3IZS

localization of the large subunit ribosomal proteins into a 6.1 a cryo-em map of saccharomyces cerevisiae translating 80s ribosome

• Total interactions analyzed: 1275
• Total true interactions: 85
• Strongest Interaction:
  • Chains: B-H
  • Int. Res.: 30
  • Norm. En. per Res.: -3.9105
• Hub Node: F(8)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-k	0.0	4.5064	-13.6286	-9.1222	28	0	0	1314	0	7	12
B-H	-18.8681	-34.5543	-63.8913	-117.3136	30	2	0	2301	1	8	15
B-P	0.0	0.0	-9.7887	-9.7887	11	2	0	459	0	0	4
B-X	0.0	0.0	-13.8902	-13.8902	9	0	0	570	0	0	3
B-a	0.0	0.0	-2.2644	-2.2644	20	0	0	425	0	2	10
B-f	0.0	0.0	-0.1328	-0.1328	9	0	0	61	0	0	0
B-m	-51.6672	-3.0758	-294.768	-349.511	132	57	16	15197	0	17	28
B-x	-2.5374	0.0	-131.816	-134.3534	42	24	0	5531	0	0	0
C-K	0.0	-7.8001	-95.4746	-103.2747	55	4	0	4289	0	8	17
C-M	-7.4718	6.7339	-138.62	-139.3579	54	15	3	5363	0	23	32
C-Z	0.0	2.1763	-96.6283	-94.452	52	17	0	4065	0	9	19
C-g	0.0	0.0	-0.0316	-0.0316	2	0	0	12	0	0	2
E-r	0.0	0.0	-26.7163	-26.7163	14	1	0	875	0	0	0
E-Q	-13.2726	25.4983	-82.8868	-70.6611	35	7	0	3299	0	8	27
G-N	0.0	17.6469	-25.2219	-7.575	40	26	4	3972	0	13	18
G-V	0.0	0.0	-0.1436	-0.1436	3	0	0	40	0	0	0
G-h	0.0	1.2637	-32.4054	-31.1417	24	4	0	1690	0	0	11
G-j	0.0	-21.8963	-62.5461	-84.4424	39	7	0	2712	1	10	9
G-D	0.0	0.6809	0.0	0.6809	2	0	0	0	0	0	0
F-K	0.0	-0.796	-12.4688	-13.2648	17	2	0	930	0	4	17
F-N	-12.0315	12.3045	-95.9574	-95.6844	58	37	3	5715	1	8	14
F-d	0.0	0.0	-0.0005	-0.0005	2	0	0	1	0	0	0
F-z	0.0	0.0	-10.7799	-10.7799	27	0	0	1204	0	0	0
F-S	0.0	1.3964			5
H-P	-3.205	-10.4006	-230.892	-244.4975	85	9	10	9892	0	31	22
H-X	-11.2806	0.0	-86.8437	-98.1243	33	4	3	3598	0	2	12
H-k	0.0	-7.0336	-8.9445	-15.9781	32	5	0	1201	0	17	15
H-q	0.0	10.982	-64.4022	-53.4202	31	3	0	2412	0	7	28
H-x	0.0	0.0	-15.6016	-15.6016	13	1	0	1086	0	0	0
s-J	0.0	7.158	-42.2131	-35.0551	29	12	0	1752	0	7	10
s-t	0.0	0.0	291.099	291.099	58	81	16	7409	0	1	0
s-u	0.0	9.4018	-44.5372	-35.1354	53	47	13	6682	0	3	4
s-v	-116.485	28.1487	-23.5443	-111.8806	75	59	13	7766	0	14	17
s-w	0.0	-3.493	211.819	208.326	58	63	6	6842	0	4	1
K-N	-7.8007	-7.2438	-134.719	-149.7635	56	17	3	5680	1	15	13
K-j	-8.3793	-10.3725	-26.061	-44.8129	35	4	0	1571	2	6	9
N-j	-17.797	0.0	-11.3485	-29.1455	34	2	0	1229	0	6	2
N-S	-27.7283	2.5158			19
M-Z	-28.4123	-1.6453	201.812	171.7544	55	80	10	5924	0	12	9
P-O	0.0	0.0	-0.4641	-0.4641	4	0	0	69	0	0	1
P-c	0.0	-1.983	-71.4928	-73.4758	38	4	1	3810	0	19	20
P-k	-4.0432	8.7991	-134.991	-130.2352	43	16	1	5166	0	17	23
P-r	0.0	0.0	-11.2755	-11.2755	14	0	0	492	0	2	1
O-R	-4.4183	13.3134	-84.1526	-75.2576	50	3	0	3858	2	11	21
O-r	0.0	0.0	-0.0058	-0.0058	2	0	0	8	0	0	1
O-L	-16.0761	0.0			2
R-U	0.0	0.0	-0.4117	-0.4117	8	0	0	63	0	3	3
R-e	0.0	-17.1784	-53.1978	-70.3762	27	3	0	2026	1	4	7
R-D	-6.0409	-8.2595	50.9503	36.6499	41	24	1	2620	0	8	7
T-W	0.0	0.0	-0.0775	-0.0775	2	0	0	22	0	0	0
T-X	0.0	0.0	-0.1623	-0.1623	4	0	0	45	0	2	1
T-p	-2.7884	0.0	-19.3607	-22.1491	16	1	0	687	0	0	5
U-e	0.0	0.0	-12.9158	-12.9158	20	0	0	892	0	1	5
U-y	0.0	0.0	-1.7563	-1.7563	8	0	0	206	0	0	0
