3IYL

atomic cryoem structure of a nonenveloped virus suggests how membrane penetration protein is primed for cell entry

• Total interactions analyzed: 300
• Total true interactions: 85
• Strongest Interaction:
  • Chains: I-J
  • Int. Res.: 156
  • Norm. En. per Res.: -3.7333
• Hub Node: C(8)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-62.3812	-6.9746	-511.097	-580.4529	156	62	10	20903	0	9	10
A-I	0.0	0.0	-0.0898	-0.0898	4	0	0	24	0	0	0
B-I	0.0	0.0	-2.7979	-2.7979	13	0	0	220	0	0	0
B-J	0.0	-14.8104	-9.5404	-24.3508	22	0	0	748	1	5	4
C-D	-61.4732	-6.9728	-512.753	-581.1991	156	62	10	20909	0	9	10
C-E	0.0	5.5173	-46.1602	-40.6429	19	3	1	1739	0	2	2
C-F	-7.9008	-9.1546	-21.5299	-38.5853	42	6	0	1778	0	3	3
C-G	0.0	5.5165	-46.3996	-40.8831	19	3	1	1823	0	2	2
C-H	-7.2835	0.0	-115.135	-122.4185	58	30	9	7483	0	4	2
C-I	0.0	0.0	-0.0366	-0.0366	4	0	0	14	0	0	0
C-J	0.0	0.0	-1.6126	-1.6126	10	0	0	167	0	0	0
C-L	0.0	0.0	-0.1123	-0.1123	5	0	0	27	0	0	0
D-E	-7.2774	0.0	-114.766	-122.0434	58	30	9	7463	0	4	2
D-F	-148.5719	-178.8156	-818.037	-1145.4245	454	194	31	49913	10	102	73
D-G	0.0	-9.152	-17.9881	-27.1401	46	6	0	1870	0	3	3
D-H	-132.1427	-180.8042	-816.526	-1129.4729	454	189	31	49971	10	103	72
D-J	0.0	-14.767	-7.7107	-22.4777	20	0	0	623	0	5	4
D-K	-6.8166	0.0	-3.7096	-10.5262	10	3	0	245	0	0	0
D-L	-29.0808	31.0903	-68.9569	-66.9475	52	8	0	3648	0	8	8
D-N	0.0	0.0	-0.0023	-0.0023	3	0	0	3	0	1	1
E-F	-53.747	-6.9742	-515.943	-576.6642	156	59	10	20935	0	9	10
E-G	0.0	5.5172	-46.1555	-40.6383	19	3	1	1739	0	2	2
E-H	-7.8889	-9.1548	-21.0477	-38.0914	42	6	0	1755	0	3	3
F-G	-7.205	0.0	-117.033	-124.238	58	26	9	7713	0	4	2
F-H	-147.7836	-182.9983	-842.259	-1173.0408	454	179	31	49707	10	102	73
F-L	0.0	0.0	-0.015	-0.015	3	0	0	13	0	1	1
F-N	0.0	0.0	-11.0338	-11.0338	33	11	1	2326	0	0	3
G-H	-49.1413	-6.9726	-487.161	-543.2749	155	53	10	20758	0	9	10
G-K	0.0	0.0	-0.6273	-0.6273	5	0	0	87	0	0	0
G-L	0.0	0.0	-0.0027	-0.0027	2	0	0	2	0	1	1
H-K	0.0	0.0	-2.6973	-2.6973	18	2	1	474	0	0	0
H-L	0.0	-16.5066	-14.1218	-30.6284	27	3	1	1250	1	5	6
I-J	-63.528	-6.9741	-511.895	-582.3972	156	62	10	20898	0	9	10
I-K	0.0	5.5174	-46.171	-40.6536	19	3	1	1739	0	2	2
I-L	-7.899	-9.1539	-22.3008	-39.3536	42	6	0	1788	0	3	3
I-M	0.0	5.5165	-46.412	-40.8955	19	3	1	1826	0	2	2
I-N	-7.2859	0.0	-115.138	-122.4239	58	30	9	7483	0	4	2
J-K	-7.2793	0.0	-114.796	-122.0753	58	30	9	7461	0	4	2
J-L	-149.4366	-193.7203	-832.978	-1176.1349	454	183	31	49823	10	102	73
J-M	0.0	-9.1522	-18.4803	-27.6325	44	6	0	1759	0	3	3
J-N	-131.8706	-182.3088	-823.576	-1137.7554	454	187	31	49950	10	102	73
J-R	0.0	0.0	-0.0276	-0.0276	3	0	0	19	0	1	1
J-T	0.0	0.0	-32.1065	-32.1065	32	5	1	1877	0	0	3
J-V	0.0	-6.1073			2
K-L	-53.7155	-6.9737	-516.079	-576.7681	156	59	10	20945	0	9	10
K-M	0.0	5.5172	-46.159	-40.6418	19	3	1	1739	0	2	2
K-N	-7.8889	-9.1545	-17.513	-34.5564	42	6	0	1755	0	3	3
K-Q	0.0	0.0	-1.3537	-1.3537	8	0	0	134	0	0	0
K-R	0.0	0.0	-0.0033	-0.0033	2	0	0	2	0	1	1
L-M	-7.205	0.0	-117.174	-124.379	58	26	9	7718	0	4	2
L-N	-146.3947	-196.882	-837.398	-1180.6746	453	180	31	49699	10	102	73
L-Q	0.0	0.0	26.6653	26.6653	20	10	1	681	0	0	0
L-R	0.0	-18.3398	-3.3996	-21.7394	35	5	1	1481	1	5	6
M-N	-48.6374	-6.9733	-486.813	-542.4237	155	53	10	20755	0	9	10
M-O	0.0	0.0	-0.0055	-0.0055	2	0	0	4	0	0	0
M-P	0.0	0.0	-0.523	-0.523	10	0	0	83	0	0	0
M-R	0.0	0.0	-0.0578	-0.0578	3	0	0	19	0	0	0
N-P	0.0	-15.4056	-3.7609	-19.1665	18	0	0	387	0	4	4
N-Q	0.0	0.0	-2.0627	-2.0627	10	0	0	225	0	0	0
N-R	-7.6871	30.5588	-65.1206	-42.2489	53	7	0	3627	0	8	8
O-P	-57.5704	-6.9737	-508.154	-572.6981	156	61	10	20874	0	9	10
O-Q	0.0	5.5173	-46.1734	-40.6561	19	3	1	1739	0	2	2
O-R	-7.902	-9.1532	-21.0496	-38.1048	42	6	0	1758	0	3	3
O-S	0.0	5.5168	-46.412	-40.8952	19	3	1	1824	0	2	2
O-T	-7.274	0.0	-115.888	-123.162	58	31	9	7496	0	4	2
P-Q	-7.2835	0.0	-114.767	-122.0505	58	30	9	7463	0	4	2
P-R	-148.715	-183.0617	-821.795	-1153.5717	453	186	31	49744	10	102	73
P-S	0.0	-9.1524	-20.4657	-29.6181	42	6	0	1752	0	3	3
P-T	-134.8085	-183.973	-848.813	-1167.5946	455	191	31	50029	10	102	73
P-U	0.0	0.0	-11.2805	-11.2805	21	0	0	518	0	1	1
P-W	-12.1082	-17.9539			2
Q-R	-50.8587	-6.9763	-514.083	-571.918	156	59	10	20918	0	9	10
Q-S	0.0	5.5172	-46.163	-40.6458	19	3	1	1739	0	2	2
Q-T	-7.9022	-9.1543	-20.2595	-37.316	42	7	0	1762	0	3	3
R-S	-7.1977	0.0	-117.133	-124.3307	58	26	9	7708	0	4	2
R-T	-146.8146	-189.0812	-831.322	-1167.2179	454	190	31	49950	10	102	73
R-W	-4.7078	5.4594			4
S-T	-46.4907	-6.9729	-485.509	-538.9726	155	55	10	20769	0	9	10
T-W	-3.6476	-24.7019			10
U-W	0.0	-10.6725			7
U-X	-64.8548	-40.0			32
V-X	-18.0281	-2.2276			8
V-Y	-52.6178	-9.7205			17
W-X	-12.2934	-40.9894			11
X-Y	-84.9844	-54.962			41

Interface residues

• A-B: ALA176B, ALA179B, ALA188B, ALA190B, ALA211B, ALA217B, ALA230B, ALA232B, ALA239B, ALA241B, ALA244B, ALA245B, ALA30A, ALA31A, ALA33A, ALA85B, ALA98B, ARG214B, ARG627B, ARG79B, ASN12A, ASN182B, ASN18A, ASN205B, ASN209B, ASN222B, ASN243B, ASN3A, ASN42A, ASN75B, ASN9A, ASP16A, ASP173B, ASP224B, ASP229B, ASP25A, ASP35A, ASP88B, CYS181B, CYS200B, GLN146B, GLN160B, GLN231B, GLN5A, GLN628B, GLN635B, GLN93B, GLN97B, GLU206B, GLU237B, GLU80B, GLY15A, GLY177B, GLY17A, GLY221B, GLY236B, GLY240B, GLY2A, GLY45B, GLY77B, HIS213B, HIS233B, ILE13A, ILE142B, ILE149B, ILE174B, ILE212B, ILE34A, ILE641B, ILE89B, LEU145B, LEU163B, LEU170B, LEU186B, LEU187B, LEU201B, LEU218B, LEU227B, LEU235B, LEU36A, LEU41A, LEU624B, LEU86B, LEU95B, LYS100B, LYS184B, LYS191B, LYS219B, LYS226B, LYS37A, LYS46B, LYS634B, LYS84B, MET153B, MET167B, MET26A, MET78B, MET91B, PHE207B, PHE20A, PHE242B, PHE637B, PHE638B, PHE73B, PHE82B, PHE87B, PHE96B, PRO172B, PRO204B, PRO216B, PRO220B, PRO223B, PRO228B, PRO22A, PRO234B, PRO32A, PRO94B, SER175B, SER178B, SER180B, SER19A, SER247B, SER24A, SER28A, SER72B, SER7A, SER83B, THR10A, THR14A, THR168B, THR171B, THR202B, THR21A, THR225B, THR23A, THR246B, THR27A, THR29A, THR44B, THR631B, THR6A, THR81B, THR99B, TRP183B, TRP92B, TYR11A, TYR203B, TYR208B, TYR215B, VAL210B, VAL238B, VAL253B, VAL40A, VAL4A, VAL74B, VAL8A
• A-I: ASN3I, PRO22A, THR21A, THR23A
• B-I: ALA179B, ALA230B, ASN3I, GLN231B, GLN5I, GLY177B, ILE174B, LYS219B, SER178B, SER180B, THR6I, VAL4I, VAL8I
• B-J: ALA176B, ARG625B, ASN198J, ASP197J, GLN628B, GLU248B, GLU622B, GLY177B, LEU196J, LEU199J, LEU201J, LEU624B, LYS100J, SER178B, SER247B, SER621B, SER629B, THR202J, THR631B, THR99J, TYR203J, VAL632B
• C-D: ALA176D, ALA179D, ALA188D, ALA190D, ALA211D, ALA217D, ALA230D, ALA232D, ALA239D, ALA241D, ALA244D, ALA245D, ALA30C, ALA31C, ALA33C, ALA85D, ALA98D, ARG214D, ARG627D, ARG79D, ASN12C, ASN182D, ASN18C, ASN205D, ASN209D, ASN222D, ASN243D, ASN3C, ASN42C, ASN75D, ASN9C, ASP16C, ASP173D, ASP224D, ASP229D, ASP25C, ASP35C, ASP88D, CYS181D, CYS200D, GLN146D, GLN160D, GLN231D, GLN5C, GLN628D, GLN635D, GLN93D, GLN97D, GLU206D, GLU237D, GLU80D, GLY15C, GLY177D, GLY17C, GLY221D, GLY236D, GLY240D, GLY2C, GLY45D, GLY77D, HIS213D, HIS233D, ILE13C, ILE142D, ILE149D, ILE174D, ILE212D, ILE34C, ILE641D, ILE89D, LEU145D, LEU163D, LEU170D, LEU186D, LEU187D, LEU201D, LEU218D, LEU227D, LEU235D, LEU36C, LEU41C, LEU624D, LEU86D, LEU95D, LYS100D, LYS184D, LYS191D, LYS219D, LYS226D, LYS37C, LYS46D, LYS634D, LYS84D, MET153D, MET167D, MET26C, MET78D, MET91D, PHE207D, PHE20C, PHE242D, PHE637D, PHE638D, PHE73D, PHE82D, PHE87D, PHE96D, PRO172D, PRO204D, PRO216D, PRO220D, PRO223D, PRO228D, PRO22C, PRO234D, PRO32C, PRO94D, SER175D, SER178D, SER180D, SER19C, SER247D, SER24C, SER28C, SER72D, SER7C, SER83D, THR10C, THR14C, THR168D, THR171D, THR202D, THR21C, THR225D, THR23C, THR246D, THR27C, THR29C, THR44D, THR631D, THR6C, THR81D, THR99D, TRP183D, TRP92D, TYR11C, TYR203D, TYR208D, TYR215D, VAL210D, VAL238D, VAL253D, VAL40C, VAL4C, VAL74D, VAL8C
• C-E: ALA30C, ALA31C, ALA33C, ASN42E, ASP35C, ASP35E, GLY39E, ILE34C, LEU36C, LEU36E, LEU41E, LYS37E, PRO32C, PRO38E, SER28C, THR27C, THR29C, VAL40C, VAL40E
• C-F: ALA123F, ALA262F, ALA267F, ALA62F, ARG147F, ARG609F, ASP25C, ASP35C, GLN146F, GLN261F, GLN70F, GLY268F, GLY39C, GLY611F, ILE142F, ILE263F, ILE63F, LEU259F, LEU36C, LEU608F, LEU613F, LEU61F, LYS37C, LYS46F, MET143F, MET266F, MET26C, PRO38C, SER24C, SER256F, SER257F, SER260F, SER264F, SER612F, THR10C, THR139F, THR23C, THR265F, THR610F, TRP48F, TYR11C, VAL40C
• C-G: ALA30G, ALA31G, ALA33G, ASN42C, ASP35C, ASP35G, GLY39C, ILE34G, LEU36C, LEU36G, LEU41C, LYS37C, PRO32G, PRO38C, SER28G, THR27G, THR29G, VAL40C, VAL40G
• C-H: ALA239H, ALA241H, ALA262H, ALA30C, ALA31C, ALA33C, ALA607H, ARG609H, ASN243H, ASN42C, ASP35C, ASP88H, GLN261H, GLU237H, GLU80H, GLY236H, GLY240H, GLY254H, GLY39C, GLY605H, GLY611H, GLY614H, ILE263H, ILE34C, LEU235H, LEU252H, LEU259H, LEU36C, LEU41C, LEU608H, LEU613H, LYS37C, LYS615H, LYS84H, MET26C, MET91H, PHE242H, PHE87H, PRO22C, PRO32C, PRO38C, SER251H, SER255H, SER256H, SER257H, SER260H, SER264H, SER28C, SER612H, THR258H, THR27C, THR29C, THR606H, THR610H, THR81H, VAL238H, VAL253H, VAL40C
