3J0S

remodeling of actin filaments by adf cofilin proteins

• Total interactions analyzed: 276
• Total true interactions: 43
• Strongest Interaction:
  • Chains: B-O
  • Int. Res.: 116
  • Norm. En. per Res.: -2.5042
• Hub Node: A(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-4.3774	-14.7834	-74.3903	-93.5511	94	7	0	4595	0	32	24
A-C	-7.0518	-8.3399	-25.9659	-41.3575	50	9	2	2931	1	18	13
A-M	-33.7209	-2.3895	-254.234	-290.3444	116	32	4	11585	3	37	20
A-N	-17.2654	-68.5802	-126.528	-212.3736	97	11	1	6663	3	54	57
B-C	-4.3631	-14.7813	-74.3937	-93.5381	94	7	0	4595	0	32	24
B-D	-7.065	-8.3278	-25.9266	-41.3195	50	9	2	2932	1	18	13
B-O	-33.7819	-2.4184	-254.29	-290.4903	116	32	4	11584	3	37	20
B-Q	-17.2551	-68.5571	-126.502	-212.3142	97	11	1	6664	3	54	57
C-D	-4.3749	-14.7845	-74.341	-93.5004	94	7	0	4593	0	32	24
C-E	-7.0774	-8.331	-25.9954	-41.4039	50	9	2	2930	1	18	13
C-N	-33.6977	-2.3789	-254.15	-290.2266	116	32	4	11581	3	37	20
C-P	-17.2631	-68.5724	-126.443	-212.2785	97	11	1	6663	3	54	57
D-E	-4.3804	-14.7845	-74.3316	-93.4966	94	7	0	4593	0	32	24
D-F	-7.0734	-8.3395	-25.9523	-41.3652	50	9	2	2933	1	18	13
D-Q	-33.7384	-2.3911	-254.133	-290.2625	116	33	4	11582	3	37	20
D-S	-17.2612	-68.5842	-126.626	-212.4714	97	11	1	6661	3	54	57
E-F	-4.3866	-14.7868	-74.3811	-93.5545	94	7	0	4594	0	32	24
E-G	-7.0603	-8.3365	-26.1473	-41.5441	50	8	2	2933	1	18	13
E-P	-33.7531	-2.392	-254.303	-290.4481	116	33	4	11586	3	37	20
E-R	-17.2542	-68.5758	-126.522	-212.352	97	11	1	6663	3	54	57
F-G	-4.3752	-14.7837	-74.3741	-93.533	94	7	0	4592	0	32	24
F-H	-7.0869	-8.3343	-26.05	-41.4713	50	9	2	2931	1	18	13
F-S	-33.7144	-2.3963	-254.24	-290.3507	116	32	4	11584	3	37	20
F-U	-17.2528	-68.5699	-126.489	-212.3117	97	11	1	6662	3	54	57
G-H	-4.3755	-14.7833	-74.3479	-93.5067	94	7	0	4594	0	32	24
G-I	-7.0374	-8.3316	-26.0494	-41.4185	50	9	2	2931	1	18	13
G-R	-33.7708	-2.3863	-254.255	-290.4121	116	32	4	11584	3	37	20
G-T	-17.2508	-68.5902	-126.464	-212.3049	97	11	1	6661	3	54	57
H-I	-4.3748	-14.7861	-74.3481	-93.509	94	7	0	4596	0	32	24
H-J	-7.0675	-8.3388	-25.8799	-41.2861	50	9	2	2932	1	18	13
H-U	-33.7073	-2.3905	-254.298	-290.3958	116	32	4	11588	3	37	20
H-W	-17.2416	-68.5824	-126.618	-212.442	97	11	1	6662	3	54	57
I-J	-4.3836	-14.7872	-74.3346	-93.5055	94	7	0	4594	0	32	24
I-K	-7.0609	-8.3374	-25.9424	-41.3407	50	9	2	2932	1	18	13
I-T	-33.7617	-2.3877	-254.332	-290.4814	116	32	4	11585	3	37	20
I-V	-17.2742	-68.5631	-126.542	-212.3793	97	11	1	6660	3	54	57
J-K	-4.3749	-14.7855	-74.3441	-93.5044	94	7	0	4594	0	32	24
J-L	-7.046	-8.3381	-25.9125	-41.2966	50	9	2	2933	1	18	13
J-W	-33.7173	-2.3814	-254.174	-290.2727	116	33	4	11583	3	37	20
J-X	-17.2648	-68.5679	-42.3707	-128.2034	52	8	1	2589	1	16	16
K-L	-4.3794	-14.7852	-74.3567	-93.5213	94	7	0	4595	0	32	24
K-V	-33.7726	-2.3955	-254.297	-290.4651	116	32	4	11584	3	37	20
L-X	-33.7107	-2.4047	-87.0918	-123.2072	67	4	1	3962	0	3	1

Interface residues

• A-B: ALA114B, ALA170B, ALA174B, ALA204A, ALA231A, ARG177B, ARG196A, ARG256A, ARG256B, ARG312B, ARG39A, ARG62A, ASN111B, ASN115B, ASN252A, ASN280B, ASP179B, ASP184A, ASP187A, CYS272B, GLN263B, GLN41A, GLU117B, GLU195A, GLU224B, GLU259B, GLU270A, GLU270B, GLU276B, GLU72B, GLY197A, GLY268A, GLY268B, GLY273B, GLY42A, GLY63A, HIS161B, HIS173B, HIS275B, HIS40A, HIS73A, HIS73B, ILE175B, ILE192A, ILE274B, ILE64A, ILE75B, LEU110B, LEU171B, LEU176B, LEU178B, LEU180B, LEU193A, LEU261B, LEU267A, LEU320B, LEU65A, LYS113B, LYS191A, LYS284B, LYS61A, MET190A, MET227A, MET227B, MET269A, MET269B, MET44A, PHE200A, PHE223B, PHE262B, PHE266A, PHE266B, PRO109B, PRO112B, PRO172B, PRO264A, PRO264B, SER199A, SER265A, SER265B, SER271B, SER60A, THR194A, THR201A, THR202A, THR203A, THR277B, THR77B, TYR169B, TYR188A, TYR198A, TYR69A, VAL43A, VAL76B
• A-C: ALA204A, ALA321C, ARG116C, ARG290C, ARG372C, ASP244A, ASP286C, ASP288C, ASP292C, CYS285C, CYS374C, GLN246A, GLN41A, GLN49A, GLU167C, GLU205A, GLU207A, GLU241A, GLY245A, GLY46A, GLY48A, HIS371C, ILE208A, ILE248A, ILE282C, ILE289C, LEU242A, LYS113C, LYS291C, LYS373C, LYS61A, MET283C, MET325C, MET44A, MET47A, PHE375C, PRO243A, PRO322C, SER199A, SER323C, SER60A, THR202A, THR324C, TYR166C, TYR169C, TYR294C, VAL287C, VAL370C, VAL43A, VAL45A
