3IZR

localization of the large subunit ribosomal proteins into a 5.5 a cryo-em map of triticum aestivum translating 80s ribosome

• Total interactions analyzed: 1326
• Total true interactions: 87
• Strongest Interaction:
  • Chains: H-X
  • Int. Res.: 24
  • Norm. En. per Res.: -4.3318
• Hub Node: B(11)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-L	0.0	0.0	0.2176	0.2176	24	21	0	2160	0	0	0
A-k	0.0	-1.2209	-7.1445	-8.3654	21	0	0	538	0	7	10
B-H	0.0	0.0	-23.0518	-23.0518	17	3	0	1049	0	4	15
B-P	0.0	0.0	-7.7031	-7.7031	12	0	0	415	0	0	5
B-X	0.0	7.0264	-17.0812	-10.0548	10	0	0	820	0	0	6
B-f	0.0	0.0	-0.3525	-0.3525	7	0	0	65	0	0	0
B-a	0.0	0.0	-0.6144	-0.6144	16	0	0	167	0	3	3
B-x	-11.2969	0.0	-122.353	-133.6499	41	16	0	5316	0	0	0
B-m	-75.7259	-28.0378			21
E-Q	-16.7851	55.2225	-91.8217	-53.3842	38	7	0	3567	0	4	32
E-r	0.0	0.0	-8.6718	-8.6718	11	0	0	432	0	0	0
F-z	0.0	0.0	-6.0229	-6.0229	28	3	0	1186	0	0	0
F-N	-11.8649	2.8838	-71.9508	-80.9319	26	12	0	2722	0	3	5
F-S	-8.2373	-39.4592	-70.8898	-118.5863	37	5	1	2697	3	17	5
F-K	0.0	6.8493			2
H-P	-21.3541	-25.0191	-201.802	-248.1752	86	11	7	9359	3	25	23
H-X	-29.8858	0.5346	-74.6115	-103.9627	24	18	1	3530	0	0	18
H-q	-12.4113	0.0	-14.0269	-26.4382	25	1	0	880	0	0	17
H-k	-5.3737	-1.6685	-61.6894	-68.7316	48	5	1	3114	0	13	16
H-x	0.0	0.0	-10.6621	-10.6621	13	0	0	872	0	0	0
M-Z	-26.8603	7.4754	-113.928	-133.3129	54	21	5	5879	0	11	19
M-C	-22.8893	5.6151	-76.096	-93.3702	51	26	1	3986	0	22	30
P-O	0.0	0.0	-0.0102	-0.0102	4	0	0	8	0	0	1
P-l	0.0	0.0	-0.051	-0.051	2	0	0	20	0	0	2
P-r	-2.4519	0.0	-21.7264	-24.1783	17	1	0	931	0	1	4
P-L	0.0	0.0	-9.7839	-9.7839	11	0	0	731	0	0	0
P-k	-40.1982	-22.3541	-81.0727	-143.625	49	25	1	4827	1	20	20
P-c	0.0	1.0391	-47.7328	-46.6937	37	2	0	2850	0	15	27
O-R	-11.8307	-6.9269	-36.9497	-55.7073	42	5	0	2264	0	7	19
O-r	0.0	0.0	-0.0246	-0.0246	4	0	0	20	0	0	1
O-L	0.0	0.0	-67.8268	-67.8268	124	102	0	11774	0	0	0
R-U	0.0	0.0	-0.0013	-0.0013	5	0	0	4	0	2	1
R-L	0.0	0.0	-1.3755	-1.3755	5	0	0	199	0	0	0
R-e	-10.7236	-23.7545	-51.0977	-85.5758	26	3	0	2019	1	6	1
R-D	-23.216	-13.8261			21
Q-U	0.0	1.5889	-103.82	-102.2311	52	5	5	4469	0	8	18
Q-I	-20.2165	-12.3102			12
T-X	0.0	0.0	-0.0025	-0.0025	2	0	0	3	0	2	1
T-W	0.0	0.0	-0.0009	-0.0009	3	0	0	3	0	0	0
T-p	-4.8758	3.6902	-19.2918	-20.4775	14	3	0	790	0	0	8
U-y	-7.562	0.0	-17.7754	-25.3374	18	1	0	982	0	0	0
U-e	0.0	0.0	-8.2483	-8.2483	22	1	0	538	0	5	8
X-o	-2.2893	0.4279	-35.6387	-37.5002	22	0	1	1897	0	6	18
X-c	0.0	3.0605	-65.0657	-62.0052	62	4	2	4038	0	6	16
Z-C	0.0	6.5104	-4.518	1.9924	16	2	0	419	0	2	2
Y-o	0.0	-6.6095	-3.6148	-10.2243	8	0	0	313	0	4	3
Y-D	-2.7156	5.8022			3
b-h	-5.2553	-4.078	-51.2331	-60.5664	38	19	0	2919	0	12	9
b-G	0.0	-2.3146	-15.2188	-17.5334	23	1	1	1262	0	8	9
b-e	0.0	0.0	-0.0427	-0.0427	7	0	0	18	0	1	1
b-D	-2.3764	0.0			2
d-z	0.0	0.0	-0.0467	-0.0467	2	0	0	12	0	0	0
f-a	0.0	-7.2722	-60.59	-67.8622	33	5	4	2915	0	6	7
f-i	-7.9085	11.5366	-99.6446	-96.0166	43	9	1	4198	1	4	17
f-x	0.0	0.0	-6.8534	-6.8534	10	2	0	394	0	0	0
f-m	-2.8952	0.7997			5
h-G	0.0	0.0	-0.0079	-0.0079	3	0	0	7	0	1	1
h-j	0.0	0.0	-2.1143	-2.1143	13	0	0	239	0	0	0
