3IWP

crystal structure of human copper homeostasis protein cutc

• Total interactions analyzed: 66
• Total true interactions: 20
• Strongest Interaction:
  • Chains: B-D
  • Int. Res.: 43
  • Norm. En. per Res.: -5.4841
• Hub Node: A(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-62.5502	-42.4203	-601.359	-706.3296	228	21	8	25101	3	60	56
A-C	-23.2105	-94.667	-108.645	-226.5225	52	6	1	3852	4	12	16
A-D	0.0	0.0	-10.7931	-10.7931	26	2	0	520	0	2	2
B-C	0.0	0.0	-5.066	-5.066	22	5	0	586	0	2	1
B-D	-38.8632	-109.8934	-87.0618	-235.8184	43	8	1	3425	4	12	16
C-D	-62.4239	-28.5702	-592.688	-683.6821	228	33	9	25033	2	63	55
C-F	0.0	0.0	-0.0032	-0.0032	3	0	0	5	0	0	0
D-I	0.0	0.0	-0.0131	-0.0131	3	0	0	11	0	0	0
E-F	-48.8048	-25.8798	-534.99	-609.6747	220	26	8	22757	0	60	53
E-G	-34.2846	-81.7367	-88.672	-204.6933	46	5	1	3735	2	12	16
E-H	0.0	0.0	-7.4604	-7.4604	14	0	0	376	0	2	1
F-G	0.0	0.0	-4.6111	-4.6111	14	2	0	349	0	2	1
F-H	-20.491	-61.087	-72.6265	-154.2045	41	2	1	3060	2	12	16
G-H	-43.6711	-26.8752	-485.513	-556.0594	191	20	8	19773	4	53	48
I-J	-41.4135	-41.8485	-483.006	-566.2681	197	20	8	19767	5	66	54
I-K	-13.9589	-89.4418	-74.908	-178.3087	45	6	1	3174	2	12	15
I-L	0.0	0.0	-9.9348	-9.9348	17	3	0	492	0	1	2
J-K	0.0	0.0	-13.9754	-13.9754	17	2	0	495	0	0	1
J-L	-20.2947	-99.1086	-74.8838	-194.2871	45	7	1	3130	6	12	16
K-L	-81.3574	-48.0735	-574.088	-703.5189	209	30	8	23634	2	57	45

Interface residues

• A-B: ALA101A, ALA101B, ALA106A, ALA106B, ALA118A, ALA147A, ALA147B, ALA241A, ALA241B, ALA244A, ALA38A, ALA38B, ARG104A, ARG104B, ARG146A, ARG146B, ARG226B, ARG229A, ARG229B, ARG236A, ARG236B, ARG43A, ARG43B, ARG83A, ARG83B, ARG85A, ARG85B, ARG94A, ARG94B, ASN237A, ASN237B, ASN40A, ASN40B, ASP102A, ASP102B, ASP122A, ASP122B, ASP149A, ASP149B, ASP153A, ASP153B, ASP175A, ASP175B, ASP230A, ASP230B, ASP33A, ASP33B, ASP88A, ASP88B, ASP93A, ASP93B, CYS174A, CYS174B, CYS248A, CYS248B, GLN68A, GLN68B, GLN72A, GLN72B, GLU121A, GLU121B, GLU180A, GLU180B, GLU250A, GLU250B, GLU36A, GLU36B, GLU57A, GLU57B, GLU95A, GLU95B, GLU97A, GLU97B, GLY123A, GLY123B, GLY173A, GLY173B, GLY202A, GLY202B, GLY203A, GLY232A, GLY232B, GLY243A, GLY243B, GLY54A, GLY54B, GLY58A, GLY58B, GLY59A, GLY59B, GLY65A, GLY65B, GLY86A, GLY86B, GLY87A, GLY87B, HIS124A, HIS124B, HIS145A, HIS145B, HIS152A, HIS152B, ILE103A, ILE103B, ILE125A, ILE125B, ILE82A, ILE82B, ILE96A, ILE96B, LEU105A, LEU105B, LEU108A, LEU108B, LEU119A, LEU119B, LEU170A, LEU184A, LEU184B, LEU246A, LEU253A, LEU253B, LEU51A, LEU51B, LEU55A, LEU55B, LEU67A, LEU67B, LEU90A, LEU90B, LYS100A, LYS100B, LYS234A, LYS234B, LYS254A, LYS254B, LYS71A, MET150A, MET150B, MET233A, MET233B, MET242A, MET242B, MET64A, MET64B, MET81A, MET81B, MET99A, MET99B, PHE148A, PHE148B, PHE235A, PHE235B, PHE89A, PHE89B, PRO154A, PRO154B, PRO62A, PRO62B, PRO84A, PRO84B, SER172A, SER172B, SER176A, SER176B, SER177A, SER177B, SER224A, SER231A, SER231B, SER238A, SER238B, SER239A, SER239B, SER245A, SER247A, SER249A, SER249B, SER252A, SER252B, SER34A, SER34B, SER37A, SER37B, SER53A, SER53B, SER56A, SER56B, SER63A, SER63B, SER73A, SER73B, SER92A, SER92B, THR120A, THR120B, THR171A, THR171B, THR60A, THR60B, THR61A, THR61B, TYR109A, TYR109B, TYR251A, TYR251B, TYR91A, VAL151A, VAL151B, VAL240A, VAL240B, VAL255A, VAL255B, VAL258A, VAL35A, VAL35B, VAL39A, VAL39B, VAL66A, VAL66B, VAL69A, VAL69B, VAL70A, VAL70B, VAL74B, VAL80B, VAL98A, VAL98B
• A-C: ALA178A, ALA178C, ALA241C, ALA244A, ALA244C, ARG207A, ARG207C, ARG211A, ARG211C, ASN208A, ASN208C, ASP175A, ASP175C, CYS174A, CYS174C, CYS248A, CYS248C, GLU180A, GLU180C, GLY173A, GLY181A, GLY181C, GLY202A, GLY202C, GLY203A, GLY203C, ILE185A, ILE185C, ILE204A, ILE204C, ILE212A, ILE212C, LEU179A, LEU179C, LEU182A, LEU182C, LEU184A, LEU184C, LEU209A, LEU246A, PRO183A, PRO183C, SER172A, SER176A, SER176C, SER177A, SER177C, SER245A, SER245C, SER247A, THR205A, THR205C
• A-D: ARG207A, ARG207D, ASN237A, ASN237D, CYS248A, CYS248D, GLY203D, LEU246A, LYS254A, LYS260A, LYS260D, SER176D, SER177D, SER227D, SER238A, SER238D, SER239A, SER239D, SER247A, SER249A, THR205A, THR205D, THR228A, THR228D, VAL240A, VAL240D
• B-C: ARG207B, ARG207C, ARG236B, ASN237B, ASN237C, CYS248B, CYS248C, LYS260B, LYS260C, PHE235B, SER238B, SER238C, SER239B, SER239C, SER249B, SER249C, THR205B, THR205C, THR228B, THR228C, VAL240B, VAL240C
• B-D: ALA178B, ALA178D, ARG207B, ARG207D, ARG211B, ARG211D, ASN208B, ASN208D, ASP175B, ASP175D, CYS174B, CYS174D, GLU180B, GLU180D, GLY173B, GLY173D, GLY181B, GLY181D, GLY202B, GLY202D, GLY203B, GLY203D, ILE185D, ILE204B, ILE204D, ILE212B, ILE212D, LEU179B, LEU179D, LEU182B, LEU182D, LEU184B, LEU184D, LEU209B, LEU209D, PRO183B, PRO183D, SER176B, SER176D, SER177B, SER177D, THR205B, THR205D
• C-D: ALA101C, ALA101D, ALA106C, ALA106D, ALA118C, ALA118D, ALA147C, ALA147D, ALA241C, ALA241D, ALA244C, ALA38C, ALA38D, ARG104C, ARG104D, ARG146C, ARG146D, ARG226C, ARG226D, ARG229C, ARG229D, ARG236C, ARG236D, ARG43C, ARG43D, ARG83C, ARG83D, ARG85C, ARG85D, ARG94C, ARG94D, ASN237C, ASN237D, ASN40C, ASN40D, ASP102C, ASP102D, ASP122C, ASP122D, ASP149C, ASP149D, ASP153C, ASP153D, ASP175C, ASP175D, ASP230C, ASP230D, ASP33C, ASP33D, ASP88C, ASP88D, ASP93C, ASP93D, CYS174C, CYS174D, CYS248D, CYS52C, GLN68C, GLN68D, GLN72C, GLN72D, GLU121C, GLU121D, GLU180C, GLU180D, GLU250C, GLU250D, GLU36C, GLU36D, GLU57C, GLU57D