3J0C

models of e1, e2 and cp of venezuelan equine encephalitis virus tc-83 strain restrained by a near atomic resolution cryo-em map

• Total interactions analyzed: 66
• Total true interactions: 26
• Strongest Interaction:
  • Chains: K-L
  • Int. Res.: 67
  • Norm. En. per Res.: -2.9189
• Hub Node: A(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-137.044	16.6452	-692.194	-812.5929	338	24	21	29163	3	66	75
A-C	0.0	4.3896	-51.278	-46.8884	30	3	0	2354	0	1	7
A-D	-10.2638	-4.0347	-76.9474	-91.246	66	3	0	3451	5	10	12
A-G	-13.6108	-5.3336	-61.7473	-80.6918	42	1	1	2990	2	13	10
A-H	0.0	0.0	-2.0776	-2.0776	16	0	0	351	0	1	5
B-C	-16.1312	4.2934	-156.72	-168.5578	69	7	2	7388	0	7	21
C-H	0.0	-15.4048	-7.9566	-23.3614	12	0	0	433	0	3	1
C-I	-9.3612	-22.4031	-38.336	-70.1003	32	3	0	1649	2	10	8
D-E	-134.7839	-2.6274	-725.143	-862.5543	334	28	24	29487	5	68	78
D-F	-3.2866	-6.4014	-56.6008	-66.2888	31	5	0	2782	0	2	7
D-H	-17.6558	-11.2096	-77.964	-106.8293	56	3	0	4102	0	16	9
E-F	-10.635	1.0439	-137.969	-147.5601	67	2	2	6844	0	7	22
E-H	-13.6131	-11.9466	-124.352	-149.9117	76	11	1	5499	0	21	31
E-J	-20.0691	4.3332	-84.2714	-100.0073	54	2	0	4049	1	15	9
E-K	-14.1256	-9.1628	-88.5389	-111.8273	67	4	1	4421	0	21	26
F-I	0.0	0.0	-0.6495	-0.6495	10	0	0	84	0	6	5
F-L	0.0	-6.5302	-5.216	-11.7462	16	0	0	704	0	8	9
G-H	-125.1639	-2.9873	-672.934	-801.0852	318	25	17	27559	3	66	75
G-I	-6.8271	2.4704	-59.706	-64.0627	30	8	0	2641	0	1	7
G-K	-9.5224	-4.4307	-70.0748	-84.0279	56	3	0	3658	0	14	10
H-I	-17.9691	-26.1581	-149.567	-193.6942	68	4	2	7223	1	7	23
H-K	-25.93	-25.9876	-113.595	-165.5126	78	10	1	5153	1	22	30
I-L	-7.4646	-14.7549	-8.2191	-30.4386	19	1	0	614	1	8	7
J-K	-143.5143	-34.2232	-708.432	-886.1695	326	25	19	28879	6	66	81
J-L	-13.7309	-6.5717	-66.3271	-86.6297	30	5	0	2797	1	2	7
K-L	-17.0772	-29.1472	-149.339	-195.5634	67	2	2	7369	2	7	22

Interface residues

• A-B: ALA106A, ALA116A, ALA150B, ALA163B, ALA17B, ALA181A, ALA226A, ALA228A, ALA228B, ALA246B, ALA247B, ALA248A, ALA255A, ALA262B, ALA272A, ALA301B, ALA340B, ALA344B, ALA359A, ALA35B, ALA375B, ALA376B, ALA378B, ALA383B, ALA384B, ALA395A, ALA395B, ALA400A, ALA401A, ALA406A, ALA418A, ALA428A, ALA432A, ALA59A, ALA92A, ARG136B, ARG161B, ARG18B, ARG21B, ARG227B, ARG230B, ARG281B, ARG298B, ARG337B, ARG362B, ARG391B, ARG393B, ARG46B, ARG73A, ASN100A, ASN132B, ASN239B, ASN270A, ASN347B, ASN360A, ASN438A, ASP112A, ASP113A, ASP117A, ASP175B, ASP241B, ASP263B, ASP302B, ASP311A, ASP379A, ASP385A, ASP39B, ASP56A, ASP69B, CYS114A, CYS151B, CYS200B, CYS202B, CYS226B, CYS259A, CYS271A, CYS27B, CYS374B, CYS380A, CYS396B, CYS417B, CYS62A, CYS63A, CYS68A, CYS94A, CYS96A, GLN102A, GLN10A, GLN152B, GLN225B, GLN299B, GLN341B, GLN392A, GLN396A, GLN439A, GLN48B, GLN66A, GLU128B, GLU166B, GLU173B, GLU183A, GLU199B, GLU201B, GLU224B, GLU241A, GLU260A, GLU