U-Q	0.0	1.5247	-84.8825	-83.3578	51	7	4	4247	0	6	16
V-g	0.0	9.9577	-0.206	9.7517	6	0	0	27	0	2	6
V-j	0.0	0.0	-8.0752	-8.0752	5	0	0	284	0	0	0
V-o	0.0	0.0	-1.2918	-1.2918	5	0	0	115	0	0	3
V-D	0.0	0.0	-0.1128	-0.1128	6	0	0	35	0	0	3
X-c	-3.6475	17.199	-95.2829	-81.7314	65	4	3	5004	0	15	20
X-o	0.0	3.7351	-41.0342	-37.2991	20	3	0	1986	0	0	10
Y-l	0.0	0.0	-0.002	-0.002	3	0	0	2	0	0	0
Y-o	0.0	0.0	-0.0673	-0.0673	7	0	0	31	0	0	2
Y-D	-3.4595	35.074	0.0	31.6145	7	0	0	0	0	0	0
a-f	0.0	-5.4536	-88.5308	-93.9844	36	7	3	3898	0	7	7
a-i	-14.2251	28.1362	26.2136	40.1247	64	61	0	6698	0	7	22
a-m	0.0	2.5564	-1.5943	0.962	11	0	0	280	0	0	7
a-p	0.0	0.0	-0.0004	-0.0004	2	0	0	1	0	0	1
a-x	0.0	0.0	-12.3865	-12.3865	21	3	0	889	0	0	0
d-z	0.0	0.0	-0.0375	-0.0375	3	0	0	7	0	0	0
c-l	0.0	5.82	-22.0231	-16.2031	28	2	0	1084	0	0	14
c-o	0.0	0.0	-0.1139	-0.1139	2	0	0	21	0	0	0
f-i	-68.1043	-3.3238	541.159	469.7308	40	67	1	3185	0	7	8
f-m	0.0	6.9206	-36.8559	-29.9353	30	0	0	1892	0	2	9
f-x	0.0	0.0	-10.294	-10.294	10	3	0	465	0	0	0
e-D	-10.9688	7.9851	0.0	-2.9837	18	0	0	0	0	0	0
e-S	-29.7029	37.8384			13
h-j	0.0	0.0	-0.6949	-0.6949	10	0	0	112	0	0	2
i-x	0.0	0.0	-0.6656	-0.6656	11	0	0	169	0	0	0
l-o	0.0	0.0	-24.4519	-24.4519	24	0	1	1543	0	0	15
l-D	0.0	2.0711	-8.8421	-6.771	13	1	0	538	0	1	6
t-u	0.0	0.0	-0.0908	-0.0908	8	0	0	30	0	3	3
t-v	-4.3022	-5.6349	-16.3059	-26.243	60	89	24	8356	0	4	4
t-w	-17.581	38.1073	418.46	438.9863	34	77	0	3801	1	8	14
u-w	-9.3809	-6.3201	400.54	384.839	66	128	24	9217	0	4	7

Interface residues

• A-k: ALA33k, ARG10A, ARG215A, ARG41k, ARG62k, ARG70k, GLN199A, GLN8A, GLU11A, GLY202A, HIS12A, ILE4A, LYS29k, LYS30k, LYS38k, LYS3A, LYS67k, SER203A, SER27k, SER34k, SER6A, SER7A, THR37k, THR5A, TRP198A, TYR28k, TYR41A, VAL9A
• B-H: ALA35B, ARG30B, ARG37B, ARG42B, ARG60H, ARG64B, ARG70B, ARG72B, ASP33B, ASP65B, GLN61H, GLU36B, GLY39B, ILE41B, ILE64H, LEU32B, LEU65H, LEU71B, LYS62H, LYS68B, LYS70H, PHE63B, PRO66B, PRO72H, THR31B, TYR34B, TYR40B, TYR67B, TYR69B, VAL71H
• B-P: ARG3B, ARG9B, ASN7B, GLN8B, GLY11B, GLY232B, ILE5B, LYS77P, SER231B, VAL230B, VAL4B
• B-X: ARG70B, LEU34X, LEU38X, LYS36X, LYS68B, PRO35X, THR37X, TYR67B, TYR69B
• B-a: ARG17a, ARG42B, ARG64B, ARG84a, ASN76a, GLN47B, HIS38B, HIS79a, ILE44B, ILE72a, LEU80a, LEU87a, LYS46B, LYS60B, LYS64a, LYS73a, PHE87B, THR83a, TYR18a, VAL62B
• B-f: ASN47f, GLN86B, GLY85B, HIS83B, ILE44B, LEU51f, PHE87B, PRO49f, VAL50f
• B-m: ALA170B, ALA182B, ALA51m, ALA52m, ALA56B, ALA59B, ALA65m, ALA68m, ALA75m, ALA76m, ALA77m, ALA78B, ARG174B, ARG184B, ARG23m, ARG24m, ARG49m, ARG80m, ARG84m, ARG85m, ARG87m, ASN100B, ASN79B, ASN97B, ASP176B, ASP51B, CYS39m, CYS57m, CYS60m, GLN25m, GLN32m, GLN33m, GLN47B, GLN86B, GLU109B, GLU30m, GLU80B, GLU88m, GLU91m, GLY110B, GLY12m, GLY131B, GLY15m, GLY167B, GLY171B, GLY172B, GLY173B, GLY183B, GLY19m, GLY50m, GLY53m, GLY55B, GLY66m, GLY67m, GLY81B, GLY85B, GLY99B, HIS139B, HIS34m, HIS50B, HIS83B, ILE10m, ILE112B, ILE135B, ILE136B, ILE166B, ILE169B, ILE31m, ILE44B, ILE48B, ILE54m, ILE83m, LEU179B, LEU180B