l-o	-9.4047	0.0	-43.379	-52.7837	25	1	2	1839	0	0	17
l-c	0.0	1.8457	-24.0454	-22.1997	28	0	0	1400	0	2	14
l-D	-6.2982	0.89			3
o-p	0.0	0.0	-0.433	-0.433	5	0	0	61	0	0	0
G-N	-6.3416	-2.4719	-145.215	-154.0285	41	25	2	5994	1	21	27
G-j	0.0	0.0	-86.8977	-86.8977	37	11	0	3392	0	6	11
G-e	0.0	0.0	-0.0161	-0.0161	4	0	0	13	0	0	1
L-c	0.0	0.0	-45.8998	-45.8998	31	3	0	2462	0	0	0
N-S	-34.7621	-29.327	-309.187	-373.2762	108	107	5	16515	2	39	52
N-j	-13.3495	-7.0568	-59.1793	-79.5856	44	2	0	2562	0	9	13
N-K	-27.4073	-8.2337			14
S-j	0.0	0.0	-0.0115	-0.0115	2	0	0	9	0	0	0
S-e	-45.7271	44.6936	-283.795	-284.8286	112	85	6	13480	0	29	42
a-i	0.0	10.8814	-201.158	-190.2766	74	19	4	7996	0	2	24
a-p	0.0	0.0	-0.9449	-0.9449	5	0	0	153	0	0	1
a-x	0.0	0.0	-8.9961	-8.9961	15	1	0	457	0	0	0
i-x	-2.6068	0.0	-6.1634	-8.7701	9	0	0	445	0	0	0
j-K	-10.4355	27.2865			4
J-s	0.0	9.1046	-7.3352	1.7694	14	0	0	533	0	5	4
t-u	0.0	0.0	-0.7061	-0.7061	9	0	0	110	0	7	5
t-v	-16.6521	-16.9726	652.957	619.3324	57	111	21	8353	1	8	7
t-w	-17.0407	-16.4382	-106.647	-140.1259	41	24	1	4208	2	10	12
t-s	0.0	0.0	-174.359	-174.359	60	40	15	8351	0	1	0
u-w	-3.7496	-20.7001	1107.56	1083.1103	59	138	21	9228	1	8	8
u-s	-11.3714	-23.5591	-148.23	-183.1606	49	31	13	7147	2	9	5
v-s	-15.8633	-45.0321	-91.5035	-152.3989	77	70	9	9334	6	26	25
w-s	-4.2961	13.7449	-160.6	-151.1512	56	36	6	7683	0	1	3
e-D	-50.6792	-38.5689			23
C-K	-7.3772	-68.8738			7

Interface residues

• A-L: ASN187A, ASN199A, ILE182A, LEU189A, LEU192A, LEU193A, LYS194A, LYS195A, LYS53A, PHE188A, PRO55A, SER185A, SER191A, UNK186L, UNK187L, UNK188L, UNK189L, UNK190L, UNK191L, UNK192L, UNK193L, UNK194L, VAL186A, VAL190A
• A-k: ALA8A, ARG201A, ARG214A, ARG39k, ARG78k, ASP7A, CYS202A, GLN198A, GLU49k, HIS41k, ILE60k, LEU46k, LYS10A, LYS79k, PHE42k, PHE53k, THR82k, TRP197A, TYR40A, VAL40k, VAL9A
• B-H: ARG30B, ARG58H, ARG60H, ARG61H, ARG68B, ASP33B, GLN59H, HIS65B, HIS71B, ILE62H, LYS68H, LYS70B, PHE67B, PRO66B, TYR40B, TYR69B, VAL69H
• B-P: ALA7B, ARG9B, GLN8B, GLY232B, GLY78P, ILE5B, LYS77P, MET1B, PRO230B, PRO231B, TYR81P, VAL4B
• B-X: ARG44X, ARG68B, HIS43X, LEU48X, LYS46X, LYS70B, PHE67B, PRO45X, THR47X, TYR69B
• B-f: ASN51f, GLN86B, GLY85B, PHE87B, PRO53f, PRO54f, VAL44B
• B-a: ARG64B, ASN76a, ASP47B, HIS79a, LEU72a, LEU80a, LYS42B, LYS60B, LYS64a, LYS69a, LYS73a, PHE18a, PHE87B, THR46B, THR84B, VAL44B
• B-x: ALA94B, ARG37B, ARG92B, ARG93B, ASN100B, ASN38B, ASP33B, GLN86B, GLU36B, GLY35B, GLY39B, GLY85B, HIS65B, LEU32B, LEU41B, LEU96B, LYS42B, PHE34B, PHE67B, PHE87B, PRO66B, SER97B, THR95B, TYR40B, TYR89B, UNK10x, UNK11x, UNK12x, UNK13x, UNK14x, UNK16x, UNK1x, UNK2x, UNK3x, UNK4x, UNK5x, UNK6x, UNK7x, UNK8x, UNK9x, VAL88B
• B-m: ALA65m, ARG80m, ASP47B, GLN168B, GLN86B, GLU30m, GLU80B, GLY171B, GLY66m, HIS50B, ILE48B, LYS13m, LYS177B, LYS181B, LYS50m, LYS62m, LYS64m, MET82B, SER75m, THR84B, VAL63m
• E-Q: ALA148E, ARG139E, ARG142E, ARG143E, ARG144E, ARG145E, ARG149E, ARG152Q, ARG19Q, ARG26Q, ARG27Q, ARG28Q, ARG54Q, ASN58Q, CYS146E, GLN29Q, GLY30Q, GLY5Q, GLY6Q, ILE151Q, ILE152E, LEU150Q, LEU285Q, LEU3Q, LYS147E, LYS25Q, LYS31Q, LYS52Q, LYS9Q, MET1E, PHE20Q, PHE55Q, THR32Q, THR57Q, TYR16Q, TYR53Q, VAL140E, VAL56Q