269A, GLU303B, GLU309B, GLU323B, GLU327B, GLU342B, GLU34B, GLU354B, GLU67A, GLU99A, GLY135B, GLY162B, GLY171B, GLY182A, GLY227A, GLY258A, GLY279B, GLY325B, GLY331B, GLY346B, GLY350B, GLY370B, GLY40B, GLY415A, GLY416A, GLY424A, GLY54A, GLY64A, GLY72B, GLY90A, GLY91A, HIS118A, HIS121B, HIS168B, HIS230A, HIS256B, HIS28B, HIS305B, HIS308B, HIS349B, HIS353B, HIS362A, HIS381A, HIS386A, HIS390A, HIS394A, HIS41B, HIS50A, HIS71B, ILE13A, ILE20B, ILE229A, ILE261A, ILE276B, ILE296B, ILE31B, ILE356B, ILE361A, ILE373B, ILE377B, ILE387A, ILE420A, ILE421A, ILE422A, ILE423A, ILE60A, LEU115A, LEU169B, LEU178B, LEU197B, LEU243B, LEU251A, LEU255B, LEU260B, LEU261B, LEU295B, LEU300B, LEU351B, LEU371B, LEU388B, LEU410A, LEU413A, LEU414A, LEU415B, LEU425A, LEU427A, LYS105A, LYS110A, LYS116B, LYS130B, LYS222B, LYS223B, LYS225A, LYS242B, LYS244A, LYS245A, LYS245B, LYS247A, LYS252A, LYS252B, LYS254B, LYS324B, LYS336B, LYS37B, LYS384A, LYS404A, LYS52A, LYS61A, MET109A, MET16B, MET55A, MET70B, MET88A, PHE131B, PHE240A, PHE253A, PHE257A, PHE259B, PHE278B, PHE280B, PHE338B, PHE389B, PHE87A, PHE95A, PHE99B, PRO133B, PRO170B, PRO232A, PRO237A, PRO244B, PRO249A, PRO256A, PRO304B, PRO30B, PRO335B, PRO348B, PRO352B, PRO382A, PRO383A, PRO391A, PRO399B, PRO58A, PRO86A, SER104A, SER111A, SER172B, SER176B, SER177B, SER240B, SER250A, SER26B, SER282B, SER29B, SER309A, SER310A, SER381B, SER385B, SER38B, SER392B, SER403A, SER417A, SER57A, THR250B, THR254A, THR277B, THR297B, THR307B, THR343B, THR357B, THR367B, THR379B, THR386B, THR389A, THR397A, THR398B, THR405A, THR411A, THR429A, THR53A, THR73B, TRP170A, TRP326B, TRP339B, TRP387B, TRP407A, TRP409A, TRP89A, TYR107A, TYR127B, TYR154B, TYR164B, TYR180A, TYR229B, TYR233A, TYR238B, TYR262A, TYR294B, TYR306B, TYR308A, TYR359B, TYR360B, TYR363B, TYR393A, TYR400B, TYR434A, TYR51A, TYR68B, TYR85A, TYR93A, VAL103A, VAL134B, VAL153B, VAL165B, VAL174B, VAL231A, VAL237B, VAL257B, VAL273A, VAL283B, VAL307A, VAL321B, VAL329B, VAL355B, VAL380B, VAL382B, VAL388A, VAL394B, VAL402A, VAL419A, VAL426A, VAL431A, VAL435A
• A-C: ALA432A, ASN211C, ASN259C, ASN438A, ASN442A, GLN439A, GLU260C, GLY212C, HIS193C, HIS441A, LEU436A, LYS172C, LYS195C, LYS261C, LYS266C, LYS440A, MET257C, THR264C, THR437A, TRP258C, TYR173C, TYR191C, TYR209C, TYR267C, TYR434A, VAL238C, VAL256C, VAL263C, VAL265C, VAL435A
• A-D: ALA127A, ALA127D, ALA194A, ALA194D, ARG175A, ARG175D, ARG206A, ARG206D, ASN149A, ASN149D, ASN155A, ASN155D, ASN216A, ASN216D, ASN43A, ASN43D, GLN130A, GLN130D, GLN196A, GLN196D, GLN204D, GLU151A, GLU151D, GLU191A, GLU191D, GLU45A, GLU45D, GLY150A, GLY150D, GLY193A, GLY193D, GLY195D, HIS125A, HIS125D, LYS123A, LYS123D, LYS160A, LYS160D, LYS176A, LYS176D, PHE189D, PRO153A, PRO153D, PRO165A, PRO190D, PRO40D, SER128A, SER128D, THR126A, THR126D, THR152A, THR152D, THR41A, THR41D, TYR147A, TYR147D, TYR192A, TYR192D, TYR214A, TYR214D, TYR46D, VAL146A, VAL154A, VAL154D, VAL42A, VAL42D