, LEU22m, LEU29m, LEU58B, LEU86m, LEU96B, LYS13m, LYS177B, LYS181B, LYS188B, LYS27m, LYS28m, LYS46B, LYS60B, LYS61m, LYS62m, MET89m, PHE41m, PHE87B, PRO108B, PRO178B, PRO57B, SER106B, SER114B, SER130B, SER21m, SER40m, SER72m, SER81m, SER95B, THR111B, THR11m, THR56m, THR63m, THR70m, THR73m, THR78m, THR82m, THR84B, TRP55m, TYR133B, TYR14m, TYR18m, TYR37m, TYR69m, VAL107B, VAL113B, VAL134B, VAL168B, VAL175B, VAL26m, VAL45B, VAL49B, VAL64m, VAL71m, VAL79m, VAL82B, VAL90m, VAL98B
• B-x: ALA35B, ALA94B, ARG37B, ARG42B, ASN100B, ASN97B, ASP33B, ASP65B, GLN86B, GLU36B, GLY39B, GLY85B, HIS38B, ILE41B, ILE44B, ILE88B, LEU96B, LYS93B, PHE87B, PRO66B, SER95B, TYR34B, TYR40B, TYR67B, TYR89B, UNK10x, UNK11x, UNK12x, UNK13x, UNK14x, UNK15x, UNK16x, UNK17x, UNK1x, UNK2x, UNK3x, UNK4x, UNK5x, UNK6x, UNK7x, UNK8x, UNK9x
• C-K: ALA154K, ALA155C, ALA158K, ALA31C, ALA38K, ALA63K, ARG100C, ARG10C, ARG37K, ARG68K, ARG97C, ASN65K, ASP151K, GLU106K, GLU150K, GLU157K, GLU39K, GLU94C, GLY107K, GLY98C, HIS259C, ILE108K, LEU156K, LEU17C, LEU99C, LYS148K, LYS155K, LYS159K, LYS30C, LYS66K, MET261C, PHE105K, PHE64K, PRO109K, PRO110K, PRO18C, PRO257C, PRO96C, SER263C, SER77K, THR67K, THR95C, TRP147K, TRP262C, TYR112K, TYR149K, TYR154C, VAL104K, VAL152K, VAL153K, VAL162K, VAL260C, VAL264C, VAL36K, VAL93C
• C-M: ALA123M, ALA75C, ALA8C, ARG10C, ARG45M, ARG48M, ARG4C, ARG62C, ARG70C, ARG86M, ARG87M, ARG88M, ASN47M, ASP124M, ASP59C, ASP61C, ASP89M, CYS122M, GLU121M, GLU71C, GLU74C, GLU7C, GLY119M, GLY12C, GLY64C, GLY8M, GLY90M, HIS11C, HIS68C, LEU125M, LEU46M, LEU60C, LYS10M, LYS120M, LYS236C, LYS281C, LYS5C, LYS66C, LYS69C, PHE11M, PHE67C, PRO63C, PRO9C, SER44M, SER65C, THR55C, THR9M, TRP85M, TYR6C, VAL354C, VAL57C, VAL72C, VAL73C, VAL91M
• C-Z: ALA11Z, ALA362C, ARG17Z, ARG300C, ARG369C, ARG56Z, ARG70C, ASN33Z, ASP299C, ASP360C, GLN32Z, GLU4Z, GLU71C, GLY16Z, GLY366C, GLY368C, HIS377C, ILE13Z, ILE359C, ILE56C, LYS12Z, LYS2Z, LYS303C, LYS357C, LYS35Z, LYS364C, LYS367C, LYS376C, LYS57Z, MET1Z, MET380C, PHE298C, PHE365C, PHE370C, PRO15Z, PRO373C, SER297C, SER34Z, SER363C, SER9Z, THR301C, THR361C, THR372C, THR55C, TRP358C, TRP51Z, TYR14Z, VAL3Z, VAL53Z, VAL57C, VAL72C, VAL73C
• C-g: HIS313C, LYS18g
• E-r: ALA103r, ARG60E, ARG61E, ASN62E, GLN102r, GLN105r, GLU63E, ILE59E, ILE65E, LEU104r, LEU30E, LYS49E, LYS64E, PHE106r
• E-Q: ALA2Q, ARG137E, ARG141E, ARG143E, ARG152Q, ARG15Q, ARG21Q, ARG22Q, ARG23Q, ARG24Q, ARG50Q, ARG54Q, ASN150E, ASN57Q, CYS144E, GLN151Q, GLU25Q, GLY146E, GLY149Q, GLY26Q, LEU150Q, LEU51Q, LYS142E, LYS145E, LYS27Q, LYS5Q, MET1Q, PHE55Q, THR147E, THR28Q, THR56Q, TYR49Q, VAL138E, VAL52Q, VAL53Q
• G-N: ALA111N, ALA132G, ALA144G, ALA147G, ALA86G, ARG117N, ARG134G, ASN127G, ASP114N, ASP137G, ASP142G, GLN119N, GLN138G, GLU116N, GLU129G, GLU133G, GLU136G, GLU148G, ILE130G, ILE146G, ILE149G, ILE85G, LEU112N, LEU123N, LEU145G, LEU43G, LYS128G, LYS131G, LYS139G, LYS143G, MET121N, PHE115N, PHE118N, THR113N, VAL120N, VAL122N, VAL135G, VAL140G, VAL141G, VAL35G
• G-V: LYS175G, SER170V, THR169V
