 316
  • Norm. En. per Res.: -3.5047
• Hub Node: A(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-102.3824	-130.0522	-764.667	-997.1015	321	59	5	33655	16	139	126
A-D	0.0	0.0	-0.0003	-0.0003	2	0	0	1	0	0	0
A-E	0.0	0.0	-0.0106	-0.0106	2	0	0	9	0	0	0
A-F	-140.0925	-181.8739	-779.711	-1101.6774	324	65	4	33874	18	142	126
B-C	-127.0643	-200.383	-780.044	-1107.4914	316	58	4	33561	16	135	119
B-D	0.0	0.0	-0.0386	-0.0386	2	0	0	18	0	0	0
B-E	0.0	0.0	-0.0003	-0.0003	2	0	0	1	0	0	0
B-F	0.0	0.0	-0.0152	-0.0152	2	0	0	8	0	0	0
C-D	-108.2917	-176.5738	-782.802	-1067.6676	306	57	5	33503	16	133	117
C-E	0.0	0.0	-0.036	-0.036	3	0	0	14	0	0	0
D-E	-114.737	-123.1716	-759.553	-997.4616	311	59	4	32506	14	132	115
E-F	-105.1718	-138.1702	-730.76	-974.102	314	61	4	32374	16	130	113

Interface residues

• A-B: ALA156B, ALA169B, ALA17B, ALA192B, ALA19B, ALA251B, ALA289A, ALA316A, ALA322A, ALA328A, ALA349A, ALA354A, ALA382A, ALA384A, ALA391B, ALA422A, ALA422B, ALA466B, ALA87A, ALA95A, ARG161B, ARG162B, ARG166B, ARG170B, ARG184A, ARG184B, ARG193A, ARG208B, ARG215A, ARG216A, ARG217A, ARG217B, ARG218A, ARG218B, ARG226B, ARG253B, ARG257B, ARG262B, ARG321A, ARG326A, ARG385A, ARG393B, ARG40B, ARG446A, ARG451A, ARG459B, ARG468B, ARG484B, ARG488A, ARG488B, ARG496A, ARG496B, ARG507A, ARG88A, ASN203B, ASN209A, ASN260B, ASN327A, ASN389B, ASN390B, ASN454B, ASN485B, ASN86A, ASP107A, ASP111A, ASP145A, ASP155A, ASP202B, ASP241A, ASP281B, ASP358A, ASP378A, ASP417A, ASP427A, ASP427B, ASP431B, ASP435B, ASP464B, ASP474A, ASP500A, ASP500B, ASP82A, ASP93A, CYS348A, GLN115A, GLN152A, GLN153A, GLN16B, GLN173B, GLN256B, GLN323A, GLN394B, GLN405B, GLN418A, GLN441B, GLN81A, GLU113A, GLU116A, GLU128B, GLU14B, GLU183A, GLU186A, GLU187A, GLU187B, GLU197B, GLU198B, GLU212A, GLU212B, GLU214A, GLU221B, GLU234B, GLU318A, GLU319A, GLU352A, GLU357A, GLU444A, GLU448A, GLU487B, GLU501A, GLU501B, GLU504B, GLU77A, GLU78A, GLY114A, GLY189B, GLY195B, GLY213A, GLY227B, GLY233B, GLY250B, GLY291A, GLY293A, GLY355A, GLY386A, GLY398B, GLY401B, GLY421A, GLY421B, GLY447A, GLY460B, GLY46A, GLY492A, GLY492B, GLY49A, GLY51A, GLY91A, HIS15B, HIS230B, HIS423A, HIS423B, HIS429B, HIS463B, ILE127B, ILE185A, ILE18B, ILE191B, ILE206B, ILE222B, ILE239A, ILE283B, ILE31B, ILE346A, ILE38B, ILE397B, ILE425B, ILE430B, ILE433B, ILE437B, ILE445A, ILE467B, ILE472A, ILE489B, ILE490B, ILE497A, ILE497B, ILE508A, ILE83A, ILE84A, LEU167B, LEU171B, LEU211A, LEU220B, LEU223B, LEU225B, LEU249B, LEU254B, LEU285B, LEU324A, LEU325A, LEU383A, LEU439B, LEU43B, LEU505A, LEU54A, LYS172B, LYS224B, LYS232B, LYS280B, LYS294A, LYS404B, LYS457B, LYS465B, LYS502B, LYS52A, LYS85A, MET231B, MET252B, MET420A, MET449A, MET458B, MET471A, PHE151A, PHE165B, PHE199B, PHE278B, PHE279B, PHE315A, PHE419A, PHE456B, PHE483B, PHE486A, PHE486B, PHE76A, PHE90A, PRO110A, PRO112A, PRO190B, PRO236B, PRO248B, PRO351A, PRO37B, PRO494A, PRO494B, PRO80A, SER109A, SER124B, SER146A, SER149A, SER157B, SER158B, SER201B, SER229B, SER258B, SER259B, SER282B, SER320A, SER330A, SER353A, SER379A, SER381A, SER388A, SER416A, SER424B, SER428B, SER450A, SER461B, SER473A, SER482B, SER48A, SER491A, SER491B, SER493A, SER503B, SER89A, THR148A, THR181A, THR182A, THR219B, THR228B, THR238A, THR240A, THR255B, THR287B, THR290A, THR292A, THR295A, THR400B, THR415A, THR426B, THR434B, THR436B, THR47A, THR495A, THR495B, THR498A, THR498B, THR50A, THR53A, THR79A, TRP331A, TRP462B, TYR154A, TYR188B, TYR194A, TYR194B, TYR235B, TYR317A, TYR329A, TYR350A, TYR402B, TYR442A, VAL117A, VAL118A, VAL147A, VAL150A, VAL159B, VAL160B, VAL168B, VAL196B, VAL200B, VAL204B, VAL210A, VAL210B, VAL261B, VAL347A, VAL387A, VAL396B, VAL443A, VAL455B, VAL499A, VAL499B
• A-D: ARG488A, ARG488D
• A-E: ARG488A, ARG488E
• A-F: 1199CB8.7598, 3199CB9.4463, ALA108F, ALA156A, ALA169A, ALA17A, ALA192A, ALA19A, ALA251A, ALA289F, ALA316F, ALA322F, ALA328F, ALA349F, ALA354F, ALA382F, ALA384F, ALA391A, ALA422A, ALA422F, ALA466A, ALA87F, ALA95F, ARG161A, ARG162A, ARG166A, ARG170A, ARG184A, ARG184F, ARG193F, ARG208A, ARG215F, ARG216F, ARG217A, ARG217F, ARG218A, ARG218F, ARG226A, ARG253A, ARG257A, ARG262A, ARG321F, ARG326F, ARG385F, ARG393A, ARG40A, ARG446F, ARG451F, ARG459A, ARG468A, ARG484A, ARG488A, ARG488F, ARG496F, ARG510F, ARG88F, ASN209F, ASN260A, ASN327F, ASN389A, ASN390A, ASN454A, ASN485A, ASN485F, ASN86F, ASP107F, ASP111F, ASP145F, ASP155F, ASP202A, ASP241F, ASP281A, ASP358F, ASP417F, ASP427A, ASP427F, ASP431A, ASP435A, ASP464A, ASP474F, ASP500F, ASP82F, ASP93F, CYS348F, GLN115F, GLN152F, GLN153F, GLN16A, GLN173A, GLN256A, GLN323F, GLN394A, GLN405A, GLN418F, GLN441A, GLN441F, GLN513A, GLN81F, GLU113F, GLU116F, GLU14A, GLU14A5, GLU183F, GLU186F, GLU187A, GLU187F, GLU197A, GLU198A, GLU212F, GLU214F, GLU221A, GLU234A, GLU318F, GLU319F, GLU352F, GLU357F, GLU444F, GLU448F, GLU487A, GLU487F, GLU501F, GLU504A, GLU77F, GLU78F, GLY114F, GLY120A, GLY189A, GLY195A, GLY213F, GLY227A, GLY233A, GLY250A, GLY291F, GLY293F, GLY355F, GLY386F, GLY398A, GLY39A, GLY401A, GLY421A, GLY421F, GLY447F, GLY460A, GLY46F, GLY492A, GLY492F, GLY49F, GLY51F, GLY91F, HIS15A, HIS230A, HIS423A, HIS423F, HIS429A, HIS463