• C-I: ASN3C, PRO22I, THR21I, THR23I
• C-J: ALA179J, ALA230J, ASN3C, GLN231J, GLN5C, GLY177J, SER178J, SER180J, THR6C, VAL4C
• C-L: ARG147L, ARG67L, SER7C, THR6C, VAL8C
• D-E: ALA239D, ALA241D, ALA262D, ALA30E, ALA31E, ALA33E, ALA607D, ARG609D, ASN243D, ASN42E, ASP35E, ASP88D, GLN261D, GLU237D, GLU80D, GLY236D, GLY240D, GLY254D, GLY39E, GLY605D, GLY611D, GLY614D, ILE263D, ILE34E, LEU235D, LEU252D, LEU259D, LEU36E, LEU41E, LEU608D, LEU613D, LYS37E, LYS615D, LYS84D, MET26E, MET91D, PHE242D, PHE87D, PRO22E, PRO32E, PRO38E, SER251D, SER255D, SER256D, SER257D, SER260D, SER264D, SER28E, SER612D, THR258D, THR27E, THR29E, THR606D, THR610D, THR81D, VAL238D, VAL253D, VAL40E
• D-F: ALA121F, ALA123F, ALA126F, ALA150F, ALA151F, ALA157F, ALA166F, ALA190F, ALA211F, ALA217F, ALA230D, ALA232D, ALA239D, ALA239F, ALA241D, ALA244D, ALA244F, ALA245D, ALA245F, ALA267D, ALA276D, ALA290D, ALA297F, ALA304F, ALA400D, ALA402D, ALA404F, ALA408D, ALA483D, ALA487D, ALA499F, ALA501F, ALA503D, ALA518F, ALA524F, ALA528F, ALA535D, ALA538D, ALA544D, ALA572F, ALA573F, ALA599D, ALA607D, ALA620D, ALA620F, ALA626F, ALA633F, ALA636F, ALA85D, ALA85F, ARG147F, ARG152F, ARG154F, ARG214F, ARG292D, ARG295D, ARG295F, ARG337F, ARG412D, ARG416D, ARG416F, ARG428D, ARG472D, ARG530D, ARG530F, ARG542D, ARG567F, ARG571F, ARG609D, ARG625F, ARG627F, ARG67F, ARG79D, ARG79F, ASN129F, ASN144F, ASN198F, ASN222D, ASN243D, ASN243F, ASN363F, ASN406D, ASN410D, ASN418D, ASN453F, ASN456F, ASN504D, ASN512F, ASN515F, ASN519F, ASN579F, ASN75F, ASN90D, ASP125F, ASP128F, ASP155F, ASP164F, ASP173F, ASP192F, ASP197F, ASP229D, ASP270D, ASP272D, ASP277D, ASP303F, ASP346D, ASP352D, ASP461F, ASP482D, ASP523F, ASP532D, ASP532F, ASP533D, ASP561D, ASP619D, ASP619F, ASP639F, ASP66F, ASP88D, ASP88F, GLN141F, GLN146F, GLN160F, GLN231D, GLN261D, GLN261F, GLN330F, GLN414D, GLN414F, GLN423D, GLN546D, GLN551D, GLN585F, GLN628F, GLN640F, GLN70F, GLN93D, GLN97D, GLU237D, GLU248D, GLU275D, GLU302F, GLU309F, GLU427D, GLU429D, GLU473D, GLU496F, GLU497F, GLU622F, GLU76D, GLU76F, GLU80D, GLU80F, GLY104D, GLY120F, GLY124F, GLY236D, GLY240D, GLY240F, GLY250D, GLY250F, GLY254F, GLY268D, GLY332F, GLY334F, GLY355D, GLY355F, GLY401D, GLY413D, GLY441F, GLY45F, GLY462F, GLY522F, GLY553D, GLY587F, GLY595D, GLY603D, GLY605D, GLY611D, GLY614D, GLY616D, GLY642F, GLY69F, GLY77D, GLY77F, HIS162F, HIS213D, HIS213F, HIS233D, HIS421D, HIS547D, ILE106D, ILE137F, ILE142F, ILE149F, ILE174F, ILE193F, ILE263D, ILE274D, ILE299F, ILE307F, ILE345D, ILE357D, ILE357F, ILE409D, ILE445F, ILE484D, ILE525D, ILE525F, ILE539D, ILE588F, ILE58F, ILE63F, ILE641F, ILE89D, ILE89F, LEU108D, LEU108F, LEU127F, LEU145F, LEU158F, LEU163F, LEU170F, LEU186F, LEU194F, LEU196F, LEU235D, LEU252D, LEU252F, LEU259D, LEU259F, LEU271D, LEU273D, LEU280D, LEU289D, LEU358F, LEU366F, LEU407D, LEU420D, LEU422D, LEU459F, LEU463D, LEU470D, LEU471D, LEU47F, LEU509D, LEU514F, LEU517F, LEU543D, LEU549D, LEU565D, LEU582F, LEU591F, LEU597D, LEU600D, LEU608D, LEU613D, LEU624F, LEU630F, LEU644F, LEU86D, LEU86F, LYS161F, LYS191F, LYS269D, LYS300F, LYS46F, LYS516D, LYS516F, LYS548D, LYS570F, LYS615D, LYS615F, LYS623F, LYS634F, LYS84D, LYS84F, MET143F, MET153F, MET167F, MET169F, MET266D, MET419D, MET460F, MET575F, MET78F, MET91D, MET91F, PHE189F, PHE242D, PHE285D, PHE298F, PHE417D, PHE417F, PHE426D, PHE443F, PHE454F, PHE576F, PHE637F, PHE638F, PHE68F, PHE73F, PHE82F, PHE87D, PHE96D, PRO105D, PRO130F, PRO172F, PRO195F, PRO216D, PRO216F, PRO220D, PRO234D, PRO279D, PRO281D, PRO287D, PRO291D, PRO296F, PRO301F, PRO333F, PRO335F, PRO359F, PRO371F, PRO415D, PRO415F, PRO43F, PRO457F, PRO468D, PRO486D, PRO526D, PRO526F, PRO560D, PRO563D, PRO580F, PRO589F, PRO646F, PRO94D, SER109D, SER110D, SER138F, SER175F, SER247D, SER251F, SER255D, SER255F, SER256F, SER257F, SER260D, SER260F, SER264D, SER283D, SER288D, SER347D, SER354D, SER452F, SER455F, SER495F, SER500F, SER511F, SER529D, SER529F, SER534D, SER537D, SER541D, SER550D, SER574F, SER578F, SER581F, SER594D, SER598D, SER602D, SER612D, SER621D, SER621F, SER629F, SER643F, SER65F, SER72F, SER83D, THR122F, THR139F, THR148F, THR165F, THR168F, THR171F, THR246D, THR258F, THR265D, THR278D, THR286D, THR336F, THR350D, THR356D, THR356F, THR362F, THR425D, THR430D, THR442F, THR44F, THR458F, THR465D, THR467D, THR494F, THR531D, THR531F, THR536D, THR536F, THR601D, THR606D, THR610D, THR618D, THR618F, THR631F, THR81F, TRP159F, TRP48F, TRP566D, TRP645F, TRP92D, TRP92F, TYR215F, TYR294F, TYR360D, TYR360F, TYR562D, TYR71F, VAL107D, VAL119F, VAL140F, VAL156F, VAL238D, VAL249D, VAL253F, VAL282D, VAL284D, VAL348D, VAL353D, VAL353F, VAL411D, VAL466D, VAL469D, VAL485D, VAL498F, VAL520F, VAL521F, VAL527F, VAL540D, VAL545D, VAL552D, VAL577F, VAL586F, VAL604D, VAL617D, VAL74F
• D-G: ALA123D, ALA262D, ALA267D, ALA62D, ARG147D, ARG609D, ASP25G, ASP35G, ASP59D, GLN146D, GLN261D, GLN70D, GLY268D, GLY39G, GLY611D, ILE142D, ILE263D, ILE63D, LEU259D, LEU36G, LEU608D, LEU613D, LEU61D, LYS37G, LYS46D, MET143D, MET266D, MET26G, PRO38G, SER24G, SER256D, SER257D, SER260D, SER264D, SER612D, SER65D, SER7G, THR10G, THR139D, THR23G, THR265D, THR610D, TRP48D, TYR11G, VAL40G, VAL51D
• D-H: ALA121D, ALA123D, ALA126D, ALA150D, ALA151D, ALA157D, ALA166D, ALA190D, ALA211D, ALA217D, ALA230H, ALA232H, ALA239D, ALA239H, ALA241H, ALA244D, ALA244H, ALA245D, ALA245H, ALA267H, ALA276H, ALA290H, ALA297D, ALA304D, ALA400H, ALA402H, ALA404D, ALA408H, ALA483H, ALA487H, ALA499D, ALA501D, ALA503H, ALA518D, ALA524D, ALA528D, ALA535H, ALA538H, ALA544H, ALA572D, ALA573D, ALA599H, ALA607H, ALA620D, ALA620H, ALA626D, ALA633D, ALA636D, ALA85D, ALA85H, ARG147D, ARG152D, ARG154D, ARG214D, ARG292H, ARG295D, ARG295H, ARG337D, ARG412H, ARG416D, ARG416H, ARG428H, ARG472H, ARG530D, ARG530H, ARG542H, ARG567D, ARG571D, ARG609H, ARG625D, ARG627D, ARG67D, ARG79D, ARG79H, ASN129D, ASN144D, ASN198D, ASN222H, ASN243D, ASN243H, ASN363D, ASN406H, ASN410H, ASN418H, ASN453D, ASN456D, ASN504H, ASN512D, ASN515D, ASN519D, ASN579D, ASN75D, ASN90H, ASP125D, ASP128D, ASP155D, ASP164D, ASP173D, ASP192D, ASP197D, ASP229H, ASP270H, ASP272H, ASP277H, ASP303D, ASP346H, ASP352H, ASP461D, ASP482H, ASP523D, ASP532D, ASP532H, ASP533H, ASP561H, ASP619D, ASP619H, ASP639D, ASP66D, ASP88D, ASP88H, GLN141D, GLN146D, GLN160D, GLN231H, GLN261D, GLN261H, GLN330D, GLN414D, GLN414H, GLN423H, GLN546H, GLN551H, GLN585D, GLN628D, GLN640D, GLN70D, GLN93H, GLN97H, GLU237H, GLU248H, GLU275H, GLU302D, GLU309D, GLU427H, GLU429H, GLU473H, GLU496D, GLU497D, GLU622D, GLU76D, GLU76H, GLU80D, GLU80H, GLY104H, GLY120D, GLY124D, GLY236H, GLY240D, GLY240H, GLY250D, GLY250H, GLY254D, GLY268H, GLY332D, GLY334D, GLY355D, GLY355H, GLY401H, GLY413H, GLY441D, GLY45D, GLY462D, GLY522D, GLY553H, GLY587D, GLY595H, GLY603H, GLY605H, GLY611H, GLY614H, GLY616H, GLY642D, GLY69D, GLY77D, GLY77H, HIS162D, HIS213D, HIS213H, HIS233H, HIS421H, HIS547H, ILE106H, ILE137D, ILE142D, ILE149D, ILE174D, ILE193D, ILE263H, ILE274H, ILE299D, ILE307D, ILE345H, ILE357D, ILE357H, ILE409H, ILE445D, ILE484H, ILE525D, ILE525H, ILE539H, ILE588D, ILE58D, ILE63D, ILE641D, ILE89D, ILE89H, LEU108D, LEU108H, LEU127D, LEU145D, LEU158D, LEU163D, LEU170D, LEU186D, LEU194D, LEU196D, LEU235H, LEU252D, LEU252H, LEU259D, LEU259H, LEU271H, LEU273H, LEU280H, LEU289H, LEU358D, LEU366D, LEU407H, LEU420H, LEU422H, LEU459D, LEU463H, LEU470H, LEU471H, LEU47D, LEU509H, LEU514D, LEU517D, LEU543H, LEU549H, LEU565H, LEU582D, LEU591D, LEU597H, LEU600H, LEU608H, LEU613H, LEU624D, LEU630D, LEU644D, LEU86D, LEU86H, LYS161D, LYS191D, LYS269H, LYS300D, LYS46D, LYS516D, LYS516H, LYS548H, LYS570D, LYS615D, LYS615H, LYS623D, LYS634D, LYS84D, LYS84H, MET143D, MET153D, MET167D, MET169D, MET266H, MET419H, MET460D, MET575D, MET78D, MET91D, MET91H, PHE189D, PHE242H, PHE285H, PHE298D, PHE417D, PHE417H, PHE426H, PHE443D, PHE454D, PHE576D, PHE637D, PHE638D, PHE68D, PHE73D, PHE82D, PHE87H, PHE96H, PRO105H, PRO130D, PRO172D, PRO195D, PRO216D, PRO216H, PRO220H, PRO234H, PRO279H, PRO281H, PRO287H, PRO291H, PRO296D, PRO301D, PRO333D, PRO335D, PRO359D, PRO371D, PRO415D, PRO415H, PRO43D, PRO457D, PRO468H, PRO486H, PRO526D, PRO526H, PRO560H, PRO563H, PRO580D, PRO589D, PRO646D, PRO94H, SER109H, SER110H, SER138D, SER175D, SER247H, SER251D, SER255D, SER255H, SER256D, SER257D, SER260D, SER260H, SER264H, SER283H, SER288H, SER347H, SER354H, SER452D, SER455D, SER495D, SER500D, SER511D, SER529D, SER529H, SER534H, SER537H, SER541H, SER550H, SER574D, SER578D, SER581D, SER594H, SER598H, SER602H, SER612H, SER621D, SER621H, SER629D, SER643D, SER65D, SER72D, SER83H, THR122D, THR139D, THR148D, THR165D, THR168D, THR171D, THR246H, THR258D, THR265H, THR278H, THR286H, THR336D, THR350H, THR356D, THR356H, THR362D, THR425H, THR430H, THR442D, THR44D, THR458D, THR465H, THR467H, THR494D, THR531D, THR531H, THR536D, THR536H, THR601H, THR606H, THR610H, THR618D, THR618H, THR631D, THR81D, TRP159D, TRP48D, TRP566H, TRP645D, TRP92D, TRP92H, TYR215D, TYR294D, TYR360D, TYR360H, TYR562H, TYR71D, VAL107H, VAL119D, VAL140D, VAL156D, VAL238H, VAL249H, VAL253D, VAL282H, VAL284H, VAL348H, VAL353D, VAL353H, VAL411H, VAL466H, VAL469H, VAL485H, VAL498D, VAL520D, VAL521D, VAL527D, VAL540H, VAL545H, VAL552H, VAL577D, VAL586D, VAL604H, VAL617H, VAL74D