• A-G: ALA22A, ARG21A, ARG289A, ASN20A, ASN304G, ASP284A, ASP311G, ASP385G, CYS306G, CYS380G, GLU292A, GLU2A, GLU305G, GLY23A, GLY313G, HIS355G, HIS381G, HIS386G, ILE282A, ILE315G, LEU303G, LYS319G, LYS384G, PHE287A, PHE312G, PRO283A, PRO382G, PRO383G, SER291A, SER297A, SER309G, SER310G, SER323A, THR293A, THR295A, THR371A, TYR1A, TYR24A, TYR308G, VAL19A, VAL290A, VAL307G
• A-H: ALA413H, ALA421H, ALA423H, ARG21A, ARG422H, ASN442A, HIS441A, ILE408H, LEU412H, LEU436A, LYS440A, PHE410H, PRO348H, PRO409H, THR420H, THR437A
• B-C: ALA170C, ALA178C, ALA239C, ALA395B, ALA406B, ALA421B, ARG149C, ARG185C, ARG391B, ARG401B, ARG407B, ARG419B, ARG422B, ASN259C, ASN405B, ASP174C, ASP179C, CYS141C, CYS411B, GLN182C, GLU176C, GLU260C, GLY144C, GLY145C, GLY227C, GLY262C, HIS193C, ILE240C, ILE408B, LEU147C, LEU175C, LEU242C, LEU397B, LEU402B, LEU415B, LYS146C, LYS168C, LYS169C, LYS172C, LYS190C, LYS261C, LYS266C, MET257C, PHE148C, PHE189C, PHE410B, PRO150C, PRO181C, PRO399B, PRO404B, SER171C, THR188C, THR192C, THR264C, THR398B, THR403B, TRP258C, TYR173C, TYR177C, TYR191C, TYR400B, VAL142C, VAL143C, VAL180C, VAL237C, VAL256C, VAL263C, VAL265C, VAL394B
• C-H: ALA406H, ALA423H, ARG213C, ARG407H, ARG422H, ASN211C, ASN271C, ASN405H, GLU270C, PRO269C, THR268C, TYR267C
• C-I: ALA186I, ALA252C, ARG185I, ARG213C, ARG236I, ARG250C, ASN183I, ASN211C, ASN246C, ASN271C, ASP187I, CYS272C, GLN182I, GLN197C, GLN208C, GLU210C, GLU247C, GLU270C, GLY144I, GLY248C, LYS126I, LYS190I, LYS218C, MET184I, PRO181I, PRO269C, SER249C, THR188I, THR215C, THR251C, TYR191I, VAL245C
• D-E: ALA106D, ALA116D, ALA150E, ALA163E, ALA17E, ALA181D, ALA228D, ALA228E, ALA246E, ALA247E, ALA248D, ALA255D, ALA262E, ALA272D, ALA301E, ALA340E, ALA344E, ALA359D, ALA35E, ALA375E, ALA376E, ALA378E, ALA383E, ALA384E, ALA395E, ALA400D, ALA401D, ALA406D, ALA418D, ALA428D, ALA432D, ALA59D, ALA92D, ARG136E, ARG161E, ARG18E, ARG21E, ARG227E, ARG230E, ARG281E, ARG298E, ARG337E, ARG362E, ARG391E, ARG393E, ARG46E, ARG73D, ASN100D, ASN132E, ASN239E, ASN270D, ASN332E, ASN347E, ASN438D, ASP112D, ASP113D, ASP117D, ASP175E, ASP241E, ASP263E, ASP302E, ASP311D, ASP379D, ASP385D, ASP39E, ASP56D, ASP69E, CYS114D, CYS151E, CYS200E, CYS202E, CYS226E, CYS259D, CYS271D, CYS27E, CYS374E, CYS380D, CYS396E, CYS417E, CYS62D, CYS63D, CYS68D, CYS94D, CYS96D, GLN102D, GLN10D, GLN152E, GLN225E, GLN299E, GLN341E, GLN392D, GLN396D, GLN439D, GLN48E, GLN66D, GLU128E, GLU166E, GLU173E, GLU183D, GLU199E, GLU201E, GLU224E, GLU241D, GLU260D, GLU269D, GLU303E, GLU309E, GLU323E, GLU327E, GLU342E, GLU34E, GLU354E, GLU67D, GLU99D, GLY135E, GLY162E, GLY171E, GLY182D, GLY227D, GLY258D, GLY279E, GLY325E, GLY331E, GLY346E, GLY350E, GLY370E, GLY40E, GLY415D, GLY416