• G-h: ALA2h, ALA6G, GLN4G, GLY70h, HIS71h, HIS88h, LEU66h, LYS5G, LYS62h, LYS72h, LYS8G, LYS90h, MET1G, MET1h, MET87h, PRO11G, PRO7G, SER12G, THR84h, THR89h, THR91h, TRP9G, TYR10G, TYR92h
• G-j: ALA144G, ALA83j, ARG73j, ARG78G, ARG82j, ASN61G, ASN77j, ASN80G, ASP142G, ASP60G, GLN17j, GLN42j, GLU59G, GLY76j, GLY79j, HIS57G, HIS75j, ILE30j, LEU145G, LEU14j, LEU29j, LEU58G, LEU63G, LYS12j, LYS139G, LYS143G, LYS29G, LYS31j, PRO38j, SER15j, SER28j, SER78j, THR62G, THR74j, VAL140G, VAL141G, VAL27j, VAL80j, VAL81j
• G-D: LYS20G, LYS332D
• F-K: ARG128K, ARG133K, ASN59F, ASP42F, GLY132K, GLY61F, HIS40F, HIS58F, HIS64F, ILE41F, LEU129K, LYS130K, LYS134K, LYS39F, LYS63F, PRO131K, TYR135K
• F-N: ALA56F, ALA9N, ARG13N, ARG23F, ASN11N, ASN49F, ASN50F, ASN59F, ASP40N, ASP4N, GLN41N, GLN51F, GLN5F, GLN9F, GLU14F, GLU7F, GLY60F, HIS58F, ILE20F, ILE24F, ILE4F, ILE53F, ILE6N, LEU38F, LEU52F, LEU65N, LYS21F, LYS2F, LYS39F, LYS42N, LYS47F, LYS54F, LYS8N, MET1F, MET1N, PHE45F, SER10N, SER19F, SER22F, SER2N, SER5N, THR17F, THR3N, THR44F, THR46F, THR6F, TRP12N, TYR3F, VAL12F, VAL15N, VAL18F, VAL25F, VAL43F, VAL48F, VAL55F, VAL57F, VAL71F, VAL7N
• F-d: ARG173F, HIS43d
• F-z: ALA95F, ARG166F, ARG173F, ARG91F, GLN162F, ILE172F, LEU176F, LYS174F, SER182F, TYR180F, TYR94F, UNK10z, UNK11z, UNK12z, UNK13z, UNK14z, UNK1z, UNK2z, UNK3z, UNK4z, UNK5z, UNK6z, UNK7z, UNK8z, UNK9z, VAL181F, VAL93F
• F-S: ARG159S, ARG163S, ASP42F, HIS58F, LYS164S
• H-P: ALA141H, ALA168H, ALA3P, ALA76H, ALA87H, ALA88H, ARG20P, ARG24P, ARG26P, ARG31P, ARG41P, ARG44P, ARG49P, ARG63P, ARG84H, ASN137H, ASN34P, ASN85H, ASP158H, ASP17P, ASP46P, ASP83H, GLN11P, GLN15P, GLN23P, GLN32P, GLN77H, GLN79H, GLU144H, GLU161H, GLU228H, GLU29P, GLU89H, GLU8P, GLY234H, GLY2P, HIS138H, HIS37P, ILE160H, ILE75H, LEU10P, LEU136H, LEU162H, LEU166H, LEU169H, LEU19P, LEU22P, LEU7P, LEU82H, LEU93H, LYS172H, LYS183H, LYS230H, LYS33P, LYS5P, LYS92H, MET1P, PHE165H, PHE21P, PHE78H, PHE91H, PHE94H, PRO159H, PRO167H, PRO42P, PRO45P, SER16P, THR194H, THR43P, THR81H, THR86H, THR90H, TRP28P, TYR30P, TYR4P, TYR6P, TYR80H, VAL139H, VAL140H, VAL157H, VAL163H, VAL164H, VAL18P, VAL25P, VAL27P
• H-X: ALA23X, ALA30X, ARG27X, ARG33X, ARG60H, ARG68H, GLU100H, ILE64H, ILE67H, ILE75H, LEU34X, LEU65H, LEU69H, LEU82H, LYS181H, LYS21X, LYS22X, LYS25X, LYS36X, LYS39X, LYS63H, LYS70H, PHE32X, PRO35X, PRO72H, PRO73H, SER29X, SER66H, THR28X, THR31X, THR37X, THR74H, VAL71H
• H-k: ALA168H, ALA83k, ALA85k, ALA96k, ASN145H, ASN91k, ASN92k, ASP227H, GLU144H, GLU228H, GLU88k, GLU89k, HIS100k, ILE93k, ILE94k, LEU169H, LEU93H, LYS172H, LYS25k, LYS84k, LYS86k, LYS92H, MET173H, MET90k, PHE165H, PHE80k, PHE91H, THR81k, TYR226H, VAL140H, VAL164H, VAL87k
• H-q: ALA114H, ALA125H, ALA22q, ALA3q, ARG11q, ARG12q, ARG15q, ARG18q, ARG21q, ARG23q, ARG2q, ASN191H, ASP124H, GLN123H, GLN192H, LYS111H, LYS120H, LYS122H, LYS193H, LYS19q, LYS25q, LYS7q, LYS8q, MET1q, SER121H, SER126H, SER24q, THR10q, THR194H, TYR130H, TYR134H
• H-x: ARG60H, GLN61H, LYS62H, LYS63H, UNK10x, UNK11x, UNK12x, UNK13x, UNK14x, UNK15x, UNK16x, UNK17x, UNK9x