• E-r: ARG62E, ASN64E, GLU65E, LEU104r, LEU32E, LYS51E, LYS66E, PHE105r, PHE49E, SER103r, THR102r
• F-z: ALA96F, ARG172F, ARG92F, ASN161F, GLU142F, HIS165F, ILE171F, LEU175F, LYS90F, PHE174F, SER181F, TYR179F, UNK10z, UNK11z, UNK12z, UNK13z, UNK14z, UNK1z, UNK2z, UNK3z, UNK4z, UNK5z, UNK6z, UNK7z, UNK8z, UNK9z, VAL180F, VAL94F
• F-N: ALA58F, ARG35N, ARG5N, ASN34N, ASN42F, ASP32N, GLN33N, GLY61F, HIS40F, ILE4F, LEU41F, LEU43F, LEU5F, LYS2F, LYS4N, LYS51N, MET1F, MET1N, PHE3N, PHE60F, PHE6N, PRO2N, THR3F, THR62F, TRP59F, VAL7N
• F-S: ALA58F, ALA6F, ARG115S, ARG156S, ARG159S, ARG163S, ARG63F, ASN140S, ASN42F, ASP148S, ASP44F, ASP57F, GLN46F, GLN55F, GLU8F, ILE4F, LEU43F, LEU48F, LEU5F, LYS157S, LYS164S, LYS166S, LYS2F, MET1F, MET66F, PHE144S, PHE60F, PRO160S, PRO161S, SER7F, THR141S, THR162S, THR3F, THR62F, TRP59F, VAL158S, VAL56F
• F-K: ARG64F, HIS138K
• H-P: ALA164H, ALA3P, ALA85H, ARG20P, ARG226H, ARG24P, ARG26P, ARG41P, ARG44P, ARG49P, ARG63P, ARG78H, ASN133H, ASN74H, ASN83H, ASN87H, ASP154H, ASP17P, ASP46P, ASP81H, CYS27P, GLN15P, GLN23P, GLN32P, GLN33P, GLN75H, GLU140H, GLU157H, GLU224H, GLU29P, GLU9P, GLY131H, GLY2P, HIS134H, ILE156H, LEU10P, LEU132H, LEU158H, LEU162H, LEU165H, LEU194H, LEU39P, LEU73H, LEU80H, LEU84H, LEU88H, LEU92H, LYS179H, LYS5P, LYS82H, LYS90H, MET19P, MET1P, MET234H, MET91H, PHE21P, PHE76H, PHE89H, PRO155H, PRO34P, PRO42P, PRO45P, SER16P, SER8P, THR136H, THR190H, THR43P, THR77H, THR79H, THR86H, TRP11P, TRP161H, TRP28P, TYR137H, TYR30P, TYR4P, TYR6P, VAL135H, VAL153H, VAL159H, VAL160H, VAL18P, VAL22P, VAL25P, VAL37P, VAL7P
• H-X: ALA72H, ARG44X, ARG61H, ARG66H, GLN65H, HIS43X, ILE62H, LEU63H, LEU67H, LEU73H, LYS46X, LYS49X, LYS64H, LYS68H, PHE42X, PRO45X, PRO70H, PRO71H, SER39X, THR38X, THR41X, THR47X, VAL40X, VAL69H
• H-q: ALA115H, ARG11q, ARG15q, ARG21q, ARG23q, ARG2q, GLN112H, GLN22q, GLU116H, GLY117H, HIS187H, ILE126H, LYS118H, LYS124H, LYS188H, LYS189H, LYS19q, LYS25q, LYS7q, MET1q, PRO125H, SER24q, THR119H, TYR130H, VAL120H
• H-k: ALA103k, ALA107k, ALA164H, ARG101k, ARG167H, ARG44k, ARG48k, ARG98k, ASN87H, ASP109k, ASP223H, CYS166H, GLN141H, GLU140H, GLU157H, GLU170H, GLU224H, GLY104k, GLY105k, GLY106k, GLY108k, ILE156H, LEU162H, LEU165H, LEU88H, LEU92H, LEU97k, LYS111k, LYS112k, LYS168H, LYS221H, LYS90H, LYS99k, MET100k, MET169H, MET91H, MET93k, PHE222H, PHE89H, PRO163H, SER102k, SER94k, SER95k, TRP161H, TYR137H, VAL160H, VAL225H, VAL96k
• H-x: ARG58H, ARG60H, ARG61H, GLN59H, UNK10x, UNK11x, UNK12x, UNK13x, UNK14x, UNK15x, UNK16x, UNK17x, UNK18x
• M-Z: ALA138M, ALA26Z, ARG22Z, ARG25Z, ARG40Z, ARG83M, ARG85M, ARG89M, ARG90M, ASN137M, ASN27M, ASP100M, ASP27Z, ASP92M, CYS38Z, GLN29Z, GLN84M, GLU6Z, GLU99M, GLY119M, GLY122M, GLY18Z, GLY20Z, GLY93M, HIS43Z, ILE117M, ILE121M, ILE139M, ILE15Z, ILE21Z, ILE24Z, LEU32Z, LYS123M, LYS19Z, LYS39Z, LYS86M, MET96M, PHE23Z, PHE31Z, PHE33Z, PHE42Z, PHE95M, PHE98M, PRO120M, PRO17Z, PRO87M, SER28Z, THR118M, TRP88M, TYR16Z, TYR97M, VAL140M, VAL30Z, VAL94M