D, GLY424D, GLY54D, GLY64D, GLY72E, GLY90D, GLY91D, HIS118D, HIS168E, HIS230D, HIS256E, HIS28E, HIS305E, HIS308E, HIS349E, HIS353E, HIS362D, HIS381D, HIS386D, HIS390D, HIS394D, HIS41E, HIS50D, HIS71E, ILE13D, ILE229D, ILE261D, ILE276E, ILE296E, ILE356E, ILE361D, ILE373E, ILE377E, ILE387D, ILE420D, ILE421D, ILE422D, ILE423D, ILE60D, LEU115D, LEU169E, LEU178E, LEU197E, LEU243E, LEU251D, LEU255E, LEU260E, LEU261E, LEU295E, LEU300E, LEU351E, LEU371E, LEU388E, LEU410D, LEU413D, LEU414D, LEU415E, LEU425D, LEU427D, LEU436D, LYS105D, LYS110D, LYS130E, LYS222E, LYS223E, LYS225D, LYS242E, LYS244D, LYS245D, LYS245E, LYS247D, LYS252D, LYS252E, LYS254E, LYS324E, LYS336E, LYS37E, LYS384D, LYS404D, LYS52D, LYS61D, MET109D, MET16E, MET55D, MET70E, MET88D, PHE131E, PHE240D, PHE253D, PHE257D, PHE259E, PHE278E, PHE280E, PHE338E, PHE389E, PHE398D, PHE87D, PHE95D, PHE99E, PRO133E, PRO170E, PRO224D, PRO232D, PRO244E, PRO249D, PRO256D, PRO304E, PRO30E, PRO335E, PRO348E, PRO352E, PRO382D, PRO383D, PRO391D, PRO399E, PRO58D, PRO86D, SER104D, SER111D, SER172E, SER176E, SER177E, SER211D, SER240E, SER250D, SER26E, SER282E, SER29E, SER309D, SER310D, SER381E, SER385E, SER38E, SER392E, SER403D, SER417D, SER57D, THR250E, THR254D, THR263D, THR277E, THR297E, THR307E, THR343E, THR357E, THR367E, THR379E, THR386E, THR389D, THR398E, THR405D, THR408D, THR411D, THR429D, THR53D, THR69D, THR73E, TRP170D, TRP326E, TRP339E, TRP387E, TRP407D, TRP409D, TRP89D, TYR107D, TYR127E, TYR154E, TYR164E, TYR180D, TYR229E, TYR233D, TYR238E, TYR262D, TYR294E, TYR306E, TYR308D, TYR359E, TYR363E, TYR393D, TYR434D, TYR51D, TYR93D, VAL103D, VAL134E, VAL153E, VAL165E, VAL174E, VAL179E, VAL231D, VAL237E, VAL257E, VAL273D, VAL283E, VAL307D, VAL321E, VAL329E, VAL355E, VAL380E, VAL382E, VAL388D, VAL394E, VAL402D, VAL419D, VAL426D, VAL431D, VAL435D
• D-F: ALA432D, ARG213F, ASN211F, ASN259F, ASN438D, ASN442D, GLN439D, GLU260F, GLY212F, GLY262F, HIS441D, LEU436D, LYS172F, LYS195F, LYS261F, LYS266F, LYS440D, MET257F, THR264F, THR437D, TRP258F, TYR173F, TYR191F, TYR209F, TYR267F, TYR434D, VAL255F, VAL256F, VAL263F, VAL265F, VAL435D
• D-H: ALA199D, ALA226D, ALA228D, ALA236D, ALA271H, ARG223D, ASN216D, ASN218D, ASN291H, ASP246D, CYS266H, GLN196D, GLN222D, GLN235D, GLN242D, GLU144H, GLU148H, GLU273H, GLU313H, GLY146H, GLY198D, GLY239D, HIS145H, HIS230D, HIS288H, HIS333H, ILE229D, ILE276H, LEU221D, LEU270H, LEU287H, LYS225D, LYS245D, LYS265H, LYS286H, LYS290H, MET275H, MET55D, PRO197D, PRO224D, PRO232D, PRO237D, PRO272H, PRO274H, PRO289H, PRO314H, SER238D, THR217D, THR234D, THR267H, TYR233D, VAL147H, VAL220D, VAL231D, VAL268H, VAL316H