A, ILE127A, ILE185F, ILE18A, ILE191A, ILE206A, ILE222A, ILE239F, ILE283A, ILE284A, ILE31A, ILE346F, ILE38A, ILE397A, ILE425A, ILE430A, ILE433A, ILE437A, ILE445F, ILE467A, ILE472F, ILE489A, ILE490A, ILE497A, ILE497F, ILE83F, ILE84F, LEU123A, LEU164A, LEU167A, LEU171A, LEU211F, LEU220A, LEU223A, LEU225A, LEU249A, LEU254A, LEU285A, LEU296F, LEU324F, LEU325F, LEU383F, LEU439A, LEU43A, LEU54F, LYS172A, LYS224A, LYS232A, LYS280A, LYS294F, LYS404A, LYS457A, LYS465A, LYS502A, LYS502F, LYS52F, LYS85F, MET231A, MET252A, MET420F, MET449F, MET458A, MET471F, PHE151F, PHE165A, PHE199A, PHE278A, PHE279A, PHE315F, PHE395A, PHE419F, PHE456A, PHE483A, PHE486A, PHE486F, PHE76F, PHE90F, PRO110F, PRO112F, PRO190A, PRO236A, PRO248A, PRO351F, PRO37A, PRO494A, PRO494F, PRO80F, SER109F, SER124A, SER146F, SER149F, SER157A, SER158A, SER201A, SER229A, SER258A, SER259A, SER282A, SER320F, SER330F, SER353F, SER379F, SER381F, SER416A, SER416F, SER424A, SER428A, SER450F, SER461A, SER473F, SER482A, SER48F, SER491A, SER491F, SER493F, SER89F, THR148F, THR181F, THR182F, THR219A, THR228A, THR238F, THR240F, THR255A, THR287A, THR290F, THR292F, THR295F, THR400A, THR415F, THR426A, THR434A, THR436A, THR47F, THR495A, THR495F, THR498F, THR50F, THR53F, THR75F, THR79F, TRP331F, TRP462A, TYR154F, TYR188A, TYR194A, TYR194F, TYR235A, TYR317F, TYR329F, TYR350F, TYR402A, TYR442F, VAL117F, VAL118F, VAL147F, VAL150F, VAL159A, VAL160A, VAL168A, VAL196A, VAL200A, VAL204A, VAL210A, VAL261A, VAL347F, VAL387F, VAL396A, VAL443F, VAL455A
• B-C: ALA108B, ALA156C, ALA169C, ALA17C, ALA192C, ALA19C, ALA251C, ALA289B, ALA316B, ALA322B, ALA328B, ALA349B, ALA354B, ALA382B, ALA384B, ALA391C, ALA422B, ALA422C, ALA466C, ALA87B, ALA95B, ARG161C, ARG162C, ARG166C, ARG170C, ARG184B, ARG184C, ARG193B, ARG193C, ARG208C, ARG215B, ARG216B, ARG217B, ARG217C, ARG218B, ARG226C, ARG253C, ARG257C, ARG262C, ARG321B, ARG326B, ARG385B, ARG393C, ARG40C, ARG446B, ARG451B, ARG459C, ARG468C, ARG484C, ARG488B, ARG488C, ARG496B, ARG88B, ASN203C, ASN209B, ASN260C, ASN327B, ASN389C, ASN390C, ASN454C, ASN485C, ASN86B, ASP107B, ASP111B, ASP145B, ASP155B, ASP202C, ASP241B, ASP281C, ASP358B, ASP378B, ASP417B, ASP427B, ASP427C, ASP431C, ASP435C, ASP464C, ASP474B, ASP500B, ASP82B, ASP93B, CYS348B, GLN115B, GLN152B, GLN153B, GLN16C, GLN173C, GLN256C, GLN323B, GLN394C, GLN405C, GLN418B, GLN441C, GLN81B, GLU113B, GLU116B, GLU14C, GLU183B, GLU186B, GLU187B, GLU187C, GLU197C, GLU198C, GLU212B, GLU212C, GLU214B, GLU221C, GLU234C, GLU318B, GLU319B, GLU352B, GLU357B, GLU444B, GLU448B, GLU487B, GLU487C