, GLU95C, GLU95D, GLU97C, GLU97D, GLY117D, GLY123C, GLY123D, GLY173C, GLY173D, GLY202C, GLY202D, GLY232C, GLY232D, GLY243C, GLY243D, GLY54C, GLY54D, GLY58C, GLY58D, GLY59C, GLY59D, GLY65C, GLY65D, GLY86C, GLY86D, GLY87C, GLY87D, HIS124C, HIS124D, HIS145C, HIS145D, HIS152C, HIS152D, ILE103C, ILE103D, ILE125C, ILE125D, ILE82C, ILE82D, ILE96C, ILE96D, LEU105C, LEU105D, LEU108C, LEU108D, LEU119C, LEU119D, LEU170C, LEU170D, LEU184D, LEU253C, LEU253D, LEU51C, LEU51D, LEU55C, LEU55D, LEU67C, LEU67D, LEU90C, LEU90D, LYS100C, LYS100D, LYS234C, LYS234D, LYS254C, LYS254D, LYS71D, MET150C, MET150D, MET233C, MET233D, MET242C, MET242D, MET64C, MET64D, MET81C, MET81D, MET99C, MET99D, PHE148C, PHE148D, PHE235C, PHE235D, PHE89C, PHE89D, PRO154C, PRO154D, PRO62C, PRO62D, PRO84C, PRO84D, SER172C, SER172D, SER176C, SER176D, SER177C, SER177D, SER231C, SER231D, SER238C, SER238D, SER239C, SER239D, SER245C, SER247D, SER249C, SER249D, SER252C, SER252D, SER34C, SER34D, SER37C, SER37D, SER53C, SER53D, SER56C, SER56D, SER63C, SER63D, SER73C, SER73D, SER92C, SER92D, THR120C, THR120D, THR171C, THR60C, THR60D, THR61C, THR61D, TYR109C, TYR109D, TYR251C, TYR251D, TYR91C, TYR91D, VAL151C, VAL151D, VAL240C, VAL240D, VAL255C, VAL255D, VAL35C, VAL35D, VAL39C, VAL39D, VAL66C, VAL66D, VAL69C, VAL69D, VAL70C, VAL70D, VAL74D, VAL80C, VAL80D, VAL98C, VAL98D
• C-F: ARG104C, GLN75F, ILE136C
• D-I: ARG104D, GLN75I, ILE136D
• E-F: ALA101E, ALA101F, ALA106E, ALA106F, ALA118E, ALA118F, ALA147E, ALA147F, ALA241E, ALA241F, ALA38E, ALA38F, ARG104E, ARG104F, ARG146E, ARG146F, ARG226E, ARG229E, ARG236E, ARG236F, ARG43E, ARG43F, ARG83E, ARG83F, ARG85E, ARG85F, ARG94E, ARG94F, ASN237E, ASN237F, ASN40E, ASN40F, ASP102E, ASP102F, ASP122E, ASP122F, ASP126E, ASP126F, ASP149E, ASP149F, ASP153E, ASP153F, ASP175E, ASP175F, ASP230E, ASP230F, ASP33E, ASP33F, ASP88E, ASP88F, ASP93E, ASP93F, CYS174E, CYS174F, CYS248E, CYS52E, GLN68E, GLN68F, GLN72E, GLN72F, GLU121E, GLU121F, GLU180E, GLU180F, GLU250E, GLU250F, GLU36E, GLU36F, GLU57E, GLU57F, GLU95E, GLU95F, GLU97E, GLU97F, GLY123E, GLY123F, GLY173E, GLY173F, GLY181F, GLY201F, GLY202E, GLY202F, GLY203E, GLY232E, GLY232F, GLY243F, GLY54E, GLY54F, GLY58E, GLY58F, GLY59E, GLY65E, GLY65F, GLY86E, GLY86F, GLY87E, GLY87F, HIS124E, HIS124F, HIS145E, HIS152E, HIS152F, HIS222E, ILE103E, ILE103F, ILE82E, ILE82F, ILE96E, ILE96F, LEU105E, LEU105F, LEU108E, LEU108F, LEU119E, LEU119F, LEU170E, LEU184E, LEU253E, LEU253F, LEU51E, LEU51F, LEU55E, LEU55F, LEU67E, LEU67F, LEU90E, LEU90F, LYS100E, LYS100F, LYS234E, LYS234F, LYS254E, LYS254F, LYS71F, MET150E, MET150F, MET233E, MET233F, MET242F, MET64E, MET64F, MET81E, MET81F, MET99E, MET99F, PHE148E, PHE148F, PHE235E, PHE235F, PHE89E, PHE89F, PRO154E, PRO154F, PRO62E, PRO62F, PRO84E, PRO84F, SER172E, SER172F, SER176E, SER176F, SER177E, SER177F, SER224E, SER231E, SER231F, SER238E, SER238F, SER239E, SER239F, SER249E, SER252E, SER252F, SER34E, SER34F, SER37E, SER37F, SER53E, SER53F, SER56E, SER56F, SER63E, SER63F, SER73E, SER73F, SER92E, SER92F, THR120E, THR120F, THR171E, THR171F, THR60E, THR60F, THR61E, THR61F, TYR109E, TYR109F, TYR251E, TYR251F, TYR91E, TYR91F, VAL151E, VAL151F, VAL240E, VAL240F, VAL255E, VAL255F, VAL35E, VAL35F, VAL39E, VAL39F, VAL66E, VAL66F, VAL69E, VAL69F, VAL70E, VAL70F, VAL80F, VAL98E, VAL98F
• E-G: ALA178E, ALA178G, ARG187G, ARG207E, ARG207G, ARG211E, ARG211G, ASN208E, ASN208G, ASP175E, ASP175G, CYS174E, CYS174G, GLN210E, GLU180E, GLU180G, GLY173E, GLY173G, GLY181E, GLY181G, GLY202E, GLY202G, GLY203E, GLY203G, GLY215E, ILE185E, ILE185G, ILE204E, ILE204G, ILE212E, ILE212G, LEU179E, LEU179G, LEU182E, LEU182G, LEU184E, LEU184G, LYS186G, PRO183E, PRO183G, SER176E, SER176G, SER177E, SER177G, THR205E, THR205G
• E-H: ARG207E, ARG207H, ASN237E, ASN237H, LYS260H, SER227H, SER238E, SER238H, SER239E, SER239H, THR205E, THR205H, THR228H, VAL240E
• F-G: ARG207G, ARG226F, ASN237F, LYS260F, LYS260G, SER227G, SER238F, SER238G, SER239F, THR205F, THR205G, THR228F, THR228G, VAL240F
• F-H: ALA178F, ALA178H, ARG207F, ARG207H, ARG211F, ARG211H, ASN208F, ASN208H, ASP175F, ASP175H, ASP206F, CYS174F, CYS174H, GLU180F, GLU180H, GLY173F, GLY173H, GLY181F, GLY181H, GLY202F, GLY203F, GLY203H, ILE185H, ILE204F, ILE204H, ILE212F, ILE212H, LEU179F, LEU179H, LEU182F, LEU182H, LEU184F, LEU184H, PRO183F, PRO183H, SER176F, SER176H, SER177F, SER177H, THR205F, THR205H
• G-H: ALA101G, ALA101H, ALA106G, ALA106H, ALA118G, ALA118H, ALA147H, ALA38G, ALA38H, ARG104G, ARG104H, ARG146G, ARG146H, ARG226G, ARG226H, ARG236G, ARG236H, ARG43G, ARG43H, ARG83G, ARG83H, ARG85G, ARG85H, ARG94G, ARG94H, ASN237G, ASN237H, ASN40G, ASN40H, ASP102G, ASP102H, ASP122G, ASP122H, ASP149G, ASP149H, ASP153G, ASP153H, ASP175G, ASP175H, ASP230G, ASP230H, ASP33G, ASP33H, ASP88G, ASP88H, ASP93G, ASP93H, CYS174G, CYS174H, GLN68G, GLN68H, GLN72G, GLN72H, GLU121G, GLU121H, GLU180G, GLU36G, GLU36H, GLU57G, GLU57H, GLU95G, GLU95H, GLU97G, GLU97H, GLY123G, GLY123H, GLY173G, GLY173H, GLY202G, GLY232G, GLY232H, GLY54G, GLY54H, GLY58G, GLY65G, GLY65H, GLY86G, GLY86H, GLY87G, GLY87H, HIS124G, HIS124H, HIS152G, HIS152H, ILE103G, ILE103H, ILE125G, ILE125H, ILE82G, ILE82H, ILE96G, ILE96H, LEU105G, LEU105H, LEU108G, LEU108H, LEU119G, LEU119H, LEU253G, LEU253H, LEU55G, LEU55H, LEU67G, LEU67H, LEU90G, LEU90H, LYS100G, LYS100H, LYS234G, LYS234