• A-M: ALA105M, ALA109M, ALA118M, ALA123M, ALA135A, ALA137M, ALA144A, ALA26A, ALA295A, ALA2M, ALA331A, ALA347A, ALA6M, ARG147A, ARG335A, ASN138M, ASN296A, ASN46M, ASP122M, ASP145M, ASP24A, ASP25A, ASP288A, ASP292A, ASP43M, CYS139M, CYS147M, CYS374A, CYS80M, GLN136M, GLN137A, GLN354A, GLU107A, GLU107M, GLU134M, GLU141M, GLU142M, GLU151M, GLU167A, GLU334A, GLY130M, GLY146A, GLY154M, GLY168A, GLY23A, GLY342A, GLY343A, GLY4M, ILE116M, ILE124M, ILE131M, ILE136A, ILE165A, ILE329A, ILE330A, ILE341A, ILE345A, ILE47M, LEU104A, LEU111M, LEU140A, LEU142A, LEU346A, LEU349A, LEU40M, LYS112M, LYS114M, LYS121M, LYS125M, LYS126M, LYS152M, LYS291A, LYS326A, LYS328A, LYS373A, LYS44M, LYS45M, MET115M, MET1M, MET355A, PHE103M, PHE352A, PHE375A, PRO106M, PRO332A, PRO333A, SER108M, SER113M, SER119M, SER120M, SER141A, SER145A, SER338A, SER344A, SER348A, SER350A, SER3M, THR148A, THR148M, THR149A, THR351A, TRP104M, TRP340A, TYR117M, TYR133A, TYR143A, TYR166A, TYR169A, TYR337A, TYR82M, VAL134A, VAL139A, VAL298A, VAL339A, VAL5M, VAL7M
• A-N: ALA157N, ALA19A, ALA26A, ALA29A, ALA35N, ALA87N, ALA97A, ARG210A, ARG21N, ARG28A, ARG32N, ARG95A, ASN16N, ASN92A, ASP17N, ASP211A, ASP24A, ASP25A, ASP2A, ASP3A, ASP51A, ASP56A, ASP86N, ASP98N, GLN49A, GLU100A, GLU151N, GLU214A, GLU241A, GLU57A, GLU90N, GLU93A, GLU93N, GLU97N, GLU99A, GLY130N, GLY154N, GLY155N, GLY20A, GLY55A, HIS101A, HIS133N, HIS87A, HIS88A, ILE131N, LEU153N, LEU84N, LEU8A, LEU94A, LEU99N, LYS125N, LYS132N, LYS18A, LYS19N, LYS215A, LYS22N, LYS336A, LYS33N, LYS34N, LYS50A, LYS61A, LYS92N, LYS95N, LYS96N, MET18N, MET305A, PHE15N, PHE21A, PHE31A, PHE90A, PRO243A, PRO26N, PRO27A, PRO98A, SER156N, SER23N, SER24N, SER94N, THR129N, THR25N, THR88N, THR91N, TRP340A, TYR240A, TYR337A, TYR53A, TYR85N, TYR89N, TYR91A, VAL100N, VAL20N, VAL29N, VAL30A, VAL36N, VAL54A, VAL57N, VAL96A
• B-C: ALA114C, ALA170C, ALA174C, ALA204B, ALA231B, ARG177C, ARG196B, ARG256B, ARG256C, ARG312C, ARG39B, ARG62B, ASN111C, ASN115C, ASN252B, ASN280C, ASP179C, ASP184B, ASP187B, CYS272C, GLN263C, GLN41B, GLU117C, GLU195B, GLU224C, GLU259C, GLU270B, GLU270C, GLU276C, GLU72C, GLY197B, GLY268B, GLY268C, GLY273C, GLY42B, GLY63B, HIS161C, HIS173C, HIS275C, HIS40B, HIS73B, HIS73C, ILE175C, ILE192B, ILE274C, ILE64B, ILE75C, LEU110C, LEU171C, LEU176C, LEU178C, LEU180C, LEU193B, LEU261C, LEU267B, LEU320C, LEU65B, LYS113C, LYS191B, LYS284C, LYS61B, MET190B, MET227B, MET227C, MET269B, MET269C, MET44B, PHE200B, PHE223C, PHE262C, PHE266B, PHE266C, PRO109C, PRO112C, PRO172C, PRO264B, PRO264C, SER199B, SER265B, SER265C, SER271C, SER60B, THR194B, THR201B, THR202B, THR203B, THR277C, THR77C, TYR169C, TYR188B, TYR198B, TYR69B, VAL43B, VAL76C
• B-D: ALA204B, ALA321D, ARG116D, ARG290D, ARG372D, ASP244B, ASP286D, ASP288D, ASP292D, CYS285D, CYS374D, GLN246B, GLN41B, GLN49B, GLU167D, GLU205B, GLU207B, GLU241B, GLY245B, GLY46B, GLY48B, HIS371D, ILE208B, ILE248B, ILE282D, ILE289D, LEU242B, LYS113D, LYS291D, LYS373D, LYS61B, MET283D, MET325D, MET44B, MET47B, PHE375D, PRO243B, PRO322D, SER199B, SER323D, SER60B, THR202B, THR324D, TYR166D, TYR169D, TYR294D, VAL287D, VAL370D, VAL43B, VAL45B
• B-O: ALA105O, ALA109O, ALA118O, ALA123O, ALA135B, ALA137O, ALA144B, ALA26B, ALA295B, ALA2O, ALA331B, ALA347B, ALA6O, ARG147B, ARG335B, ASN138O, ASN296B, ASN46O, ASP122O, ASP145O, ASP24B, ASP25B, ASP288B, ASP292B, ASP43O, CYS139O, CYS147O, CYS374B, CYS80O, GLN136O, GLN137B, GLN354B, GLU107B, GLU107O, GLU134O, GLU141O, GLU142O, GLU151O, GLU167B, GLU334B, GLY130O, GLY146B, GLY154O, GLY168B, GLY23B, GLY342B, GLY343B, GLY4O, ILE116O, ILE124O, ILE131O, ILE136B, ILE165B, ILE329B, ILE330B, ILE341B, ILE345B, ILE47O, LEU104B, LEU111O, LEU140B, LEU142B, LEU346B, LEU349B, LEU40O, LYS112O, LYS114O, LYS121O, LYS125O, LYS126O, LYS152O, LYS291B, LYS326B, LYS328B, LYS373B, LYS44O, LYS45O, MET115O, MET1O, MET355B, PHE103O, PHE352B, PHE375B, PRO106O, PRO332B, PRO333B, SER108O, SER113O, SER119O, SER120O, SER141B, SER145B, SER338B, SER344B, SER348B, SER350B, SER3O, THR148B, THR148O, THR149B, THR351B, TRP104O, TRP340B, TYR117O, TYR133B, TYR143B, TYR166B, TYR169B, TYR337B, TYR82O, VAL134B, VAL139B, VAL298B, VAL339B, VAL5O, VAL7O
• B-Q: ALA157Q, ALA19B, ALA26B, ALA29B, ALA35Q, ALA87Q, ALA97B, ARG210B, ARG21Q, ARG28B, ARG32Q, ARG95B, ASN16Q, ASN92B, ASP17Q, ASP211B, ASP24B, ASP25B, ASP2B, ASP3B, ASP51B, ASP56B, ASP86Q, ASP98Q, GLN49B, GLU100B, GLU151Q, GLU214B, GLU241B, GLU57B, GLU90Q, GLU93B, GLU93Q, GLU97Q, GLU99B, GLY130Q, GLY154Q, GLY155Q, GLY20B, GLY55B, HIS101B, HIS133Q, HIS87B, HIS88B, ILE131Q, LEU153Q, LEU84Q, LEU8B, LEU94B, LEU99Q, LYS125Q, LYS132Q, LYS18B, LYS19Q, LYS215B, LYS22Q, LYS336B, LYS33Q, LYS34Q, LYS50B, LYS61B, LYS92Q, LYS95Q, LYS96Q, MET18Q, MET305B, PHE15Q, PHE21B, PHE31B, PHE90B, PRO243B, PRO26Q, PRO27B, PRO98B, SER156Q, SER23Q, SER24Q, SER94Q, THR129Q, THR25Q, THR88Q, THR91Q, TRP340B, TYR240B, TYR337B, TYR53B, TYR85Q, TYR89Q, TYR91B, VAL100Q, VAL20Q, VAL29Q, VAL30B, VAL36Q, VAL54B, VAL57Q, VAL96B