• M-C: ALA75C, ARG10C, ARG240C, ARG48M, ARG4C, ARG51M, ARG58C, ARG89M, ARG90M, ASN12M, ASN50M, ASP127M, ASP92M, CYS73C, GLU124M, GLU59C, GLU61C, GLU71C, GLU74C, GLU7C, GLY11M, GLY12C, GLY237C, GLY47M, GLY93M, HIS11C, HIS55C, HIS68C, HIS8C, LEU128M, LEU49M, LEU67C, LYS123M, LYS13M, LYS5C, LYS62C, LYS66C, LYS69C, LYS70C, LYS91M, PHE14M, PHE6C, PRO242C, PRO9C, SER65C, THR239C, THR72C, VAL238C, VAL57C, VAL60C, VAL94M
• P-O: ALA35O, GLY36O, GLY37O, HIS179P
• P-l: ARG108P, ARG43l
• P-r: ARG45r, ARG73P, GLN47r, GLN87P, GLN91P, GLY49r, GLY88P, HIS86P, ILE89P, LEU92P, LYS46r, LYS83P, LYS85P, PRO84P, SER48-2.4519182.892906, SER48r, TYR50r
• P-L: ARG189P, ARG194P, LYS193P, THR191P, TRP192P, UNK19L, UNK22L, UNK23L, UNK24L, UNK25L, UNK26L
• P-k: ALA103k, ALA107k, ARG101k, ARG12P, ARG13P, ARG20P, ARG24P, ARG50P, ARG71k, ARG90k, ARG98k, ASP109k, ASP17P, GLN15P, GLU62k, GLU91k, GLU92k, GLU9P, GLY104k, GLY105k, GLY106k, GLY108k, GLY2P, LEU10P, LEU97k, LYS110k, LYS111k, LYS14P, LYS58k, LYS5P, LYS68k, LYS89k, LYS99k, MET100k, MET19P, MET1P, MET93k, PHE21P, SER102k, SER16P, SER8P, SER94k, SER95k, TRP11P, TYR6P, VAL18P, VAL22P, VAL7P, VAL96k
• P-c: ALA138P, ALA91c, ARG103c, ARG114P, ARG143P, ARG147P, ARG94c, ARG95c, ASN144P, ASN149P, ASP145P, ASP99c, CYS152P, GLU100c, GLU106c, HIS139P, HIS156P, ILE92c, LEU105c, LEU151P, LEU96c, LYS101c, LYS107c, LYS109c, LYS153P, LYS157P, PRO146P, PRO154P, PRO98c, SER102c, SER140P, SER97c, THR108c, TRP150P, VAL104c, VAL137P, VAL155P
• O-R: ALA155R, ALA93O, ARG112R, ARG26O, ARG65R, ARG91R, ASN115R, ASP88R, ASP89R, ASP97O, GLN93R, GLU94R, GLY153R, GLY23O, GLY51O, GLY54O, HIS162R, HIS25O, HIS49O, HIS69O, ILE22O, ILE92R, ILE96O, LYS154R, LYS24O, LYS47O, LYS55O, MET64R, MET90R, PHE53O, PHE68O, PRO50O, PRO94O, SER63R, THR108R, THR163R, THR99O, TYR48O, TYR52O, VAL56O, VAL95O, VAL98O
• O-r: ALA37r, ARG32O, ARG41r, PRO29O
• O-L: ALA122O, ALA129O, ALA135O, ALA136O, ALA139O, ALA144O, ALA72O, ARG12O, ARG59O, ARG63O, ARG77O, ARG9O, ASN66O, ASN74O, CYS70O, GLN100O, GLU115O, GLU76O, GLY108O, GLY110O, GLY137O, GLY13O, GLY23O, GLY57O, HIS25O, HIS62O, ILE118O, ILE22O, LEU107O, LEU112O, LEU141O, LEU142O, LEU64O, LEU78O, LYS105O, LYS109O, LYS11O, LYS121O, LYS123O, LYS127O, LYS132O, LYS134O, LYS24O, MET111O, MET58O, MET81O, PHE61O, PRO117O, PRO71O, SER126O, SER65O, THR104O, THR143O, THR99O, TRP79O, TYR60O, UNK116L, UNK117L, UNK118L, UNK119L, UNK137L, UNK13L, UNK140L, UNK141L, UNK142L, UNK143L, UNK144L, UNK145L, UNK146L, UNK147L, UNK148L, UNK149L, UNK14L, UNK150L, UNK151L, UNK152L, UNK153L, UNK154L, UNK155L, UNK156L, UNK157L, UNK158L, UNK159L, UNK15L, UNK160L, UNK161L, UNK162L, UNK163L, UNK164L, UNK165L, UNK166L, UNK167L, UNK168L, UNK169L, UNK16L, UNK170L, UNK171L, UNK172L, UNK173L, UNK174L, UNK175L, UNK176L, UNK178L, UNK17L, UNK18L, UNK19L, UNK20L, UNK79L, UNK80L, UNK81L, UNK82L, UNK83L, UNK84L, UNK85L, UNK86L, VAL106O, VAL119O, VAL120O, VAL128O, VAL140O, VAL73O, VAL75O, VAL82O, VAL98O
• R-U: ALA7R, HIS160R, ILE3R, ILE85U, VAL156U
• R-L: ALA155R, GLY153R, LYS154R, UNK13L, UNK14L
