3JQO

crystal structure of the outer membrane complex of a type iv secretion system

• Total interactions analyzed: 861
• Total true interactions: 143
• Strongest Interaction:
  • Chains: o-p
  • Int. Res.: 75
  • Norm. En. per Res.: -5.0716
• Hub Node: B(12)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-134.4054	-55.7212	-366.244	-556.3706	119	17	9	14169	8	32	17
A-C	0.0	0.0	-0.1337	-0.1337	7	0	0	43	0	0	1
A-D	-156.1971	-129.1013	-564.694	-849.9924	215	36	22	22374	13	45	40
A-E	-49.0456	-5.9416	-253.352	-308.3392	80	16	1	9544	2	25	26
A-F	-4.2939	-17.3922	-77.5419	-99.228	30	3	0	2302	0	11	2
A-G	-7.1131	-63.3543	-81.7572	-152.2246	38	4	3	3129	5	9	4
A-J	0.0	0.0	-36.047	-36.047	24	2	0	1649	0	0	1
A-h	0.0	0.0	-38.6166	-38.6166	24	2	0	1708	0	1	1
A-k	-11.1107	-66.3602	-80.6845	-158.1554	42	4	3	3202	5	9	4
A-n	-138.5036	-139.4868	-540.571	-818.5614	211	30	22	21705	14	45	40
A-o	0.0	0.0	-1.9699	-1.9699	6	0	0	153	0	0	0
B-C	-48.8931	-35.0258	-287.285	-371.204	82	11	6	10079	4	22	17
B-D	0.0	0.0	-1.8922	-1.8922	6	0	0	137	0	0	0
B-E	-27.9029	-3.1616	-120.13	-151.1945	52	7	4	4448	0	14	11
B-n	-43.4612	-5.4843	-241.548	-290.4935	80	11	1	9304	2	25	25
B-o	-28.1148	-2.8651	-102.078	-133.0578	52	3	4	3962	0	13	12
C-k	0.0	0.0	-0.2457	-0.2457	2	0	0	50	0	0	0
C-n	0.0	-17.67	-99.7972	-117.4672	36	13	0	2918	0	11	2
D-E	-141.3975	-45.3409	-367.893	-554.6314	118	20	9	14226	8	32	17
D-F	0.0	0.0	-0.1237	-0.1237	5	0	0	38	0	0	1
D-G	-178.8842	-145.4814	-544.332	-868.6975	214	38	21	22195	14	45	40
D-H	-55.9871	-10.567	-256.326	-322.8801	82	17	1	9649	2	25	27
D-I	0.0	-17.5618	-74.6802	-92.242	30	7	0	2275	0	11	2
D-J	-9.9165	-65.3161	-83.1439	-158.3765	38	4	3	3146	5	9	4
D-L	0.0	0.0	-0.0389	-0.0389	4	0	0	19	0	0	0
D-M	0.0	0.0	-35.001	-35.001	24	3	0	1698	0	0	1
D-k	0.0	0.0	-36.3661	-36.3661	24	2	0	1648	0	1	2
D-n	-9.0001	-65.2684	-81.0733	-155.3418	40	4	3	3086	5	9	4
E-F	-58.7029	-36.082	-281.634	-376.4188	81	13	6	10329	4	22	17
E-G	0.0	0.0	-1.9312	-1.9312	6	0	0	142	0	0	0
E-H	-16.9564	-3.221	-116.318	-136.4954	52	4	4	4349	0	14	11
G-H	-136.9102	-55.1372	-365.322	-557.3694	120	22	9	14186	8	32	17
G-I	0.0	0.0	-0.1396	-0.1396	5	0	0	40	0	0	1
G-J	-180.134	-139.4662	-567.365	-886.9652	211	35	21	22376	13	45	41
G-K	-65.2898	-6.3974	-242.688	-314.3752	81	18	1	9474	2	25	25
G-L	0.0	-17.7449	-76.0224	-93.7673	38	6	0	2486	0	11	2
G-M	-6.9033	-63.2505	-83.0186	-153.1724	43	4	3	3150	5	9	4
G-P	0.0	0.0	-34.8727	-34.8727	24	5	0	1648	0	0	1
G-n	0.0	0.0	-34.8644	-34.8644	23	1	0	1626	0	0	1
H-I	-50.4825	-35.0336	-276.83	-362.3461	78	13	6	10144	4	22	17
H-J	0.0	0.0	-1.8296	-1.8296	6	0	0	143	0	0	0
H-K	-18.695	-3.0806	-111.305	-133.0807	52	5	4	4261	0	14	11
J-K	-147.726	-57.3373	-367.229	-572.2923	123	16	9	14182	7	32	17
J-L	0.0	0.0	-0.1398	-0.1398	7	0	0	44	0	0	1
J-M	-174.2856	-119.3832	-562.405	-856.0738	220	37	22	22916	13	45	41
J-N	-58.0882	-5.8572	-252.665	-316.6104	82	21	1	9619	2	25	25
J-O	0.0	-17.1946	-71.5598	-88.7544	29	8	0	2136	0	11	2
J-P	-5.9952	-63.2195	-81.8903	-151.1051	38	3	3	3119	5	9	4
J-S	0.0	0.0	-37.6166	-37.6166	24	2	0	1659	0	0	1
K-L	-45.5173	-35.1451	-283.305	-363.9674	81	10	6	10276	4	22	17
K-M	0.0	0.0	-1.8602	-1.8602	5	0	0	134	0	0	0
K-N	-25.6889	-3.1951	-120.469	-149.3529	52	7	4	4454	0	14	11
M-N	-154.7322	-55.2991	-367.416	-577.4473	121	20	9	14196	7	32	17
M-O	0.0	0.0	-0.1343	-0.1343	7	0	0	40	0	0	1
M-P	-183.6993	-147.9869	-563.053	-894.7392	221	43	22	23221	14	45	41
M-Q	-58.426	-7.9766	-247.978	-314.3806	80	15	1	9528	2	25	25
M-R	0.0	-17.1399	-70.0973	-87.2372	28	7	0	2162	0	11	2
M-S	-7.9655	-63.9118	-85.7871	-157.6645	41	4	3	3176	5	9	4
M-U	0.0	0.0	-2.3587	-2.3587	5	0	0	155	0	0	0
M-V	-3.3873	0.0	-38.2525	-41.6398	24	3	0	1727	0	0	2
N-O	-51.9402	-35.9539	-280.647	-368.541	79	10	6	10205	4	22	17
N-P	0.0	0.0	-1.9917	-1.9917	5	0	0	139	0	0	0
N-Q	-25.3463	-3.0551	-120.759	-149.1604	52	6	4	4442	0	14	11
P-Q	-146.737	-46.4666	-368.326	-561.5296	119	20	9	14194	8	32	17
P-R	0.0	0.0	-0.1351	-0.1351	5	0	0	40	0	0	1
P-S	-172.4066	-144.7531	-580.236	-897.3957	220	34	22	22898	14	46	40
P-T	-47.8253	-5.9009	-252.528	-306.2543	81	19	1	9524	2	25	25
P-U	-23.3998	-17.1956	-98.8348	-139.4302	33	14	0	3062	0	11	2
P-V	-8.0157	-66.4156	-82.3477	-156.7789	40	5	3	3193	5	9	4
P-Y	-6.0417	0.0	-33.7767	-39.8184	24	2	0	1682	0	1	1
Q-R	-40.9251	-36.7567	-277.65	-355.3317	74	12	6	9764	4	22	17
Q-S	0.0	0.0	-2.0499	-2.0499	6	0	0	141	0	0	0
Q-T	-30.4161	-3.1978	-117.298	-150.9119	52	7	4	4423	0	14	11
S-T	-135.1157	-46.6125	-354.815	-536.5432	118	19	9	14062	7	32	17
S-U	0.0	0.0	-0.1188	-0.1188	7	0	0	41	0	0	1
S-V	-164.9968	-138.8755	-552.589	-856.4613	216	38	22	22618	14	45	41
S-W	-49.3062	-3.4358	-251.197	-303.939	80	17	1	9478	2	25	25
S-X	0.0	-17.4154	-70.2778	-87.6932	29	9	0	2134	0	11	2
S-Y	-9.1408	-62.441	-84.1177	-155.6995	39	4	3	3121	5	9	4
S-b	-7.6982	0.0	-39.3067	-47.0048	24	3	0	1709	0	0	1
T-U	-43.8627	-31.2173	-287.414	-362.494	80	12	6	10220	4	22	16
T-V	0.0	0.0	-1.9831	-1.9831	6	0	0	145	0	0	0
T-W	-32.3002	-3.1426	-110.576	-146.0188	52	4	4	4189	0	14	11
V-W	-125.2152	-56.6033	-362.563	-544.3814	119	17	9	14170	7	32	17
V-X	0.0	0.0	-0.1286	-0.1286	5	0	0	39	0	0	1
V-Y	-167.9611	-144.8639	-565.829	-878.654	217	31	22	22545	16	45	40
V-Z	-51.9385	-9.9398	-249.719	-311.5972	80	18	1	9524	2	25	25
V-a	0.0	-17.3185	-72.4103	-89.7288	29	8	0	2156	0	11	2
V-b	-8.7099	-67.2835	-78.7356	-154.729	39	3	3	3123	5	9	4
V-e	-17.3627	0.0	-37.0938	-54.4565	23	2	0	1689	0	0	1
W-X	-57.9526	-33.4139	-289.48	-380.8465	78	11	6	10336	4	22	17
W-Y	0.0	0.0	-1.8799	-1.8799	6	0	0	138	0	0	0
W-Z	-24.1412	-3.1296	-116.873	-144.1438	52	5	4	4371	0	14	11
Y-Z	-126.4359	-45.237	-366.153	-537.8259	120	18	9	14142	8	32	17
Y-a	0.0	0.0	-0.131	-0.131	5	0	0	37	0	0	1
Y-b	-170.9614	-143.3193	-559.441	-873.7217	217	32	22	22570	15	45	41
Y-c	-55.5548	-5.5437	-253.634	-314.7324	79	10	1	9528	2	25	26
Y-d	0.0	-17.4564	-72.9296	-90.386	29	9	0	2174	0	11	2
Y-e	-7.119	-21.6873	-80.1814	-108.9877	40	3	3	3095	5	9	4
Y-h	-9.8011	0.0	-35.5258	-45.3269	23	3	0	1629	0	0	1
Z-a	-55.4497	-35.5011	-281.202	-372.1528	82	13	6	10228	4	22	17
Z-b	0.0	0.0	-1.8027	-1.8027	6	0	0	142	0	0	0
Z-c	-22.2525	-3.1801	-109.987	-135.4195	52	8	4	4316	0	14	11
b-c	-129.3315	-51.8906	-362.453	-543.6751	118	20	9	14160	8	32	17
b-d	0.0	0.0	-0.134	-0.134	5	0	0	40	0	0	1
b-e	-154.4503	-152.5443	-562.19	-869.1846	216	32	22	22686	15	45	41
b-f	-64.9908	-7.7917	-249.195	-321.9775	80	16	1	9615	2	25	26
b-g	0.0	-17.9192	-76.6989	-94.6181	30	8	0	2328	0	11	2
b-h	-6.9879	-63.219	-77.0327	-147.2396	37	4	3	3095	5	9	4
b-k	-7.703	0.0	-37.1377	-44.8407	24	3	0	1658	0	0	1
c-d	-57.7475	-33.3011	-286.745	-377.7936	80	10	6	10251	4	22	17
c-e	0.0	0.0	-1.6671	-1.6671	6	0	0	131	0	0	0
c-f	-42.5455	-3.1343	-114.449	-160.1288	52	8	4	4365	0	14	11
e-f	-133.6793	-58.0413	-366.49	-558.2106	120	17	9	14155	8	32	17
e-g	0.0	0.0	-0.1509	-0.1509	5	0	0	44	0	0	1
e-h	-150.2092	-119.3912	-550.997	-820.5974	219	26	22	22153	13	45	41
e-i	-50.2941	-6.2738	-253.575	-310.1429	81	16	1	9525	2	25	25
e-j	-9.0068	-17.5563	-72.7036	-99.2666	28	1	0	2219	0	11	2
e-k	-7.596	-63.7369	-80.7926	-152.1255	38	4	3	3120	5	9	4
e-n	0.0	0.0	-36.311	-36.311	24	1	0	1643	0	0	1
f-g	-57.2016	-33.582	-290.847	-381.6306	80	13	6	10293	4	22	17
f-h	0.0	0.0	-1.972	-1.972	6	0	0	136	0	0	0
f-i	-38.4432	-3.1208	-115.668	-157.232	52	8	4	4322	0	14	11
h-i	-136.6365	-53.0757	-359.084	-548.7962	120	18	9	14114	8	32	17
h-j	0.0	0.0	-0.1383	-0.1383	5	0	0	41	0	0	1
h-k	-160.0458	-149.3245	-557.119	-866.4893	214	31	22	22344	14	45	41
h-l	-57.9402	-7.3397	-245.699	-310.9789	80	13	1	9607	2	25	25
h-m	0.0	-17.7187	-73.912	-91.6307	28	7	0	2323	0	11	2
h-n	-7.6218	-62.7726	-82.591	-152.9854	41	5	3	3182	5	11	4
i-j	-45.861	-36.2425	-282.916	-365.0195	77	14	6	10175	4	22	17
i-k	0.0	0.0	-2.0319	-2.0319	6	0	0	141	0	0	0
i-l	-30.8316	-3.1417	-119.322	-153.2952	52	9	4	4387	0	14	11
k-l	-128.1658	-53.4133	-362.08	-543.6591	121	18	9	14185	7	32	17
k-m	0.0	0.0	-0.1346	-0.1346	7	0	0	39	0	0	1
k-n	-157.7721	-155.7905	-574.546	-888.1087	220	36	22	22642	15	46	43
k-o	-47.2794	-6.343	-252.573	-306.1954	81	14	1	9447	2	25	26
k-p	0.0	-17.276	-66.1915	-83.4675	27	8	0	2120	0	11	2
l-m	-47.431	-36.1034	-282.761	-366.2954	81	11	6	10192	4	22	17
l-n	0.0	0.0	-2.3896	-2.3896	5	0	0	140	0	0	0
l-o	-33.5429	-3.2137	-119.281	-156.0376	52	6	4	4436	0	14	11
n-o	-127.1034	-49.0449	-363.067	-539.2153	118	18	9	14133	7	32	17
n-p	0.0	0.0	-0.1239	-0.1239	5	0	0	39	0	0	1
o-p	-52.1965	-34.5405	-293.632	-380.3689	75	13	6	10045	4	22	17

Interface residues

• A-B: ALA175B, ALA197A, ALA225B, ALA236A, ALA275B, ALA277B, ALA281B, ALA366A, ALA384A, ARG205B, ARG208B, ARG241A, ARG254B, ARG256B, ARG286B, ARG287B, ASN198A, ASN233B, ASN273A, ASN288A, ASN386A, ASP232A, ASP237A, ASP244A, ASP276A, ASP284B, ASP361A, ASP365A, ASP385A, CYS211A, GLN169B, GLN173B, GLN231A, GLN275A, GLN289B, GLN362A, GLU229B, GLU245B, GLU247B, GLY206A, GLY212A, GLY227B, GLY238A, GLY272B, GLY277A, GLY279B, GLY291A, GLY364A, GLY379A, HIS235B, ILE167B, ILE209A, ILE223B, ILE243A, ILE279A, ILE290B, ILE295A, ILE369A, LEU171B, LEU201A, LEU231B, LEU239A, LEU242A, LEU290A, LEU383A, LYS164B, LYS165B, LYS170B, LYS172B, LYS207A, LYS228B, LYS245A, PHE176B, PHE206B, PHE269B, PHE370A, PHE377A, PRO199A, PRO204A, PRO210A, PRO232B, PRO271B, PRO283B, PRO296A, SER200A, SER224B, SER226B, SER230A, SER234B, SER235A, SER282B, SER289A, SER292A, SER368A, SER378A, THR168B, THR174B, THR230B, THR248B, THR278A, THR278B, THR280B, THR287A, THR382A, TYR221B, TYR234A, TYR381A, VAL203A, VAL233A, VAL236B, VAL237B, VAL240A, VAL249B, VAL276B, VAL285B, VAL288B, VAL367A, VAL371A, VAL380A
• A-C: ARG263A, GLN42C, HIS19C, LEU239A, LEU290A, PRO21C, PRO22C
• A-D: ALA178A, ALA178D, ALA180A, ALA180D, ALA186A, ALA186D, ALA190D, ALA193D, ALA197D, ALA236D, ALA262D, ALA285D, ALA293D, ALA301A, ALA301D, ALA310A, ALA310D, ALA322A, ALA345A, ALA345D, ALA348A, ALA348D, ALA372A, ALA372D, ARG187A, ARG187D, ARG192D, ARG228A, ARG263D, ARG270A, ARG272A, ARG306A, ARG306D, ARG308A, ARG308D, ARG350A, ARG350D, ARG373A, ARG373D, ASN182A, ASN182D, ASN198A, ASN273A, ASN281A, ASN288D, ASP218A, ASP237D, ASP250A, ASP259D, ASP274A, ASP276A, ASP283A, ASP283D, ASP300A, ASP300D, ASP318A, ASP318D, ASP361A, ASP374A, ASP374D, ASP376A, CYS227A, GLN224A, GLN252A, GLN261D, GLN275A, GLN362A, GLN363A, GLU171D, GLU174D, GLU216A, GLU269A, GLU305A, GLU347A, GLU347D, GLY175D, GLY194D, GLY206D, GLY214A, GLY223A, GLY238D, GLY251A, GLY256D, GLY260D, GLY277A, GLY286D, GLY291D, GLY294D, GLY309A, GLY364A, GLY379A, HIS302A, HIS302D, ILE243A, ILE253A, ILE257D, ILE271A, ILE279A, ILE282A, ILE295D, ILE311A, ILE311D, ILE313A, ILE313D, ILE355A, LEU179A, LEU179D, LEU183A, LEU183D, LEU188A, LEU188D, LEU201A, LEU217A, LEU239D, LEU242A, LEU290D, LEU307A, LEU307D, LEU315D, LEU320A, LEU320D, LEU344A, LEU344D, LEU349A, LEU349D, LEU359A, LEU359D, LEU375A, LEU375D, LYS181A, LYS181D, LYS189A, LYS189D, LYS205A, LYS205D, LYS207D, LYS258D, PHE265D, PHE316A, PHE316D, PHE370A, PHE370D, PHE377A, PRO185A, PRO185D, PRO199D, PRO204A, PRO204D, PRO222A, PRO296D, PRO356A, PRO356D, PRO357A, PRO357D, SER173D, SER176D, SER177A, SER177D, SER191A, SER191D, SER226A, SER235D, SER284A, SER284D, SER289D, SER292D, SER314A, SER314D, SER317A, SER317D, SER346A, SER346D, SER351A, SER351D, SER354A, SER368D, SER378A, THR172D, THR184A, THR184D, THR202A, THR202D, THR215A, THR219A, THR220A, THR278A, THR287D, THR319A, THR319D, THR321A, THR321D, THR358A, THR358D, TRP248A, TRP268A, TRP304A, TRP304D, TYR234D, TYR352A, TYR352D, TYR360A, TYR381A, VAL195D, VAL203A, VAL203D, VAL221A, VAL225A, VAL249A, VAL264D, VAL266D, VAL280A, VAL299D, VAL371A, VAL371D, VAL380A