• C-D: ALA114D, ALA170D, ALA174D, ALA204C, ALA231C, ARG177D, ARG196C, ARG256C, ARG256D, ARG312D, ARG39C, ARG62C, ASN111D, ASN115D, ASN252C, ASN280D, ASP179D, ASP184C, ASP187C, CYS272D, GLN263D, GLN41C, GLU117D, GLU195C, GLU224D, GLU259D, GLU270C, GLU270D, GLU276D, GLU72D, GLY197C, GLY268C, GLY268D, GLY273D, GLY42C, GLY63C, HIS161D, HIS173D, HIS275D, HIS40C, HIS73C, HIS73D, ILE175D, ILE192C, ILE274D, ILE64C, ILE75D, LEU110D, LEU171D, LEU176D, LEU178D, LEU180D, LEU193C, LEU261D, LEU267C, LEU320D, LEU65C, LYS113D, LYS191C, LYS284D, LYS61C, MET190C, MET227C, MET227D, MET269C, MET269D, MET44C, PHE200C, PHE223D, PHE262D, PHE266C, PHE266D, PRO109D, PRO112D, PRO172D, PRO264C, PRO264D, SER199C, SER265C, SER265D, SER271D, SER60C, THR194C, THR201C, THR202C, THR203C, THR277D, THR77D, TYR169D, TYR188C, TYR198C, TYR69C, VAL43C, VAL76D
• C-E: ALA204C, ALA321E, ARG116E, ARG290E, ARG372E, ASP244C, ASP286E, ASP288E, ASP292E, CYS285E, CYS374E, GLN246C, GLN41C, GLN49C, GLU167E, GLU205C, GLU207C, GLU241C, GLY245C, GLY46C, GLY48C, HIS371E, ILE208C, ILE248C, ILE282E, ILE289E, LEU242C, LYS113E, LYS291E, LYS373E, LYS61C, MET283E, MET325E, MET44C, MET47C, PHE375E, PRO243C, PRO322E, SER199C, SER323E, SER60C, THR202C, THR324E, TYR166E, TYR169E, TYR294E, VAL287E, VAL370E, VAL43C, VAL45C
• C-N: ALA105N, ALA109N, ALA118N, ALA123N, ALA135C, ALA137N, ALA144C, ALA26C, ALA295C, ALA2N, ALA331C, ALA347C, ALA6N, ARG147C, ARG335C, ASN138N, ASN296C, ASN46N, ASP122N, ASP145N, ASP24C, ASP25C, ASP288C, ASP292C, ASP43N, CYS139N, CYS147N, CYS374C, CYS80N, GLN136N, GLN137C, GLN354C, GLU107C, GLU107N, GLU134N, GLU141N, GLU142N, GLU151N, GLU167C, GLU334C, GLY130N, GLY146C, GLY154N, GLY168C, GLY23C, GLY342C, GLY343C, GLY4N, ILE116N, ILE124N, ILE131N, ILE136C, ILE165C, ILE329C, ILE330C, ILE341C, ILE345C, ILE47N, LEU104C, LEU111N, LEU140C, LEU142C, LEU346C, LEU349C, LEU40N, LYS112N, LYS114N, LYS121N, LYS125N, LYS126N, LYS152N, LYS291C, LYS326C, LYS328C, LYS373C, LYS44N, LYS45N, MET115N, MET1N, MET355C, PHE103N, PHE352C, PHE375C, PRO106N, PRO332C, PRO333C, SER108N, SER113N, SER119N, SER120N, SER141C, SER145C, SER338C, SER344C, SER348C, SER350C, SER3N, THR148C, THR148N, THR149C, THR351C, TRP104N, TRP340C, TYR117N, TYR133C, TYR143C, TYR166C, TYR169C, TYR337C, TYR82N, VAL134C, VAL139C, VAL298C, VAL339C, VAL5N, VAL7N
• C-P: ALA157P, ALA19C, ALA26C, ALA29C, ALA35P, ALA87P, ALA97C, ARG210C, ARG21P, ARG28C, ARG32P, ARG95C, ASN16P, ASN92C, ASP17P, ASP211C, ASP24C, ASP25C, ASP2C, ASP3C, ASP51C, ASP56C, ASP86P, ASP98P, GLN49C, GLU100C, GLU151P, GLU214C, GLU241C, GLU57C, GLU90P, GLU93C, GLU93P, GLU97P, GLU99C, GLY130P, GLY154P, GLY155P, GLY20C, GLY55C, HIS101C, HIS133P, HIS87C, HIS88C, ILE131P, LEU153P, LEU84P, LEU8C, LEU94C, LEU99P, LYS125P, LYS132P, LYS18C, LYS19P, LYS215C, LYS22P, LYS336C, LYS33P, LYS34P, LYS50C, LYS61C, LYS92P, LYS95P, LYS96P, MET18P, MET305C, PHE15P, PHE21C, PHE31C, PHE90C, PRO243C, PRO26P, PRO27C, PRO98C, SER156P, SER23P, SER24P, SER94P, THR129P, THR25P, THR88P, THR91P, TRP340C, TYR240C, TYR337C, TYR53C, TYR85P, TYR89P, TYR91C, VAL100P, VAL20P, VAL29P, VAL30C, VAL36P, VAL54C, VAL57P, VAL96C
• D-E: ALA114E, ALA170E, ALA174E, ALA204D, ALA231D, ARG177E, ARG196D, ARG256D, ARG256E, ARG312E, ARG39D, ARG62D, ASN111E, ASN115E, ASN252D, ASN280E, ASP179E, ASP184D, ASP187D, CYS272E, GLN263E, GLN41D, GLU117E, GLU195D, GLU224E, GLU259E, GLU270D, GLU270E, GLU276E, GLU72E, GLY197D, GLY268D, GLY268E, GLY273E, GLY42D, GLY63D, HIS161E, HIS173E, HIS275E, HIS40D, HIS73D, HIS73E, ILE175E, ILE192D, ILE274E, ILE64D, ILE75E, LEU110E, LEU171E, LEU176E, LEU178E, LEU180E, LEU193D, LEU261E, LEU267D, LEU320E, LEU65D, LYS113E, LYS191D, LYS284E, LYS61D, MET190D, MET227D, MET227E, MET269D, MET269E, MET44D, PHE200D, PHE223E, PHE262E, PHE266D, PHE266E, PRO109E, PRO112E, PRO172E, PRO264D, PRO264E, SER199D, SER265D, SER265E, SER271E, SER60D, THR194D, THR201D, THR202D, THR203D, THR277E, THR77E, TYR169E, TYR188D, TYR198D, TYR69D, VAL43D, VAL76E
• D-F: ALA204D, ALA321F, ARG116F, ARG290F, ARG372F, ASP244D, ASP286F, ASP288F, ASP292F, CYS285F, CYS374F, GLN246D, GLN41D, GLN49D, GLU167F, GLU205D, GLU207D, GLU241D, GLY245D, GLY46D, GLY48D, HIS371F, ILE208D, ILE248D, ILE282F, ILE289F, LEU242D, LYS113F, LYS291F, LYS373F, LYS61D, MET283F, MET325F, MET44D, MET47D, PHE375F, PRO243D, PRO322F, SER199D, SER323F, SER60D, THR202D, THR324F, TYR166F, TYR169F, TYR294F, VAL287F, VAL370F, VAL43D, VAL45D