• R-e: ALA7R, ARG109e, ARG111e, ARG39R, ARG90e, ASN115e, ASN95e, ASP4R, GLN106e, GLN112e, GLY2R, GLY8R, GLY93e, GLY9R, ILE113e, ILE3R, ILE94e, LEU110e, LEU5R, LYS102e, LYS208e, MET1R, PRO206e, PRO99e, VAL10e, VAL6R
• R-D: ARG129R, ARG317D, ARG37D, ARG38R, ARG39R, ARG42D, ASN326D, ASP124R, ASP22R, ASP23R, ASP39D, GLU134R, GLU313D, GLU318D, LYS20R, LYS319D, LYS321D, LYS325D, LYS41R, TYR25R, VAL303D
• Q-U: ALA36Q, ALA47U, ALA68Q, ARG20U, ARG32U, ARG35Q, ARG37Q, ARG39Q, ARG70U, ARG92U, ASN42Q, ASP33Q, ASP44Q, ASP73Q, GLN21Q, GLN43Q, GLU94U, GLY23U, GLY72Q, HIS14Q, HIS49U, ILE25U, ILE38Q, ILE70Q, LEU27U, LEU31U, LEU40Q, LYS18Q, LYS21U, LYS22U, LYS23Q, LYS45Q, LYS47Q, LYS69U, PHE17Q, PHE19U, PHE24Q, PRO18U, PRO26U, THR28U, THR29U, THR32Q, THR33U, THR41Q, THR69Q, TYR24U, TYR30U, TYR34Q, TYR67Q, VAL22Q, VAL48U, VAL93U
• Q-I: ASP297Q, ASP298Q, ASP302Q, ASP44I, GLU179I, GLU180I, GLU300Q, GLU301Q, GLU304Q, LEU184I, LYS183I, SER291Q
• T-X: LYS84X, SER37T
• T-W: ARG64T, ARG65T, ARG83W
• T-p: ARG35p, ARG52T, CYS17T, CYS23p, CYS39p, GLY18T, LEU15T, LYS16T, LYS21T, LYS36p, LYS37p, LYS38p, SER12T, VAL14T
• U-y: ALA71U, ARG88U, ASN66U, GLY73U, HIS90U, ILE72U, LYS69U, THR68U, TRP65U, UNK1y, UNK2y, UNK3y, UNK4y, UNK5y, UNK7y, UNK8y, VAL36U, VAL67U
• U-e: ASP155U, GLN106e, GLN131U, GLU199e, HIS178e, HIS196e, HIS98e, ILE126U, LEU160U, LYS100e, LYS102e, LYS103e, LYS129U, PRO195e, PRO99e, SER127U, THR128U, TYR154U, VAL125U, VAL156U, VAL157U, VAL80U
• X-o: ALA100X, ALA14o, ARG125X, ARG18o, ARG8o, ASP127X, GLN11o, GLN17o, GLY128X, ILE124X, LEU13o, LEU98X, LYS10o, LYS129X, LYS12o, LYS130X, LYS15o, LYS5o, LYS99X, PHE7o, PRO126X, THR6o
• X-c: ALA146X, ALA39c, ALA61X, ALA80c, ARG34c, ARG58X, ARG64X, ARG67c, ARG85c, ASN147X, ASN63c, ASN65X, ASP68X, ASP83c, GLN32c, GLN36c, GLN66c, GLN69X, GLN71X, GLY150X, GLY31c, GLY63X, ILE149X, ILE151X, ILE152X, ILE35c, ILE48c, ILE55c, ILE62c, ILE95X, LEU23c, LEU30c, LEU33c, LEU59c, LEU67X, LEU70c, LEU73X, LEU77X, LEU82c, LEU84c, LYS129X, LYS148X, LYS27c, LYS37c, LYS66X, LYS74X, LYS78c, MET112X, PRO62X, PRO76X, PRO81c, SER60X, THR20c, THR28c, THR78X, TYR113X, TYR70X, TYR74c, TYR75X, TYR79c, VAL38c, VAL59X
• Z-C: ARG373C, ASP364C, CYS73C, GLU71C, GLU74C, GLY18Z, HIS55C, ILE56C, LEU3Z, LYS14Z, LYS19Z, LYS368C, LYS4Z, PRO17Z, THR72C, VAL57C
• Y-o: ARG30o, ARG75Y, ARG76Y, ASP32o, MET29o, THR20Y, THR31o, TYR73Y
• Y-D: ARG11Y, ARG204D, LYS199D
• b-h: ALA113h, ALA114h, ALA120b, ALA122b, ALA68b, ARG112h, ARG113b, ARG123b, ARG129b, ARG91h, ASN90h, ASP117h, ASP67b, GLN115h, GLU111h, GLU84h, GLY64b, HIS89h, ILE118h, LEU116b, LEU116h, LEU121b, LEU124b, LEU85h, LEU86h, LYS118b, LYS66b, MET87h, MET88h, PRO119b, SER125b, SER126b, SER130b, THR117b, THR75b, TYR128b, VAL127b, VAL65b
• b-G: ALA102b, ALA120b, ALA122b, ALA43G, ALA44G, ALA46G, ARG113b, ARG123b, ASP115b, GLU40G, GLU47G, GLU95b, ILE45G, LEU116b, LYS118b, LYS41G, LYS94b, LYS98b, PRO119b, PRO42G, THR117b, TYR111b, TYR112b
• b-e: ASN110b, ASP109b, GLN106b, GLU4e, LYS7e, MET1e, SER108b
• b-D: LYS85b, THR150D
• d-z: PHE39d, UNK14z
• f-a: ARG39f, ARG56f, ARG67a, ASN76a, CYS70a, GLU59f, GLU61f, HIS79a, ILE60f, LEU35f, LEU55f, LEU66f, LEU72a, LEU74a, LYS32f, LYS57f, LYS65a, LYS69a, LYS73a, MET65f, MET81a, PHE71a, PHE77a, PRO53f, PRO54f, PRO82a, SER58f, THR62f, THR78a, TYR31f, TYR63f, VAL68a, VAL75a