• A-E: ALA213E, ALA215E, ALA366A, ARG228A, ARG241A, ARG241E, ARG254E, ARG256E, ARG272A, ASN214E, ASN233E, ASN240E, ASN242E, ASN273A, ASP232A, ASP244A, ASP259E, ASP274A, ASP276A, ASP361A, ASP365A, CYS211A, CYS227A, GLN169E, GLN173E, GLN219E, GLN231A, GLN275A, GLN362A, GLN363A, GLU216A, GLU216E, GLU229E, GLU239E, GLU245E, GLU247E, GLY212A, GLY214A, GLY238E, GLY246A, GLY258E, GLY364A, HIS235E, ILE195E, ILE223E, ILE243A, ILE243E, ILE244E, ILE255E, LEU217E, LEU231E, LEU257E, LYS245A, LYS260E, PHE209E, PHE211E, PRO210A, PRO212E, PRO218E, PRO232E, SER226A, SER230A, SER234E, SER247A, SER289A, THR213A, THR215A, THR230E, TRP248A, TYR221E, TYR234A, VAL220E, VAL225A, VAL229A, VAL233A, VAL236E, VAL237E, VAL246E, VAL261E, VAL367A
• A-F: ALA301A, ASP218A, ASP300A, ASP361A, ASP365A, GLN275A, GLN298A, GLN362A, GLN363A, GLN42F, GLU216A, GLU24F, GLY18F, GLY297A, GLY364A, HIS19F, HIS302A, ILE257A, LEU217A, LEU359A, LYS20F, PRO21F, PRO22F, PRO23F, PRO357A, THR219A, THR220A, THR358A, TYR360A, VAL299A
• A-G: ALA178G, ALA180G, ALA186G, ALA190G, ALA285A, ALA293A, ALA372A, ARG187G, ARG270A, ARG373A, ASN182G, ASN281A, ASP250A, ASP283A, GLN224A, GLN252A, GLU269A, GLY251A, GLY286A, ILE282A, ILE313A, ILE369A, LEU179G, LEU183G, LEU188G, LEU267A, LEU349G, LYS181G, PHE265A, PHE370A, PRO185G, SER284A, THR184G, THR254A, TRP268A, VAL266A, VAL280A, VAL371A
• A-J: ALA178J, ALA180J, ASN182J, GLN224A, GLN252A, GLU174J, GLU269A, GLY175J, GLY223A, GLY251A, GLY255A, ILE253A, LEU179J, LEU183J, LEU267A, PHE265A, PRO222A, SER173J, SER176J, SER177J, THR172J, THR254A, VAL221A, VAL225A
• A-h: ALA178A, ALA180A, ASN182A, GLN224h, GLN252h, GLU174A, GLU269h, GLY175A, GLY223h, GLY251h, GLY255h, ILE253h, LEU179A, LEU183A, LEU267h, PHE265h, PRO222h, SER173A, SER176A, SER177A, THR172A, THR254h, VAL221h, VAL225h
• A-k: ALA178A, ALA180A, ALA186A, ALA186k, ALA190A, ALA285k, ALA293k, ALA372k, ARG187A, ARG270k, ARG373k, ASN182A, ASN281k, ASP250k, ASP283k, GLN224k, GLN252k, GLN343k, GLU171A, GLU269k, GLY251k, GLY286k, ILE282k, ILE313k, ILE369k, LEU179A, LEU183A, LEU188A, LEU267k, LEU349A, LYS181A, PHE265k, PHE370k, PRO185A, SER284k, SER346A, THR184A, THR254k, TRP268k, VAL266k, VAL280k, VAL371k
• A-n: 5341CB4.4282, ALA178A, ALA178n, ALA180A, ALA180n, ALA186A, ALA186n, ALA190A, ALA193A, ALA197A, ALA236A, ALA262A, ALA285A, ALA293A, ALA301A, ALA301n, ALA310A, ALA310n, ALA345A, ALA345n, ALA348A, ALA348n, ALA372A, ALA372n, ARG187A, ARG187n, ARG192A, ARG228n, ARG263A, ARG270n, ARG272n, ARG306A, ARG306n, ARG308A, ARG308n, ARG350A, ARG350n, ARG373A, ARG373n, ASN182n, ASN198n, ASN273n, ASN281n, ASN288A, ASP218n, ASP237A, ASP250n, ASP259A, ASP274n, ASP276n, ASP283A, ASP283n, ASP300A, ASP300n, ASP318A, ASP318n, ASP361n, ASP374A, ASP374n, ASP376n, CYS227n, GLN224n, GLN252n, GLN261A, GLN275n, GLN362n, GLN363n, GLU171A, GLU171A5, GLU174A, GLU216n, GLU269n, GLU305n, GLU347A, GLU347n, GLY175A, GLY194A, GLY206A, GLY214n, GLY223n, GLY238A, GLY251n, GLY256A, GLY260A, GLY277n, GLY286A, GLY291A, GLY294A, GLY309n, GLY342n, GLY364n, GLY379n, HIS302A, HIS302n, ILE243n, ILE253n, ILE257A, ILE271n, ILE279n, ILE282n, ILE295A, ILE311A, ILE311n, ILE313n, ILE355n, ILE369A, LEU179A, LEU179n, LEU183A, LEU183n, LEU188A, LEU188n, LEU201n, LEU217n, LEU239A, LEU242n, LEU290A, LEU307A, LEU307n, LEU315A, LEU315n, LEU344A, LEU344n, LEU349A, LEU349n, LEU359A, LEU359n, LEU375A, LEU375n, LYS181A, LYS181n, LYS189A, LYS189n, LYS205A, LYS205n, LYS207A, LYS258A, PHE265A, PHE316n, PHE370A, PHE370n, PHE377n, PRO185A, PRO185n, PRO199A, PRO204A, PRO204n, PRO222n, PRO296A, PRO356A, PRO356n, PRO357A, PRO357n, SER173A, SER176A, SER177A, SER177n, SER191A, SER191n, SER226n, SER235A, SER284A, SER284n, SER289A, SER292A, SER314A, SER314n, SER317A, SER317n, SER346A, SER346n, SER351A, SER351n, SER354n, SER368A, SER378n, THR172A, THR184A, THR184n, THR202A, THR202n, THR215n, THR219n, THR220n, THR278n, THR287A, THR319n, THR358A, THR358n, TRP248n, TRP268n, TRP304A, TRP304n, TYR234A, TYR352A, TYR352n, TYR360n, TYR381n, VAL195A, VAL203A, VAL203n, VAL221n, VAL225n, VAL249n, VAL264A, VAL266A, VAL280n, VAL299A, VAL371A, VAL371n, VAL380n
• A-o: ARG192A, GLN289o, GLY194A, ILE290o, PRO199A, VAL195A
• B-C: ALA175B, ALA177B, ARG193B, ARG208B, ARG254B, ARG256B, ARG265B, ASN181B, ASN240B, ASN242B, ASN266B, ASN267B, ASN29C, ASN34C, ASP202B, ASP259B, ASP26C, ASP40C, GLN169B, GLN173B, GLN183B, GLN189B, GLN196B, GLN42C, GLU188B, GLU191B, GLU210B, GLU229B, GLU239B, GLU245B, GLU24C, GLU252B, GLY178B, GLY238B, GLY258B, GLY263B, HIS199B, ILE223B, ILE243B, ILE255B, ILE37C, LEU171B, LEU257B, LYS170B, LYS172B, LYS180B, LYS20C, LYS251B, LYS260B, LYS35C, PHE176B, PHE209B, PRO190B, PRO197B, PRO21C, PRO22C, PRO23C, PRO25C, PRO32C, PRO38C, SER187B, SER28C, THR174B, THR30C, THR36C, THR41C, TRP201B, TRP253B, TRP27C, TYR182B, TYR184B, TYR221B, VAL185B, VAL198B, VAL200B, VAL237B, VAL261B, VAL262B, VAL264B, VAL31C, VAL33C, VAL39C
• B-D: ARG192D, GLN289B, GLY194D, ILE290B, PRO199D, VAL195D
• B-E: ALA213E, ALA215E, ALA225B, ALA250B, ALA270B, ALA275B, ALA277B, ARG193E, ARG205B, ARG241E, ARG256E, ARG273B, ARG287B, ASN203B, ASN214E, ASN240E, ASN242E, ASP259E, GLN196E, GLU191E, GLU216E, GLU239E, GLY227B, GLY238E, GLY258E, GLY272B, GLY274B, GLY279B, ILE195E, ILE223B, LEU217E, LEU257E, LYS228B, LYS251B, LYS260E, PHE206B, PHE211E, PHE269B, PRO212E, PRO218E, PRO271B, SER194E, SER224B, SER226B, THR230B, THR248B, THR278B, THR280B, TYR204B, VAL198E, VAL249B, VAL276B
• B-n: ALA213B, ALA215B, ALA366n, ARG228n, ARG241B, ARG241n, ARG254B, ARG256B, ARG272n, ASN214B, ASN233B, ASN240B, ASN242B, ASN273n, ASP232n, ASP244n, ASP259B, ASP274n, ASP276n, ASP361n, ASP365n, CYS211n, CYS227n, GLN169B, GLN173B, GLN219B, GLN231n, GLN275n, GLN362n, GLN363n, GLU216B, GLU216n, GLU229B, GLU239B, GLU245B, GLU247B, GLY212n, GLY214n, GLY238B, GLY246n, GLY258B, GLY364n, HIS235B, ILE195B, ILE223B, ILE243B, ILE243n, ILE244B, ILE255B, LEU217B, LEU231B, LEU257B, LYS245n, LYS260B, PHE209B, PHE211B, PRO210n, PRO212B, PRO218B, PRO232B, SER226n, SER230n, SER234B, SER247n, SER289n, THR213n, THR215n, THR230B, TRP248n, TYR221B, TYR234n, VAL220B, VAL225n, VAL229n, VAL233n, VAL236B, VAL237B, VAL246B, VAL261B, VAL367n
• B-o: ALA213B, ALA215B, ALA225o, ALA250o, ALA270o, ALA275o, ALA277o, ARG193B, ARG205o, ARG241B, ARG256B, ARG273o, ARG287o, ASN203o, ASN214B, ASN240B, ASN242B, ASP259B, GLN196B, GLU191B, GLU216B, GLU239B, GLY227o, GLY238B, GLY258B, GLY272o, GLY274o, GLY279o, ILE195B, ILE223o, LEU217B, LEU257B, LYS228o, LYS251o, LYS260B, PHE206o, PHE211B, PHE269o, PRO212B, PRO218B, PRO271o, SER194B, SER224o, SER226o, THR230o, THR248o, THR278o, THR280o, TYR204o, VAL198B, VAL249o, VAL276o
• C-k: ARG308k, SER17C
• C-n: ALA301n, ARG306n, ASP218n, ASP300n, ASP361n, ASP365n, GLN275n, GLN298n, GLN362n, GLN363n, GLN42C, GLU216n, GLU24C, GLU305n, GLY18C, GLY297n, GLY364n, HIS19C, HIS302n, ILE257n, LEU217n, LEU307n, LEU359n, LYS20C, PRO21C, PRO22C, PRO23C, PRO357n, SER17C, THR219n, THR220n, THR358n, TRP304n, TYR352n, TYR360n, VAL299n
• D-E: ALA175E, ALA197D, ALA225E, ALA236D, ALA275E, ALA277E, ALA281E, ALA366D, ALA384D, ARG205E, ARG208E, ARG241D, ARG254E, ARG256E, ARG286E, ARG287E, ASN198D, ASN233E, ASN273D, ASN288D, ASN386D, ASP232D, ASP237D, ASP244D, ASP276D, ASP284E, ASP361D, ASP365D, ASP385D, CYS211D, GLN169E, GLN173E, GLN231D, GLN275D, GLN289E, GLN362D, GLU229E, GLU245E, GLU247E, GLY206D, GLY212D, GLY227E, GLY238D, GLY272E, GLY277D, GLY279E, GLY291D, GLY364D, GLY379D, HIS235E, ILE167E, ILE209D, ILE223E, ILE243D, ILE279D, ILE290E, ILE295D, LEU171E, LEU201D, LEU231E, LEU239D, LEU242D, LEU290D, LEU383D, LYS164E, LYS165E, LYS170E, LYS172E, LYS207D, LYS228E, LYS245D, PHE176E, PHE206E, PHE269E, PHE370D, PHE377D, PRO199D, PRO204D, PRO210D, PRO232E, PRO271E, PRO283E, PRO296D, SER200D, SER224E, SER226E, SER230D, SER234E, SER235D, SER282E, SER289D, SER292D, SER368D, SER378D, THR168E, THR174E, THR230E, THR248E, THR278D, THR278E, THR280E, THR287D, THR382D, TYR221E, TYR234D, TYR381D, VAL203D, VAL233D, VAL236E, VAL237E, VAL240D, VAL249E, VAL276E, VAL285E, VAL288E, VAL367D, VAL371D, VAL380D
• D-F: ARG263D, HIS19F, LEU290D, PRO21F, PRO22F
• D-G: ALA178D, ALA178G, ALA180D, ALA180G, ALA186D, ALA186G, ALA190G, ALA193G, ALA197G, ALA236G, ALA262G, ALA285D, ALA285G, ALA293G, ALA301D, ALA301G, ALA310D, ALA310G, ALA322D, ALA345D, ALA345G, ALA348D, ALA348G, ALA372D, ALA372G, ARG187D, ARG187G, ARG192G, ARG228D, ARG263G, ARG270D, ARG272D, ARG306D, ARG306G, ARG308D, ARG308G, ARG350D, ARG350G, ARG373D, ARG373G, ASN182D, ASN198D, ASN273D, ASN281D, ASN288G, ASP218D, ASP237G, ASP250D, ASP259G, ASP274D, ASP276D, ASP283D, ASP283G, ASP300D, ASP300G, ASP318D, ASP318G, ASP361D, ASP374D, ASP374G, ASP376D, CYS227D, GLN224D, GLN252D, GLN261G, GLN275D, GLN343G, GLN362D, GLN363D, GLU171G, GLU174G, GLU216D, GLU269D, GLU305D, GLU347D, GLU347G, GLY175G, GLY194G, GLY206G, GLY214D, GLY223D, GLY238G, GLY251D, GLY256G, GLY260G, GLY277D, GLY286G, GLY291G, GLY294G, GLY309D, GLY364D, GLY379D, HIS302D, HIS302G, ILE243D, ILE253D, ILE257G, ILE271D, ILE279D, ILE282D, ILE295G, ILE311D, ILE311G, ILE313D, ILE313G, ILE355D, LEU179D, LEU179G, LEU183D, LEU183G, LEU188D, LEU188G, LEU201D, LEU217D, LEU239G, LEU242D, LEU290G, LEU307D, LEU307G, LEU315D, LEU315G, LEU320D, LEU344D, LEU344G, LEU349D, LEU349G, LEU359D, LEU359G, LEU375D, LEU375G, LYS181D, LYS181G, LYS189D, LYS189G, LYS205D, LYS205G, LYS207G, LYS258G, PHE265G, PHE316D, PHE316G, PHE370D, PHE370G, PHE377D, PRO185D, PRO185G, PRO199G, PRO204G, PRO222D, PRO296G, PRO356D, PRO356G, PRO357D, PRO357G, SER173G, SER176G, SER177D, SER177G, SER191D, SER191G, SER226D, SER235G, SER284D, SER284G, SER289G, SER292G, SER314D, SER314G, SER317D, SER317G, SER346D, SER346G, SER351D, SER351G, SER354D, SER368G, SER378D, THR172G, THR184D, THR184G, THR202D, THR202G, THR215D, THR219D, THR220D, THR278D, THR287G, THR319D, THR319G, THR321D, THR358D, THR358G, TRP248D, TRP268D, TRP304D, TRP304G, TYR234G, TYR352D, TYR352G, TYR360D, TYR381D, VAL195G, VAL203D, VAL203G, VAL221D, VAL225D, VAL249D, VAL264G, VAL266G, VAL280D, VAL299G, VAL371D, VAL371G, VAL380D
• D-H: ALA213H, ALA215H, ALA366D, ARG228D, ARG241D, ARG241H, ARG254H, ARG256H, ARG272D, ASN214H, ASN233H, ASN240H, ASN242H, ASN273D, ASP232D, ASP244D, ASP259H, ASP274D, ASP276D, ASP361D, ASP365D, CYS211D, CYS227D, GLN169H, GLN173H, GLN219H, GLN231D, GLN275D, GLN362D, GLN363D, GLU216D, GLU216H, GLU229H, GLU239H, GLU245H, GLU247H, GLY212D, GLY214D, GLY238H, GLY246D, GLY258H, GLY364D, HIS235H, ILE195H, ILE223H, ILE243D, ILE243H, ILE244H, ILE255H, LEU217H, LEU231H, LEU257H, LYS245D, LYS260H, PHE209H, PHE211H, PRO210D, PRO212H, PRO218H, PRO232H, SER226D, SER230D, SER234H, SER247D, SER289D, THR213D, THR215D, THR230H, TRP248D, TYR221H, TYR234D, TYR360D, TYR381D, VAL220H, VAL225D, VAL229D, VAL233D, VAL236H, VAL237H, VAL246H, VAL261H, VAL367D
• D-I: ALA301D, ASP218D, ASP300D, ASP361D, ASP365D, GLN275D, GLN298D, GLN362D, GLN363D, GLN42I, GLU216D, GLU24I, GLY18I, GLY297D, GLY364D, HIS19I, HIS302D, ILE257D, LEU217D, LEU359D, LYS20I, PRO21I, PRO22I, PRO23I, PRO357D, THR219D, THR220D, THR358D, TYR360D, VAL299D
• D-J: ALA178J, ALA180J, ALA186J, ALA190J, ALA285D, ALA293D, ALA372D, ARG187J, ARG270D, ARG373D, ASN182J, ASN281D, ASP250D, ASP283D, GLN224D, GLN252D, GLU269D, GLY251D, GLY286D, ILE282D, ILE313D, ILE369D, LEU179J, LEU183J, LEU188J, LEU267D, LEU349J, LYS181J, PHE265D, PHE370D, PRO185J, SER284D, THR184J, THR254D, TRP268D, VAL266D, VAL280D, VAL371D