• D-Q: ALA105Q, ALA109Q, ALA118Q, ALA123Q, ALA135D, ALA137Q, ALA144D, ALA26D, ALA295D, ALA2Q, ALA331D, ALA347D, ALA6Q, ARG147D, ARG335D, ASN138Q, ASN296D, ASN46Q, ASP122Q, ASP145Q, ASP24D, ASP25D, ASP288D, ASP292D, ASP43Q, CYS139Q, CYS147Q, CYS374D, CYS80Q, GLN136Q, GLN137D, GLN354D, GLU107D, GLU107Q, GLU134Q, GLU141Q, GLU142Q, GLU151Q, GLU167D, GLU334D, GLY130Q, GLY146D, GLY154Q, GLY168D, GLY23D, GLY342D, GLY343D, GLY4Q, ILE116Q, ILE124Q, ILE131Q, ILE136D, ILE165D, ILE329D, ILE330D, ILE341D, ILE345D, ILE47Q, LEU104D, LEU111Q, LEU140D, LEU142D, LEU346D, LEU349D, LEU40Q, LYS112Q, LYS114Q, LYS121Q, LYS125Q, LYS126Q, LYS152Q, LYS291D, LYS326D, LYS328D, LYS373D, LYS44Q, LYS45Q, MET115Q, MET1Q, MET355D, PHE103Q, PHE352D, PHE375D, PRO106Q, PRO332D, PRO333D, SER108Q, SER113Q, SER119Q, SER120Q, SER141D, SER145D, SER338D, SER344D, SER348D, SER350D, SER3Q, THR148D, THR148Q, THR149D, THR351D, TRP104Q, TRP340D, TYR117Q, TYR133D, TYR143D, TYR166D, TYR169D, TYR337D, TYR82Q, VAL134D, VAL139D, VAL298D, VAL339D, VAL5Q, VAL7Q
• D-S: ALA157S, ALA19D, ALA26D, ALA29D, ALA35S, ALA87S, ALA97D, ARG210D, ARG21S, ARG28D, ARG32S, ARG95D, ASN16S, ASN92D, ASP17S, ASP211D, ASP24D, ASP25D, ASP2D, ASP3D, ASP51D, ASP56D, ASP86S, ASP98S, GLN49D, GLU100D, GLU151S, GLU214D, GLU241D, GLU57D, GLU90S, GLU93D, GLU93S, GLU97S, GLU99D, GLY130S, GLY154S, GLY155S, GLY20D, GLY55D, HIS101D, HIS133S, HIS87D, HIS88D, ILE131S, LEU153S, LEU84S, LEU8D, LEU94D, LEU99S, LYS125S, LYS132S, LYS18D, LYS19S, LYS215D, LYS22S, LYS336D, LYS33S, LYS34S, LYS50D, LYS61D, LYS92S, LYS95S, LYS96S, MET18S, MET305D, PHE15S, PHE21D, PHE31D, PHE90D, PRO243D, PRO26S, PRO27D, PRO98D, SER156S, SER23S, SER24S, SER94S, THR129S, THR25S, THR88S, THR91S, TRP340D, TYR240D, TYR337D, TYR53D, TYR85S, TYR89S, TYR91D, VAL100S, VAL20S, VAL29S, VAL30D, VAL36S, VAL54D, VAL57S, VAL96D
• E-F: ALA114F, ALA170F, ALA174F, ALA204E, ALA231E, ARG177F, ARG196E, ARG256E, ARG256F, ARG312F, ARG39E, ARG62E, ASN111F, ASN115F, ASN252E, ASN280F, ASP179F, ASP184E, ASP187E, CYS272F, GLN263F, GLN41E, GLU117F, GLU195E, GLU224F, GLU259F, GLU270E, GLU270F, GLU276F, GLU72F, GLY197E, GLY268E, GLY268F, GLY273F, GLY42E, GLY63E, HIS161F, HIS173F, HIS275F, HIS40E, HIS73E, HIS73F, ILE175F, ILE192E, ILE274F, ILE64E, ILE75F, LEU110F, LEU171F, LEU176F, LEU178F, LEU180F, LEU193E, LEU261F, LEU267E, LEU320F, LEU65E, LYS113F, LYS191E, LYS284F, LYS61E, MET190E, MET227E, MET227F, MET269E, MET269F, MET44E, PHE200E, PHE223F, PHE262F, PHE266E, PHE266F, PRO109F, PRO112F, PRO172F, PRO264E, PRO264F, SER199E, SER265E, SER265F, SER271F, SER60E, THR194E, THR201E, THR202E, THR203E, THR277F, THR77F, TYR169F, TYR188E, TYR198E, TYR69E, VAL43E, VAL76F
• E-G: ALA204E, ALA321G, ARG116G, ARG290G, ARG372G, ASP244E, ASP286G, ASP288G, ASP292G, CYS285G, CYS374G, GLN246E, GLN41E, GLN49E, GLU167G, GLU205E, GLU207E, GLU241E, GLY245E, GLY46E, GLY48E, HIS371G, ILE208E, ILE248E, ILE282G, ILE289G, LEU242E, LYS113G, LYS291G, LYS373G, LYS61E, MET283G, MET325G, MET44E, MET47E, PHE375G, PRO243E, PRO322G, SER199E, SER323G, SER60E, THR202E, THR324G, TYR166G, TYR169G, TYR294G, VAL287G, VAL370G, VAL43E, VAL45E
• E-P: ALA105P, ALA109P, ALA118P, ALA123P, ALA135E, ALA137P, ALA144E, ALA26E, ALA295E, ALA2P, ALA331E, ALA347E, ALA6P, ARG147E, ARG335E, ASN138P, ASN296E, ASN46P, ASP122P, ASP145P, ASP24E, ASP25E, ASP288E, ASP292E, ASP43P, CYS139P, CYS147P, CYS374E, CYS80P, GLN136P, GLN137E, GLN354E, GLU107E, GLU107P, GLU134P, GLU141P, GLU142P, GLU151P, GLU167E, GLU334E, GLY130P, GLY146E, GLY154P, GLY168E, GLY23E, GLY342E, GLY343E, GLY4P, ILE116P, ILE124P, ILE131P, ILE136E, ILE165E, ILE329E, ILE330E, ILE341E, ILE345E, ILE47P, LEU104E, LEU111P, LEU140E, LEU142E, LEU346E, LEU349E, LEU40P, LYS112P, LYS114P, LYS121P, LYS125P, LYS126P, LYS152P, LYS291E, LYS326E, LYS328E, LYS373E, LYS44P, LYS45P, MET115P, MET1P, MET355E, PHE103P, PHE352E, PHE375E, PRO106P, PRO332E, PRO333E, SER108P, SER113P, SER119P, SER120P, SER141E, SER145E, SER338E, SER344E, SER348E, SER350E, SER3P, THR148E, THR148P, THR149E, THR351E, TRP104P, TRP340E, TYR117P, TYR133E, TYR143E, TYR166E, TYR169E, TYR337E, TYR82P, VAL134E, VAL139E, VAL298E, VAL339E, VAL5P, VAL7P