• E-F: ALA170F, ALA178F, ALA239F, ALA395E, ALA406E, ALA421E, ARG149F, ARG185F, ARG391E, ARG401E, ARG407E, ARG419E, ARG422E, ASN259F, ASN405E, ASP174F, ASP179F, CYS141F, CYS411E, GLN182F, GLU176F, GLY144F, GLY145F, GLY227F, GLY262F, HIS193F, ILE240F, ILE408E, LEU147F, LEU175F, LEU242F, LEU397E, LEU402E, LYS146F, LYS168F, LYS169F, LYS172F, LYS190F, LYS261F, LYS266F, MET257F, PHE148F, PHE189F, PHE410E, PRO150F, PRO399E, PRO404E, SER171F, THR188F, THR192F, THR264F, THR398E, THR403E, TRP258F, TYR173F, TYR177F, TYR191F, TYR400E, VAL142F, VAL143F, VAL180F, VAL237F, VAL238F, VAL256F, VAL263F, VAL265F, VAL394E
• E-H: ALA102H, ALA106E, ALA23E, ARG103H, ARG120E, ARG120H, ARG18E, ARG21E, ARG64H, ARG88E, ARG88H, ASP108E, ASP241E, ASP42H, ASP94H, CYS123E, CYS19E, CYS22E, CYS266H, CYS90H, GLN81E, GLN81H, GLU113E, GLU128E, GLU144H, GLY107E, GLY146H, GLY25E, GLY43H, HIS121E, HIS141H, HIS145H, HIS156H, HIS80H, HIS91H, ILE110E, ILE20E, ILE92H, LEU101H, LEU79H, LEU84H, LYS115E, LYS116E, LYS242E, LYS265H, LYS290H, MET112E, PHE114E, PRO105H, PRO126E, PRO142H, PRO143H, PRO89E, PRO89H, SER109E, SER118E, SER122E, SER124E, SER83H, SER87E, SER87H, THR111E, THR140H, THR267H, THR86E, TYR127E, TYR139H, TYR44H, TYR85E, TYR85H, VAL119E, VAL125E, VAL24E, VAL268H, VAL82H, VAL93H
• E-J: ALA199J, ALA228J, ALA236J, ALA271E, ALA315E, ARG223J, ASN216J, ASN218J, ASP246J, GLN196J, GLN222J, GLN235J, GLN242J, GLU144E, GLU148E, GLU273E, GLU313E, GLY146E, GLY198J, GLY239J, HIS145E, HIS230J, HIS288E, HIS333E, ILE229J, ILE276E, LEU270E, LEU287E, LYS225J, LYS245J, LYS286E, LYS290E, MET275E, MET55J, PHE200J, PRO143E, PRO197J, PRO224J, PRO232J, PRO237J, PRO272E, PRO274E, PRO289E, PRO314E, SER238J, THR217J, THR234J, THR267E, TYR233J, VAL147E, VAL220J, VAL231J, VAL268E, VAL316E
• E-K: ALA106K, ALA23K, ARG103E, ARG120E, ARG120K, ARG18K, ARG21K, ARG64E, ARG88E, ARG88K, ASP108K, ASP241K, ASP42E, ASP94E, CYS123K, CYS19K, CYS22K, CYS266E, CYS90E, GLN81E, GLU113K, GLU128K, GLU144E, GLY107K, GLY25K, GLY43E, HIS121K, HIS141E, HIS145E, HIS156E, HIS80E, HIS91E, ILE110K, ILE20K, ILE31K, ILE92E, LYS242K, LYS290E, MET112K, PRO105E, PRO105K, PRO126K, PRO142E, PRO143E, PRO89E, PRO89K, SER109K, SER118K, SER122K, SER124K, SER26K, SER83E, SER87E, SER87K, THR111K, THR140E, THR267E, THR86K, TYR127K, TYR139E, TYR44E, TYR85E, TYR85K, VAL119K, VAL125K, VAL24K, VAL93E
• F-I: ASN159I, ASP158I, ASP160I, GLU133F, GLU133I, GLY134I, ILE157I, LYS135F, LYS156I, MET131I
• F-L: ALA163F, ALA164F, ASN159F, ASP158F, ASP160F, GLU133F, GLU133L, GLY134F, GLY134L, GLY155F, ILE157F, LEU132F, LYS135L, LYS156F, LYS223L, MET131F