• D-L: ARG308D, CYS15L, SER16L, TRP304D
• D-M: ALA178M, ALA180M, ASN182M, GLN224D, GLN252D, GLU174M, GLU269D, GLY175M, GLY223D, GLY251D, GLY255D, ILE253D, LEU179M, LEU183M, LEU267D, PHE265D, PRO222D, SER173M, SER176M, SER177M, THR172M, THR254D, VAL221D, VAL225D
• D-k: ALA178D, ALA180D, ASN182D, GLN224k, GLN252k, GLU174D, GLU269k, GLY175D, GLY223k, GLY251k, GLY255k, ILE253k, LEU179D, LEU183D, LEU267k, PHE265k, PRO222k, SER173D, SER176D, SER177D, THR172D, THR254k, VAL221k, VAL225k
• D-n: ALA178D, ALA180D, ALA186D, ALA186n, ALA190D, ALA285n, ALA293n, ALA372n, ARG187D, ARG270n, ARG373n, ASN182D, ASN281n, ASP250n, ASP283n, GLN224n, GLN252n, GLU171D, GLU269n, GLY251n, GLY286n, ILE282n, ILE313n, ILE369n, LEU179D, LEU183D, LEU188D, LEU267n, LEU349D, LYS181D, PHE265n, PHE370n, PRO185D, SER284n, THR184D, THR254n, TRP268n, VAL266n, VAL280n, VAL371n
• E-F: ALA175E, ALA177E, ARG193E, ARG208E, ARG254E, ARG256E, ARG265E, ASN181E, ASN240E, ASN242E, ASN266E, ASN267E, ASN29F, ASN34F, ASP202E, ASP259E, ASP26F, ASP40F, GLN173E, GLN183E, GLN189E, GLN196E, GLN42F, GLU188E, GLU191E, GLU210E, GLU229E, GLU239E, GLU245E, GLU24F, GLU252E, GLY178E, GLY238E, GLY258E, GLY263E, HIS199E, ILE223E, ILE243E, ILE255E, ILE37F, LEU171E, LEU257E, LYS170E, LYS172E, LYS180E, LYS20F, LYS251E, LYS260E, LYS35F, PHE176E, PHE209E, PRO190E, PRO197E, PRO21F, PRO22F, PRO23F, PRO25F, PRO32F, PRO38F, SER187E, SER28F, THR174E, THR30F, THR36F, THR41F, TRP201E, TRP253E, TRP27F, TYR182E, TYR184E, TYR221E, VAL185E, VAL198E, VAL200E, VAL237E, VAL261E, VAL262E, VAL264E, VAL31F, VAL33F, VAL39F
• E-G: ARG192G, GLN289E, GLY194G, ILE290E, PRO199G, VAL195G
• E-H: ALA213H, ALA215H, ALA225E, ALA250E, ALA270E, ALA275E, ALA277E, ARG193H, ARG205E, ARG241H, ARG256H, ARG273E, ARG287E, ASN203E, ASN214H, ASN240H, ASN242H, ASP259H, GLN196H, GLU191H, GLU216H, GLU239H, GLY227E, GLY238H, GLY258H, GLY272E, GLY274E, GLY279E, ILE195H, ILE223E, LEU217H, LEU257H, LYS228E, LYS251E, LYS260H, PHE206E, PHE211H, PHE269E, PRO212H, PRO218H, PRO271E, SER194H, SER224E, SER226E, THR230E, THR248E, THR278E, THR280E, TYR204E, VAL198H, VAL249E, VAL276E
• G-H: ALA175H, ALA197G, ALA225H, ALA236G, ALA275H, ALA277H, ALA281H, ALA366G, ALA384G, ARG205H, ARG208H, ARG241G, ARG254H, ARG256H, ARG286H, ARG287H, ASN198G, ASN233H, ASN273G, ASN288G, ASN386G, ASP232G, ASP237G, ASP244G, ASP276G, ASP284H, ASP361G, ASP365G, ASP385G, CYS211G, GLN169H, GLN173H, GLN231G, GLN275G, GLN289H, GLN362G, GLU229H, GLU245H, GLU247H, GLY206G, GLY212G, GLY227H, GLY238G, GLY277G, GLY279H, GLY291G, GLY364G, GLY379G, HIS235H, ILE167H, ILE209G, ILE223H, ILE243G, ILE279G, ILE290H, ILE295G, ILE369G, LEU171H, LEU201G, LEU231H, LEU239G, LEU242G, LEU290G, LEU383G, LYS164H, LYS165H, LYS170H, LYS172H, LYS207G, LYS228H, LYS245G, PHE176H, PHE206H, PHE269H, PHE370G, PHE377G, PRO199G, PRO204G, PRO210G, PRO232H, PRO271H, PRO283H, PRO296G, SER200G, SER224H, SER226H, SER230G, SER234H, SER235G, SER247G, SER282H, SER289G, SER292G, SER368G, SER378G, THR168H, THR174H, THR230H, THR248H, THR278G, THR278H, THR280H, THR287G, THR382G, TYR221H, TYR234G, TYR381G, VAL203G, VAL220H, VAL233G, VAL236H, VAL237H, VAL240G, VAL249H, VAL276H, VAL285H, VAL288H, VAL367G, VAL371G, VAL380G
• G-I: ARG263G, HIS19I, LEU290G, PRO21I, PRO22I
• G-J: ALA178G, ALA178J, ALA180G, ALA180J, ALA186G, ALA186J, ALA190J, ALA193J, ALA197J, ALA236J, ALA262J, ALA285G, ALA285J, ALA293J, ALA301G, ALA301J, ALA310G, ALA310J, ALA345G, ALA345J, ALA348G, ALA348J, ALA372G, ALA372J, ARG187G, ARG187J, ARG192J, ARG228G, ARG263J, ARG270G, ARG272G, ARG306G, ARG306J, ARG308G, ARG308J, ARG350G, ARG350J, ARG373G, ARG373J, ASN182G, ASN198G, ASN273G, ASN281G, ASN288J, ASP218G, ASP237J, ASP250G, ASP259J, ASP274G, ASP276G, ASP283G, ASP283J, ASP300G, ASP300J, ASP318G, ASP318J, ASP361G, ASP374G, ASP374J, ASP376G, CYS227G, GLN224G, GLN252G, GLN261J, GLN275G, GLN343G, GLN343J, GLN362G, GLN363G, GLU171J, GLU174J, GLU216G, GLU269G, GLU305G, GLU347G, GLU347J, GLY175J, GLY194J, GLY206J, GLY214G, GLY223G, GLY238J, GLY251G, GLY256J, GLY260J, GLY277G, GLY286J, GLY291J, GLY294J, GLY309G, GLY342J, GLY364G, GLY379G, HIS302G, HIS302J, ILE243G, ILE253G, ILE257J, ILE271G, ILE279G, ILE282G, ILE295J, ILE311G, ILE311J, ILE313G, ILE355G, LEU179G, LEU179J, LEU183G, LEU183J, LEU188G, LEU188J, LEU201G, LEU217G, LEU239J, LEU242G, LEU290J, LEU307G, LEU307J, LEU315G, LEU315J, LEU344G, LEU344J, LEU349G, LEU349J, LEU359G, LEU359J, LEU375G, LEU375J, LYS181G, LYS181J, LYS189G, LYS189J, LYS205G, LYS205J, LYS207J, LYS258J, PHE265J, PHE316G, PHE370G, PHE370J, PHE377G, PRO185G, PRO185J, PRO199J, PRO204G, PRO204J, PRO222G, PRO296J, PRO356G, PRO356J, PRO357G, PRO357J, SER173J, SER176J, SER177G, SER177J, SER191G, SER191J, SER226G, SER235J, SER284G, SER284J, SER289J, SER292J, SER314G, SER314J, SER317G, SER317J, SER346G, SER346J, SER351G, SER351J, SER354G, SER368J, SER378G, THR172J, THR184G, THR184J, THR202G, THR202J, THR213G, THR215G, THR219G, THR220G, THR278G, THR287J, THR319G, THR358G, TRP248G, TRP268G, TRP304G, TRP304J, TYR234J, TYR352G, TYR352J, TYR360G, TYR381G, VAL195J, VAL203G, VAL203J, VAL221G, VAL225G, VAL249G, VAL264J, VAL266J, VAL280G, VAL299J, VAL371G, VAL371J, VAL380G
• G-K: ALA213K, ALA215K, ALA366G, ARG228G, ARG241G, ARG241K, ARG254K, ARG256K, ARG272G, ASN214K, ASN233K, ASN240K, ASN242K, ASN273G, ASP232G, ASP244G, ASP259K, ASP274G, ASP276G, ASP361G, ASP365G, CYS211G, CYS227G, GLN169K, GLN173K, GLN219K, GLN231G, GLN275G, GLN362G, GLN363G, GLU216G, GLU216K, GLU229K, GLU239K, GLU245K, GLU247K, GLY212G, GLY214G, GLY238K, GLY246G, GLY258K, GLY364G, HIS235K, ILE195K, ILE223K, ILE243G, ILE243K, ILE244K, ILE255K, LEU217K, LEU231K, LEU257K, LYS245G, LYS260K, PHE209K, PHE211K, PRO210G, PRO212K, PRO218K, PRO232K, SER226G, SER230G, SER234K, SER247G, SER289G, THR213G, THR215G, THR230K, TRP248G, TYR221K, TYR234G, TYR381G, VAL220K, VAL225G, VAL229G, VAL233G, VAL236K, VAL237K, VAL246K, VAL261K, VAL367G
• G-L: ALA301G, ARG306G, ASP218G, ASP300G, ASP361G, ASP365G, CYS15L, GLN275G, GLN298G, GLN362G, GLN363G, GLN42L, GLU216G, GLU24L, GLU305G, GLY18L, GLY297G, GLY364G, HIS19L, HIS302G, ILE257G, ILE311G, LEU217G, LEU307G, LEU359G, LYS20L, PRO21L, PRO22L, PRO23L, PRO357G, SER16L, SER17L, THR219G, THR220G, THR358G, TRP304G, TYR360G, VAL299G
• G-M: ALA178M, ALA180M, ALA186G, ALA186M, ALA190M, ALA285G, ALA293G, ALA372G, ARG187M, ARG270G, ARG373G, ASN182M, ASN281G, ASP250G, ASP283G, GLN224G, GLN252G, GLN343G, GLU171M, GLU269G, GLY251G, GLY286G, GLY342M, ILE282G, ILE313G, ILE369G, LEU179M, LEU183M, LEU188M, LEU267G, LEU349M, LYS181M, PHE265G, PHE370G, PRO185M, SER284G, SER346M, THR184M, THR254G, TRP268G, VAL266G, VAL280G, VAL371G
• G-P: ALA178P, ALA180P, ASN182P, GLN224G, GLN252G, GLU174P, GLU269G, GLY175P, GLY223G, GLY251G, GLY255G, ILE253G, LEU179P, LEU183P, LEU267G, PHE265G, PRO222G, SER173P, SER176P, SER177P, THR172P, THR254G, VAL221G, VAL225G
• G-n: ALA178G, ALA180G, ASN182G, GLN224n, GLN252n, GLU174G, GLU269n, GLY175G, GLY223n, GLY251n, GLY255n, ILE253n, LEU179G, LEU183G, LEU267n, PHE265n, PRO222n, SER173G, SER176G, SER177G, THR254n, VAL221n, VAL225n
• H-I: ALA175H, ALA177H, ARG193H, ARG208H, ARG254H, ARG256H, ARG265H, ASN181H, ASN266H, ASN267H, ASN29I, ASN34I, ASP202H, ASP259H, ASP26I, ASP40I, GLN173H, GLN183H, GLN189H, GLN196H, GLN42I, GLU188H, GLU191H, GLU210H, GLU229H, GLU239H, GLU245H, GLU24I, GLU252H, GLY178H, GLY238H, GLY258H, GLY263H, HIS199H, ILE223H, ILE243H, ILE255H, ILE37I, LEU171H, LEU257H, LYS170H, LYS172H, LYS180H, LYS20I, LYS251H, LYS260H, LYS35I, PHE176H, PHE209H, PRO190H, PRO197H, PRO21I, PRO22I, PRO23I, PRO25I, PRO32I, PRO38I, SER187H, SER28I, THR174H, THR30I, THR36I, THR41I, TRP201H, TRP253H, TRP27I, TYR182H, TYR184H, VAL185H, VAL198H, VAL200H, VAL237H, VAL261H, VAL262H, VAL264H, VAL31I, VAL33I, VAL39I
• H-J: ARG192J, GLN289H, GLY194J, ILE290H, PRO199J, VAL195J
• H-K: ALA213K, ALA215K, ALA225H, ALA250H, ALA270H, ALA275H, ALA277H, ARG193K, ARG205H, ARG241K, ARG256K, ARG273H, ARG287H, ASN203H, ASN214K, ASN240K, ASN242K, ASP259K, GLN196K, GLU191K, GLU216K, GLU239K, GLY227H, GLY238K, GLY258K, GLY272H, GLY274H, GLY279H, ILE195K, ILE223H, LEU217K, LEU257K, LYS228H, LYS251H, LYS260K, PHE206H, PHE211K, PHE269H, PRO212K, PRO218K, PRO271H, SER194K, SER224H, SER226H, THR230H, THR248H, THR278H, THR280H, TYR204H, VAL198K, VAL249H, VAL276H
• J-K: ALA175K, ALA197J, ALA225K, ALA236J, ALA250K, ALA275K, ALA277K, ALA281K, ALA366J, ALA384J, ARG205K, ARG208K, ARG241J, ARG254K, ARG256K, ARG286K, ARG287K, ASN198J, ASN203K, ASN233K, ASN273J, ASN288J, ASN386J, ASP232J, ASP237J, ASP244J, ASP276J, ASP284K, ASP361J, ASP365J, ASP385J, CYS211J, GLN169K, GLN173K, GLN231J, GLN275J, GLN289K, GLN362J, GLU229K, GLU245K, GLU247K, GLY206J, GLY212J, GLY227K, GLY238J, GLY272K, GLY277J, GLY279K, GLY291J, GLY364J, GLY379J, HIS235K, ILE167K, ILE209J, ILE223K, ILE243J, ILE279J, ILE290K, ILE295J, ILE369J, LEU171K, LEU201J, LEU231K, LEU239J, LEU242J, LEU290J, LEU383J, LYS164K, LYS165K, LYS170K, LYS172K, LYS207J, LYS228K, LYS245J, PHE176K, PHE206K, PHE269K, PHE370J, PHE377J, PRO199J, PRO204J, PRO210J, PRO232K, PRO271K, PRO283K, PRO296J, SER200J, SER224K, SER226K, SER230J, SER234K, SER235J, SER282K, SER289J, SER292J, SER368J, SER378J, THR168K, THR174K, THR213J, THR230K, THR248K, THR278J, THR278K, THR280K, THR287J, THR382J, TYR221K, TYR234J, TYR381J, VAL203J, VAL220K, VAL233J, VAL236K, VAL237K, VAL240J, VAL249K, VAL276K, VAL285K, VAL288K, VAL367J, VAL371J, VAL380J
• J-L: ARG263J, GLN42L, HIS19L, LEU239J, LEU290J, PRO21L, PRO22L
• J-M: ALA178J, ALA178M, ALA180J, ALA180M, ALA186J, ALA186M, ALA190M, ALA193M, ALA197M, ALA236M, ALA262M, ALA285J, ALA285M, ALA293M, ALA301J, ALA301M, ALA310J, ALA310M, ALA322J, ALA345J, ALA345M, ALA348J, ALA348M, ALA372J, ALA372M, ARG187J, ARG187M, ARG192M, ARG228J, ARG263M, ARG270J, ARG272J, ARG306J, ARG306M, ARG308J, ARG308M, ARG350J, ARG350M, ARG373J, ARG373M, ASN182J, ASN198J, ASN273J, ASN281J, ASN288M, ASP218J, ASP237M, ASP250J, ASP259M, ASP274J, ASP276J, ASP283J, ASP283M, ASP300J, ASP300M, ASP318J, ASP318M, ASP361J, ASP374J, ASP374M, ASP376J, CYS227J, GLN224J, GLN252J, GLN261M, GLN275J, GLN343J, GLN343M, GLN362J, GLN363J, GLU171M, GLU174M, GLU216J, GLU269J, GLU305J, GLU347J, GLU347M, GLY175M, GLY194M, GLY206M, GLY214J, GLY223J, GLY238M, GLY251J, GLY256M, GLY260M, GLY277J, GLY286M, GLY291M, GLY294M, GLY309J, GLY342J, GLY342M, GLY364J, GLY379J, HIS302J, HIS302M, ILE243J, ILE253J, ILE257M, ILE271J, ILE279J, ILE282J, ILE295M, ILE311J, ILE311M, ILE313J, ILE313M, ILE355J, LEU179J, LEU179M, LEU183J, LEU183M, LEU188J, LEU188M, LEU201J, LEU217J, LEU239M, LEU242J, LEU290M, LEU307J, LEU307M, LEU315J, LEU315M, LEU320J, LEU344J, LEU344M, LEU349J, LEU349M, LEU359J, LEU359M, LEU375J, LEU375M, LYS181J, LYS181M, LYS189J, LYS189M, LYS205J, LYS205M, LYS207M, LYS258M, PHE265M, PHE316J, PHE316M, PHE370J, PHE370M, PHE377J, PRO185J, PRO185M, PRO199M, PRO204J, PRO204M, PRO222J, PRO296M, PRO356J, PRO356M, PRO357J, PRO357M, SER173M, SER176M, SER177J, SER177M, SER191J, SER191M, SER226J, SER235M, SER284J, SER284M, SER289M, SER292M, SER314J, SER314M, SER317J, SER317M, SER346J, SER346M, SER351J, SER351M, SER354J, SER368M, SER378J, THR172M, THR184J, THR184M, THR202J, THR202M, THR213J, THR215J, THR219J, THR220J, THR278J, THR287M, THR319J, THR319M, THR321J, THR321M, THR358J, THR358M, TRP248J, TRP268J, TRP304J, TRP304M, TYR234M, TYR352J, TYR352M, TYR360J, TYR381J, VAL195M, VAL203J, VAL203M, VAL221J, VAL225J, VAL249J, VAL264M, VAL266M, VAL280J, VAL299M, VAL371J, VAL371M, VAL380J