, GLU501C, GLU77B, GLU78B, GLY114B, GLY189C, GLY195C, GLY213B, GLY227C, GLY233C, GLY250C, GLY291B, GLY293B, GLY355B, GLY386B, GLY398C, GLY39C, GLY401C, GLY421B, GLY421C, GLY447B, GLY460C, GLY46B, GLY492B, GLY492C, GLY49B, GLY51B, GLY91B, HIS15C, HIS230C, HIS423B, HIS423C, HIS429C, HIS463C, ILE127C, ILE185B, ILE18C, ILE191C, ILE206C, ILE222C, ILE239B, ILE283C, ILE31C, ILE346B, ILE38C, ILE397C, ILE425C, ILE430C, ILE433C, ILE437C, ILE445B, ILE467C, ILE472B, ILE489C, ILE490C, ILE497B, ILE497C, ILE83B, ILE84B, LEU123C, LEU167C, LEU171C, LEU211B, LEU220C, LEU223C, LEU225C, LEU249C, LEU254C, LEU285C, LEU324B, LEU325B, LEU383B, LEU439C, LEU43C, LEU54B, LYS172C, LYS224C, LYS232C, LYS280C, LYS294B, LYS404C, LYS457C, LYS465C, LYS480B, LYS52B, LYS85B, MET231C, MET252C, MET420B, MET449B, MET458C, MET471B, PHE151B, PHE165C, PHE199C, PHE247C, PHE278C, PHE279C, PHE395C, PHE419B, PHE456C, PHE483C, PHE486B, PHE486C, PHE76B, PHE90B, PRO110B, PRO112B, PRO190C, PRO236C, PRO248C, PRO351B, PRO37C, PRO494B, PRO494C, SER109B, SER124C, SER146B, SER149B, SER157C, SER158C, SER201C, SER229C, SER258C, SER259C, SER282C, SER320B, SER330B, SER353B, SER379B, SER381B, SER388B, SER416B, SER424C, SER428C, SER450B, SER461C, SER473B, SER482C, SER48B, SER491B, SER491C, SER493B, SER89B, THR148B, THR181B, THR182B, THR219C, THR228C, THR238B, THR240B, THR255C, THR287C, THR290B, THR292B, THR295B, THR400C, THR415B, THR426C, THR432C, THR434C, THR436C, THR47B, THR495B, THR495C, THR498B, THR498C, THR50B, THR53B, THR79B, TRP331B, TRP462C, TYR154B, TYR188C, TYR194B, TYR194C, TYR235C, TYR317B, TYR329B, TYR350B, TYR402C, TYR442B, VAL117B, VAL147B, VAL150B, VAL159C, VAL160C, VAL168C, VAL196C, VAL200C, VAL204C, VAL210B, VAL210C, VAL261C, VAL347B, VAL387B, VAL396C, VAL443B, VAL455C, VAL499B, VAL499C
• B-D: ARG488B, ARG488D
• B-E: ARG488B, ARG488E
• B-F: ARG488B, ARG488F
• C-D: ALA156D, ALA169D, ALA17D, ALA192D, ALA19D, ALA251D, ALA289C, ALA316C, ALA322C, ALA328C, ALA349C, ALA354C, ALA382C, ALA384C, ALA391D, ALA422C, ALA422D, ALA466D, ALA87C, ALA95C, ARG161D, ARG162D, ARG166D, ARG170D, ARG184C, ARG184D, ARG193C, ARG193D, ARG208D, ARG215C, ARG216C, ARG217C, ARG217D, ARG218C, ARG218D, ARG226D, ARG253D, ARG257D, ARG262D, ARG321C, ARG326C, ARG385C, ARG393D, ARG40D, ARG446C, ARG451C, ARG459D, ARG468D, ARG484D, ARG488C, ARG488D, ARG496C, ARG496D, ARG88C, ASN203D, ASN209C, ASN260D, ASN327C, ASN389D, ASN390D, ASN454D, ASN485D, ASN86C, ASP111C, ASP145C, ASP155C, ASP202D, ASP241C, ASP281D, ASP358C, ASP378C, ASP417C, ASP427C, ASP427D, ASP431D, ASP435D, ASP464D, ASP474C, ASP82C, ASP93C, CYS348C, GLN115C, GLN152C, GLN153C, GLN16D, GLN173D, GLN256D, GLN323C, GLN394D, GLN405D, GLN418C, GLN441D, GLN81C, GLU113C, GLU116C, GLU14D, GLU183C, GLU186C, GLU187C, GLU187D, GLU197D, GLU198D, GLU212C, GLU212D, GLU214C, GLU221D, GLU234D, GLU318C, GLU319C, GLU352C, GLU357C, GLU444C, GLU448C, GLU487C, GLU487D, GLU77C, GLU78C, GLY114C, GLY189D, GLY195D, GLY213C, GLY227D, GLY233D, GLY250D, GLY291C, GLY293C, GLY355C, GLY386C, GLY398D, GLY39D, GLY401D, GLY421C, GLY421D, GLY447C, GLY460D, GLY46C, GLY492C, GLY492D, GLY49C, GLY51C, GLY91C, HIS15D, HIS230D, HIS423C, HIS423D, HIS429D, HIS463D, ILE127D, ILE185C, ILE18D, ILE191D, ILE206D, ILE222D, ILE239C, ILE283D, ILE31D, ILE346C, ILE38D, ILE397D, ILE425D, ILE430D, ILE433D, ILE437D, ILE445C, ILE467D, ILE472C, ILE489D, ILE490D, ILE497C, ILE497D, ILE83C, ILE84C, LEU167D, LEU211C, LEU220D, LEU223D, LEU225D, LEU249D, LEU254D, LEU285D, LEU324C, LEU325C, LEU383C, LEU439D, LEU43D, LEU54C, LYS172D, LYS224D, LYS232D, LYS280D, LYS294C, LYS404D, LYS457D, LYS465D, LYS52C, LYS85C, LYS96C, MET231D, MET252D, MET420C, MET449C, MET458D, MET471C, PHE151C, PHE165D, PHE199D, PHE278D, PHE279D, PHE315C, PHE419C, PHE456D, PHE470C, PHE483D, PHE486C, PHE486D, PHE76C, PHE90C, PRO110C, PRO112C, PRO190D, PRO236D, PRO248D, PRO351C, PRO37D, PRO494C, PRO494D, SER109C, SER124D, SER146C, SER149C, SER157D, SER158D, SER201D, SER229D, SER258D, SER259D, SER282D, SER320C, SER330C, SER353C, SER379C, SER381C, SER388C, SER416C, SER424D, SER428D, SER450C, SER461D, SER473C, SER482D, SER48C, SER491C, SER491D, SER493C, SER89C, THR148C, THR182C, THR219D, THR228D, THR238C, THR240C, THR255D, THR287D, THR290C, THR292C, THR295C, THR400D, THR415C, THR426D, THR432D, THR434D, THR436D, THR47C, THR495C, THR495D, THR50C, THR53C, THR79C, TRP331C, TRP462D, TYR154C, TYR188D, TYR194C, TYR194D, TYR235D, TYR317C, TYR329C, TYR350C, TYR402D, TYR442C, VAL118C, VAL147C, VAL150C, VAL159D, VAL160D, VAL168D, VAL196D, VAL200D, VAL204D, VAL210C, VAL210D, VAL261D, VAL347C, VAL387C, VAL396D, VAL455D
• C-E: ARG488C, ARG488E, THR495C
• D-E: ALA156E, ALA169E, ALA17E, ALA192E, ALA19E, ALA251E, ALA289D, ALA316D, ALA322D, ALA328D, ALA349D, ALA354D, ALA382D, ALA384D, ALA391E, ALA422D, ALA422E, ALA466E, ALA87D, ALA95D, ARG161E, ARG162E, ARG166E, ARG170E, ARG184D, ARG184E, ARG193D, ARG208E, ARG215D, ARG216D, ARG217D, ARG217E, ARG218D, ARG218E, ARG226E, ARG253E, ARG257E, ARG262E, ARG321D, ARG326D, ARG385D, ARG393E, ARG40E, ARG446D, ARG451D, ARG459E, ARG468E, ARG484E, ARG488D, ARG488E, ARG496D, ARG88D, ASN203E, ASN209D, ASN260E, ASN327D, ASN389E, ASN390E, ASN454E, ASN485E, ASN86D, ASP107D, ASP111D, ASP145D, ASP155D, ASP202E, ASP241D, ASP281E, ASP358D, ASP378D, ASP417D, ASP427D, ASP427E, ASP431E, ASP435E, ASP464E, ASP474D, ASP481E, ASP500E, ASP82D, ASP93D, CYS348D, GLN115D, GLN152D, GLN153D, GLN16E, GLN173E, GLN256E, GLN323D, GLN394E, GLN405E, GLN418D, GLN441E, GLN81D, GLU113D, GLU116D, GLU14E, GLU183D, GLU186D, GLU187D, GLU187E, GLU197E, GLU198E, GLU212D, GLU212E, GLU214D, GLU221E, GLU234E, GLU318D, GLU319D, GLU352D, GLU357D, GLU444D, GLU448D, GLU487D, GLU487E, GLU77D, GLU78D, GLY114D, GLY189E, GLY195E, GLY213D, GLY227E, GLY233E, GLY250E, GLY291D, GLY293D, GLY355D, GLY386D, GLY398E, GLY39E, GLY401E, GLY421D, GLY421E, GLY447D, GLY460E, GLY46D, GLY492D, GLY492E, GLY49D, GLY51D, GLY91D, HIS15E, HIS230E, HIS359D, HIS423D, HIS423E, HIS429E, HIS463E, ILE127E, ILE185D, ILE18E, ILE191E, ILE206E, ILE222E, ILE239D, ILE283E, ILE31E, ILE346D, ILE38E, ILE397E, ILE425E, ILE430E, ILE433E, ILE437E, ILE445D, ILE467E, ILE472D, ILE489E, ILE490E, ILE497D, ILE497E, ILE83D, ILE84D, LEU123E, LEU167E, LEU171E, LEU211D, LEU220E, LEU223E, LEU225E, LEU249E, LEU254E, LEU285E, LEU324D, LEU325D, LEU383D, LEU439E, LEU54D, LYS172E, LYS224E, LYS232E, LYS280E, LYS294D, LYS404E, LYS457E, LYS465E, LYS52D, LYS85D, LYS96D, MET231E, MET252E, MET420D, MET449D, MET458E, MET471D, PHE151D, PHE165E, PHE199E, PHE247E, PHE278E, PHE279E, PHE419D, PHE456E, PHE470D, PHE483E, PHE486D, PHE486E, PHE76D, PHE90D, PRO110D, PRO112D, PRO190E, PRO236E, PRO248E, PRO351D, PRO37E, PRO494D, PRO494E, PRO80D, SER109D, SER124E, SER146D, SER149D, SER157E, SER158E, SER201E, SER229E, SER258E, SER259E, SER282E, SER320D, SER330D, SER353D, SER379D, SER381D, SER416D, SER416E, SER424E, SER450D, SER461E, SER473D, SER482E, SER48D, SER491D, SER491E, SER493D, SER89D, THR148D, THR182D, THR219E, THR228E, THR238D, THR240D, THR255E, THR287E, THR290D, THR292D, THR295D, THR400E, THR415D, THR426E, THR434E, THR436E, THR47D, THR495D, THR495E, THR498D, THR498E, THR50D, THR53D, THR79D, TRP331D, TRP462E, TRP92D, TYR154D, TYR188E, TYR194D, TYR194E, TYR235E, TYR317D, TYR329D, TYR350D, TYR402E, TYR442D, VAL147D, VAL150D, VAL159E, VAL160E, VAL168E, VAL196E, VAL200E, VAL204E, VAL210E, VAL261E, VAL347D, VAL387D, VAL396E, VAL443D, VAL455E, VAL499E