• s-J: ALA49s, ARG117J, ARG123J, ARG42s, ARG46s, ARG48s, ASP118J, GLN36s, GLN37s, GLU40s, GLU44s, GLY122J, GLY47s, HIS39s, LEU45s, LEU52s, LYS119J, LYS43s, MET38s, PHE121J, SER120J, SER35s, THR124J, TYR12J, TYR18s, TYR22s, VAL41s, VAL50s, VAL51s
• s-t: ALA10t, ALA11t, ALA15t, ALA216s, ALA221s, ALA226s, ALA42t, ALA46t, ALA48t, ALA6t, ASN241s, ASN53t, ASN60t, ASP16t, ASP43t, ASP50t, ASP56t, GLN52t, GLY228s, HIS237s, ILE13t, ILE21t, ILE220s, ILE223s, ILE227s, ILE40t, ILE44t, LEU12t, LEU225s, LEU232s, LEU49t, LEU54t, LEU57t, LEU58t, LEU7t, LYS244s, LYS47t, LYS55t, PHE213s, PHE45t, PHE61t, PRO230s, PRO233s, SER215s, SER218s, SER222s, SER224s, SER234s, SER5t, SER62t, SER8t, THR219s, THR231s, TRP41t, TYR229s, TYR9t, VAL217s, VAL59t
• s-u: ALA10u, ALA11u, ALA248s, ALA250s, ALA252s, ALA253s, ALA42u, ALA46u, ALA48u, ALA6u, ASN241s, ASN242s, ASN53u, ASN60u, ASP16u, ASP245s, ASP43u, ASP50u, ASP56u, GLN52u, GLU38u, HIS256s, ILE13u, ILE21u, ILE240s, ILE251s, ILE40u, ILE44u, LEU12u, LEU239s, LEU246s, LEU247s, LEU49u, LEU54u, LEU57u, LEU58u, LEU7u, LYS244s, LYS47u, LYS55u, PHE45u, PHE61u, SER254s, SER5u, SER62u, SER8u, TRP41u, TYR243s, TYR255s, TYR257s, TYR9u, VAL249s, VAL59u
• s-v: ALA12v, ALA216s, ALA221s, ALA44v, ALA5v, ALA6v, ASN11v, ASN193s, ASN58v, ASN98s, ASP18v, ASP192s, ASP203s, ASP206s, ASP35v, ASP51v, GLN195s, GLU207s, GLU208s, GLU34v, GLU36v, GLU46v, GLU52v, GLU56v, GLU95s, GLY194s, GLY57v, HIS212s, ILE201s, ILE204s, ILE220s, ILE33v, ILE54v, ILE96s, LEU202s, LEU209s, LEU42v, LEU45v, LEU4v, LEU53v, LEU76s, LEU8v, LEU93s, LEU9v, LYS23v, LYS37v, LYS48v, LYS97s, MET1v, PHE197s, PHE213s, PRO198s, PRO233s, PRO92s, SER200s, SER211s, SER215s, SER218s, SER39v, SER40v, SER43v, THR205s, THR219s, THR231s, THR55v, THR94s, TYR3v, TYR7v, VAL196s, VAL210s, VAL214s, VAL217s, VAL38v, VAL41v, VAL50v
• s-w: ALA12w, ALA226s, ALA44w, ALA5w, ALA6w, ASN11w, ASN241s, ASN242s, ASN58w, ASP245s, ASP51w, GLU34w, GLU36w, GLU46w, GLU52w, GLU56w, GLY228s, GLY236s, GLY57w, HIS237s, ILE227s, ILE240s, ILE54w, LEU225s, LEU232s, LEU239s, LEU246s, LEU247s, LEU42w, LEU45w, LEU4w, LEU53w, LEU8w, LEU9w, LYS244s, LYS2w, LYS37w, LYS48w, MET1w, PRO230s, PRO233s, SER224s, SER234s, SER39w, SER40w, SER43w, SER49w, THR231s, THR238s, THR55w, TYR229s, TYR243s, TYR3w, TYR7w, VAL235s, VAL38w, VAL41w, VAL50w
• K-N: ALA104N, ALA110N, ALA111N, ALA134N, ALA136N, ALA179K, ALA181K, ALA185K, ALA186K, ALA191K, ALA195K, ALA196K, ARG106N, ARG108N, ARG109N, ARG117N, ARG124N, ARG128N, ASN182K, ASP114N, ASP189K, GLN105N, GLN119N, GLN193K, GLN62N, GLU107N, GLU116N, GLU187K, GLY198K, LEU112N, LEU123N, LEU135N, LEU194K, LEU197K, LYS125N, LYS127N, LYS132N, LYS176K, LYS177K, LYS192K, MET121N, PHE118N, PHE174K, SER180K, SER188K, THR113N, THR130N, THR175K, THR184K, TYR199K, VAL120N, VAL122N, VAL126K, VAL131N, VAL178K, VAL190K
• K-j: ALA2j, ALA50j, ARG117K, ARG48j, ARG65j, ARG86j, ARG94K, ASN29K, ASN87j, ASN88j, GLN26K, GLN31K, GLU4K, GLY30K, GLY46j, GLY69j, HIS5j, ILE64j, LEU28K, LEU45j, LYS25K, LYS70j, MET1K, MET1j, MET67j, PRO121K, SER2K, THR72j, TRP68j, TYR44j, VAL120K, VAL22K, VAL3K, VAL66j, VAL71j