• J-N: ALA213N, ALA215N, ALA366J, ARG228J, ARG241J, ARG241N, ARG254N, ARG256N, ARG272J, ASN214N, ASN233N, ASN240N, ASN242N, ASN273J, ASP232J, ASP244J, ASP259N, ASP274J, ASP276J, ASP361J, ASP365J, CYS211J, CYS227J, GLN169N, GLN173N, GLN219N, GLN231J, GLN275J, GLN362J, GLN363J, GLU216J, GLU216N, GLU229N, GLU239N, GLU245N, GLU247N, GLY212J, GLY214J, GLY238N, GLY246J, GLY258N, GLY364J, HIS235N, ILE195N, ILE223N, ILE243J, ILE243N, ILE244N, ILE255N, LEU217N, LEU231N, LEU257N, LYS245J, LYS260N, PHE209N, PHE211N, PRO210J, PRO212N, PRO218N, PRO232N, SER226J, SER230J, SER234N, SER247J, SER289J, THR213J, THR215J, THR230N, TRP248J, TYR221N, TYR234J, TYR360J, TYR381J, VAL220N, VAL225J, VAL229J, VAL233J, VAL236N, VAL237N, VAL246N, VAL261N, VAL367J
• J-O: ALA301J, ASP218J, ASP300J, ASP361J, ASP365J, GLN275J, GLN298J, GLN362J, GLN363J, GLN42O, GLU216J, GLU24O, GLY297J, GLY364J, HIS19O, HIS302J, ILE257J, LEU217J, LEU359J, LYS20O, PRO21O, PRO22O, PRO23O, PRO357J, THR219J, THR220J, THR358J, TYR360J, VAL299J
• J-P: ALA178P, ALA180P, ALA186P, ALA190P, ALA285J, ALA293J, ALA372J, ARG187P, ARG270J, ARG373J, ASN182P, ASN281J, ASP250J, ASP283J, GLN224J, GLN252J, GLU269J, GLY251J, GLY286J, ILE282J, ILE313J, ILE369J, LEU179P, LEU183P, LEU188P, LEU267J, LEU349P, LYS181P, PHE265J, PHE370J, PRO185P, SER284J, THR184P, THR254J, TRP268J, VAL266J, VAL280J, VAL371J
• J-S: ALA178S, ALA180S, ASN182S, GLN224J, GLN252J, GLU174S, GLU269J, GLY175S, GLY223J, GLY251J, GLY255J, ILE253J, LEU179S, LEU183S, LEU267J, PHE265J, PRO222J, SER173S, SER176S, SER177S, THR172S, THR254J, VAL221J, VAL225J
• K-L: ALA175K, ALA177K, ARG193K, ARG208K, ARG254K, ARG256K, ARG265K, ASN181K, ASN240K, ASN242K, ASN266K, ASN267K, ASN29L, ASN34L, ASP202K, ASP259K, ASP26L, ASP40L, GLN173K, GLN183K, GLN189K, GLN196K, GLN42L, GLU188K, GLU191K, GLU210K, GLU229K, GLU239K, GLU245K, GLU24L, GLU252K, GLY178K, GLY238K, GLY258K, GLY263K, HIS199K, HIS235K, ILE223K, ILE243K, ILE255K, ILE37L, LEU257K, LYS170K, LYS172K, LYS180K, LYS20L, LYS251K, LYS260K, LYS35L, PHE176K, PHE209K, PRO190K, PRO197K, PRO21L, PRO22L, PRO23L, PRO25L, PRO32L, PRO38L, SER187K, SER28L, THR174K, THR30L, THR36L, THR41L, TRP201K, TRP253K, TRP27L, TYR182K, TYR184K, VAL185K, VAL198K, VAL200K, VAL236K, VAL237K, VAL261K, VAL262K, VAL264K, VAL31L, VAL33L, VAL39L
• K-M: ARG192M, GLN289K, GLY194M, ILE290K, VAL195M
• K-N: ALA213N, ALA215N, ALA225K, ALA250K, ALA270K, ALA275K, ALA277K, ARG193N, ARG205K, ARG241N, ARG256N, ARG273K, ARG287K, ASN203K, ASN214N, ASN240N, ASN242N, ASP259N, GLN196N, GLU191N, GLU216N, GLU239N, GLY227K, GLY238N, GLY258N, GLY272K, GLY274K, GLY279K, ILE195N, ILE223K, LEU217N, LEU257N, LYS228K, LYS251K, LYS260N, PHE206K, PHE211N, PHE269K, PRO212N, PRO218N, PRO271K, SER194N, SER224K, SER226K, THR230K, THR248K, THR278K, THR280K, TYR204K, VAL198N, VAL249K, VAL276K
• M-N: ALA175N, ALA197M, ALA225N, ALA236M, ALA275N, ALA277N, ALA281N, ALA366M, ALA384M, ARG205N, ARG208N, ARG241M, ARG254N, ARG256N, ARG286N, ARG287N, ASN198M, ASN233N, ASN273M, ASN288M, ASN386M, ASP232M, ASP237M, ASP244M, ASP276M, ASP284N, ASP361M, ASP365M, ASP385M, CYS211M, GLN169N, GLN173N, GLN231M, GLN275M, GLN289N, GLN362M, GLU229N, GLU245N, GLU247N, GLY206M, GLY212M, GLY227N, GLY238M, GLY272N, GLY277M, GLY279N, GLY291M, GLY364M, GLY379M, HIS235N, ILE167N, ILE209M, ILE223N, ILE243M, ILE279M, ILE290N, ILE295M, ILE369M, LEU171N, LEU201M, LEU231N, LEU239M, LEU242M, LEU290M, LEU383M, LYS164N, LYS165N, LYS170N, LYS172N, LYS207M, LYS228N, LYS245M, PHE176N, PHE206N, PHE269N, PHE370M, PHE377M, PRO199M, PRO204M, PRO210M, PRO232N, PRO271N, PRO283N, PRO296M, SER200M, SER224N, SER226N, SER230M, SER234N, SER235M, SER282N, SER289M, SER292M, SER368M, SER378M, THR168N, THR174N, THR213M, THR230N, THR248N, THR278M, THR278N, THR280N, THR287M, THR382M, TYR221N, TYR234M, TYR381M, VAL203M, VAL220N, VAL233M, VAL236N, VAL237N, VAL240M, VAL249N, VAL276N, VAL285N, VAL288N, VAL367M, VAL371M, VAL380M
• M-O: ARG263M, GLN42O, HIS19O, LEU239M, LEU290M, PRO21O, PRO22O
• M-P: ALA178M, ALA178P, ALA180M, ALA180P, ALA186M, ALA186P, ALA190P, ALA193P, ALA197P, ALA236P, ALA262P, ALA285M, ALA285P, ALA293P, ALA301M, ALA301P, ALA310M, ALA310P, ALA322M, ALA322P, ALA345M, ALA345P, ALA348M, ALA348P, ALA372M, ALA372P, ARG187M, ARG187P, ARG192P, ARG228M, ARG263P, ARG270M, ARG272M, ARG306M, ARG306P, ARG308M, ARG308P, ARG350M, ARG350P, ARG373M, ARG373P, ASN182M, ASN182P, ASN198M, ASN273M, ASN281M, ASN288P, ASP218M, ASP237P, ASP250M, ASP259P, ASP274M, ASP276M, ASP283M, ASP283P, ASP300M, ASP300P, ASP318M, ASP318P, ASP361M, ASP374M, ASP374P, ASP376M, CYS227M, GLN224M, GLN252M, GLN261P, GLN275M, GLN343M, GLN343P, GLN362M, GLN363M, GLU171P, GLU174P, GLU216M, GLU269M, GLU305M, GLU347M, GLU347P, GLY175P, GLY194P, GLY206P, GLY214M, GLY223M, GLY238P, GLY251M, GLY256P, GLY260P, GLY277M, GLY286P, GLY291P, GLY294P, GLY309M, GLY342M, GLY342P, GLY364M, GLY379M, HIS302M, HIS302P, ILE243M, ILE253M, ILE257P, ILE271M, ILE279M, ILE282M, ILE295P, ILE311M, ILE311P, ILE313M, ILE313P, ILE355M, LEU179M, LEU179P, LEU183M, LEU183P, LEU188M, LEU188P, LEU201M, LEU217M, LEU239P, LEU242M, LEU290P, LEU307M, LEU307P, LEU315M, LEU315P, LEU320M, LEU344M, LEU344P, LEU349M, LEU349P, LEU359M, LEU359P, LEU375M, LEU375P, LYS181M, LYS181P, LYS189M, LYS189P, LYS205M, LYS205P, LYS207P, LYS258P, PHE265P, PHE316M, PHE316P, PHE370M, PHE370P, PHE377M, PRO185M, PRO185P, PRO199P, PRO204M, PRO204P, PRO222M, PRO296P, PRO356M, PRO356P, PRO357M, PRO357P, SER173P, SER176P, SER177M, SER177P, SER191M, SER191P, SER226M, SER235P, SER284M, SER284P, SER289P, SER292P, SER314M, SER314P, SER317M, SER317P, SER346M, SER346P, SER351M, SER351P, SER354M, SER368P, SER378M, THR172P, THR184M, THR184P, THR202M, THR202P, THR215M, THR219M, THR220M, THR278M, THR287P, THR319M, THR319P, THR321M, THR321P, THR358M, THR358P, TRP248M, TRP268M, TRP304M, TRP304P, TYR234P, TYR352M, TYR352P, TYR360M, TYR381M, VAL195P, VAL203M, VAL203P, VAL221M, VAL225M, VAL249M, VAL264P, VAL266P, VAL280M, VAL299P, VAL371M, VAL371P, VAL380M
• M-Q: ALA213Q, ALA215Q, ALA366M, ARG228M, ARG241M, ARG241Q, ARG254Q, ARG256Q, ARG272M, ASN214Q, ASN233Q, ASN240Q, ASN242Q, ASN273M, ASP232M, ASP244M, ASP259Q, ASP274M, ASP276M, ASP361M, ASP365M, CYS211M, CYS227M, GLN169Q, GLN173Q, GLN219Q, GLN231M, GLN275M, GLN362M, GLN363M, GLU216M, GLU216Q, GLU229Q, GLU239Q, GLU245Q, GLU247Q, GLY212M, GLY214M, GLY238Q, GLY246M, GLY258Q, GLY364M, HIS235Q, ILE195Q, ILE223Q, ILE243M, ILE243Q, ILE244Q, ILE255Q, LEU217Q, LEU231Q, LEU257Q, LYS245M, LYS260Q, PHE209Q, PHE211Q, PRO210M, PRO212Q, PRO218Q, PRO232Q, SER226M, SER230M, SER234Q, SER247M, SER289M, THR213M, THR215M, THR230Q, TRP248M, TYR221Q, TYR234M, VAL220Q, VAL225M, VAL229M, VAL233M, VAL236Q, VAL237Q, VAL246Q, VAL261Q, VAL367M
• M-R: ALA301M, ASP218M, ASP300M, ASP361M, ASP365M, GLN298M, GLN362M, GLN363M, GLU216M, GLU24R, GLY18R, GLY297M, GLY364M, HIS19R, HIS302M, ILE257M, LEU217M, LEU359M, LYS20R, PRO21R, PRO22R, PRO23R, PRO357M, THR219M, THR220M, THR358M, TYR360M, VAL299M
• M-S: ALA178S, ALA180S, ALA186S, ALA190S, ALA285M, ALA293M, ALA372M, ARG187S, ARG270M, ARG373M, ASN182S, ASN281M, ASP250M, ASP283M, GLN224M, GLN252M, GLN343M, GLU269M, GLY251M, GLY286M, GLY342S, ILE282M, ILE313M, ILE369M, LEU179S, LEU183S, LEU188S, LEU267M, LEU349S, LYS181S, PHE265M, PHE370M, PRO185S, SER284M, SER346S, THR184S, THR254M, TRP268M, VAL266M, VAL280M, VAL371M
• M-U: ARG308M, GLU305M, SER16U, SER17U, TRP304M
• M-V: ALA178V, ALA180V, ASN182V, GLN224M, GLN252M, GLU174V, GLU269M, GLY175V, GLY223M, GLY251M, GLY255M, ILE253M, LEU179V, LEU183V, LEU267M, PHE265M, PRO222M, SER173V, SER176V, SER177V, THR172V, THR254M, VAL221M, VAL225M
• N-O: ALA175N, ALA177N, ARG193N, ARG208N, ARG254N, ARG256N, ARG265N, ASN181N, ASN266N, ASN267N, ASN29O, ASN34O, ASP202N, ASP259N, ASP26O, ASP40O, GLN173N, GLN183N, GLN189N, GLN196N, GLN42O, GLU188N, GLU191N, GLU210N, GLU229N, GLU239N, GLU245N, GLU24O, GLU252N, GLY178N, GLY238N, GLY258N, GLY263N, HIS199N, HIS235N, ILE223N, ILE243N, ILE255N, ILE37O, LEU171N, LEU257N, LYS170N, LYS172N, LYS180N, LYS20O, LYS251N, LYS260N, LYS35O, PHE176N, PHE209N, PRO190N, PRO197N, PRO21O, PRO22O, PRO23O, PRO25O, PRO32O, PRO38O, SER187N, SER28O, THR174N, THR30O, THR36O, THR41O, TRP201N, TRP253N, TRP27O, TYR182N, TYR184N, VAL185N, VAL198N, VAL200N, VAL237N, VAL261N, VAL262N, VAL264N, VAL31O, VAL33O, VAL39O
• N-P: ARG192P, GLN289N, GLY194P, ILE290N, VAL195P
• N-Q: ALA213Q, ALA215Q, ALA225N, ALA250N, ALA270N, ALA275N, ALA277N, ARG193Q, ARG205N, ARG241Q, ARG256Q, ARG273N, ARG287N, ASN203N, ASN214Q, ASN240Q, ASN242Q, ASP259Q, GLN196Q, GLU191Q, GLU216Q, GLU239Q, GLY227N, GLY238Q, GLY258Q, GLY272N, GLY274N, GLY279N, ILE195Q, ILE223N, LEU217Q, LEU257Q, LYS228N, LYS251N, LYS260Q, PHE206N, PHE211Q, PHE269N, PRO212Q, PRO218Q, PRO271N, SER194Q, SER224N, SER226N, THR230N, THR248N, THR278N, THR280N, TYR204N, VAL198Q, VAL249N, VAL276N
• P-Q: ALA175Q, ALA197P, ALA225Q, ALA236P, ALA275Q, ALA277Q, ALA281Q, ALA366P, ALA384P, ARG205Q, ARG208Q, ARG241P, ARG254Q, ARG256Q, ARG286Q, ARG287Q, ASN198P, ASN233Q, ASN273P, ASN288P, ASN386P, ASP232P, ASP237P, ASP244P, ASP276P, ASP284Q, ASP361P, ASP365P, ASP385P, CYS211P, GLN169Q, GLN173Q, GLN231P, GLN275P, GLN289Q, GLN362P, GLU229Q, GLU245Q, GLU247Q, GLY206P, GLY212P, GLY227Q, GLY238P, GLY272Q, GLY277P, GLY279Q, GLY291P, GLY364P, GLY379P, HIS235Q, ILE167Q, ILE209P, ILE223Q, ILE243P, ILE279P, ILE290Q, ILE295P, ILE369P, LEU171Q, LEU201P, LEU231Q, LEU239P, LEU242P, LEU290P, LEU383P, LYS164Q, LYS165Q, LYS170Q, LYS172Q, LYS207P, LYS228Q, LYS245P, PHE176Q, PHE206Q, PHE269Q, PHE370P, PHE377P, PRO199P, PRO204P, PRO210P, PRO232Q, PRO271Q, PRO283Q, PRO296P, SER200P, SER224Q, SER226Q, SER230P, SER234Q, SER235P, SER282Q, SER289P, SER292P, SER368P, SER378P, THR168Q, THR174Q, THR230Q, THR248Q, THR278P, THR278Q, THR280Q, THR287P, THR382P, TYR221Q, TYR234P, TYR381P, VAL203P, VAL233P, VAL236Q, VAL237Q, VAL240P, VAL249Q, VAL276Q, VAL285Q, VAL288Q, VAL367P, VAL371P, VAL380P
• P-R: ARG263P, HIS19R, LEU290P, PRO21R, PRO22R
• P-S: ALA178P, ALA178S, ALA180P, ALA180S, ALA186P, ALA186S, ALA190S, ALA193S, ALA197S, ALA236S, ALA262S, ALA285P, ALA285S, ALA293S, ALA301P, ALA301S, ALA310P, ALA310S, ALA322P, ALA345P, ALA345S, ALA348P, ALA348S, ALA372P, ALA372S, ARG187P, ARG187S, ARG192S, ARG228P, ARG263S, ARG270P, ARG272P, ARG306P, ARG306S, ARG308P, ARG308S, ARG350P, ARG350S, ARG373P, ARG373S, ASN182P, ASN182S, ASN198P, ASN273P, ASN281P, ASN288S, ASP218P, ASP237S, ASP250P, ASP259S, ASP274P, ASP276P, ASP283P, ASP283S, ASP300P, ASP300S, ASP318P, ASP318S, ASP361P, ASP374P, ASP374S, ASP376P, CYS227P, GLN224P, GLN252P, GLN261S, GLN275P, GLN343P, GLN343S, GLN362P, GLN363P, GLU171S, GLU174S, GLU216P, GLU269P, GLU305P, GLU347P, GLU347S, GLY175S, GLY194S, GLY206S, GLY214P, GLY223P, GLY238S, GLY251P, GLY256S, GLY260S, GLY277P, GLY286S, GLY291S, GLY294S, GLY309P, GLY342P, GLY342S, GLY364P, GLY379P, HIS302P, HIS302S, ILE243P, ILE253P, ILE257S, ILE271P, ILE279P, ILE282P, ILE295S, ILE311P, ILE311S, ILE313P, ILE313S, ILE355P, LEU179P, LEU179S, LEU183P, LEU183S, LEU188P, LEU188S, LEU201P, LEU217P, LEU239S, LEU242P, LEU290S, LEU307P, LEU307S, LEU315P, LEU315S, LEU320P, LEU344P, LEU344S, LEU349P, LEU349S, LEU359P, LEU359S, LEU375P, LEU375S, LYS181P, LYS181S, LYS189P, LYS189S, LYS205P, LYS205S, LYS207S, LYS258S, PHE265S, PHE316P, PHE316S, PHE370P, PHE370S, PHE377P, PRO185P, PRO185S, PRO199S, PRO204P, PRO204S, PRO222P, PRO296S, PRO356P, PRO356S, PRO357P, PRO357S, SER173S, SER176S, SER177P, SER177S, SER191P, SER191S, SER226P, SER235S, SER284P, SER284S, SER289S, SER292S, SER314P, SER314S, SER317P, SER317S, SER346P, SER346S, SER351P, SER351S, SER354P, SER368S, SER378P, THR172S, THR184P, THR184S, THR202P, THR202S, THR215P, THR219P, THR220P, THR278P, THR287S, THR319P, THR319S, THR321P, THR321S, THR358P, THR358S, TRP248P, TRP268P, TRP304P, TRP304S, TYR234S, TYR352P, TYR352S, TYR360P, TYR381P, VAL195S, VAL203P, VAL203S, VAL221P, VAL225P, VAL249P, VAL264S, VAL266S, VAL280P, VAL299S, VAL371P, VAL371S, VAL380P