• G-H: ALA106G, ALA116G, ALA150H, ALA163H, ALA17H, ALA181G, ALA228G, ALA228H, ALA246H, ALA247H, ALA248G, ALA255G, ALA262H, ALA272G, ALA301H, ALA340H, ALA344H, ALA35H, ALA375H, ALA376H, ALA378H, ALA383H, ALA384H, ALA395H, ALA400G, ALA401G, ALA406G, ALA418G, ALA428G, ALA432G, ALA59G, ALA92G, ARG136H, ARG161H, ARG18H, ARG21H, ARG227H, ARG230H, ARG281H, ARG298H, ARG337H, ARG362H, ARG391H, ARG46H, ARG73G, ASN100G, ASN132H, ASN239H, ASN270G, ASN332H, ASN347H, ASN438G, ASP112G, ASP113G, ASP117G, ASP175H, ASP241H, ASP263H, ASP302H, ASP379G, ASP385G, ASP39H, ASP56G, ASP69H, CYS114G, CYS151H, CYS200H, CYS202H, CYS226H, CYS259G, CYS271G, CYS27H, CYS374H, CYS396H, CYS62G, CYS63G, CYS68G, CYS94G, CYS96G, GLN102G, GLN10G, GLN152H, GLN225H, GLN299H, GLN341H, GLN392G, GLN396G, GLN439G, GLN48H, GLN66G, GLU128H, GLU166H, GLU173H, GLU183G, GLU199H, GLU201H, GLU224H, GLU241G, GLU260G, GLU269G, GLU303H, GLU323H, GLU327H, GLU342H, GLU34H, GLU67G, GLY135H, GLY162H, GLY171H, GLY182G, GLY227G, GLY258G, GLY279H, GLY325H, GLY331H, GLY350H, GLY370H, GLY40H, GLY415G, GLY416G, GLY424G, GLY54G, GLY64G, GLY72H, GLY90G, GLY91G, HIS118G, HIS168H, HIS230G, HIS256H, HIS28H, HIS305H, HIS308H, HIS349H, HIS353H, HIS362G, HIS386G, HIS390G, HIS394G, HIS41H, HIS50G, HIS71H, ILE13G, ILE20H, ILE229G, ILE261G, ILE276H, ILE296H, ILE356H, ILE361G, ILE373H, ILE377H, ILE387G, ILE420G, ILE421G, ILE422G, ILE423G, ILE60G, LEU115G, LEU169H, LEU178H, LEU197H, LEU243H, LEU251G, LEU260H, LEU261H, LEU295H, LEU300H, LEU351H, LEU371H, LEU388H, LEU410G, LEU413G, LEU414G, LEU415H, LEU425G, LEU427G, LYS105G, LYS110G, LYS130H, LYS222H, LYS223H, LYS225G, LYS242H, LYS244G, LYS245G, LYS245H, LYS247G, LYS252G, LYS252H, LYS254H, LYS324H, LYS336H, LYS37H, LYS384G, LYS404G, LYS52G, LYS61G, MET109G, MET16H, MET55G, MET70H, MET88G, PHE131H, PHE240G, PHE253G, PHE257G, PHE259H, PHE278H, PHE280H, PHE338H, PHE389H, PHE87G, PHE95G, PHE99H, PRO170H, PRO224G, PRO232G, PRO244H, PRO249G, PRO256G, PRO304H, PRO335H, PRO348H, PRO352H, PRO382G, PRO383G, PRO391G, PRO399H, PRO58G, PRO86G, SER104G, SER111G, SER172H, SER176H, SER177H, SER211G, SER240H, SER250G, SER26H, SER282H, SER29H, SER309G, SER310G, SER381H, SER385H, SER38H, SER392H, SER403G, SER417G, SER57G, THR250H, THR254G, THR277H, THR297H, THR307H, THR343H, THR379H, THR386H, THR389G, THR398H, THR405G, THR408G, THR411G, THR429G, THR53G, THR69G, THR71G, THR73H, TRP170G, TRP326H, TRP339H, TRP387H, TRP407G, TRP409G, TRP89G, TYR107G, TYR127H, TYR154H, TYR164H, TYR180G, TYR229H, TYR233G, TYR238H, TYR294H, TYR306H, TYR308G, TYR359H, TYR363H, TYR393G, TYR434G, TYR51G, TYR93G, VAL103G, VAL134H, VAL153H, VAL165H, VAL174H, VAL179H, VAL231G, VAL237H, VAL257H, VAL273G, VAL283H, VAL321H, VAL329H, VAL355H, VAL36H, VAL380H, VAL382H, VAL388G, VAL394H, VAL402G, VAL414H, VAL419G, VAL426G, VAL431G, VAL435G
• G-I: ALA432G, ASN211I, ASN259I, ASN438G, ASN442G, GLN439G, GLU260I, GLY212I, GLY262I, HIS441G, LEU436G, LYS172I, LYS195I, LYS261I, LYS266I, LYS440G, MET257I, THR264I, THR437G, TRP258I, TYR173I, TYR191I, TYR209I, TYR267I, TYR434G, VAL238I, VAL256I, VAL263I, VAL265I, VAL435G