• D-J: ALA176J, ARG625J, ASN198D, ASP197D, GLN628J, GLU248J, GLU622J, GLY177J, LEU196D, LEU199D, LEU201D, LEU624J, LYS100D, SER247J, SER621J, SER629J, THR202D, THR99D, TYR203D, VAL632J
• D-K: ARG147D, ARG67D, ASN144D, GLN5K, MET143D, PHE68D, SER7K, THR6K, VAL140D, VAL8K
• D-L: ALA150D, ALA150L, ALA151D, ALA151L, ALA98D, ALA98L, ARG147D, ARG147L, ARG152D, ARG152L, ARG154D, ARG154L, ASN144D, ASN144L, ASP155D, ASP155L, CYS103D, CYS103L, GLN141D, GLN146D, GLN146L, GLN97D, GLN97L, GLY102D, GLY102L, GLY104D, GLY104L, ILE106D, ILE149D, ILE149L, LEU145D, LEU145L, LYS100D, LYS100L, MET143D, MET143L, PHE111D, PHE111L, PHE96D, PHE96L, THR101D, THR101L, THR148D, THR148L, THR202L, THR99D, THR99L, TRP159D, TRP159L, TYR203D, TYR203L, VAL140D
• D-N: ASP197D, LEU196D, THR278N
• E-F: ALA176F, ALA179F, ALA188F, ALA190F, ALA211F, ALA217F, ALA230F, ALA232F, ALA239F, ALA241F, ALA244F, ALA245F, ALA30E, ALA31E, ALA33E, ALA85F, ALA98F, ARG214F, ARG627F, ARG79F, ASN12E, ASN182F, ASN18E, ASN205F, ASN209F, ASN222F, ASN243F, ASN3E, ASN42E, ASN75F, ASN9E, ASP16E, ASP173F, ASP224F, ASP229F, ASP25E, ASP35E, ASP88F, CYS181F, CYS200F, GLN146F, GLN160F, GLN231F, GLN5E, GLN628F, GLN635F, GLN93F, GLN97F, GLU206F, GLU237F, GLU80F, GLY15E, GLY177F, GLY17E, GLY221F, GLY236F, GLY240F, GLY2E, GLY45F, GLY77F, HIS213F, HIS233F, ILE13E, ILE142F, ILE149F, ILE174F, ILE212F, ILE34E, ILE641F, ILE89F, LEU145F, LEU163F, LEU170F, LEU186F, LEU187F, LEU201F, LEU218F, LEU227F, LEU235F, LEU36E, LEU41E, LEU624F, LEU86F, LEU95F, LYS100F, LYS184F, LYS191F, LYS219F, LYS226F, LYS37E, LYS46F, LYS634F, LYS84F, MET153F, MET167F, MET26E, MET78F, MET91F, PHE207F, PHE20E, PHE242F, PHE637F, PHE638F, PHE73F, PHE82F, PHE87F, PHE96F, PRO172F, PRO204F, PRO216F, PRO220F, PRO223F, PRO228F, PRO22E, PRO234F, PRO32E, PRO94F, SER175F, SER178F, SER180F, SER19E, SER247F, SER24E, SER28E, SER72F, SER7E, SER83F, THR10E, THR14E, THR168F, THR171F, THR202F, THR21E, THR225F, THR23E, THR246F, THR27E, THR29E, THR44F, THR631F, THR6E, THR81F, THR99F, TRP183F, TRP92F, TYR11E, TYR203F, TYR208F, TYR215F, VAL210F, VAL238F, VAL253F, VAL40E, VAL4E, VAL74F, VAL8E
• E-G: ALA30E, ALA31E, ALA33E, ASN42G, ASP35E, ASP35G, GLY39G, ILE34E, LEU36E, LEU36G, LEU41G, LYS37G, PRO32E, PRO38G, SER28E, THR27E, THR29E, VAL40E, VAL40G
• E-H: ALA123H, ALA262H, ALA267H, ALA62H, ARG147H, ARG609H, ASP25E, ASP35E, GLN146H, GLN261H, GLN70H, GLY268H, GLY39E, GLY611H, ILE142H, ILE263H, ILE63H, LEU259H, LEU36E, LEU608H, LEU613H, LEU61H, LYS37E, LYS46H, MET143H, MET266H, MET26E, PRO38E, SER24E, SER256H, SER257H, SER260H, SER264H, SER612H, THR10E, THR139H, THR23E, THR265H, THR610H, TRP48H, TYR11E, VAL40E
• F-G: ALA239F, ALA241F, ALA262F, ALA30G, ALA31G, ALA33G, ALA607F, ARG609F, ASN243F, ASN42G, ASP35G, ASP88F, GLN261F, GLU237F, GLU80F, GLY236F, GLY240F, GLY254F, GLY39G, GLY605F, GLY611F, GLY614F, ILE263F, ILE34G, LEU235F, LEU252F, LEU259F, LEU36G, LEU41G, LEU608F, LEU613F, LYS37G, LYS615F, LYS84F, MET26G, MET91F, PHE242F, PHE87F, PRO22G, PRO32G, PRO38G, SER251F, SER255F, SER256F, SER257F, SER260F, SER264F, SER28G, SER612F, THR258F, THR27G, THR29G, THR606F, THR610F, THR81F, VAL238F, VAL253F, VAL40G
• F-H: ALA121H, ALA123H, ALA126H, ALA150H, ALA151H, ALA157H, ALA166H, ALA190H, ALA211H, ALA217H, ALA230F, ALA232F, ALA239F, ALA239H, ALA241F, ALA244F, ALA244H, ALA245F, ALA245H, ALA267F, ALA276F, ALA290F, ALA297H, ALA304H, ALA400F, ALA402F, ALA404H, ALA408F, ALA483F, ALA487F, ALA499H, ALA501H, ALA503F, ALA518H, ALA524H, ALA528H, ALA535F, ALA538F, ALA544F, ALA572H, ALA573H, ALA599F, ALA607F, ALA620F, ALA620H, ALA626H, ALA633H, ALA636H, ALA85F, ALA85H, ARG147H, ARG152H, ARG154H, ARG214H, ARG292F, ARG295F, ARG295H, ARG337H, ARG412F, ARG416F, ARG416H, ARG428F, ARG472F, ARG530F, ARG530H, ARG542F, ARG567H, ARG571H, ARG609F, ARG625H, ARG627H, ARG67H, ARG79F, ARG79H, ASN129H, ASN144H, ASN198H, ASN222F, ASN243F, ASN243H, ASN363H, ASN406F, ASN410F, ASN418F, ASN453H, ASN456H, ASN504F, ASN512H, ASN515H, ASN519H, ASN579H, ASN75H, ASN90F, ASP125H, ASP128H, ASP155H, ASP164H, ASP173H, ASP192H, ASP197H, ASP229F, ASP270F, ASP272F, ASP277F, ASP303H, ASP346F, ASP352F, ASP461H, ASP482F, ASP523H, ASP532F, ASP532H, ASP533F, ASP561F, ASP619F, ASP619H, ASP639H, ASP66H, ASP88F, ASP88H, GLN141H, GLN146H, GLN160H, GLN231F, GLN261F, GLN261H, GLN330H, GLN414F, GLN414H, GLN423F, GLN546F, GLN551F, GLN585H, GLN628H, GLN640H, GLN70H, GLN93F, GLN97F, GLU237F, GLU248F, GLU275F, GLU302H, GLU309H, GLU427F, GLU429F, GLU473F, GLU496H, GLU497H, GLU622H, GLU76F, GLU76H, GLU80F, GLU80H, GLY104F, GLY120H, GLY124H, GLY236F, GLY240F, GLY240H, GLY250F, GLY250H, GLY254H, GLY268F, GLY332H, GLY334H, GLY355F, GLY355H, GLY401F, GLY413F, GLY441H, GLY45H, GLY462H, GLY522H, GLY553F, GLY587H, GLY595F, GLY603F, GLY605F, GLY611F, GLY614F, GLY616F, GLY642H, GLY69H, GLY77F, GLY77H, HIS162H, HIS213F, HIS213H, HIS233F, HIS421F, HIS547F, ILE106F, ILE137H, ILE142H, ILE149H, ILE174H, ILE193H, ILE263F, ILE274F, ILE299H, ILE307H, ILE345F, ILE357F, ILE357H, ILE409F, ILE445H, ILE484F, ILE525F, ILE525H, ILE539F, ILE588H, ILE58H, ILE63H, ILE641H, ILE89F, ILE89H, LEU108F, LEU108H, LEU127H, LEU145H, LEU158H, LEU163H, LEU170H, LEU186H, LEU194H, LEU196H, LEU235F, LEU252F, LEU252H, LEU259F, LEU259H, LEU271F, LEU273F, LEU280F, LEU289F, LEU358H, LEU366H, LEU407F, LEU420F, LEU422F, LEU459H, LEU463F, LEU470F, LEU471F, LEU47H, LEU509F, LEU514H, LEU517H, LEU543F, LEU549F, LEU565F, LEU582H, LEU591H, LEU597F, LEU600F, LEU608F, LEU613F, LEU624H, LEU630H, LEU644H, LEU86F, LEU86H, LYS161H, LYS191H, LYS269F, LYS300H, LYS46H, LYS516F, LYS516H, LYS548F, LYS570H, LYS615F, LYS615H, LYS623H, LYS634H, LYS84F, LYS84H, MET143H, MET153H, MET167H, MET169H, MET266F, MET419F, MET460H, MET575H, MET78H, MET91F, MET91H, PHE189H, PHE242F, PHE285F, PHE298H, PHE417F, PHE417H, PHE426F, PHE443H, PHE454H, PHE576H, PHE637H, PHE638H, PHE68H, PHE73H, PHE82H, PHE87F, PHE96F, PRO105F, PRO130H, PRO172H, PRO195H, PRO216F, PRO216H, PRO220F, PRO234F, PRO279F, PRO281F, PRO287F, PRO291F, PRO296H, PRO301H, PRO333H, PRO335H, PRO359H, PRO371H, PRO415F, PRO415H, PRO43H, PRO457H, PRO468F, PRO486F, PRO526F, PRO526H, PRO560F, PRO563F, PRO580H, PRO589H, PRO646H, PRO94F, SER109F, SER110F, SER138H, SER175H, SER247F, SER251H, SER255F, SER255H, SER256H, SER257H, SER260F, SER260H, SER264F, SER283F, SER288F, SER347F, SER354F, SER452H, SER455H, SER495H, SER500H, SER511H, SER529F, SER529H, SER534F, SER537F, SER541F, SER550F, SER574H, SER578H, SER581H, SER594F, SER598F, SER602F, SER612F, SER621F, SER621H, SER629H, SER643H, SER65H, SER72H, SER83F, THR122H, THR139H, THR148H, THR165H, THR168H, THR171H, THR246F, THR258H, THR265F, THR278F, THR286F, THR336H, THR350F, THR356F, THR356H, THR362H, THR425F, THR430F, THR442H, THR44H, THR458H, THR465F, THR467F, THR494H, THR531F, THR531H, THR536F, THR536H, THR601F, THR606F, THR610F, THR618F, THR618H, THR631H, THR81H, TRP159H, TRP48H, TRP566F, TRP645H, TRP92F, TRP92H, TYR215H, TYR294H, TYR360F, TYR360H, TYR562F, TYR71H, VAL107F, VAL119H, VAL140H, VAL156H, VAL238F, VAL249F, VAL253H, VAL282F, VAL284F, VAL348F, VAL353F, VAL353H, VAL411F, VAL466F, VAL469F, VAL485F, VAL498H, VAL520H, VAL521H, VAL527H, VAL540F, VAL545F, VAL552F, VAL577H, VAL586H, VAL604F, VAL617F, VAL74H
• F-L: ASP197L, LEU196L, THR278F
• F-N: ALA389F, ALA389N, ASN342F, ASN342N, ASN390F, ASN390N, GLN377F, GLN377N, GLN384F, GLN384N, GLU479F, GLU479N, GLY433F, GLY433N, ILE391N, ILE434F, ILE434N, PRO381F, PRO381N, PRO435F, PRO435N, SER379F, SER379N, THR378F, THR378N, THR392F, THR392N, THR432F, THR432N, TYR436F, TYR436N, VAL380F, VAL380N