• E-R: ALA157R, ALA19E, ALA26E, ALA29E, ALA35R, ALA87R, ALA97E, ARG210E, ARG21R, ARG28E, ARG32R, ARG95E, ASN16R, ASN92E, ASP17R, ASP211E, ASP24E, ASP25E, ASP2E, ASP3E, ASP51E, ASP56E, ASP86R, ASP98R, GLN49E, GLU100E, GLU151R, GLU214E, GLU241E, GLU57E, GLU90R, GLU93E, GLU93R, GLU97R, GLU99E, GLY130R, GLY154R, GLY155R, GLY20E, GLY55E, HIS101E, HIS133R, HIS87E, HIS88E, ILE131R, LEU153R, LEU84R, LEU8E, LEU94E, LEU99R, LYS125R, LYS132R, LYS18E, LYS19R, LYS215E, LYS22R, LYS336E, LYS33R, LYS34R, LYS50E, LYS61E, LYS92R, LYS95R, LYS96R, MET18R, MET305E, PHE15R, PHE21E, PHE31E, PHE90E, PRO243E, PRO26R, PRO27E, PRO98E, SER156R, SER23R, SER24R, SER94R, THR129R, THR25R, THR88R, THR91R, TRP340E, TYR240E, TYR337E, TYR53E, TYR85R, TYR89R, TYR91E, VAL100R, VAL20R, VAL29R, VAL30E, VAL36R, VAL54E, VAL57R, VAL96E
• F-G: ALA114G, ALA170G, ALA174G, ALA204F, ALA231F, ARG177G, ARG196F, ARG256F, ARG256G, ARG312G, ARG39F, ARG62F, ASN111G, ASN115G, ASN252F, ASN280G, ASP179G, ASP184F, ASP187F, CYS272G, GLN263G, GLN41F, GLU117G, GLU195F, GLU224G, GLU259G, GLU270F, GLU270G, GLU276G, GLU72G, GLY197F, GLY268F, GLY268G, GLY273G, GLY42F, GLY63F, HIS161G, HIS173G, HIS275G, HIS40F, HIS73F, HIS73G, ILE175G, ILE192F, ILE274G, ILE64F, ILE75G, LEU110G, LEU171G, LEU176G, LEU178G, LEU180G, LEU193F, LEU261G, LEU267F, LEU320G, LEU65F, LYS113G, LYS191F, LYS284G, LYS61F, MET190F, MET227F, MET227G, MET269F, MET269G, MET44F, PHE200F, PHE223G, PHE262G, PHE266F, PHE266G, PRO109G, PRO112G, PRO172G, PRO264F, PRO264G, SER199F, SER265F, SER265G, SER271G, SER60F, THR194F, THR201F, THR202F, THR203F, THR277G, THR77G, TYR169G, TYR188F, TYR198F, TYR69F, VAL43F, VAL76G
• F-H: ALA204F, ALA321H, ARG116H, ARG290H, ARG372H, ASP244F, ASP286H, ASP288H, ASP292H, CYS285H, CYS374H, GLN246F, GLN41F, GLN49F, GLU167H, GLU205F, GLU207F, GLU241F, GLY245F, GLY46F, GLY48F, HIS371H, ILE208F, ILE248F, ILE282H, ILE289H, LEU242F, LYS113H, LYS291H, LYS373H, LYS61F, MET283H, MET325H, MET44F, MET47F, PHE375H, PRO243F, PRO322H, SER199F, SER323H, SER60F, THR202F, THR324H, TYR166H, TYR169H, TYR294H, VAL287H, VAL370H, VAL43F, VAL45F
• F-S: ALA105S, ALA109S, ALA118S, ALA123S, ALA135F, ALA137S, ALA144F, ALA26F, ALA295F, ALA2S, ALA331F, ALA347F, ALA6S, ARG147F, ARG335F, ASN138S, ASN296F, ASN46S, ASP122S, ASP145S, ASP24F, ASP25F, ASP288F, ASP292F, ASP43S, CYS139S, CYS147S, CYS374F, CYS80S, GLN136S, GLN137F, GLN354F, GLU107F, GLU107S, GLU134S, GLU141S, GLU142S, GLU151S, GLU167F, GLU334F, GLY130S, GLY146F, GLY154S, GLY168F, GLY23F, GLY342F, GLY343F, GLY4S, ILE116S, ILE124S, ILE131S, ILE136F, ILE165F, ILE329F, ILE330F, ILE341F, ILE345F, ILE47S, LEU104F, LEU111S, LEU140F, LEU142F, LEU346F, LEU349F, LEU40S, LYS112S, LYS114S, LYS121S, LYS125S, LYS126S, LYS152S, LYS291F, LYS326F, LYS328F, LYS373F, LYS44S, LYS45S, MET115S, MET1S, MET355F, PHE103S, PHE352F, PHE375F, PRO106S, PRO332F, PRO333F, SER108S, SER113S, SER119S, SER120S, SER141F, SER145F, SER338F, SER344F, SER348F, SER350F, SER3S, THR148F, THR148S, THR149F, THR351F, TRP104S, TRP340F, TYR117S, TYR133F, TYR143F, TYR166F, TYR169F, TYR337F, TYR82S, VAL134F, VAL139F, VAL298F, VAL339F, VAL5S, VAL7S
• F-U: ALA157U, ALA19F, ALA26F, ALA29F, ALA35U, ALA87U, ALA97F, ARG210F, ARG21U, ARG28F, ARG32U, ARG95F, ASN16U, ASN92F, ASP17U, ASP211F, ASP24F, ASP25F, ASP2F, ASP3F, ASP51F, ASP56F, ASP86U, ASP98U, GLN49F, GLU100F, GLU151U, GLU214F, GLU241F, GLU57F, GLU90U, GLU93F, GLU93U, GLU97U, GLU99F, GLY130U, GLY154U, GLY155U, GLY20F, GLY55F, HIS101F, HIS133U, HIS87F, HIS88F, ILE131U, LEU153U, LEU84U, LEU8F, LEU94F, LEU99U, LYS125U, LYS132U, LYS18F, LYS19U, LYS215F, LYS22U, LYS336F, LYS33U, LYS34U, LYS50F, LYS61F, LYS92U, LYS95U, LYS96U, MET18U, MET305F, PHE15U, PHE21F, PHE31F, PHE90F, PRO243F, PRO26U, PRO27F, PRO98F, SER156U, SER23U, SER24U, SER94U, THR129U, THR25U, THR88U, THR91U, TRP340F, TYR240F, TYR337F, TYR53F, TYR85U, TYR89U, TYR91F, VAL100U, VAL20U, VAL29U, VAL30F, VAL36U, VAL54F, VAL57U, VAL96F
• G-H: ALA114H, ALA170H, ALA174H, ALA204G, ALA231G, ARG177H, ARG196G, ARG256G, ARG256H, ARG312H, ARG39G, ARG62G, ASN111H, ASN115H, ASN252G, ASN280H, ASP179H, ASP184G, ASP187G, CYS272H, GLN263H, GLN41G, GLU117H, GLU195G, GLU224H, GLU259H, GLU270G, GLU270H, GLU276H, GLU72H, GLY197G, GLY268G, GLY268H, GLY273H, GLY42G, GLY63G, HIS161H, HIS173H, HIS275H, HIS40G, HIS73G, HIS73H, ILE175H, ILE192G, ILE274H, ILE64G, ILE75H, LEU110H, LEU171H, LEU176H, LEU178H, LEU180H, LEU193G, LEU261H, LEU267G, LEU320H, LEU65G, LYS113H, LYS191G, LYS284H, LYS61G, MET190G, MET227G, MET227H, MET269G, MET269H, MET44G, PHE200G, PHE223H, PHE262H, PHE266G, PHE266H, PRO109H, PRO112H, PRO172H, PRO264G, PRO264H, SER199G, SER265G, SER265H, SER271H, SER60G, THR194G, THR201G, THR202G, THR203G, THR277H, THR77H, TYR169H, TYR188G, TYR198G, TYR69G, VAL43G, VAL76H