H, LYS254G, LYS254H, MET150G, MET150H, MET233G, MET233H, MET64G, MET64H, MET81G, MET81H, MET99G, MET99H, PHE148G, PHE148H, PHE235G, PHE235H, PHE89G, PHE89H, PRO154G, PRO154H, PRO62G, PRO62H, PRO84G, PRO84H, SER172G, SER172H, SER176G, SER176H, SER177G, SER177H, SER231G, SER231H, SER238G, SER238H, SER239G, SER239H, SER252G, SER252H, SER34G, SER34H, SER37G, SER37H, SER53G, SER53H, SER56G, SER56H, SER63G, SER63H, SER73G, SER73H, SER92G, SER92H, THR120G, THR120H, THR60G, THR60H, THR61G, THR61H, TYR109G, TYR109H, TYR251G, TYR91G, TYR91H, VAL151G, VAL151H, VAL240H, VAL255G, VAL255H, VAL35G, VAL35H, VAL39G, VAL39H, VAL66G, VAL66H, VAL69G, VAL69H, VAL70G, VAL70H, VAL74G, VAL98G, VAL98H
• I-J: ALA101I, ALA101J, ALA106I, ALA106J, ALA118I, ALA118J, ALA147I, ALA147J, ALA38I, ALA41I, ARG104I, ARG104J, ARG146I, ARG146J, ARG226I, ARG236I, ARG236J, ARG43I, ARG43J, ARG83I, ARG83J, ARG85I, ARG85J, ARG94I, ARG94J, ASN237I, ASN237J, ASN40I, ASN40J, ASP102I, ASP102J, ASP122I, ASP122J, ASP126J, ASP149I, ASP149J, ASP153I, ASP153J, ASP175I, ASP175J, ASP230I, ASP230J, ASP33I, ASP33J, ASP88I, ASP88J, ASP93I, ASP93J, CYS174I, CYS174J, GLN68I, GLN68J, GLN72I, GLN72J, GLU121I, GLU121J, GLU180I, GLU180J, GLU250I, GLU250J, GLU36I, GLU36J, GLU57I, GLU57J, GLU95I, GLU95J, GLU97I, GLU97J, GLY123I, GLY123J, GLY173I, GLY173J, GLY232I, GLY232J, GLY54I, GLY54J, GLY58J, GLY65I, GLY65J, GLY86I, GLY86J, GLY87I, GLY87J, HIS124I, HIS124J, HIS152I, HIS152J, ILE103I, ILE103J, ILE82I, ILE82J, ILE96I, ILE96J, LEU105I, LEU105J, LEU108I, LEU108J, LEU119I, LEU119J, LEU253I, LEU253J, LEU51I, LEU51J, LEU55I, LEU55J, LEU67I, LEU67J, LEU90I, LEU90J, LYS100I, LYS100J, LYS234I, LYS234J, LYS254I, LYS254J, MET150I, MET150J, MET233I, MET233J, MET64I, MET64J, MET81I, MET81J, MET99I, MET99J, PHE148I, PHE148J, PHE235I, PHE235J, PHE89I, PHE89J, PRO154J, PRO62I, PRO62J, PRO84I, PRO84J, SER172I, SER172J, SER176I, SER176J, SER177I, SER177J, SER231I, SER231J, SER238I, SER238J, SER239I, SER239J, SER249I, SER249J, SER252I, SER252J, SER34I, SER34J, SER37I, SER37J, SER53I, SER53J, SER56I, SER56J, SER63I, SER63J, SER73I, SER73J, SER92I, SER92J, THR120I, THR120J, THR60I, THR60J, THR61I, THR61J, TYR109I, TYR109J, TYR251I, TYR251J, TYR91I, TYR91J, VAL151I, VAL151J, VAL255I, VAL255J, VAL35I, VAL35J, VAL39I, VAL39J, VAL66I, VAL66J, VAL69I, VAL69J, VAL70I, VAL70J, VAL74I, VAL80I, VAL80J, VAL98I, VAL98J
• I-K: ALA178I, ALA178K, ARG187I, ARG207I, ARG207K, ARG211I, ARG211K, ASN208I, ASN208K, ASP175I, ASP175K, CYS174I, CYS174K, GLU180I, GLU180K, GLY173K, GLY181I, GLY181K, GLY202I, GLY202K, GLY203I, GLY203K, GLY215I, ILE185I, ILE204I, ILE204K, ILE212I, ILE212K, LEU179I, LEU179K, LEU182I, LEU182K, LEU184I, LEU184K, LEU209I, LEU209K, LYS186K, PRO183I, PRO183K, SER176I, SER176K, SER177I, SER177K, THR205I, THR205K