• G-H: ALA176H, ALA179H, ALA188H, ALA190H, ALA211H, ALA217H, ALA230H, ALA232H, ALA239H, ALA241H, ALA244H, ALA245H, ALA30G, ALA31G, ALA33G, ALA85H, ALA98H, ARG214H, ARG627H, ARG79H, ASN12G, ASN182H, ASN18G, ASN205H, ASN209H, ASN222H, ASN243H, ASN3G, ASN42G, ASN75H, ASN9G, ASP16G, ASP173H, ASP224H, ASP229H, ASP25G, ASP35G, ASP88H, CYS181H, CYS200H, GLN146H, GLN160H, GLN231H, GLN5G, GLN628H, GLN635H, GLN93H, GLN97H, GLU206H, GLU237H, GLU80H, GLY15G, GLY177H, GLY17G, GLY221H, GLY236H, GLY240H, GLY2G, GLY45H, GLY77H, HIS213H, HIS233H, ILE13G, ILE142H, ILE149H, ILE174H, ILE212H, ILE34G, ILE641H, ILE89H, LEU145H, LEU163H, LEU170H, LEU186H, LEU187H, LEU201H, LEU218H, LEU227H, LEU235H, LEU36G, LEU41G, LEU624H, LEU86H, LEU95H, LYS100H, LYS184H, LYS191H, LYS219H, LYS226H, LYS37G, LYS46H, LYS634H, LYS84H, MET153H, MET167H, MET26G, MET78H, MET91H, PHE207H, PHE20G, PHE242H, PHE637H, PHE638H, PHE73H, PHE82H, PHE87H, PRO172H, PRO204H, PRO216H, PRO220H, PRO223H, PRO228H, PRO22G, PRO234H, PRO32G, PRO94H, SER175H, SER178H, SER180H, SER19G, SER247H, SER24G, SER28G, SER72H, SER7G, SER83H, THR10G, THR14G, THR168H, THR171H, THR202H, THR21G, THR225H, THR23G, THR246H, THR27G, THR29G, THR44H, THR631H, THR6G, THR81H, THR99H, TRP183H, TRP92H, TYR11G, TYR203H, TYR208H, TYR215H, VAL210H, VAL238H, VAL253H, VAL40G, VAL4G, VAL74H, VAL8G
• G-K: ASN3K, PRO22G, SER24G, THR21G, THR23G
• G-L: SER24G, THR202L
• H-K: ALA179H, ALA230H, ASN3K, ASP229H, GLN231H, GLN5K, GLY177H, GLY2K, ILE174H, LEU227H, LYS219H, PRO228H, SER178H, SER180H, SER7K, THR6K, VAL4K, VAL8K
• H-L: ALA176H, ALA626H, ARG625H, ASN198L, ASP197L, GLN628H, GLN635H, GLU248H, GLU622H, GLY177H, LEU196L, LEU199L, LEU201L, LEU624H, LEU630H, LYS100L, LYS191L, PRO195L, SER178H, SER247H, SER621H, SER629H, THR202L, THR631H, THR99L, TYR203L, VAL632H
• I-J: ALA176J, ALA179J, ALA188J, ALA190J, ALA211J, ALA217J, ALA230J, ALA232J, ALA239J, ALA241J, ALA244J, ALA245J, ALA30I, ALA31I, ALA33I, ALA85J, ALA98J, ARG214J, ARG627J, ARG79J, ASN12I, ASN182J, ASN18I, ASN205J, ASN209J, ASN222J, ASN243J, ASN3I, ASN42I, ASN75J, ASN9I, ASP16I, ASP173J, ASP224J, ASP229J, ASP25I, ASP35I, ASP88J, CYS181J, CYS200J, GLN146J, GLN160J, GLN231J, GLN5I, GLN628J, GLN635J, GLN93J, GLN97J, GLU206J, GLU237J, GLU80J, GLY15I, GLY177J, GLY17I, GLY221J, GLY236J, GLY240J, GLY2I, GLY45J, GLY77J, HIS213J, HIS233J, ILE13I, ILE142J, ILE149J, ILE174J, ILE212J, ILE34I, ILE641J, ILE89J, LEU145J, LEU163J, LEU170J, LEU186J, LEU187J, LEU201J, LEU218J, LEU227J, LEU235J, LEU36I, LEU41I, LEU624J, LEU86J, LEU95J, LYS100J, LYS184J, LYS191J, LYS219J, LYS226J, LYS37I, LYS46J, LYS634J, LYS84J, MET153J, MET167J, MET26I, MET78J, MET91J, PHE207J, PHE20I, PHE242J, PHE637J, PHE638J, PHE73J, PHE82J, PHE87J, PHE96J, PRO172J, PRO204J, PRO216J, PRO220J, PRO223J, PRO228J, PRO22I, PRO234J, PRO32I, PRO94J, SER175J, SER178J, SER180J, SER19I, SER247J, SER24I, SER28I, SER72J, SER7I, SER83J, THR10I, THR14I, THR168J, THR171J, THR202J, THR21I, THR225J, THR23I, THR246J, THR27I, THR29I, THR44J, THR631J, THR6I, THR81J, THR99J, TRP183J, TRP92J, TYR11I, TYR203J, TYR208J, TYR215J, VAL210J, VAL238J, VAL253J, VAL40I, VAL4I, VAL74J, VAL8I
• I-K: ALA30I, ALA31I, ALA33I, ASN42K, ASP35I, ASP35K, GLY39K, ILE34I, LEU36I, LEU36K, LEU41K, LYS37K, PRO32I, PRO38K, SER28I, THR27I, THR29I, VAL40I, VAL40K
• I-L: ALA123L, ALA262L, ALA267L, ALA62L, ARG147L, ARG609L, ASP25I, ASP35I, GLN146L, GLN261L, GLN70L, GLY268L, GLY39I, GLY611L, ILE142L, ILE263L, ILE63L, LEU259L, LEU36I, LEU608L, LEU613L, LEU61L, LYS37I, LYS46L, MET143L, MET266L, MET26I, PRO38I, SER24I, SER256L, SER257L, SER260L, SER264L, SER612L, THR10I, THR139L, THR23I, THR265L, THR610L, TRP48L, TYR11I, VAL40I
• I-M: ALA30M, ALA31M, ALA33M, ASN42I, ASP35I, ASP35M, GLY39I, ILE34M, LEU36I, LEU36M, LEU41I, LYS37I, PRO32M, PRO38I, SER28M, THR27M, THR29M, VAL40I, VAL40M
• I-N: ALA239N, ALA241N, ALA262N, ALA30I, ALA31I, ALA33I, ALA607N, ARG609N, ASN243N, ASN42I, ASP35I, ASP88N, GLN261N, GLU237N, GLU80N, GLY236N, GLY240N, GLY254N, GLY39I, GLY605N, GLY611N, GLY614N, ILE263N, ILE34I, LEU235N, LEU252N, LEU259N, LEU36I, LEU41I, LEU608N, LEU613N, LYS37I, LYS615N, LYS84N, MET26I, MET91N, PHE242N, PHE87N, PRO22I, PRO32I, PRO38I, SER251N, SER255N, SER256N, SER257N, SER260N, SER264N, SER28I, SER612N, THR258N, THR27I, THR29I, THR606N, THR610N, THR81N, VAL238N, VAL253N, VAL40I
• J-K: ALA239J, ALA241J, ALA262J, ALA30K, ALA31K, ALA33K, ALA607J, ARG609J, ASN243J, ASN42K, ASP35K, ASP88J, GLN261J, GLU237J, GLU80J, GLY236J, GLY240J, GLY254J, GLY39K, GLY605J, GLY611J, GLY614J, ILE263J, ILE34K, LEU235J, LEU252J, LEU259J, LEU36K, LEU41K, LEU608J, LEU613J, LYS37K, LYS615J, LYS84J, MET26K, MET91J, PHE242J, PHE87J, PRO22K, PRO32K, PRO38K, SER251J, SER255J, SER256J, SER257J, SER260J, SER264J, SER28K, SER612J, THR258J, THR27K, THR29K, THR606J, THR610J, THR81J, VAL238J, VAL253J, VAL40K
• J-L: ALA121L, ALA123L, ALA126L, ALA150L, ALA151L, ALA157L, ALA166L, ALA190L, ALA211L, ALA217L, ALA230J, ALA232J, ALA239J, ALA239L, ALA241J, ALA244J, ALA244L, ALA245J, ALA245L, ALA267J, ALA276J, ALA290J, ALA297L, ALA304L, ALA400J, ALA402J, ALA404L, ALA408J, ALA483J, ALA487J, ALA499L, ALA501L, ALA503J, ALA518L, ALA524L, ALA528L, ALA535J, ALA538J, ALA544J, ALA572L, ALA573L, ALA599J, ALA607J, ALA620J, ALA620L, ALA626L, ALA633L, ALA636L, ALA85J, ALA85L, ARG147L, ARG152L, ARG154L, ARG214L, ARG292J, ARG295J, ARG295L, ARG337L, ARG412J, ARG416J, ARG416L, ARG428J, ARG472J, ARG530J, ARG530L, ARG542J, ARG567L, ARG571L, ARG609J, ARG625L, ARG627L, ARG67L, ARG79J, ARG79L, ASN129L, ASN144L, ASN198L, ASN222J, ASN243J, ASN243L, ASN363L, ASN406J, ASN410J, ASN418J, ASN453L, ASN456L, ASN504J, ASN512L, ASN515L, ASN519L, ASN579L, ASN75L, ASN90J, ASP125L, ASP128L, ASP155L, ASP164L, ASP173L, ASP192L, ASP197L, ASP229J, ASP270J, ASP272J, ASP277J, ASP303L, ASP346J, ASP352J, ASP461L, ASP482J, ASP523L, ASP532J, ASP532L, ASP533J, ASP561J, ASP619J, ASP619L, ASP639L, ASP66L, ASP88J, ASP88L, GLN141L, GLN146L, GLN160L, GLN231J, GLN261J, GLN261L, GLN330L, GLN414J, GLN414L, GLN423J, GLN546J, GLN551J, GLN585L, GLN628L, GLN640L, GLN70L, GLN93J, GLN97J, GLU237J, GLU248J, GLU275J, GLU302L, GLU309L, GLU427J, GLU429J, GLU473J, GLU496L, GLU497L, GLU622L, GLU76J, GLU76L, GLU80J, GLU80L, GLY104J, GLY120L, GLY124L, GLY236J, GLY240J, GLY240L, GLY250J, GLY250L, GLY254L, GLY268J, GLY332L, GLY334L, GLY355J, GLY355L, GLY401J, GLY413J, GLY441L, GLY45L, GLY462L, GLY522L, GLY553J, GLY587L, GLY595J, GLY603J, GLY605J, GLY611J, GLY614J, GLY616J, GLY642L, GLY69L, GLY77J, GLY77L, HIS162L, HIS213J, HIS213L, HIS233J, HIS421J, HIS547J, ILE106J, ILE137L, ILE142L, ILE149L, ILE174L, ILE193L, ILE263J, ILE274J, ILE299L, ILE307L, ILE345J, ILE357J, ILE357L, ILE409J, ILE445L, ILE484J, ILE525J, ILE525L, ILE539J, ILE588L, ILE58L, ILE63L, ILE641L, ILE89J, ILE89L, LEU108J, LEU108L, LEU127L, LEU145L, LEU158L, LEU163L, LEU170L, LEU186L, LEU194L, LEU196L, LEU235J, LEU252J, LEU252L, LEU259J, LEU259L, LEU271J, LEU273J, LEU280J, LEU289J, LEU358L, LEU366L, LEU407J, LEU420J, LEU422J, LEU459L, LEU463J, LEU470J, LEU471J, LEU47L, LEU509J, LEU514L, LEU517L, LEU543J, LEU549J, LEU565J, LEU582L, LEU591L, LEU597J, LEU600J, LEU608J, LEU613J, LEU624L, LEU630L, LEU644L, LEU86J, LEU86L, LYS161L, LYS191L, LYS269J, LYS300L, LYS46L, LYS516J, LYS516L, LYS548J, LYS570L, LYS615J, LYS615L, LYS623L, LYS634L, LYS84J, LYS84L, MET143L, MET153L, MET167L, MET169L, MET266J, MET419J, MET460L, MET575L, MET78L, MET91J, MET91L, PHE189L, PHE242J, PHE285J, PHE298L, PHE417J, PHE417L, PHE426J, PHE443L, PHE454L, PHE576L, PHE637L, PHE638L, PHE68L, PHE73L, PHE82L, PHE87J, PHE96J, PRO105J, PRO130L, PRO172L, PRO195L, PRO216J, PRO216L, PRO220J, PRO234J, PRO279J, PRO281J, PRO287J, PRO291J, PRO296L, PRO301L, PRO333L, PRO335L, PRO359L, PRO371L, PRO415J, PRO415L, PRO43L, PRO457L, PRO468J, PRO486J, PRO526J, PRO526L, PRO560J, PRO563J, PRO580L, PRO589L, PRO646L, PRO94J, SER109J, SER110J, SER138L, SER175L, SER247J, SER251L, SER255J, SER255L, SER256L, SER257L, SER260J, SER260L, SER264J, SER283J, SER288J, SER347J, SER354J, SER452L, SER455L, SER495L, SER500L, SER511L, SER529J, SER529L, SER534J, SER537J, SER541J, SER550J, SER574L, SER578L, SER581L, SER594J, SER598J, SER602J, SER612J, SER621J, SER621L, SER629L, SER643L, SER65L, SER72L, SER83J, THR122L, THR139L, THR148L, THR165L, THR168L, THR171L, THR246J, THR258L, THR265J, THR278J, THR286J, THR336L, THR350J, THR356J, THR356L, THR362L, THR425J, THR430J, THR442L, THR44L, THR458L, THR465J, THR467J, THR494L, THR531J, THR531L, THR536J, THR536L, THR601J, THR606J, THR610J, THR618J, THR618L, THR631L, THR81L, TRP159L, TRP48L, TRP566J, TRP645L, TRP92J, TRP92L, TYR215L, TYR294L, TYR360J, TYR360L, TYR562J, TYR71L, VAL107J, VAL119L, VAL140L, VAL156L, VAL238J, VAL249J, VAL253L, VAL282J, VAL284J, VAL348J, VAL353J, VAL353L, VAL411J, VAL466J, VAL469J, VAL485J, VAL498L, VAL520L, VAL521L, VAL527L, VAL540J, VAL545J, VAL552J, VAL577L, VAL586L, VAL604J, VAL617J, VAL74L