• N-j: ALA100N, ALA110N, ALA111N, ALA29N, ALA2j, ARG106N, ARG108N, ARG109N, ARG6j, ASP40j, GLN39j, GLN42j, GLU3j, GLY26N, GLY30N, HIS5j, ILE103N, ILE23N, LEU112N, LEU22N, LYS101N, LYS102N, LYS24N, LYS25N, LYS31N, MET121N, MET1j, PHE118N, PHE43j, PRO38j, SER28N, THR113N, THR37j, TYR44j
• N-S: ARG13N, ARG159S, ARG163S, ARG74N, ARG97S, ASN11N, ASP148S, ASP40N, ASP98S, GLU16N, HIS145S, ILE38N, LYS142S, LYS157S, LYS42N, LYS43N, THR167S, VAL158S, VAL15N
• M-Z: ALA37Z, ALA82M, ARG17Z, ARG23Z, ARG30Z, ARG80M, ARG86M, ARG87M, ASN24M, ASN33Z, ASP25Z, ASP89M, ASP97M, GLN32Z, GLN81M, GLU4Z, GLU96M, GLY116M, GLY119M, GLY134M, GLY16Z, GLY18Z, GLY24Z, GLY90M, ILE13Z, ILE28Z, LEU20Z, LEU54M, LEU93M, LYS27Z, LYS41Z, LYS83M, PHE21Z, PHE29Z, PHE31Z, PHE40Z, PHE92M, PHE95M, PRO117M, PRO15Z, SER26Z, SER34Z, SER84M, THR115M, THR19Z, TRP85M, TYR14Z, TYR94M, VAL118M, VAL135M, VAL136M, VAL137M, VAL22Z, VAL79M, VAL91M
• P-O: ALA35O, GLY36O, GLY37O, LYS179P
• P-c: ALA141P, ALA146P, ALA87c, ALA91c, ALA97c, ARG105c, ARG114P, ARG143P, ARG144P, ARG147P, ARG90c, ASN149P, ASP136P, ASP145P, ASP153P, CYS152P, GLN104c, GLN138P, GLN99c, GLU102c, GLU96c, HIS139P, ILE142P, ILE151P, LEU88c, LEU92c, LYS103c, LYS140P, LYS157P, LYS94c, PHE95c, PRO137P, PRO154P, THR101c, THR93c, TRP150P, VAL100c, VAL155P
• P-k: ALA3P, ALA83k, ALA85k, ALA95k, ALA96k, ARG12P, ARG20P, ARG50P, ARG82k, ARG98k, ARG99k, ASN91k, ASN92k, ASP17P, GLN11P, GLN15P, GLU88k, GLU89k, GLU8P, GLU9P, GLY2P, GLY78k, ILE93k, ILE94k, LEU10P, LEU19P, LEU7P, LYS13P, LYS14P, LYS5P, LYS84k, LYS86k, MET1P, MET90k, PHE80k, SER16P, SER79k, SER97k, THR81k, TYR4P, TYR6P, VAL18P, VAL87k
• P-r: ARG45r, GLN47r, GLN87P, GLU91P, GLY49r, GLY88P, LEU92P, LYS83P, LYS93P, PHE50r, PRO84P, SER48r, THR85P, VAL89P
• O-R: ALA68R, ALA70R, ALA91R, ALA94O, ARG26O, ARG69R, ARG92R, ASP103O, ASP89R, ASP90R, GLN73R, GLU95R, GLY154R, GLY156R, GLY23O, GLY51O, GLY54O, HIS158R, HIS25O, HIS49O, ILE102O, ILE22O, ILE93R, LEU105O, LYS113R, LYS24O, LYS47O, LYS55O, LYS70O, LYS77O, LYS92O, LYS96O, MET155R, MET58O, PHE53O, PHE68O, PHE94R, PRO100O, PRO157R, PRO50O, SER63R, SER65R, SER93O, SER95O, TRP69O, TYR48O, TYR52O, VAL101O, VAL56O, VAL64R
• O-r: ARG41r, PRO29O
• O-L: ARG117O, UNK152L
• R-U: GLU157U, GLY160R, HIS10R, ILE3R, LEU85U, LYS161R, SER7R, THR158U
• R-e: ARG100e, ARG107e, ARG110e, ARG160e, ARG88e, ASN93e, ASP4R, GLN104e, GLY2R, GLY91e, HIS5R, ILE111e, ILE156e, ILE3R, ILE92e, LEU103e, LEU108e, LYS101e, LYS206e, LYS8R, MET1R, PRO204e, PRO97e, SER113e, THR109e, THR6R, TRP203e
• R-D: ALA127D, ALA28D, ARG105R, ARG111R, ARG119D, ARG130R, ARG300D, ARG31D, ARG39R, ASN116D, ASN23R, ASN316D, ASP125R, ASP22R, ASP33D, ASP41R, GLU117D, HIS36D, ILE30D, ILE34D, LEU104R, LEU134D, LEU26R, LEU28R, LYS20R, LYS27R, LYS308D, LYS314D, LYS315D, PRO29D, PRO32D, SER124D, SER21R, SER27D, THR37D, TYR120D, TYR25R, VAL131D, VAL24R, VAL35D, VAL38D
• T-W: ARG64T, LYS74W