• G-I: ALA204G, ALA321I, ARG116I, ARG290I, ARG372I, ASP244G, ASP286I, ASP288I, ASP292I, CYS285I, CYS374I, GLN246G, GLN41G, GLN49G, GLU167I, GLU205G, GLU207G, GLU241G, GLY245G, GLY46G, GLY48G, HIS371I, ILE208G, ILE248G, ILE282I, ILE289I, LEU242G, LYS113I, LYS291I, LYS373I, LYS61G, MET283I, MET325I, MET44G, MET47G, PHE375I, PRO243G, PRO322I, SER199G, SER323I, SER60G, THR202G, THR324I, TYR166I, TYR169I, TYR294I, VAL287I, VAL370I, VAL43G, VAL45G
• G-R: ALA105R, ALA109R, ALA118R, ALA123R, ALA135G, ALA137R, ALA144G, ALA26G, ALA295G, ALA2R, ALA331G, ALA347G, ALA6R, ARG147G, ARG335G, ASN138R, ASN296G, ASN46R, ASP122R, ASP145R, ASP24G, ASP25G, ASP288G, ASP292G, ASP43R, CYS139R, CYS147R, CYS374G, CYS80R, GLN136R, GLN137G, GLN354G, GLU107G, GLU107R, GLU134R, GLU141R, GLU142R, GLU151R, GLU167G, GLU334G, GLY130R, GLY146G, GLY154R, GLY168G, GLY23G, GLY342G, GLY343G, GLY4R, ILE116R, ILE124R, ILE131R, ILE136G, ILE165G, ILE329G, ILE330G, ILE341G, ILE345G, ILE47R, LEU104G, LEU111R, LEU140G, LEU142G, LEU346G, LEU349G, LEU40R, LYS112R, LYS114R, LYS121R, LYS125R, LYS126R, LYS152R, LYS291G, LYS326G, LYS328G, LYS373G, LYS44R, LYS45R, MET115R, MET1R, MET355G, PHE103R, PHE352G, PHE375G, PRO106R, PRO332G, PRO333G, SER108R, SER113R, SER119R, SER120R, SER141G, SER145G, SER338G, SER344G, SER348G, SER350G, SER3R, THR148G, THR148R, THR149G, THR351G, TRP104R, TRP340G, TYR117R, TYR133G, TYR143G, TYR166G, TYR169G, TYR337G, TYR82R, VAL134G, VAL139G, VAL298G, VAL339G, VAL5R, VAL7R
• G-T: ALA157T, ALA19G, ALA26G, ALA29G, ALA35T, ALA87T, ALA97G, ARG210G, ARG21T, ARG28G, ARG32T, ARG95G, ASN16T, ASN92G, ASP17T, ASP211G, ASP24G, ASP25G, ASP2G, ASP3G, ASP51G, ASP56G, ASP86T, ASP98T, GLN49G, GLU100G, GLU151T, GLU214G, GLU241G, GLU57G, GLU90T, GLU93G, GLU93T, GLU97T, GLU99G, GLY130T, GLY154T, GLY155T, GLY20G, GLY55G, HIS101G, HIS133T, HIS87G, HIS88G, ILE131T, LEU153T, LEU84T, LEU8G, LEU94G, LEU99T, LYS125T, LYS132T, LYS18G, LYS19T, LYS215G, LYS22T, LYS336G, LYS33T, LYS34T, LYS50G, LYS61G, LYS92T, LYS95T, LYS96T, MET18T, MET305G, PHE15T, PHE21G, PHE31G, PHE90G, PRO243G, PRO26T, PRO27G, PRO98G, SER156T, SER23T, SER24T, SER94T, THR129T, THR25T, THR88T, THR91T, TRP340G, TYR240G, TYR337G, TYR53G, TYR85T, TYR89T, TYR91G, VAL100T, VAL20T, VAL29T, VAL30G, VAL36T, VAL54G, VAL57T, VAL96G
• H-I: ALA114I, ALA170I, ALA174I, ALA204H, ALA231H, ARG177I, ARG196H, ARG256H, ARG256I, ARG312I, ARG39H, ARG62H, ASN111I, ASN115I, ASN252H, ASN280I, ASP179I, ASP184H, ASP187H, CYS272I, GLN263I, GLN41H, GLU117I, GLU195H, GLU224I, GLU259I, GLU270H, GLU270I, GLU276I, GLU72I, GLY197H, GLY268H, GLY268I, GLY273I, GLY42H, GLY63H, HIS161I, HIS173I, HIS275I, HIS40H, HIS73H, HIS73I, ILE175I, ILE192H, ILE274I, ILE64H, ILE75I, LEU110I, LEU171I, LEU176I, LEU178I, LEU180I, LEU193H, LEU261I, LEU267H, LEU320I, LEU65H, LYS113I, LYS191H, LYS284I, LYS61H, MET190H, MET227H, MET227I, MET269H, MET269I, MET44H, PHE200H, PHE223I, PHE262I, PHE266H, PHE266I, PRO109I, PRO112I, PRO172I, PRO264H, PRO264I, SER199H, SER265H, SER265I, SER271I, SER60H, THR194H, THR201H, THR202H, THR203H, THR277I, THR77I, TYR169I, TYR188H, TYR198H, TYR69H, VAL43H, VAL76I
• H-J: ALA204H, ALA321J, ARG116J, ARG290J, ARG372J, ASP244H, ASP286J, ASP288J, ASP292J, CYS285J, CYS374J, GLN246H, GLN41H, GLN49H, GLU167J, GLU205H, GLU207H, GLU241H, GLY245H, GLY46H, GLY48H, HIS371J, ILE208H, ILE248H, ILE282J, ILE289J, LEU242H, LYS113J, LYS291J, LYS373J, LYS61H, MET283J, MET325J, MET44H, MET47H, PHE375J, PRO243H, PRO322J, SER199H, SER323J, SER60H, THR202H, THR324J, TYR166J, TYR169J, TYR294J, VAL287J, VAL370J, VAL43H, VAL45H
• H-U: ALA105U, ALA109U, ALA118U, ALA123U, ALA135H, ALA137U, ALA144H, ALA26H, ALA295H, ALA2U, ALA331H, ALA347H, ALA6U, ARG147H, ARG335H, ASN138U, ASN296H, ASN46U, ASP122U, ASP145U, ASP24H, ASP25H, ASP288H, ASP292H, ASP43U, CYS139U, CYS147U, CYS374H, CYS80U, GLN136U, GLN137H, GLN354H, GLU107H, GLU107U, GLU134U, GLU141U, GLU142U, GLU151U, GLU167H, GLU334H, GLY130U, GLY146H, GLY154U, GLY168H, GLY23H, GLY342H, GLY343H, GLY4U, ILE116U, ILE124U, ILE131U, ILE136H, ILE165H, ILE329H, ILE330H, ILE341H, ILE345H, ILE47U, LEU104H, LEU111U, LEU140H, LEU142H, LEU346H, LEU349H, LEU40U, LYS112U, LYS114U, LYS121U, LYS125U, LYS126U, LYS152U, LYS291H, LYS326H, LYS328H, LYS373H, LYS44U, LYS45U, MET115U, MET1U, MET355H, PHE103U, PHE352H, PHE375H, PRO106U, PRO332H, PRO333H, SER108U, SER113U, SER119U, SER120U, SER141H, SER145H, SER338H, SER344H, SER348H, SER350H, SER3U, THR148H, THR148U, THR149H, THR351H, TRP104U, TRP340H, TYR117U, TYR133H, TYR143H, TYR166H, TYR169H, TYR337H, TYR82U, VAL134H, VAL139H, VAL298H, VAL339H, VAL5U, VAL7U