• G-K: ALA199G, ALA228G, ALA236G, ALA271K, ALA315K, ARG223G, ASN216G, ASN218G, ASP246G, CYS266K, GLN196G, GLN222G, GLN235G, GLN242G, GLU144K, GLU148K, GLU241G, GLU273K, GLU313K, GLY146K, GLY198G, GLY239G, HIS145K, HIS230G, HIS288K, HIS333K, ILE276K, LEU270K, LEU287K, LYS225G, LYS245G, LYS265K, LYS286K, LYS290K, MET275K, MET55G, PRO143K, PRO197G, PRO224G, PRO232G, PRO237G, PRO269K, PRO272K, PRO274K, PRO289K, PRO314K, SER238G, THR217G, THR234G, THR267K, TYR233G, TYR51G, VAL147K, VAL220G, VAL231G, VAL268K
• H-I: ALA170I, ALA178I, ALA239I, ALA395H, ALA406H, ALA421H, ALA423H, ARG149I, ARG185I, ARG401H, ARG407H, ARG419H, ARG422H, ASN259I, ASN405H, ASP174I, ASP179I, CYS141I, CYS411H, GLN182I, GLU176I, GLU260I, GLY144I, GLY145I, GLY262I, HIS193I, ILE240I, ILE408H, LEU147I, LEU175I, LEU242I, LEU397H, LEU402H, LEU412H, LYS146I, LYS168I, LYS169I, LYS172I, LYS190I, LYS261I, LYS266I, MET257I, PHE148I, PHE189I, PHE410H, PRO150I, PRO181I, PRO399H, PRO404H, SER171I, THR188I, THR192I, THR264I, THR398H, THR403H, TRP258I, TYR173I, TYR177I, TYR191I, TYR400H, VAL142I, VAL143I, VAL180I, VAL237I, VAL256I, VAL263I, VAL265I, VAL394H
• H-K: ALA106H, ALA17H, ALA23H, ALA32H, ARG103K, ARG120H, ARG120K, ARG18H, ARG21H, ARG64K, ARG88H, ARG88K, ASP108H, ASP241H, ASP42K, ASP94K, CYS123H, CYS19H, CYS22H, CYS266K, CYS90K, GLN81K, GLU113H, GLU128H, GLU144K, GLU34H, GLY107H, GLY146K, GLY25H, HIS121H, HIS141K, HIS145K, HIS156K, HIS80K, HIS91K, ILE110H, ILE20H, ILE31H, ILE33H, ILE92K, LEU79K, LEU84K, LYS115H, LYS116H, LYS242H, LYS265K, LYS290K, MET112H, PHE114H, PRO105H, PRO105K, PRO126H, PRO142K, PRO143K, PRO78K, PRO89H, PRO89K, SER109H, SER118H, SER122H, SER124H, SER83K, SER87H, SER87K, THR111H, THR140K, THR267K, THR86H, TYR127H, TYR139K, TYR44K, TYR85H, TYR85K, VAL119H, VAL125H, VAL153K, VAL24H, VAL93K
• I-L: ALA163L, ASN137I, ASN159L, ASP158L, ASP160L, GLU133I, GLU133L, GLY134I, GLY134L, ILE157L, LEU132I, LEU132L, LYS135I, LYS156L, LYS223I, MET131L, PHE128L, PRO129L, VAL161L
• J-K: ALA106J, ALA116J, ALA150K, ALA163K, ALA17K, ALA181J, ALA226J, ALA228J, ALA228K, ALA246K, ALA247K, ALA248J, ALA255J, ALA262K, ALA272J, ALA301K, ALA340K, ALA344K, ALA359J, ALA35K, ALA375K, ALA376K, ALA378K, ALA383K, ALA384K, ALA395K, ALA400J, ALA401J, ALA406J, ALA418J, ALA428J, ALA432J, ALA59J, ALA92J, ARG136K, ARG18K, ARG227K, ARG230K, ARG281K, ARG298K, ARG337K, ARG362K, ARG391K, ARG401K, ARG46K, ARG73J, ASN132K, ASN239K, ASN270J, ASN347K, ASN438J, ASP112J, ASP113J, ASP117J, ASP175K, ASP241K, ASP263K, ASP302K, ASP311J, ASP379J, ASP385J, ASP39K, ASP56J, ASP69K, CYS114J, CYS151K, CYS200K, CYS202K, CYS226K, CYS259J, CYS271J, CYS27K, CYS374K, CYS380J, CYS396K, CYS411K, CYS417K, CYS62J, CYS63J, CYS68J, CYS94J, CYS96J, GLN102J, GLN10J, GLN152K, GLN225K, GLN299K, GLN341K, GLN392J, GLN396J, GLN439J, GLN48K, GLN66J, GLU128K, GLU166K, GLU173K, GLU183J, GLU199K, GLU201K, GLU224K, GLU241J, GLU260J, GLU269J, GLU303K, GLU309K, GLU323K, GLU327K, GLU342K, GLU34