• T-X: ARG38T, ASN39T, LYS74X, SER37T
• T-p: ALA11T, ALA12T, ARG37p, ARG38T, ARG42T, ARG9T, CYS23p, GLY16T, LEU10T, LYS36p, LYS38p, LYS52T, SER13T, VAL14T, VAL15T, VAL17T
• U-e: ALA125U, ARG100e, GLN104e, GLN127U, GLN131U, GLN197e, HIS194e, LEU128U, LYS101e, LYS129U, LYS175e, LYS196e, LYS98e, PHE159U, PRO193e, PRO97e, THR158U, TYR156U, TYR176e, VAL126U
• U-y: ASN66U, LYS69U, THR68U, UNK1y, UNK2y, UNK3y, UNK4y, VAL67U
• U-Q: ALA11Q, ALA24U, ARG20U, ARG33Q, ARG35Q, ARG92U, ASP18U, ASP29Q, ASP72Q, GLN17Q, GLN32Q, GLN39Q, GLU94U, GLY23U, GLY71Q, HIS22U, HIS26U, HIS40Q, HIS98U, ILE48U, ILE69Q, LEU27U, LEU31U, LEU36Q, LYS21U, LYS32U, LYS34Q, LYS41Q, LYS43Q, LYS69U, PHE19U, PHE20Q, PRO19Q, SER10Q, SER13Q, SER14Q, SER28U, SER67Q, SER70U, THR18Q, THR28Q, THR29U, THR38Q, THR68Q, TYR30Q, TYR30U, TYR31Q, VAL25U, VAL33U, VAL37Q, VAL93U
• V-g: ASP47g, ASP53V, GLN55V, HIS54V, LEU52V, LYS41g
• V-j: ARG167V, ARG21j, LEU168V, THR169V, VAL166V
• V-o: ARG127V, ARG128V, ARG46o, THR129V, TYR130V
• V-D: ARG126V, ARG128V, ARG84D, GLY81D, GLY83D, THR82D
• X-c: ALA136X, ALA29c, ALA50X, ARG115X, ARG138X, ARG48c, ARG56X, ARG81c, ASN117X, ASN137X, ASN55X, ASN59c, ASP58X, ASP79c, GLN34c, GLN62c, GLN65X, GLN76c, GLN85X, GLU30c, GLU64X, GLY140X, HIS53X, ILE139X, ILE142X, ILE44c, ILE51c, ILE58c, ILE63X, ILE67X, LEU102X, LEU21c, LEU24c, LEU28c, LEU31c, LEU36c, LEU55c, LEU57X, LEU80c, LYS25c, LYS26c, LYS32c, LYS35c, LYS49X, LYS61X, LYS73c, LYS74c, LYS78c, PRO52X, PRO66X, PRO77c, SER59X, SER69X, THR68X, TYR103X, TYR141X, TYR54X, TYR70c, TYR75c, VAL22c, VAL33c, VAL47c, VAL51X, VAL54c, VAL66c
• X-o: ALA14o, ALA16o, ARG115X, ARG21o, ASN117X, GLN11o, GLN19o, GLY118X, LYS10o, LYS120X, LYS15o, LYS17o, LYS18o, LYS5o, MET13o, MET88X, PHE7o, PRO116X, THR119X, VAL114X
• Y-l: ALA83l, LYS113Y, LYS85l
• Y-o: ARG30o, ASN32o, ASN33o, ASN98Y, LEU76Y, PHE20Y, TYR74Y
• Y-D: ARG12Y, ARG13Y, ARG195D, ARG197D, ARG198D, ASP11Y, LYS193D
• a-f: ARG35f, ARG52f, ARG65a, ASN76a, ASN78a, GLU55f, GLU57f, HIS79a, ILE68a, ILE72a, LEU51f, LEU56f, LEU62f, LEU80a, LEU81a, LYS28f, LYS53f, LYS67a, LYS69a, LYS73a, MET61f, PHE71a, PRO49f, PRO70a, PRO82a, SER54f, THR83a, TYR27f, TYR58f, TYR59f, TYR77a, TYR85a, VAL31f, VAL50f, VAL74a, VAL75a
• a-i: ALA32i, ALA39i, ALA44a, ALA50i, ARG10i, ARG31i, ARG41i, ARG48a, ARG84a, ASN18i, ASN76a, ASN78a, ASP46i, ASP88a, CYS44i, CYS47i, GLN33i, GLN3i, GLN52i, GLU47a, GLY45a, GLY45i, GLY48i, HIS34i, HIS69i, ILE20i, ILE46a, ILE68a, ILE72a, LEU38i, LEU51a, LEU51i, LEU80a, LEU81a, LYS19i, LYS36i, LYS37i, LYS43i, LYS52a, LYS67a, LYS67i, LYS69a, LYS73a, PHE71a, PHE7i, PRO42i, PRO50a, PRO70a, PRO82a, SER49i, SER66i, THR40i, THR64i, THR66a, THR68i, TYR13i, TYR49a, TYR77a, TYR85a, VAL24a, VAL35i, VAL65i, VAL74a, VAL75a
• a-m: ALA19a, ARG15a, ARG17a, ARG65a, CYS59m, CYS60m, GLY16a, ILE68a, LYS61m, PHE41m, TYR18a
• a-p: ARG30p, PHE38a
• a-x: ARG84a, ASN76a, GLU90a, HIS79a, ILE72a, LEU80a, LEU87a, PRO82a, THR83a, THR86a, UNK14x, UNK18x, UNK1x, UNK2x, UNK3x, UNK4x, UNK5x, UNK6x, UNK7x, UNK8x, VAL75a
• d-z: ASN42d, HIS43d, UNK14z