• E-F: ALA156F, ALA169F, ALA17F, ALA192F, ALA19F, ALA251F, ALA289E, ALA316E, ALA322E, ALA328E, ALA349E, ALA354E, ALA382E, ALA384E, ALA391F, ALA422E, ALA422F, ALA466F, ALA87E, ARG161F, ARG162F, ARG166F, ARG170F, ARG184E, ARG184F, ARG193E, ARG193F, ARG208F, ARG215E, ARG216E, ARG217E, ARG217F, ARG218E, ARG218F, ARG226F, ARG253F, ARG257F, ARG262F, ARG321E, ARG326E, ARG385E, ARG393F, ARG40F, ARG446E, ARG451E, ARG459F, ARG468F, ARG484F, ARG488E, ARG488F, ARG496E, ARG88E, ASN203F, ASN209E, ASN260F, ASN327E, ASN389F, ASN390F, ASN414E, ASN454F, ASN485F, ASN86E, ASP107E, ASP111E, ASP145E, ASP155E, ASP202F, ASP241E, ASP281F, ASP358E, ASP378E, ASP417E, ASP427E, ASP427F, ASP431F, ASP435F, ASP464F, ASP474E, ASP82E, CYS348E, GLN115E, GLN152E, GLN153E, GLN16F, GLN173F, GLN256F, GLN323E, GLN394F, GLN405F, GLN418E, GLN441F, GLN81E, GLU113E, GLU116E, GLU128F, GLU183E, GLU186E, GLU187E, GLU187F, GLU197F, GLU198F, GLU212E, GLU212F, GLU214E, GLU221F, GLU234F, GLU318E, GLU319E, GLU352E, GLU357E, GLU444E, GLU448E, GLU487E, GLU487F, GLU501E, GLU77E, GLU78E, GLY114E, GLY189F, GLY195F, GLY213E, GLY227F, GLY233F, GLY250F, GLY288E, GLY291E, GLY293E, GLY355E, GLY386E, GLY398F, GLY39F, GLY401F, GLY421E, GLY421F, GLY447E, GLY460F, GLY46E, GLY492E, GLY492F, GLY49E, GLY51E, GLY91E, HIS15F, HIS230F, HIS242E, HIS423E, HIS423F, HIS429F, HIS463F, ILE127F, ILE185E, ILE18F, ILE191F, ILE206F, ILE222F, ILE239E, ILE283F, ILE31F, ILE346E, ILE38F, ILE397F, ILE425F, ILE430F, ILE433F, ILE437F, ILE445E, ILE467F, ILE472E, ILE489F, ILE490F, ILE497E, ILE497F, ILE83E, ILE84E, LEU164F, LEU167F, LEU171F, LEU211E, LEU220F, LEU223F, LEU225F, LEU249F, LEU254F, LEU285F, LEU324E, LEU325E, LEU383E, LEU439F, LEU43F, LEU54E, LYS172F, LYS224F, LYS232F, LYS280F, LYS294E, LYS404F, LYS457F, LYS465F, LYS52E, LYS85E, MET231F, MET252F, MET420E, MET449E, MET458F, MET471E, PHE121F, PHE151E, PHE165F, PHE199F, PHE247F, PHE278F, PHE279F, PHE419E, PHE456F, PHE470E, PHE483F, PHE486E, PHE486F, PHE76E, PHE90E, PRO110E, PRO112E, PRO190F, PRO236F, PRO248F, PRO351E, PRO37F, PRO494E, PRO494F, SER109E, SER124F, SER146E, SER149E, SER157F, SER158F, SER201F, SER229F, SER258F, SER259F, SER282F, SER320E, SER330E, SER353E, SER379E, SER381E, SER388E, SER416E, SER424F, SER428F, SER450E, SER461F, SER473E, SER482F, SER48E, SER491E, SER491F, SER493E, SER89E, THR148E, THR182E, THR219F, THR228F, THR238E, THR240E, THR255F, THR287F, THR290E, THR292E, THR295E, THR400F, THR413E, THR415E, THR426F, THR432F, THR434F, THR436F, THR47E, THR495E, THR495F, THR50E, THR53E, THR79E, TRP331E, TRP462F, TRP92E, TYR154E, TYR188F, TYR194E, TYR194F, TYR235F, TYR317E, TYR329E, TYR350E, TYR402F, TYR442E, VAL117E, VAL118E, VAL147E, VAL150E, VAL159F, VAL160F, VAL168F, VAL196F, VAL200F, VAL204F, VAL210F, VAL261F, VAL347E, VAL387E, VAL396F, VAL443E, VAL455F, VAL499F