• J-M: ALA123J, ALA262J, ALA267J, ALA62J, ARG147J, ARG609J, ASP25M, ASP35M, ASP59J, GLN146J, GLN261J, GLN70J, GLY268J, GLY39M, GLY611J, ILE142J, ILE263J, ILE63J, LEU259J, LEU36M, LEU608J, LEU613J, LEU61J, LYS37M, LYS46J, MET143J, MET266J, MET26M, PRO38M, SER24M, SER256J, SER257J, SER260J, SER264J, SER612J, THR10M, THR139J, THR23M, THR265J, THR610J, TRP48J, TYR11M, VAL40M, VAL51J
• J-N: ALA121J, ALA123J, ALA126J, ALA150J, ALA151J, ALA157J, ALA166J, ALA190J, ALA211J, ALA217J, ALA230N, ALA232N, ALA239J, ALA239N, ALA241N, ALA244J, ALA244N, ALA245J, ALA245N, ALA267N, ALA276N, ALA290N, ALA297J, ALA304J, ALA400N, ALA402N, ALA404J, ALA408N, ALA483N, ALA487N, ALA499J, ALA501J, ALA503N, ALA518J, ALA524J, ALA528J, ALA535N, ALA538N, ALA544N, ALA572J, ALA573J, ALA599N, ALA607N, ALA620J, ALA620N, ALA626J, ALA633J, ALA636J, ALA85J, ALA85N, ARG147J, ARG152J, ARG154J, ARG214J, ARG292N, ARG295J, ARG295N, ARG337J, ARG412N, ARG416J, ARG416N, ARG428N, ARG472N, ARG530J, ARG530N, ARG542N, ARG567J, ARG571J, ARG609N, ARG625J, ARG627J, ARG67J, ARG79J, ARG79N, ASN129J, ASN144J, ASN198J, ASN222N, ASN243J, ASN243N, ASN363J, ASN406N, ASN410N, ASN418N, ASN453J, ASN456J, ASN504N, ASN512J, ASN515J, ASN519J, ASN579J, ASN75J, ASN90N, ASP125J, ASP128J, ASP155J, ASP164J, ASP173J, ASP192J, ASP197J, ASP229N, ASP270N, ASP272N, ASP277N, ASP303J, ASP346N, ASP352N, ASP461J, ASP482N, ASP523J, ASP532J, ASP532N, ASP533N, ASP561N, ASP619J, ASP619N, ASP639J, ASP66J, ASP88J, ASP88N, GLN141J, GLN146J, GLN160J, GLN231N, GLN261J, GLN261N, GLN330J, GLN414J, GLN414N, GLN423N, GLN546N, GLN551N, GLN585J, GLN628J, GLN640J, GLN70J, GLN93N, GLN97N, GLU237N, GLU248N, GLU275N, GLU302J, GLU309J, GLU427N, GLU429N, GLU473N, GLU496J, GLU497J, GLU622J, GLU76J, GLU76N, GLU80J, GLU80N, GLY104N, GLY120J, GLY124J, GLY236N, GLY240J, GLY240N, GLY250J, GLY250N, GLY254J, GLY268N, GLY332J, GLY334J, GLY355J, GLY355N, GLY401N, GLY413N, GLY441J, GLY45J, GLY462J, GLY522J, GLY553N, GLY587J, GLY595N, GLY603N, GLY605N, GLY611N, GLY614N, GLY616N, GLY642J, GLY69J, GLY77J, GLY77N, HIS162J, HIS213J, HIS213N, HIS233N, HIS421N, HIS547N, ILE106N, ILE137J, ILE142J, ILE149J, ILE174J, ILE193J, ILE263N, ILE274N, ILE299J, ILE307J, ILE345N, ILE357J, ILE357N, ILE409N, ILE445J, ILE484N, ILE525J, ILE525N, ILE539N, ILE588J, ILE58J, ILE63J, ILE641J, ILE89J, ILE89N, LEU108J, LEU108N, LEU127J, LEU145J, LEU158J, LEU163J, LEU170J, LEU186J, LEU194J, LEU196J, LEU235N, LEU252J, LEU252N, LEU259J, LEU259N, LEU271N, LEU273N, LEU280N, LEU289N, LEU358J, LEU366J, LEU407N, LEU420N, LEU422N, LEU459J, LEU463N, LEU470N, LEU471N, LEU47J, LEU509N, LEU514J, LEU517J, LEU543N, LEU549N, LEU565N, LEU582J, LEU591J, LEU597N, LEU600N, LEU608N, LEU613N, LEU624J, LEU630J, LEU644J, LEU86J, LEU86N, LYS161J, LYS191J, LYS269N, LYS300J, LYS46J, LYS516J, LYS516N, LYS548N, LYS570J, LYS615J, LYS615N, LYS623J, LYS634J, LYS84J, LYS84N, MET143J, MET153J, MET167J, MET169J, MET266N, MET419N, MET460J, MET575J, MET78J, MET91J, MET91N, PHE189J, PHE242N, PHE285N, PHE298J, PHE417J, PHE417N, PHE426N, PHE443J, PHE454J, PHE576J, PHE637J, PHE638J, PHE68J, PHE73J, PHE82J, PHE87N, PHE96N, PRO105N, PRO130J, PRO172J, PRO195J, PRO216J, PRO216N, PRO220N, PRO234N, PRO279N, PRO281N, PRO287N, PRO291N, PRO296J, PRO301J, PRO333J, PRO335J, PRO359J, PRO371J, PRO415J, PRO415N, PRO43J, PRO457J, PRO468N, PRO486N, PRO526J, PRO526N, PRO560N, PRO563N, PRO580J, PRO589J, PRO646J, PRO94N, SER109N, SER110N, SER138J, SER175J, SER247N, SER251J, SER255J, SER255N, SER256J, SER257J, SER260J, SER260N, SER264N, SER283N, SER288N, SER347N, SER354N, SER452J, SER455J, SER495J, SER500J, SER511J, SER529J, SER529N, SER534N, SER537N, SER541N, SER550N, SER574J, SER578J, SER581J, SER594N, SER598N, SER602N, SER612N, SER621J, SER621N, SER629J, SER643J, SER65J, SER72J, SER83N, THR122J, THR139J, THR148J, THR165J, THR168J, THR171J, THR246N, THR258J, THR265N, THR278N, THR286N, THR336J, THR350N, THR356J, THR356N, THR362J, THR425N, THR430N, THR442J, THR44J, THR458J, THR465N, THR467N, THR494J, THR531J, THR531N, THR536J, THR536N, THR601N, THR606N, THR610N, THR618J, THR618N, THR631J, THR81J, TRP159J, TRP48J, TRP566N, TRP645J, TRP92J, TRP92N, TYR215J, TYR294J, TYR360J, TYR360N, TYR562N, TYR71J, VAL107N, VAL119J, VAL140J, VAL156J, VAL238N, VAL249N, VAL253J, VAL282N, VAL284N, VAL348N, VAL353J, VAL353N, VAL411N, VAL466N, VAL469N, VAL485N, VAL498J, VAL520J, VAL521J, VAL527J, VAL540N, VAL545N, VAL552N, VAL577J, VAL586J, VAL604N, VAL617N, VAL74J
• J-R: ASP197R, LEU196R, THR278J
• J-T: ALA389J, ALA389T, ASN342J, ASN342T, ASN390J, ASN390T, GLN377J, GLN377T, GLN384J, GLN384T, GLU479J, GLU479T, GLY433J, GLY433T, ILE434J, ILE434T, PRO381J, PRO381T, PRO435J, PRO435T, SER379J, SER379T, THR378J, THR378T, THR392J, THR392T, THR432J, THR432T, TYR436J, TYR436T, VAL380J, VAL380T
• J-V: ARG67J, ASP301V
• K-L: ALA176L, ALA179L, ALA188L, ALA190L, ALA211L, ALA217L, ALA230L, ALA232L, ALA239L, ALA241L, ALA244L, ALA245L, ALA30K, ALA31K, ALA33K, ALA85L, ALA98L, ARG214L, ARG627L, ARG79L, ASN12K, ASN182L, ASN18K, ASN205L, ASN209L, ASN222L, ASN243L, ASN3K, ASN42K, ASN75L, ASN9K, ASP16K, ASP173L, ASP224L, ASP229L, ASP25K, ASP35K, ASP88L, CYS181L, CYS200L, GLN146L, GLN160L, GLN231L, GLN5K, GLN628L, GLN635L, GLN93L, GLN97L, GLU206L, GLU237L, GLU80L, GLY15K, GLY177L, GLY17K, GLY221L, GLY236L, GLY240L, GLY2K, GLY45L, GLY77L, HIS213L, HIS233L, ILE13K, ILE142L, ILE149L, ILE174L, ILE212L, ILE34K, ILE641L, ILE89L, LEU145L, LEU163L, LEU170L, LEU186L, LEU187L, LEU201L, LEU218L, LEU227L, LEU235L, LEU36K, LEU41K, LEU624L, LEU86L, LEU95L, LYS100L, LYS184L, LYS191L, LYS219L, LYS226L, LYS37K, LYS46L, LYS634L, LYS84L, MET153L, MET167L, MET26K, MET78L, MET91L, PHE207L, PHE20K, PHE242L, PHE637L, PHE638L, PHE73L, PHE82L, PHE87L, PHE96L, PRO172L, PRO204L, PRO216L, PRO220L, PRO223L, PRO228L, PRO22K, PRO234L, PRO32K, PRO94L, SER175L, SER178L, SER180L, SER19K, SER247L, SER24K, SER28K, SER72L, SER7K, SER83L, THR10K, THR14K, THR168L, THR171L, THR202L, THR21K, THR225L, THR23K, THR246L, THR27K, THR29K, THR44L, THR631L, THR6K, THR81L, THR99L, TRP183L, TRP92L, TYR11K, TYR203L, TYR208L, TYR215L, VAL210L, VAL238L, VAL253L, VAL40K, VAL4K, VAL74L, VAL8K
• K-M: ALA30K, ALA31K, ALA33K, ASN42M, ASP35K, ASP35M, GLY39M, ILE34K, LEU36K, LEU36M, LEU41M, LYS37M, PRO32K, PRO38M, SER28K, THR27K, THR29K, VAL40K, VAL40M
• K-N: ALA123N, ALA262N, ALA267N, ALA62N, ARG147N, ARG609N, ASP25K, ASP35K, GLN146N, GLN261N, GLN70N, GLY268N, GLY39K, GLY611N, ILE142N, ILE263N, ILE63N, LEU259N, LEU36K, LEU608N, LEU613N, LEU61N, LYS37K, LYS46N, MET143N, MET266N, MET26K, PRO38K, SER24K, SER256N, SER257N, SER260N, SER264N, SER612N, THR10K, THR139N, THR23K, THR265N, THR610N, TRP48N, TYR11K, VAL40K
• K-Q: ASN3Q, ASP25K, GLN5Q, PRO22K, SER24K, THR21K, THR23K, VAL4Q
• K-R: SER24K, THR202R
• L-M: ALA239L, ALA241L, ALA262L, ALA30M, ALA31M, ALA33M, ALA607L, ARG609L, ASN243L, ASN42M, ASP35M, ASP88L, GLN261L, GLU237L, GLU80L, GLY236L, GLY240L, GLY254L, GLY39M, GLY605L, GLY611L, GLY614L, ILE263L, ILE34M, LEU235L, LEU252L, LEU259L, LEU36M, LEU41M, LEU608L, LEU613L, LYS37M, LYS615L, LYS84L, MET26M, MET91L, PHE242L, PHE87L, PRO22M, PRO32M, PRO38M, SER251L, SER255L, SER256L, SER257L, SER260L, SER264L, SER28M, SER612L, THR258L, THR27M, THR29M, THR606L, THR610L, THR81L, VAL238L, VAL253L, VAL40M
• L-N: ALA121N, ALA123N, ALA126N, ALA150N, ALA151N, ALA157N, ALA166N, ALA190N, ALA211N, ALA217N, ALA230L, ALA232L, ALA239L, ALA239N, ALA241L, ALA244L, ALA244N, ALA245L, ALA245N, ALA267L, ALA276L, ALA290L, ALA297N, ALA304N, ALA400L, ALA402L, ALA404N, ALA408L, ALA483L, ALA487L, ALA499N, ALA501N, ALA503L, ALA518N, ALA524N, ALA528N, ALA535L, ALA538L, ALA544L, ALA572N, ALA573N, ALA599L, ALA607L, ALA620L, ALA620N, ALA626N, ALA633N, ALA636N, ALA85L, ALA85N, ARG147N, ARG152N, ARG154N, ARG214N, ARG292L, ARG295L, ARG295N, ARG337N, ARG412L, ARG416L, ARG416N, ARG428L, ARG472L, ARG530L, ARG530N, ARG542L, ARG567N, ARG571N, ARG609L, ARG625N, ARG627N, ARG67N, ARG79L, ARG79N, ASN129N, ASN144N, ASN198N, ASN222L, ASN243L, ASN243N, ASN363N, ASN406L, ASN410L, ASN418L, ASN453N, ASN456N, ASN504L, ASN512N, ASN515N, ASN519N, ASN579N, ASN75N, ASN90L, ASP125N, ASP128N, ASP155N, ASP164N, ASP173N, ASP192N, ASP197N, ASP229L, ASP270L, ASP272L, ASP277L, ASP303N, ASP346L, ASP352L, ASP461N, ASP482L, ASP523N, ASP532L, ASP532N, ASP533L, ASP561L, ASP619L, ASP619N, ASP639N, ASP66N, ASP88L, ASP88N, GLN141N, GLN146N, GLN160N, GLN231L, GLN261L, GLN261N, GLN330N, GLN414L, GLN414N, GLN423L, GLN546L, GLN551L, GLN585N, GLN628N, GLN640N, GLN70N, GLN93L, GLN97L, GLU237L, GLU248L, GLU275L, GLU302N, GLU309N, GLU427L, GLU429L, GLU473L, GLU496N, GLU497N, GLU622N, GLU76L, GLU76N, GLU80L, GLU80N, GLY104L, GLY120N, GLY124N, GLY236L, GLY240L, GLY240N, GLY250L, GLY250N, GLY254N, GLY268L, GLY332N, GLY334N, GLY355L, GLY355