• H-W: ALA157W, ALA19H, ALA26H, ALA29H, ALA35W, ALA87W, ALA97H, ARG210H, ARG21W, ARG28H, ARG32W, ARG95H, ASN16W, ASN92H, ASP17W, ASP211H, ASP24H, ASP25H, ASP2H, ASP3H, ASP51H, ASP56H, ASP86W, ASP98W, GLN49H, GLU100H, GLU151W, GLU214H, GLU241H, GLU57H, GLU90W, GLU93H, GLU93W, GLU97W, GLU99H, GLY130W, GLY154W, GLY155W, GLY20H, GLY55H, HIS101H, HIS133W, HIS87H, HIS88H, ILE131W, LEU153W, LEU84W, LEU8H, LEU94H, LEU99W, LYS125W, LYS132W, LYS18H, LYS19W, LYS215H, LYS22W, LYS336H, LYS33W, LYS34W, LYS50H, LYS61H, LYS92W, LYS95W, LYS96W, MET18W, MET305H, PHE15W, PHE21H, PHE31H, PHE90H, PRO243H, PRO26W, PRO27H, PRO98H, SER156W, SER23W, SER24W, SER94W, THR129W, THR25W, THR88W, THR91W, TRP340H, TYR240H, TYR337H, TYR53H, TYR85W, TYR89W, TYR91H, VAL100W, VAL20W, VAL29W, VAL30H, VAL36W, VAL54H, VAL57W, VAL96H
• I-J: ALA114J, ALA170J, ALA174J, ALA204I, ALA231I, ARG177J, ARG196I, ARG256I, ARG256J, ARG312J, ARG39I, ARG62I, ASN111J, ASN115J, ASN252I, ASN280J, ASP179J, ASP184I, ASP187I, CYS272J, GLN263J, GLN41I, GLU117J, GLU195I, GLU224J, GLU259J, GLU270I, GLU270J, GLU276J, GLU72J, GLY197I, GLY268I, GLY268J, GLY273J, GLY42I, GLY63I, HIS161J, HIS173J, HIS275J, HIS40I, HIS73I, HIS73J, ILE175J, ILE192I, ILE274J, ILE64I, ILE75J, LEU110J, LEU171J, LEU176J, LEU178J, LEU180J, LEU193I, LEU261J, LEU267I, LEU320J, LEU65I, LYS113J, LYS191I, LYS284J, LYS61I, MET190I, MET227I, MET227J, MET269I, MET269J, MET44I, PHE200I, PHE223J, PHE262J, PHE266I, PHE266J, PRO109J, PRO112J, PRO172J, PRO264I, PRO264J, SER199I, SER265I, SER265J, SER271J, SER60I, THR194I, THR201I, THR202I, THR203I, THR277J, THR77J, TYR169J, TYR188I, TYR198I, TYR69I, VAL43I, VAL76J
• I-K: ALA204I, ALA321K, ARG116K, ARG290K, ARG372K, ASP244I, ASP286K, ASP288K, ASP292K, CYS285K, CYS374K, GLN246I, GLN41I, GLN49I, GLU167K, GLU205I, GLU207I, GLU241I, GLY245I, GLY46I, GLY48I, HIS371K, ILE208I, ILE248I, ILE282K, ILE289K, LEU242I, LYS113K, LYS291K, LYS373K, LYS61I, MET283K, MET325K, MET44I, MET47I, PHE375K, PRO243I, PRO322K, SER199I, SER323K, SER60I, THR202I, THR324K, TYR166K, TYR169K, TYR294K, VAL287K, VAL370K, VAL43I, VAL45I
• I-T: ALA105T, ALA109T, ALA118T, ALA123T, ALA135I, ALA137T, ALA144I, ALA26I, ALA295I, ALA2T, ALA331I, ALA347I, ALA6T, ARG147I, ARG335I, ASN138T, ASN296I, ASN46T, ASP122T, ASP145T, ASP24I, ASP25I, ASP288I, ASP292I, ASP43T, CYS139T, CYS147T, CYS374I, CYS80T, GLN136T, GLN137I, GLN354I, GLU107I, GLU107T, GLU134T, GLU141T, GLU142T, GLU151T, GLU167I, GLU334I, GLY130T, GLY146I, GLY154T, GLY168I, GLY23I, GLY342I, GLY343I, GLY4T, ILE116T, ILE124T, ILE131T, ILE136I, ILE165I, ILE329I, ILE330I, ILE341I, ILE345I, ILE47T, LEU104I, LEU111T, LEU140I, LEU142I, LEU346I, LEU349I, LEU40T, LYS112T, LYS114T, LYS121T, LYS125T, LYS126T, LYS152T, LYS291I, LYS326I, LYS328I, LYS373I, LYS44T, LYS45T, MET115T, MET1T, MET355I, PHE103T, PHE352I, PHE375I, PRO106T, PRO332I, PRO333I, SER108T, SER113T, SER119T, SER120T, SER141I, SER145I, SER338I, SER344I, SER348I, SER350I, SER3T, THR148I, THR148T, THR149I, THR351I, TRP104T, TRP340I, TYR117T, TYR133I, TYR143I, TYR166I, TYR169I, TYR337I, TYR82T, VAL134I, VAL139I, VAL298I, VAL339I, VAL5T, VAL7T
• I-V: ALA157V, ALA19I, ALA26I, ALA29I, ALA35V, ALA87V, ALA97I, ARG210I, ARG21V, ARG28I, ARG32V, ARG95I, ASN16V, ASN92I, ASP17V, ASP211I, ASP24I, ASP25I, ASP2I, ASP3I, ASP51I, ASP56I, ASP86V, ASP98V, GLN49I, GLU100I, GLU151V, GLU214I, GLU241I, GLU57I, GLU90V, GLU93I, GLU93V, GLU97V, GLU99I, GLY130V, GLY154V, GLY155V, GLY20I, GLY55I, HIS101I, HIS133V, HIS87I, HIS88I, ILE131V, LEU153V, LEU84V, LEU8I, LEU94I, LEU99V, LYS125V, LYS132V, LYS18I, LYS19V, LYS215I, LYS22V, LYS336I, LYS33V, LYS34V, LYS50I, LYS61I, LYS92V, LYS95V, LYS96V, MET18V, MET305I, PHE15V, PHE21I, PHE31I, PHE90I, PRO243I, PRO26V, PRO27I, PRO98I, SER156V, SER23V, SER24V, SER94V, THR129V, THR25V, THR88V, THR91V, TRP340I, TYR240I, TYR337I, TYR53I, TYR85V, TYR89V, TYR91I, VAL100V, VAL20V, VAL29V, VAL30I, VAL36V, VAL54I, VAL57V, VAL96I
• J-K: ALA114K, ALA170K, ALA174K, ALA204J, ALA231J, ARG177K, ARG196J, ARG256J, ARG256K, ARG312K, ARG39J, ARG62J, ASN111K, ASN115K, ASN252J, ASN280K, ASP179K, ASP184J, ASP187J, CYS272K, GLN263K, GLN41J, GLU117K, GLU195J, GLU224K, GLU259K, GLU270J, GLU270K, GLU276K, GLU72K, GLY197J, GLY268J, GLY268K, GLY273K, GLY42J, GLY63J, HIS161K, HIS173K, HIS275K, HIS40J, HIS73J, HIS73K, ILE175K, ILE192J, ILE274K, ILE64J, ILE75K, LEU110K, LEU171K, LEU176K, LEU178K, LEU180K, LEU193J, LEU261K, LEU267J, LEU320K, LEU65J, LYS113K, LYS191J, LYS284K, LYS61J, MET190J, MET227J, MET227K, MET269J, MET269K, MET44J, PHE200J, PHE223K, PHE262K, PHE266J, PHE266K, PRO109K, PRO112K, PRO172K, PRO264J, PRO264K, SER199J, SER265J, SER265K, SER271K, SER60J, THR194J, THR201J, THR202J, THR203J, THR277K, THR77K, TYR169K, TYR188J, TYR198J, TYR69J, VAL43J, VAL76K