• f-i: ALA67f, ARG21i, ARG39f, ARG56f, ARG64i, ARG66i, ARG69i, ARG71i, ASN70i, GLN33i, GLU59f, GLY28i, ILE51i, ILE60f, LEU30i, LEU35f, LEU38f, LEU42f, LEU55f, LEU66f, LEU67i, LYS29i, LYS32f, LYS36f, LYS68f, MET65f, PRO65i, SER40f, SER41f, SER58f, SER68i, THR20i, THR33f, THR37f, THR62f, TYR31f, TYR32i, TYR34i, TYR63f, VAL22i, VAL23i, VAL31i, VAL34f
• f-x: ARG56f, ASN51f, CYS52f, LEU55f, LYS57f, PRO53f, PRO54f, SER58f, UNK1x, UNK2x
• f-m: ARG90f, ASN50f, ASP59m, CYS42m, LYS44m
• h-G: ARG91h, ILE45G, MET88h
• h-j: ARG14h, ASN64j, ASP65j, LEU52h, LYS100j, LYS12h, LYS48h, LYS62j, PRO95j, SER63j, SER66j, THR96j, VAL11h
• l-o: ARG11l, ARG24l, ARG25l, ARG8o, CYS19l, GLY23l, GLY50o, HIS16l, HIS4o, ILE9o, LEU13o, LEU18l, LEU29l, LEU49o, LYS12o, LYS14l, LYS16o, LYS48o, PHE27l, PHE51o, SER26l, THR15l, THR17l, TYR39l, VAL20l
• l-c: ALA86c, ALA91c, ARG68l, ARG71c, ARG72l, ARG73l, ARG85c, ARG90c, ARG93c, ASN13c, ASN77l, ASP83c, GLN88c, GLY9c, HIS69l, ILE92c, LEU84c, LEU96c, LYS75l, LYS7c, LYS87c, PHE74l, PHE78l, PRO71l, SER76l, THR85l, THR89c, VAL70l
• l-D: ARG61D, LYS52l, SER67D
• o-p: ARG26p, ASP16p, LYS17p, LYS48p, MET1o
• G-N: ALA113N, ALA127G, ALA169G, ALA186G, ALA191G, ARG107N, ASN103N, ASN172G, ASP104N, ASP106N, ASP175G, ASP179G, ASP185G, GLN181G, GLU187G, ILE115N, ILE126G, ILE184G, ILE189G, ILE192G, LEU102N, LEU112N, LEU173G, LEU188G, LEU84G, LYS109N, LYS114N, LYS116N, LYS171G, LYS177G, LYS178G, LYS182G, LYS190G, MET111N, PHE105N, PHE108N, PHE176G, PRO174G, THR170G, THR76G, VAL110N
• G-j: ALA186G, ALA87j, ARG77j, ARG86j, ASN121G, ASN81j, ASP185G, GLN100G, GLN122G, GLN35j, GLN98G, GLU187G, GLY102G, GLY80j, GLY83j, HIS79j, ILE184G, LEU103G, LEU104G, LEU188G, LEU18j, LEU33j, LEU34j, LEU99G, LYS182G, LYS42j, LYS70G, PRO78j, SER101G, SER32j, SER82j, THR74G, VAL120G, VAL183G, VAL45j, VAL84j, VAL85j
• G-e: ARG16G, GLN30e, ILE11G, LYS29e
• L-c: ALA121c, ARG118c, GLN117c, HIS114c, LYS119c, PHE115c, PHE120c, PRO116c, THR112c, UNK105L, UNK106L, UNK107L, UNK108L, UNK109L, UNK110L, UNK111L, UNK123L, UNK125L, UNK50L, UNK51L, UNK52L, UNK53L, UNK54L, UNK55L, UNK56L, UNK57L, UNK59L, UNK60L, UNK61L, UNK62L, VAL113c
• N-S: ALA104S, ALA13N, ALA36N, ALA3S, ARG11N, ARG156S, ARG159S, ARG163S, ARG35N, ARG45N, ARG52N, ARG5N, ARG5S, ARG64N, ARG97S, ASN102S, ASN140S, ASN16N, ASN34N, ASN49N, ASN70S, ASN76S, ASP148S, ASP29N, ASP32N, ASP39N, ASP57N, ASP98S, CYS46N, GLN107S, GLN143S, GLN33N, GLN47N, GLU106S, GLU111S, GLU68S, GLU8N, GLY103S, GLY10N, GLY2S, GLY90N, HIS145S, ILE149S, ILE27N, ILE48N, ILE58N, ILE60N, ILE62N, ILE74S, ILE9N, LEU14N, LEU153S, LEU165S, LEU37N, LEU53N, LEU55N, LYS142S, LYS146S, LYS150S, LYS157S, LYS164S, LYS166S, LYS19N, LYS4N, LYS51N, LYS59N, LYS63N, LYS67N, LYS75S, LYS91N, MET1N, MET1S, PHE144S, PHE151S, PHE3N, PHE50N, PHE6N, PRO152S, PRO160S, PRO161S, PRO2N, PRO66N, PRO71S, SER147S, SER54N, THR100S, THR110S, THR141S, THR162S, THR167S, THR56N, THR72S, THR73S, THR99S, TRP89N, TYR155S, TYR77S, TYR96S, VAL12N, VAL154S, VAL158S, VAL28N, VAL30N, VAL31N, VAL38N, VAL44N, VAL65N, VAL7N