N, GLY401L, GLY413L, GLY441N, GLY45N, GLY462N, GLY522N, GLY553L, GLY587N, GLY595L, GLY603L, GLY605L, GLY611L, GLY614L, GLY616L, GLY642N, GLY69N, GLY77L, GLY77N, HIS162N, HIS213L, HIS213N, HIS233L, HIS421L, HIS547L, ILE106L, ILE137N, ILE142N, ILE149N, ILE174N, ILE193N, ILE263L, ILE274L, ILE299N, ILE307N, ILE345L, ILE357L, ILE357N, ILE409L, ILE445N, ILE484L, ILE525L, ILE525N, ILE539L, ILE588N, ILE58N, ILE63N, ILE641N, ILE89L, ILE89N, LEU108L, LEU108N, LEU127N, LEU145N, LEU158N, LEU163N, LEU170N, LEU186N, LEU194N, LEU196N, LEU235L, LEU252L, LEU252N, LEU259L, LEU259N, LEU271L, LEU273L, LEU280L, LEU289L, LEU358N, LEU366N, LEU407L, LEU420L, LEU422L, LEU459N, LEU463L, LEU470L, LEU471L, LEU47N, LEU509L, LEU514N, LEU517N, LEU543L, LEU549L, LEU565L, LEU582N, LEU591N, LEU597L, LEU600L, LEU608L, LEU613L, LEU624N, LEU630N, LEU644N, LEU86L, LEU86N, LYS161N, LYS191N, LYS269L, LYS300N, LYS46N, LYS516L, LYS516N, LYS548L, LYS570N, LYS615L, LYS615N, LYS623N, LYS634N, LYS84L, LYS84N, MET143N, MET153N, MET167N, MET169N, MET266L, MET419L, MET460N, MET575N, MET78N, MET91L, MET91N, PHE189N, PHE242L, PHE285L, PHE298N, PHE417L, PHE417N, PHE426L, PHE443N, PHE454N, PHE576N, PHE637N, PHE638N, PHE68N, PHE73N, PHE82N, PHE87L, PHE96L, PRO105L, PRO130N, PRO172N, PRO195N, PRO216L, PRO216N, PRO220L, PRO234L, PRO279L, PRO281L, PRO287L, PRO291L, PRO296N, PRO301N, PRO333N, PRO335N, PRO359N, PRO371N, PRO415L, PRO415N, PRO43N, PRO457N, PRO468L, PRO486L, PRO526L, PRO526N, PRO560L, PRO563L, PRO580N, PRO589N, PRO646N, PRO94L, SER109L, SER110L, SER138N, SER175N, SER247L, SER251N, SER255L, SER255N, SER256N, SER257N, SER260L, SER260N, SER264L, SER283L, SER288L, SER347L, SER354L, SER452N, SER455N, SER495N, SER500N, SER511N, SER529N, SER534L, SER537L, SER541L, SER550L, SER574N, SER578N, SER581N, SER594L, SER598L, SER602L, SER612L, SER621L, SER621N, SER629N, SER643N, SER65N, SER72N, SER83L, THR122N, THR139N, THR148N, THR165N, THR168N, THR171N, THR246L, THR258N, THR265L, THR278L, THR286L, THR336N, THR350L, THR356L, THR356N, THR362N, THR425L, THR430L, THR442N, THR44N, THR458N, THR465L, THR467L, THR494N, THR531L, THR531N, THR536L, THR536N, THR601L, THR606L, THR610L, THR618L, THR618N, THR631N, THR81N, TRP159N, TRP48N, TRP566L, TRP645N, TRP92L, TRP92N, TYR215N, TYR294N, TYR360L, TYR360N, TYR562L, TYR71N, VAL107L, VAL119N, VAL140N, VAL156N, VAL238L, VAL249L, VAL253N, VAL282L, VAL284L, VAL348L, VAL353L, VAL353N, VAL411L, VAL466L, VAL469L, VAL485L, VAL498N, VAL520N, VAL521N, VAL527N, VAL540L, VAL545L, VAL552L, VAL577N, VAL586N, VAL604L, VAL617L, VAL74N
• L-Q: ALA179L, ALA230L, ASN12Q, ASN3Q, ASP229L, GLN231L, GLN5Q, GLN635L, GLY177L, GLY2Q, ILE174L, LEU227L, LYS219L, PRO228L, SER178L, SER180L, SER7Q, THR6Q, VAL4Q, VAL8Q
• L-R: ALA176L, ALA179L, ALA626L, ALA633L, ARG625L, ARG627L, ASN198R, ASP192R, ASP197R, CYS200R, GLN628L, GLN635L, GLU248L, GLU622L, GLY177L, LEU194R, LEU196R, LEU199R, LEU201R, LEU624L, LEU630L, LYS100R, LYS191R, PRO195R, PRO204R, SER178L, SER180L, SER247L, SER621L, SER629L, THR202R, THR631L, THR99R, TYR203R, VAL632L
• M-N: ALA176N, ALA179N, ALA188N, ALA190N, ALA211N, ALA217N, ALA230N, ALA232N, ALA239N, ALA241N, ALA244N, ALA245N, ALA30M, ALA31M, ALA33M, ALA85N, ALA98N, ARG214N, ARG627N, ARG79N, ASN12M, ASN182N, ASN18M, ASN205N, ASN209N, ASN222N, ASN243N, ASN3M, ASN42M, ASN75N, ASN9M, ASP16M, ASP173N, ASP224N, ASP229N, ASP25M, ASP35M, ASP88N, CYS181N, CYS200N, GLN146N, GLN160N, GLN231N, GLN5M, GLN628N, GLN635N, GLN93N, GLN97N, GLU206N, GLU237N, GLU80N, GLY15M, GLY177N, GLY17M, GLY221N, GLY236N, GLY240N, GLY2M, GLY45N, GLY77N, HIS213N, HIS233N, ILE13M, ILE142N, ILE149N, ILE174N, ILE212N, ILE34M, ILE641N, ILE89N, LEU145N, LEU163N, LEU170N, LEU186N, LEU187N, LEU201N, LEU218N, LEU227N, LEU235N, LEU36M, LEU41M, LEU624N, LEU86N, LEU95N, LYS100N, LYS184N, LYS191N, LYS219N, LYS226N, LYS37M, LYS46N, LYS634N, LYS84N, MET153N, MET167N, MET26M, MET78N, MET91N, PHE207N, PHE20M, PHE242N, PHE637N, PHE638N, PHE73N, PHE82N, PHE87N, PRO172N, PRO204N, PRO216N, PRO220N, PRO223N, PRO228N, PRO22M, PRO234N, PRO32M, PRO94N, SER175N, SER178N, SER180N, SER19M, SER247N, SER24M, SER28M, SER72N, SER7M, SER83N, THR10M, THR14M, THR168N, THR171N, THR202N, THR21M, THR225N, THR23M, THR246N, THR27M, THR29M, THR44N, THR631N, THR6M, THR81N, THR99N, TRP183N, TRP92N, TYR11M, TYR203N, TYR208N, TYR215N, VAL210N, VAL238N, VAL253N, VAL40M, VAL4M, VAL74N, VAL8M
• M-O: ASN3M, THR21O
• M-P: ALA179P, ALA230P, ASN3M, GLN231P, GLN5M, GLY177P, SER178P, SER180P, THR6M, VAL4M
• M-R: ARG67R, SER7M, THR6M
• N-P: ARG625P, ASN198N, ASP197N, GLN628P, GLU248P, GLY177P, LEU196N, LEU199N, LEU201N, LEU624P, LYS100N, SER247P, SER621P, SER629P, THR202N, THR99N, TYR203N, VAL632P
• N-Q: ARG147N, ARG67N, ASN144N, GLN5Q, MET143N, PHE68N, SER7Q, THR6Q, VAL140N, VAL8Q
• N-R: ALA150N, ALA150R, ALA151N, ALA151R, ALA98N, ALA98R, ARG147N, ARG147R, ARG152N, ARG152R, ARG154N, ARG154R, ASN144N, ASN144R, ASP155N, ASP155R, CYS103N, CYS103R, GLN141N, GLN146N, GLN146R, GLN97N, GLN97R, GLU206R, GLY102N, GLY102R, GLY104N, GLY104R, ILE106N, ILE149N, ILE149R, LEU145N, LEU145R, LYS100N, LYS100R, MET143N, MET143R, PHE111N, PHE111R, PHE96N, PHE96R, THR101N, THR101R, THR148N, THR148R, THR202R, THR99N, THR99R, TRP159N, TRP159R, TYR203N, TYR203R, VAL140N
• O-P: ALA176P, ALA179P, ALA188P, ALA190P, ALA211P, ALA217P, ALA230P, ALA232P, ALA239P, ALA241P, ALA244P, ALA245P, ALA30O, ALA31O, ALA33O, ALA85P, ALA98P, ARG214P, ARG627P, ARG79P, ASN12O, ASN182P, ASN18O, ASN205P, ASN209P, ASN222P, ASN243P, ASN3O, ASN42O, ASN75P, ASN9O, ASP16O, ASP173P, ASP224P, ASP229P, ASP25O, ASP35O, ASP88P, CYS181P, CYS200P, GLN146P, GLN160P, GLN231P, GLN5O, GLN628P, GLN635P, GLN93P, GLN97P, GLU206P, GLU237P, GLU80P, GLY15O, GLY177P, GLY17O, GLY221P, GLY236P, GLY240P, GLY2O, GLY45P, GLY77P, HIS213P, HIS233P, ILE13O, ILE142P, ILE149P, ILE174P, ILE212P, ILE34O, ILE641P, ILE89P, LEU145P, LEU163P, LEU170P, LEU186P, LEU187P, LEU201P, LEU218P, LEU227P, LEU235P, LEU36O, LEU41O, LEU624P, LEU86P, LEU95P, LYS100P, LYS184P, LYS191P, LYS219P, LYS226P, LYS37O, LYS46P, LYS634P, LYS84P, MET153P, MET167P, MET26O, MET78P, MET91P, PHE207P, PHE20O, PHE242P, PHE637P, PHE638P, PHE73P, PHE82P, PHE87P, PHE96P, PRO172P, PRO204P, PRO216P, PRO220P, PRO223P, PRO228P, PRO22O, PRO234P, PRO32O, PRO94P, SER175P, SER178P, SER180P, SER19O, SER247P, SER24O, SER28O, SER72P, SER7O, SER83P, THR10O, THR14O, THR168P, THR171P, THR202P, THR21O, THR225P, THR23O, THR246P, THR27O, THR29O, THR44P, THR631P, THR6O, THR81P, THR99P, TRP183P, TRP92P, TYR11O, TYR203P, TYR208P, TYR215P, VAL210P, VAL238P, VAL253P, VAL40O, VAL4O, VAL74P, VAL8O
• O-Q: ALA30O, ALA31O, ALA33O, ASN42Q, ASP35O, ASP35Q, GLY39Q, ILE34O, LEU36O, LEU36Q, LEU41Q, LYS37Q, PRO32O, PRO38Q, SER28O, THR27O, THR29O, VAL40O, VAL40Q
• O-R: ALA123R, ALA262R, ALA267R, ALA62R, ARG147R, ARG609R, ASP25O, ASP35O, GLN146R, GLN261R, GLN70R, GLY268R, GLY39O, GLY611R, ILE142R, ILE263R, ILE63R, LEU259R, LEU36O, LEU608R, LEU613R, LEU61R, LYS37O, LYS46R, MET143R, MET266R, MET26O, PRO38O, SER24O, SER256R, SER257R, SER260R, SER264R, SER612R, THR10O, THR139R, THR23O, THR265R, THR610R, TRP48R, TYR11O, VAL40O
• O-S: ALA30S, ALA31S, ALA33S, ASN42O, ASP35O, ASP35S, GLY39O, ILE34S, LEU36O, LEU36S, LEU41O, LYS37O, PRO32S, PRO38O, SER28S, THR27S, THR29S, VAL40O, VAL40S
• O-T: ALA239T, ALA241T, ALA262T, ALA30O, ALA31O, ALA33O, ALA607T, ARG609T, ASN243T, ASN42O, ASP35O, ASP88T, GLN261T, GLU237T, GLU80T, GLY236T, GLY240T, GLY254T, GLY39O, GLY605T, GLY611T, GLY614T, ILE263T, ILE34O, LEU235T, LEU252T, LEU259T, LEU36O, LEU41O, LEU608T, LEU613T, LYS37O, LYS615T, LYS84T, MET26O, MET91T, PHE242T, PHE87T, PRO22O, PRO32O, PRO38O, SER251T, SER255T, SER256T, SER257T, SER260T, SER264T, SER28O, SER612T, THR258T, THR27O, THR29O, THR606T, THR610T, THR81T, VAL238T, VAL253T, VAL40O
• P-Q: ALA239P, ALA241P, ALA262P, ALA30Q, ALA31Q, ALA33Q, ALA607P, ARG609P, ASN243P, ASN42Q, ASP35Q, ASP88P, GLN261P, GLU237P, GLU80P, GLY236P, GLY240P, GLY254P, GLY39Q, GLY605P, GLY611P, GLY614P, ILE263P, ILE34Q, LEU235P, LEU252P, LEU259P, LEU36Q, LEU41Q, LEU608P, LEU613P, LYS37Q, LYS615P, LYS84P, MET26Q, MET91P, PHE242P, PHE87P, PRO22Q, PRO32Q, PRO38Q, SER251P, SER255P, SER256P, SER257P, SER260P, SER264P, SER28Q, SER612P, THR258P, THR27Q, THR29Q, THR606P, THR610P, THR81P, VAL238P, VAL253P, VAL40Q
• P-R: ALA121R, ALA123R, ALA126R, ALA150R, ALA151R, ALA157R, ALA166R, ALA190R, ALA211R, ALA217R, ALA230P, ALA232P, ALA239P, ALA239R, ALA241P, ALA244P, ALA244R, ALA245P, ALA245R, ALA267P, ALA276P, ALA290P, ALA297R, ALA304R, ALA400P, ALA402P, ALA404R, ALA408P, ALA483P, ALA487P, ALA499R, ALA501R, ALA503P, ALA518R, ALA524R, ALA528R, ALA535P, ALA538P, ALA544P, ALA572R, ALA573R, ALA599P, ALA607P, ALA620P, ALA620R, ALA626R, ALA633R, ALA636R, ALA85P, ALA85R, ARG147R, ARG152R, ARG154R, ARG214R, ARG292P, ARG295P, ARG295R, ARG337R, ARG412P, ARG416P, ARG416R, ARG428P, ARG472P, ARG530P, ARG530R, ARG542P, ARG567R, ARG571R, ARG609P, ARG625R, ARG627R, ARG67R, ARG79P, ARG79R, ASN129R, ASN144R, ASN198R, ASN222P, ASN243P, ASN243R, ASN363R, ASN406P, ASN410P, ASN418P, ASN453R, ASN456R, ASN504P, ASN512R, ASN515R, ASN519R, ASN579R, ASN75R, ASN90P, ASP125R, ASP128R, ASP155R, ASP164R, ASP173R, ASP192R, ASP197R, ASP229P, ASP270P, ASP272P, ASP277P, ASP303R, ASP346P, ASP352P, ASP461R, ASP482P, ASP523R, ASP532P, ASP532R, ASP533P, ASP561P, ASP619P, ASP619R, ASP639R, ASP66R, ASP88P, ASP88R, GLN141R, GLN146R, GLN160R, GLN231P, GLN261P, GLN261R, GLN330R, GLN414P, GLN414R, GLN423P, GLN546P, GLN551P, GLN585R, GLN628R, GLN640R, GLN70R, GLN93P, GLN97P, GLU237P, GLU248P, GLU275P, GLU302R, GLU309R, GLU427P, GLU429P, GLU473P, GLU496R, GLU497R, GLU622R, GLU76P, GLU76R, GLU80P, GLU80R, GLY104P, GLY120R, GLY124R, GLY236P, GLY240P, GLY240R, GLY250P, GLY250R, GLY254R, GLY268P, GLY332R, GLY334R, GLY355P, GLY355R, GLY401P, GLY413P, GLY441R, GLY45R, GLY462R, GLY522R, GLY553P, GLY587R, GLY595P, GLY603P, GLY605P, GLY611P, GLY614P, GLY616P, GLY642R, GLY69R, GLY77P, GLY77R, HIS162R, HIS213P, HIS213R, HIS233P, HIS421P, HIS547P, ILE106P, ILE137R, ILE142R, ILE149R, ILE174R, ILE193R, ILE263P, ILE274P, ILE299R, ILE307R, ILE345P, ILE357P, ILE357R, ILE409P, ILE445R, ILE484P, ILE525P, ILE525R, ILE539P, ILE588R, ILE58R, ILE63R, ILE641R, ILE89P, ILE89R, LEU108P, LEU108R, LEU127R, LEU145R, LEU158R, LEU163R, LEU170R, LEU186R, LEU194R, LEU196R, LEU235P, LEU252P, LEU252R, LEU259P, LEU259R, LEU271P, LEU273P, LEU280P, LEU289P, LEU358R, LEU366R, LEU407P, LEU420P, LEU422P, LEU459R, LEU463P, LEU470P, LEU471P, LEU47R, LEU509P, LEU514R, LEU517R, LEU543P, LEU549P, LEU565P, LEU582R, LEU591R, LEU597P, LEU600P, LEU608P, LEU613P, LEU624R, LEU630R, LEU644R, LEU86P, LEU86R, LYS161R, LYS191R, LYS269P, LYS300R, LYS46R, LYS516P, LYS516R, LYS548P, LYS570R, LYS615P, LYS615R, LYS623R, LYS634R, LYS84P, LYS84R, MET143R, MET153R, MET167R, MET169R, MET266P, MET419P, MET460R, MET575R, MET78R, MET91P, MET91R, PHE189R, PHE242P, PHE285P, PHE298R, PHE417P, PHE417R, PHE426P, PHE443R, PHE454R, PHE576R, PHE637R, PHE638R, PHE68R, PHE73R, PHE82R, PHE87P, PHE96P, PRO105P, PRO130R, PRO172R, PRO195R, PRO216P, PRO216R, PRO220P, PRO234P, PRO279P, PRO281P, PRO287P, PRO291P, PRO296R, PRO301R, PRO333R, PRO335R, PRO359R, PRO371R, PRO415P, PRO415R, PRO43R, PRO457R, PRO468P, PRO486P, PRO526P, PRO526R, PRO560P, PRO563P, PRO580R, PRO589R, PRO646R, PRO94P, SER109P, SER110P, SER138R, SER175R, SER247P, SER251R, SER255P, SER255R, SER256R, SER257R, SER260P, SER260R, SER264P, SER283P, SER288P, SER347P, SER354P, SER452R, SER455R, SER495R, SER500R, SER511R, SER529P, SER529R, SER534P, SER537P, SER541P, SER550P, SER574R, SER578R, SER581R, SER594P, SER598P, SER602P, SER612P, SER621P, SER621R, SER629R, SER643R, SER65R, SER72R, SER83P, THR122R, THR139R, THR148R, THR165R, THR168R, THR171R, THR246P, THR258R, THR265P, THR278P, THR286P, THR336R, THR350P, THR356P, THR356R, THR362R, THR425P, THR430P, THR442R, THR44R, THR458R, THR465P, THR467P, THR494R, THR531P, THR531R, THR536P, THR601P, THR606P, THR610P, THR618P, THR618R, THR631R, THR81R, TRP159R, TRP48R, TRP566P, TRP645R, TRP92P, TRP92R, TYR215R, TYR294R, TYR360P, TYR360R, TYR562P, TYR71R, VAL107P, VAL119R, VAL140R, VAL156R, VAL238P, VAL249P, VAL253R, VAL282P, VAL284P, VAL348P, VAL353P, VAL353R, VAL411P, VAL466P, VAL469P, VAL485P, VAL498R, VAL520R, VAL521R, VAL527R, VAL540P, VAL545P, VAL552P, VAL577R, VAL586R, VAL604P, VAL617P, VAL74R
• P-S: ALA123P, ALA262P, ALA267P, ALA62P, ARG147P, ARG609P, ASP25S, ASP35S, GLN146P, GLN261P, GLN70P, GLY268P, GLY39S, GLY611P, ILE142P, ILE263P, ILE63P, LEU259P, LEU36S, LEU608P, LEU613P, LEU61P, LYS37S, LYS46P, MET143P, MET266P, MET26S, PRO38S, SER24S, SER256P, SER257P, SER260P, SER264P, SER612P, THR10S, THR139P, THR23S, THR265P, THR610P, TRP48P, TYR11S, VAL40S
• P-T: ALA121P, ALA123P, ALA126P, ALA150P, ALA151P, ALA157P, ALA166P, ALA190P, ALA211P, ALA217P, ALA230T, ALA232T, ALA239P, ALA239T, ALA241T, ALA244P, ALA244T, ALA245P, ALA245T, ALA267T, ALA276T, ALA290T, ALA297P, ALA304P, ALA400T, ALA402T, ALA404P, ALA408T, ALA483T, ALA487T, ALA499P, ALA501P, ALA503T, ALA518P, ALA524P, ALA528P, ALA535T, ALA538T, ALA544T, ALA572P, ALA573P, ALA599T, ALA607T, ALA620P, ALA620T, ALA626P, ALA633P, ALA636P, ALA85P, ALA85T, ARG147P, ARG152P, ARG154P, ARG214P, ARG292T, ARG295P, ARG295T, ARG337P, ARG412T, ARG416P, ARG416T, ARG428T, ARG472T, ARG530P, ARG530T, ARG542T, ARG567P, ARG571P, ARG609T, ARG625P, ARG627P, ARG67P, ARG79P, ARG79T, ASN129P, ASN144P, ASN198P, ASN222T, ASN243P, ASN243T, ASN363P, ASN406T, ASN410T, ASN418T, ASN453P, ASN456P, ASN504T, ASN512P, ASN515P, ASN519P, ASN579P, ASN75P, ASN90T, ASP125P, ASP128P, ASP155P, ASP164P, ASP173P, ASP192P, ASP197P, ASP229T, ASP270T, ASP272T, ASP277T, ASP303P, ASP346T, ASP352T, ASP461P, ASP482T, ASP523P, ASP532P, ASP532T, ASP533T, ASP561T, ASP619P, ASP619T, ASP639P, ASP66P, ASP88P, ASP88T, GLN141P, GLN146P, GLN160P, GLN231T, GLN261P, GLN261T, GLN330P, GLN414P, GLN414T, GLN423T, GLN546T, GLN551T, GLN585P, GLN628P, GLN640P, GLN70P, GLN93T, GLN97T, GLU237T, GLU248T, GLU275T, GLU302P, GLU309P, GLU427T, GLU429T, GLU473T, GLU496P, GLU497P, GLU622P, GLU76P, GLU76T, GLU80P, GLU80T, GLY104T, GLY120P, GLY124P, GLY236T, GLY240P, GLY240T, GLY250P, GLY250T, GLY254P, GLY268T, GLY332P, GLY334P, GLY355P, GLY355T, GLY401T, GLY413T, GLY441P, GLY45P, GLY462P, GLY522P, GLY553T, GLY587P, GLY595T, GLY603T, GLY605T, GLY611T, GLY614T, GLY616T, GLY642P, GLY69P, GLY77P, GLY77T, HIS162P, HIS213P, HIS213T, HIS233T, HIS421T, HIS547T, ILE106T, ILE137P, ILE142P, ILE149P, ILE174P, ILE193P, ILE263T, ILE274T, ILE299P, ILE307P, ILE345T, ILE357P, ILE357T, ILE409T, ILE445P, ILE484T, ILE525P, ILE525T, ILE539T, ILE588P, ILE58P, ILE63P, ILE641P, ILE89P, ILE89T, LEU108P, LEU108T, LEU127P, LEU145P, LEU158P, LEU163P, LEU170P, LEU186P, LEU194P, LEU196P, LEU235T, LEU252P, LEU252T, LEU259P, LEU259T, LEU271T, LEU273T, LEU280T, LEU289T, LEU358P, LEU366P, LEU407T, LEU420T, LEU422T, LEU459P, LEU463T, LEU470T, LEU471T, LEU47P, LEU509T, LEU514P, LEU517P, LEU543T, LEU549T, LEU565T, LEU582P, LEU591P, LEU597T, LEU600T, LEU608T, LEU613T, LEU624P, LEU630P, LEU644P, LEU86P, LEU86T, LYS161P, LYS191P, LYS269T, LYS300P, LYS46P, LYS516P, LYS516T, LYS548T, LYS570P, LYS570T, LYS615P, LYS615T, LYS623P, LYS634P, LYS84P, LYS84T, MET143P, MET153P, MET167P, MET169P, MET266T, MET419T, MET460P, MET575P, MET78P, MET91P, MET91T, PHE189P, PHE242T, PHE285T, PHE298P, PHE417P, PHE417T, PHE426T, PHE443P, PHE454P, PHE576P, PHE637P, PHE638P, PHE68P, PHE73P, PHE82P, PHE87T, PHE96T, PRO105T, PRO130P, PRO172P, PRO195P, PRO216P, PRO216T, PRO220T, PRO234T, PRO279T, PRO281T, PRO287T, PRO291T, PRO296P, PRO301P, PRO333P, PRO335P, PRO359P, PRO371P, PRO415P, PRO415T, PRO43P, PRO457P, PRO468T, PRO486T, PRO526P, PRO526T, PRO560T, PRO563T, PRO580P, PRO589P, PRO646P, PRO94T, SER109T, SER110T, SER138P, SER175P, SER247T, SER251P, SER255P, SER255T, SER256P, SER257P, SER260P, SER260T, SER264T, SER283T, SER288T, SER347T, SER354T, SER452P, SER455P, SER495P, SER500P, SER511P, SER529P, SER529T, SER534T, SER537T, SER541T, SER550T, SER574P, SER578P, SER581P, SER594T, SER598T, SER602T, SER612T, SER621P, SER621T, SER629P, SER643P, SER65P, SER72P, SER83T, THR122P, THR139P, THR148P, THR165P, THR168P, THR171P, THR246T, THR258P, THR265T, THR278T, THR286T, THR336P, THR350T, THR356P, THR356T, THR362P, THR425T, THR430T, THR442P, THR44P, THR458P, THR465T, THR467T, THR494P, THR531P, THR531T, THR536P, THR536T, THR601T, THR606T, THR610T, THR618P, THR618T, THR631P, THR81P, TRP159P, TRP48P, TRP566T, TRP645P, TRP92P, TRP92T, TYR215P, TYR294P, TYR360P, TYR360T, TYR562T, TYR71P, VAL107T, VAL119P, VAL140P, VAL156P, VAL238T, VAL249T, VAL253P, VAL282T, VAL284T, VAL348T, VAL353P, VAL353T, VAL411T, VAL466T, VAL469T, VAL485T, VAL498P, VAL520P, VAL521P, VAL527P, VAL540T, VAL545T, VAL552T, VAL577P, VAL586P, VAL604T, VAL617T, VAL74P
• P-U: ALA113U, ALA115U, ALA80U, ARG49P, ASN124U, ASN133P, ASN77U, GLN83U, GLY52P, GLY81U, GLY82U, PRO110U, PRO50P, PRO78U, SER116P, SER54P, THR115P, THR132P, THR53P, VAL111U, VAL55P
• P-W: ARG889W, ASP277P