• P-T: ALA213T, ALA215T, ALA366P, ARG228P, ARG241P, ARG241T, ARG254T, ARG256T, ARG272P, ASN214T, ASN233T, ASN240T, ASN242T, ASN273P, ASP232P, ASP244P, ASP259T, ASP274P, ASP276P, ASP361P, ASP365P, CYS211P, CYS227P, GLN169T, GLN173T, GLN219T, GLN231P, GLN275P, GLN362P, GLN363P, GLU216P, GLU216T, GLU229T, GLU239T, GLU245T, GLU247T, GLY212P, GLY214P, GLY238T, GLY246P, GLY258T, GLY364P, HIS235T, ILE195T, ILE223T, ILE243P, ILE243T, ILE244T, ILE255T, LEU217T, LEU231T, LEU257T, LYS228T, LYS245P, LYS260T, PHE209T, PHE211T, PRO210P, PRO212T, PRO218T, PRO232T, SER226P, SER230P, SER234T, SER247P, SER289P, THR213P, THR215P, THR230T, TRP248P, TYR221T, TYR234P, VAL220T, VAL225P, VAL229P, VAL233P, VAL236T, VAL237T, VAL246T, VAL261T, VAL367P
• P-U: ALA301P, ARG306P, ASP218P, ASP300P, ASP361P, ASP365P, GLN298P, GLN362P, GLN363P, GLU216P, GLU24U, GLU305P, GLY18U, GLY297P, GLY364P, HIS19U, HIS302P, ILE257P, LEU217P, LEU359P, LYS20U, PRO21U, PRO22U, PRO23U, PRO357P, SER16U, SER17U, THR219P, THR220P, THR358P, TRP304P, TYR360P, VAL299P
• P-V: ALA178V, ALA180V, ALA186V, ALA190V, ALA285P, ALA293P, ALA372P, ARG187V, ARG270P, ARG373P, ASN182V, ASN281P, ASP250P, ASP283P, GLN224P, GLN252P, GLN343P, GLU269P, GLY251P, GLY286P, ILE282P, ILE313P, ILE369P, LEU179V, LEU183V, LEU188V, LEU267P, LEU349V, LYS181V, PHE265P, PHE370P, PRO185V, SER284P, SER346V, THR184V, THR254P, TRP268P, VAL266P, VAL280P, VAL371P
• P-Y: ALA178Y, ALA180Y, ASN182Y, GLN224P, GLN252P, GLU174Y, GLU269P, GLY175Y, GLY223P, GLY251P, GLY255P, ILE253P, LEU179Y, LEU183Y, LEU267P, PHE265P, PRO222P, SER173Y, SER176Y, SER177Y, THR172Y, THR254P, VAL221P, VAL225P
• Q-R: ALA175Q, ALA177Q, ARG193Q, ARG208Q, ARG254Q, ARG256Q, ARG265Q, ASN181Q, ASN266Q, ASN267Q, ASN29R, ASN34R, ASP202Q, ASP259Q, ASP26R, ASP40R, GLN173Q, GLN183Q, GLN189Q, GLN196Q, GLU188Q, GLU191Q, GLU210Q, GLU229Q, GLU239Q, GLU245Q, GLU24R, GLU252Q, GLY178Q, GLY238Q, GLY258Q, GLY263Q, HIS199Q, ILE223Q, ILE243Q, ILE255Q, ILE37R, LEU257Q, LYS180Q, LYS20R, LYS251Q, LYS260Q, LYS35R, PHE176Q, PHE209Q, PRO190Q, PRO197Q, PRO21R, PRO22R, PRO23R, PRO25R, PRO32R, PRO38R, SER187Q, SER28R, THR174Q, THR30R, THR36R, THR41R, TRP201Q, TRP253Q, TRP27R, TYR182Q, TYR184Q, VAL185Q, VAL198Q, VAL200Q, VAL237Q, VAL261Q, VAL262Q, VAL264Q, VAL31R, VAL33R, VAL39R
• Q-S: ARG192S, GLN289Q, GLY194S, ILE290Q, PRO199S, VAL195S
• Q-T: ALA213T, ALA215T, ALA225Q, ALA250Q, ALA270Q, ALA275Q, ALA277Q, ARG193T, ARG205Q, ARG241T, ARG256T, ARG273Q, ARG287Q, ASN203Q, ASN214T, ASN240T, ASN242T, ASP259T, GLN196T, GLU191T, GLU216T, GLU239T, GLY227Q, GLY238T, GLY258T, GLY272Q, GLY274Q, GLY279Q, ILE195T, ILE223Q, LEU217T, LEU257T, LYS228Q, LYS251Q, LYS260T, PHE206Q, PHE211T, PHE269Q, PRO212T, PRO218T, PRO271Q, SER194T, SER224Q, SER226Q, THR230Q, THR248Q, THR278Q, THR280Q, TYR204Q, VAL198T, VAL249Q, VAL276Q
• S-T: ALA175T, ALA197S, ALA225T, ALA236S, ALA275T, ALA277T, ALA281T, ALA366S, ALA384S, ARG205T, ARG208T, ARG241S, ARG254T, ARG256T, ARG286T, ARG287T, ASN198S, ASN233T, ASN273S, ASN288S, ASN386S, ASP232S, ASP237S, ASP244S, ASP276S, ASP284T, ASP361S, ASP365S, ASP385S, CYS211S, GLN169T, GLN173T, GLN231S, GLN275S, GLN289T, GLN362S, GLU229T, GLU245T, GLU247T, GLY206S, GLY227T, GLY238S, GLY272T, GLY277S, GLY279T, GLY291S, GLY364S, GLY379S, HIS235T, ILE167T, ILE209S, ILE223T, ILE243S, ILE279S, ILE290T, ILE295S, ILE369S, LEU171T, LEU201S, LEU231T, LEU239S, LEU242S, LEU290S, LEU383S, LYS164T, LYS165T, LYS170T, LYS172T, LYS207S, LYS228T, LYS245S, PHE176T, PHE206T, PHE269T, PHE370S, PHE377S, PRO199S, PRO204S, PRO210S, PRO232T, PRO271T, PRO283T, PRO296S, SER200S, SER224T, SER226T, SER230S, SER234T, SER235S, SER282T, SER289S, SER292S, SER368S, SER378S, THR168T, THR174T, THR230T, THR248T, THR278S, THR278T, THR280T, THR287S, THR382S, TYR221T, TYR234S, TYR381S, VAL203S, VAL233S, VAL236T, VAL237T, VAL240S, VAL249T, VAL276T, VAL285T, VAL288T, VAL367S, VAL371S, VAL380S
• S-U: ARG263S, GLN42U, HIS19U, LEU239S, LEU290S, PRO21U, PRO22U
• S-V: ALA178S, ALA178V, ALA180S, ALA180V, ALA186S, ALA186V, ALA190V, ALA193V, ALA197V, ALA236V, ALA262V, ALA285S, ALA285V, ALA293V, ALA301S, ALA301V, ALA310S, ALA310V, ALA322S, ALA322V, ALA345S, ALA345V, ALA348S, ALA348V, ALA372S, ALA372V, ARG187S, ARG187V, ARG192V, ARG228S, ARG263V, ARG270S, ARG272S, ARG306S, ARG306V, ARG308S, ARG308V, ARG350S, ARG350V, ARG373S, ARG373V, ASN182S, ASN198S, ASN273S, ASN281S, ASN288V, ASP218S, ASP237V, ASP250S, ASP259V, ASP274S, ASP276S, ASP283S, ASP283V, ASP300S, ASP300V, ASP318S, ASP318V, ASP361S, ASP374S, ASP374V, ASP376S, CYS227S, GLN224S, GLN252S, GLN261V, GLN275S, GLN343S, GLN343V, GLN362S, GLN363S, GLU171V, GLU174V, GLU216S, GLU269S, GLU305S, GLU347S, GLU347V, GLY175V, GLY194V, GLY206V, GLY214S, GLY223S, GLY238V, GLY251S, GLY256V, GLY260V, GLY277S, GLY286V, GLY291V, GLY294V, GLY309S, GLY342S, GLY364S, GLY379S, HIS302S, HIS302V, ILE243S, ILE253S, ILE257V, ILE271S, ILE279S, ILE282S, ILE295V, ILE311S, ILE311V, ILE313S, ILE355S, LEU179S, LEU179V, LEU183S, LEU183V, LEU188S, LEU188V, LEU201S, LEU217S, LEU239V, LEU242S, LEU290V, LEU307S, LEU307V, LEU315V, LEU320S, LEU344S, LEU344V, LEU349S, LEU349V, LEU359S, LEU359V, LEU375S, LEU375V, LYS181S, LYS181V, LYS189S, LYS189V, LYS205S, LYS205V, LYS207V, LYS258V, PHE265V, PHE316S, PHE316V, PHE370S, PHE370V, PHE377S, PRO185S, PRO185V, PRO199V, PRO204S, PRO204V, PRO222S, PRO296V, PRO356S, PRO356V, PRO357S, PRO357V, SER173V, SER176V, SER177S, SER177V, SER191S, SER191V, SER226S, SER235V, SER284S, SER284V, SER289V, SER292V, SER314S, SER314V, SER317S, SER317V, SER346S, SER346V, SER351S, SER351V, SER354S, SER368V, SER378S, THR172V, THR184S, THR184V, THR202S, THR202V, THR215S, THR219S, THR220S, THR278S, THR287V, THR319S, THR319V, THR321S, THR321V, THR358S, TRP248S, TRP268S, TRP304S, TRP304V, TYR234V, TYR352S, TYR352V, TYR360S, TYR381S, VAL195V, VAL203S, VAL203V, VAL221S, VAL225S, VAL249S, VAL264V, VAL266V, VAL280S, VAL299V, VAL371S, VAL371V, VAL380S
• S-W: ALA213W, ALA215W, ALA366S, ARG228S, ARG241S, ARG241W, ARG254W, ARG256W, ARG272S, ASN214W, ASN233W, ASN240W, ASN242W, ASN273S, ASP232S, ASP244S, ASP259W, ASP274S, ASP276S, ASP361S, ASP365S, CYS211S, CYS227S, GLN169W, GLN173W, GLN219W, GLN231S, GLN275S, GLN362S, GLN363S, GLU216S, GLU216W, GLU229W, GLU239W, GLU245W, GLU247W, GLY212S, GLY214S, GLY238W, GLY246S, GLY258W, GLY364S, HIS235W, ILE195W, ILE223W, ILE243S, ILE243W, ILE244W, ILE255W, LEU217W, LEU231W, LEU257W, LYS245S, LYS260W, PHE209W, PHE211W, PRO210S, PRO212W, PRO218W, PRO232W, SER226S, SER230S, SER234W, SER247S, SER289S, THR213S, THR215S, THR230W, TRP248S, TYR221W, TYR234S, VAL220W, VAL225S, VAL229S, VAL233S, VAL236W, VAL237W, VAL246W, VAL261W, VAL367S
• S-X: ALA301S, ASP218S, ASP300S, ASP361S, ASP365S, GLN275S, GLN298S, GLN362S, GLN363S, GLN42X, GLU216S, GLU24X, GLY297S, GLY364S, HIS19X, HIS302S, ILE257S, LEU217S, LEU359S, LYS20X, PRO21X, PRO22X, PRO23X, PRO357S, THR219S, THR220S, THR358S, TYR360S, VAL299S
• S-Y: ALA180Y, ALA186S, ALA186Y, ALA190Y, ALA285S, ALA293S, ALA372S, ARG187Y, ARG270S, ARG373S, ASN182Y, ASN281S, ASP250S, ASP283S, GLN224S, GLN252S, GLU171Y, GLU269S, GLY251S, GLY286S, ILE282S, ILE313S, ILE369S, LEU179Y, LEU183Y, LEU188Y, LEU267S, LEU349Y, LYS181Y, PHE265S, PHE370S, PRO185Y, SER284S, THR184Y, THR254S, TRP268S, VAL266S, VAL280S, VAL371S
• S-b: ALA178b, ALA180b, ASN182b, GLN224S, GLN252S, GLU174b, GLU269S, GLY175b, GLY223S, GLY251S, GLY255S, ILE253S, LEU179b, LEU183b, LEU267S, PHE265S, PRO222S, SER173b, SER176b, SER177b, THR172b, THR254S, VAL221S, VAL225S
• T-U: ALA175T, ALA177T, ARG193T, ARG208T, ARG254T, ARG256T, ARG265T, ASN181T, ASN266T, ASN267T, ASN29U, ASN34U, ASP202T, ASP259T, ASP26U, ASP40U, GLN173T, GLN183T, GLN189T, GLN196T, GLN42U, GLU188T, GLU191T, GLU210T, GLU229T, GLU239T, GLU245T, GLU24U, GLU252T, GLY178T, GLY238T, GLY258T, GLY263T, HIS199T, HIS235T, ILE195T, ILE223T, ILE243T, ILE255T, ILE37U, LEU171T, LEU257T, LYS170T, LYS172T, LYS180T, LYS20U, LYS260T, LYS35U, PHE176T, PHE209T, PRO190T, PRO197T, PRO21U, PRO22U, PRO23U, PRO25U, PRO32U, PRO38U, SER187T, SER28U, THR174T, THR30U, THR36U, THR41U, TRP201T, TRP253T, TRP27U, TYR182T, TYR184T, TYR221T, VAL185T, VAL198T, VAL200T, VAL237T, VAL261T, VAL262T, VAL264T, VAL31U, VAL33U, VAL39U
• T-V: ARG192V, GLN289T, GLY194V, ILE290T, PRO199V, VAL195V
• T-W: ALA213W, ALA215W, ALA225T, ALA250T, ALA270T, ALA275T, ALA277T, ARG193W, ARG205T, ARG241W, ARG256W, ARG273T, ARG287T, ASN203T, ASN214W, ASN240W, ASN242W, ASP259W, GLN196W, GLU191W, GLU216W, GLU239W, GLY227T, GLY238W, GLY258W, GLY272T, GLY274T, GLY279T, ILE195W, ILE223T, LEU217W, LEU257W, LYS228T, LYS251T, LYS260W, PHE206T, PHE211W, PHE269T, PRO212W, PRO218W, PRO271T, SER194W, SER224T, SER226T, THR230T, THR248T, THR278T, THR280T, TYR204T, VAL198W, VAL249T, VAL276T
• V-W: ALA175W, ALA197V, ALA225W, ALA236V, ALA275W, ALA277W, ALA281W, ALA366V, ALA384V, ARG205W, ARG208W, ARG241V, ARG254W, ARG256W, ARG286W, ARG287W, ASN198V, ASN233W, ASN273V, ASN288V, ASN386V, ASP232V, ASP237V, ASP244V, ASP276V, ASP284W, ASP361V, ASP365V, ASP385V, CYS211V, GLN169W, GLN173W, GLN231V, GLN275V, GLN289W, GLN362V, GLU229W, GLU245W, GLU247W, GLY206V, GLY212V, GLY227W, GLY238V, GLY272W, GLY277V, GLY279W, GLY291V, GLY364V, GLY379V, HIS235W, ILE167W, ILE209V, ILE223W, ILE243V, ILE279V, ILE290W, ILE295V, ILE369V, LEU171W, LEU201V, LEU231W, LEU239V, LEU242V, LEU290V, LEU383V, LYS164W, LYS165W, LYS170W, LYS172W, LYS207V, LYS228W, LYS245V, PHE176W, PHE206W, PHE269W, PHE370V, PHE377V, PRO199V, PRO204V, PRO210V, PRO232W, PRO271W, PRO283W, PRO296V, SER200V, SER224W, SER226W, SER230V, SER234W, SER235V, SER282W, SER289V, SER292V, SER368V, SER378V, THR168W, THR174W, THR230W, THR248W, THR278V, THR278W, THR280W, THR287V, THR382V, TYR221W, TYR234V, TYR381V, VAL203V, VAL233V, VAL236W, VAL237W, VAL240V, VAL249W, VAL276W, VAL285W, VAL288W, VAL367V, VAL371V, VAL380V
• V-X: ARG263V, HIS19X, LEU290V, PRO21X, PRO22X
• V-Y: ALA178V, ALA178Y, ALA180V, ALA180Y, ALA186V, ALA186Y, ALA190Y, ALA193Y, ALA197Y, ALA236Y, ALA262Y, ALA285V, ALA285Y, ALA293Y, ALA301V, ALA301Y, ALA310V, ALA310Y, ALA322V, ALA322Y, ALA345V, ALA345Y, ALA348V, ALA348Y, ALA372V, ALA372Y, ARG187V, ARG187Y, ARG192Y, ARG228V, ARG263Y, ARG270V, ARG272V, ARG306V, ARG306Y, ARG308V, ARG308Y, ARG350V, ARG350Y, ARG373V, ARG373Y, ASN182V, ASN198V, ASN273V, ASN281V, ASN288Y, ASP218V, ASP237Y, ASP250V, ASP259Y, ASP274V, ASP276V, ASP283V, ASP283Y, ASP300V, ASP300Y, ASP318V, ASP318Y, ASP361V, ASP374V, ASP374Y, ASP376V, CYS227V, GLN224V, GLN252V, GLN261Y, GLN275V, GLN343V, GLN362V, GLN363V, GLU171Y, GLU174Y, GLU216V, GLU269V, GLU305V, GLU347V, GLU347Y, GLY175Y, GLY194Y, GLY206Y, GLY214V, GLY223V, GLY238Y, GLY251V, GLY256Y, GLY260Y, GLY277V, GLY286Y, GLY291Y, GLY294Y, GLY309V, GLY364V, GLY379V, HIS302V, HIS302Y, ILE243V, ILE253V, ILE257Y, ILE271V, ILE279V, ILE282V, ILE295Y, ILE311V, ILE311Y, ILE313V, ILE313Y, ILE355V, LEU179V, LEU179Y, LEU183V, LEU183Y, LEU188V, LEU188Y, LEU201V, LEU217V, LEU239Y, LEU242V, LEU290Y, LEU307V, LEU307Y, LEU315V, LEU315Y, LEU320V, LEU344V, LEU344Y, LEU349V, LEU349Y, LEU359V, LEU359Y, LEU375V, LEU375Y, LYS181V, LYS181Y, LYS189V, LYS189Y, LYS205V, LYS205Y, LYS207Y, LYS258Y, PHE265Y, PHE316V, PHE316Y, PHE370V, PHE370Y, PHE377V, PRO185V, PRO185Y, PRO199Y, PRO204V, PRO204Y, PRO222V, PRO296Y, PRO356V, PRO356Y, PRO357V, PRO357Y, SER173Y, SER176Y, SER177V, SER177Y, SER191V, SER191Y, SER226V, SER235Y, SER284V, SER284Y, SER289Y, SER292Y, SER314V, SER314Y, SER317V, SER317Y, SER346V, SER346Y, SER351V, SER351Y, SER354V, SER368Y, SER378V, THR172Y, THR184V, THR184Y, THR202V, THR202Y, THR215V, THR219V, THR220V, THR278V, THR287Y, THR319V, THR319Y, THR321V, THR321Y, THR358V, THR358Y, TRP248V, TRP268V, TRP304V, TRP304Y, TYR234Y, TYR352V, TYR352Y, TYR360V, TYR381V, VAL195Y, VAL203V, VAL203Y, VAL221V, VAL225V, VAL249V, VAL264Y, VAL266Y, VAL280V, VAL299Y, VAL371V, VAL371Y, VAL380V