• J-L: ALA204J, ALA321L, ARG116L, ARG290L, ARG372L, ASP244J, ASP286L, ASP288L, ASP292L, CYS285L, CYS374L, GLN246J, GLN41J, GLN49J, GLU167L, GLU205J, GLU207J, GLU241J, GLY245J, GLY46J, GLY48J, HIS371L, ILE208J, ILE248J, ILE282L, ILE289L, LEU242J, LYS113L, LYS291L, LYS373L, LYS61J, MET283L, MET325L, MET44J, MET47J, PHE375L, PRO243J, PRO322L, SER199J, SER323L, SER60J, THR202J, THR324L, TYR166L, TYR169L, TYR294L, VAL287L, VAL370L, VAL43J, VAL45J
• J-W: ALA105W, ALA109W, ALA118W, ALA123W, ALA135J, ALA137W, ALA144J, ALA26J, ALA295J, ALA2W, ALA331J, ALA347J, ALA6W, ARG147J, ARG335J, ASN138W, ASN296J, ASN46W, ASP122W, ASP145W, ASP24J, ASP25J, ASP288J, ASP292J, ASP43W, CYS139W, CYS147W, CYS374J, CYS80W, GLN136W, GLN137J, GLN354J, GLU107J, GLU107W, GLU134W, GLU141W, GLU142W, GLU151W, GLU167J, GLU334J, GLY130W, GLY146J, GLY154W, GLY168J, GLY23J, GLY342J, GLY343J, GLY4W, ILE116W, ILE124W, ILE131W, ILE136J, ILE165J, ILE329J, ILE330J, ILE341J, ILE345J, ILE47W, LEU104J, LEU111W, LEU140J, LEU142J, LEU346J, LEU349J, LEU40W, LYS112W, LYS114W, LYS121W, LYS125W, LYS126W, LYS152W, LYS291J, LYS326J, LYS328J, LYS373J, LYS44W, LYS45W, MET115W, MET1W, MET355J, PHE103W, PHE352J, PHE375J, PRO106W, PRO332J, PRO333J, SER108W, SER113W, SER119W, SER120W, SER141J, SER145J, SER338J, SER344J, SER348J, SER350J, SER3W, THR148J, THR148W, THR149J, THR351J, TRP104W, TRP340J, TYR117W, TYR133J, TYR143J, TYR166J, TYR169J, TYR337J, TYR82W, VAL134J, VAL139J, VAL298J, VAL339J, VAL5W, VAL7W
• J-X: ALA35X, ALA97J, ARG21X, ARG28J, ARG32X, ARG95J, ASN16X, ASN92J, ASP17X, ASP24J, ASP2J, ASP3J, ASP56J, ASP86X, ASP98X, GLU100J, GLU57J, GLU93J, GLU93X, GLU97X, GLU99J, HIS101J, HIS133X, HIS87J, HIS88J, LEU84X, LEU8J, LEU94J, LYS132X, LYS18J, LYS19X, LYS22X, LYS33X, LYS34X, LYS95X, LYS96X, MET18X, PHE15X, PHE21J, PHE90J, PRO26X, PRO98J, SER23X, SER24X, THR25X, TYR85X, TYR91J, VAL20X, VAL29X, VAL36X, VAL57X, VAL96J
• K-L: ALA114L, ALA170L, ALA174L, ALA204K, ALA231K, ARG177L, ARG196K, ARG256K, ARG256L, ARG312L, ARG39K, ARG62K, ASN111L, ASN115L, ASN252K, ASN280L, ASP179L, ASP184K, ASP187K, CYS272L, GLN263L, GLN41K, GLU117L, GLU195K, GLU224L, GLU259L, GLU270K, GLU270L, GLU276L, GLU72L, GLY197K, GLY268K, GLY268L, GLY273L, GLY42K, GLY63K, HIS161L, HIS173L, HIS275L, HIS40K, HIS73K, HIS73L, ILE175L, ILE192K, ILE274L, ILE64K, ILE75L, LEU110L, LEU171L, LEU176L, LEU178L, LEU180L, LEU193K, LEU261L, LEU267K, LEU320L, LEU65K, LYS113L, LYS191K, LYS284L, LYS61K, MET190K, MET227K, MET227L, MET269K, MET269L, MET44K, PHE200K, PHE223L, PHE262L, PHE266K, PHE266L, PRO109L, PRO112L, PRO172L, PRO264K, PRO264L, SER199K, SER265K, SER265L, SER271L, SER60K, THR194K, THR201K, THR202K, THR203K, THR277L, THR77L, TYR169L, TYR188K, TYR198K, TYR69K, VAL43K, VAL76L
• K-V: ALA105V, ALA109V, ALA118V, ALA123V, ALA135K, ALA137V, ALA144K, ALA26K, ALA295K, ALA2V, ALA331K, ALA347K, ALA6V, ARG147K, ARG335K, ASN138V, ASN296K, ASN46V, ASP122V, ASP145V, ASP24K, ASP25K, ASP288K, ASP292K, ASP43V, CYS139V, CYS147V, CYS374K, CYS80V, GLN136V, GLN137K, GLN354K, GLU107K, GLU107V, GLU134V, GLU141V, GLU142V, GLU151V, GLU167K, GLU334K, GLY130V, GLY146K, GLY154V, GLY168K, GLY23K, GLY342K, GLY343K, GLY4V, ILE116V, ILE124V, ILE131V, ILE136K, ILE165K, ILE329K, ILE330K, ILE341K, ILE345K, ILE47V, LEU104K, LEU111V, LEU140K, LEU142K, LEU346K, LEU349K, LEU40V, LYS112V, LYS114V, LYS121V, LYS125V, LYS126V, LYS152V, LYS291K, LYS326K, LYS328K, LYS373K, LYS44V, LYS45V, MET115V, MET1V, MET355K, PHE103V, PHE352K, PHE375K, PRO106V, PRO332K, PRO333K, SER108V, SER113V, SER119V, SER120V, SER141K, SER145K, SER338K, SER344K, SER348K, SER350K, SER3V, THR148K, THR148V, THR149K, THR351K, TRP104V, TRP340K, TYR117V, TYR133K, TYR143K, TYR166K, TYR169K, TYR337K, TYR82V, VAL134K, VAL139K, VAL298K, VAL339K, VAL5V, VAL7V
• L-X: ALA135L, ALA144L, ALA2X, ALA347L, ALA6X, ARG147L, ASN138X, ASN46X, ASP122X, ASP25L, ASP292L, ASP43X, CYS374L, CYS80X, GLN136X, GLN137L, GLN354L, GLU107L, GLU107X, GLU142X, GLU151X, GLU167L, GLU334L, GLY146L, GLY168L, GLY342L, GLY343L, GLY4X, ILE136L, ILE341L, ILE345L, ILE47X, LEU104L, LEU140L, LEU142L, LEU346L, LEU349L, LEU40X, LYS112X, LYS114X, LYS121X, LYS125X, LYS291L, LYS328L, LYS373L, LYS44X, LYS45X, MET1X, MET355L, PHE352L, PHE375L, SER119X, SER141L, SER145L, SER338L, SER344L, SER350L, SER3X, THR351L, TYR133L, TYR143L, TYR82X, VAL134L, VAL139L, VAL339L, VAL5X, VAL7X