• I-L: ARG207I, ARG207L, ARG236I, ASN237I, ASN237L, LYS260I, LYS260L, PHE235I, SER227L, SER238I, SER238L, SER239I, SER239L, THR205I, THR205L, THR228L, VAL240L
• J-K: ARG207J, ARG207K, ASN208J, ASN237J, ASN237K, ASP206J, LYS260J, SER227J, SER238J, SER238K, SER239J, SER239K, SER249J, THR205J, THR205K, THR228K, VAL240K
• J-L: ALA178J, ALA178L, ARG207J, ARG207L, ARG211J, ARG211L, ASN208J, ASN208L, ASP149J, ASP175J, ASP175L, ASP206J, CYS174J, CYS174L, GLN210L, GLU180J, GLU180L, GLY173J, GLY173L, GLY181J, GLY181L, GLY202L, GLY203J, GLY203L, ILE204J, ILE204L, ILE212J, ILE212L, LEU179J, LEU179L, LEU182J, LEU182L, LEU184J, LEU184L, LEU209J, LYS186J, LYS186L, PRO183J, PRO183L, SER176J, SER176L, SER177J, SER177L, THR205J, THR205L
• K-L: ALA101K, ALA101L, ALA106K, ALA106L, ALA118L, ALA147K, ALA147L, ALA241K, ALA241L, ALA38K, ALA38L, ARG104K, ARG104L, ARG146K, ARG146L, ARG226K, ARG229K, ARG236K, ARG236L, ARG43K, ARG43L, ARG83K, ARG83L, ARG85K, ARG85L, ARG94K, ARG94L, ASN237K, ASN237L, ASN40K, ASN40L, ASP102K, ASP102L, ASP122K, ASP122L, ASP149K, ASP149L, ASP153K, ASP153L, ASP175K, ASP175L, ASP230K, ASP230L, ASP33K, ASP33L, ASP88K, ASP88L, ASP93K, ASP93L, CYS174K, CYS174L, CYS31K, GLN68K, GLN68L, GLN72K, GLN72L, GLU121K, GLU121L, GLU180K, GLU180L, GLU36K, GLU36L, GLU42L, GLU57K, GLU57L, GLU95K, GLU95L, GLU97K, GLU97L, GLY123K, GLY123L, GLY173K, GLY173L, GLY181L, GLY202K, GLY202L, GLY232K, GLY232L, GLY54K, GLY54L, GLY58K, GLY58L, GLY65K, GLY65L, GLY86K, GLY86L, GLY87K, GLY87L, HIS124K, HIS124L, HIS152K, HIS152L, ILE103K, ILE103L, ILE125K, ILE82K, ILE82L, ILE96K, ILE96L, LEU105K, LEU105L, LEU108K, LEU108L, LEU119K, LEU119L, LEU184K, LEU184L, LEU253K, LEU253L, LEU55K, LEU67K, LEU67L, LEU90K, LEU90L, LYS100K, LYS100L, LYS234K, LYS234L, LYS254K, LYS254L, MET150K, MET150L, MET233K, MET233L, MET64K, MET64L, MET81K, MET81L, MET99K, MET99L, PHE148K, PHE148L, PHE235K, PHE235L, PHE89K, PHE89L, PRO154K, PRO154L, PRO62K, PRO62L, PRO84K, PRO84L, SER172K, SER172L, SER176K, SER176L, SER177K, SER177L, SER227K, SER231K, SER231L, SER238K, SER238L, SER239K, SER239L, SER252K, SER252L, SER34K, SER34L, SER37K, SER37L, SER53K, SER53L, SER56K, SER56L, SER63K, SER63L, SER73K, SER73L, SER92K, SER92L, THR120K, THR120L, THR171K, THR171L, THR256K, THR60K, THR60L, THR61K, THR61L, TYR109K, TYR109L, TYR251K, TYR251L, TYR91K, TYR91L, VAL151K, VAL151L, VAL240K, VAL240L, VAL255K, VAL255L, VAL32K, VAL35K, VAL35L, VAL39K, VAL39L, VAL66K, VAL66L, VAL69K, VAL69L, VAL70K, VAL70L, VAL74K, VAL74L, VAL80K, VAL80L, VAL98K, VAL98L