• V-Z: ALA213Z, ALA215Z, ALA366V, ARG228V, ARG241V, ARG241Z, ARG254Z, ARG256Z, ARG272V, ASN214Z, ASN233Z, ASN240Z, ASN242Z, ASN273V, ASP232V, ASP244V, ASP259Z, ASP274V, ASP276V, ASP361V, ASP365V, CYS211V, CYS227V, GLN169Z, GLN173Z, GLN219Z, GLN231V, GLN275V, GLN362V, GLN363V, GLU216V, GLU216Z, GLU229Z, GLU239Z, GLU245Z, GLU247Z, GLY212V, GLY214V, GLY238Z, GLY246V, GLY258Z, GLY364V, HIS235Z, ILE195Z, ILE223Z, ILE243V, ILE243Z, ILE244Z, ILE255Z, LEU217Z, LEU231Z, LEU257Z, LYS245V, LYS260Z, PHE209Z, PHE211Z, PRO210V, PRO212Z, PRO218Z, PRO232Z, SER226V, SER230V, SER234Z, SER247V, SER289V, THR213V, THR215V, THR230Z, TRP248V, TYR221Z, TYR234V, VAL220Z, VAL225V, VAL229V, VAL233V, VAL236Z, VAL237Z, VAL246Z, VAL261Z, VAL367V
• V-a: ALA301V, ASP218V, ASP300V, ASP361V, ASP365V, GLN275V, GLN298V, GLN362V, GLN363V, GLN42a, GLU216V, GLU24a, GLY297V, GLY364V, HIS19a, HIS302V, ILE257V, LEU217V, LEU359V, LYS20a, PRO21a, PRO22a, PRO23a, PRO357V, THR219V, THR220V, THR358V, TYR360V, VAL299V
• V-b: ALA180b, ALA186V, ALA186b, ALA190b, ALA285V, ALA293V, ALA372V, ARG187b, ARG270V, ARG373V, ASN182b, ASN281V, ASP250V, ASP283V, GLN224V, GLN252V, GLU171b, GLU269V, GLY251V, GLY286V, ILE282V, ILE313V, ILE369V, LEU179b, LEU183b, LEU188b, LEU267V, LEU349b, LYS181b, PHE265V, PHE370V, PRO185b, SER284V, THR184b, THR254V, TRP268V, VAL266V, VAL280V, VAL371V
• V-e: ALA178e, ALA180e, ASN182e, GLN224V, GLN252V, GLU174e, GLU269V, GLY175e, GLY223V, GLY251V, GLY255V, ILE253V, LEU179e, LEU183e, LEU267V, PHE265V, PRO222V, SER173e, SER176e, SER177e, THR254V, VAL221V, VAL225V
• W-X: ALA175W, ALA177W, ARG193W, ARG208W, ARG254W, ARG256W, ARG265W, ASN181W, ASN266W, ASN267W, ASN29X, ASN34X, ASP202W, ASP259W, ASP26X, ASP40X, GLN173W, GLN183W, GLN189W, GLN196W, GLN42X, GLU188W, GLU191W, GLU210W, GLU229W, GLU239W, GLU245W, GLU24X, GLU252W, GLY178W, GLY238W, GLY258W, GLY263W, HIS199W, ILE223W, ILE243W, ILE255W, ILE37X, LEU171W, LEU257W, LYS170W, LYS172W, LYS180W, LYS20X, LYS251W, LYS260W, LYS35X, PHE176W, PHE209W, PRO190W, PRO197W, PRO21X, PRO22X, PRO23X, PRO25X, PRO32X, PRO38X, SER187W, SER28X, THR174W, THR30X, THR36X, THR41X, TRP201W, TRP253W, TRP27X, TYR182W, TYR184W, VAL185W, VAL198W, VAL200W, VAL237W, VAL261W, VAL262W, VAL264W, VAL31X, VAL33X, VAL39X
• W-Y: ARG192Y, GLN289W, GLY194Y, ILE290W, PRO199Y, VAL195Y
• W-Z: ALA213Z, ALA215Z, ALA225W, ALA250W, ALA270W, ALA275W, ALA277W, ARG193Z, ARG205W, ARG241Z, ARG256Z, ARG273W, ARG287W, ASN203W, ASN214Z, ASN240Z, ASN242Z, ASP259Z, GLN196Z, GLU191Z, GLU216Z, GLU239Z, GLY227W, GLY238Z, GLY258Z, GLY272W, GLY274W, GLY279W, ILE195Z, ILE223W, LEU217Z, LEU257Z, LYS228W, LYS251W, LYS260Z, PHE206W, PHE211Z, PHE269W, PRO212Z, PRO218Z, PRO271W, SER194Z, SER224W, SER226W, THR230W, THR248W, THR278W, THR280W, TYR204W, VAL198Z, VAL249W, VAL276W
• Y-Z: ALA175Z, ALA197Y, ALA225Z, ALA236Y, ALA275Z, ALA277Z, ALA281Z, ALA366Y, ALA384Y, ARG205Z, ARG208Z, ARG241Y, ARG254Z, ARG256Z, ARG286Z, ARG287Z, ASN198Y, ASN233Z, ASN273Y, ASN288Y, ASN386Y, ASP232Y, ASP237Y, ASP244Y, ASP276Y, ASP284Z, ASP361Y, ASP365Y, ASP385Y, CYS211Y, GLN169Z, GLN173Z, GLN231Y, GLN275Y, GLN289Z, GLN362Y, GLU229Z, GLU245Z, GLU247Z, GLY206Y, GLY212Y, GLY227Z, GLY238Y, GLY272Z, GLY277Y, GLY279Z, GLY291Y, GLY364Y, GLY379Y, HIS235Z, ILE167Z, ILE209Y, ILE223Z, ILE243Y, ILE279Y, ILE290Z, ILE295Y, ILE369Y, LEU171Z, LEU201Y, LEU231Z, LEU239Y, LEU242Y, LEU290Y, LEU383Y, LYS164Z, LYS165Z, LYS170Z, LYS172Z, LYS207Y, LYS228Z, LYS245Y, PHE176Z, PHE206Z, PHE269Z, PHE370Y, PHE377Y, PRO199Y, PRO204Y, PRO210Y, PRO232Z, PRO271Z, PRO283Z, PRO296Y, SER200Y, SER224Z, SER226Z, SER230Y, SER234Z, SER235Y, SER282Z, SER289Y, SER292Y, SER368Y, SER378Y, THR168Z, THR174Z, THR230Z, THR248Z, THR278Y, THR278Z, THR280Z, THR287Y, THR382Y, TYR221Z, TYR234Y, TYR381Y, VAL203Y, VAL220Z, VAL233Y, VAL236Z, VAL237Z, VAL240Y, VAL249Z, VAL276Z, VAL285Z, VAL288Z, VAL367Y, VAL371Y, VAL380Y
• Y-a: ARG263Y, HIS19a, LEU290Y, PRO21a, PRO22a
• Y-b: ALA178Y, ALA178b, ALA180Y, ALA180b, ALA186Y, ALA186b, ALA190b, ALA193b, ALA197b, ALA236b, ALA262b, ALA285Y, ALA285b, ALA293b, ALA301Y, ALA301b, ALA310Y, ALA310b, ALA322Y, ALA345Y, ALA345b, ALA348Y, ALA348b, ALA372Y, ALA372b, ARG187Y, ARG187b, ARG192b, ARG228Y, ARG263b, ARG270Y, ARG272Y, ARG306Y, ARG306b, ARG308Y, ARG308b, ARG350Y, ARG350b, ARG373Y, ARG373b, ASN182Y, ASN198Y, ASN273Y, ASN281Y, ASN288b, ASP218Y, ASP237b, ASP250Y, ASP259b, ASP274Y, ASP276Y, ASP283Y, ASP283b, ASP300Y, ASP300b, ASP318Y, ASP318b, ASP361Y, ASP374Y, ASP374b, ASP376Y, CYS227Y, GLN224Y, GLN252Y, GLN261b, GLN275Y, GLN343b, GLN362Y, GLN363Y, GLU171b, GLU174b, GLU216Y, GLU269Y, GLU305Y, GLU347Y, GLU347b, GLY175b, GLY194b, GLY206b, GLY214Y, GLY223Y, GLY238b, GLY251Y, GLY256b, GLY260b, GLY277Y, GLY286b, GLY291b, GLY294b, GLY309Y, GLY342b, GLY364Y, GLY379Y, HIS302Y, HIS302b, ILE243Y, ILE253Y, ILE257b, ILE271Y, ILE279Y, ILE282Y, ILE295b, ILE311Y, ILE311b, ILE313Y, ILE313b, ILE355Y, ILE369b, LEU179Y, LEU179b, LEU183Y, LEU183b, LEU188Y, LEU188b, LEU201Y, LEU217Y, LEU239b, LEU242Y, LEU290b, LEU307Y, LEU307b, LEU315Y, LEU315b, LEU320Y, LEU344Y, LEU344b, LEU349Y, LEU349b, LEU359Y, LEU359b, LEU375Y, LEU375b, LYS181Y, LYS181b, LYS189Y, LYS189b, LYS205Y, LYS205b, LYS207b, LYS258b, PHE265b, PHE316Y, PHE316b, PHE370Y, PHE370b, PHE377Y, PRO185Y, PRO185b, PRO199b, PRO204Y, PRO204b, PRO222Y, PRO296b, PRO356Y, PRO356b, PRO357Y, PRO357b, SER173b, SER176b, SER177Y, SER177b, SER191Y, SER191b, SER226Y, SER235b, SER284Y, SER284b, SER289b, SER292b, SER314Y, SER314b, SER317Y, SER317b, SER346Y, SER346b, SER351Y, SER351b, SER354Y, SER368b, SER378Y, THR172b, THR184Y, THR184b, THR202Y, THR202b, THR215Y, THR219Y, THR220Y, THR278Y, THR287b, THR319Y, THR319b, THR321Y, THR358Y, THR358b, TRP248Y, TRP268Y, TRP304Y, TRP304b, TYR234b, TYR352Y, TYR352b, TYR360Y, TYR381Y, VAL195b, VAL203Y, VAL203b, VAL221Y, VAL225Y, VAL249Y, VAL264b, VAL266b, VAL280Y, VAL299b, VAL371Y, VAL371b, VAL380Y
• Y-c: ALA213c, ALA215c, ALA366Y, ARG228Y, ARG241Y, ARG241c, ARG254c, ARG256c, ARG272Y, ASN214c, ASN233c, ASN240c, ASN242c, ASN273Y, ASP232Y, ASP244Y, ASP259c, ASP274Y, ASP276Y, ASP361Y, ASP365Y, CYS211Y, CYS227Y, GLN169c, GLN173c, GLN219c, GLN231Y, GLN275Y, GLN362Y, GLN363Y, GLU216Y, GLU216c, GLU229c, GLU239c, GLU245c, GLU247c, GLY212Y, GLY214Y, GLY238c, GLY246Y, GLY258c, GLY364Y, HIS235c, ILE195c, ILE223c, ILE243Y, ILE243c, ILE244c, ILE255c, LEU217c, LEU231c, LEU257c, LYS245Y, LYS260c, PHE209c, PHE211c, PRO210Y, PRO212c, PRO218c, PRO232c, SER226Y, SER230Y, SER234c, SER247Y, THR213Y, THR215Y, THR230c, TRP248Y, TYR221c, TYR234Y, VAL220c, VAL225Y, VAL229Y, VAL233Y, VAL236c, VAL237c, VAL246c, VAL261c, VAL367Y
• Y-d: ALA301Y, ASP218Y, ASP300Y, ASP361Y, ASP365Y, GLN275Y, GLN298Y, GLN362Y, GLN363Y, GLN42d, GLU216Y, GLU24d, GLY297Y, GLY364Y, HIS19d, HIS302Y, ILE257Y, LEU217Y, LEU359Y, LYS20d, PRO21d, PRO22d, PRO23d, PRO357Y, THR219Y, THR220Y, THR358Y, TYR360Y, VAL299Y
• Y-e: ALA178e, ALA180e, ALA186Y, ALA186e, ALA190e, ALA285Y, ALA293Y, ALA372Y, ARG187e, ARG270Y, ARG373Y, ASN182e, ASN281Y, ASP250Y, ASP283Y, GLN224Y, GLN252Y, GLU171e, GLU269Y, GLY251Y, GLY286Y, ILE282Y, ILE313Y, ILE369Y, LEU179e, LEU183e, LEU188e, LEU267Y, LEU349e, LYS181e, PHE265Y, PHE370Y, PRO185e, SER284Y, THR184e, THR254Y, TRP268Y, VAL266Y, VAL280Y, VAL371Y
• Y-h: ALA178h, ALA180h, ASN182h, GLN224Y, GLN252Y, GLU174h, GLU269Y, GLY175h, GLY223Y, GLY251Y, GLY255Y, ILE253Y, LEU179h, LEU183h, LEU267Y, PHE265Y, PRO222Y, SER173h, SER176h, SER177h, THR254Y, VAL221Y, VAL225Y
• Z-a: ALA175Z, ALA177Z, ARG193Z, ARG208Z, ARG254Z, ARG256Z, ARG265Z, ASN181Z, ASN240Z, ASN242Z, ASN266Z, ASN267Z, ASN29a, ASN34a, ASP202Z, ASP259Z, ASP26a, ASP40a, GLN173Z, GLN183Z, GLN189Z, GLN196Z, GLN42a, GLU188Z, GLU191Z, GLU210Z, GLU229Z, GLU239Z, GLU245Z, GLU24a, GLU252Z, GLY178Z, GLY238Z, GLY258Z, GLY263Z, HIS199Z, ILE223Z, ILE243Z, ILE255Z, ILE37a, LEU171Z, LEU257Z, LYS170Z, LYS172Z, LYS180Z, LYS20a, LYS251Z, LYS260Z, LYS35a, PHE176Z, PHE209Z, PRO190Z, PRO197Z, PRO21a, PRO22a, PRO23a, PRO25a, PRO32a, PRO38a, SER187Z, SER28a, THR174Z, THR30a, THR36a, THR41a, TRP201Z, TRP253Z, TRP27a, TYR182Z, TYR184Z, TYR221Z, VAL185Z, VAL198Z, VAL200Z, VAL236Z, VAL237Z, VAL261Z, VAL262Z, VAL264Z, VAL31a, VAL33a, VAL39a
• Z-b: ARG192b, GLN289Z, GLY194b, ILE290Z, PRO199b, VAL195b
• Z-c: ALA213c, ALA215c, ALA225Z, ALA250Z, ALA270Z, ALA275Z, ALA277Z, ARG193c, ARG205Z, ARG241c, ARG256c, ARG273Z, ARG287Z, ASN203Z, ASN214c, ASN240c, ASN242c, ASP259c, GLN196c, GLU191c, GLU216c, GLU239c, GLY227Z, GLY238c, GLY258c, GLY272Z, GLY274Z, GLY279Z, ILE195c, ILE223Z, LEU217c, LEU257c, LYS228Z, LYS251Z, LYS260c, PHE206Z, PHE211c, PHE269Z, PRO212c, PRO218c, PRO271Z, SER194c, SER224Z, SER226Z, THR230Z, THR248Z, THR278Z, THR280Z, TYR204Z, VAL198c, VAL249Z, VAL276Z
• b-c: ALA175c, ALA197b, ALA225c, ALA236b, ALA275c, ALA277c, ALA281c, ALA366b, ALA384b, ARG205c, ARG208c, ARG241b, ARG254c, ARG256c, ARG286c, ARG287c, ASN198b, ASN233c, ASN273b, ASN288b, ASN386b, ASP232b, ASP237b, ASP244b, ASP276b, ASP284c, ASP361b, ASP365b, ASP385b, CYS211b, GLN169c, GLN173c, GLN231b, GLN275b, GLN289c, GLN362b, GLU229c, GLU245c, GLU247c, GLY206b, GLY212b, GLY227c, GLY238b, GLY272c, GLY277b, GLY279c, GLY291b, GLY364b, GLY379b, HIS235c, ILE167c, ILE209b, ILE223c, ILE243b, ILE279b, ILE290c, ILE295b, LEU171c, LEU201b, LEU231c, LEU239b, LEU242b, LEU290b, LEU383b, LYS164c, LYS165c, LYS170c, LYS172c, LYS207b, LYS228c, LYS245b, PHE176c, PHE206c, PHE269c, PHE370b, PHE377b, PRO199b, PRO204b, PRO210b, PRO232c, PRO271c, PRO283c, PRO296b, SER200b, SER224c, SER226c, SER230b, SER234c, SER235b, SER282c, SER289b, SER292b, SER368b, SER378b, THR168c, THR174c, THR230c, THR248c, THR278b, THR278c, THR280c, THR287b, THR382b, TYR221c, TYR234b, TYR381b, VAL203b, VAL233b, VAL236c, VAL237c, VAL240b, VAL249c, VAL276c, VAL285c, VAL288c, VAL367b, VAL371b, VAL380b
• b-d: ARG263b, HIS19d, LEU290b, PRO21d, PRO22d