• c-l: ALA82c, ALA83l, ARG10c, ARG67c, ARG72l, ARG73l, ARG81c, ARG86c, ARG89c, ASN76l, ASP79c, GLN76c, GLN79l, GLU60c, GLY77l, HIS69l, LEU80c, LEU88c, LYS68l, LYS75l, LYS83c, LYS84c, PHE74l, PHE78l, SER71l, SER82l, THR85c, VAL70l
• c-o: ARG38c, TRP26o
• f-i: ALA32i, ALA60f, ALA63i, ARG31i, ARG35f, ARG52f, ARG58i, ASN18i, GLN33i, GLN36f, GLU55f, GLU57f, GLY27i, GLY28i, GLY37f, HIS34i, HIS69i, ILE20i, ILE29i, LEU30i, LEU34f, LEU51i, LEU62f, LYS21i, LYS32f, LYS64f, LYS67i, MET61f, SER63f, SER66i, THR64i, THR65f, THR68i, TYR58f, TYR59f, VAL22i, VAL23i, VAL31f, VAL35i, VAL65i
• f-m: ALA46f, ARG36m, ARG52f, ARG86f, ASN47f, ASN74f, ASN75f, ASP38m, CYS39m, CYS42m, CYS59m, CYS60m, GLN71f, GLY43m, GLY72f, GLY73f, GLY88f, LEU51f, LEU84f, LYS44m, LYS45m, LYS62m, PHE41m, PHE85f, PRO49f, SER40m, THR46m, THR48f, VAL50f, VAL87f
• f-x: GLU57f, LEU51f, LYS53f, PRO49f, SER54f, UNK1x, UNK2x, UNK3x, UNK4x, VAL50f
• e-D: ARG145e, ARG326D, ARG41e, ARG60e, ASN328D, ASP165e, ASP182e, ASP362D, GLU337D, GLU345D, GLU56e, GLU59e, GLY348D, LYS338D, LYS342D, LYS34e, LYS360D, LYS38e
• e-S: ALA65e, ALA69e, ARG28S, ARG67e, ASP68e, GLU233e, GLU234e, GLU36S, LYS127S, LYS30S, LYS66e, LYS69S, LYS70e
• h-j: ALA91j, ARG47h, ARG60j, GLU58j, GLY61j, HIS13h, LYS12h, LYS92j, SER62j, VAL59j
• i-x: ASN14i, LYS106i, LYS36i, LYS37i, UNK14x, UNK17x, UNK18x, UNK19x, UNK20x, VAL104i, VAL105i
• l-o: ARG11l, ARG24l, ARG25l, ARG8o, ASN13l, ASN20l, ASN50o, CYS19l, GLN4o, GLY23l, HIS16l, ILE51o, ILE9o, LEU18l, LYS12o, LYS14l, LYS48o, MET13o, MET49o, PHE8l, SER26l, THR17l, TYR39l, VAL29l
• l-D: ALA51l, ALA53l, ALA56D, ARG55l, ARG56l, GLN59D, GLY50l, LYS52l, LYS55D, SER53D, SER61D, THR60D, TRP49l
• t-u: ASN53t, ASN60t, GLU18u, GLY51t, LYS55u, PHE61t, SER62t, VAL59u
• t-v: ALA10t, ALA11t, ALA12v, ALA13v, ALA15t, ALA24v, ALA32t, ALA33t, ALA5v, ALA6t, ALA6v, ASN11v, ASN15v, ASN31t, ASN34t, ASP16t, GLU18t, GLU24t, GLU27v, GLY14v, GLY30v, ILE13t, ILE19t, ILE22v, ILE25v, ILE31v, ILE54v, LEU10v, LEU12t, LEU14t, LEU26t, LEU26v, LEU27t, LEU29t, LEU4v, LEU58t, LEU7t, LEU8v, LEU9v, LYS21v, LYS23v, LYS25t, LYS2v, MET1v, PRO17v, PRO36t, SER17t, SER28v, SER5t, SER8t, THR16v, THR20v, THR28t, THR30t, TYR3v, TYR7v, TYR9t, VAL29v, VAL35t, VAL50v
• t-w: ALA42t, ALA44w, ALA46t, ALA48t, ASN39t, ASN58w, ASP35w, ASP43t, ASP50t, GLN52t, GLU32w, GLU34w, GLU36w, GLU38t, GLY51t, ILE33w, ILE40t, ILE44t, LEU42w, LEU49t, LEU57t, LYS37w, LYS47t, MET1w, PHE45t, PHE61t, SER39w, SER40w, SER43w, SER62t, TRP41t, TYR3w, VAL38w, VAL41w
• u-w: ALA10u, ALA11u, ALA12w, ALA13w, ALA15u, ALA24w, ALA32u, ALA33u, ALA5w, ALA6u, ALA6w, ASN11w, ASN15w, ASN31u, ASN34u, ASN58w, ASP16u, GLU18u, GLU20u, GLU24u, GLU27w, GLU32w, GLY14w, GLY30w, ILE13u, ILE19u, ILE22w, ILE25w, ILE31w, ILE54w, LEU10w, LEU12u, LEU14u, LEU26u, LEU26w, LEU27u, LEU29u, LEU4w, LEU58u, LEU7u, LEU8w, LEU9w, LYS21w, LYS23w, LYS25u, LYS2w, MET1w, PHE45u, PHE61u, PRO17w, PRO36u, SER17u, SER28w, SER5u, SER62u, SER8u, THR16w, THR20w, THR28u, THR30u, TYR3w, TYR7w, TYR9u, VAL29w, VAL35u, VAL50w