• Q-R: ALA176R, ALA179R, ALA188R, ALA190R, ALA211R, ALA217R, ALA230R, ALA232R, ALA239R, ALA241R, ALA244R, ALA245R, ALA30Q, ALA31Q, ALA33Q, ALA85R, ALA98R, ARG214R, ARG627R, ARG79R, ASN12Q, ASN182R, ASN18Q, ASN205R, ASN209R, ASN222R, ASN243R, ASN3Q, ASN42Q, ASN75R, ASN9Q, ASP16Q, ASP173R, ASP224R, ASP229R, ASP25Q, ASP35Q, ASP88R, CYS181R, CYS200R, GLN146R, GLN160R, GLN231R, GLN5Q, GLN628R, GLN635R, GLN93R, GLN97R, GLU206R, GLU237R, GLU80R, GLY15Q, GLY177R, GLY17Q, GLY221R, GLY236R, GLY240R, GLY2Q, GLY45R, GLY77R, HIS213R, HIS233R, ILE13Q, ILE142R, ILE149R, ILE174R, ILE212R, ILE34Q, ILE641R, ILE89R, LEU145R, LEU163R, LEU170R, LEU186R, LEU187R, LEU201R, LEU218R, LEU227R, LEU235R, LEU36Q, LEU41Q, LEU624R, LEU86R, LEU95R, LYS100R, LYS184R, LYS191R, LYS219R, LYS226R, LYS37Q, LYS46R, LYS634R, LYS84R, MET153R, MET167R, MET26Q, MET78R, MET91R, PHE207R, PHE20Q, PHE242R, PHE637R, PHE638R, PHE73R, PHE82R, PHE87R, PHE96R, PRO172R, PRO204R, PRO216R, PRO220R, PRO223R, PRO228R, PRO22Q, PRO234R, PRO32Q, PRO94R, SER175R, SER178R, SER180R, SER19Q, SER247R, SER24Q, SER28Q, SER72R, SER7Q, SER83R, THR10Q, THR14Q, THR168R, THR171R, THR202R, THR21Q, THR225R, THR23Q, THR246R, THR27Q, THR29Q, THR44R, THR631R, THR6Q, THR81R, THR99R, TRP183R, TRP92R, TYR11Q, TYR203R, TYR208R, TYR215R, VAL210R, VAL238R, VAL253R, VAL40Q, VAL4Q, VAL74R, VAL8Q
• Q-S: ALA30Q, ALA31Q, ALA33Q, ASN42S, ASP35Q, ASP35S, GLY39S, ILE34Q, LEU36Q, LEU36S, LEU41S, LYS37S, PRO32Q, PRO38S, SER28Q, THR27Q, THR29Q, VAL40Q, VAL40S
• Q-T: ALA123T, ALA262T, ALA267T, ALA62T, ARG147T, ARG609T, ASP25Q, ASP35Q, GLN146T, GLN261T, GLN70T, GLY268T, GLY39Q, GLY611T, ILE142T, ILE263T, ILE63T, LEU259T, LEU36Q, LEU608T, LEU613T, LEU61T, LYS37Q, LYS46T, MET143T, MET266T, MET26Q, PRO38Q, SER24Q, SER256T, SER257T, SER260T, SER264T, SER612T, THR10Q, THR139T, THR23Q, THR265T, THR610T, TRP48T, TYR11Q, VAL40Q
• R-S: ALA239R, ALA241R, ALA262R, ALA30S, ALA31S, ALA33S, ALA607R, ARG609R, ASN243R, ASN42S, ASP35S, ASP88R, GLN261R, GLU237R, GLU80R, GLY236R, GLY240R, GLY254R, GLY39S, GLY605R, GLY611R, GLY614R, ILE263R, ILE34S, LEU235R, LEU252R, LEU259R, LEU36S, LEU41S, LEU608R, LEU613R, LYS37S, LYS615R, LYS84R, MET26S, MET91R, PHE242R, PHE87R, PRO22S, PRO32S, PRO38S, SER251R, SER255R, SER256R, SER257R, SER260R, SER264R, SER28S, SER612R, THR258R, THR27S, THR29S, THR606R, THR610R, THR81R, VAL238R, VAL253R, VAL40S
• R-T: ALA121T, ALA123T, ALA126T, ALA150T, ALA151T, ALA157T, ALA166T, ALA190T, ALA211T, ALA217T, ALA230R, ALA232R, ALA239R, ALA239T, ALA241R, ALA244R, ALA244T, ALA245R, ALA245T, ALA267R, ALA276R, ALA290R, ALA297T, ALA304T, ALA400R, ALA402R, ALA404T, ALA408R, ALA483R, ALA487R, ALA499T, ALA501T, ALA503R, ALA518T, ALA524T, ALA528T, ALA535R, ALA538R, ALA544R, ALA572T, ALA573T, ALA599R, ALA607R, ALA620R, ALA620T, ALA626T, ALA633T, ALA636T, ALA85R, ALA85T, ARG147T, ARG152T, ARG154T, ARG214T, ARG292R, ARG295R, ARG295T, ARG337T, ARG412R, ARG416R, ARG416T, ARG428R, ARG472R, ARG530R, ARG530T, ARG542R, ARG567T, ARG571T, ARG609R, ARG625T, ARG627T, ARG67T, ARG79R, ARG79T, ASN129T, ASN144T, ASN198T, ASN222R, ASN243R, ASN243T, ASN363T, ASN406R, ASN410R, ASN418R, ASN453T, ASN456T, ASN504R, ASN512T, ASN515T, ASN519T, ASN579T, ASN75T, ASN90R, ASP125T, ASP128T, ASP155T, ASP164T, ASP173T, ASP192T, ASP197T, ASP229R, ASP270R, ASP272R, ASP277R, ASP303T, ASP346R, ASP352R, ASP461T, ASP482R, ASP523T, ASP532R, ASP532T, ASP533R, ASP561R, ASP619R, ASP619T, ASP639T, ASP66T, ASP88R, ASP88T, GLN141T, GLN146T, GLN160T, GLN231R, GLN261R, GLN261T, GLN330T, GLN414R, GLN414T, GLN423R, GLN546R, GLN551R, GLN585T, GLN628T, GLN640T, GLN70T, GLN93R, GLN97R, GLU237R, GLU248R, GLU275R, GLU302T, GLU309T, GLU427R, GLU429R, GLU473R, GLU496T, GLU497T, GLU622T, GLU76R, GLU76T, GLU80R, GLU80T, GLY104R, GLY120T, GLY124T, GLY236R, GLY240R, GLY240T, GLY250R, GLY250T, GLY254T, GLY268R, GLY332T, GLY334T, GLY355R, GLY355T, GLY401R, GLY413R, GLY441T, GLY45T, GLY462T, GLY522T, GLY553R, GLY587T, GLY595R, GLY603R, GLY605R, GLY611R, GLY614R, GLY616R, GLY642T, GLY69T, GLY77R, GLY77T, HIS162T, HIS213R, HIS213T, HIS233R, HIS421R, HIS547R, ILE106R, ILE137T, ILE142T, ILE149T, ILE174T, ILE193T, ILE263R, ILE274R, ILE299T, ILE307T, ILE345R, ILE357R, ILE357T, ILE409R, ILE445T, ILE484R, ILE525R, ILE525T, ILE539R, ILE588T, ILE58T, ILE63T, ILE641T, ILE89R, ILE89T, LEU108R, LEU108T, LEU127T, LEU145T, LEU158T, LEU163T, LEU170T, LEU186T, LEU194T, LEU196T, LEU235R, LEU252R, LEU252T, LEU259R, LEU259T, LEU271R, LEU273R, LEU280R, LEU289R, LEU358T, LEU366T, LEU407R, LEU420R, LEU422R, LEU459T, LEU463R, LEU470R, LEU471R, LEU47T, LEU509R, LEU514T, LEU517T, LEU543R, LEU549R, LEU565R, LEU582T, LEU591T, LEU597R, LEU600R, LEU608R, LEU613R, LEU624T, LEU630T, LEU644T, LEU86R, LEU86T, LYS161T, LYS191T, LYS269R, LYS300T, LYS46T, LYS516R, LYS516T, LYS548R, LYS570T, LYS615R, LYS615T, LYS623T, LYS634T, LYS84R, LYS84T, MET143T, MET153T, MET167T, MET169T, MET266R, MET419R, MET460T, MET575T, MET78T, MET91R, MET91T, PHE189T, PHE242R, PHE285R, PHE298T, PHE417R, PHE417T, PHE426R, PHE443T, PHE454T, PHE576T, PHE637T, PHE638T, PHE68T, PHE73T, PHE82T, PHE87R, PHE96R, PRO105R, PRO130T, PRO172T, PRO195T, PRO216R, PRO216T, PRO220R, PRO234R, PRO279R, PRO281R, PRO287R, PRO291R, PRO296T, PRO301T, PRO333T, PRO335T, PRO359T, PRO371T, PRO415R, PRO415T, PRO43T, PRO457T, PRO468R, PRO486R, PRO526R, PRO526T, PRO560R, PRO563R, PRO580T, PRO589T, PRO646T, PRO94R, SER109R, SER110R, SER138T, SER175T, SER247R, SER251T, SER255R, SER255T, SER256T, SER257T, SER260R, SER260T, SER264R, SER283R, SER288R, SER347R, SER354R, SER452T, SER455T, SER495T, SER500T, SER511T, SER529R, SER529T, SER534R, SER537R, SER541R, SER550R, SER574T, SER578T, SER581T, SER594R, SER598R, SER602R, SER612R, SER621R, SER621T, SER629T, SER643T, SER65T, SER72T, SER83R, THR122T, THR139T, THR148T, THR165T, THR168T, THR171T, THR246R, THR258T, THR265R, THR278R, THR286R, THR336T, THR350R, THR356R, THR356T, THR362T, THR425R, THR430R, THR442T, THR44T, THR458T, THR465R, THR467R, THR494T, THR531R, THR531T, THR536R, THR536T, THR601R, THR606R, THR610R, THR618R, THR618T, THR631T, THR81T, TRP159T, TRP48T, TRP566R, TRP645T, TRP92R, TRP92T, TYR215T, TYR294T, TYR360R, TYR360T, TYR562R, TYR71T, VAL107R, VAL119T, VAL140T, VAL156T, VAL238R, VAL249R, VAL253T, VAL282R, VAL284R, VAL348R, VAL353R, VAL353T, VAL411R, VAL466R, VAL469R, VAL485R, VAL498T, VAL520T, VAL521T, VAL527T, VAL540R, VAL545R, VAL552R, VAL577T, VAL586T, VAL604R, VAL617R, VAL74T
• R-W: ARG625R, ARG889W, GLN628R, PRO869W
• S-T: ALA176T, ALA179T, ALA188T, ALA190T, ALA211T, ALA217T, ALA230T, ALA232T, ALA239T, ALA241T, ALA244T, ALA245T, ALA30S, ALA31S, ALA33S, ALA85T, ALA98T, ARG214T, ARG627T, ARG79T, ASN12S, ASN182T, ASN18S, ASN205T, ASN209T, ASN222T, ASN243T, ASN3S, ASN42S, ASN75T, ASN9S, ASP16S, ASP173T, ASP224T, ASP229T, ASP25S, ASP35S, ASP88T, CYS181T, CYS200T, GLN146T, GLN160T, GLN231T, GLN5S, GLN628T, GLN635T, GLN93T, GLN97T, GLU206T, GLU237T, GLU80T, GLY15S, GLY177T, GLY17S, GLY221T, GLY236T, GLY240T, GLY2S, GLY45T, GLY77T, HIS213T, HIS233T, ILE13S, ILE142T, ILE149T, ILE174T, ILE212T, ILE34S, ILE641T, ILE89T, LEU145T, LEU163T, LEU170T, LEU186T, LEU187T, LEU201T, LEU218T, LEU227T, LEU235T, LEU36S, LEU41S, LEU624T, LEU86T, LEU95T, LYS100T, LYS184T, LYS191T, LYS219T, LYS226T, LYS37S, LYS46T, LYS634T, LYS84T, MET153T, MET167T, MET26S, MET78T, MET91T, PHE207T, PHE20S, PHE242T, PHE637T, PHE638T, PHE73T, PHE82T, PHE87T, PRO172T, PRO204T, PRO216T, PRO220T, PRO223T, PRO228T, PRO22S, PRO234T, PRO32S, PRO94T, SER175T, SER178T, SER180T, SER19S, SER247T, SER24S, SER28S, SER72T, SER7S, SER83T, THR10S, THR14S, THR168T, THR171T, THR202T, THR21S, THR225T, THR23S, THR246T, THR27S, THR29S, THR44T, THR631T, THR6S, THR81T, THR99T, TRP183T, TRP92T, TYR11S, TYR203T, TYR208T, TYR215T, VAL210T, VAL238T, VAL253T, VAL40S, VAL4S, VAL74T, VAL8S
• T-W: ALA407W, ARG147T, ARG377W, ARG405W, ARG775W, ASP224T, ASP722W, ASP776W, GLY102T, LYS100T
• U-W: ARG213W, ARG353W, ARG4U, ASP121U, ASP167W, ASP201U, ASP355W
• U-X: ARG191U, ARG35U, ARG407X, ARG437X, ARG93U, ARG947X, ARG959X, ASP372X, ASP789X, ASP933X, ASP94U, CYS32U, GLN187U, GLN245U, GLN418X, GLU235U, GLU28U, GLU449X, GLU948X, HIS184U, HIS410X, HIS43U, HIS949X, HIS956X, LEU880X, LYS238U, MET175U, MET404X, PRO952X, SER408X, THR203U, TYR1195X
• V-X: ARG1023X, ARG57V, ASN1025X, ASP1040X, HIS43V, PRO1022X, SER42V, THR48V
• V-Y: ALA176V, ALA45V, ARG191V, ARG407Y, ARG437Y, ARG959Y, ASN375Y, ASP252V, ASP412Y, GLN195V, GLN245V, GLN415Y, HIS184V, HIS956Y, ILE434Y, LEU436Y, SER47V
• W-X: ARG129W, ARG170W, ARG647X, ARG773X, ASN681X, ASP161W, ASP246W, ASP694X, GLU76W, HIS645X, HIS72W
• X-Y: ARG1016X, ARG1211Y, ARG125Y, ARG686Y, ARG710Y, ARG726Y, ARG737Y, ARG793X, ARG801X, ARG889X, ARG930X, ASN113Y, ASN713Y, ASP1050X, ASP1061X, ASP1095X, ASP578X, ASP723Y, ASP795X, ASP799X, ASP876X, ASP928X, GLN738Y, GLN890X, GLU1101X, GLU900X, HIS580X, HIS617X, HIS804X, HIS835Y, LYS107Y, LYS584X, LYS740Y, PRO103Y, SER1093X, THR1214Y, THR688Y, THR734Y, THR803X, THR829Y, TYR926X