• N-j: ALA100N, ARG10j, ARG23N, ARG4j, ARG52N, ARG8j, ARG99N, ASN103N, ASN16N, ASN81j, ASP104N, GLN5j, GLN7j, GLN96N, GLU43j, GLU44j, GLY18N, GLY22N, GLY3j, GLY46j, GLY90N, LEU102N, LEU14N, LEU53N, LEU93N, LYS2j, LYS42j, LYS51N, LYS92N, LYS97N, MET1N, MET1j, PHE105N, PHE108N, PHE3N, PRO2N, SER101N, SER54N, THR41j, TRP47j, TYR17N, TYR21N, VAL15N, VAL45j
• N-K: ALA202K, ARG117N, ARG98N, ARG99N, GLU124N, GLU192K, GLU199K, LEU201K, LYS114N, LYS129N, LYS185K, LYS193K, LYS205K, TYR206K
• S-j: LYS164S, MET1j
• S-e: ALA129S, ALA229e, ALA39S, ALA54e, ALA62S, ALA71e, ARG130e, ARG14S, ARG232e, ARG28S, ARG38S, ARG69e, ARG72e, ASN127e, ASN221e, ASN231e, ASN234e, ASN35S, ASN57S, ASN64S, ASN70S, ASP228e, ASP61e, CYS122S, GLN10S, GLN124S, GLN238e, GLN59S, GLN66e, GLN8S, GLU133e, GLU225e, GLU233e, GLU36S, GLU63e, GLU65S, GLU68S, GLU70e, GLU82e, GLY139e, GLY13S, GLY15S, GLY226e, GLY227e, GLY58S, GLY75e, GLY76e, HIS222e, ILE123S, ILE126S, ILE126e, ILE236e, ILE26S, ILE60S, ILE63S, ILE66S, LEU101S, LEU16S, LEU31S, LEU50S, LEU61S, LEU64e, LEU67e, LEU86e, LYS123e, LYS127S, LYS217e, LYS218e, LYS25S, LYS30S, LYS40S, LYS42S, LYS54S, LYS55S, LYS68e, LYS69S, LYS74e, MET29S, MET73e, PHE120S, PHE43S, PHE46S, PHE4S, PHE67S, PHE6S, PHE77e, PRO121S, PRO71S, PRO81e, SER41S, SER56S, SER80e, THR128S, THR130S, THR34S, TRP32S, TRP44S, TYR138e, TYR140e, TYR223e, TYR235e, TYR27S, TYR45S, TYR57e, TYR78e, TYR9S, VAL11S, VAL12S, VAL224e, VAL37S, VAL65e, VAL79e
• a-i: ALA14i, ALA23a, ALA39i, ALA44a, ALA47a, ARG10i, ARG38i, ARG64i, ARG66i, ARG67a, ARG69i, ARG71i, ARG84a, ASN18i, ASN70i, ASN76a, ASP88a, CYS44i, CYS70a, GLN19i, GLN33i, GLN3i, GLN52i, GLY41i, GLY45a, GLY48i, HIS79a, ILE25a, ILE51i, LEU46a, LEU67i, LEU72a, LEU74a, LEU80a, LEU87a, LYS22a, LYS36i, LYS37i, LYS43i, LYS48a, LYS49i, LYS50i, LYS51a, LYS52a, LYS73a, LYS92a, MET81a, PHE71a, PHE77a, PRO42i, PRO45i, PRO50a, PRO65i, PRO82a, SER40i, SER66a, SER68i, THR20i, THR35i, THR47i, THR78a, THR83a, THR86a, TYR13i, TYR32i, TYR34i, TYR49a, TYR7i, TYR85a, VAL24a, VAL26a, VAL46i, VAL75a, VAL89a
• a-p: ARG30p, ARG36a, PRO37a, TYR13p, TYR38a
• a-x: ARG84a, ASN76a, HIS79a, LEU87a, THR83a, THR86a, UNK14x, UNK18x, UNK1x, UNK2x, UNK3x, UNK6x, UNK7x, UNK8x, VAL75a
• i-x: ALA14i, LEU107i, LYS36i, LYS37i, UNK14x, UNK17x, UNK18x, UNK19x, UNK20x
• j-K: ARG69j, ARG90j, ARG99K, LEU33K
• J-s: ALA123J, ARG118J, ARG49s, ASN119J, ASN39s, GLN42s, GLU125J, GLU43s, GLY50s, ILE53s, LYS124J, LYS46s, MET122J, SER121J
• t-u: ASP17u, ASP18u, GLY19u, GLY63t, HIS16u, LEU60u, LYS52t, SER61t, VAL62t
• t-v: ALA10v, ALA11t, ALA12t, ALA28t, ALA33t, ALA34t, ALA5v, ALA6v, ALA7t, ASN15v, ASP17t, ASP18t, ASP22v, CYS32v, CYS8t, GLU21v, GLU25t, GLU28v, GLY14v, GLY19t, GLY31v, GLY35t, HIS16t, ILE14t, ILE20t, ILE26v, ILE27t, ILE36t, ILE4v, ILE59t, LEU10t, LEU12v, LEU13t, LEU15t, LEU23v, LEU27v, LEU55v, LEU8v, LEU9v, LYS26t, LYS2v, LYS32t, LYS37t, MET1v, PHE3v, SER13v, SER25v, SER29v, THR24v, THR29t, THR9t, TYR11v, TYR7v, VAL30t, VAL30v, VAL31t, VAL6t