K, GLU67J, GLU99J, GLY135K, GLY162K, GLY171K, GLY227J, GLY258J, GLY279K, GLY325K, GLY331K, GLY346K, GLY350K, GLY370K, GLY40K, GLY415J, GLY416J, GLY424J, GLY54J, GLY64J, GLY72K, GLY90J, GLY91J, HIS118J, HIS168K, HIS230J, HIS256K, HIS28K, HIS305K, HIS308K, HIS349K, HIS353K, HIS362J, HIS381J, HIS386J, HIS390J, HIS394J, HIS41K, HIS50J, HIS71K, ILE13J, ILE229J, ILE261J, ILE276K, ILE296K, ILE356K, ILE361J, ILE373K, ILE377K, ILE387J, ILE420J, ILE421J, ILE422J, ILE423J, ILE60J, LEU115J, LEU169K, LEU178K, LEU197K, LEU231K, LEU243K, LEU251J, LEU260K, LEU261K, LEU295K, LEU300K, LEU351K, LEU371K, LEU388K, LEU397K, LEU410J, LEU413J, LEU414J, LEU415K, LEU425J, LEU427J, LEU436J, LYS105J, LYS110J, LYS130K, LYS222K, LYS223K, LYS225J, LYS242K, LYS244J, LYS245J, LYS245K, LYS247J, LYS252J, LYS252K, LYS254K, LYS324K, LYS336K, LYS37K, LYS384J, LYS404J, LYS52J, LYS61J, MET109J, MET16K, MET55J, MET70K, MET88J, PHE131K, PHE240J, PHE253J, PHE257J, PHE259K, PHE278K, PHE280K, PHE338K, PHE389K, PHE398J, PHE87J, PHE95J, PHE99K, PRO170K, PRO232J, PRO244K, PRO249J, PRO256J, PRO258K, PRO304K, PRO335K, PRO348K, PRO352K, PRO382J, PRO383J, PRO391J, PRO399K, PRO58J, PRO86J, SER104J, SER111J, SER172K, SER176K, SER177K, SER240K, SER250J, SER26K, SER282K, SER29K, SER309J, SER310J, SER381K, SER385K, SER38K, SER392K, SER403J, SER417J, SER57J, THR250K, THR254J, THR277K, THR297K, THR307K, THR343K, THR357K, THR379K, THR386K, THR389J, THR397J, THR398K, THR405J, THR411J, THR429J, THR53J, THR73K, TRP170J, TRP326K, TRP339K, TRP387K, TRP407J, TRP409J, TRP89J, TYR107J, TYR154K, TYR164K, TYR180J, TYR229K, TYR233J, TYR238K, TYR262J, TYR294K, TYR306K, TYR308J, TYR359K, TYR363K, TYR393J, TYR400K, TYR434J, TYR51J, TYR85J, TYR93J, VAL103J, VAL134K, VAL153K, VAL165K, VAL174K, VAL231J, VAL237K, VAL257K, VAL273J, VAL283K, VAL307J, VAL321K, VAL329K, VAL355K, VAL380K, VAL382K, VAL388J, VAL394K, VAL402J, VAL414K, VAL419J, VAL426J, VAL431J, VAL435J
• J-L: ALA432J, ASN211L, ASN259L, ASN438J, ASN442J, GLN439J, GLU260L, GLY212L, GLY262L, HIS193L, HIS441J, LEU436J, LYS172L, LYS195L, LYS261L, LYS266L, LYS440J, MET257L, THR264L, THR437J, TRP258L, TYR173L, TYR191L, TYR209L, TYR267L, TYR434J, VAL256L, VAL263L, VAL265L, VAL435J
• K-L: ALA170L, ALA178L, ALA239L, ALA395K, ALA406K, ALA421K, ARG149L, ARG185L, ARG391K, ARG401K, ARG407K, ARG419K, ARG422K, ASN259L, ASN405K, ASP174L, ASP179L, CYS141L, CYS411K, GLN182L, GLU176L, GLU260L, GLY144L, GLY145L, GLY227L, GLY262L, HIS193L, ILE240L, ILE408K, LEU147L, LEU175L, LEU242L, LEU397K, LEU402K, LEU412K, LYS146L, LYS168L, LYS169L, LYS172L, LYS190L, LYS261L, LYS266L, MET257L, PHE148L, PHE189L, PHE410K, PRO150L, PRO399K, PRO404K, SER171L, THR192L, THR264L, THR398K, THR403K, TRP258L, TYR173L, TYR177L, TYR191L, TYR400K, VAL142L, VAL143L, VAL180L, VAL237L, VAL256L, VAL263L, VAL265L, VAL394K