• b-e: ALA178b, ALA178e, ALA180b, ALA180e, ALA186b, ALA186e, ALA190e, ALA193e, ALA197e, ALA236e, ALA262e, ALA285b, ALA285e, ALA293e, ALA301b, ALA301e, ALA310b, ALA310e, ALA345b, ALA345e, ALA348b, ALA348e, ALA372b, ALA372e, ARG187b, ARG187e, ARG192e, ARG228b, ARG263e, ARG270b, ARG272b, ARG306b, ARG306e, ARG308b, ARG308e, ARG350b, ARG350e, ARG373b, ARG373e, ASN182b, ASN198b, ASN273b, ASN281b, ASN288e, ASP218b, ASP237e, ASP250b, ASP259e, ASP274b, ASP276b, ASP283b, ASP283e, ASP300b, ASP300e, ASP318b, ASP318e, ASP361b, ASP374b, ASP374e, ASP376b, CYS227b, GLN224b, GLN252b, GLN261e, GLN275b, GLN343b, GLN343e, GLN362b, GLN363b, GLU171e, GLU174e, GLU216b, GLU269b, GLU305b, GLU347b, GLU347e, GLY175e, GLY194e, GLY206e, GLY214b, GLY223b, GLY238e, GLY251b, GLY256e, GLY260e, GLY277b, GLY286e, GLY291e, GLY294e, GLY309b, GLY342b, GLY364b, GLY379b, HIS302b, HIS302e, ILE243b, ILE253b, ILE257e, ILE271b, ILE279b, ILE282b, ILE295e, ILE311b, ILE311e, ILE313b, ILE355b, LEU179b, LEU179e, LEU183b, LEU183e, LEU188b, LEU188e, LEU201b, LEU217b, LEU239e, LEU242b, LEU290e, LEU307b, LEU307e, LEU315b, LEU315e, LEU320b, LEU320e, LEU344b, LEU344e, LEU349b, LEU349e, LEU359b, LEU359e, LEU375b, LEU375e, LYS181b, LYS181e, LYS189b, LYS189e, LYS205b, LYS205e, LYS207e, LYS258e, PHE265e, PHE316b, PHE316e, PHE370b, PHE370e, PHE377b, PRO185b, PRO185e, PRO199e, PRO204b, PRO204e, PRO222b, PRO296e, PRO356b, PRO356e, PRO357b, PRO357e, SER173e, SER176e, SER177b, SER177e, SER191b, SER191e, SER226b, SER235e, SER284b, SER284e, SER289e, SER292e, SER314b, SER314e, SER317b, SER317e, SER346b, SER346e, SER351b, SER351e, SER354b, SER368e, SER378b, THR172e, THR184b, THR184e, THR202b, THR202e, THR215b, THR219b, THR220b, THR278b, THR287e, THR319b, THR319e, THR321e, THR358b, THR358e, TRP248b, TRP268b, TRP304b, TRP304e, TYR234e, TYR352b, TYR352e, TYR360b, TYR381b, VAL195e, VAL203b, VAL203e, VAL221b, VAL225b, VAL249b, VAL264e, VAL266e, VAL280b, VAL299e, VAL371b, VAL371e, VAL380b
• b-f: ALA213f, ALA215f, ALA366b, ARG228b, ARG241b, ARG241f, ARG254f, ARG256f, ARG272b, ASN214f, ASN233f, ASN240f, ASN242f, ASN273b, ASP232b, ASP244b, ASP259f, ASP274b, ASP276b, ASP361b, ASP365b, CYS211b, CYS227b, GLN169f, GLN173f, GLN219f, GLN231b, GLN275b, GLN362b, GLN363b, GLU216b, GLU216f, GLU229f, GLU239f, GLU245f, GLU247f, GLY212b, GLY214b, GLY238f, GLY246b, GLY258f, GLY364b, HIS235f, ILE195f, ILE223f, ILE243b, ILE243f, ILE244f, ILE255f, LEU217f, LEU231f, LEU257f, LYS245b, LYS260f, PHE209f, PHE211f, PRO210b, PRO212f, PRO218f, PRO232f, SER226b, SER230b, SER234f, SER247b, SER289b, THR213b, THR215b, THR230f, TRP248b, TYR221f, TYR234b, VAL220f, VAL225b, VAL229b, VAL233b, VAL236f, VAL237f, VAL246f, VAL261f, VAL367b
• b-g: ALA301b, ASP218b, ASP300b, ASP361b, ASP365b, GLN275b, GLN298b, GLN362b, GLN363b, GLN42g, GLU216b, GLU24g, GLY18g, GLY297b, GLY364b, HIS19g, HIS302b, ILE257b, LEU217b, LEU359b, LYS20g, PRO21g, PRO22g, PRO23g, PRO357b, THR219b, THR220b, THR358b, TYR360b, VAL299b
• b-h: ALA180h, ALA186h, ALA190h, ALA285b, ALA293b, ALA372b, ARG187h, ARG270b, ARG373b, ASN182h, ASN281b, ASP250b, ASP283b, GLN224b, GLN252b, GLU269b, GLY251b, GLY286b, ILE282b, ILE313b, ILE369b, LEU179h, LEU183h, LEU188h, LEU267b, LEU349h, LYS181h, PHE265b, PHE370b, PRO185h, SER284b, THR184h, THR254b, TRP268b, VAL266b, VAL280b, VAL371b
• b-k: ALA178k, ALA180k, ASN182k, GLN224b, GLN252b, GLU174k, GLU269b, GLY175k, GLY223b, GLY251b, GLY255b, ILE253b, LEU179k, LEU183k, LEU267b, PHE265b, PRO222b, SER173k, SER176k, SER177k, THR172k, THR254b, VAL221b, VAL225b
• c-d: ALA175c, ALA177c, ARG193c, ARG208c, ARG241c, ARG254c, ARG256c, ARG265c, ASN181c, ASN240c, ASN242c, ASN266c, ASN267c, ASN29d, ASN34d, ASP202c, ASP259c, ASP26d, ASP40d, GLN173c, GLN183c, GLN189c, GLN196c, GLN42d, GLU188c, GLU191c, GLU210c, GLU229c, GLU239c, GLU245c, GLU24d, GLU252c, GLY178c, GLY238c, GLY258c, GLY263c, HIS199c, ILE223c, ILE243c, ILE255c, ILE37d, LEU257c, LYS170c, LYS172c, LYS180c, LYS20d, LYS251c, LYS260c, LYS35d, PHE176c, PHE209c, PRO190c, PRO197c, PRO21d, PRO22d, PRO23d, PRO25d, PRO32d, PRO38d, SER187c, SER28d, THR174c, THR30d, THR36d, THR41d, TRP201c, TRP253c, TRP27d, TYR182c, TYR184c, VAL185c, VAL198c, VAL200c, VAL237c, VAL261c, VAL262c, VAL264c, VAL31d, VAL33d, VAL39d
• c-e: ARG192e, GLN289c, GLY194e, ILE290c, PRO199e, VAL195e
• c-f: ALA213f, ALA215f, ALA225c, ALA250c, ALA270c, ALA275c, ALA277c, ARG193f, ARG205c, ARG241f, ARG256f, ARG273c, ARG287c, ASN203c, ASN214f, ASN240f, ASN242f, ASP259f, GLN196f, GLU191f, GLU216f, GLU239f, GLY227c, GLY238f, GLY258f, GLY272c, GLY274c, GLY279c, ILE195f, ILE223c, LEU217f, LEU257f, LYS228c, LYS251c, LYS260f, PHE206c, PHE211f, PHE269c, PRO212f, PRO218f, PRO271c, SER194f, SER224c, SER226c, THR230c, THR248c, THR278c, THR280c, TYR204c, VAL198f, VAL249c, VAL276c
• e-f: ALA175f, ALA197e, ALA225f, ALA236e, ALA275f, ALA277f, ALA281f, ALA366e, ALA384e, ARG205f, ARG208f, ARG241e, ARG254f, ARG256f, ARG286f, ARG287f, ASN198e, ASN233f, ASN273e, ASN288e, ASN386e, ASP232e, ASP237e, ASP244e, ASP276e, ASP284f, ASP361e, ASP365e, ASP385e, CYS211e, GLN169f, GLN173f, GLN231e, GLN275e, GLN289f, GLN362e, GLU229f, GLU245f, GLU247f, GLY206e, GLY212e, GLY227f, GLY238e, GLY272f, GLY277e, GLY279f, GLY291e, GLY364e, GLY379e, HIS235f, ILE167f, ILE209e, ILE223f, ILE243e, ILE279e, ILE290f, ILE295e, ILE369e, LEU171f, LEU201e, LEU231f, LEU239e, LEU242e, LEU290e, LEU383e, LYS164f, LYS165f, LYS170f, LYS172f, LYS207e, LYS228f, LYS245e, PHE176f, PHE206f, PHE269f, PHE370e, PHE377e, PRO199e, PRO204e, PRO210e, PRO232f, PRO271f, PRO283f, PRO296e, SER200e, SER224f, SER226f, SER230e, SER234f, SER235e, SER282f, SER289e, SER292e, SER368e, SER378e, THR168f, THR174f, THR230f, THR248f, THR278e, THR278f, THR280f, THR287e, THR382e, TYR221f, TYR234e, TYR381e, VAL203e, VAL220f, VAL233e, VAL236f, VAL237f, VAL240e, VAL249f, VAL276f, VAL285f, VAL288f, VAL367e, VAL371e, VAL380e
• e-g: ARG263e, HIS19g, LEU290e, PRO21g, PRO22g
• e-h: ALA178e, ALA178h, ALA180e, ALA180h, ALA186e, ALA186h, ALA190h, ALA193h, ALA197h, ALA236h, ALA262h, ALA285e, ALA285h, ALA293h, ALA301e, ALA301h, ALA310e, ALA310h, ALA322e, ALA345e, ALA345h, ALA348e, ALA348h, ALA372e, ALA372h, ARG187e, ARG187h, ARG192h, ARG228e, ARG263h, ARG270e, ARG272e, ARG306e, ARG306h, ARG308e, ARG308h, ARG350e, ARG350h, ARG373e, ARG373h, ASN182e, ASN182h, ASN198e, ASN273e, ASN281e, ASN288h, ASP218e, ASP237h, ASP250e, ASP259h, ASP274e, ASP276e, ASP283e, ASP283h, ASP300e, ASP300h, ASP318e, ASP318h, ASP361e, ASP374e, ASP374h, ASP376e, CYS227e, GLN224e, GLN252e, GLN261h, GLN275e, GLN343e, GLN343h, GLN362e, GLN363e, GLU171h, GLU174h, GLU216e, GLU269e, GLU305e, GLU347e, GLU347h, GLY175h, GLY194h, GLY206h, GLY214e, GLY223e, GLY238h, GLY251e, GLY256h, GLY260h, GLY277e, GLY286h, GLY291h, GLY294h, GLY309e, GLY342h, GLY364e, GLY379e, HIS302e, HIS302h, ILE243e, ILE253e, ILE257h, ILE271e, ILE279e, ILE282e, ILE295h, ILE311e, ILE311h, ILE313e, ILE355e, LEU179e, LEU179h, LEU183e, LEU183h, LEU188e, LEU188h, LEU201e, LEU217e, LEU239h, LEU242e, LEU290h, LEU307e, LEU307h, LEU315e, LEU315h, LEU320e, LEU320h, LEU344e, LEU344h, LEU349e, LEU349h, LEU359e, LEU359h, LEU375e, LEU375h, LYS181e, LYS181h, LYS189e, LYS189h, LYS205e, LYS205h, LYS207h, LYS258h, PHE265h, PHE316e, PHE316h, PHE370e, PHE370h, PHE377e, PRO185e, PRO185h, PRO199h, PRO204e, PRO204h, PRO222e, PRO296h, PRO356e, PRO356h, PRO357e, PRO357h, SER173h, SER176h, SER177e, SER177h, SER191e, SER191h, SER226e, SER235h, SER284e, SER284h, SER289h, SER292h, SER314e, SER314h, SER317e, SER317h, SER346e, SER346h, SER351e, SER351h, SER354e, SER368h, SER378e, THR172h, THR184e, THR184h, THR202e, THR202h, THR213e, THR215e, THR219e, THR220e, THR278e, THR287h, THR319e, THR319h, THR321e, THR358e, THR358h, TRP248e, TRP268e, TRP304e, TRP304h, TYR234h, TYR352e, TYR352h, TYR360e, TYR381e, VAL195h, VAL203e, VAL203h, VAL221e, VAL225e, VAL249e, VAL264h, VAL266h, VAL280e, VAL299h, VAL371e, VAL371h, VAL380e
• e-i: ALA213i, ALA215i, ALA366e, ARG228e, ARG241e, ARG241i, ARG254i, ARG256i, ARG272e, ASN214i, ASN233i, ASN240i, ASN242i, ASN273e, ASP232e, ASP244e, ASP259i, ASP274e, ASP276e, ASP361e, ASP365e, CYS211e, CYS227e, GLN169i, GLN173i, GLN219i, GLN231e, GLN275e, GLN298e, GLN362e, GLN363e, GLU216e, GLU216i, GLU229i, GLU239i, GLU245i, GLU247i, GLY212e, GLY214e, GLY238i, GLY246e, GLY258i, GLY364e, HIS235i, ILE195i, ILE223i, ILE243e, ILE243i, ILE244i, ILE255i, LEU217i, LEU231i, LEU257i, LYS245e, LYS260i, PHE209i, PHE211i, PRO210e, PRO212i, PRO218i, PRO232i, SER226e, SER230e, SER234i, SER247e, SER289e, THR213e, THR215e, THR230i, TRP248e, TYR221i, TYR234e, VAL220i, VAL225e, VAL229e, VAL233e, VAL236i, VAL237i, VAL246i, VAL261i, VAL367e
• e-j: ALA301e, ASP218e, ASP300e, ASP361e, ASP365e, GLN298e, GLN362e, GLN363e, GLU216e, GLU24j, GLY18j, GLY297e, GLY364e, HIS19j, HIS302e, ILE257e, LEU217e, LEU359e, LYS20j, PRO21j, PRO22j, PRO23j, PRO357e, THR219e, THR220e, THR358e, TYR360e, VAL299e
• e-k: ALA178k, ALA180k, ALA186k, ALA190k, ALA285e, ALA293e, ALA372e, ARG187k, ARG270e, ARG373e, ASN182k, ASN281e, ASP250e, ASP283e, GLN224e, GLN252e, GLU269e, GLY251e, GLY286e, ILE282e, ILE313e, ILE369e, LEU179k, LEU183k, LEU188k, LEU267e, LEU349k, LYS181k, PHE265e, PHE370e, PRO185k, SER284e, THR184k, THR254e, TRP268e, VAL266e, VAL280e, VAL371e
• e-n: ALA178n, ALA180n, ASN182n, GLN224e, GLN252e, GLU174n, GLU269e, GLY175n, GLY223e, GLY251e, GLY255e, ILE253e, LEU179n, LEU183n, LEU267e, PHE265e, PRO222e, SER173n, SER176n, SER177n, THR172n, THR254e, VAL221e, VAL225e
• f-g: ALA175f, ALA177f, ARG193f, ARG208f, ARG254f, ARG256f, ARG265f, ASN181f, ASN266f, ASN267f, ASN29g, ASN34g, ASP202f, ASP259f, ASP26g, ASP40g, GLN173f, GLN183f, GLN189f, GLN196f, GLN42g, GLU188f, GLU191f, GLU210f, GLU229f, GLU239f, GLU245f, GLU24g, GLU252f, GLY178f, GLY238f, GLY258f, GLY263f, HIS199f, ILE195f, ILE223f, ILE243f, ILE255f, ILE37g, LEU171f, LEU257f, LYS170f, LYS172f, LYS180f, LYS20g, LYS251f, LYS260f, LYS35g, PHE176f, PHE209f, PRO190f, PRO197f, PRO21g, PRO22g, PRO23g, PRO25g, PRO32g, PRO38g, SER187f, SER28g, THR174f, THR30g, THR36g, THR41g, TRP201f, TRP253f, TRP27g, TYR182f, TYR184f, TYR221f, VAL185f, VAL198f, VAL200f, VAL237f, VAL261f, VAL262f, VAL264f, VAL31g, VAL33g, VAL39g
• f-h: ARG192h, GLN289f, GLY194h, ILE290f, PRO199h, VAL195h
• f-i: ALA213i, ALA215i, ALA225f, ALA250f, ALA270f, ALA275f, ALA277f, ARG193i, ARG205f, ARG241i, ARG256i, ARG273f, ARG287f, ASN203f, ASN214i, ASN240i, ASN242i, ASP259i, GLN196i, GLU191i, GLU216i, GLU239i, GLY227f, GLY238i, GLY258i, GLY272f, GLY274f, GLY279f, ILE195i, ILE223f, LEU217i, LEU257i, LYS228f, LYS251f, LYS260i, PHE206f, PHE211i, PHE269f, PRO212i, PRO218i, PRO271f, SER194i, SER224f, SER226f, THR230f, THR248f, THR278f, THR280f, TYR204f, VAL198i, VAL249f, VAL276f
• h-i: ALA175i, ALA197h, ALA225i, ALA236h, ALA275i, ALA277i, ALA281i, ALA366h, ALA384h, ARG205i, ARG208i, ARG241h, ARG254i, ARG256i, ARG286i, ARG287i, ASN198h, ASN233i, ASN273h, ASN288h, ASN386h, ASP232h, ASP237h, ASP244h, ASP276h, ASP284i, ASP361h, ASP365h, ASP385h, CYS211h, GLN169i, GLN173i, GLN231h, GLN275h, GLN289i, GLN362h, GLU229i, GLU245i, GLU247i, GLY206h, GLY212h, GLY227i, GLY238h, GLY272i, GLY277h, GLY279i, GLY291h, GLY364h, GLY379h, HIS235i, ILE167i, ILE209h, ILE223i, ILE243h, ILE279h, ILE290i, ILE295h, ILE369h, LEU171i, LEU201h, LEU231i, LEU239h, LEU242h, LEU290h, LEU383h, LYS164i, LYS165i, LYS170i, LYS172i, LYS207h, LYS228i, LYS245h, PHE176i, PHE206i, PHE269i, PHE370h, PHE377h, PRO199h, PRO204h, PRO210h, PRO232i, PRO271i, PRO283i, PRO296h, SER200h, SER224i, SER226i, SER230h, SER234i, SER235h, SER282i, SER289h, SER292h, SER368h, SER378h, THR168i, THR174i, THR230i, THR248i, THR278h, THR278i, THR280i, THR287h, THR382h, TYR221i, TYR234h, TYR381h, VAL203h, VAL220i, VAL233h, VAL236i, VAL237i, VAL240h, VAL249i, VAL276i, VAL285i, VAL288i, VAL367h, VAL371h, VAL380h
• h-j: ARG263h, HIS19j, LEU290h, PRO21j, PRO22j