• t-w: ALA40t, ALA44t, ALA47t, ARG53t, ARG59w, ASN36w, ASP35w, CYS32w, CYS8t, GLN45w, GLU33w, GLU37w, GLU39t, GLU40w, GLU51t, GLY63t, ILE34w, LEU27w, LEU41w, LEU43w, LEU45t, LEU49t, LEU50t, LEU58t, LYS2w, LYS38w, LYS48t, LYS52t, MET1w, MET39w, MET42w, PHE3w, PHE46t, PRO43t, SER19w, SER44w, SER61t, TRP42t, TYR41t, VAL62t, VAL6t
• t-s: ALA11t, ALA12t, ALA226s, ALA231s, ALA238s, ALA239s, ALA240s, ALA44t, ALA47t, ALA7t, ARG53t, ASN246s, ASP17t, ASP56t, ASP57t, CYS8t, GLY221s, GLY63t, HIS16t, HIS242s, ILE14t, ILE22t, ILE232s, ILE237s, ILE27t, ILE36t, ILE59t, LEU10t, LEU13t, LEU230s, LEU45t, LEU49t, LEU50t, LEU58t, LEU60t, LYS249s, MET224s, MET243s, PHE218s, PHE46t, PRO235s, PRO43t, SER220s, SER223s, SER227s, SER229s, SER233s, SER54t, SER61t, THR236s, THR9t, TRP42t, TYR234s, TYR41t, VAL222s, VAL225s, VAL228s, VAL55t, VAL62t, VAL6t
• u-w: ALA10w, ALA11u, ALA12u, ALA28u, ALA33u, ALA34u, ALA5w, ALA6w, ALA7u, ASN15w, ASP17u, ASP18u, ASP22w, CYS32w, CYS8u, GLU21w, GLU25u, GLU28w, GLU33w, GLY14w, GLY19u, GLY31w, GLY35u, HIS16u, ILE14u, ILE20u, ILE26w, ILE27u, ILE34w, ILE36u, ILE4w, ILE59u, LEU10u, LEU12w, LEU13u, LEU15u, LEU23w, LEU27w, LEU55w, LEU8w, LEU9w, LYS26u, LYS2w, LYS32u, LYS37u, MET1w, PHE3w, SER13w, SER25w, SER29w, THR24w, THR29u, THR9u, TYR11w, TYR7w, VAL30u, VAL30w, VAL31u, VAL6u
• u-s: ALA11u, ALA12u, ALA253s, ALA255s, ALA7u, ARG53u, ASN246s, ASN250s, ASP17u, ASP56u, ASP57u, CYS8u, GLU257s, GLU259s, GLY247s, GLY63u, ILE14u, ILE22u, ILE59u, LEU10u, LEU13u, LEU252s, LEU45u, LEU49u, LEU50u, LEU58u, LEU60u, LYS249s, LYS48u, LYS52u, PHE244s, PHE46u, PRO43u, SER261s, SER54u, SER61u, THR258s, THR9u, TRP42u, TYR248s, TYR260s, TYR262s, TYR41u, VAL251s, VAL254s, VAL256s, VAL55u, VAL62u, VAL6u
• v-s: ALA219s, ALA226s, ALA238s, ALA56v, ALA57v, ALA5v, ARG102s, ARG59v, ASN36v, ASP197s, ASP208s, ASP212s, ASP213s, ASP35v, ASP50v, ASP97s, GLN45v, GLU100s, GLU103s, GLU205s, GLU211s, GLU216s, GLU37v, GLU40v, GLU53v, GLY199s, GLY221s, GLY58v, ILE237s, ILE4v, ILE51v, LEU12v, LEU207s, LEU209s, LEU214s, LEU41v, LEU43v, LEU54v, LEU55v, LEU8v, LEU98s, LEU9v, LYS217s, LYS27s, LYS38v, LYS47v, LYS49v, LYS99s, MET1v, MET215s, MET224s, MET39v, MET42v, PHE202s, PHE218s, PHE3v, SER198s, SER19v, SER200s, SER203s, SER220s, SER223s, SER229s, SER44v, THR210s, THR236s, THR52v, TYR11v, TYR234s, TYR7v, VAL101s, VAL195s, VAL201s, VAL206s, VAL222s, VAL225s, VAL46v
• w-s: ALA226s, ALA231s, ALA238s, ALA239s, ALA240s, ALA56w, ALA57w, ALA5w, ALA6w, ARG59w, ASN246s, ASN250s, ASP50w, GLN45w, GLU37w, GLU53w, GLY247s, GLY58w, HIS242s, ILE232s, ILE237s, ILE4w, ILE51w, LEU12w, LEU230s, LEU245s, LEU252s, LEU41w, LEU54w, LEU55w, LEU8w, LEU9w, LYS249s, LYS38w, LYS49w, MET1w, MET243s, MET42w, PHE244s, PHE3w, PRO235s, PRO241s, SER227s, SER229s, SER233s, SER44w, THR236s, THR52w, TYR11w, TYR234s, TYR248s, TYR262s, TYR7w, VAL228s, VAL251s, VAL46w
• e-D: ALA39e, ARG147e, ARG355D, ASN167e, ASP185e, GLN405D, GLN66e, GLU184e, GLU357D, GLU35e, GLU41e, LEU67e, LYS169e, LYS29e, LYS342D, LYS356D, LYS358D, LYS362D, LYS365D, LYS36e, LYS44e, LYS68e, THR404D
• C-K: ARG159K, ARG97C, ASP156K, GLU111K, GLU160K, GLU163K, LYS94C