• h-k: ALA178h, ALA178k, ALA180h, ALA180k, ALA186h, ALA186k, ALA190k, ALA193k, ALA197k, ALA236k, ALA262k, ALA285h, ALA285k, ALA293k, ALA301h, ALA301k, ALA310h, ALA310k, ALA345h, ALA345k, ALA348h, ALA348k, ALA372h, ALA372k, ARG187h, ARG187k, ARG192k, ARG228h, ARG263k, ARG270h, ARG272h, ARG306h, ARG306k, ARG308h, ARG308k, ARG350h, ARG350k, ARG373h, ARG373k, ASN182h, ASN198h, ASN273h, ASN281h, ASN288k, ASP218h, ASP237k, ASP250h, ASP259k, ASP274h, ASP276h, ASP283h, ASP283k, ASP300h, ASP300k, ASP318h, ASP318k, ASP361h, ASP374h, ASP374k, ASP376h, CYS227h, GLN224h, GLN252h, GLN261k, GLN275h, GLN343h, GLN343k, GLN362h, GLN363h, GLU171k, GLU174k, GLU216h, GLU269h, GLU305h, GLU347h, GLU347k, GLY175k, GLY194k, GLY206k, GLY214h, GLY223h, GLY238k, GLY251h, GLY256k, GLY260k, GLY277h, GLY286k, GLY291k, GLY294k, GLY309h, GLY342h, GLY364h, GLY379h, HIS302h, HIS302k, ILE243h, ILE253h, ILE257k, ILE271h, ILE279h, ILE282h, ILE295k, ILE311h, ILE311k, ILE313h, ILE355h, LEU179h, LEU179k, LEU183h, LEU183k, LEU188h, LEU188k, LEU201h, LEU217h, LEU239k, LEU242h, LEU290k, LEU307h, LEU307k, LEU315h, LEU315k, LEU320h, LEU344h, LEU344k, LEU349h, LEU349k, LEU359h, LEU359k, LEU375h, LEU375k, LYS181h, LYS181k, LYS189h, LYS189k, LYS205h, LYS205k, LYS207k, LYS258k, PHE265k, PHE316h, PHE370h, PHE370k, PHE377h, PRO185h, PRO185k, PRO199k, PRO204h, PRO204k, PRO222h, PRO296k, PRO356h, PRO356k, PRO357h, PRO357k, SER173k, SER176k, SER177h, SER177k, SER191h, SER191k, SER226h, SER235k, SER284h, SER284k, SER289k, SER292k, SER314h, SER314k, SER317h, SER317k, SER346h, SER346k, SER351h, SER351k, SER354h, SER368k, SER378h, THR172k, THR184h, THR184k, THR202h, THR202k, THR215h, THR219h, THR220h, THR278h, THR287k, THR319h, THR319k, THR321k, THR358h, THR358k, TRP248h, TRP268h, TRP304h, TRP304k, TYR234k, TYR352h, TYR352k, TYR360h, TYR381h, VAL195k, VAL203h, VAL203k, VAL221h, VAL225h, VAL249h, VAL264k, VAL266k, VAL280h, VAL299k, VAL371h, VAL371k, VAL380h
• h-l: ALA213l, ALA215l, ALA366h, ARG228h, ARG241h, ARG241l, ARG254l, ARG256l, ARG272h, ASN214l, ASN233l, ASN240l, ASN242l, ASN273h, ASP232h, ASP244h, ASP259l, ASP274h, ASP276h, ASP361h, ASP365h, CYS211h, CYS227h, GLN169l, GLN173l, GLN219l, GLN231h, GLN275h, GLN362h, GLN363h, GLU216h, GLU216l, GLU229l, GLU239l, GLU245l, GLU247l, GLY212h, GLY214h, GLY238l, GLY246h, GLY258l, GLY364h, HIS235l, ILE195l, ILE223l, ILE243h, ILE243l, ILE244l, ILE255l, LEU217l, LEU231l, LEU257l, LYS245h, LYS260l, PHE209l, PHE211l, PRO210h, PRO212l, PRO218l, PRO232l, SER226h, SER230h, SER234l, SER247h, SER289h, THR213h, THR215h, THR230l, TRP248h, TYR221l, TYR234h, VAL220l, VAL225h, VAL229h, VAL233h, VAL236l, VAL237l, VAL246l, VAL261l, VAL367h
• h-m: ALA301h, ASP218h, ASP300h, ASP361h, ASP365h, GLN298h, GLN362h, GLN363h, GLU216h, GLU24m, GLY18m, GLY297h, GLY364h, HIS19m, HIS302h, ILE257h, LEU217h, LEU359h, LYS20m, PRO21m, PRO22m, PRO23m, PRO357h, THR219h, THR220h, THR358h, TYR360h, VAL299h
• h-n: ALA180n, ALA186h, ALA186n, ALA190n, ALA285h, ALA293h, ALA372h, ARG187n, ARG270h, ARG373h, ASN182n, ASN281h, ASP169n, ASP250h, ASP283h, GLN224h, GLN252h, GLN343h, GLU269h, GLY251h, GLY286h, GLY342n, ILE282h, ILE313h, ILE369h, LEU179n, LEU183n, LEU188n, LEU267h, LEU349n, LYS181n, PHE265h, PHE370h, PRO185n, SER284h, THR184n, THR254h, TRP268h, VAL266h, VAL280h, VAL371h
• i-j: ALA175i, ALA177i, ARG193i, ARG208i, ARG254i, ARG256i, ARG265i, ASN181i, ASN266i, ASN267i, ASN29j, ASN34j, ASP202i, ASP259i, ASP26j, ASP40j, GLN173i, GLN183i, GLN189i, GLN196i, GLN42j, GLU188i, GLU191i, GLU210i, GLU229i, GLU239i, GLU245i, GLU24j, GLU252i, GLY178i, GLY238i, GLY258i, GLY263i, HIS199i, ILE223i, ILE243i, ILE255i, ILE37j, LEU257i, LYS170i, LYS172i, LYS180i, LYS20j, LYS251i, LYS260i, LYS35j, PHE176i, PHE209i, PRO190i, PRO197i, PRO21j, PRO22j, PRO23j, PRO25j, PRO32j, PRO38j, SER187i, SER28j, THR174i, THR30j, THR36j, THR41j, TRP201i, TRP253i, TRP27j, TYR182i, TYR184i, VAL185i, VAL198i, VAL200i, VAL237i, VAL261i, VAL262i, VAL264i, VAL31j, VAL33j, VAL39j
• i-k: ARG192k, GLN289i, GLY194k, ILE290i, PRO199k, VAL195k
• i-l: ALA213l, ALA215l, ALA225i, ALA250i, ALA270i, ALA275i, ALA277i, ARG193l, ARG205i, ARG241l, ARG256l, ARG273i, ARG287i, ASN203i, ASN214l, ASN240l, ASN242l, ASP259l, GLN196l, GLU191l, GLU216l, GLU239l, GLY227i, GLY238l, GLY258l, GLY272i, GLY274i, GLY279i, ILE195l, ILE223i, LEU217l, LEU257l, LYS228i, LYS251i, LYS260l, PHE206i, PHE211l, PHE269i, PRO212l, PRO218l, PRO271i, SER194l, SER224i, SER226i, THR230i, THR248i, THR278i, THR280i, TYR204i, VAL198l, VAL249i, VAL276i
• k-l: ALA175l, ALA197k, ALA225l, ALA236k, ALA275l, ALA277l, ALA281l, ALA366k, ALA384k, ARG205l, ARG208l, ARG241k, ARG254l, ARG256l, ARG286l, ARG287l, ASN198k, ASN233l, ASN273k, ASN288k, ASN386k, ASP232k, ASP237k, ASP244k, ASP276k, ASP284l, ASP361k, ASP365k, ASP385k, CYS211k, GLN169l, GLN173l, GLN231k, GLN275k, GLN289l, GLN362k, GLU229l, GLU245l, GLU247l, GLY206k, GLY212k, GLY227l, GLY238k, GLY272l, GLY277k, GLY279l, GLY291k, GLY364k, GLY379k, HIS235l, ILE167l, ILE209k, ILE223l, ILE243k, ILE279k, ILE290l, ILE295k, ILE369k, LEU171l, LEU201k, LEU231l, LEU239k, LEU242k, LEU290k, LEU383k, LYS164l, LYS165l, LYS170l, LYS172l, LYS207k, LYS228l, LYS245k, PHE176l, PHE206l, PHE269l, PHE370k, PHE377k, PRO199k, PRO204k, PRO210k, PRO232l, PRO271l, PRO283l, PRO296k, SER200k, SER224l, SER226l, SER230k, SER234l, SER235k, SER247k, SER282l, SER289k, SER292k, SER368k, SER378k, THR168l, THR174l, THR230l, THR248l, THR278k, THR278l, THR280l, THR287k, THR382k, TYR221l, TYR234k, TYR381k, VAL203k, VAL220l, VAL233k, VAL236l, VAL237l, VAL240k, VAL249l, VAL276l, VAL285l, VAL288l, VAL367k, VAL371k, VAL380k
• k-m: ARG263k, GLN42m, HIS19m, LEU239k, LEU290k, PRO21m, PRO22m
• k-n: ALA178k, ALA178n, ALA180k, ALA180n, ALA186k, ALA186n, ALA190n, ALA193n, ALA197n, ALA236n, ALA262n, ALA285k, ALA285n, ALA293n, ALA301k, ALA301n, ALA310k, ALA310n, ALA322k, ALA345k, ALA345n, ALA348k, ALA348n, ALA372k, ALA372n, ARG187k, ARG187n, ARG192n, ARG228k, ARG263n, ARG270k, ARG272k, ARG306k, ARG306n, ARG308k, ARG308n, ARG350k, ARG350n, ARG373k, ARG373n, ASN170n, ASN182k, ASN182n, ASN198k, ASN273k, ASN281k, ASN288n, ASP169n, ASP218k, ASP237n, ASP250k, ASP259n, ASP274k, ASP276k, ASP283k, ASP283n, ASP300k, ASP300n, ASP318k, ASP318n, ASP361k, ASP374k, ASP374n, ASP376k, CYS227k, GLN224k, GLN252k, GLN261n, GLN275k, GLN343k, GLN362k, GLN363k, GLU171n, GLU174n, GLU216k, GLU269k, GLU305k, GLU347k, GLU347n, GLY175n, GLY194n, GLY206n, GLY214k, GLY223k, GLY238n, GLY251k, GLY256n, GLY260n, GLY277k, GLY286n, GLY291n, GLY294n, GLY309k, GLY342n, GLY364k, GLY379k, HIS302k, HIS302n, ILE243k, ILE253k, ILE257n, ILE271k, ILE279k, ILE282k, ILE295n, ILE311k, ILE311n, ILE313k, ILE313n, ILE355k, ILE369n, LEU179k, LEU179n, LEU183k, LEU183n, LEU188k, LEU188n, LEU201k, LEU217k, LEU239n, LEU242k, LEU290n, LEU307k, LEU307n, LEU315n, LEU320k, LEU344k, LEU344n, LEU349k, LEU349n, LEU359k, LEU359n, LEU375k, LEU375n, LYS181k, LYS181n, LYS189k, LYS189n, LYS205k, LYS205n, LYS207n, LYS258n, PHE265n, PHE316k, PHE316n, PHE370k, PHE370n, PHE377k, PRO185k, PRO185n, PRO199n, PRO204k, PRO204n, PRO222k, PRO296n, PRO356k, PRO356n, PRO357k, PRO357n, SER173n, SER176n, SER177k, SER177n, SER191k, SER191n, SER226k, SER235n, SER284k, SER284n, SER289n, SER292n, SER314k, SER314n, SER317k, SER317n, SER346k, SER346n, SER351k, SER351n, SER354k, SER368n, SER378k, THR172k, THR172n, THR184k, THR184n, THR202k, THR202n, THR215k, THR219k, THR220k, THR278k, THR287n, THR319k, THR319n, THR321k, THR358k, THR358n, TRP248k, TRP268k, TRP304k, TRP304n, TYR234n, TYR352k, TYR352n, TYR360k, TYR381k, VAL195n, VAL203k, VAL203n, VAL221k, VAL225k, VAL249k, VAL264n, VAL266n, VAL280k, VAL299n, VAL371k, VAL371n, VAL380k
• k-o: ALA213o, ALA215o, ALA366k, ARG228k, ARG241k, ARG241o, ARG254o, ARG256o, ARG272k, ASN214o, ASN233o, ASN240o, ASN242o, ASN273k, ASP232k, ASP244k, ASP259o, ASP274k, ASP276k, ASP361k, ASP365k, CYS211k, CYS227k, GLN169o, GLN173o, GLN219o, GLN231k, GLN275k, GLN362k, GLN363k, GLU216k, GLU216o, GLU229o, GLU239o, GLU245o, GLU247o, GLY212k, GLY214k, GLY238o, GLY246k, GLY258o, GLY364k, HIS235o, ILE195o, ILE223o, ILE243k, ILE243o, ILE244o, ILE255o, LEU217o, LEU231o, LEU257o, LYS228o, LYS245k, LYS260o, PHE209o, PHE211o, PRO210k, PRO212o, PRO218o, PRO232o, SER226k, SER230k, SER234o, SER247k, SER289k, THR213k, THR215k, THR230o, TRP248k, TYR221o, TYR234k, VAL220o, VAL225k, VAL229k, VAL233k, VAL236o, VAL237o, VAL246o, VAL261o, VAL367k
• k-p: ALA301k, ASP218k, ASP300k, ASP361k, ASP365k, GLN298k, GLN362k, GLN363k, GLU216k, GLU24p, GLY297k, GLY364k, HIS19p, HIS302k, ILE257k, LEU217k, LEU359k, LYS20p, PRO21p, PRO22p, PRO23p, PRO357k, THR219k, THR220k, THR358k, TYR360k, VAL299k
• l-m: ALA175l, ALA177l, ARG193l, ARG208l, ARG254l, ARG256l, ARG265l, ASN181l, ASN240l, ASN266l, ASN267l, ASN29m, ASN34m, ASP202l, ASP259l, ASP26m, ASP40m, GLN173l, GLN183l, GLN189l, GLN196l, GLN42m, GLU188l, GLU191l, GLU210l, GLU229l, GLU239l, GLU245l, GLU24m, GLU252l, GLY178l, GLY238l, GLY258l, GLY263l, HIS199l, HIS235l, ILE223l, ILE243l, ILE255l, ILE37m, LEU171l, LEU257l, LYS170l, LYS172l, LYS180l, LYS20m, LYS251l, LYS260l, LYS35m, PHE176l, PHE209l, PRO190l, PRO197l, PRO21m, PRO22m, PRO23m, PRO25m, PRO32m, PRO38m, SER187l, SER28m, THR174l, THR30m, THR36m, THR41m, TRP201l, TRP253l, TRP27m, TYR182l, TYR184l, TYR221l, VAL185l, VAL198l, VAL200l, VAL237l, VAL261l, VAL262l, VAL264l, VAL31m, VAL33m, VAL39m
• l-n: ARG192n, GLN289l, GLY194n, ILE290l, VAL195n
• l-o: ALA213o, ALA215o, ALA225l, ALA250l, ALA270l, ALA275l, ALA277l, ARG193o, ARG205l, ARG241o, ARG256o, ARG273l, ARG287l, ASN203l, ASN214o, ASN240o, ASN242o, ASP259o, GLN196o, GLU191o, GLU216o, GLU239o, GLY227l, GLY238o, GLY258o, GLY272l, GLY274l, GLY279l, ILE195o, ILE223l, LEU217o, LEU257o, LYS228l, LYS251l, LYS260o, PHE206l, PHE211o, PHE269l, PRO212o, PRO218o, PRO271l, SER194o, SER224l, SER226l, THR230l, THR248l, THR278l, THR280l, TYR204l, VAL198o, VAL249l, VAL276l
• n-o: ALA175o, ALA197n, ALA225o, ALA236n, ALA275o, ALA277o, ALA281o, ALA366n, ALA384n, ARG205o, ARG208o, ARG241n, ARG254o, ARG256o, ARG286o, ARG287o, ASN198n, ASN233o, ASN273n, ASN288n, ASN386n, ASP232n, ASP237n, ASP244n, ASP276n, ASP284o, ASP361n, ASP365n, ASP385n, CYS211n, GLN169o, GLN173o, GLN231n, GLN275n, GLN289o, GLN362n, GLU229o, GLU245o, GLU247o, GLY206n, GLY227o, GLY238n, GLY272o, GLY277n, GLY279o, GLY291n, GLY364n, GLY379n, HIS235o, ILE167o, ILE209n, ILE223o, ILE243n, ILE279n, ILE290o, ILE295n, LEU171o, LEU201n, LEU231o, LEU239n, LEU242n, LEU290n, LEU383n, LYS164o, LYS165o, LYS170o, LYS172o, LYS207n, LYS228o, LYS245n, PHE176o, PHE206o, PHE269o, PHE370n, PHE377n, PRO199n, PRO204n, PRO210n, PRO232o, PRO271o, PRO283o, PRO296n, SER200n, SER224o, SER226o, SER230n, SER234o, SER235n, SER247n, SER282o, SER289n, SER292n, SER368n, SER378n, THR168o, THR174o, THR230o, THR248o, THR278n, THR278o, THR280o, THR287n, THR382n, TYR221o, TYR234n, TYR381n, VAL203n, VAL233n, VAL236o, VAL237o, VAL240n, VAL249o, VAL276o, VAL285o, VAL288o, VAL367n, VAL371n, VAL380n
• n-p: ARG263n, HIS19p, LEU290n, PRO21p, PRO22p
• o-p: ALA175o, ALA177o, ARG193o, ARG208o, ARG254o, ARG256o, ARG265o, ASN181o, ASN266o, ASN267o, ASN29p, ASN34p, ASP202o, ASP259o, ASP26p, ASP40p, GLN173o, GLN183o, GLN189o, GLN196o, GLU188o, GLU191o, GLU210o, GLU229o, GLU239o, GLU245o, GLU24p, GLU252o, GLY178o, GLY238o, GLY258o, GLY263o, HIS199o, ILE223o, ILE243o, ILE255o, ILE37p, LEU257o, LYS180o, LYS20p, LYS251o, LYS260o, LYS35p, PHE176o, PHE209o, PRO190o, PRO197o, PRO21p, PRO22p, PRO23p, PRO25p, PRO32p, PRO38p, SER187o, SER28p, THR174o, THR30p, THR36p, THR41p, TRP201o, TRP253o, TRP27p, TYR182o, TYR184o, TYR221o, VAL185o, VAL198o, VAL200o, VAL237o, VAL261o, VAL262o, VAL264o, VAL31p, VAL33p, VAL39p